N. Otto

发表

mTOR regulation of autophagy

Chang Hwa Jung, Do-Hyung Kim, Chang Hwa Jung, 2010, FEBS letters.

Concurrent transposon engineering and CRISPR/Cas9 genome editing of primary CLL-1 chimeric antigen receptor-natural killer cells.

N. Otto, M. Gurney, J. Krawczyk, 2022, Cytotherapy.

ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery.

C. Jung, M. Kundu, Do-Hyung Kim, 2009, Molecular biology of the cell.

GABARAPs and LC3s have opposite roles in regulating ULK1 for autophagy induction

Ji-man Park, Do-Hyung Kim, N. Otto, 2020, Autophagy.

Vicinal glutamates are better phosphomimetics: Phosphorylation is required for allosteric activation of guanylyl cyclase-A

N. Otto, L. Potter, 2022, Frontiers in Molecular Neuroscience.

Skeletal overgrowth-causing mutations mimic an allosterically activated conformation of guanylyl cyclase-B that is inhibited by 2,4,6,-trinitrophenyl ATP

N. Otto, D. Dickey, L. Potter, 2017, The Journal of Biological Chemistry.

A Glutamate-Substituted Mutant Mimics the Phosphorylated and Active Form of Guanylyl Cyclase-A

N. Otto, W. McDowell, D. Dickey, 2017, Molecular Pharmacology.

Catalytically Active Guanylyl Cyclase B Requires Endoplasmic Reticulum-mediated Glycosylation, and Mutations That Inhibit This Process Cause Dwarfism*

N. Otto, D. Dickey, J. Robinson, 2016, The Journal of Biological Chemistry.

ULK1 inhibits the kinase activity of mTORC1 and cell proliferation

C. Jung, Do-Hyung Kim, N. Otto, 2011, Autophagy.

ULK1 phosphorylates Ser30 of BECN1 in association with ATG14 to stimulate autophagy induction

M. Kyba, T. Griffin, Ji-man Park, 2018, Autophagy.

ULK 1 inhibits the kinase activity of mTORC 1 and cell proliferation

C. Jung, Do-Hyung Kim, N. Otto, 2012 .

The ULK1 complex mediates MTORC1 signaling to the autophagy initiation machinery via binding and phosphorylating ATG14

D. Voytas, B. Moriarity, R. Nho, 2016, Autophagy.