M. Searle

F. Gianfrancesco, T. Esposito, G. Morello, 2012, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Disruption of ubiquitin-mediated processes in diseases of the brain and bone.

M. Searle, R. Layfield, 2008, Biochemical Society transactions.

Mutant p62/SQSTM1 UBA domains linked to Paget's disease of bone differ in their abilities to function as stabilization signals

S. Ralston, M. Searle, R. Layfield, 2010, FEBS letters.

Anthracycline antibiotic arugomycin binds in both grooves of the DNA helix simultaneously: an NMR and molecular modelling study.

W. Denny, M. Searle, L. P. Wakelin, 1991, Nucleic acids research.

Loss of Ubiquitin Binding Is a Unifying Mechanism by Which Mutations of SQSTM1 Cause Paget’s Disease of Bone

S. Ralston, M. Searle, R. Layfield, 2006, Calcified Tissue International.

An ALS-associated variant of the autophagy receptor SQSTM1/p62 reprograms binding selectivity toward the autophagy-related hATG8 proteins

N. Oldham, D. Scott, M. Searle, 2021, The Journal of biological chemistry.

SQSTM1 mutations--bridging Paget disease of bone and ALS/FTLD.

M. Searle, R. Layfield, S. Rea, 2014, Experimental cell research.

Paget disease of bone-associated UBA domain mutations of SQSTM1 exert distinct effects on protein structure and function

F. Gianfrancesco, T. Esposito, S. Ralston, 2014, Biochimica et biophysica acta.

Impact of p62/SQSTM1 UBA domain mutations linked to Paget's disease of bone on ubiquitin recognition.

M. Searle, R. Layfield, J. Long, 2011, Biochemistry.

A sequence-based approach for prediction of CsrA/RsmA targets in bacteria with experimental validation in Pseudomonas aeruginosa

R. Kulkarni, Tao Jia, S. Heeb, 2014, Nucleic acids research.

Glycopeptide antibiotic activity and the possible role of dimerization : A model for biological signaling

Dudley H. Williams, U. Gerhard, J. Mackay, 1994 .

Asiani, Karishma R. and Williams, Huw and Bird, Louise and Jenner, Matthew and Searle, Mark S. and Hobman, Jon L. and Scott, David J. and Soultanas, Panos (2016)

J. Hobman, M. Searle, D. J. Scott, 2017 .

Novel UBA Domain Mutations of SQSTM1 in Paget's Disease of Bone: Genotype Phenotype Correlation, Functional Analysis, and Structural Consequences

L. Hocking, S. Ralston, G. Lucas, 2004, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Characterization of a Non‐UBA Domain Missense Mutation of Sequestosome 1 (SQSTM1) in Paget's Disease of Bone

M. Brandi, M. Searle, R. Layfield, 2009, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

p62 mutations, ubiquitin recognition and Paget's disease of bone.

S. Ralston, M. Searle, R. Layfield, 2006, Biochemical Society transactions.

Structural and functional studies of mutations affecting the UBA domain of SQSTM1 (p62) which cause Paget's disease of bone.

L. Hocking, S. Ralston, M. Searle, 2004, Biochemical Society transactions.

Probing affinity and ubiquitin linkage selectivity of ubiquitin-binding domains using mass spectrometry.

N. Oldham, J. Strachan, M. Searle, 2012, Journal of the American Chemical Society.

Do interstrand hydrogen bonds contribute to β-hairpin peptide stability in solution? IR analysis of peptide folding in water

M. W. George, S. Griffiths-Jones, M. Searle, 2000 .

DNA replication initiation in Bacillus subtilis: structural and functional characterization of the essential DnaA–DnaD interaction

Timothy D. Craggs, H. Murray, M. Searle, 2018, bioRxiv.

Factor XII and kininogen asymmetric assembly with gC1qR/C1QBP/P32 is governed by allostery.

J. Emsley, I. Dreveny, K. McCrae, 2020, Blood.

Interaction of the antitumour antibiotic luzopeptin with the hexanucleotide duplex d(5'-GCATGC)2. One-dimensional and two-dimensional n.m.r. studies.

W. Denny, M. Searle, L. P. Wakelin, 1989, The Biochemical journal.

ALS-FTLD associated mutations of SQSTM1 impact on Keap1-Nrf2 signalling

M. Searle, R. Layfield, B. Shaw, 2016, Molecular and Cellular Neuroscience.

The S349T mutation of SQSTM1 links Keap1/Nrf2 signalling to Paget's disease of bone.

B. K. Park, C. Goldring, M. Searle, 2013, Bone.

Binding of anthracycline antibiotic nogalamycin to the site of a DNA single strand break engineered between two co-axially stacked hairpins

M. Searle, M. Colgrave, H. Williams, 2001 .

Successful Predictions of the Residual Motion of Weakly Associated Species as a Function of the Bonding between Them

Dudley H. Williams, M. Searle, J. Klein, 1996 .

Enhancement of Electrostatic Binding Through Cooperative Interactions: Enthalpy/Entropy Compensation and Peptide—Peptide Recognition

Dudley H. Williams, M. Searle, P. Groves, 1995 .

G-quadruplex ligands mediate downregulation of DUX4 expression

L. Popplewell, G. Dickson, M. Searle, 2020, Nucleic acids research.

Origin of β-Hairpin Stability in Solution: Structural and Thermodynamic Analysis of the Folding of a Model Peptide Supports Hydrophobic Stabilization in Water

M. Searle, G. Sharman, A. J. Maynard, 1998 .

A Targeted Oligonucleotide Enhancer of SMN2 Exon 7 Splicing Forms Competing Quadruplex and Protein Complexes in Functional Conditions

I. Eperon, A. Bottrill, M. Searle, 2014, Cell reports.

Structure of a drug-induced DNA T-bulge: implications for DNA frameshift mutations.

M. Searle, M. Colgrave, H. Williams, 2002, Angewandte Chemie.

Drug recognition of a DNA single strand break: nogalamycin intercalation between coaxially stacked hairpins.

M. Searle, M. Colgrave, H. Williams, 2002, European journal of biochemistry.

Synthesis of 6-arylisocytosines and their potential for hydrogen bonding interactions

M. Stevens, M. Searle, W. Lewis, 2015 .

Recognition and stabilization of quadruplex DNA by a potent new telomerase inhibitor: NMR studies of the 2:1 complex of a pentacyclic methylacridinium cation with d(TTAGGGT)4

M. Searle, E. Gavathiotis, R. Heald, 2001 .

The structure of an asymmetric dimer relevant to the mode of action of the glycopeptide antibiotics.

J. Mackay, D. Williams, M. Searle, 1994, Structure.

DNA minor groove recognition by bis-benzimidazole analogues of Hoechst 33258: insights into structure-DNA affinity relationships assessed by fluorescence titration measurements.

M. Searle, C. Bostock-Smith, 1999, Nucleic acids research.

Telomestatin: formal total synthesis and cation-mediated interaction of its seco-derivatives with G-quadruplexes.

M. Searle, C. Moody, H. Williams, 2011, Journal of the American Chemical Society.

Partitioning of free energy contributions in the estimation of binding constants : Residual motions and consequences for amide-amide hydrogen bond strengths

Dudley H. Williams, U. Gerhard, M. Searle, 1992 .

Application of a generalised enthalpy–entropy relationship to binding co-operativity and weak associations in solution

Dudley H. Williams, M. Searle, M. Westwell, 1995 .

Peptide models of protein β-sheets: design, folding and insights into stabilising weak interactions

M. Searle, 2001 .

Empirical Correlations between Thermodynamic Properties and Intermolecular Forces

D. Wales, Dudley H. Williams, M. Searle, 1995 .

Tuneable DNA-based asymmetric catalysis using a G-quadruplex supramolecular assembly.

Tom Garner, Mark Searle, M. Searle, 2010, Chemical communications.

Drug recognition and stabilisation of the parallel-stranded DNA quadruplex d(TTAGGGT)4 containing the human telomeric repeat.

M. Searle, E. Gavathiotis, R. Heald, 2003, Journal of Molecular Biology.

Electrospray ionisation mass spectrometric detection of weak non-covalent interactions in nogalamycin-DNA complexes.

M. Searle, M. Colgrave, M. Sheil, 2002, Chemical communications.

Design of histidine-Zn2+ binding sites within a β-hairpin peptide: enhancement of β-sheet stability through metal complexation

C. Chung, M. Searle, Geoffrey W. Platt, 2001 .

Design and Stability of Peptide β-sheets

M. Searle, 2008 .

ENHANCED BINDING OF A HEXACYCLIC AMIDINE ANALOGUE OF HOECHST 33258 TO THE MINOR GROOVE OF DNA : 1H NMR AND UV MELTING STUDIES WITH THE DECAMER DUPLEX D(GGTAATTACC)2

M. Searle, K. Embrey, C. Bostock-Smith, 1997 .

Sequence-specific interaction of Hoechst 33258 with the minor groove of an adenine-tract DNA duplex studied in solution by 1H NMR spectroscopy

M. S. Searle, K. J. Embrey, M. Searle, 1990, Nucleic Acids Res..

SilE is an intrinsically disordered periplasmic “molecular sponge” involved in bacterial silver resistance

J. Hobman, D. Scott, M. Searle, 2016, Molecular microbiology.

Synthesis of 6‐Arylisocytosines and Their Potential for Hydrogen Bonding Interactions.

M. Stevens, M. Searle, W. Lewis, 2016 .

DNA recognition by the anthracycline antibiotic respinomycin D: NMR structure of the intercalation complex with d(AGACGTCT)2.

M. Searle, H. Williams, A. J. Maynard, 2003, Organic & biomolecular chemistry.

Enthalpy/entropy compensation effects from cavity desolvation underpin broad ligand binding selectivity for rat odorant binding protein 3.

David J Scott, Stephen Carr, Loïc Briand, 2014, Biochemistry.

Enantiopure titanocene complexes--direct evidence for paraptosis in cancer cells.

M. Fay, T. Bradshaw, M. Searle, 2016, Metallomics : integrated biometal science.

Structure of the parallel-stranded DNA quadruplex d(TTAGGGT)4 containing the human telomeric repeat: evidence for A-tetrad formation from NMR and molecular dynamics simulations.

M. Searle, E. Gavathiotis, 2003, Organic & biomolecular chemistry.

NMR Studies of Drug—DNA interactions

M. Searle, 1993 .

Interaction of Hoechst 33258 with the minor groove of the A + T-rich DNA duplex d(GGTAATTACC)2 studied in solution by NMR spectroscopy.

D. Craik, M. Searle, K. Embrey, 1993, European journal of biochemistry.

Cooperativity in drug-DNA recognition: a molecular dynamics study.

M. Orozco, C. Laughton, M. Searle, 2001, Journal of the American Chemical Society.

Ubiquitin Recognition by the Ubiquitin-associated Domain of p62 Involves a Novel Conformational Switch*

S. Ralston, M. Searle, R. Layfield, 2008, Journal of Biological Chemistry.

The cost of conformational order: entropy changes in molecular associations

Dudley H. Williams, M. Searle, Mark S. Searle, 1992 .

The Highly Repetitive Region of the Helicobacter pylori CagY Protein Comprises Tandem Arrays of an α-Helical Repeat Module

K. Bunting, M. Searle, J. Atherton, 2008, Journal of molecular biology.

Structural insights into the targeting of mRNA GU-rich elements by the three RRMs of CELF1

J. Emsley, M. Searle, Mark S. Searle, 2013, Nucleic acids research.

Structural insights into the targeting of mRNA GU-rich elements by the three RRMs of CELF 1

J. Emsley, M. Searle, C. H. Moor, 2013 .

Sequence determinants for the tandem recognition of UGU and CUG rich RNA elements by the two N—terminal RRMs of CELF1

J. Emsley, M. Searle, A. Kondrashov, 2011, Nucleic acids research.

Rationally designed ligands as models for bacterial cell-wall recognition by vancomycin-group antibiotics

Dudley H. Williams, M. Searle, P. Groves, 1994, Proceedings / Indian Academy of Sciences.

Recognition of the cell-wall binding site of the vancomycin-group antibiotics by unnatural structural motifs: 1H NMR studies of the effects of ligand binding on antibiotic dimerisation

Dudley H. Williams, M. Searle, P. Groves, 1994 .

Structure/activity studies of the anti-MUC1 monoclonal antibody C595 and synthetic MUC1 mucin-core-related peptides and glycopeptides.

A. Murray, M. Price, M. Searle, 1999, Biospectroscopy.

Defective recognition of LC3B by mutant SQSTM1/p62 implicates impairment of autophagy as a pathogenic mechanism in ALS-FTLD

Robert Layfield, Terje Johansen, Barry Shaw, 2016, Autophagy.

Sequence specific conformation of a DNA decamer containing an adenine tract studied in solution by H-NMR spectroscopy.

M. Searle, L. P. Wakelin, L. Wakelin, 1990, Biochimica et biophysica acta.

p 62 mutations , ubiquitin recognition and Paget ’ s disease of bone

S. Ralston, M. Searle, R. Layfield, 2006 .

Prion protein fragments spanning helix 1 and both strands of beta sheet (residues 125-170) show evidence for predominantly helical propensity by CD and NMR.

R. Mayer, M. Searle, G. Sharman, 1998, Folding & design.

Dissecting the stability of a beta-hairpin peptide that folds in water: NMR and molecular dynamics analysis of the beta-turn and beta-strand contributions to folding.

S. Griffiths-Jones, M. Searle, A. J. Maynard, 1999, Journal of molecular biology.

Hoogsteen versus Watson‐Crick A‐T basepairing in DNA complexes of a new group of ‘quinomycin‐like’ antibiotics

M. Searle, G. Wickham, 1990, FEBS letters.

Dimerisation of the UBA domain of p62 inhibits ubiquitin binding and regulates NF-kappaB signalling.

M. Williamson, M. Searle, R. Layfield, 2010, Journal of molecular biology.

Trimethoprim binding to Lactobacillus casei dihydrofolate reductase: a 13C NMR study using selectively 13C-enriched trimethoprim.

J. Feeney, G. Roberts, M. Searle, 1986, Biochemistry.

Loss of Ubiquitin‐Binding Associated With Paget's Disease of Bone p62 (SQSTM1) Mutations

L. Hocking, S. Ralston, M. Searle, 2004, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Structural comparisons of complexes of methotrexate analogues with Lactobacillus casei dihydrofolate reductase by two-dimensional 1H NMR at 500 MHz.

J. Feeney, G. Roberts, M. Searle, 1987, Biochemistry.

Dihydrofolate reductase. 1H resonance assignments and coenzyme-induced conformational changes.

J. Feeney, G. Roberts, M. Searle, 1986, Journal of molecular biology.

Identification of the 1H resonances of valine and leucine residues in dihydrofolate reductase by using a combination of selective deuteration and two‐dimensional correlation spectroscopy

J. Feeney, G. Roberts, M. Searle, 1986, FEBS letters.

Engineering Enhanced Protein Stability through β‐Turn Optimization: Insights for the Design of Stable Peptide β‐Hairpin Systems

M. Searle, R. Bofill, M. Crespo, 2005 .

Insights into stabilizing weak interactions in designed peptide β-hairpins

M. Searle, 2004 .

Folding of a beta-hairpin peptide derived from the N-terminus of ubiquitin. Conformational preferences of beta-turn residues dictate non-native beta-strand interactions.

S. Griffiths-Jones, M. Searle, M. Jourdan, 2000, European journal of biochemistry.

Steady state and time-resolved IR spectroscopy of the native and unfolded states of bovine ubiquitin: protein stability and temperature-jump kinetic measurements of protein folding at low pH

S. Griffiths-Jones, I. Clark, M. Searle, 2000 .

Thermodynamics of Side Chain Internal Rotations – Effects on Protein Structure and Stability

A. Doig, Dudley H. Williams, M. Gardner, 1993 .

Bile acid interactions with rabbit ileal lipid binding protein and an engineered helixless variant reveal novel ligand binding properties of a versatile beta-clam shell protein scaffold.

N. Oldham, M. Searle, Kathryn Ball, 2007, Journal of molecular biology.

15N and 1H NMR evidence for multiple conformations of the complex of dihydrofolate reductase with its substrate, folate

J. Feeney, G. Roberts, M. Searle, 1987, FEBS letters.

Mass spectrometry insights into a tandem ubiquitin‐binding domain hybrid engineered for the selective recognition of unanchored polyubiquitin

N. Oldham, D. Tooth, A. Bottrill, 2016, Proteomics.

Structure and K+ ion-dependent stability of a parallel-stranded DNA quadruplex containing a core A-tetrad.

R. J. Grant, M. Searle, C. Gallagher, 2004, Organic & biomolecular chemistry.

Folding topology of a bimolecular DNA quadruplex containing a stable mini-hairpin motif within the diagonal loop.

M. Searle, H. Williams, Thomas P. Garner, 2008, Journal of molecular biology.

Structure, dynamics and hydration of the nogalamycin-d(ATGCAT)2Complex determined by NMR and molecular dynamics simulations in solution.

M. Searle, H. Williams, 1999, Journal of molecular biology.

Structure of the nogalamycin–d(ATGCAT)2 complex in solution: DNA recognition at an isolated TpG site

M. Searle, H. Williams, 1998 .

Structural basis of the leukocyte integrin Mac-1 I-domain interactions with the platelet glycoprotein Ib.

J. Emsley, M. Saleem, M. Searle, 2019, Blood advances.

Molecular recognition between a new pentacyclic acridinium salt and DNA sequences investigated by optical spectroscopic techniques, proton nuclear magnetic resonance spectroscopy, and molecular modeling.

C. Laughton, M. Stevens, M. Searle, 1999, Biochemistry.

Overview of Protein Folding Mechanisms: Experimental and Theoretical Approaches to Probing Energy Landscapes

M. Searle, Mark S. Searle, Elizabeth R. Morris, 2012, Current protocols in protein science.

Aromatic residues engineered into the beta-turn nucleation site of ubiquitin lead to a complex folding landscape, non-native side-chain interactions, and kinetic traps.

M. Searle, H. Williams, E. R. Simpson, 2008, Biochemistry.

Sequential barriers and an obligatory metastable intermediate define the apparent two-state folding pathway of the ubiquitin-like PB1 domain of NBR1.

M. Searle, Ping-Yen Chen, J. Long, 2008, Journal of molecular biology.

Engineering stabilising beta-sheet interactions into a conformationally flexible region of the folding transition state of ubiquitin.

M. Searle, R. Bofill, 2005, Journal of molecular biology.

Energetics of Weak Interactions in a β-hairpin Peptide: Electrostatic and Hydrophobic Contributions to Stability from Lysine Salt Bridges

S. Griffiths-Jones, M. Searle, Henry Skinner-Smith, 1999 .

Population of on-pathway intermediates in the folding of ubiquitin.

M. Searle, M. Crespo, E. R. Simpson, 2006, Journal of molecular biology.

Extending the folding nucleus of ubiquitin with an independently folding beta-hairpin finger: hurdles to rapid folding arising from the stabilisation of local interactions.

M. Searle, Geoffrey W. Platt, R. Bofill, 2005, Journal of molecular biology.

Context-dependent effects of proline residues on the stability and folding pathway of ubiquitin.

M. Searle, Geoffrey W. Platt, R. Bofill, 2004, European journal of biochemistry.

Structure, folding, and energetics of cooperative interactions between the beta-strands of a de novo sesigned three-stranded antiparallel beta-sheet peptide

M. Searle, Mark S. Searle, Samuel R. Griffiths-Jones and, 2000 .

Cooperative Interaction between the Three Strands of a Designed Antiparallel β-Sheet

M. Searle, Mark S. Searle, Gary J. Sharman and, 1998 .

NMR structural analysis of a β-hairpin peptide designed forDNA binding

M. Searle, A. J. Maynard, 1997 .

Native-like beta-hairpin structure in an isolated fragment from ferredoxin: NMR and CD studies of solvent effects on the N-terminal 20 residues.

D. Williams, M. Searle, R. Zerella, 1996, Protein engineering.

A short linear peptide derived from the N-terminal sequence of ubiquitin folds into a water-stable non-native β-hairpin

Dudley H. Williams, M. Searle, L. Packman, 1995, Nature Structural Biology.

Occurrence of a quadruplex motif in a unique insert within exon C of the bovine estrogen receptor alpha gene (ESR1).

C. Hodgman, M. Searle, K. Derecka, 2010, Biochemistry.

Sequence-dependent variation in DNA minor groove width dictates orientational preference of Hoechst 33258 in A-tract recognition: solution NMR structure of the 2:1 complex with d(CTTTTGCAAAAG)(2).

M. Searle, E. Gavathiotis, G. Sharman, 2000, Nucleic acids research.

Probing the interaction of Hoechst 33258 with an A–T rich oligonucleotide duplex using 1H NMR spectroscopy

D. Craik, M. Searle, K. Embrey, 1991 .

A Fluorescence Resonance Energy Transfer Assay For Monitoring α- Synclein Aggregation in a Caenorhabditis Elegans Model For Parkinson's Disease.

K. Morgan, D. Brady, A. Nazir, 2015, CNS & neurological disorders drug targets.

Mechanism of ligand-induced folding of a natively unfolded helixless variant of rabbit I-BABP.

M. Searle, V. Thurston, Anita M. Rea, 2009, Biochemistry.

Structural Rearrangement in an RsmA/CsrA Ortholog of Pseudomonas aeruginosa Creates a Dimeric RNA-Binding Protein, RsmN

Chan Li, R. Kulkarni, J. Emsley, 2013, Structure.

The combined use of selective deuteration and double resonance experiments in assigning the 1H resonances of valine and tyrosine residues of dihydrofolate reductase

J. Feeney, G. Roberts, M. Searle, 1984, FEBS letters.

Repression of translation of human estrogen receptor alpha by G-quadruplex formation.

C. Hodgman, M. Searle, K. Derecka, 2009, Biochemistry.

Probing Protein-RNA Interactions Through Spin-Labelling and Paramagnetic Relaxation Enhancements

M. Searle, J. Edwards, 2018 .

On and off-target effects of telomere uncapping G-quadruplex selective ligands based on pentacyclic acridinium salts

C. Leonetti, M. Porru, Rupesh K. Nanjunda, 2013, Journal of experimental & clinical cancer research : CR.

Drug-induced stabilisation of a mismatched C-T base pair in a DNA hairpin.

M. Searle, C. Gallagher, 2003, Chemical communications.

Evidence for β-sheet conformation in vesicle-bound peptides derived from the transmembrane bacterial flagellar motor protein MotB from Rhodobacter sphaeroides

R. Sockett, M. Searle, G. Sharman, 2000 .

Structure and folding dynamics of a DNA hairpin with a stabilising d(GNA) trinucleotide loop: influence of base pair mis-matches and point mutations on conformational equilibria.

M. Searle, H. Williams, Graham D. Balkwill, 2007, Organic & biomolecular chemistry.

Enthalpic (electrostatic) contribution to the chelate effect: a correlation between ligand binding constant and a specific hydrogen bond strength in complexes of glycopeptide antibiotics with cell wall analogues

Dudley H. Williams, M. Searle, D. Beauregard, 1996 .

Expression of electrostatic binding cooperativity in the recognition of cell-wall peptide analogues by vancomycin group antibiotics

Dudley H. Williams, M. Searle, P. Groves, 1994 .

Relationships between structure and activity based on a partitioning of free energy contributions in the estimation of binding constants

Dudley H. Williams, M. Searle, 1993 .

Rational design and binding of modified cell-wall peptides to vancomycin-group antibiotics : Factorising free energy contributions to binding

Dudley H. Williams, U. Gerhard, M. Searle, 1993 .

Structural insights into specificity and diversity in mechanisms of ubiquitin recognition by ubiquitin-binding domains.

J. Strachan, M. Searle, R. Layfield, 2012, Biochemical Society transactions.

Induced fit DNA recognition by a minor groove binding analogue of Hoechst 33258: fluctuations in DNA A tract structure investigated by NMR and molecular dynamics simulations.

C. Laughton, M. Searle, S. Harris, 2001, Nucleic acids research.

Insights into the molecular composition of endogenous unanchored polyubiquitin chains.

N. Oldham, D. Tooth, J. Strachan, 2012, Journal of proteome research.

Independent interactions of ubiquitin-binding domains in a ubiquitin-mediated ternary complex.

J. Strachan, M. Searle, R. Layfield, 2011, Biochemistry.

Dimerisation of the UBA domain of p62 inhibits ubiquitin binding and regulates NF-kappaB signalling.

M. Williamson, M. Searle, R. Layfield, 2010, Journal of molecular biology.

Characterization of a Non‐UBA Domain Missense Mutation of Sequestosome 1 (SQSTM1) in Paget's Disease of Bone

M. Brandi, M. Searle, R. Layfield, 2009, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Disruption of ubiquitin-mediated processes in diseases of the brain and bone.

M. Searle, R. Layfield, 2008, Biochemical Society transactions.

Dynamics of trimethoprim bound to dihydrofolate reductase.

J. Feeney, G. Roberts, M. Forster, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Probing affinity and ubiquitin linkage selectivity of ubiquitin-binding domains using mass spectrometry.

N. Oldham, J. Strachan, M. Searle, 2012, Journal of the American Chemical Society.

Coupling ligand recognition to protein folding in an engineered variant of rabbit ileal lipid binding protein.

M. Searle, N. R. Thomas, Jill K Meldrum, 2006, Chemical communications.

Method for the Purification of Endogenous Unanchored Polyubiquitin Chains.

N. Oldham, D. Tooth, D. Scott, 2016, Methods in molecular biology.

The ‘n’ effect in molecular recognition

Dudley H. Williams, M. Searle, M. Westwell, 1996, Journal of molecular recognition : JMR.

Overview of Protein Folding Mechanisms: Experimental and Theoretical Approaches to Probing Energy Landscapes

M. Searle, E. R. Morris, 2012, Current protocols in protein science.

Peptide Models of Protein β-Sheets: Design, Folding and Insights into Stabilizing Weak Interactions

M. Searle, 2001 .

Tuneable DNA-based asymmetric catalysis using a G-quadruplex supramolecular assembly.

M. Searle, J. Moses, Dougal J. Ritson, 2010, Chemical Communications.