M. Wientjes

发表

Delivery of siRNA Therapeutics: Barriers and Carriers

J. Au, Jie Wang, Ze Lu, 2010, The AAPS Journal.

Delivery of cancer therapeutics to extracellular and intracellular targets: Determinants, barriers, challenges and opportunities.

Ze Lu, Jessie L.-S. Au, M. Guillaume Wientjes, 2016, Advanced drug delivery reviews.

Physiologically Based Pharmacokinetic Models of 2′,3′-Dideoxyinosine

J. Au, M. Wientjes, H. K. Kang, 1997, Pharmaceutical Research.

Simultaneous targeting of telomeres and telomerase as a cancer therapeutic approach.

J. Au, M. Wientjes, Y. Mo, 2003, Cancer research.

Cultured human bladder tumors for pharmacodynamic studies.

Thomas D. Schmittgen, J. Drago, R. Badalament, 1991, The Journal of urology.

Tumor Priming Enhances Delivery and Efficacy of Nanomedicines

J. Au, Ze Lu, M. Wientjes, 2007, Journal of Pharmacology and Experimental Therapeutics.

Pharmacologic effects of paclitaxel in human bladder tumors

Jessie L.-S. Au, M. Guillaume Wientjes, J. Au, 1997, Cancer Chemotherapy and Pharmacology.

Paclitaxel gelatin nanoparticles for intravesical bladder cancer therapy.

V. Bergdall, J. Au, Jie Wang, 2011, The Journal of urology.

Intraperitoneal therapy for peritoneal cancer.

J. Au, Jie Wang, Ze Lu, 2010, Future oncology.

Effect of dimethyl sulfoxide on bladder tissue penetration of intravesical paclitaxel.

J. Au, M. Wientjes, Danny Chen, 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

Effect of Dimethyl Sulfoxide on Bladder Tissue Penetration of Intravesical Paclitaxel 1

J. Au, M. Wientjes, Danny Chen, 2003 .

Cremophor reduces paclitaxel penetration into bladder wall during intravesical treatment

J. Au, M. Wientjes, Ian Knemeyer, 1999, Cancer Chemotherapy and Pharmacology.

Relationship between paclitaxel activity and pathobiology of human solid tumors.

M. Wientjes, J. L. Au, Y. Gan, 1998, Clinical cancer research : an official journal of the American Association for Cancer Research.

Differential Time Dependency of and Apoptotic Effects of Taxol in Prostate Tumors Antiproliferative Human

C. Chen, M. Wientjes, Y. Gan, 1997 .

Pharmacokinetics of intravesical mitomycin C in superficial bladder cancer patients.

J. Drago, R. Badalament, J. Dalton, 1991, Cancer research.

Pharmacodynamics of mitomycin C in cultured human bladder tumors.

Thomas D. Schmittgen, R. Badalament, M. Wientjes, 1991, Cancer research.

Penetration of mitomycin C in human bladder.

R. Badalament, M. Wientjes, J. L. Au, 1993, Cancer research.

Penetration of intravesical doxorubicin in human bladders

R. Badalament, J. Au, M. Wientjes, 1996, Cancer Chemotherapy and Pharmacology.

Pharmacodynamics of doxorubicin in human bladder tumors.

R. Badalament, M. Wientjes, J. L. Au, 1996, Clinical cancer research : an official journal of the American Association for Cancer Research.

Penetration Kinetics of 2′,3′-Dideoxyinosine in Dermis Is Described by the Distributed Model

J. Au, M. Wientjes, E. Gupta, 2004, Pharmaceutical Research.

Predictive Models of Diffusive Nanoparticle Transport in 3-Dimensional Tumor Cell Spheroids

Bin Chen, Jessie L.-S. Au, M. Guillaume Wientjes, 2013, The AAPS Journal.

Target Site Delivery and Residence of Nanomedicines: Application of Quantitative Systems Pharmacology

J. Au, Ze Lu, M. Wientjes, 2019, Pharmacological Reviews.

Relationships between Liposome Properties, Cell Membrane Binding, Intracellular Processing, and Intracellular Bioavailability

J. Au, Jie Wang, M. Wientjes, 2011, The AAPS Journal.

Phase I/II trial of non-cytotoxic suramin in combination with weekly paclitaxel in metastatic breast cancer treated with prior taxanes

M. Grever, B. Ramaswamy, C. Shapiro, 2012, Cancer Chemotherapy and Pharmacology.

Suramin as a Chemosensitizer: Oral Pharmacokinetics in Rats

J. Au, M. Wientjes, A. Ogden, 2004, Pharmaceutical Research.

Delivery of nanomedicines to extracellular and intracellular compartments of a solid tumor.

J. Au, Jie Wang, M. Wientjes, 2012, Advanced drug delivery reviews.

Drug Delivery and Transport to Solid Tumors

Jessie L.-S. Au, M. Guillaume Wientjes, Dan Lu, 2003, Pharmaceutical Research.

Paclitaxel tumor priming promotes delivery and transfection of intravenous lipid-siRNA in pancreatic tumors.

Bertrand Z. Yeung, J. Au, Jie Wang, 2015, Journal of controlled release : official journal of the Controlled Release Society.

Formulating Paclitaxel in Nanoparticles Alters Its Disposition

J. Au, Ze Lu, M. Wientjes, 2005, Pharmaceutical Research.

Pharmacodynamics of doxorubicin in human prostate tumors.

M. Wientjes, J. L. Au, C. T. Chen, 1998, Clinical cancer research : an official journal of the American Association for Cancer Research.

Fibroblast growth factors: an epigenetic mechanism of broad spectrum resistance to anticancer drugs.

J. Au, M. Wientjes, J. L. Au, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Pharmacodynamics of taxol in human head and neck tumors.

M. Wientjes, D. Schuller, J. L. Au, 1996, Cancer research.

Nontoxic doses of suramin enhance activity of paclitaxel against lung metastases.

M. Wientjes, J. L. Au, S. Song, 2001, Cancer research.

Computational model of intracellular pharmacokinetics of paclitaxel.

M. Wientjes, H. Kuh, J. L. Au, 2000, The Journal of pharmacology and experimental therapeutics.

Interdependent Effect of P-Glycoprotein-Mediated Drug Efflux and Intracellular Drug Binding on Intracellular Paclitaxel Pharmacokinetics: Application of Computational Modeling

J. Au, M. Wientjes, S. Jang, 2003, Journal of Pharmacology and Experimental Therapeutics.

Antiproliferative and Cytotoxic Effects of Geldanamycin, Cytochalasin E, Suramin and Thiacetazone in Human Prostate Xenograft Tumor Histocultures

Jie Lu, J. Au, M. Wientjes, 1998, Pharmaceutical Research.

Pentostatin in steroid-refractory acute graft-versus-host disease.

M. Grever, J. Byrd, J. Bolaños-Meade, 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Telomere maintenance in telomerase‐positive human ovarian SKOV‐3 cells cannot be retarded by complete inhibition of telomerase

Jie Lu, J. Au, M. Wientjes, 2002, FEBS Letters.

Its Effect on Melphalan-induced Toxicity in Mice Pharmacokinetics of Buthionine Sulfoximine ( NSC 326231 ) and Updated Version

M. Wientjes, Adaline C. Smith, C. Grieshaber, 2006 .

Pharmacokinetics of buthionine sulfoximine (NSC 326231) and its effect on melphalan-induced toxicity in mice.

M. Wientjes, C. Grieshaber, A. Smith, 1989, Cancer research.

Nonlinear Disposition of Intravenous 2′,3′-Dideoxyinosine in Rats

J. Au, M. Wientjes, E. Mukherji, 1992, Pharmaceutical Research.

Development of drug-loaded particles for intraperitoneal therapy

J. Au, Ze Lu, M. Wientjes, 2015 .

Method to Assess Interactivity of Drugs with Nonparallel Concentration‐Effect Relationships

J. Au, M. Wientjes, Liang Zhao, 2017, Current cancer drug targets.

Effects of bladder resorption on pharmacokinetic data analysis

J. Dalton, J. Au, M. Wientjes, 1994, Journal of Pharmacokinetics and Biopharmaceutics.

Regional heterogeneity and pharmacodynamics in human solid tumor histoculture

J. Au, M. Wientjes, J. R. Weaver, 1999, Cancer Chemotherapy and Pharmacology.

Low-Dose Suramin Enhanced Paclitaxel Activity in Chemotherapy-Naïve and Paclitaxel-Pretreated Human Breast Xenograft Tumors

J. Au, M. Wientjes, Yong Wei, 2004, Clinical Cancer Research.

Synergy Between 3′Azido-3′deoxythymidine and Paclitaxel in Human Pharynx FaDu Cells

Jeffrey S. Johnston, J. Au, M. Wientjes, 2003, Pharmaceutical Research.

Computational Model of Intracellular Pharmacokinetics of Paclitaxel 1

M. Wientjes, H. Kuh, S. Jang, 2000 .

Phase I evaluation of low-dose suramin as chemosensitizer of doxorubicin in dogs with naturally occurring cancers.

C. Couto, J. Au, M. Wientjes, 2006, Journal of veterinary internal medicine.

Postoperative adjuvant combination therapy with doxorubicin and noncytotoxic suramin in dogs with appendicular osteosarcoma.

J. Au, M. Wientjes, W. Kisseberth, 2014, Journal of the American Animal Hospital Association.

Tissue pharmacokinetics of 2',3'-dideoxyinosine in rats.

M. Wientjes, J. L. Au, H. Kang, 1994, Biochemical pharmacology.

Arsenic distribution in rabbits after Lewisite administration and treatment with British anti-Lewisite (BAL).

M. Wientjes, G. Fisher, R. Joiner, 1990, Fundamental and applied toxicology : official journal of the Society of Toxicology.

Pharmacokinetics of Oral 2′,3′-Dideoxyinosine in Rats

M. Wientjes, Jessie L.-S. Au, 1992, Pharmaceutical Research.

Evaluation of Combination Chemotherapy

J. Au, M. Wientjes, Jessie L-S Au, 2004, Clinical Cancer Research.

Computational Modeling to Predict Effect of Treatment Schedule on Drug Delivery to Prostate in Humans

J. Au, M. Wientjes, Leijun Hu, 2007, Clinical Cancer Research.

Bladder tissue pharmacokinetics and antitumor effect of intravesical 5-fluorouridine.

M. Wientjes, J. L. Au, Y. Gan, 1997, Clinical cancer research : an official journal of the American Association for Cancer Research.

Bladder tissue pharmacokinetics of intravesical taxol

M. Guillaume Wientjes, J. Au, M. Wientjes, 1997, Cancer Chemotherapy and Pharmacology.

Comparison of methods for evaluating drug-drug interaction.

J. Au, M. Wientjes, Jessie L-S Au, 2010, Frontiers in bioscience.

Paclitaxel-loaded polymeric microparticles: quantitative relationships between in vitro drug release rate and in vivo pharmacodynamics.

J. Au, Ze Lu, M. Wientjes, 2013, Journal of controlled release : official journal of the Controlled Release Society.

Reversed-phase ion-pair high-performance liquid chromatographic assay of 5-fluorouracil, 5'-deoxy-5-fluorouridine, their nucleosides, mono-, di-, and triphosphate nucleotides with a mixture of quaternary ammonium ions.

Y. Rustum, M. Wientjes, J. L. Au, 1982, Journal of chromatography.

Correlation of human bladder tumor histoculture proliferation and sensitivity to mitomycin C with tumor pathobiology.

Thomas D. Schmittgen, E. Klein, R. Badalament, 1994, The Journal of urology.

Bladder wall penetration of intravesical mitomycin C in dogs.

J. Drago, R. Badalament, J. Dalton, 1991, Cancer research.

Absorption of 2′, 3′-Dideoxyinosine from Lower Gastrointestinal Tract in Rats and Kinetic Evidence of Different Absorption Rates in Colon and Rectum

J. Au, M. Wientjes, S. Bramer, 1993, Pharmaceutical Research.

Gastrointestinal and hepatic first-pass elimination of 2',3'-dideoxyinosine in rats.

M. Wientjes, J. L. Au, S. Bramer, 1993, The Journal of pharmacology and experimental therapeutics.

Pharmacokinetics of 2′,3′-dideoxyadenosine in dogs

M. Wientjes, J. Tomaszewski, W. Kluwe, 1991, Investigational New Drugs.

Lack of pharmacokinetic interaction between intravenous 2',3'-dideoxyinosine and 3'-azido-3'-deoxythymidine in rats

M. Wientjes, J. L. Au, 1992, Antimicrobial Agents and Chemotherapy.

Extensive Absorption of 2′,3′-Dideoxyinosine by Intratracheal Administration in Rats

J. Au, M. Wientjes, Xiang Gao, 1995, Pharmaceutical Research.

Intravesical Treatments of Bladder Cancer: Review

J. Au, M. Wientjes, M. O'Donnell, 2008, Pharmaceutical Research.

High-performance liquid chromatographic analysis of 2',3'-dideoxyinosine in biological samples.

M. Wientjes, J. L. Au, 1991, Journal of chromatography.

Quantitative image analysis of intra-tumoral bFGF level as a molecular marker of paclitaxel resistance

M. Wientjes, Yong Wei, Yong Wei, 2008, Journal of Translational Medicine.

A Method to Study Drug Concentration–Depth Profiles in Tissues: Mitomycin C in Dog Bladder Wall

J. Drago, R. Badalament, J. Dalton, 1991, Pharmaceutical Research.

Tumor priming enhances siRNA delivery and transfection in intraperitoneal tumors.

Bertrand Z. Yeung, J. Au, Jie Wang, 2014, Journal of controlled release : official journal of the Controlled Release Society.

Intravenous siRNA Silencing of Survivin Enhances Activity of Mitomycin C in Human Bladder RT4 Xenografts.

K. Loughlin, J. Au, Ze Lu, 2015, The Journal of urology.

Paclitaxel tumor-priming enhances siRNA delivery and transfection in 3-dimensional tumor cultures.

J. Au, Ze Lu, M. Wientjes, 2011, Molecular pharmaceutics.

Differential Effect of Taxol in Rat Primary and Metastatic Prostate Tumors: Site-Dependent Pharmacodynamics

J. Au, M. Wientjes, W. Yen, 1996, Pharmaceutical Research.

Histocultures of Patient Head and Neck Tumors for Pharmacodynamics Studies

T. Rosol, M. Wientjes, D. Schuller, 1993, Pharmaceutical Research.

Histocultures of human prostate tissues for pharmacologic evaluation.

R. Badalament, T. Pretlow, M. Wientjes, 1995, The Journal of urology.

Androgen-dependent and -independent human prostate xenograft tumors as models for drug activity evaluation.

C. Chen, M. Wientjes, J. L. Au, 1998, Cancer research.

A Quantitative Pharmacology Model of Exosome-Mediated Drug Efflux and Perturbation-Induced Synergy

Bertrand Z. Yeung, J. Au, Ze Lu, 2021, Pharmaceutics.

Kinetics of P-glycoprotein-mediated efflux of paclitaxel.

M. Wientjes, J. L. Au, S. Jang, 2001, The Journal of pharmacology and experimental therapeutics.

Phase I study of low-dose suramin as a chemosensitizer in patients with advanced non-small cell lung cancer.

M. Grever, G. Otterson, M. Villalona-Calero, 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

Bladder Tissue Pharmacokinetics of Intravesical Mitomycin C and Suramin in Dogs

J. Au, M. Wientjes, Leijun Hu, 2010, The AAPS Journal.

Determinants of Paclitaxel Uptake, Accumulation and Retention in Solid Tumors

Jessie L.-S. Au, M. Guillaume Wientjes, J. Au, 2001, Investigational New Drugs.

A Quantitative Assay of Telomerase Activity

Jie Lu, J. Au, M. Wientjes, 2001, Pharmaceutical Research.

Pharmacodynamics of Telomerase Inhibition and Telomere Shortening by Noncytotoxic Suramin

Bertrand Z. Yeung, Jie Lu, J. Au, 2014, The AAPS Journal.

Predictive Models of Diffusive Nanoparticle Transport in 3-Dimensional Tumor Cell Spheroids

Bin Chen, J. Au, M. Wientjes, 2013, The AAPS Journal.

Low dose suramin as a chemosensitizer of bladder cancer to mitomycin C.

M. Wientjes, Danny Chen, Y. Xin, 2005, The Journal of urology.

Expression of Basic Fibroblast Growth Factor Correlates with Resistance to Paclitaxel in Human Patient Tumors

J. Au, M. Wientjes, Y. Gan, 2006, Pharmaceutical Research.

Pancreatic Cancer: Pathobiology, Treatment Options, and Drug Delivery

J. Au, M. Wientjes, Jing Li, 2010, The AAPS Journal.

Multiscale Tumor Spatiokinetic Model for Intraperitoneal Therapy

Ze Lu, Jessie L.-S. Au, M. Guillaume Wientjes, 2014, The AAPS Journal.

6. Intravesical chemotherapy

J. Au, M. Wientjes, L. Türkeri, 2015 .

Biodegradable intraprostatic doxorubicin implants

Ze Lu, M. Guillaume Wientjes, J. Au, 2007, The AAPS Journal.

Pharmacodynamics of Doxorubicin in Human Prostate Tumors 1

C. Chen, J. Au, M. Wientjes, 2005 .

Pharmacodynamics of immediate and delayed effects of paclitaxel: role of slow apoptosis and intracellular drug retention.

M. Wientjes, H. Kuh, J. L. Au, 1998, Cancer research.

Determinants of paclitaxel penetration and accumulation in human solid tumor.

M. Wientjes, H. Kuh, J. L. Au, 1999, The Journal of pharmacology and experimental therapeutics.

Improving delivery and efficacy of nanomedicines in solid tumors: role of tumor priming.

Ze Lu, J. Au, Jie Wang, 2011, Nanomedicine.

Effects of Carrier on Disposition and Antitumor Activity of Intraperitoneal Paclitaxel

Ze Lu, Jessie L.-S. Au, M. Guillaume Wientjes, 2007, Pharmaceutical Research.

Intravesical chemotherapy of superficial bladder cancer: optimization and novel agents

J. Au, M. Wientjes, 2008 .

Systemic Bioequivalence Is Unlikely to Equal Target Site Bioequivalence for Nanotechnology Oncologic Products

J. Au, Ze Lu, M. Wientjes, 2019, The AAPS Journal.

Tumor-Penetrating Microparticles for Intraperitoneal Therapy of Ovarian Cancer

Ze Lu, Max Tsai, Dan Lu, 2008, Journal of Pharmacology and Experimental Therapeutics.

Enhancement of paclitaxel delivery to solid tumors by apoptosis-inducing pretreatment: effect of treatment schedule.

M. Wientjes, J. L. Au, S. Jang, 2001, The Journal of pharmacology and experimental therapeutics.

Bladder tissue uptake of mitomycin C during intravesical therapy is linear with drug concentration in urine.

R. Badalament, M. Wientjes, J. L. Au, 1998, Clinical cancer research : an official journal of the American Association for Cancer Research.

Is It Time to Use Modeling of Cellular Transporter Homeostasis to Inform Drug-Drug Interaction Studies: Theoretical Considerations

J. Au, M. Wientjes, R. Abbiati, 2021, The AAPS Journal.

Versatility of Particulate Carriers: Development of Pharmacodynamically Optimized Drug-Loaded Microparticles for Treatment of Peritoneal Cancer

J. Au, Ze Lu, M. Wientjes, 2015, The AAPS Journal.

Activity of drug-loaded tumor-penetrating microparticles in peritoneal pancreatic tumors.

J. Au, Jie Wang, Ze Lu, 2014, Current cancer drug targets.

Evidence of significant absorption of sodium salicylate from urinary bladder of rats.

J. Dalton, M. Wientjes, J. L. Au, 1991, Journal of Pharmacology and Experimental Therapeutics.

832: Optimized Intravesical Mitomycin C Treatment for Superficial Bladder Cancer: Long-Term Follow-Up

J. Chin, R. Badalament, B. Miles, 2006 .

Nontoxic Suramin as a Chemosensitizer in Patients: Dosing Nomogram Development

M. Grever, G. Otterson, M. Villalona-Calero, 2006, Pharmaceutical Research.

Enhanced Drug-Induced Apoptosis Associated with P-Glycoprotein Overexpression Is Specific to Antimicrotubule Agents

Jonghan Kim, J. Au, M. Wientjes, 2004, Pharmaceutical Research.

bFGF as a therapeutic target for chemosensitization in colorectal cancer.

J. Au, M. Wientjes, Yong Wei, 2006 .

Intraprostatic Chemotherapy: Distribution and Transport Mechanisms

J. Au, M. Wientjes, Jenny H. Zheng, 2005, Clinical Cancer Research.

Predicting diffusive transport of cationic liposomes in 3-dimensional tumor spheroids.

Ze Lu, Bertrand Z. Yeung, J. Au, 2014, Journal of controlled release : official journal of the Controlled Release Society.

Expression of DT-diaphorase and cytochrome P450 reductase correlates with mitomycin C activity in human bladder tumors.

K. Danenberg, P. Danenberg, M. Wientjes, 2001, Clinical Cancer Research.

Versatility of Particulate Carriers: Development of Pharmacodynamically Optimized Drug-Loaded Microparticles for Treatment of Peritoneal Cancer

J. Au, Ze Lu, M. Wientjes, 2015, The AAPS Journal.

Multiscale Tumor Spatiokinetic Model for Intraperitoneal Therapy

J. Au, Ze Lu, M. Wientjes, 2014, The AAPS Journal.

Abstract 5453: Drug transport in peritoneal tumors during intraperitoneal therapy – evaluation by computational model

J. Au, Ze Lu, M. Wientjes, 2011 .

Nonlinear pharmacokinetics of aspirin in rats.

M. Wientjes, G. Levy, 1988, The Journal of pharmacology and experimental therapeutics.

RESPONSE: Re: Methods to Improve Efficacy of Intravesical Mitomycin C: Results of a Randomized Phase III Trial

J. Au, M. Wientjes, 2001 .

Accuracy and Precision of Pharmacodynamic Exponent

J. Au, M. Wientjes, N. Millenbaugh, 2004, Pharmaceutical Research.

A pharmacodynamic analysis method to determine the relative importance of drug concentration and treatment time on effect

J. Au, M. Wientjes, N. Millenbaugh, 2000, Cancer Chemotherapy and Pharmacology.

Combination intravesical hyperthermia and chemotherapy for bladder cancer.

J. Au, M. Wientjes, 2010, Oncology.

Pharmacokinetic Interaction Between Intravenous 2′,3′-Dideoxyinosine and Pentamidine in Rats

J. Au, M. Wientjes, T. Yeh, 1996, Pharmaceutical Research.

Phase I evaluation of low-dose suramin as chemosensitizer of doxorubicin in dogs with naturally occurring cancers.

J. Au, M. Wientjes, W. Kisseberth, 2006, Journal of veterinary internal medicine.

Postoperative adjuvant combination therapy with doxorubicin and noncytotoxic suramin in dogs with appendicular osteosarcoma.

J. Au, M. Wientjes, W. Kisseberth, 2014, Journal of the American Animal Hospital Association.

Delivery of nanomedicines to extracellular and intracellular compartments of a solid tumor.

J. Au, Jie Wang, M. Wientjes, 2012, Advanced drug delivery reviews.

Systemic Bioequivalence Is Unlikely to Equal Target Site Bioequivalence for Nanotechnology Oncologic Products

Ze Lu, Jessie L.-S. Au, Roberto A. Abbiati, 2019, The AAPS Journal.

Tumor-Penetrating Microparticles for Intraperitoneal Therapy of Ovarian Cancer

J. Au, Jie Wang, Ze Lu, 2008, Journal of Pharmacology and Experimental Therapeutics.

Surgical management of peritoneal metastasis: Opportunities for pharmaceutical research.

J. Au, Ze Lu, M. Wientjes, 2023, Journal of controlled release : official journal of the Controlled Release Society.

Penetration of Mitomycin C in Human Bladder1

R. Badalament, J. Au, M. Wientjes, 2006 .

Considerations for the Forced Expiratory Volume in 1 Second‐Based Comparative Clinical Endpoint Bioequivalence Studies for Orally Inhaled Drug Products

A. Babiskin, R. Walenga, M. Wientjes, 2022, Clinical pharmacology and therapeutics.