Han-Ming Shen

Han-Ming Shen, Sora Lee, Khong Trong Quan, 2020, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

JNK signaling pathway is a key modulator in cell death mediated by reactive oxygen and nitrogen species.

Zheng‐gang Liu, Han-Ming Shen, Zheng-Gang Liu, 2006, Free radical biology & medicine.

Full-coverage regulations of autophagy by ROS: from induction to maturation

Guo-Dong Lu, Han-Ming Shen, Jing Zhou, 2021, Autophagy.

Suppressed NFk B and sustained JNK activation contribute to the sensitization effect of parthenolide to TNF-a-induced apoptosis in human cancer cells

Xianglin Shi, Siyuan Zhang, C. Ong, 2004 .

Critical roles of intracellular thiols and calcium in parthenolide-induced apoptosis in human colorectal cancer cells.

Siyuan Zhang, C. Ong, Han-Ming Shen, 2004, Cancer letters.

Critical role of Bid and Bax in indirubin-3'-monoxime-induced apoptosis in human cancer cells.

Han-Ming Shen, Jie Shi, 2008, Biochemical pharmacology.

Isorhynchophylline, a natural alkaloid, promotes the degradation of alpha-synuclein in neuronal cells via inducing autophagy

Han-Ming Shen, Min Li, Jia-Hong Lu, 2012, Autophagy.

Biomarkers for male reproductive health hazards: are they available?

C. Ong, Han-Ming Shen, S. Chia, 2002, Toxicology letters.

Quercetin induces p53‐independent cancer cell death through lysosome activation by the transcription factor EB and Reactive Oxygen Species‐dependent ferroptosis

Guo-Dong Lu, Han-Ming Shen, Guang Lu, 2021 .

Emodin inhibits tumor cell adhesion through disruption of the membrane lipid Raft-associated integrin signaling pathway.

C. Ong, M. Wenk, G. Shui, 2006, Cancer research.

Calpain activation after mitochondrial permeability transition in microcystin-induced cell death in rat hepatocytes.

C. Ong, Han-Ming Shen, W. Ding, 2002, Biochemical and biophysical research communications.

CRITICAL ROLE OF REACTIVE OXYGEN SPECIES FORMATION IN MICROCYSTIN-INDUCED CYTOSKELETON DISRUPTION IN PRIMARY CULTURED HEPATOCYTES

C. Ong, Han-Ming Shen, W. Ding, 2001, Journal of toxicology and environmental health. Part A.

Critical Role of Reactive Oxygen Species and Mitochondrial Permeability Transition in Microcystin‐Induced Rapid Apoptosis in Rat Hepatocytes

C. Ong, Han-Ming Shen, W. Ding, 2000, Hepatology.

The associations among semen quality, oxidative DNA damage in human spermatozoa and concentrations of cadmium, lead and selenium in seminal plasma.

C. Ong, Han-Ming Shen, De-xiang Xu, 2003, Mutation research.

Hydroxychloroquine/Chloroquine as Therapeutics for COVID-19: Truth under the Mystery

Guo-Dong Lu, Han-Ming Shen, Jing Zhou, 2021, International journal of biological sciences.

Oxidative DNA damage in peripheral leukocytes and its association with expression and polymorphisms of hOGG1: a study of adolescents in a high risk region for hepatocellular carcinoma in China.

Zhi-ming Liu, B. Halliwell, C. Ong, 2003, World journal of gastroenterology.

Artemisinin as an anticancer drug: Recent advances in target profiling and mechanisms of action

Karunakaran A Kalesh, W. Wong, Jigang Wang, 2017, Medicinal research reviews.

Mechanism-Guided Design and Synthesis of a Mitochondria-Targeting Artemisinin Analogue with Enhanced Anticancer Activity.

B. Liu, Jigang Wang, Jianbin Zhang, 2016, Angewandte Chemie.

Andrographolide sensitizes cancer cells to TRAIL-induced apoptosis via p53-mediated death receptor 4 up-regulation

Guo-Dong Lu, C. Ong, Han-Ming Shen, 2008, Molecular Cancer Therapeutics.

Development of a novel method for quantification of autophagic protein degradation by AHA labeling

Jigang Wang, Jianbin Zhang, Q. Lin, 2014, Autophagy.

A Destiny for Degradation: Interplay between Cullin-RING E3 Ligases and Autophagy.

Han-Ming Shen, Liming Wang, Guang Lu, 2021, Trends in cell biology.

Suppression of autophagy during mitosis via CUL4-RING ubiquitin ligases-mediated WIPI2 polyubiquitination and proteasomal degradation

Tianru Wang, D. Xia, Han-Ming Shen, 2019, Autophagy.

CCAAT/enhancer binding protein α predicts poorer prognosis and prevents energy starvation–induced cell death in hepatocellular carcinoma

M. Salto‐Tellez, Guo-Dong Lu, B. Yan, 2015, Hepatology.

Essential role for autophagy protein VMP1 in maintaining neuronal homeostasis and preventing axonal degeneration

H. Cai, Han-Ming Shen, W. Le, 2021, Cell death & disease.

Importance of ROS-mediated autophagy in determining apoptotic cell death induced by physapubescin B

Jian Xu, D. Xia, Han-Ming Shen, 2017, Redox biology.

Nonradioactive quantification of autophagic protein degradation with L-azidohomoalanine labeling

Jigang Wang, Jianbin Zhang, Q. Lin, 2017, Nature Protocols.

To die or to live: the dual role of poly(ADP-ribose) polymerase-1 in autophagy and necrosis under oxidative stress and DNA damage

Qing Huang, Han-Ming Shen, 2009, Autophagy.

A role of autophagy in PTP4A3-driven cancer progression

J. Thiery, Shu-Dong Zhang, Q. Zeng, 2014, Autophagy.

Highly Efficient Threonine-Derived Organocatalysts for Direct Asymmetric Aldol Reactions in Water

Han-Ming Shen, Yixin Lu, Zhaoqin Jiang, 2007 .

Chrysin promotes tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) induced apoptosis in human cancer cell lines.

C. Ong, Han-Ming Shen, Xin Li, 2011, Toxicology in vitro : an international journal published in association with BIBRA.

Chrysin sensitizes tumor necrosis factor-alpha-induced apoptosis in human tumor cells via suppression of nuclear factor-kappaB.

C. Ong, Qing Huang, Han-Ming Shen, 2010, Cancer letters.

Critical role of CAV1/caveolin-1 in cell stress responses in human breast cancer cells via modulation of lysosomal function and autophagy

R. Parton, You-Sun Kim, Han-Ming Shen, 2015, Autophagy.

O‐GlcNAcylation promotes fatty acid synthase activity under nutritional stress as a pro‐survival mechanism in cancer cells

Jigang Wang, T. Lim, Q. Lin, 2022, Proteomics.

Cubic membrane formation supports cell survival of amoeba Chaos under starvation-induced stress

Han-Ming Shen, Yuru Deng, Z. Almsherqi, 2018, Protoplasma.

Targeted metabolomics reveals differential biological effects of nanoplastics and nanoZnO in human lung cells

B. Bay, C. Ong, Han-Ming Shen, 2019, Nanotoxicology.

At the end of the autophagic road: an emerging understanding of lysosomal functions in autophagy.

N. Mizushima, Han-Ming Shen, 2014, Trends in biochemical sciences.

Importance of TFEB acetylation in control of its transcriptional activity and lysosomal function in response to histone deacetylase inhibitors

S. Sze, Tianru Wang, Jung-Eun Park, 2018, Autophagy.

Activation of lysosomal function in the course of autophagy via mTORC1 suppression and autophagosome-lysosome fusion

C. Bauvy, P. Codogno, Jianbin Zhang, 2013, Cell Research.

(−)-Epigallocatechin-3-Gallate Induces Non-Apoptotic Cell Death in Human Cancer Cells via ROS-Mediated Lysosomal Membrane Permeabilization

Fan Zhou, Han-Ming Shen, Naidi Yang, 2012, PloS one.

Identification and characterization of major flavonoids and caffeoylquinic acids in three Compositae plants by LC/DAD-APCI/MS.

C. Ong, Han-Ming Shen, J. Lai, 2007, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

The ALS-FTD-linked gene product, C9orf72, regulates neuronal morphogenesis via autophagy

Huilin Zhou, J. Guan, Song Chen, 2019, Autophagy.

Suppressed NF-kappaB and sustained JNK activation contribute to the sensitization effect of parthenolide to TNF-alpha-induced apoptosis in human cancer cells.

Xianglin Shi, Siyuan Zhang, C. Ong, 2004, Carcinogenesis.

Luteolin, a flavonoid with potential for cancer prevention and therapy.

Yong Lin, Han-Ming Shen, Han-Ming Shen, 2008, Current cancer drug targets.

Protein kinase C inhibition and x-linked inhibitor of apoptosis protein degradation contribute to the sensitization effect of luteolin on tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in cancer cells.

C. Ong, Han-Ming Shen, R. Shi, 2005, Cancer research.

Luteolin sensitizes tumor necrosis factor-α-induced apoptosis in human tumor cells

C. Ong, Han-Ming Shen, R. Shi, 2004, Oncogene.

IinQ attenuates systemic inflammatory responses via selectively impairing the Myddosome complex formation upon TLR4 ligation.

Han-Ming Shen, Sora Lee, H. Byun, 2016, Biochemical pharmacology.

Luteolin sensitizes tumor necrosis factor-alpha-induced apoptosis in human tumor cells.

C. Ong, Han-Ming Shen, R. Shi, 2004, Oncogene.

The atherogenic effects of serum amyloid A are potentially mediated via inflammation and apoptosis.

C. Heng, Han-Ming Shen, D. S. Ooi, 2014, Journal of atherosclerosis and thrombosis.

Myricetin inhibits NLRP3 inflammasome activation via reduction of ROS‐dependent ubiquitination of ASC and promotion of ROS‐independent NLRP3 ubiquitination

D. Xia, Han-Ming Shen, Yihua Wu, 2019, Toxicology and applied pharmacology.

Use of inducible Atg5 deletion and expression cell lines in study of the pro-survival function of autophagy under starvation.

Han-Ming Shen, Xiangjie Sun, Xinqiang Zhu, 2012, Biochemical and biophysical research communications.

Ticagrelor inhibits the NLRP3 inflammasome to protect against inflammatory disease independent of the P2Y12 signaling pathway

P. Héroux, D. Xia, Han-Ming Shen, 2020, Cellular & Molecular Immunology.

Detection of oxidative dna damage in human sperm and the association with cigarette smoking

C. Ong, Han-Ming Shen, B. Lee, 1997 .

Synergistic effects of autophagy/mitophagy inhibitors and magnolol promote apoptosis and antitumor efficacy

Jigang Wang, Han-Ming Shen, T. Yi, 2021, Acta pharmaceutica Sinica. B.

STX17 dynamically regulated by Fis1 induces mitophagy via hierarchical macroautophagic mechanism

Y. Liou, Qiaoyun Yang, Han-Ming Shen, 2019, Nature Communications.

Polyphyllin I induces mitophagic and apoptotic cell death in human breast cancer cells by increasing mitochondrial PINK1 levels

Han-Ming Shen, Cheng Huang, Jing Zhou, 2017, Oncotarget.

WIPI2 positively regulates mitophagy by promoting mitochondrial recruitment of VCP

Lei Fang, Weifeng He, D. Xia, 2022, Autophagy.

Garciesculenxanthone B induces PINK1-Parkin-mediated mitophagy and prevents ischemia-reperfusion brain injury in mice

Y. Lao, Han-Ming Shen, Liming Wang, 2020, Acta Pharmacologica Sinica.

Cadmium‐induced apoptosis and phenotypic changes in mouse thymocytes

C. Ong, Han-Ming Shen, S. Dong, 2001, Molecular and Cellular Biochemistry.

A JNK-mediated autophagy pathway that triggers c-IAP degradation and necroptosis for anticancer chemotherapy

X. Gou, Han-Ming Shen, B. Srinivasan, 2013, Oncogene.

AMPK mediates a pro‐survival autophagy downstream of PARP‐1 activation in response to DNA alkylating agents

S. Yao, Youtong Wu, Qing Huang, 2013, FEBS letters.

Critical role of GSH in silica-induced oxidative stress, cytotoxicity, and genotoxicity in alveolar macrophages.

Zhuo Zhang, C. Ong, Han-Ming Shen, 1999, American journal of physiology. Lung cellular and molecular physiology.

AMPK-Dependent Phosphorylation of GAPDH Triggers Sirt1 Activation and Is Necessary for Autophagy upon Glucose Starvation.

J. Lippincott-Schwartz, Tianhua Zhou, Han-Ming Shen, 2015, Molecular cell.

Anticancer effects of aloe‐emodin on HepG2 cells: Cellular and proteomic studies

M. Chung, Guo-Dong Lu, C. Ong, 2007, Proteomics. Clinical applications.

Terminalia Chebula provides protection against dual modes of necroptotic and apoptotic cell death upon death receptor ligation

Yoonjung Lee, Han-Ming Shen, Sora Lee, 2016, Scientific Reports.

Dual role of oxidative stress-JNK activation in autophagy and apoptosis induced by nickel oxide nanoparticles in human cancer cells.

B. Bay, Q. Saquib, Weifeng He, 2020, Free radical biology & medicine.

Lysosomal inhibition attenuates peroxisomal gene transcription via suppression of PPARA and PPARGC1A levels

Sujoy Ghosh, Han-Ming Shen, P. Yen, 2019, Autophagy.

Induction of autophagy by palmitic acid via protein kinase C-mediated signaling pathway independent of mTOR (mammalian target of rapamycin).

B. Bay, M. Wenk, G. Shui, 2014, The Journal of Biological Chemistry.

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

Mark R. Marten, Erinna F. Lee, Dana L. Miller, 2021, Autophagy.

Friend or Foe? Implication of the autophagy-lysosome pathway in SARS-CoV-2 infection and COVID-19

D. Xia, Han-Ming Shen, Jing Zhou, 2022, International journal of biological sciences.

Bone marrow stromal cell‐derived growth inhibitor serves as a stress sensor to induce autophagy

Jianbin Zhang, Jian Xu, D. Xia, 2020, FEBS letters.

Mechanistic Investigation of the Specific Anticancer Property of Artemisinin and Its Combination with Aminolevulinic Acid for Enhanced Anticolorectal Cancer Activity

Jigang Wang, Jianbin Zhang, T. Lim, 2017, ACS central science.

Exposure to acrylonitrile induced DNA strand breakage and sex chromosome aneuploidy in human spermatozoa.

C. Ong, Han-Ming Shen, De-xiang Xu, 2003, Mutation research.

Erratum to: Lu J-H, Tan J-Q, Durairajan SSK, Liu L-F, Zhang Z-H, Ma L, et al. Isorhynchophylline, a natural alkaloid, promotes the degradation of α-synuclein in neuronal cells via inducing autophagy. Autophagy 2012; 8:98–108

Han-Ming Shen, Zhuohua Zhang, Jiahong Lu, 2012 .

Death-associated Protein 3 Regulates Mitochondrial-encoded Protein Synthesis and Mitochondrial Dynamics*

Y. Liou, Han-Ming Shen, Hongyan Wang, 2015, The Journal of Biological Chemistry.

The Role of Autophagy in Liver Diseases: Mechanisms and Potential Therapeutic Targets

P. Codogno, A. Cuervo, R. Cursio, 2015, BioMed research international.

A novel autophagy/mitophagy inhibitor liensinine sensitizes breast cancer cells to chemotherapy through DNM1L-mediated mitochondrial fission

P. Li, Han-Ming Shen, Cheng Huang, 2015, Autophagy.

Down-regulation of c-FLIP contributes to the sensitization effect of 3,3′-diindolylmethane on TRAIL-induced apoptosis in cancer cells

Siyuan Zhang, C. Ong, Han-Ming Shen, 2005, Molecular Cancer Therapeutics.

Generation of transgenic zebrafish with liver-specific expression of EGFP-Lc3: a new in vivo model for investigation of liver autophagy.

Z. Gong, Han-Ming Shen, Jianzhou Cui, 2012, Biochemical and biophysical research communications.

mTOR S-nitrosylation inhibits autophagy and lysosomal proteolysis

K. Lim, S. Sajikumar, Sheeja Navakkode, 2020, bioRxiv.

Brazilin Limits Inflammatory Responses through Induction of Prosurvival Autophagy in Rheumatoid Fibroblast-Like Synoviocytes

Hyunji Lee, Han-Ming Shen, H. Byun, 2015, PloS one.

Autophagy is a cell self-protective mechanism against arsenic-induced cell transformation.

Tao Zhang, Xianglin Shi, Jia Luo, 2012, Toxicological sciences : an official journal of the Society of Toxicology.

Long non-coding RNA linc00673 regulated non-small cell lung cancer proliferation, migration, invasion and epithelial mesenchymal transition by sponging miR-150-5p

Han Wu, D. Xia, Han-Ming Shen, 2017, Molecular cancer.

Photodynamic therapy accelerates skin wound healing through promoting re-epithelialization

Michael R Hamblin, M. Hamblin, Y. Liou, 2021, Burns & trauma.

Metabolic signatures of four major histological types of lung cancer cells

B. Bay, C. Ong, Han-Ming Shen, 2018, Metabolomics.

Pharmacological inhibitors of autophagy as novel cancer therapeutic agents.

Han-Ming Shen, Qidong Hu, Cheng Wang, 2016, Pharmacological research.

Mito‐Bomb: Targeting Mitochondria for Cancer Therapy

S. Yao, Wei Huang, Lin Li, 2021, Advanced materials.

Anti-cancer potential of sesquiterpene lactones: bioactivity and molecular mechanisms.

Han-Ming Shen, Siyuan Zhang, C. Ong, 2005, Current medicinal chemistry. Anti-cancer agents.

Mono-2-ethylhexyl phthalate drives progression of PINK1-parkin-mediated mitophagy via increasing mitochondrial ROS to exacerbate cytotoxicity

P. Héroux, Jian Xu, D. Xia, 2020, Redox biology.

Critical role of AMPK in redox regulation under glucose starvation

Han-Ming Shen, Yi Ren, 2019, Redox biology.

Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum

Bin Liu, Chwee Teck Lim, Han-Ming Shen, 2015, Nature Communications.

The role of autophagy in liver cancer: molecular mechanisms and potential therapeutic targets.

Z. Gong, Han-Ming Shen, Jianzhou Cui, 2013, Biochimica et biophysica acta.

Luteolin , a flavonoid with potentials for cancer prevention and therapy

Han-Ming Shen, Y. Lin, Xia Wang, 2009 .

Critical role of pro-apoptotic Bcl-2 family members in andrographolide-induced apoptosis in human cancer cells.

Siyuan Zhang, C. Ong, Han-Ming Shen, 2006, Biochemical pharmacology.

In situ Proteomic Profiling of Curcumin Targets in HCT116 Colon Cancer Cell Line

Steven R. Tannenbaum, Han-Ming Shen, Yin Kwan Wong, 2016, Scientific Reports.

Critical role of oxidative stress and sustained JNK activation in aloe-emodin-mediated apoptotic cell death in human hepatoma cells.

M. Chung, Guo-Dong Lu, C. Ong, 2007, Carcinogenesis.

Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling.

S. Sze, P. Hao, S. Yao, 2013, Angewandte Chemie.

Essential Roles of Receptor-Interacting Protein and TRAF2 in Oxidative Stress-Induced Cell Death

M. Karin, T. Jin, Lufen Chang, 2004, Molecular and Cellular Biology.

Involvement of proapoptotic Bcl-2 family members in parthenolide-induced mitochondrial dysfunction and apoptosis.

Siyuan Zhang, C. Ong, Han-Ming Shen, 2004, Cancer letters.

Suppressed NF-κB and sustained JNK activation contribute to the sensitization effect of parthenolide to TNF-α-induced apoptosis in human cancer cells

Choon Nam Ong, Han-Ming Shen, Xianglin Shi, 2004 .

Targeting p53 as a therapeutic strategy in sensitizing TRAIL-induced apoptosis in cancer cells.

Han-Ming Shen, Jing Zhao, Yixin Lu, 2012, Cancer letters.

Hydrogen Sulfide Protects HUVECs against Hydrogen Peroxide Induced Mitochondrial Dysfunction and Oxidative Stress

Hong Wang, Han-Ming Shen, Yi-Zhun Zhu, 2013, PloS one.

Detection of apoptotic alterations in sperm in subfertile patients and their correlations with sperm quality.

C. Ong, Han-Ming Shen, Jun Dai, 2002, Human reproduction.

Curcumin targets the TFEB-lysosome pathway for induction of autophagy

Jiukun Jiang, Jigang Wang, Jianbin Zhang, 2016, Oncotarget.

Integrated and comparative miRNA analysis of starvation-induced autophagy in mouse embryonic fibroblasts.

Z. Gong, Han-Ming Shen, Jianzhou Cui, 2015, Gene.

Tumor Necrosis Factor-induced Nonapoptotic Cell Death Requires Receptor-interacting Protein-mediated Cellular Reactive Oxygen Species Accumulation*

S. Nedospasov, Han-Ming Shen, G. Hur, 2004, Journal of Biological Chemistry.

Activation of the PI3K-Akt-mTOR signaling pathway promotes necrotic cell death via suppression of autophagy

C. Ong, Youtong Wu, Hui-Ling Tan, 2009, Autophagy.

Epigenetic Regulation of Autophagy Beyond the Cytoplasm: A Review

Han-Ming Shen, Yin Shi, V. Gopalakrishnan, 2021, Frontiers in Cell and Developmental Biology.

Selenite-induced toxicity in cancer cells is mediated by metabolic generation of endogenous selenium nanoparticles.

P. Bao, Yong-guan Zhu, F. Martin, 2015, Journal of proteome research.

Luteolin induces G1 arrest in human nasopharyngeal carcinoma cells via the Akt-GSK-3β-Cyclin D1 pathway.

C. Ong, Han-Ming Shen, Jing Zhou, 2010, Cancer letters.

The Role of Autophagy in Liver Cancer: Crosstalk in Signaling Pathways and Potential Therapeutic Targets

Han-Ming Shen, Jianzhou Cui, L. Lim, 2020, Pharmaceuticals.

Cholesterol-enriched membrane micro-domaindeficiency induces doxorubicin resistancevia promoting autophagy in breast cancer

Liming Wang, Jianbin Zhang, D. Xia, 2021, Molecular therapy oncolytics.

Induction of Autophagy by Palmitic Acid via Protein Kinase C-mediated Signaling Pathway Independent of mTOR (Mammalian Target of Rapamycin)*

B. Bay, M. Wenk, G. Shui, 2012, The Journal of Biological Chemistry.

Cucurbitacin induces autophagy through mitochondrial ROS production which counteracts to limit caspase-dependent apoptosis

Yoonjung Lee, Han-Ming Shen, H. Byun, 2012, Autophagy.

Dual role of autophagy in hallmarks of cancer

T. Tan, R. Huang, B. Goh, 2018, Oncogene.

Oxidative stress-mediated AMPK inactivation determines the high susceptibility of LKB1-mutant NSCLC cells to glucose starvation.

Z. Ling, B. Bay, Han-Ming Shen, 2021, Free radical biology & medicine.

Synthetic lethality targeting LKB1 mutant and EGFR wild type human non-small cell lung cancer cells by glucose starvation and SGLT2 inhibition

Qiang Yu, You-Sun Kim, Han-Ming Shen, 2019, bioRxiv.

20(S)-Ginsenoside Rg3 is a novel inhibitor of autophagy and sensitizes hepatocellular carcinoma to doxorubicin

S. Kwon, K. Choi, You-Sun Kim, 2014, Oncotarget.

Andrographolide sensitizes cisplatin-induced apoptosis via suppression of autophagosome-lysosome fusion in human cancer cells

D. Xia, C. Ong, Han-Ming Shen, 2012, Autophagy.

Targeting CD82/KAI1 for Precision Therapeutics in Surmounting Metastatic Potential in Breast Cancer

B. Bay, Han-Ming Shen, G. Baeg, 2021, Cancers.

CRISPR system for genome engineering: the application for autophagy study

Yin Shi, Jianzhou Cui, Shirley Jia Li Chew, 2017, BMB reports.

Andrographolide simultaneously augments Nrf2 antioxidant defense and facilitates autophagic flux blockade in cigarette smoke‐exposed human bronchial epithelial cells

Han-Ming Shen, H. Peh, W. Wong, 2018, Toxicology and applied pharmacology.

Inhibition of the JAK-STAT3 pathway by andrographolide enhances chemosensitivity of cancer cells to doxorubicin.

C. Ong, Han-Ming Shen, G. Hur, 2010, Biochemical pharmacology.

Reactive Oxygen Species in Cell Fate Decisions

S. Pervaiz, Han-Ming Shen, 2009 .

Dysregulated autophagy in COPD: A pathogenic process to be deciphered.

W. Tan, W. Wong, Han-Ming Shen, 2019, Pharmacological research.

Modulation of Autophagy as a Novel Cancer Therapeutic Strategy

Han-Ming Shen, Jianzhou Cui, 2013 .

Impaired autophagy due to constitutive mTOR activation sensitizes TSC2-null cells to cell death under stress

Youtong Wu, Han-Ming Shen, Jing Zhou, 2011, Autophagy.

DUSP16 promotes cancer chemoresistance through regulation of mitochondria-mediated cell death

B. Goh, R. Dasgupta, I. Tan, 2021, Nature Communications.

Histone deacetylase inhibitors induce autophagy through FOXO1-dependent pathways

Jigang Wang, Jianbin Zhang, D. Xia, 2015, Autophagy.

Metabolic signatures of four major histological types of lung cancer cells

B. Bay, C. Ong, Han-Ming Shen, 2018, Metabolomics.

Differential regulatory functions of three classes of phosphatidylinositol and phosphoinositide 3-kinases in autophagy

Y. C. Long, Han-Ming Shen, Xinlei Yu, 2015, Autophagy.

The Long and the Short of PTEN in the Regulation of Mitophagy

Han-Ming Shen, Liming Wang, Guang Lu, 2020, Frontiers in Cell and Developmental Biology.

Long non-coding RNA linc00673 regulated non-small cell lung cancer proliferation, migration, invasion and epithelial mesenchymal transition by sponging miR-150-5p

Han Wu, D. Xia, Han-Ming Shen, 2017, Molecular Cancer.

Autophagy: resetting glutamine-dependent metabolism and oxygen consumption.

Yun-Ru Chen, D. Ann, R. Mohney, 2012, Autophagy.

Chemopreventive activity of parthenolide against UVB-induced skin cancer and its mechanisms.

Xianglin Shi, C. Ong, Han-Ming Shen, 2004, Carcinogenesis.

Anticancer Properties of Anthraquinones from Rhubarb

M. Chung, Guo-Dong Lu, C. Ong, 2007 .

Impairment of the autophagy–lysosomal pathway in Alzheimer's diseases: Pathogenic mechanisms and therapeutic potential

Jigang Wang, Han-Ming Shen, Chuanbin Yang, 2022, Acta pharmaceutica Sinica. B.

Is correction for protein concentration appropriate for protein adduct dosimetry? Hypothesis and clues from an aflatoxin B1‐exposed population

Zhi-ming Liu, R. Santella, C. Ong, 2007, Cancer science.

Hepatitis B virus infection contributes to oxidative stress in a population exposed to aflatoxin B1 and high-risk for hepatocellular carcinoma.

Zhi-ming Liu, R. Santella, C. Ong, 2008, Cancer letters.

Evaluation of oxidative stress in a group of adolescents exposed to a high level of aflatoxin B1--a multi-center and multi-biomarker study.

Zhi-ming Liu, R. Santella, C. Ong, 2007, Carcinogenesis.

Autophagy and Tumor Database: ATdb, a novel database connecting autophagy and tumor

Dexin Yang, Jinming Xu, Shengchao Wang, 2020, Database J. Biol. Databases Curation.

Autophagic Cell Death: A Real Killer, an Accomplice, or an Innocent Bystander?

Han-Ming Shen, S. Tan, 2014 .

Oxidative Stress in Cell Signaling and Cell Fate Determination Under Glucose Starvation

Han-Ming Shen, Yi Ren, Charlie Cheong, 2021, Oxidative Stress.

Parthenolide sensitizes ultraviolet (UV)-B-induced apoptosis via protein kinase C-dependent pathways.

C. Ong, Han-Ming Shen, Y. Won, 2005, Carcinogenesis.

Quantitative chemical proteomics profiling of de novo protein synthesis during starvation-mediated autophagy

Jigang Wang, Jianbin Zhang, Q. Lin, 2016, Autophagy.

TNF receptor superfamily‐induced cell death: redox‐dependent execution

S. Pervaiz, Han-Ming Shen, 2006, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Mapping sites of aspirin-induced acetylations in live cells by quantitative acid-cleavable activity-based protein profiling (QA-ABPP)

Jigang Wang, Jianbin Zhang, T. Lim, 2015, Scientific Reports.

A Quantitative Chemical Proteomics Approach to Profile the Specific Cellular Targets of Andrographolide, a Promising Anticancer Agent That Suppresses Tumor Metastasis*

Han-Ming Shen, Qingsong Lin, Jigang Wang, 2014, Molecular & Cellular Proteomics.

A Novel Scoring System for Pivotal Autophagy-Related Genes Predicts Outcomes after Chemotherapy in Advanced Ovarian Cancer Patients

D. Xia, Wenjie Sun, Han-Ming Shen, 2019, Cancer Epidemiology, Biomarkers & Prevention.

A small-molecule protein-protein interaction inhibitor of PARP1 that targets its BRCT domain.

S. Yao, Han-Ming Shen, Jun‐Seok Lee, 2015, Angewandte Chemie.

mTOR Complex 2 Targets Akt for Proteasomal Degradation via Phosphorylation at the Hydrophobic Motif*

Adam S. Lazorchak, Dou Liu, W. Ouyang, 2011, The Journal of Biological Chemistry.

Autophagy is a survival force via suppression of necrotic cell death.

P. Codogno, Han-Ming Shen, 2012, Experimental cell research.

Intracellular glutathione is a cofactor in methylseleninic acid-induced apoptotic cell death of human hepatoma HEPG(2) cells.

C. Ong, Han-Ming Shen, W. Ding, 2002, Free radical biology & medicine.

Luteolin sensitizes the anticancer effect of cisplatin via c-Jun NH2-terminal kinase–mediated p53 phosphorylation and stabilization

C. Ong, Qing Huang, Han-Ming Shen, 2007, Molecular Cancer Therapeutics.

Celastrol induces ferroptosis in activated HSCs to ameliorate hepatic fibrosis via targeting peroxiredoxins and HO-1

Han-Ming Shen, Piao Luo, Chuanbin Yang, 2021, Acta pharmaceutica Sinica. B.

Novel synthetic luteolin analogue-caused sensitization of tumor necrosis factor-alpha-induced apoptosis in human tumor cells.

Han-Ming Shen, Yixin Lu, Li‐Jie Cheng, 2008, Organic & biomolecular chemistry.

Target identification with quantitative activity based protein profiling (ABPP)

Han-Ming Shen, Yin Kwan Wong, Qingsong Lin, 2017, Proteomics.

Necrotic Cell Death

Han-Ming Shen, Peter Vandenabeele, P. Vandenabeele, 2014, Cell Death in Biology and Diseases.

Post-translational Modification in Control of SIRT1 Stability during DNA Damage Response

B. Bay, Han-Ming Shen, Guang Lu, 2022, International Journal of Biological Sciences.

Autophagy in Necrosis: A Force for Survival

P. Codogno, Han-Ming Shen, 2014 .

Autophagic cell death: Loch Ness monster or endangered species?

P. Codogno, Han-Ming Shen, 2011, Autophagy.

Artesunate Induces Cell Death in Human Cancer Cells via Enhancing Lysosomal Function and Lysosomal Degradation of Ferritin*

W. Wong, Han-Ming Shen, K. Tan, 2014, The Journal of Biological Chemistry.

Docetaxel enhances lysosomal function through TFEB activation

Yun Chen, Jigang Wang, Jianbin Zhang, 2018, Cell Death & Disease.

Critical role of SCD1 in autophagy regulation via lipogenesis and lipid rafts-coupled AKT-FOXO1 signaling pathway

D. Xia, Jingxiang Huang, M. Wenk, 2014, Autophagy.

Enhanced Autophagy from Chronic Toxicity of Iron and Mutant A53T α-Synuclein

K. Lim, T. Dawson, V. Dawson, 2011, The Journal of Biological Chemistry.

Quercetin induces p53‐independent cancer cell death through lysosome activation by the transcription factor EB and Reactive Oxygen Species‐dependent ferroptosis

Guo-Dong Lu, Han-Ming Shen, Guang Lu, 2020, British journal of pharmacology.

Recent advances in quantitative and chemical proteomics for autophagy studies

Jigang Wang, Jianbin Zhang, Q. Lin, 2017, Autophagy.

Erratum to: Long non-coding RNA linc00673 regulated non-small cell lung cancer proliferation, migration, invasion and epithelial mesenchymal transition by sponging miR-150-5p

Han Wu, D. Xia, Wenjie Sun, 2017, Molecular Cancer.

Targeting the potent Beclin 1–UVRAG coiled-coil interaction with designed peptides enhances autophagy and endolysosomal trafficking

Renxiao Wang, Yanxiang Zhao, Z. Yue, 2018, Proceedings of the National Academy of Sciences.

SAHA and cisplatin sensitize gastric cancer cells to doxorubicin by induction of DNA damage, apoptosis and perturbation of AMPK‐mTOR signalling

Y. C. Long, B. Dymock, E. Lee, 2018, Experimental cell research.

PTEN-L puts a brake on mitophagy

Jigang Wang, Han-Ming Shen, Liming Wang, 2018, Autophagy.

PTEN-L is a novel protein phosphatase for ubiquitin dephosphorylation to inhibit PINK1–Parkin-mediated mitophagy

K. Lim, B. Bay, Hanry Yu, 2018, Cell Research.

Author Correction: STX17 dynamically regulated by Fis1 induces mitophagy via hierarchical macroautophagic mechanism

Y. Liou, Qiaoyun Yang, Han-Ming Shen, 2019, Nature Communications.

Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

Sara W. Bird, Erinna F. Lee, Michael D. Kim, 2016 .

PPARγ Ligand-induced Annexin A1 Expression Determines Chemotherapy Response via Deubiquitination of Death Domain Kinase RIP in Triple-negative Breast Cancers.

T. Tan, J. E. Kim, B. Goh, 2017, Molecular cancer therapeutics.

Methyl-3-indolylacetate inhibits cancer cell invasion by targeting the MEK1/2-ERK1/2 signaling pathway

Ximei Wu, Siyuan Zhang, C. Ong, 2006, Molecular Cancer Therapeutics.

c-Jun N-terminal kinase mediates hydrogen peroxide-induced cell death via sustained poly(ADP-ribose) polymerase-1 activation

M. Hande, Y. Lin, Siyuan Zhang, 2007, Cell Death and Differentiation.

Dual suppressive effect of MTORC1 on autophagy

P. Codogno, Han-Ming Shen, Jing Zhou, 2013, Autophagy.

PPARγ Ligand–induced Annexin A1 Expression Determines Chemotherapy Response via Deubiquitination of Death Domain Kinase RIP in Triple-negative Breast Cancers

T. Tan, J. E. Kim, B. Goh, 2017, Molecular Cancer Therapeutics.

Epigenetic silencing of glutaminase 2 in human liver and colon cancers

Y. Zhong, Jianbin Zhang, D. Xia, 2013, BMC Cancer.

Chronically high level of tgfb1a induction causes both hepatocellular carcinoma and cholangiocarcinoma via a dominant Erk pathway in zebrafish

Z. Gong, Han-Ming Shen, Qiqi Yang, 2017, Oncotarget.

PPAR g Ligand – induced Annexin A1 Expression Determines Chemotherapy Response via Deubiquitination of Death Domain Kinase RIP in Triple-negative Breast Cancers

T. Tan, J. E. Kim, B. Goh, 2017 .

Critical role of CAV1/caveolin-1 in cell stress responses in human breast cancer cells via modulation of lysosomal function and autophagy

R. Parton, You-Sun Kim, Han-Ming Shen, 2015, Autophagy.

Dual role of autophagy in hallmarks of cancer

T. Tan, R. Huang, B. Goh, 2018, Oncogene.

AMPK mediates a pro‐survival autophagy downstream of PARP‐1 activation in response to DNA alkylating agents

Youtong Wu, Qing Huang, Han-Ming Shen, 2013, FEBS letters.

Seeing is believing: a novel tool for quantitating mitophagy

Han-Ming Shen, Liming Wang, 2020, Cell Research.

FBS or BSA Inhibits EGCG Induced Cell Death through Covalent Binding and the Reduction of Intracellular ROS Production

Han-Ming Shen, Jun Yang, Yi-fan Zheng, 2016, BioMed research international.

Artemisinin as an anticancer drug: Recent advances in target profiling and mechanisms of action

Karunakaran A Kalesh, W. Wong, Jigang Wang, 2017, Medicinal research reviews.

Oblongifolin C suppresses lysosomal function independently of TFEB nuclear translocation

Y. Lao, Han-Ming Shen, Guang Lu, 2018, Acta Pharmacologica Sinica.

Isorhynchophylline, a natural alkaloid, promotes the degradation of alpha-synuclein in neuronal cells via inducing autophagy

Han-Ming Shen, Jiahong Lu, Min Li, 2012, Autophagy.

Mechanism-Guided Design and Synthesis of a Mitochondria-Targeting Artemisinin Analogue with Enhanced Anticancer Activity.

B. Liu, Jigang Wang, Jianbin Zhang, 2016, Angewandte Chemie.

IKKβ programs to turn on the GADD45α–MKK4–JNK apoptotic cascade specifically via p50 NF-κB in arsenite response

Q. Zhan, Jingxia Li, Chuanshu Huang, 2006, The Journal of cell biology.