H. Nishitoh

发表

CHOP is a multifunctional transcription factor in the ER stress response.

H. Nishitoh, 2012, Journal of biochemistry.

Mammalian thioredoxin is a direct inhibitor of apoptosis signal‐regulating kinase (ASK) 1

Kohei Miyazono, K. Miyazono, M. Kawabata, 1998, The EMBO journal.

ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis

T Takahashi, T. Noda, K. Miyazono, 2001, EMBO reports.

Growth/differentiation factor-5 induces angiogenesis in vivo.

K. Miyazono, I. Morita, A. Hanyu, 1997, Experimental cell research.

STT3B-dependent posttranslational N-glycosylation as a surveillance system for secretory protein.

M. Taura, M. Suico, T. Shuto, 2012, Molecular cell.

ASK3 responds to osmotic stress and regulates blood pressure by suppressing WNK1-SPAK/OSR1 signaling in the kidney

H. Ichijo, Y. Shimizu, K. Kataoka, 2012, Nature Communications.

Activation of apoptosis signal-regulating kinase 1 (ASK1) by the adapter protein Daxx.

D. Baltimore, Xiaolu Yang, H. Ichijo, 1998, Science.

TargetingASK1inERstress-related neurodegenerativediseases

H. Ichijo, H. Nishitoh, Kengo Homma, 2009 .

Targeting ASK1 in ER stress-related neurodegenerative diseases

H. Ichijo, H. Nishitoh, Kengo Homma, 2009, Expert opinion on therapeutic targets.

Apoptosis signal-regulating kinase 1-mediated signaling pathway regulates hydrogen peroxide-induced apoptosis in human pulmonary vascular endothelial cells

T. Horie, H. Ichijo, H. Nishitoh, 2003, Critical care medicine.

Apoptosis signal-regulating kinase 1-mediated signaling pathway regulates nitric oxide-induced activator protein-1 activation in human bronchial epithelial cells.

T. Horie, H. Ichijo, H. Nishitoh, 2003, American journal of respiratory and critical care medicine.

Map Kinases in Redox Signaling

H. Ichijo, K. Takeda, H. Nishitoh, 2003 .

ASK1 Inhibits Interleukin-1-induced NF-κB Activity through Disruption of TRAF6-TAK1 Interaction*

K. Matsumoto, J. Ninomiya-Tsuji, Kunihiro Matsumoto, 2000, The Journal of Biological Chemistry.

Pre-emptive Quality Control Protects the ER from Protein Overload via the Proximity of ERAD Components and SRP.

Takashi Sato, H. Kai, T. Natsume, 2015, Cell reports.

Amyloid β induces neuronal cell death through ROS-mediated ASK1 activation

F. Urano, H. Masutani, J. Yodoi, 2005, Cell Death and Differentiation.

ER Quality Control and ER Stress-induced Cell Death in Neurodegenerative Diseases

H. Nishitoh, H. Kadowaki, Atsushi Nagai, 2007 .

Survival and apoptosis signals in ER stress: the role of protein kinases

H. Ichijo, H. Nishitoh, H. Kadowaki, 2004, Journal of Chemical Neuroanatomy.

The Cytoplasmic Domain of Alzheimer's Amyloid-β Protein Precursor Causes Sustained Apoptosis Signal-Regulating Kinase 1/c-Jun NH2-Terminal Kinase-Mediated Neurotoxic Signal via Dimerization

I. Nishimoto, H. Ichijo, H. Nishitoh, 2003, Journal of Pharmacology and Experimental Therapeutics.

Phosphorylation-dependent Scaffolding Role of JSAP1/JIP3 in the ASK1-JNK Signaling Pathway

Michihiko Ito, H. Ichijo, K. Yoshioka, 2002, The Journal of Biological Chemistry.

Tumor growth inhibition by arsenic trioxide (As2O3) in the orthotopic metastasis model of androgen-independent prostate cancer.

O. Ogawa, H. Ichijo, Y. Kakehi, 2001, Cancer research.

ER-resident sensor PERK is essential for mitochondrial thermogenesis in brown adipose tissue

Katsuaki Sato, S. Torii, H. Ichijo, 2020, Life Science Alliance.

Role of the unfolded protein response in the development of central nervous system

H. Nishitoh, Naoya Murao, 2017, Journal of biochemistry.

A systematic immunoprecipitation approach reinforces the concept of common conformational alterations in amyotrophic lateral sclerosis-linked SOD1 mutants

S. Tsuji, H. Ichijo, H. Nishitoh, 2015, Neurobiology of Disease.

A novel monoclonal antibody reveals a conformational alteration shared by amyotrophic lateral sclerosis‐linked SOD1 mutants

S. Tsuji, H. Ichijo, H. Nishitoh, 2012, Annals of neurology.

Endoplasmic reticulum quality control by garbage disposal

H. Nishitoh, H. Kadowaki, 2018, The FEBS journal.

Paradigm shift from ‘Compartment’ to ‘Zone’ in the understanding of organelles

H. Nishitoh, 2018, Journal of biochemistry.

OP-JBIO180111 97..100

H. Nishitoh, 2019 .

Involvement of ASK1-p38 pathway in the pathogenesis of diabetes triggered by pancreatic ß cell exhaustion.

Y. Ouchi, H. Ichijo, K. Takeda, 2013, Biochimica et biophysica acta.

USP14 inhibits ER-associated degradation via interaction with IRE1alpha.

H. Ichijo, K. Takeda, H. Nishitoh, 2009, Biochemical and biophysical research communications.

Monitoring Lipid Droplet Dynamics in Living Cells by Using Fluorescent Probes.

H. Kato, H. Nishitoh, M. Ishiyama, 2019, Biochemistry.

The cytoplasmic domain of Alzheimer’s amyloid- protein precursor causes sustained ASK1/JNK mediated neurotoxic signal via dimerization

I. Nishimoto, H. Ichijo, H. Nishitoh, 2003 .

Chemical chaperones ameliorate neurodegenerative disorders in Derlin-1-deficient mice via improvement of cholesterol biosynthesis

H. Nishitoh, H. Kadowaki, Takashi Sugiyama, 2022, Scientific reports.

Molecular mechanism of ER stress-induced pre-emptive quality control involving association of the translocon, Derlin-1, and HRD1

H. Nishitoh, Y. Takami, H. Kadowaki, 2018, Scientific Reports.

CHIP‐dependent termination of MEKK2 regulates temporal ERK activation required for proper hyperosmotic response

H. Shibuya, Keiji Tanaka, H. Ichijo, 2010, The EMBO journal.

SOD1 as a molecular switch for initiating the homeostatic ER stress response under zinc deficiency.

H. Ichijo, K. Takeda, H. Nishitoh, 2013, Molecular cell.

Identification of Type I and Type II Serine/Threonine Kinase Receptors for Growth/Differentiation Factor-5*

K. Miyazono, H. Ichijo, A. Yamaguchi, 1996, The Journal of Biological Chemistry.

ASK1 regulates influenza virus infection-induced apoptotic cell death.

Kazufumi Shimizu, Yasuhiro Gon, T. Horie, 2003, Biochemical and biophysical research communications.

RbAp48 is essential for viability of vertebrate cells and plays a role in chromosome stability

T. Fukagawa, H. Nishitoh, T. Nakayama, 2016, Chromosome Research.

ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats.

Kiyoshi Inoue, H. Ichijo, K. Takeda, 2002, Genes & development.

Life and Death under the ER Stress Condition

H. Nishitoh, 2004 .

Physiological Roles of ASK 1-Mediated Signal Transduction in Oxidative Stress-and Endoplasmic Reticulum Stress-Induced Apoptosis : Advanced Findings from ASK 1 Knockout Mice

H. Ichijo, K. Takeda, H. Nishitoh, 2003 .

Physiological roles of ASK1-mediated signal transduction in oxidative stress- and endoplasmic reticulum stress-induced apoptosis: advanced findings from ASK1 knockout mice.

H. Ichijo, K. Takeda, H. Nishitoh, 2002, Antioxidants & redox signaling.

Apoptosis signaling kinases: from stress response to health outcomes.

H. Ichijo, K. Takeda, H. Nishitoh, 2011, Antioxidants & redox signaling.

ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis

Hiromi Nakamura, S. Kōzuma, Y. Taketani, 2009, The EMBO journal.

The Src/c-Abl pathway is a potential therapeutic target in amyotrophic lateral sclerosis

Ryuji Kaji, Keiko Imamura, Shinya Yamanaka, 2017, Science Translational Medicine.

Histone acetyltransferase PCAF is involved in transactivation of Bcl-6 and Pax5 genes in immature B cells.

H. Nishitoh, S. Imajoh-ohmi, H. Kikuchi, 2015, Biochemical and biophysical research communications.

GCN5 is essential for IRF‐4 gene expression followed by transcriptional activation of Blimp‐1 in immature B cells

H. Nishitoh, S. Imajoh-ohmi, H. Kikuchi, 2014, Journal of leukocyte biology.

Stress Responses from the Endoplasmic Reticulum in Cancer

H. Kato, H. Nishitoh, 2015, Front. Oncol..

Histone acetyltransferase p300/CBP‐associated factor is an effective suppressor of secretory immunoglobulin synthesis in immature B cells

H. Nishitoh, S. Imajoh-ohmi, H. Kikuchi, 2015, Microbiology and immunology.

Amyloid beta induces neuronal cell death through ROS-mediated ASK1 activation.

F. Urano, H. Masutani, J. Yodoi, 2005, Cell death and differentiation.

Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxidative stress

H. Ichijo, H. Nishitoh, H. Matsuura, 2001, The EMBO journal.

ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity

Kunihiro Matsumoto, H. Ichijo, S. Koyasu, 2005, Nature Immunology.

Lack of GCN5 remarkably enhances the resistance against prolonged endoplasmic reticulum stress-induced apoptosis through up-regulation of Bcl-2 gene expression.

H. Nishitoh, S. Imajoh-ohmi, H. Kikuchi, 2015, Biochemical and biophysical research communications.

Identification of a Novel Bone Morphogenetic Protein-responsive Gene That May Function as a Noncoding RNA*

K. Miyazono, H. Ichijo, K. Takeda, 1998, The Journal of Biological Chemistry.

Involvement of ASK1 in Ca2+‐induced p38 MAP kinase activation

J. Ninomiya-Tsuji, Kunihiro Matsumoto, H. Ichijo, 2004, EMBO reports.

Oxidation-triggered c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein (MAP) kinase pathways for apoptosis in human leukaemic cells stimulated by epigallocatechin-3-gallate (EGCG): a distinct pathway from those of chemically induced and receptor-mediated apoptosis.

Hong Zhang, H. Ichijo, K. Saeki, 2002, The Biochemical journal.

Identification of Important Regions in the Cytoplasmic Juxtamembrane Domain of Type I Receptor That Separate Signaling Pathways of Transforming Growth Factor-β (*)

K. Miyazono, H. Ichijo, M. Takagi, 1996, The Journal of Biological Chemistry.

Activation of Apoptosis Signal-Regulating Kinase 1 (ASK1) by Tumor Necrosis Factor Receptor-Associated Factor 2 Requires Prior Dissociation of the ASK1 Inhibitor Thioredoxin

Hong Liu, H. Ichijo, J. Kyriakis, 2000, Molecular and Cellular Biology.

ASK1 is essential for JNK/SAPK activation by TRAF2.

K. Miyazono, M. Rothe, H. Nakano, 1998, Molecular cell.

Roles of MAPKKK ASK1 in stress-induced cell death.

H. Ichijo, K. Takeda, H. Nishitoh, 2003, Cell structure and function.

Roles of MAPKKK ASK1 in stress-induced cell death.

H. Ichijo, K. Takeda, H. Nishitoh, 2003, Cell structure and function.

Apoptosis Signal-regulating Kinase 1 (ASK1) Induces Neuronal Differentiation and Survival of PC12 Cells*

H. Ichijo, K. Takeda, H. Nishitoh, 2000, The Journal of Biological Chemistry.

RbAp48 is essential for viability of vertebrate cells and plays a role in chromosome stability

T. Fukagawa, H. Nishitoh, T. Nakayama, 2015, Chromosome Research.

Signaling Pathways from the Endoplasmic Reticulum and Their Roles in Disease

H. Nishitoh, Hisae Kadowaki, Hideki Nishitoh, 2013, Genes.

GCN5 Protects Vertebrate Cells against UV-irradiation via Controlling Gene Expression of DNA Polymerase η*

H. Nishitoh, S. Imajoh-ohmi, H. Kikuchi, 2012, The Journal of Biological Chemistry.

Expression of DNA Polymerase UV-irradiation via Controlling Gene GCN 5 Protects Vertebrate Cells against Gene Regulation :

H. Nishitoh, S. Imajoh-ohmi, H. Kikuchi, 2012 .

Als-linked Mutant Sod1 Induces Er Stress-and Ask1-dependent Motor Neuron Death by Targeting Derlin-1 -induced Cell Death Remains Controversial. Here We Show That Sod1 Mut Specifically Interacted with Derlin-1, a Component of Endoplasmic Reticulum (er)-associated Degradation (erad) Machinery and Trig

Takanori Yokota, H. Ichijo, K. Takeda, 2022 .

[Identification of receptors for bone morphogenetic proteins].

H. Nishitoh, 1997, Kokubyo Gakkai zasshi. The Journal of the Stomatological Society, Japan.

The Expression of Fn14 via Mechanical Stress-activated JNK Contributes to Apoptosis Induction in Osteoblasts*

H. Ichijo, K. Takeda, H. Nishitoh, 2014, The Journal of Biological Chemistry.

Regulation of Angiogenesis by TGF-β Superfamily

K. Miyazono, H. Ichijo, H. Nishitoh, 1997 .

The ASK1-specific inhibitors K811 and K812 prolong survival in a mouse model of amyotrophic lateral sclerosis.

Yuki Hayashi, H. Ichijo, H. Nishitoh, 2016, Human molecular genetics.

Molecular mechanism of ER stress-induced pre-emptive quality control involving association of the translocon, Derlin-1, and HRD1

H. Nishitoh, Y. Takami, H. Kadowaki, 2018, Scientific Reports.

[Molecular mechanisms of ER stress-induced apoptosis].

H. Ichijo, H. Nishitoh, 2004, Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme.

A mouse model reveals that Mfsd2a is critical for unfolded protein response upon exposure to tunicamycin

M. Takagi, H. Moritake, H. Nishitoh, 2017, Human Cell.

Homeostatic Regulation of Seizure Susceptibility and Cognitive Function by ER Quality Controller Derlin-1 through Maintenance of Adult Neurogenesis

T. Katagiri, H. Nishitoh, K. Tanimoto, 2023, bioRxiv.

ERAD components Derlin-1 and Derlin-2 are essential for postnatal brain development and motor function

K. Mikoshiba, A. Futatsugi, T. Katagiri, 2021, iScience.

Homeostatic Regulation of Seizure Susceptibility and Cognitive Function by Derlin-1 through Maintenance of Adult Neurogenesis

T. Katagiri, H. Nishitoh, K. Tanimoto, 2023, bioRxiv.

GCN5 is involved in regulation of immunoglobulin heavy chain gene expression in immature B cells.

H. Nishitoh, H. Kikuchi, T. Nakayama, 2014, Gene.

Protein kinase Cθ gene expression is oppositely regulated by GCN5 and EBF1 in immature B cells

H. Nishitoh, H. Kikuchi, T. Nakayama, 2014, FEBS letters.

STT3B-dependent posttranslational N-glycosylation as a surveillance system for secretory protein.

M. Taura, M. Suico, T. Shuto, 2012, Molecular cell.

ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1.

H. Ichijo, K. Takeda, H. Nishitoh, 2008, Genes & development.