A. Kellett

M. Devereux, Z. Molphy, A. Kellett, 2022, Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry.

Potent oxidative DNA cleavage by the di-copper cytotoxin: [Cu2(μ-terephthalate)(1,10-phen)4]2+.

N. Barron, M. Devereux, V. McKee, 2012, Chemical communications.

Protein engineering with artificial chemical nucleases.

V. McKee, A. Kellett, P. Leonard, 2015, Chemical communications.

In-vivo evaluation of the response of Galleria mellonella larvae to novel copper(II) phenanthroline-phenazine complexes.

M. Devereux, Z. Molphy, A. Kellett, 2018, Journal of inorganic biochemistry.

Anti-Pseudomonas aeruginosa activity of 1,10-phenanthroline-based drugs against both planktonic- and biofilm-growing cells.

M. Devereux, A. Kellett, A. L. Santos, 2016, The Journal of antimicrobial chemotherapy.

Synthesis, self-assembly, bacterial and fungal toxicity, and preliminary biodegradation studies of a series ofl-phenylalanine-derived surface-active ionic liquids

A. Kellett, L. Pérez, K. Kümmerer, 2019, Green Chemistry.

Copper(II) complexes of salicylic acid combining superoxide dismutase mimetic properties with DNA binding and cleaving capabilities display promising chemotherapeutic potential with fast acting in vitro cytotoxicity against cisplatin sensitive and resistant cancer cell lines.

M. Devereux, S. McClean, A. Kellett, 2012, Journal of medicinal chemistry.

DNA oxidation profiles of copper phenanthrene chemical nucleases

C. Slator, Z. Molphy, A. Kellett, 2015, Front. Chem..

Process‐relevant concentrations of the leachable bDtBPP impact negatively on CHO cell production characteristics

D. Chandran, M. Henry, P. Meleady, 2016, Biotechnology progress.

C 3-symmetric opioid scaffolds are pH-responsive DNA condensation agents

Z. Molphy, V. McKee, A. Kellett, 2016, Nucleic acids research.

Synthesis, Superoxide Dismutase Mimetic and Anticancer Activities of Metal Complexes of 2,2-Dimethylpentanedioic Acid(2dmepdaH2) and 3,3-Dimethylpentanedioic acid(3dmepdaH2): X-Ray Crystal Structures of [Cu(3dmepda)(bipy)]2· 6H2O and [Cu(2dmepda)(bipy)(EtOH)]2· 4EtOH (bipy = 2,2′Bipyridine)

D. Naughton, M. Devereux, V. McKee, 2006, Bioinorganic chemistry and applications.

Assessment of DNA Topoisomerase I Unwinding Activity, Radical Scavenging Capacity, and Inhibition of Breast Cancer Cell Viability of N-alkyl-acridones and N,N′-dialkyl-9,9′-biacridylidenes

K. Papadopoulos, Z. Molphy, A. Kellett, 2019, Biomolecules.

Synthesis, X-ray crystal structures and biomimetic and anticancer activities of novel copper(II)benzoate complexes incorporating 2-(4'-thiazolyl)benzimidazole (thiabendazole), 2-(2-pyridyl)benzimidazole and 1,10-phenanthroline as chelating nitrogen donor ligands.

M. Devereux, A. Kellett, D. Egan, 2007, Journal of inorganic biochemistry.

Biological activity and coordination modes of copper(II) complexes of Schiff base-derived coumarin ligands.

M. Devereux, S. McClean, A. Kellett, 2010, Dalton transactions.

Copper(II) complexes of coumarin-derived Schiff bases and their anti-Candida activity.

M. Devereux, A. Kellett, B. Creaven, 2009, Journal of inorganic biochemistry.

Polypyridyl-Based Copper Phenanthrene Complexes: A New Type of Stabilized Artificial Chemical Nuclease.

C. Slator, Z. Molphy, V. McKee, 2018, Chemistry.

Copper phenanthrene oxidative chemical nucleases.

D. Chandran, N. Barron, C. Slator, 2014, Inorganic chemistry.

In vitro and in vivo studies into the biological activities of 1,10-phenanthroline, 1,10-phenanthroline-5,6-dione and its copper(II) and silver(I) complexes

I. Fichtner, M. Devereux, A. Kellett, 2012 .

Mapping the DNA Damaging Effects of Polypyridyl Copper Complexes with DNA Electrochemical Biosensors

A. Kellett, J. Colleran, A. Banasiak, 2022, Molecules.

DNA‐Targeted Metallodrugs: An Untapped Source of Artificial Gene Editing Technology

T. Brown, A. Kellett, Nicoló Zuin Fantoni, 2021, Chembiochem : a European journal of chemical biology.

A phosphate-targeted dinuclear Cu(II) complex combining major groove binding and oxidative DNA cleavage

C. Slator, Z. Molphy, A. Kellett, 2018, Nucleic acids research.

A new phenanthroline-oxazine ligand: synthesis, coordination chemistry and atypical DNA binding interaction.

N. Barron, M. Devereux, V. McKee, 2013, Chemical communications.

Exploring the DNA binding, oxidative cleavage, and cytotoxic properties of new ternary copper(II) compounds containing 4-aminoantipyrine and N,N-heterocyclic co-ligands

Z. Molphy, A. Kellett, K. Krambrock, 2019, Journal of Molecular Structure.

Synthesis, structure and biological activity of silver(I) complexes of substituted imidazoles

M. Devereux, V. McKee, A. Kellett, 2013 .

Di-copper metallodrugs promote NCI-60 chemotherapy via singlet oxygen and superoxide production with tandem TA/TA and AT/AT oligonucleotide discrimination

T. Brown, C. Slator, Z. Molphy, 2018, Nucleic acids research.

Molecular methods for assessment of non-covalent metallodrug–DNA interactions

N. Farrell, C. Slator, Z. Molphy, 2019, Chemical Society reviews.

A new class of prophylactic metallo-antibiotic possessing potent anti-cancer and anti-microbial properties.

B. Twamley, A. Kellett, K. Kavanagh, 2019, Dalton transactions.

Antitumor copper(II) complexes with hydroxyanthraquinones and N,N-heterocyclic ligands.

Z. Molphy, V. McKee, A. Kellett, 2023, Journal of inorganic biochemistry.

Development of Gene‐Targeted Polypyridyl Triplex‐Forming Oligonucleotide Hybrids

T. Brown, Z. Molphy, V. McKee, 2020, Chembiochem : a European journal of chemical biology.

CHAPTER 4. Recent Advances in Anticancer Copper Compounds

C. Slator, Z. Molphy, V. McKee, 2019, Metal-based Anticancer Agents.

[Cu(o-phthalate)(phenanthroline)] Exhibits Unique Superoxide-Mediated NCI-60 Chemotherapeutic Action through Genomic DNA Damage and Mitochondrial Dysfunction.

N. Barron, C. Slator, A. Kellett, 2016, ACS chemical biology.

Polypyridyl-Based Copper Phenanthrene Complexes: Combining Stability with Enhanced DNA Recognition.

M. Clynes, Z. Molphy, V. McKee, 2020, Chemistry.

Cu(ii) phenanthroline-phenazine complexes dysregulate mitochondrial function and stimulate apoptosis.

M. Devereux, Z. Molphy, A. Kellett, 2019, Metallomics : integrated biometal science.

The phosphate clamp: sequence selective nucleic acid binding profiles and conformational induction of endonuclease inhibition by cationic Triplatin complexes

N. Farrell, Z. Molphy, A. Kellett, 2014, Nucleic acids research.

Two‐Photon Polymerization: Fundamentals, Materials, and Chemical Modification Strategies

A. Pandit, A. Kellett, A. Heise, 2022, Advanced science.

[Cu(TPMA)(Phen)](ClO4)2: Metallodrug Nanocontainer Delivery and Membrane Lipidomics of a Neuroblastoma Cell Line Coupled with a Liposome Biomimetic Model Focusing on Fatty Acid Reactivity

L. Polito, A. Bolognesi, M. Louka, 2018, ACS omega.

Anticancer activity, DNA binding and cell mechanistic studies of estrogen-functionalised Cu(II) complexes

V. Gandin, A. Kellett, C. Marzano, 2019, JBIC Journal of Biological Inorganic Chemistry.

Third Generation Sequencing of Epigenetic DNA.

T. Carell, Markus Müller, A. Kellett, 2022, Angewandte Chemie.

Water-soluble and photo-stable silver(I) dicarboxylate complexes containing 1,10-phenanthroline ligands: Antimicrobial and anticancer chemotherapeutic potential, DNA interactions and antioxidant activity.

M. Devereux, S. McClean, A. Kellett, 2016, Journal of inorganic biochemistry.

ARROW@TU Dublin ARROW@TU Dublin

M. Devereux, A. Kellett, M. Mccann, 2022 .

Molecular methods for assessment of non-covalent metallodrug–DNA interactions

N. Farrell, C. Slator, Z. Molphy, 2019, Chemical Society reviews.

A Click Chemistry-Based Artificial Metallo-Nuclease.

C. Slator, V. McKee, A. Kellett, 2023, Angewandte Chemie.