A. Russell

发表

Anthelmintic drug discovery: target identification, screening methods and the role of open science

G. Wynne, D. Sattelle, Ruth Forman, 2020, Beilstein journal of organic chemistry.

Characterisation of utrophin modulator SMT C1100 as a non-competitive inhibitor of firefly luciferase.

G. Wynne, A. Russell, Elisabete Pires, 2019, Bioorganic chemistry.

Structure-based development of new RAS-effector inhibitors from a combination of active and inactive RAS-binding compounds.

S. Phillips, T. Rabbitts, Ami Miller, 2019 .

Structure-based development of new RAS-effector inhibitors from a combination of active and inactive RAS-binding compounds

S. Phillips, T. Rabbitts, Ami Miller, 2019, Proceedings of the National Academy of Sciences.

Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment

Narcis Fernandez-Fuentes, S. Phillips, T. Rabbitts, 2018, Nature Communications.

Exploration of Piperidinols as Potential Antitubercular Agents

P. Finn, G. Morris, A. Russell, 2014, Molecules.

A biased agonist at immunometabolic receptor GPR84 causes distinct functional effects in macrophages.

G. Wynne, D. Greaves, M. Chatzopoulou, 2019, ACS chemical biology.

A systematic study of the solid state and solution phase conformational preferences of β-peptides derived from transpentacin

J. E. Thomson, Lorna J. Smith, G. Tranter, 2010 .

An automated high-throughput system for phenotypic screening of chemical libraries on C. elegans and parasitic nematodes

Anwen E. Brown, G. Wynne, S. Buckingham, 2017, bioRxiv.

The Role of Metabolite-Sensing G Protein-Coupled Receptors in Inflammation and Metabolic Disease.

G. Wynne, D. Greaves, C. Monaco, 2017, Antioxidants & redox signaling.

Electrochemical kinetics of Ag|Ag+ and TMPD|TMPD+ in the room-temperature ionic liquid [C4mpyrr][NTf2]; toward optimizing reference electrodes for voltammetry in RTILs

R. Compton, A. Russell, C. Hardacre, 2007 .

Solution phase structures of enantiopure and racemic lithium N-benzyl-N-(α-methylbenzyl)amide in THF: low temperature 6Li and 15N NMR spectroscopic studies

J. E. Thomson, A. Russell, S. Davies, 2013 .

A cell-based screening method using an intracellular antibody for discovering small molecules targeting the translocation protein LMO2

T. Rabbitts, Ami Miller, F. Raynaud, 2021, Science Advances.

From diagnosis to therapy in Duchenne muscular dystrophy

G. Wynne, K. Davies, M. Chatzopoulou, 2020, Biochemical Society transactions.

BRET-based RAS biosensors that show a novel small molecule is an inhibitor of RAS-effector protein-protein interactions

S. Phillips, T. Rabbitts, Ami Miller, 2018, eLife.

Simvastatin activates single skeletal RyR1 channels but exerts more complex regulation of the cardiac RyR2 isoform

E. Venturi, R. Sitsapesan, Sabine Lotteau, 2018, British journal of pharmacology.

Iodine-mediated ring-closing iodoamination with concomitant N-debenzylation for the asymmetric synthesis of polyhydroxylated pyrrolidines

J. E. Thomson, A. Russell, S. Davies, 2009 .

20 Years an Orphan: Is GPR84 a Plausible Medium-Chain Fatty Acid-Sensing Receptor?

D. Greaves, C. Bataille, A. Russell, 2020, DNA and cell biology.

A structural study of the interaction between the Dr haemagglutinin DraE and derivatives of chloramphenicol

P. Roversi, A. Russell, S. Lea, 2009, Acta crystallographica. Section D, Biological crystallography.

Experimental limitations of extracellular vesicle-based therapies for the treatment of myocardial infarction

A. Russell, P. Riley, Tahnee L. Kennedy, 2020, Trends in cardiovascular medicine.

Synthesis of SMT022357 enantiomers and in vivo evaluation in a Duchenne muscular dystrophy mouse model

J. E. Thomson, G. Wynne, K. Davies, 2020, Tetrahedron.

Augmentation of Creatine in the Heart

S. Zervou, A. Russell, C. Lygate, 2015, Mini reviews in medicinal chemistry.

Decreasing HepG2 Cytotoxicity by Lowering the Lipophilicity of Benzo[d]oxazolephosphinate Ester Utrophin Modulators.

G. Wynne, K. Davies, L. Moir, 2020, ACS medicinal chemistry letters.

A chemical tool for improved culture of human pluripotent stem cells

C. Bataille, A. Russell, M. Stevenson, 2020, bioRxiv.

2,4-Diaminothieno[3,2-d]pyrimidines, a new class of anthelmintic with activity against adult and egg stages of whipworm

Anwen E. Brown, G. Wynne, D. Sattelle, 2018, bioRxiv.

Pilot Study to Quantify Palladium Impurities in Lead-like Compounds Following Commonly Used Purification Techniques

G. Wynne, M. Chatzopoulou, A. Russell, 2022, ACS medicinal chemistry letters.

Chemical Instability and Promiscuity of Arylmethylidenepyrazolinone-Based MDMX Inhibitors

G. Wynne, T. Lundbäck, C. Bataille, 2018, ACS chemical biology.

An outer-pore gate modulates the pharmacology of the TMEM16A channel

P. Stansfeld, A. Russell, P. Tammaro, 2021, Proceedings of the National Academy of Sciences.

Evaluating the efficacy and safety of a novel prophylactic nasal spray in the prevention of SARS-CoV-2 infection: A multi-centre, double blind, placebo-controlled, randomised trial.

A. Dunton, A. Russell, Á. McKnight, 2022, Journal of Clinical Virology.

Probing Competitive and Co-operative Hydroxyl and Ammonium Hydrogen-Bonding Directed Epoxidations.

James A. Lee, J. E. Thomson, A. Russell, 2017, The Journal of organic chemistry.

Structure-activity relationships of 2-pyrimidinecarbohydrazides as utrophin modulators for the potential treatment of Duchenne muscular dystrophy.

S. Davies, G. Wynne, M. Chatzopoulou, 2022, Bioorganic & Medicinal Chemistry.

2-Arylbenzo[d]oxazole phosphinate esters as second-generation modulators of utrophin for the treatment of Duchenne Muscular Dystrophy.

G. Wynne, K. Davies, L. Moir, 2020, Journal of medicinal chemistry.

Isolation, structural identification, synthesis, and pharmacological profiling of 1,2-trans-dihydro-1,2-diol metabolites of the utrophin modulator ezutromid.

G. Wynne, K. Davies, M. Chatzopoulou, 2019, Journal of medicinal chemistry.

Beta-fluoroamphetamines via the stereoselective synthesis of benzylic fluorides.

James A. Lee, J. E. Thomson, A. Russell, 2010, Organic letters.

The Derivation of Primary Human Epicardium-Derived Cells.

M. Goumans, C. Antoniades, D. Yellon, 2015, Current protocols in stem cell biology.

A tubulin binding molecule drives differentiation of acute myeloid leukemia cells

Edward W. Tate, Stephen G. Davies, P. Vyas, 2022, iScience.

Screening the Medicines for Malaria Venture (MMV) Pandemic Response Box chemical library on Caenorhabditis elegans identifies re-profiled candidate anthelmintic drug leads

D. Sattelle, Ruth Forman, K. Else, 2022, Frontiers in Tropical Diseases.

Statin activation of skeletal ryanodine receptors (RyR1) is a class effect but separable from HMG‐CoA reductase inhibition

R. Sitsapesan, A. Russell, Maria Musgaard, 2022, British Journal of Pharmacology.

Asymmetric synthesis of N,O,O,O-tetra-acetyl d-lyxo-phytosphingosine, jaspine B (pachastrissamine), 2-epi-jaspine B, and deoxoprosophylline via lithium amide conjugate addition.

J. E. Thomson, A. Russell, S. Davies, 2008, Organic & biomolecular chemistry.

Digoxin pharmacokinetics: multicompartmental analysis and its clinical implications.

A. Russell, D. Sumner, 1976, British journal of clinical pharmacology.

Stereoselective functionalisation of SuperQuat enamides: asymmetric synthesis of homochiral 1,2-diols and α-benzyloxy carbonyl compounds

J. E. Thomson, A. Russell, S. Davies, 2008 .

An outer pore gate controls the pharmacology of the TMEM16A channel 2

A. Russell, P. Tammaro, Emilio Agostinelli, 2021 .

Novel small-molecule inhibitors of arylamine N-acetyltransferases: drug discovery by high-throughput screening.

A. Russell, S. Davies, E. Sim, 2011, Combinatorial chemistry & high throughput screening.

Discovery and mechanism of action studies of 4,6-diphenylpyrimidine-2-carbohydrazides as utrophin modulators for the treatment of Duchenne muscular dystrophy.

G. Wynne, K. Davies, M. Chatzopoulou, 2021, European journal of medicinal chemistry.

Differences between murine arylamine N-acetyltransferase type 1 and human arylamine N-acetyltransferase type 2 defined by substrate specificity and inhibitor binding

A. Russell, L. Stanley, E. Sim, 2014, BMC Pharmacology and Toxicology.

Asymmetric synthesis of piperidines and octahydroindolizines using a one-pot ring-closure/N-debenzylation procedure

James A. Lee, J. E. Thomson, A. Russell, 2011 .

Jaspine B (pachastrissamine) and 2-epi-jaspine B: synthesis and structural assignment

J. E. Thomson, A. Russell, S. Davies, 2008 .

Evaluating beta-amino acids as enantioselective organocatalysts of the Hajos-Parrish-Eder-Sauer-Wiechert reaction.

J. E. Thomson, A. Russell, S. Davies, 2007, Organic & biomolecular chemistry.

A novel tubulin binding molecule drives differentiation of acute myeloid leukaemia cells

Edward W. Tate, P. Vyas, G. Wynne, 2021, bioRxiv.

Strategies for the construction of morphinan alkaloid AB-rings: regioselective Friedel-Crafts-type cyclisations of γ-aryl-β-benzoylamido acids with asymmetrically substituted γ-aryl rings

J. E. Thomson, A. Russell, S. Davies, 2016 .

Homochiral lithium amides for the asymmetric synthesis of β-amino acids

A. Russell, O. Ichihara, S. Davies, 2006 .

Enantiopure 3-Amino-Substituted 1-Indanones, 1-Tetralones, and 1-Benzosuberones via Friedel-Crafts Cyclisation of ω-Aryl-β-benzamido Acids

J. E. Thomson, A. Russell, S. Davies, 2015 .

Chemo- and diastereoselective cyclopropanation of allylic amines and carbamates

James A. Lee, J. E. Thomson, A. Russell, 2010 .

Asymmetric synthesis of tetrahydrolipstatin and valilactone

J. E. Thomson, A. Russell, S. Davies, 2008 .

Asymmetric Synthesis of β2‐Amino Acids: 2‐Substituted‐3‐aminopropanoic Acids from N‐Acryloyl SuperQuat Derivatives.

J. E. Thomson, A. Russell, S. Davies, 2008 .

Asymmetric synthesis of beta2-amino acids: 2-substituted-3-aminopropanoic acids from N-acryloyl SuperQuat derivatives.

J. E. Thomson, A. Russell, S. Davies, 2007, Organic & biomolecular chemistry.

Small molecule colorimetric probes for specific detection of human arylamine N-acetyltransferase 1, a potential breast cancer biomarker.

Akane Kawamura, Edith Sim, James Robinson, 2010, Journal of the American Chemical Society.

Asymmetric synthesis of 2-alkyl- and 2-aryl-3-aminopropionic acids (beta2-amino acids) from (S)-N-acryloyl-5,5-dimethyloxazolidin-2-one SuperQuat derivatives.

A. Russell, S. Davies, Andrew D. Smith, 2004, Chemical communications.

Statin activation of skeletal ryanodine receptors (RyR1) is a class effect but separable from HMG‐CoA reductase inhibition

R. Sitsapesan, A. Russell, Maria Musgaard, 2021, British journal of pharmacology.

Design, synthesis and structure-activity relationships of 3,5-diaryl-1H-pyrazoles as inhibitors of arylamine N-acetyltransferase.

A. Russell, S. Davies, E. Sim, 2013, Bioorganic & medicinal chemistry letters.

Identification of arylamine N-acetyltransferase inhibitors as an approach towards novel anti-tuberculars

G. Besra, A. Russell, S. Bhakta, 2010, Protein & Cell.

Doubly diastereoselective conjugate addition of homochiral lithium amides to homochiral alpha,beta-unsaturated esters containing cis- and trans-dioxolane units.

James A. Lee, A. Russell, S. Davies, 2009, Organic & biomolecular chemistry.

Conjugate addition of lithium N-tert-butyldimethylsilyloxy-N-(α-methylbenzyl)amide: asymmetric synthesis of β2,2,3-trisubstituted amino acids

James A. Lee, J. E. Thomson, A. Russell, 2010 .

Optimization of 3,5-Dimethylisoxazole Derivatives as Potent Bromodomain Ligands

S. Knapp, O. Fedorov, P. Brennan, 2013, Journal of medicinal chemistry.

Asymmetric synthesis of beta-amino-gamma-substituted-gamma-butyrolactones: double diastereoselective conjugate addition of homochiral lithium amides to homochiral alpha,beta-unsaturated esters.

J. E. Thomson, A. Russell, S. Davies, 2007, Organic & biomolecular chemistry.

Parallel kinetic resolution of methyl (RS)-5-tris(phenylthio)methyl-cyclopent-1-ene-carboxylate for the asymmetric synthesis of (1R,2S,5S)- and (1S,2R,5R)-5-methyl-cispentacin

J. E. Thomson, A. Russell, S. Davies, 2008 .

Highly diastereoselective and stereodivergent dihydroxylations of acyclic allylic amines: application to the asymmetric synthesis of 3,6-dideoxy-3-amino-L-talose.

James A. Lee, J. E. Thomson, A. Russell, 2011, Organic letters.

Ammonium-directed dihydroxylation of 3-aminocyclohex-1-enes: development of a metal-free dihydroxylation protocol.

J. E. Thomson, A. Russell, S. Davies, 2008, Organic & biomolecular chemistry.

An oxidatively-activated safety catch linker for solid phase synthesis.

A. Russell, S. Davies, Andrew D. Smith, 2008, Organic & biomolecular chemistry.

Highly (E)-selective Wadsworth-Emmons reactions promoted by methylmagnesium bromide.

James A. Lee, A. Russell, S. Davies, 2008, Organic letters.

Polysubstituted piperidines via iodolactonization: application to the asymmetric synthesis of (+)-pseudodistomin D.

James A. Lee, J. E. Thomson, A. Russell, 2012, Organic letters.

Parallel kinetic resolution of tert -butyl ( RS )-6-alkyl-cyclohex-1-ene-carboxylates for the asymmetric synthesis of 6-alkyl-substituted cishexacin derivatives

J. E. Thomson, A. Russell, S. Davies, 2008 .

Parallel synthesis of homochiral β-amino acids

A. Russell, S. Davies, Andrew D. Smith, 2007 .

Homochiral Lithium Amides for the Asymmetric Synthesis of β-Amino Acids.

A. Russell, O. Ichihara, S. Davies, 2006 .

Ammonium-directed dihydroxylation: metal-free synthesis of the diastereoisomers of 3-aminocyclohexane-1,2-diol.

J. E. Thomson, A. Russell, S. Davies, 2008, Organic & biomolecular chemistry.

A systematic study of the solid state and solution phase conformational preferences of β-peptides derived from C(3)-alkyl substituted transpentacin derivatives

J. E. Thomson, Lorna J. Smith, G. Tranter, 2011 .

β-Fluoroamphetamines via the Stereoselective Synthesis of Benzylic Fluorides.

James A. Lee, J. E. Thomson, A. Russell, 2010 .

Asymmetric synthesis of piperidines and octahydroindolizines

J. E. Thomson, A. Russell, S. Davies, 2010 .

Structural Requirements for Dihydrobenzoxazepinone Anthelmintics: Actions against Medically Important and Model Parasites: Trichuris muris, Brugia malayi, Heligmosomoides polygyrus, and Schistosoma mansoni

G. Wynne, J. Keiser, J. Archer, 2021, ACS infectious diseases.

Structural requirements for dihydrobenzoxazepinone anthelmintics: actions against medically important and model parasites - Trichuris muris, Brugia malayi and Heligmosomoides polygyrus

J. Keiser, J. Archer, D. Sattelle, 2020, bioRxiv.

Inhibition of mycobacterial arylamine N-acetyltransferase contributes to anti-mycobacterial activity of Warburgia salutaris.

Peter J. Smith, A. Russell, S. Bhakta, 2007, Bioorganic & medicinal chemistry.

Chemical Proteomics and Phenotypic Profiling Identifies the Aryl Hydrocarbon Receptor as a Molecular Target of the Utrophin Modulator Ezutromid

G. Wynne, K. Davies, S. Mohammed, 2019, Angewandte Chemie.

Asymmetric synthesis of N,O,O,O-tetra-acetyl d-lyxo-phytosphingosine, jaspine B (pachastrissamine) and its C(2)-epimer

J. E. Thomson, A. Russell, S. Davies, 2007 .

The stereodivergent aziridination of allylic carbamates, amides and sulfonamides

J. E. Thomson, A. Russell, S. Davies, 2010 .

Syntheses of Dihydroconduramines (±)-B-1, (±)-E-1, and (±)-F-1 via Diastereoselective Epoxidation of N-Protected 4-Aminocyclohex-2-en-1-ols.

James A. Lee, J. E. Thomson, A. Russell, 2015, The Journal of organic chemistry.

Epoxidation of trans-4-Aminocyclohex-2-en-1-ol Derivatives: Competition of Hydroxy-Directed and Ammonium-Directed Pathways*

James A. Lee, J. E. Thomson, A. Russell, 2015 .

Diastereoselective Simmons-Smith cyclopropanations of allylic amines and carbamates.

J. E. Thomson, A. Russell, S. Davies, 2007, Chemical communications.

Diastereoselective Simmons—Smith Cyclopropanations of Allylic Amines and Carbamates.

J. E. Thomson, A. Russell, S. Davies, 2008 .

A Genomic DNA Reporter Screen Identifies Squalene Synthase Inhibitors That Act Cooperatively with Statins to Upregulate the Low-Density Lipoprotein Receptor

G. Wynne, G. Douglas, A. Hale, 2017, The Journal of Pharmacology and Experimental Therapeutics.

The BET inhibitor CPI203 promotes ex vivo expansion of cord blood long-term repopulating HSCs and megakaryocytes.

G. Wynne, Rong Li, J. Hester, 2020, Blood.

Ammonium-directed oxidation of cyclic allylic and homoallylic amines.

James A. Lee, J. E. Thomson, A. Russell, 2009, Journal of Organic Chemistry.

"Pure by NMR"?

A. Russell, S. Davies, E. Savory, 2008, Organic letters.

Abrogation of E‐Cadherin‐Mediated Cell–Cell Contact in Mouse Embryonic Stem Cells Results in Reversible LIF‐Independent Self‐Renewal

A. Russell, N. Bobola, R. Kemler, 2009, Stem cells.

From Arylamine N-Acetyltransferase to Folate-Dependent Acetyl CoA Hydrolase: Impact of Folic Acid on the Activity of (HUMAN)NAT1 and Its Homologue (MOUSE)NAT2

A. Russell, L. Stanley, E. Sim, 2014, PLoS ONE.

1.13 – Regenerative Medicine

G. Wynne, A. Russell, S. Davies, 2017 .

Stemistry: the control of stem cells in situ using chemistry.

G. Wynne, A. Russell, S. Davies, 2015, Journal of medicinal chemistry.

Combining experimental strategies for successful target deconvolution.

Georg C Terstappen, Isabel V L Wilkinson, Angela J Russell, 2020, Drug discovery today.

Thiazolidine derivatives as potent and selective inhibitors of the PIM kinase family.

Simon Byrne, S. Knapp, G. Wynne, 2017, Bioorganic & medicinal chemistry.

Structure-activity relationships and colorimetric properties of specific probes for the putative cancer biomarker human arylamine N-acetyltransferase 1.

G. Wynne, A. Russell, E. Sim, 2014, Bioorganic & medicinal chemistry.

Selective small molecule inhibitors of the potential breast cancer marker, human arylamine N-acetyltransferase 1, and its murine homologue, mouse arylamine N-acetyltransferase 2.

James Robinson, E. Lowe, A. Russell, 2009, Bioorganic & medicinal chemistry.

DLL4-Notch signaling mediates tumor resistance to anti-VEGF therapy in vivo.

A. Harris, R. Poulsom, Herren Wu, 2011, Cancer research.

Disrupting Hypoxia-Induced Bicarbonate Transport Acidifies Tumor Cells and Suppresses Tumor Growth.

A. Harris, E. Bridges, A. McIntyre, 2016, Cancer research.

Dihydrobenz[e][1,4]oxazepin-2(3H)-ones, a new anthelmintic chemotype immobilising whipworm and reducing infectivity in vivo

G. Wynne, D. Sattelle, Ruth Forman, 2017, PLoS neglected tropical diseases.

Recent Advances in Small Molecule Stimulation of Regeneration and Repair.

A. Russell, Laurence Silpa, Rachel Sim, 2022, Bioorganic & medicinal chemistry letters.

Activation of the Immune-Metabolic Receptor GPR84 Enhances Inflammation and Phagocytosis in Macrophages

G. Wynne, D. Greaves, C. Monaco, 2018, Front. Immunol..

Hedgehog and Bmp polarize hematopoietic stem cell emergence in the zebrafish dorsal aorta.

D. Kimelman, M. Gering, A. Russell, 2009, Developmental cell.

Identification and Preliminary Structure-Activity Relationship Studies of 1,5-Dihydrobenzo[e][1,4]oxazepin-2(3H)-ones That Induce Differentiation of Acute Myeloid Leukemia Cells In Vitro

P. Vyas, G. Wynne, T. Milne, 2021, Molecules.

A phenotypic screen identifies a compound series that induces differentiation of acute myeloid leukemia cells in vitro and shows anti-tumour effects in vivo

P. Vyas, G. Wynne, T. Milne, 2020, bioRxiv.

Second-generation compound for the modulation of utrophin in the therapy of DMD

G. Wynne, K. Davies, A. Russell, 2015, Human molecular genetics.

The Dimroth rearrangement as a probable cause for structural misassignments in imidazo[1,2-a]pyrimidines: A N-labelling study and an easy method for the determination of regiochemistry

G. Wynne, M. Chatzopoulou, A. Russell, 2018, Tetrahedron.

Tumor and Stem Cell Biology DLL 4-Notch Signaling Mediates Tumor Resistance to Anti-VEGF Therapy In Vivo

A. Harris, R. Poulsom, Herren Wu, 2011 .

Primary Macrophage Chemotaxis Induced by Cannabinoid Receptor 2 Agonists Occurs Independently of the CB2 Receptor

D. Greaves, A. Russell, T. Kapellos, 2015, Scientific Reports.

Ligand-based virtual screening identifies a family of selective cannabinoid receptor 2 agonists

G. Wynne, D. Greaves, C. Bataille, 2015, Bioorganic & medicinal chemistry.

A GAA repeat expansion reporter model of Friedreich's ataxia recapitulates the genomic context and allows rapid screening of therapeutic compounds.

A. Russell, R. Wade-Martins, A. Nemeth, 2013, Human molecular genetics.

Structure and mechanism of arylamine N-acetyltransferases.

A. Russell, S. Davies, E. Sim, 2006, Current topics in medicinal chemistry.

Temperature stability of proteins essential for the intracellular survival of Mycobacterium tuberculosis.

A. Russell, N. Lack, E. Sim, 2009, The Biochemical journal.

Piperidinols That Show Anti-Tubercular Activity as Inhibitors of Arylamine N-Acetyltransferase: An Essential Enzyme for Mycobacterial Survival Inside Macrophages

E. Garman, D. Staunton, E. Lowe, 2012, PloS one.

Analysis of β-amino alcohols as inhibitors of the potential anti-tubercular target N-acetyltransferase.

A. Russell, S. Davies, E. Sim, 2011, Bioorganic & medicinal chemistry letters.

A Novel Color Change Mechanism for Breast Cancer Biomarker Detection: Naphthoquinones as Specific Ligands of Human Arylamine N-Acetyltransferase 1

A. Russell, E. Sim, J. Dairou, 2013, PloS one.

Aminothiazolones as potent, selective and cell active inhibitors of the PIM kinase family.

Simon Byrne, S. Knapp, G. Wynne, 2020, Bioorganic & medicinal chemistry.

Chemical-Induced Naive Pluripotency.

A. Russell, Laurence Silpa, 2016, Cell chemical biology.

Human Arylamine N-Acetyltransferase Type 1 and Breast Cancer

A. Russell, N. Laurieri, James E. Egleton, 2018 .

Phenotypic screening identifies a trisubstituted imidazo[1,2-a]pyridine series that induces differentiation in multiple AML cell lines.

P. Vyas, G. Wynne, T. Milne, 2023, European journal of medicinal chemistry.

Inhibition of striatal dopamine release by the L-type calcium channel inhibitor isradipine co-varies with risk factors for Parkinson’s

S. Cragg, C. Bataille, A. Russell, 2020, bioRxiv.

Screening the Medicines for Malaria Pandemic Response Box chemical library on Caenorhabditis elegans identifies re-profiled candidate anthelmintic drug leads

D. Sattelle, Ruth Forman, K. Else, 2022, bioRxiv.

Phenotypic screen-based discovery of a small molecule that can increase adult neurogenesis and improve memory

C. Webber, D. Bannerman, A. Hoerder-Suabedissen, 2023, bioRxiv.

Medicinal chemistry and drug discovery in an opening era

C. Southan, G. Wynne, D. Sattelle, 2020 .

Developmental Expression of the Cell Cycle Regulator p16INK4a in Retinal Glial Cells: A Novel Marker for Immature Ocular Astrocytes?

R. MacLaren, A. Russell, T. Burgoyne, 2023, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

An oxidation and ring contraction approach to the synthesis of (+/-)-1-deoxynojirimycin and (+/-)-1-deoxyaltronojirimycin.

James A. Lee, A. Russell, S. Davies, 2010, Organic letters.

Evaluating the efficacy and safety of a novel prophylactic nasal spray in the prevention of SARS-CoV-2 infection: A multi-centre, double blind, placebo-controlled, randomised trial. Journal of Clinical Virology

A. Dunton, A. Russell, Á. McKnight, 2022 .

Kinetic insights into agonist-dependent signalling bias at the pro-inflammatory G-protein coupled receptor GPR84.

D. Greaves, C. Bataille, A. Russell, 2023, European journal of pharmacology.

KRAS full length G12V GPPNHP

S. Phillips, T. Rabbitts, Ami Miller, 2019 .

Regenerative medicinal chemistry: the in situ control of stem cells.

A. Russell, 2013, ACS Medicinal Chemistry Letters.

A pharmacophore-based approach to demonstrating the scope of alcohol dehydrogenases.

P. Todd, A. Russell, K. Vincent, 2020, Bioorganic & medicinal chemistry.

Statin activation of skeletal ryanodine receptors (RyR1) is a class effect but separable from HMG‐CoA reductase inhibition

R. Sitsapesan, A. Russell, Maria Musgaard, 2022, British journal of pharmacology.

Disrupting Hypoxia-Induced Bicarbonate Transport Acidifies Tumor Cells and Suppresses Tumor Growth.

A. Harris, E. Bridges, A. McIntyre, 2016, Cancer research.

1.13 – Regenerative Medicine

G. Wynne, A. Russell, S. Davies, 2017 .