K. Nath

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Sickle cell disease: renal manifestations and mechanisms

R. Hebbel, K. Nath, 2015, Nature Reviews Nephrology.

Role of ammonia in tubulointerstitial injury.

T. Hostetter, K. Nath, E. C. Clark, 1990, Mineral and electrolyte metabolism.

Resident dendritic cells are the predominant TNF-secreting cell in early renal ischemia-reperfusion injury.

K. Nath, M. Griffin, X. Dong, 2007, Kidney international.

Differentiating Primary, Genetic, and Secondary FSGS in Adults: A Clinicopathologic Approach.

K. Nath, R. Glassock, F. Fervenza, 2018, Journal of the American Society of Nephrology : JASN.

Tubulointerstitial changes as a major determinant in the progression of renal damage.

K. Nath, K A Nath, 1992, American journal of kidney diseases : the official journal of the National Kidney Foundation.

The tubulointerstitium in progressive renal disease.

K. Nath, 1998, Kidney international.

Heme activates the heme oxygenase-1 gene in renal epithelial cells by stabilizing Nrf2.

J. Ingelfinger, J. Alam, K. Nath, 2003, American journal of physiology. Renal physiology.

Endothelial-cell heme uptake from heme proteins: induction of sensitization and desensitization to oxidant damage.

J. Eaton, G. Vercellotti, K. Nath, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease.

A. Alayash, Ann Smith, G. Vercellotti, 2014, Blood.

A monocyte‐TNF‐endothelial activation axis in sickle transgenic mice: Therapeutic benefit from TNF blockade

N. Mackman, M. G. O’Sullivan, G. Vercellotti, 2017, American journal of hematology.

Heme: a determinant of life and death in renal tubular epithelial cells.

G. Farrugia, J. Alam, K. Nath, 2004, American journal of physiology. Renal physiology.

Heme oxygenase-1: a provenance for cytoprotective pathways in the kidney and other tissues.

K. Nath, 2006, Kidney international.

Deficiency of heme oxygenase-1 impairs renal hemodynamics and exaggerates systemic inflammatory responses to renal ischemia.

A. Terzic, J. Grande, K. Nath, 2007, Kidney international.

Increased venous proinflammatory gene expression and intimal hyperplasia in an aorto-caval fistula model in the rat.

J. Grande, Z. Katušić, K. Nath, 2003, The American journal of pathology.

Effect of pyruvate on oxidant injury to isolated and cellular DNA.

M. Fischereder, R. Hebbel, K. Nath, 1994, Kidney international.

Increased Oxidative Stress in Experimental Renovascular Hypertension

C. Napoli, L. Lerman, R. Schwartz, 2001, Hypertension.

A major role for carbon monoxide as an endogenous hyperpolarizing factor in the gastrointestinal tract

Steven Mark Miller, C. Ferris, X. Lin, 2003, Proceedings of the National Academy of Sciences of the United States of America.

A Randomized, Controlled Trial of Rituximab in IgA Nephropathy with Proteinuria and Renal Dysfunction.

B. Rovin, B. Julian, J. Novak, 2017, Journal of the American Society of Nephrology : JASN.

Reactive oxygen species and acute renal failure.

K. Nath, S. Norby, Karl A. Nath, 2000, The American journal of medicine.

Human AKI and Heme Oxygenase-1

K. Nath, 2012 .

Mechanisms of aging-induced impairment of endothelium-dependent relaxation: role of tetrahydrobiopterin.

Leslie A. Smith, Z. Katušić, K. Nath, 2004, American journal of physiology. Heart and circulatory physiology.

Temporal analysis of signaling pathways activated in a murine model of two-kidney, one-clip hypertension.

L. Lerman, J. Platt, S. Textor, 2009, American journal of physiology. Renal physiology.

Heme oxygenase‐1 regulates the immune response to influenza virus infection and vaccination in aged mice

A. Badley, R. Kennedy, G. Poland, 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Transgenic sickle mice are markedly sensitive to renal ischemia-reperfusion injury.

J. Grande, Z. Katušić, R. Hebbel, 2005, The American journal of pathology.

Heme Oxygenase Activity as a Determinant of the Renal Hemodynamic Response to Low Dose Angiotensin II

L. Juncos, Z. Katušić, K. Nath, 2010 .

Heme oxygenase activity as a determinant of the renal hemodynamic response to low-dose ANG II.

L. Juncos, Z. Katušić, K. Nath, 2010, American journal of physiology. Regulatory, integrative and comparative physiology.

Nitric oxide synthase gene transfer as a tool to study biology of endothelial cells.

Z. Katušić, K. Nath, N. Caplice, 2003, Arteriosclerosis, thrombosis, and vascular biology.

Early and prominent alterations in hemodynamics, signaling, and gene expression following renal ischemia in sickle cell disease.

J. Grande, Z. Katušić, G. Vercellotti, 2010, American journal of physiology. Renal physiology.

Outcomes of arteriovenous fistula creation after the Fistula First Initiative.

E. Bergstralh, K. Nath, J. McCarthy, 2011, Clinical journal of the American Society of Nephrology : CJASN.

Glomerular inflammation induces resistance to tubular injury in the rat. A novel form of acquired, heme oxygenase-dependent resistance to renal injury.

J. Alam, T. Shanley, K. Johnson, 1996, The Journal of clinical investigation.

Platelets, antiplatelet therapy, and diabetic nephropathy.

K. Nath, 1988, Mayo Clinic proceedings.

Pathophysiology of Chronic Kidney Disease Progression: Organ and Cellular Considerations

K. Nath, A. Agarwal, 2020 .

Pathophysiology of Progression

K. Nath, A. Agarwal, 2015 .

In Remembrance of Dr. Jared James Grantham, JASN's Founding Editor-in-Chief.

K. Nath, Bonnie O’Brien, 2017, Journal of the American Society of Nephrology : JASN.

Managing the Hypoactive Sexual Desire Disorder in Women.

V. Garovic, K. Nath, Amy W. Williams, 2018, Mayo Clinic proceedings.

Affirming the Mission of Mayo Clinic Proceedings.

K. Nath, 2017, Mayo Clinic proceedings.

kidney injury Age sensitizes the kidney to heme protein-induced acute

G. Farrugia, J. Grande, Z. Katušić, 2013 .

Age sensitizes the kidney to heme protein-induced acute kidney injury.

G. Farrugia, J. Grande, Z. Katušić, 2013, American journal of physiology. Renal physiology.

KLF11 deficiency enhances chemokine generation and fibrosis in murine unilateral ureteral obstruction

J. Grande, V. Garovic, K. Nath, 2022, PloS one.

Tumor cell heme uptake induces ferritin synthesis resulting in altered oxidant sensitivity: possible role in chemotherapy efficacy.

G. Vercellotti, K. Nath, J. Čermák, 1993, Cancer research.

H-ferritin ferroxidase induces cytoprotective pathways and inhibits microvascular stasis in transgenic sickle mice

C. Steer, G. Vercellotti, R. Hebbel, 2014, Front. Pharmacol..

kidney-heart connection cardiac apoptosis, fibrosis, and diastolic dysfunction: a Experimental mild renal insufficiency mediates early

J. Korinek, M. Redfield, K. Nath, 2012 .

Experimental mild renal insufficiency mediates early cardiac apoptosis, fibrosis, and diastolic dysfunction: a kidney-heart connection.

J. Korinek, M. Redfield, K. Nath, 2012, American journal of physiology. Regulatory, integrative and comparative physiology.

A Proposal for a Serology-Based Approach to Membranous Nephropathy.

K. Nath, R. Glassock, F. Fervenza, 2017, Journal of the American Society of Nephrology : JASN.

Disease Progression and End-Stage Renal Disease in Diverse Glomerulopathies.

K. Nath, F. Fervenza, 2018, Mayo Clinic proceedings.

Acquired resistance to acute oxidative stress. Possible role of heme oxygenase and ferritin.

J. Alam, G. Vercellotti, K. Nath, 1995, Laboratory investigation; a journal of technical methods and pathology.

ß-Catenin is markedly induced in a murine model of an arteriovenous fistula: the effect of metalloproteinase inhibition.

J. Grande, Z. Katušić, K. Nath, 2010, American journal of physiology. Renal physiology.

MCP-1 contributes to arteriovenous fistula failure.

J. Grande, Z. Katušić, K. Nath, 2011, Journal of the American Society of Nephrology : JASN.

Characterization of a model of an arteriovenous fistula in the rat: the effect of L-NAME.

J. Grande, Z. Katušić, K. Nath, 2010, The American journal of pathology.

Neoangiogenesis and the presence of progenitor cells in the venous limb of an arteriovenous fistula in the rat.

J. Grande, Z. Katušić, K. Nath, 2007, American journal of physiology. Renal physiology.

Increased production of superoxide anion contributes to dysfunction of the arteriovenous fistula.

M. Tsapenko, J. Grande, L. d’Uscio, 2012, American journal of physiology. Renal physiology.

Pathophysiology ofChronicTubulo-Interstit ial DiseaseinRats Interactions ofDietary AcidLoad,Ammonia,andComplementComponentC3

K. Nath, M. Hostetter, H. Hostetter, 1985 .

Hydrogen peroxide-induced renal injury. A protective role for pyruvate in vitro and in vivo.

K. Nath, E. C. Clark, A. Salahudeen, 1991, The Journal of clinical investigation.

Redox regulation of renal DNA synthesis, transforming growth factor-beta1 and collagen gene expression.

J. Grande, K. Nath, A. Croatt, 1998, Kidney international.

Endothelial cell heme oxygenase and ferritin induction by heme proteins: a possible mechanism limiting shock damage.

G. Vercellotti, K. Nath, H. Jacob, 1992, Transactions of the Association of American Physicians.

Long-term cardiovascular changes following creation of arteriovenous fistula in patients with end stage renal disease

V. Melenovský, M. Obokata, B. Borlaug, 2017, European heart journal.

Internucleosomal cleavage of DNA as the sole criterion for apoptosis may be artifactual.

R. Hebbel, K. Nath, H. Enright, 1994, The Journal of laboratory and clinical medicine.

The Perfusion Paradox and Vascular Instability in Sickle Cell Disease

M. Gladwin, Z. Katušić, K. Nath, 2004, Microcirculation.

vaso-occlusion in murine sickle cell disease Heme triggers TLR4 signaling leading to endothelial cell activation and

A. Alayash, G. Vercellotti, R. Hebbel, 2014 .

Anomalous renal effects of tin protoporphyrin in a murine model of sickle cell disease.

L. Juncos, J. Grande, Z. Katušić, 2006, The American journal of pathology.

Oxidative stress and induction of heme oxygenase-1 in the kidney in sickle cell disease.

J. Grande, Z. Katušić, R. Hebbel, 2001, The American journal of pathology.

Cellular overexpression of heme oxygenase-1 up-regulates p21 and confers resistance to apoptosis.

J. Alam, K. Nath, A. Croatt, 2001, Kidney international.

Reactive Oxygen Species and Renal Injury

K. Nath, 1990 .

Ccl2 deficiency protects against chronic renal injury in murine renovascular hypertension

L. Lerman, J. Grande, V. Garovic, 2018, Scientific Reports.

Cardiovascular phenotype in Smad3 deficient mice with renovascular hypertension

F. Gao, J. Grande, K. Nath, 2017, PloS one.

Development of renal atrophy in murine 2 kidney 1 clip hypertension is strain independent.

L. Lerman, S. Textor, J. Grande, 2016, Research in veterinary science.

alpha-Ketoacids scavenge H2O2 in vitro and in vivo and reduce menadione-induced DNA injury and cytotoxicity.

R. Hebbel, K. Nath, A. Croatt, 1995, The American journal of physiology.

Heart failure increases protein expression and enzymatic activity of heme oxygenase-1 in the lung.

Z. Katušić, K. Nath, A. Croatt, 2004, Cardiovascular research.

Models of Human AKI: Resemblance, Reproducibility, and Return on Investment.

K. Nath, 2015, Journal of the American Society of Nephrology : JASN.

Effects of cyclosporine on the renin-angiotensin-aldosterone system and potassium excretion in renal transplant recipients.

J. Najarian, D. Sutherland, K. Nath, 1985, Archives of internal medicine.

Cyclophilins A and B oppositely regulate renal tubular epithelial cell phenotype

Justin H. Gundelach, Vanesa Fernández-Majada, R. Bram, 2020, Journal of molecular cell biology.

Hemolysis and acute kidney failure.

Q. Qian, K. Nath, S. Sethi, 2010, American journal of kidney diseases : the official journal of the National Kidney Foundation.

Induction and Functional Significance of the Heme Oxygenase System in Pathologic Shear 1 Stress in Vivo 2 3 Running Title : Vasoprotective Effects of the HO System

Matthew L. Hillestad, G. Farrugia, J. Grande, 2015 .

Induction and functional significance of the heme oxygenase system in pathological shear stress in vivo.

Matthew L. Hillestad, G. Farrugia, J. Grande, 2015, American journal of physiology. Heart and circulatory physiology.

Induction of heme oxygenase-1 is a beneficial response in a murine model of venous thrombosis.

J. Grande, Z. Katušić, K. Nath, 2008, The American journal of pathology.

Endothelial Progenitor Cells Stimulate Cerebrovascular Production of Prostacyclin By Paracrine Activation of Cyclooxygenase-2

Leslie A. Smith, Z. Katušić, T. He, 2007, Circulation research.

Temporal induction of clusterin in cisplatin nephrotoxicity.

K. Nath, A. Agarwal, J. Manivel, 1997, Journal of the American Society of Nephrology : JASN.

Bcl-xL rescues WEHI 231 B lymphocytes from oxidant-mediated death following diverse apoptotic stimuli.

T. Behrens, T. Lebien, D. Mueller, 1995, Journal of immunology.

Induction of clusterin in acute and chronic oxidative renal disease in the rat and its dissociation from cell injury.

T. Hostetter, K. Nath, J. Manivel, 1994, Laboratory investigation; a journal of technical methods and pathology.

Heme Oxygenase in Biology and Medicine

J. Alam, N. Abraham, K. Nath, 2002, Springer US.

Renal tubular epithelial cells mimic endothelial cells upon exposure to oxidized LDL.

G. Vercellotti, K. Nath, A. Agarwal, 1996, The American journal of physiology.

Interleukin-1 accounts for intrarenal Th17 cell activation during ureteral obstruction.

K. Mills, K. Nath, Michelle M. Duffy, 2012, Kidney international.

Dietary deficiency of antioxidants exacerbates ischemic injury in the rat kidney.

K. Nath, M. Paller, 1990, Kidney international.

Endothelial cell heme oxygenase and ferritin induction in rat lung by hemoglobin in vivo.

G. Vercellotti, K. Nath, H. Jacob, 1995, The American journal of physiology.

A promising approach for treatment of tumor-induced bone diseases: utilizing bisphosphonate derivatives of nucleoside antimetabolites.

J. Ingle, D. Dingli, T. Yoneda, 2010, Bone.

Antigen presentation by dendritic cells in renal lymph nodes is linked to systemic and local injury to the kidney.

K. Nath, M. Griffin, S. Swaminathan, 2005, Kidney international.

In the Limelight: December 2021.

K. Nath, 2021, Mayo Clinic proceedings.

Expression of ACE2 in the Intact and Acutely Injured Kidney

J. Grande, V. Garovic, K. Nath, 2021, Kidney360.

Heme oxygenase-1: a redoubtable response that limits reperfusion injury in the transplanted adipose liver.

K. Nath, 1999, The Journal of clinical investigation.

Vitamin E prevents renal dysfunction induced by experimental chronic bile duct ligation.

L. Juncos, J. C. Romero, K. Nath, 2003, Kidney international.

Introduction to Thematic Reviews on Aging and Geriatric Medicine.

R. Pignolo, K. Nath, 2020, Mayo Clinic proceedings.

IL-10-deficiency unmasks unique immune system defects and reveals differential regulation of organ-specific autoimmunity in non-obese diabetic mice.

Y. Kudva, K. Nath, E. Marietta, 2006, Cytokine.

Renal response to repetitive exposure to heme proteins: chronic injury induced by an acute insult.

J. Grande, K. Nath, A. Croatt, 2000, Kidney international.

Regional and systemic hemodynamic responses following the creation of a murine arteriovenous fistula.

A. Terzic, J. Grande, Z. Katušić, 2011, American journal of physiology. Renal physiology.

Renal hemodynamic, inflammatory, and apoptotic responses to lipopolysaccharide in HO-1-/- mice.

J. Alam, J. Grande, A. Badley, 2007, The American journal of pathology.

MCP-1 is up-regulated in unstressed and stressed HO-1 knockout mice: Pathophysiologic correlates.

G. Bren, J. Grande, A. Badley, 2005, Kidney international.

Mechanisms underlying induction of heme oxygenase-1 by nitric oxide in renal tubular epithelial cells.

K. Nath, A. Croatt, M. Liang, 2000, American journal of physiology. Renal physiology.

Mechanisms of vascular instability in a transgenic mouse model of sickle cell disease.

Leslie A. Smith, L. Smith, Z. Katušić, 2000, American journal of physiology. Regulatory, integrative and comparative physiology.

Redox Signaling Is an Early Event in the Pathogenesis of Renovascular Hypertension

L. Lerman, J. Grande, K. Nath, 2013, International journal of molecular sciences.

The hyperbilirubinemic Gunn rat is resistant to the pressor effects of angiotensin II.

Leslie A. Smith, T. Peterson, L. d’Uscio, 2005, American journal of physiology. Renal physiology.

Induction of Heme Oxygenase-1 as a Protective Response Against Heme Protein-Induced Renal Injury

K. Nath, S. Pittock, 2002 .

Acute cholestatic liver disease protects against glycerol-induced acute renal failure in the rat.

J. Grande, K. Nath, A. Croatt, 2001, Kidney international.

Renal oxidant injury and oxidant response induced by mercury.

T. Behrens, K. Nath, A. Croatt, 1996, Kidney international.

Increased ammoniagenesis as a determinant of progressive renal injury.

T. Hostetter, K. Nath, M. Hostetter, 1991, American journal of kidney diseases : the official journal of the National Kidney Foundation.

Mechanisms of vascular dysfunction in the interleukin-10-deficient murine model of preeclampsia indicate nitric oxide dysregulation.

J. Grande, L. d’Uscio, Z. Katušić, 2020, Kidney international.

Physiological and structural responses to chronic experimental renal allograft injury.

T. Hostetter, K. Nath, S. Kren, 1994, The American journal of physiology.

Effect of proteinuria on renal interstitium: effect of products of nitrogen metabolism.

K. Nath, A. Agarwal, 1993, American journal of nephrology.

An analysis of the DOCA-salt model of hypertension in HO-1-/- mice and the Gunn rat.

L. d’Uscio, Z. Katušić, K. Nath, 2007, American journal of physiology. Heart and circulatory physiology.

Angiotensin II induces renal oxidant stress in vivo and heme oxygenase-1 in vivo and in vitro.

K. Nath, A. Croatt, E. Haugen, 2000, Kidney international.

Transplantation of Circulating Endothelial Progenitor Cells Restores Endothelial Function of Denuded Rabbit Carotid Arteries

Leslie A. Smith, Z. Katušić, T. He, 2004, Stroke.

Vasculature and kidney complications in sickle cell disease.

Z. Katušić, K. Nath, Z. Katusic, 2012, Journal of the American Society of Nephrology : JASN.

Oxygen consumption and oxidant stress in surviving nephrons.

T. Hostetter, K. Nath, A. Croatt, 1990, The American journal of physiology.

Clusterin protects against oxidative stress in vitro through aggregative and nonaggregative properties.

K. Nath, M. Rosenberg, G. Schwochau, 1998, Kidney international.

The Modulatory Role of Heme Oxygenase on Subpressor Angiotensin II-Induced Hypertension and Renal Injury

L. Juncos, D. Stec, K. Nath, 2012, International journal of hypertension.

Regulatory role of prostanoids in glomerular microcirculation of remnant nephrons.

T. Hostetter, K. Nath, D. Chmielewski, 1987, The American journal of physiology.

Genetic deficiency of Smad3 protects against murine ischemic acute kidney injury.

J. Grande, K. Nath, G. Warner, 2011, American journal of physiology. Renal physiology.

Proteinuria as a determinant of renal expression of heme oxygenase-1: studies in models of glomerular and tubular proteinuria in the rat.

J. Alam, J. Grande, J. Pedraza-Chaverri, 2006, American journal of physiology. Renal physiology.

Heme Proteins and Kidney Injury: Beyond Rhabdomyolysis

K. Nath, R. Singh, A. Croatt, 2022, Kidney360.

Heme protein-mediated renal injury: a protective role for 21-aminosteroids in vitro and in vivo.

G. Vercellotti, K. Nath, A. Croatt, 1995, Kidney international.

CD40 inhibits B cell apoptosis by upregulating bcl-xL expression and blocking oxidant accumulation.

T. Behrens, D. Mueller, R. Noelle, 1997, The American journal of physiology.

LPS-induced murine systemic inflammation is driven by parenchymal cell activation and exclusively predicted by early MCP-1 plasma levels.

Justin E. Juskewitch, J. Platt, J. Grande, 2012, The American journal of pathology.

In the Limelight: June 2020

K. Nath, 2020, Mayo Clinic Proceedings.

The murine dialysis fistula model exhibits a senescence phenotype: pathobiological mechanisms and therapeutic potential.

A. Terzic, D. O'Brien, J. Grande, 2018, American journal of physiology. Renal physiology.

Blockade of CCR2 reduces macrophage influx and development of chronic renal damage in murine renovascular hypertension.

L. Lerman, S. Textor, J. Grande, 2016, American journal of physiology. Renal physiology.

Role of cellular metabolites in progressive renal injury.

T. Hostetter, K. Nath, E. C. Clark, 1992, Kidney international. Supplement.

A Bicentennial, a Centennial, and Mayo Clinic Proceedings.

K. Nath, 2019, Mayo Clinic proceedings.

Antithrombotic Effects of Heme-Degrading and Heme-Binding Proteins.

Matthew L. Hillestad, J. Grande, G. Vercellotti, 2020, American journal of physiology. Heart and circulatory physiology.

In vivo stimulatory effect of erythropoietin on endothelial nitric oxide synthase in cerebral arteries.

Leslie A. Smith, Z. Katušić, K. Nath, 2006, American journal of physiology. Heart and circulatory physiology.

INTRANASAL EXPOSURE TO STAPHYLOCOCCAL ENTEROTOXIN B ELICITS AN ACUTE SYSTEMIC INFLAMMATORY RESPONSE

Robin Patel, H. Kita, A. Leontovich, 2006, Shock.

Functioning of an arteriovenous fistula requires heme oxygenase-2.

G. Farrugia, J. Grande, Z. Katušić, 2013, American journal of physiology. Renal physiology.

Renal upregulation of HO-1 reduces albumin-driven MCP-1 production: implications for chronic kidney disease.

J. Alam, R. Bram, G. Bren, 2007, American journal of physiology. Renal physiology.

Hyperosmolality impairs ammonia-mediated inflammation: implications for the renal medulla.

T. Hostetter, K. Nath, E. C. Clark, 1992, The American journal of physiology.

A vector-host system to fingerprint virus tropism.

Matthew L. Hillestad, K. Nath, M. Barry, 2012, Human gene therapy.

Urinary Extracellular Vesicles of Podocyte Origin and Renal Injury in Preeclampsia.

J. Lieske, J. Grande, S. Hansson, 2017, Journal of the American Society of Nephrology : JASN.

The role of oxidants in progressive renal injury.

T. Hostetter, M. Fischereder, K. Nath, 1994, Kidney international. Supplement.

Role of TLR4 signaling in the nephrotoxicity of heme and heme proteins.

J. Grande, Z. Katušić, G. Vercellotti, 2018, American journal of physiology. Renal physiology.

Genetic deficiency of heme oxygenase-1 impairs functionality and form of an arteriovenous fistula in the mouse.

J. Grande, Z. Katušić, K. Nath, 2008, Kidney international.

Provenance of the protective property of p21.

K. Nath, 2005, American journal of physiology. Renal physiology.

Early Onset Preeclampsia Is Associated With Glycocalyx Degradation and Reduced Microvascular Perfusion

W. White, V. Garovic, K. Nath, 2019, Journal of the American Heart Association.

Human AKI and heme oxygenase-1.

K. Nath, 2012, Journal of the American Society of Nephrology : JASN.

Current, Emerging, and Anticipated Therapies for Sickle Cell Disease.

S. Rajkumar, K. Nath, 2018, Mayo Clinic proceedings.

Prominent Mitochondrial Injury as an Early Event in Heme Protein-Induced Acute Kidney Injury

J. Grande, K. Nath, R. Singh, 2022, Kidney360.

Preservation of the kidney by carbon monoxide: a black swan phenomenon.

K. Nath, 2008, Kidney international.

Smooth muscle progenitor cells in vascular disease.

Z. Katušić, K. Nath, N. Caplice, 2004, Trends in cardiovascular medicine.

Renal response to repeated exposure to endotoxin: implications for acute kidney injury.

K. Nath, 2007, Kidney international.

In the Limelight: July 2020

K. Nath, 2020, Mayo Clinic Proceedings.

Ammonia-complement interaction in the pathogenesis of progressive renal injury.

T. Hostetter, K. Nath, M. Hostetter, 1989, Kidney international. Supplement.

Role of ammonia in progressive interstitial nephritis.

T. Hostetter, K. Nath, E. C. Clark, 1991, American journal of kidney diseases : the official journal of the National Kidney Foundation.

A new model of an arteriovenous fistula in chronic kidney disease in the mouse: beneficial effects of upregulated heme oxygenase-1.

Matthew L. Hillestad, J. Grande, Z. Katušić, 2016, American journal of physiology. Renal physiology.

The role of ammonia in progressive renal injury.

T. Hostetter, K. Nath, M. Hostetter, 1991, Contributions to nephrology.

In the Limelight: July 2021.

K. Nath, 2021, Mayo Clinic proceedings.

Hemoglobinuria in the Early Poststem-Cell–Transplant Period: Risk Factors and Association with Outcomes

K. Nath, S. Manohar, W. Hogan, 2021, Kidney360.

Myoglobinuric and Hemoglobinuric Acute Kidney Injury

K. Nath, N. Murali, 2009 .

Autoxidation of cysteine generates hydrogen peroxide: cytotoxicity and attenuation by pyruvate.

K. Nath, A. Salahudeen, Karl A. Nath, 1993, The American journal of physiology.

In the Limelight: April 2020.

K. Nath, 2020, Mayo Clinic proceedings.

Simvastatin Preserves Coronary Endothelial Function in Hypercholesterolemia in the Absence of Lipid Lowering

L. Lerman, D. Holmes, R. Simari, 2001, Arteriosclerosis, thrombosis, and vascular biology.

Accommodation in ABO‐Incompatible Kidney Allografts, a Novel Mechanism of Self‐Protection Against Antibody‐Mediated Injury

M. Stegall, J. Grande, K. Nath, 2003, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Pathophysiology of chronic tubulo-interstitial disease in rats. Interactions of dietary acid load, ammonia, and complement component C3.

T. Hostetter, K. Nath, M. Hostetter, 1985, The Journal of clinical investigation.

Ferritin: a cytoprotective antioxidant strategem of endothelium.

J. Eaton, F. Apple, G. Vercellotti, 1992, The Journal of biological chemistry.

Intracellular targets in heme protein-induced renal injury.

J. Grande, R. Hebbel, K. Nath, 1998, Kidney international.

The spike protein of SARS-CoV-2 induces heme oxygenase-1: Pathophysiologic implications

R. Vile, J. Grande, K. Nath, 2021, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.

TGF-β1 is an Autocrine Mediator of Renal Tubular Epithelial Cell Growth and Collagen IV Production

J. Grande, J. Kopp, K. Nath, 2002 .

A systems biology consideration of the vasculopathy of sickle cell anemia: the need for multi-modality chemo-prophylaxsis.

G. Vercellotti, R. Hebbel, K. Nath, 2009, Cardiovascular & hematological disorders drug targets.

Ccl2 deficiency protects against chronic renal injury in murine renovascular hypertension

L. Lerman, J. Grande, V. Garovic, 2018, Scientific Reports.

Identification of a Heme Activation Site on the MD-2/TLR4 Complex

Jianjun Hu, J. Trent, G. Vercellotti, 2019, Frontiers in Immunology.

Dendritic cells facilitate accumulation of IL-17 T cells in the kidney following acute renal obstruction.

K. Nath, M. Griffin, L. Bachman, 2008, Kidney international.

Internucleosomal cleavage of DNA is insufficient evidence to conclude that cell death is apoptotic.

R. Hebbel, K. Nath, H. Enright, 1994, Blood.

Heme oxygenase-1 and acute kidney injury

K. Nath, 2014, Current opinion in nephrology and hypertension.

Increased blood flow causes coordinated upregulation of arterial eNOS and biosynthesis of tetrahydrobiopterin.

T. Peterson, L. d’Uscio, K. Nath, 2006, American journal of physiology. Heart and circulatory physiology.

Severe Acute Respiratory Syndrome Coronavirus 2, COVID-19, and the Renin-Angiotensin System

M. Pfeffer, S. Kasner, B. Bozkurt, 2020, Hypertension.

Genetic deficiency of Smad3 protects the kidneys from atrophy and interstitial fibrosis in 2K1C hypertension.

L. Lerman, S. Textor, J. Grande, 2012, American journal of physiology. Renal physiology.

The indispensability of heme oxygenase-1 in protecting against acute heme protein-induced toxicity in vivo.

J. Alam, J. Grande, K. Nath, 2000, The American journal of pathology.

Induction of heme oxygenase in toxic renal injury: a protective role in cisplatin nephrotoxicity in the rat.

J. Alam, K. Nath, A. Agarwal, 1995, Kidney international.

Mayo Clinic/Renal Pathology Society Consensus Report on Pathologic Classification, Diagnosis, and Reporting of GN.

Jai Radhakrishnan, Neeraja Kambham, Sanjeev Sethi, 2016, Journal of the American Society of Nephrology : JASN.

Inhibition of p38 MAPK attenuates renal atrophy and fibrosis in a murine renal artery stenosis model.

L. Lerman, R. Simari, S. Textor, 2013, American journal of physiology. Renal physiology.

n-3 Fatty acids block TNF-α-stimulated MCP-1 expression in rat mesangial cells.

J. Grande, K. Nath, G. Warner, 2011, American journal of physiology. Renal physiology.

and HO-independent mechanisms Heme: a novel inducer of MCP-1 through HO-dependent

J. Ingelfinger, J. Alam, K. Nath, 2016 .

Heme: a novel inducer of MCP-1 through HO-dependent and HO-independent mechanisms.

J. Ingelfinger, J. Alam, K. Nath, 2003, American journal of physiology. Renal physiology.

Heme protein-induced chronic renal inflammation: suppressive effect of induced heme oxygenase-1.

J. Alam, C. Payá, J. Grande, 2001, Kidney international.

TGF-beta1 stimulates monocyte chemoattractant protein-1 expression in mesangial cells through a phosphodiesterase isoenzyme 4-dependent process.

J. Grande, K. Nath, G. Warner, 2005, American journal of physiology. Cell physiology.

Characterization of acute reversible systemic hypertension in a model of heme protein-induced renal injury.

K. Nath, A. Croatt, D. Warden, 1999, The American journal of physiology.

Downloaded from http://hyper.ahajournals.org / by guest on February 23, 2013Essential Role of Endothelial Nitric Oxide Synthase in Vascular Effects of Erythropoietin

Leslie A. Smith, L. d’Uscio, K. Nath, 2022 .

Kidney Disease Caused by Dysregulation of the Complement Alternative Pathway: An Etiologic Approach.

K. Nath, F. Fervenza, J. V. Van Praet, 2015, Journal of the American Society of Nephrology : JASN.

Renal Outcomes in Anticoagulated Patients With Atrial Fibrillation.

P. Noseworthy, B. Gersh, N. Tangri, 2017, Journal of the American College of Cardiology.

Comparative Effectiveness and Safety of Oral Anticoagulants Across Kidney Function in Patients With Atrial Fibrillation

Jonathan W. Inselman, P. Noseworthy, N. Desai, 2020, Circulation. Cardiovascular quality and outcomes.

Iodine toxicity treated with hemodialysis and continuous venovenous hemodiafiltration.

L. Juncos, K. Nath, R. Albright, 2003, American journal of kidney diseases : the official journal of the National Kidney Foundation.

Induction of heme oxygenase is a rapid, protective response in rhabdomyolysis in the rat.

G. Vercellotti, K. Nath, H. Jacob, 1992, The Journal of clinical investigation.

Cyclophilins A and B Oppositely Regulate Renal Tubular Epithelial Phenotype

Justin H. Gundelach, R. Bram, D. Batlle, 2018, bioRxiv.

Epigenetic and senescence markers indicate an accelerated ageing-like state in women with preeclamptic pregnancies

A. Milosavljevic, J. Cunningham, J. Grande, 2021, EBioMedicine.

The functional significance of induction of heme oxygenase by oxidant stress.

K. Nath, 1994, The Journal of laboratory and clinical medicine.

Receptor-mediated endocytosis is a Trojan horse in light-chain nephrotoxicity.

K. Nath, 2010, Journal of the American Society of Nephrology : JASN.

Differentiating scleroderma renal crisis from other causes of thrombotic microangiopathy in a postpartum patient

K. Nath, Muaz M. Abudiab, M. Fidler, 2012, Clinical nephrology.

A proposal for standardized grading of chronic changes in native kidney biopsy specimens.

Jai Radhakrishnan, Neeraja Kambham, Sanjeev Sethi, 2017, Kidney international.

JASN's Silver Jubilee.

W. Couser, J. Grantham, E. Neilson, 2015, Journal of the American Society of Nephrology : JASN.

Targeting lysine‐specific demethylase 1A inhibits renal epithelial–mesenchymal transition and attenuates renal fibrosis

Xiaogang Li, Chen Yu, S. Zhuang, 2021, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Reshaping the interstitium by platelet-derived growth factor. Implications for progressive renal disease.

K. Nath, 1996, The American journal of pathology.

Heme and the vasculature: an oxidative hazard that induces antioxidant defenses in the endothelium.

J. Eaton, G. Vercellotti, K. Nath, 1994, Artificial cells, blood substitutes, and immobilization biotechnology.

Role of adenosine in contrast media-induced acute renal failure in diabetes mellitus.

T. Larson, B. King, K. Nath, 2000, Mayo Clinic proceedings.

Protective Effect of Heme Oxygenase-1 Gene Transfer against Oxyhemoglobin-Induced Endothelial Dysfunction

J. Alam, K. Nath, D. Weiler, 2001, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Vascular protection by tetrahydrobiopterin: progress and therapeutic prospects.

L. d’Uscio, K. Nath, Z. Katusic, 2009, Trends in pharmacological sciences.

Effect of γ-L-glutamyl-L-DOPA on phosphate excretion

T. Berndt, K. Nath, F. Knox, 2000 .

Complement C5 inhibition as a Novel Therapeutic Approach in Severe Pre-eclampsia.

V. Garovic, K. Nath, A. Kukla, 2022, Mayo Clinic proceedings.

Recurrent hemolytic uremic syndrome in an adult renal allograft recipient: current concepts and management.

A. Matas, K. Nath, S. Mauer, 1995, Journal of the American Society of Nephrology : JASN.

Membranous Nephropathy in Syphilis is Associated with Neuron-Derived Neurotrophic Factor

M. Haas, S. Nasr, K. Nath, 2023, Journal of the American Society of Nephrology : JASN.

Induction of renal growth and injury in the intact rat kidney by dietary deficiency of antioxidants.

K. Nath, A. Salahudeen, 1990, The Journal of clinical investigation.

Induction of heme oxygenase-1 and ferritin in the kidney in warm antibody hemolytic anemia.

K. Nath, A. Croatt, S. Zeldenrust, 2008, American journal of kidney diseases : the official journal of the National Kidney Foundation.

Physiology and pathophysiology of heme: implications for kidney disease.

J. Alam, K. Nath, M. Tracz, 2007, Journal of the American Society of Nephrology : JASN.

Modulation of Mitochondrial Complex I Activity Averts Cognitive Decline in Multiple Animal Models of Familial Alzheimer's Disease

G. Bu, Y. Pang, P. Dzeja, 2015, EBioMedicine.

Heme oxygenase is not expressed as a stress protein after renal ischemia.

K. Nath, M. Paller, M. Rosenberg, 1993, The Journal of laboratory and clinical medicine.

AKI: a path forward.

P. Kimmel, B. Molitoris, T. Nickolas, 2013, American Society of Nephrology. Clinical Journal.

Control of Oxidative Stress and Inflammation in Sickle Cell Disease with the Nrf2 Activator Dimethyl Fumarate.

G. Vercellotti, K. Nath, J. Belcher, 2017, Antioxidants & redox signaling.

Gas-generating systems in acute renal allograft rejection in the rat. Co-induction of heme oxygenase and nitric oxide synthase.

A. Matas, J. Alam, K. Nath, 1996, Transplantation.

Haem, haem oxygenase and ferritin in vascular endothelial cell injury.

J. Eaton, G. Vercellotti, K. Nath, 2003, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Signaling pathways modulated by fish oil in salt-sensitive hypertension.

J. Grande, H. Keryakos, K. Nath, 2008, American journal of physiology. Renal physiology.

fibrosis in a murine renal artery stenosis model Inhibition of p38 MAPK attenuates renal atrophy and

L. Lerman, R. Simari, S. Textor, 2013 .

The transcription regulator ATF4 is a mediator of skeletal muscle aging

A. Judge, B. Rasmussen, Scott M. Ebert, 2023, GeroScience.

Vascular Access for Hemodialysis and Value-Based Purchasing for ESRD.

A. Cheung, T. Meyer, R. Mehrotra, 2017, Journal of the American Society of Nephrology : JASN.

Vasculotoxic and Proinflammatory Effects of Plasma Heme: Cell Signaling and Cytoprotective Responses

G. Vercellotti, K. Nath, J. Belcher, 2013, ISRN oxidative medicine.

Heme oxygenase: Protective gene or Trojan horse

J. Platt, K. Nath, 1998, Nature Medicine.

Transitions and New Beginnings at Mayo Clinic Proceedings.

K. Nath, 2018, Mayo Clinic proceedings.

Haptoglobin and hemopexin inhibit vaso-occlusion and inflammation in murine sickle cell disease: Role of heme oxygenase-1 induction

S. Miescher, C. Steer, G. Vercellotti, 2018, PloS one.

Renal Functional Decline in Sickle Cell Disease and Trait.

G. Vercellotti, K. Nath, 2020, Journal of the American Society of Nephrology : JASN.

Proapoptotic, Antimigratory, Antiproliferative, and Antiangiogenic Effects of Commercial C-Reactive Protein on Various Human Endothelial Cell Types In Vitro: Implications of Contaminating Presence of Sodium Azide in Commercial Preparation

Arjun Deb, K. Nath, J. Mcconnell, 2005, Circulation research.

Heme Oxygenase-2 Protects Against Ischemic Acute Kidney Injury: The Influence of Age and Sex.

G. Farrugia, J. Grande, G. Vercellotti, 2019, American journal of physiology. Renal physiology.

Functional adaptation and remodeling of pulmonary artery in flow-induced pulmonary hypertension.

T. Peterson, K. Nath, A. Croatt, 2005, American journal of physiology. Heart and circulatory physiology.

The role of Sirt1 in renal rejuvenation and resistance to stress.

K. Nath, 2010, The Journal of clinical investigation.

Corrigendum to “Modulation of mitochondrial complex I activity averts cognitive decline in multiple animal models of familial Alzheimer's disease” [EBioMedicine 2 (2015) 294–305]

G. Bu, Y. Pang, P. Dzeja, 2019, EBioMedicine.

Endothelin-A Receptor Antagonism Retards the Progression of Murine Sickle Cell Nephropathy.

K. Nath, Z. Katusic, 2017, Journal of the American Society of Nephrology : JASN.

Introduction

G. Farrugia, K. Nath, E. Berbari, 2003, Mayo Clinic Proceedings.

The Involvement of Oxidative Stress in the Progression of Renal Injury

K. Nath, E. Haugen, 1999, Blood Purification.

Transition of Editor-in-Chief Duties at Mayo Clinic Proceedings.

K. Nath, W. Lanier, 2017, Mayo Clinic proceedings.

In the Limelight: October 2022.

K. Nath, 2022, Mayo Clinic proceedings.

In the Limelight: May 2020.

K. Nath, 2020, Mayo Clinic proceedings.

Hydrogen peroxide downregulates IL-1-driven mesangial iNOS activity: implications for glomerulonephritis.

E. Jaimes, L. Raij, K. Nath, 1997, The American journal of physiology.

Predicting the Functionality and Form of a Dialysis Fistula.

K. Nath, Z. Katusic, 2016, Journal of the American Society of Nephrology : JASN.

Dialysis Vascular Access Intervention and the Search for Biomarkers.

K. Nath, 2016, Journal of the American Society of Nephrology : JASN.

Dietary protein restriction in established renal injury in the rat. Selective role of glomerular capillary pressure in progressive glomerular dysfunction.

T. Hostetter, K. Nath, S. Kren, 1986, The Journal of clinical investigation.

In the Limelight: November 2020

K. Nath, 2020, Mayo Clinic Proceedings.

Interaction of complement and clusterin in renal injury.

T. Hostetter, K. Nath, J. Manivel, 1992, Journal of the American Society of Nephrology : JASN.

5715Anticoagulant use and associated outcomes in patients with atrial fibrillation and advanced kidney disease

P. Noseworthy, N. Tangri, N. Shah, 2017 .

Radical thoughts about kidneys.

K. Nath, M. Paller, 1991, The Journal of laboratory and clinical medicine.

Therapeutic strategies in the prevention of acute renal failure.

W. Trick, M. Fischereder, K. Nath, 1994, Seminars in nephrology.

Does the Primacy of the Fistula Still Prevail in an Aging Hemodialysis Population?

K. Nath, 2023, Journal of the American Society of Nephrology : JASN.

Proprotein Convertase Subtilisin/Kexin Type 6 (PCSK6) is a likely antigenic target in membranous nephropathy and nonsteroidal anti-inflammatory drug use.

Aaron J. Storey, S. Nasr, T. Caza, 2023, Kidney international.

Low-Dose Angiotensin II Enhances Pressor Responses Without Causing Sustained Hypertension

Laura I. Pelaez, L. Juncos, J. C. Romero, 2003, Hypertension.

CKD Due to a Novel Mitochondrial DNA Mutation: A Case Report.

M. Irazabal, S. Nasr, K. Nath, 2019, American journal of kidney diseases : the official journal of the National Kidney Foundation.

Role of prostaglandins in experimental renal disease.

T. Hostetter, K. Nath, 1989, Contributions to nephrology.

De novo focal glomerulosclerosis after kidney transplantation.

B. Burke, K. Nath, M. Rosenberg, 1988, The American journal of medicine.

Genetic deficiency of Smad 3 protects the kidneys from atrophy and interstitial fibrosis in 2 K 1 C hypertension

L. Lerman, S. Textor, J. Grande, 2012 .

Endogenous Superantigens Shape Response to Exogenous Superantigens

K. Nath, G. Rajagopalan, M. Sen, 2005, Clinical Diagnostic Laboratory Immunology.

In the Limelight: March 2021

K. Nath, 2021, Mayo Clinic proceedings.

Introduction

G. Farrugia, K. Nath, E. Berbari, 2020, Mayo Clinic Proceedings.

In the Limelight: May 2021

K. Nath, 2021, Mayo Clinic Proceedings.

In the Limelight: January 2021.

K. Nath, 2021, Mayo Clinic proceedings.

Nitric Oxide Synthase Gene Transfer as a Tool to Study Biology of Endothelial Cells

K. Nath, N. Caplice, Z. Katusic, 2003 .

JASN312Editorial 233..240

G. Vercellotti, K. Nath, 2020 .

Temporal analysis of signaling pathways activated in a murine model of two-kidney, one-clip hypertension.

L. Lerman, J. Platt, S. Textor, 2009, American journal of physiology. Renal physiology.

Challenges in Developing New Therapies for Vascular Access Dysfunction.

K. Nath, M. Allon, 2017, American Society of Nephrology. Clinical Journal.

The role of renal research in demonstrating the protective properties of heme oxygenase-1.

K. Nath, 2013, Kidney international.

AKI: a path forward.

P. Kimmel, B. Molitoris, T. Nickolas, 2013, Clinical journal of the American Society of Nephrology : CJASN.

In the Limelight: October 2021.

K. Nath, 2021, Mayo Clinic proceedings.

In the Limelight: October 2020

K. Nath, 2020, Mayo Clinic Proceedings.

The COVID-19 Pandemic and Mayo Clinic Proceedings

K. Nath, 2020, Mayo Clinic Proceedings.

In the Limelight: July 2022.

K. Nath, 2022, Mayo Clinic proceedings.

Heme oxygenase activity as a determinant of the renal hemodynamic response to low-dose ANG II.

L. Juncos, K. Nath, Melissa C Hernandez, 2010, American journal of physiology. Regulatory, integrative and comparative physiology.