M. Todd

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Open Source Research — the Power of Us

Thomas B. Kepler, Stephen M. Maurer, Matthew H. Todd, 2006 .

Experimentally Validated Pharmacoinformatics Approach to Predict hERG Inhibition Potential of New Chemical Entities

M. Todd, M. Windley, Saba Munawar, 2018, Front. Pharmacol..

Open science is a research accelerator.

Matthew H Todd, P. Olliaro, M. Todd, 2011, Nature chemistry.

Chemical sensors that incorporate click-derived triazoles.

M. Todd, P. Rutledge, Y. H. Lau, 2011, Chemical Society reviews.

Recent Advances in Macrocyclic Fluorescent Probes for Ion Sensing

Matthew H. Todd, Peter J. Rutledge, M. Todd, 2017, Molecules.

Open source drug discovery – A limited tutorial

Murray N. Robertson, Alice E. Williamson, Paul M. Ylioja, 2013, Parasitology.

Drugs for the control of parasitic diseases: current status and development in schistosomiasis.

M. Todd, A. Fenwick, L. Savioli, 2003, Trends in parasitology.

Introduction: A Survey of How and Why to Separate Enantiomers

M. Todd, 2014 .

N-Aryl Groups Are Ubiquitous in Cross-Dehydrogenative Couplings Because They Stabilize Reactive Intermediates.

Bun Chan, P. Comba, M. Todd, 2017, Chemistry.

Addressing the Most Neglected Diseases through an Open Research Model: the Discovery of Fenarimols as Novel Drug Candidates for Eumycetoma

M. Todd, Ben Perry, W. V. D. van de Sande, 2018, bioRxiv.

Rare, Neglected and Potential Synthetic Methods for the Separation of Enantiomers

M. Todd, 2014 .

Oxidative arylation of isochroman.

M. Todd, J. Price, S. J. Park, 2012, The Journal of organic chemistry.

Asymmetric autocatalysis: product recruitment for the increase in the chiral environment (PRICE).

M. Todd, 2010, Chemical Society reviews.

Six Laws of Open Source Drug Discovery

M. Todd, 2019, ChemMedChem.

In vitro metabolic profile and in vivo antischistosomal activity studies of (η(6)-praziquantel)Cr(CO)3 derivatives.

Murray N. Robertson, Murray N Robertson, J. Keiser, 2013, Journal of medicinal chemistry.

Is actin the praziquantel receptor?

M. Todd, G. Mignogna, A. Troiani, 2007, International journal of antimicrobial agents.

Solid phase synthesis of praziquantel

M. Todd, Shaimaa El-Fayyoumy, Wafaa Mansour, 2006 .

Praziquantel derivatives I: Modification of the aromatic ring.

M. Todd, D. Cioli, L. Pica-Mattoccia, 2007, Bioorganic & medicinal chemistry letters.

Open science approaches to COVID-19 [version 1; peer review: awaiting peer review]

M. Todd, E. Tse, D. Klug, 2020 .

Open science approaches to COVID-19

M. Todd, E. Tse, Dana M Klug, 2020, F1000Research.

Molecular Docking with Open Access Software: Development of an Online Laboratory Handbook and Remote Workflow for Chemistry and Pharmacy Master’s Students to Undertake Computer-Aided Drug Design

Jonathan D. Wilden, M. Todd, A. Tabor, 2021, Journal of Chemical Education.

Efficient Synthesis and Anti-Tubercular Activity of a Series of Spirocycles: An Exercise in Open Science

Katrina A. Badiola, M. Todd, J. Triccas, 2014, PloS one.

Nontoxic Metal-Cyclam Complexes, a New Class of Compounds with Potency against Drug-Resistant Mycobacterium tuberculosis.

V. Sintchenko, Mingfeng Yu, M. Todd, 2016, Journal of medicinal chemistry.

Efficient deprotection of F-BODIPY derivatives: removal of BF2 using Brønsted acids

Mingfeng Yu, M. Todd, P. Rutledge, 2015, Beilstein journal of organic chemistry.

A synthetically simple, click-generated cyclam-based zinc(II) sensor.

L. Sedger, M. Todd, E. Tamanini, 2009, Inorganic chemistry.

Cyclam-based "clickates": homogeneous and heterogeneous fluorescent sensors for Zn(II).

Levi A. Gheber, S. Piperno, L. Gheber, 2010, Inorganic chemistry.

Reversing the Triazole Topology in a Cyclam‐Triazole‐Dye Ligand Gives a 10‐Fold Brighter Signal Response to Zn2+ in Aqueous Solution

M. Todd, P. Rutledge, S. Ast, 2012 .

The C6H6 NMR repository: An integral solution to control the flow of your data from the magnet to the public

Andrés M. Castillo, S. Kuhn, Norman Pellet, 2018, Magnetic resonance in chemistry : MRC.

Incorporating a Piperidinyl Group in the Fluorophore Extends the Fluorescence Lifetime of Click-Derived Cyclam-Naphthalimide Conjugates

Mingfeng Yu, M. Todd, P. Rutledge, 2014, PloS one.

Synthesis and Evaluation of 1,8‐Disubstituted‐Cyclam/Naphthalimide Conjugates as Probes for Metal Ions

Mingfeng Yu, M. Todd, P. Rutledge, 2016, ChemistryOpen.

The past, present and future of anti-malarial medicines

M. Todd, E. Tse, Marat Korsik, 2019, Malaria Journal.

Tele-substitution Reactions in the Synthesis of a Promising Class of 1,2,4-Triazolo[4,3-a]pyrazine-Based Antimalarials.

M. Todd, W. Lewis, P. Rutledge, 2020, The Journal of organic chemistry.

Selective Displacement of a Scorpionand Triazole Ligand from Metallocyclam Complexes Visualised with NMR Spectroscopy

M. Todd, P. Rutledge, J. K. Wong, 2017 .

Activity of Praziquantel Enantiomers and Main Metabolites against Schistosoma mansoni

Murray N. Robertson, Murray N Robertson, J. Keiser, 2014, Antimicrobial Agents and Chemotherapy.

There is no market for new antibiotics: this allows an open approach to research and development

F. von Delft, A. Roberts, M. Todd, 2021, Wellcome open research.

Copper(II) complexes of N-propargyl cyclam ligands reveal a range of coordination modes and colours, and unexpected reactivity.

Mingfeng Yu, M. Todd, P. Rutledge, 2020, Dalton transactions.

Metal complexes as a promising source for new antibiotics

Justin J. Wilson, P. Sadler, M. Todd, 2019, Chemical science.

A Fluorescent “Allosteric Scorpionand” Complex Visualizes a Biological Recognition Event

Mingfeng Yu, M. Todd, P. Rutledge, 2013, Chembiochem : a European journal of chemical biology.

Molecular Switches for any pH: A Systematic Study of the Versatile Coordination Behaviour of Cyclam Scorpionands.

J. Clegg, M. Todd, P. Rutledge, 2018, Chemistry.

The past, present and future of anti-malarial medicines

M. Todd, E. Tse, Marat Korsik, 2019, Malaria Journal.

Oxidative arylation of isochroman.

M. Todd, J. Price, S. J. Park, 2012, The Journal of organic chemistry.

Gold-Catalysis: Reactions of Organogold Compounds with Electrophiles

M. Todd, A. Hashmi, Althea S.‐K. Tsang, 2010 .

Enhancing the usefulness of cross dehydrogenative coupling reactions with a removable protecting group.

D. B. Hibbert, J. Keiser, M. Todd, 2013, Organic & biomolecular chemistry.

Aza‐Henry Reactions of 3,4‐Dihydroisoquinoline

M. Todd, Muneer Ahamed, P. Jensen, 2010 .

The First Catalytic, Enantioselective Aza‐Henry Reaction of an Unactivated Cyclic Imine

M. Todd, P. Turner, N. R. Amarasinghe, 2012 .

Amino acid derived heterocycles: lewis acid catalyzed and radical cyclizations from peptide acetals.

M. Todd, P. Bartlett, Chudi O. Ndubaku, 2002, The Journal of organic chemistry.

Design and synthesis of new tetrazolyl- and carboxy-biphenylylmethyl-quinazolin-4-one derivatives as angiotensin II AT1 receptor antagonists.

Matthew H Todd, K. Abouzid, M. Todd, 2006, Journal of medicinal chemistry.

Facile synthesis of vicinal diamines via oxidation of N -phenyltetrahydroisoquinolines with DDQ

M. Todd, Althea S.‐K. Tsang, 2009 .

Catalytic Asymmetric Additions of Carbon‐Centered Nucleophiles to Nitrogen‐Containing Aromatic Heterocycles

M. Todd, Muneer Ahamed, 2010 .

The Outcome of the Oxidations of Unusual Enediamide Motifs Is Governed by the Stabilities of the Intermediate Iminium Ions

M. Todd, Muneer Ahamed, P. Jensen, 2012, PloS one.

Studies on the Synthesis, Characterisation and Reactivity of Aromatic Diboronic Acids

S. Balasubramanian, C. Abell, M. Todd, 1997 .

An oxidative carbon–carbon bond-forming reaction proceeds via an isolable iminium ion

M. Todd, J. Hook, A. Hashmi, 2011 .

Correction: Metal complexes as a promising source for new antibiotics

Justin J. Wilson, P. Sadler, M. Todd, 2020, Chemical science.

A click fluorophore sensor that can distinguish Cu(II) and Hg(II) via selective anion-induced demetallation.

M. Todd, P. Rutledge, Y. H. Lau, 2011, Chemistry.

Facile Synthesis of Vicinal Diamines via Oxidation of N-Phenyltetrahydroisoquinolines with DDQ.

M. Todd, Althea S.‐K. Tsang, 2009 .

Separation of Enantiomers: Synthetic Methods

M. Todd, 2014 .

Responsive metal complexes: a click-based "allosteric scorpionate" complex permits the detection of a biological recognition event by EPR/ENDOR spectroscopy.

M. Todd, S. Rigby, E. Tamanini, 2009, Chemistry.

The attachment and cleavage of phenols from solid supports and their single bead mass spectral analysis

C. Abell, M. Todd, 2000 .

Can we measure catalyst efficiency in asymmetric chemical reactions? A theoretical approach

M. Todd, C. Richards, Shaimaa El-Fayyoumy, 2009, Beilstein journal of organic chemistry.

Synthesis of elongated cavitands via click reactions and their use as chemosensors

M. Todd, L. Kiss, S. Kunsági-Máté, 2013 .

Asymmetric Autocatalysis: Product Recruitment for the Increase in the Chiral Environment (PRICE)

Matthew H. Todd, M. Todd, 2010 .

Resolution of Praziquantel

Matthew H. Todd, Kees Pouwer, J. Seerden, 2011, PLoS neglected tropical diseases.

Polyamide-Scorpion Cyclam Lexitropsins Selectively Bind AT-Rich DNA Independently of the Nature of the Coordinated Metal

Noeris K. Salam, D. Hibbs, M. Todd, 2011, PloS one.

Addressing the most neglected diseases through an open research model: The discovery of fenarimols as novel drug candidates for eumycetoma

Matthew H Todd, Wilson Lim, M. Todd, 2018, bioRxiv.

through the of as

M. Todd, W. Lim, K. Eadie, 2018 .

In vivo antischistosomal activity studies and in vitro metabolic profile of (η6-Praziquantel)Cr(CO)3 derivatives

Murray N. Robertson, Murray N Robertson, J. Keiser, 2013 .

A critical overview of computational approaches employed for COVID-19 drug discovery

Tudor I. Oprea, Rommie E. Amaro, G. Schneider, 2021, Chemical Society reviews.

Using Click Chemistry to Tune the Properties and the Fluorescence Response Mechanism of Structurally Similar Probes for Metal Ions

M. Todd, P. Rutledge, S. Ast, 2015 .

Improved synthesis of the valuable peptidomimetic intermediate 3-azido-4-hydroxy cyclopentanoic acid

M. Todd, E. Tamanini, M. Watkinson, 2006 .

An Open Drug Discovery Competition: Experimental Validation of Predictive Models in a Series of Novel Antimalarials.

Benedict Irwin, Benedict W J Irwin, Gareth Conduit, 2020, Journal of medicinal chemistry.

Non-Classical Phenyl Bioisosteres as Effective Replacements in a Series of Novel Open Source Antimalarials.

G. S. Walker, Mark B. Anderson, R. Obach, 2020, Journal of medicinal chemistry.

The use of FTICR-MS to detect chemical tags from a combinatorial library.

C. Abell, M. Todd, 2002, The Analyst.

Novel chemical tagging method for combinatorial synthesis utilizing suzuki chemistry and fourier transform ion cyclotron resonance mass spectrometry.

C. Abell, M. Todd, 2001, Journal of combinatorial chemistry.

Synthesis and DNA binding ability of cyclam-amino acid conjugates.

M. Todd, M. Watkinson, A. Venkata Ramana, 2008, Bioorganic & medicinal chemistry letters.

Neuroprotective peptide-macrocycle conjugates reveal complex structure-activity relationships in their interactions with amyloid β.

A. Bush, Mingfeng Yu, T. Ryan, 2014, Metallomics : integrated biometal science.

Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles

Julie Clark, George Papadatos, Jeremy N. Burrows, 2016, ACS central science.

Perphenazine-macrocycle conjugates divert Aβ42 towards non-toxic aggregates by monomer sequestration

M. Kassiou, M. Sunde, A. Kwan, 2020, bioRxiv.

Target 2035 – update on the quest for a probe for every protein

G. A. Bezerra, T. Willson, G. Superti-Furga, 2021, RSC medicinal chemistry.

Experiences with a researcher-centric ELN† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c4sc02128b Click here for additional data file.

Erica Yang, Nicola Knight, Colin Bird, 2014, Chemical science.

An open source pharma roadmap

John Wilbanks, Manica Balasegaram, Els Torreele, 2017, PLoS medicine.

A Kernel for Open Source Drug Discovery in Tropical Diseases

Narayanan Eswar, Ursula Pieper, Andrej Sali, 2009, PLoS neglected tropical diseases.

A kernel for the Tropical Disease Initiative

Narayanan Eswar, Ursula Pieper, Marc A Marti-Renom, 2009, Nature Biotechnology.

Easy-To-Synthesize Spirocyclic Compounds Possess Remarkable in Vivo Activity against Mycobacterium tuberculosis.

Katrina A. Badiola, M. Todd, P. Rutledge, 2018, Journal of medicinal chemistry.

The properties and performance of a pH-responsive functionalised nanoparticle.

M. Todd, P. Rutledge, S. Ast, 2014, Faraday discussions.

Perphenazine-macrocycle conjugates divert Aβ42 towards non-toxic aggregates by monomer sequestration

M. Kassiou, M. Sunde, A. Kwan, 2020, bioRxiv.

A direct method for the N-tetraalkylation of azamacrocycles

M. Todd, P. Rutledge, Andrew J Counsell, 2016, Beilstein journal of organic chemistry.

Incorporation of Bulky and Cationic Cyclam-Triazole Moieties into Marimastat Can Generate Potent MMP Inhibitory Activity without Inducing Cytotoxicity

Mingfeng Yu, M. Todd, P. Rutledge, 2013, ChemistryOpen.

Copper, nickel, and zinc cyclam-amino acid and cyclam-peptide complexes may be synthesized with "click" chemistry and are noncytotoxic.

Mingfeng Yu, M. Todd, L. Windus, 2011, Inorganic chemistry.

Target 2035 – an update on private sector contributions

T. Willson, S. Knapp, U. Lessel, 2023, RSC medicinal chemistry.

Structure-Property Optimization of a Series of Imidazopyridines for Visceral Leishmaniasis.

M. Todd, Ben Perry, E. Tse, 2023, ACS infectious diseases.

Computer-aided organic synthesis.

Matthew H Todd, M. Todd, 2005, Chemical Society reviews.

Perphenazine-Macrocycle Conjugates Rapidly Sequester the Aβ42 Monomer and Prevent Formation of Toxic Oligomers and Amyloid.

M. Kassiou, M. Sunde, A. Kwan, 2022, ACS chemical neuroscience.

Antitubercular Bis-Substituted Cyclam Derivatives: Structure-Activity Relationships and in Vivo Studies.

M. Todd, P. Rutledge, J. Triccas, 2018, Journal of medicinal chemistry.

CACHE (Critical Assessment of Computational Hit-finding Experiments): A public–private partnership benchmarking initiative to enable the development of computational methods for hit-finding

Tudor I. Oprea, Rommie E. Amaro, Yoshua Bengio, 2021, Nature Reviews Chemistry.

pH-Responsive quantum dots (RQDs) that combine a fluorescent nanoparticle with a pH-sensitive dye.

M. Todd, P. Rutledge, Sandra Ast, 2014, Physical chemistry chemical physics : PCCP.

Chemotherapeutic Development Strategies for Schistosomiasis

J. Utzinger, J. Keiser, D. Nelson, 2009 .

Neuroprotective peptide-macrocycle conjugates reveal complex structure-activity relationships in their interactions with amyloid β.

A. Bush, Mingfeng Yu, T. Ryan, 2014, Metallomics : integrated biometal science.

A direct method for the N-tetraalkylation of azamacrocycles

M. Todd, P. Rutledge, Andrew J Counsell, 2016, Beilstein journal of organic chemistry.

Synthesis and Evaluation of 1,8‐Disubstituted‐Cyclam/Naphthalimide Conjugates as Probes for Metal Ions

Mingfeng Yu, M. Todd, P. Rutledge, 2016, ChemistryOpen.

Effective methods for the biotinylation of azamacrocycles.

M. Todd, E. Tamanini, M. Watkinson, 2007, The Journal of organic chemistry.