Qihua Zhu

发表

A Fluorogenic Trehalose Probe for Tracking Phagocytosed Mycobacterium tuberculosis.

C. Bertozzi, Tingting Dai, Jinghang Xie, 2020, Journal of the American Chemical Society.

Discovery of novel and potent PARP/PI3K dual inhibitors for the treatment of cancer.

Qihua Zhu, Ying Bai, Jie Jin, 2021, European journal of medicinal chemistry.

Novel tricyclic poly (ADP-ribose) polymerase-1/2 inhibitors with potent anticancer chemopotentiating activity: Design, synthesis and biological evaluation.

Qihua Zhu, Yungen Xu, Hui Li, 2016, Bioorganic & medicinal chemistry.

Identification of a novel selective inhibitor of mutant isocitrate dehydrogenase 1 at allosteric site by docking-based virtual screening

Yueqing Gu, A. Deimling, Qihua Zhu, 2016 .

Rational Design for Nitroreductase (NTR)-Responsive Proteolysis Targeting Chimeras (PROTACs) Selectively Targeting Tumor Tissues.

Zeyu Cai, Qihua Zhu, Y. Du, 2022, Journal of medicinal chemistry.

ED SUM: Triple-negative breast cancer is inhibited by depleting mitochondrial copper in mice.

S. Gambhir, D. Felsher, A. Giaccia, 2020, Nature Biotechnology.

Synthesis of Limonin Derivatives with Improved Anti-inflammatory and Analgesic Properties

Qihua Zhu, Guoqing Gong, Bin Hu, 2020 .

Discovery of novel brain-penetrant GluN2B NMDAR antagonists via pharmacophore-merging strategy as anti-stroke therapeutic agents.

Xiaodong Ma, Qihua Zhu, Mengqi Hu, 2021, European journal of medicinal chemistry.

Discovery of Potent and Novel Dual PARP/BRD4 Inhibitors for Efficient Treatment of Pancreatic Cancer.

Qihua Zhu, Yi Zou, Yun-Gen Xu, 2021, Journal of medicinal chemistry.

Synthesis and pharmacological evaluation of novel limonin derivatives as anti-inflammatory and analgesic agents with high water solubility.

Qihua Zhu, Guoqing Gong, Yungen Xu, 2014, Bioorganic & medicinal chemistry letters.

Discovery of novel IDO1 inhibitors targeting the protein's apo form through scaffold hopping from holo-IDO1 inhibitor.

Qihua Zhu, Yi Zou, Yungen Xu, 2021, Bioorganic & medicinal chemistry letters.

Design, synthesis and biological evaluation of novel 3H-imidazole [4,5-b] pyridine derivatives as selective mTOR inhibitors.

Qihua Zhu, Yiran Ge, Yungen Xu, 2017, Bioorganic & medicinal chemistry letters.

Discovery of the First Selective IDO2 Inhibitor As Novel Immunotherapeutic Avenues for Rheumatoid Arthritis.

Qihua Zhu, Yi Zou, Zhaoxing Chu, 2022, Journal of medicinal chemistry.

p-Toluenesulfonohydrazide as highly efficient initiator for direct C-H arylation of unactivated arenes.

Qihua Zhu, Dong-mei Zhang, Yungen Xu, 2014, Organic letters.

Design, Synthesis and Anti-Allergic Activity Evaluation of Aryl-Acetic Acid Derivatives

Qihua Zhu, Xue Bian, Yungen Xu, 2014 .

Optimization of 5-arylidene barbiturates as potent, selective, reversible LSD1 inhibitors for the treatment of acute promyelocytic leukemia.

F. Lan, Rongfeng Liu, Qihua Zhu, 2018, Bioorganic & medicinal chemistry.

Design, synthesis and biological evaluation of novel benzoxaborole derivatives as potent PDE4 inhibitors for topical treatment of atopic dermatitis.

Xiaodong Ma, Qihua Zhu, Wenfeng Ye, 2021, European journal of medicinal chemistry.

Synthesis and biological evaluation of novel laropiprant derivatives as potential anti-allergic agents

Qihua Zhu, Yungen Xu, Haipin Zhou, 2015, Medicinal Chemistry Research.

Discovery of the First Potent IDO1/IDO2 Dual Inhibitors: A Promising Strategy for Cancer Immunotherapy.

Qihua Zhu, Yi Zou, Zhaoxing Chu, 2021, Journal of medicinal chemistry.

Design, Synthesis and Biological Evaluation of Novel and Potent Protein Arginine Methyltransferases 5 Inhibitors for Cancer Therapy

Qihua Zhu, Yi Zou, Yixuan Tang, 2022, Molecules.

Direct Phase‐Transition Catalysed Monohalogenation of 8‐Amidoquinolines at C5 Position in Water

Qihua Zhu, Haiping Zhou, Xin He, 2021 .

Copper(I) and N-fluorobenzenesulfonimide-mediated direct regioselective halogenation of 8-amidoquinolines on the C5 position

Qihua Zhu, Xin He, Yungen Xu, 2017 .

Metal-Free Remote C-H Bond Amidation of 8-Amidoquinolines on the C5 Position under Mild Conditions.

Ziyue Xu, Qihua Zhu, Xin He, 2016, Organic letters.

Identification of novel allosteric inhibitors of mutant isocitrate dehydrogenase 1 by cross docking-based virtual screening.

A. von Deimling, Yueqing Gu, Qihua Zhu, 2017, Bioorganic & medicinal chemistry letters.

Design, synthesis and biological activity of 3-pyrazine-2-yl-oxazolidin-2-ones as novel, potent and selective inhibitors of mutant isocitrate dehydrogenase 1.

A. von Deimling, Yueqing Gu, Qihua Zhu, 2017, Bioorganic & medicinal chemistry.

A practical synthesis of amino limonin/deoxylimonin derivatives as effective mitigators against inflammation and nociception.

R. Chen, Qihua Zhu, Xueqing Han, 2020, RSC medicinal chemistry.

Discovery of deoxylimonin δ-lactam derivative with favorable anti-inflammation and antinociception efficacy from chemical modified limonin/deoxylimonin analogs.

Qihua Zhu, Chen Zhou, Xueqing Han, 2020, Bioorganic chemistry.

Discovery of novel limonin derivatives as potent anti-inflammatory and analgesic agents.

Qihua Zhu, Zhaoxing Chu, Jing Liu, 2018, Chinese journal of natural medicines.

Design, synthesis and biological evaluation of novel imidazo[4,5-c]pyridinecarboxamide derivatives as PARP-1 inhibitors.

Qihua Zhu, Zhaoxing Chu, Yungen Xu, 2013, Bioorganic & medicinal chemistry letters.

Design, synthesis and antithrombotic evaluation of novel dabigatran etexilate analogs, a new series of non-peptides thrombin inhibitors.

Qihua Zhu, Xueqing Han, Guoqing Gong, 2015, Bioorganic & medicinal chemistry.

Design, synthesis and antithrombotic evaluation of novel non-peptide thrombin inhibitors.

Qihua Zhu, Xiaoying Deng, Jing Liu, 2017, Bioorganic & medicinal chemistry.

Design, Synthesis, and Biological Evaluation of Dabigatran Etexilate Mimics, a Novel Class of Thrombin Inhibitors

Qihua Zhu, P. Dai, Guoqing Gong, 2015, Archiv der Pharmazie.

Discovery of Novel Dual Poly(ADP-ribose)polymerase (PARP) and Phosphoinositide 3-kinase (PI3K) Inhibitors as A Promising Strategy for Cancer Therapy.

Qihua Zhu, Zhaoxing Chu, Yiran Ge, 2019, Journal of medicinal chemistry.

Synthesis of 6-Substituted Phenanthridine Derivatives by Palladium-Catalysed Domino Suzuki–Miyaura/Aza-Michael Reactions

Qihua Zhu, Wei Yao, Yungen Xu, 2014 .

Transition Metal-Free C5 Tosyloxylation of 8-Aminoquinolines with Phenyliodine Bistrifluoroacetate and Substituted 1,2-Disulfonyl Hydrazides

Qihua Zhu, Xin He, Yuyan Li, 2019, European Journal of Organic Chemistry.

Palladium‐Catalyzed Tandem Reactions of β‐(2‐Bromophenyl)‐α,β‐Unsaturated Carbonyl Compounds with 2‐Hydroxyphenylboronic Acid: A New Route to Benzo[c]chromenes

Qihua Zhu, Yungen Xu, Xuyan Wang, 2012 .

Efficient Palladium-Catalyzed C-H Fluorination of C(sp3)-H Bonds: Synthesis of β-Fluorinated Carboxylic Acids.

Qihua Zhu, Yungen Xu, Xueyan Wang, 2015, Organic letters.

Palladium‐catalyzed Synthesis of Novel O‐Heterocycles by Domino Suzuki Coupling‐Michael Addition Reaction

Qihua Zhu, Jingjie Feng, Yuyan Li, 2016 .

Design, synthesis and biological evaluation of N-hydroxy-aminobenzyloxyarylamide analogues as novel selective κ opioid receptor antagonists.

Qihua Zhu, Kewen Peng, Yungen Xu, 2020, Bioorganic & medicinal chemistry letters.

Design, synthesis and biological evaluation of aminobenzyloxyarylamide derivatives as selective κ opioid receptor antagonists.

Qihua Zhu, Yungen Xu, Yu Bao, 2017, European journal of medicinal chemistry.

Design, synthesis and biological evaluation of novel molecules as potent PARP-1 inhibitors.

Qihua Zhu, Yiran Ge, Yungen Xu, 2021, Bioorganic & medicinal chemistry letters.

Targeting VEGF-neuropilin interactions: a promising antitumor strategy.

Bin Hu, Qihua Zhu, Yungen Xu, 2019, Drug discovery today.

Discovery of the Potent and Highly Selective PARP7 Inhibitor as a Novel Immunotherapeutic Agent for Tumors.

Qihua Zhu, H. Hao, Yi Zou, 2022, Journal of medicinal chemistry.

Discovery of potent, orally bioavailable ERK1/2 inhibitors with isoindolin-1-one structure by structure-based drug design.

Qihua Zhu, Ying Bai, Yungen Xu, 2019, European journal of medicinal chemistry.

Mitochondrial copper depletion suppresses triple-negative breast cancer in mice

S. Gambhir, D. Felsher, A. Giaccia, 2020, Nature Biotechnology.

ED SUM: Triple-negative breast cancer is inhibited by depleting mitochondrial copper in mice.

S. Gambhir, D. Felsher, A. Giaccia, 2020, Nature biotechnology.

Discovery of novel potent covalent inhibitor-based EGFR degrader with excellent in vivo efficacy.

Qihua Zhu, Jianwei Cui, Yungen Xu, 2022, Bioorganic chemistry.

Identification of New Inhibitors of Mutant Isocitrate Dehydrogenase 2 through Molecular Similarity-based Virtual Screening

A. Deimling, Qihua Zhu, S. Pusch, 2019, Letters in Drug Design & Discovery.

Discovery of Novel Small-Molecule Inhibitors of PD-1/PD-L1 Interaction via Structural Simplification Strategy

Qihua Zhu, Yi Zou, Yungen Xu, 2021, Molecules.

Discovery and SAR study of 2-(1-propylpiperidin-4-yl)-3H-imidazo[4,5-c]pyridine-7-carboxamide: A potent inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1) for the treatment of cancer.

Qihua Zhu, Xiaorong He, Guoqing Gong, 2015, Bioorganic & medicinal chemistry.

Discovery of novel PARP/PI3K dual inhibitors with high efficiency against BRCA-proficient triple negative breast cancer.

Qihua Zhu, Yiran Ge, Yungen Xu, 2020, European journal of medicinal chemistry.

Recent advances in inhibitors of sirtuin1/2: an update and perspective.

Qihua Zhu, Tianfang Ma, X. Zha, 2018, Future medicinal chemistry.

Novel Opioid Receptor Agonists with Reduced Morphine-like Side Effects.

Qihua Zhu, X. Zha, Yungen Xu, 2018, Mini-Reviews in Medical Chemistry.

Rational design, synthesis and biological evaluation of dual PARP-1/2 and TNKS1/2 inhibitors for cancer therapy.

Qiang Xu, Qihua Zhu, Huanhuan Wu, 2022, European journal of medicinal chemistry.

Efficient Palladium-Catalyzed C—H Fluorination of C(sp3)—H Bonds: Synthesis of β-Fluorinated Carboxylic Acids.

Qihua Zhu, Yungen Xu, Xueyan Wang, 2015 .

Discovery of Novel Dual Bruton’s Tyrosine Kinase (BTK) and Janus Kinase 3 (JAK3) Inhibitors as A Promising Strategy for Rheumatoid Arthritis

Haifeng Zhang, Qihua Zhu, Ming-Fu Cheng, 2023, Bioorganic & Medicinal Chemistry.

Discovery of Novel Dual Extracellular Regulated Protein Kinases (ERK) and Phosphoinositide 3-Kinase (PI3K) Inhibitors as a Promising Strategy for Cancer Therapy

Qihua Zhu, Jinjin Sun, Yungen Xu, 2020, Molecules.

Design, synthesis and biological evaluation of novel 5-fluoro-1H-benzimidazole-4-carboxamide derivatives as potent PARP-1 inhibitors.

Qihua Zhu, Yuyan Li, Yungen Xu, 2016, Bioorganic & medicinal chemistry letters.

Discovery of novel nonpeptide small-molecule NRP1 antagonists: Virtual screening, molecular simulation and structural modification.

Huiyong Sun, Yu Li, Qihua Zhu, 2019, Bioorganic & medicinal chemistry.

Design, synthesis and biological evaluation of novel desloratadine derivatives with anti-inflammatory and H1 antagonize activities.

Qihua Zhu, Zhaoxing Chu, Yan Zhao, 2019, Bioorganic & medicinal chemistry letters.

Novel Synthesis of Antiobesity Drug Lorcaserin Hydrochloride

P. Wei, Qihua Zhu, Xue Bian, 2015 .

Synthesis and Anti-inflammatory Evaluation of Novel 1,2,3-Triazole Derivatives

Qihua Zhu, Zeren Sun, Yi Zou, 2023, Chinese Journal of Organic Chemistry.

Synthesis and biological evaluation of novel laropiprant derivatives as potential anti-allergic agents

Qihua Zhu, Yungen Xu, Haipin Zhou, 2015, Medicinal Chemistry Research.

p-Toluenesulfonohydrazide as highly efficient initiator for direct C-H arylation of unactivated arenes.

Qihua Zhu, Dong-mei Zhang, Yungen Xu, 2014, Organic letters.

Design, synthesis and antithrombotic evaluation of novel non-peptide thrombin inhibitors.

Qihua Zhu, Xiaoying Deng, Jing Liu, 2017, Bioorganic & medicinal chemistry.

Discovery of Highly Selective PARP7 Inhibitors with a Novel Scaffold for Cancer Immunotherapy.

Qihua Zhu, Yi Zou, Wenbo Xu, 2023, Journal of medicinal chemistry.

Discovery of novel EGFR-PROTACs capable of degradation of multiple EGFR-mutated proteins.

Qihua Zhu, Yungen Xu, Chengxia Shu, 2024, European journal of medicinal chemistry.

Discovery of highly potent PARP7 inhibitors for cancer immunotherapy

Qihua Zhu, Beibei Liu, Xiaolin Zhao, 2024, Bioorganic Chemistry.