K. Douglas

发表

Molecular dynamics study of chemically engineered green fluorescent protein mutants: Comparison of intramolecular fluorescence resonance energy transfer rate

Felicity L. Mitchell, F. Frank, Gabriel E. Marks, 2009, Proteins.

Quantum dot FRET biosensors that respond to pH, to proteolytic or nucleolytic cleavage, to DNA synthesis, or to a multiplexing combination.

Miho Suzuki, K. Douglas, Koji Suzuki, 2008, Journal of the American Chemical Society.

Chemical reactivity of some isothiazolone biocides.

K. Douglas, P. Collier, A. Ramsey, 1990, The Journal of applied bacteriology.

The glutamyl binding site of trypanothione reductase from Crithidia fasciculata: enzyme kinetic properties of gamma-glutamyl-modified substrate analogues.

A. Fairlamb, K. Douglas, A. el-Waer, 1993, Biochimica et biophysica acta.

Identification of a novel class of inhibitor of human and Escherichia coli thymidine phosphorylase by in silico screening.

M Jaffar, I. Stratford, M. Jaffar, 2003, Bioorganic & medicinal chemistry letters.

Hoechst 33258 and its complex with the oligonucleotide d(CGCGAATTCGCG) 2: 1H NMR assignments and dynamics

G. Morris, K. Douglas, J. Parkinson, 1992 .

Minor-groove recognition of the self-complementary duplex d(CGCGAATTCGCG)2 by Hoechst 33258: a high-field NMR study.

K. Douglas, J. Parkinson, J. Barber, 1990, Biochemistry.

The thymidylate synthesis cycle and anticancer drugs

K. Douglas, 1987, Medicinal research reviews.

Self-assembly of heterobimetallic d-f hybrid complexes: sensitization of lanthanide luminescence by d-block metal-to-ligand charge-transfer excited states.

K. Douglas, S. Faulkner, Xuan Yu, 2004, Journal of the American Chemical Society.

Synthesis and enzymology of modifiedN-benzyloxycarbonyl-L-cysteinylglycyl-3,3-dimethylaminopropylamide disulphides as alternative substrates for trypanothione reductase fromTrypanosoma crud: Part 3

A. Fairlamb, K. Douglas, J. McKie, 2005, Amino Acids.

Peptoid inhibition of trypanothione reductase as a potential antitrypanosomal and antileishmanial drug lead

A. Fairlamb, C. Chan, K. Douglas, 2002, Amino Acids.

Specific peptide inhibitors of trypanothione reductase with backbone structures unrelated to that of substrate: potential rational drug design lead frameworks

A. Fairlamb, C. Chan, K. Douglas, 2001, Amino Acids.

Rational design of selective ligands for trypanothione reductase from Trypanosoma cruzi. Structural effects on the inhibition by dibenzazepines based on imipramine.

A. Fairlamb, K. Douglas, H. Yin, 1997, Journal of enzyme inhibition.

Synthesis of N-benzyloxycarbonyl-L-cysteinylglycine 3-dimethylaminopropylamide disulfide: a cheap and convenient new assay for trypanothione reductase.

A. Fairlamb, K. Douglas, A. el-Waer, 1991, Analytical biochemistry.

Molecular design of DNA-directed ligands with specific interactions: solution NMR studies of the interaction of a m-hydroxy analogue of Hoechst 33258 with d(CGCGAATTCGCG)2.

K. Douglas, J. Parkinson, J. McKie, 1994, Biochemistry.

Unique binding site for bis-benzimidazoles on transfer RNA

K. Douglas, S. Ebrahimi, A. Wilton, 1997 .

Rational drug design approach for overcoming drug resistance: application to pyrimethamine resistance in malaria.

M Read, J. E. Hyde, W. Sirawaraporn, 1998, Journal of medicinal chemistry.

Pyrimethamine analogs as strong inhibitors of double and quadruple mutants of dihydrofolate reductase in human malaria parasites.

W. Sirawaraporn, K. Douglas, R. Sirawaraporn, 2003, Organic & biomolecular chemistry.

Use of transferred nuclear-Overhauser-effect spectroscopy to measure the bound conformation of a disulphide-replaced analogue of glutathione disulphide as an inhibitor of yeast glutathione reductase.

K. Douglas, K. Embrey, J. McKie, 1994, European journal of biochemistry.

Structure of photoreactive binary system of oligonucleotide conjugates assembled on the target nucleotide sequence.

V. Vlassov, K. Douglas, E. Bichenkova, 1999, Journal of biomolecular structure & dynamics.

Photo-induced covalent labelling of malate dehydrogenase by quercetin.

K. Douglas, A. Seddon, 1981, Biochemical and biophysical research communications.

Interactions of small ligands with Busycon canaliculatum and Limulus polyphemus hemocyanins as studied by ultraviolet spectrophotometry and 1H and 19F nuclear magnetic resonance.

K. Douglas, C. Chang, N. Li, 1978, Biochemistry.

Mechanistic studies of carboxypeptidase Y. Kinetic detection of an acyl-enzyme intermediate in trimethylacetate esterase action.

E. Kaiser, K. Douglas, Y. Nakagawa, 1976, Journal of the American Chemical Society.

Rational design of peptide-based inhibitors of trypanothione reductase as potential antitrypanosomal drugs

A. Fairlamb, K. Douglas, J. McKie, 1994, Amino Acids.

Photoaffinity labelling by S-(p-azidophenacyl)-glutathione of glyoxalase II and glutathione S-transferase.

K. Douglas, M. Bunni, A. Seddon, 1980, Biochemical and biophysical research communications.

Photoaffinity labelling of the active site of the rat glutathione transferases 3-3 and 1-1 and human glutathione transferase A1-1.

B. Mannervik, K. Douglas, B. Ketterer, 1994, The Biochemical journal.

The potential role of glycine-160 of human O6-alkylguanine-DNA alkyltransferase in reaction with O6-benzylguanine as determined by site-directed mutagenesis and molecular modelling comparisons.

J. Wibley, K. Douglas, P. Moody, 1997, Biochimica et biophysica acta.

Vanadate as a Futile, Superoxide Ion-producing Substrate of Trypanothione Reductase from Trypanosoma cruzi

M. O. Khan, K. Douglas, S. Parveen, 2005 .

Fluphenazine photoaffinity labelling of binding sites for phenothiazine inhibitors of trypanothione reductase

A. Fairlamb, S. Gaskell, K. Douglas, 1996 .

Synthesis of substrate analogues for trypanothione reductase.

K. Douglas, A. el-Waer, T. Benson, 2009, International journal of peptide and protein research.

Structural requirements of double and single stranded DNA substrates and inhibitors, including a photoaffinity label, of Fpg protein from Escherichia coli.

K. Douglas, G. Nevinsky, A. Ishchenko, 1999, Journal of biomolecular structure & dynamics.

Binding Studies of Bile Acids using the Native Fluorescence of the Tryptophan Residue Of Bax Protein

C. Steer, K. Douglas, C. Rodrigues, 2006, Bioscience reports.

Recognition of damaged DNA by Escherichia coli Fpg protein: insights from structural and kinetic data.

K. Douglas, G. Nevinsky, A. Ishchenko, 2003, Mutation research.

Development of novel DNA cleavage systems based on copper

K. Douglas, 1996 .

Aminoimidazolylmethyluracil analogues as potent inhibitors of thymidine phosphorylase and their bioreductive nitroimidazolyl prodrugs.

S. Barry, S. Ashton, I. Stratford, 2005, Journal of medicinal chemistry.

Structural studies by high-field NMR spectroscopy of a binary-addressed complementary oligonucleotide system juxtaposing pyrene and perfluoro-azide units.

D. Marks, V. Vlassov, K. Douglas, 1997, Journal of biomolecular structure & dynamics.

BINDING OF A PORPHYRIN CONJUGATE OF HOECHST 33258 TO DNA. II. NMR SPECTROSCOPIC STUDIES DETECT MULTIPLE BINDING MODES TO A 12-MER NONSELF-COMPLEMENTARY DUPLEX DNA

K. Douglas, E. Bichenkova, S. Frau, 2001, Nucleosides, nucleotides & nucleic acids.

BINDING OF A PORPHYRIN CONJUGATE OF HOECHST 33258 TO DNA. I. UV-VISIBLE AND MELTING STUDIES DETECT MULTIPLE BINDING MODES TO A 12-MER NONSELF-COMPLEMENTARY DUPLEX

K. Douglas, O. Fedorova, E. Bichenkova, 2001, Nucleosides, nucleotides & nucleic acids.

Stopped-flow kinetic studies of the interaction between Escherichia coli Fpg protein and DNA substrates.

K. Douglas, G. Nevinsky, A. Ishchenko, 2002, Biochemistry.

SNP Detection for Cytochrome P450 Alleles by Target-assembled Tandem Oligonucleotide Systems Based on Exciplexes

K. Douglas, E. Bichenkova, A. Gbaj, 2008, Journal of biomolecular structure & dynamics.

Alteration of enzyme specifity and catalysis

K. Douglas, 1992, Current Biology.

Apparent sequence preference in cleavage of linear B-DNA by the Cu(II):thiol system.

K. Douglas, D. John, 1989, Biochemical and biophysical research communications.

A photoaffinity label derivative of glutathione and its inhibition of glyoxalase I

K. Douglas, A. Seddon, 1980, FEBS letters.

Thymidine phosphorylase from Escherichia coli: Tight-binding inhibitors as enzyme active-site titrants

M. Jaffar, K. Douglas, S. Freeman, 2006, Journal of enzyme inhibition and medicinal chemistry.

Incorporation of basic side chains into cryptolepine scaffold: structure-antimalarial activity relationships and mechanistic studies.

J. Gut, P. Rosenthal, M. Mota, 2011, Journal of medicinal chemistry.

Mechanism of action of glutathione-dependent enzymes.

K. Douglas, Kenneth T. Douglas, 2006, Advances in enzymology and related areas of molecular biology.

Chapter 4 Aspects of kinetic techniques in enzymology

Michael T. Wilson, K. Douglas, 1984 .

ANTICANCER DRUGS. DNA AS A TARGET

K. Douglas, 1985 .

Caspase-3 sensitive signaling in vivo in apoptotic HeLa cells by chemically engineered intramolecular fluorescence resonance energy transfer mutants of green fluorescent protein.

I. Sakata, Miho Suzuki, K. Douglas, 2005, Biochemical and biophysical research communications.

Glutathione derivatives as inhibitors of glutaredoxin and ribonucleotides reductase from Escherichia coli

A. Holmgren, K. Douglas, J. Höög, 1982, FEBS letters.

Single-strand cleavage of DNA by Cu(II) and thiols: a powerful chemical DNA-cleaving system.

K. Douglas, K T Douglas, C J Reed, 1989, Biochemical and biophysical research communications.

Chemical cleavage of plasmid DNA by glutathione in the presence of Cu(II) ions. The Cu(II)-thiol system for DNA strand scission.

K. Douglas, K T Douglas, C J Reed, 1991, The Biochemical journal.

Elimination-addition pathways for thiol esters

K. Douglas, 1986 .

Potential tumor-selective nitroimidazolylmethyluracil prodrug derivatives: inhibitors of the angiogenic enzyme thymidine phosphorylase.

I. Stratford, M. Jaffar, K. Douglas, 2003, Journal of medicinal chemistry.

Discovery of novel inhibitors of Trypanosoma cruzi trans-sialidase from in silico screening.

Pedro M Alzari, Richard A Bryce, Paul N. Mortenson, 2009, Bioorganic & medicinal chemistry letters.

Differences in the cleavage of DNA by bleomycin under light (300-350 nm) and dark conditions.

R. Davies, K. Douglas, S. Minter, 1982, Cancer letters.

Improved efficiency and selectivity in peptide synthesis: Use of triethylsilane as a carbocation scavenger in deprotection of t-butyl esters and t-butoxycarbonyl-protected sites

K. Douglas, T. Benson, A. Mehta, 1992 .

Chemical Basis of the Action of Glyoxalase I, an Anticancer Target Enzyme

K. Douglas, S. Shinkai, 1985 .

Photo-labelling of glutaredoxin from Escherichia coli.

A. Holmgren, K. Douglas, J. Höög, 1982, Biochemical and biophysical research communications.

Ferrocenopapain, an organometallic protein formed by site-specific inactivation of papain using chloroacetylferrocene.

O. Ejim, K. Douglas, K. Taylor, 1992, Journal of enzyme inhibition.

A NOVEL CONVENIENT ROUTE TO THE NATURALLY OCCURRING 3-OXOACYL-L-HOMOSERINELACTONES AND RELATED BACTERIAL AUTOINDUCERS

K. Douglas, P. Gilbert, M. Dekhane, 1996 .

The 1,4-naphthoquinone scaffold in the design of cysteine protease inhibitors.

M. Jaffar, K. Douglas, R. Guedes, 2007, Bioorganic & medicinal chemistry.

Inhibition of glyoxalase I: a possible transition‐state analogue inhibitor approach to potential antineoplastic agents?

K. Douglas, I. N. Nadvi, Iffat N. Nadvi, 1979, FEBS letters.

Trapping of ractive intermediates in enzymology. Exogenous flaviin reduction during catalytic turnover of substrate by gluyoxalase I

K. Douglas, S. Shinkai, K. Ueda, 1985 .

Chemical modification of tyrosine residues in glyoxalase I from yeast and human erythrocytes.

K. Douglas, S. Carrington, D. Fetherbe, 1989, The International journal of biochemistry.

Inhibition of mammalian glyoxalase I (lactoylglutathione lyase) by N-acylated S-blocked glutathione derivatives as a probe for the role of the N-site of glutathione in glyoxalase I mechanism.

K. Douglas, A. Al-Timari, 1986, Biochimica et biophysica acta.

Yeast glyoxalase I. Circular dichroic spectra and pH effects.

K. Douglas, Y. Nakagawa, A. Seddon, 1986, The International journal of biochemistry.

Partial transition-state inhibitors of glyoxalase I from human erythrocytes, yeast and rat liver.

K. Douglas, A. Seddon, D. Gohel, 1985, Biochimica et biophysica acta.

pH Dependence of the inhibition of yeast glyoxalase I by porphyrins.

K. Douglas, J. Sharif, 1983, Biochimica et biophysica acta.

Rational inhibitor design, synthesis and NMR spectroscopic study by transferred nuclear overhauser spectroscopy of novel inhibitors of cinnamyl alcohol dehydrogenase, a critical enzyme in lignification.

J. Grima-Pettenati, K. Douglas, K. Embrey, 1999, Journal of enzyme inhibition.

Antitrypanosomal, antileishmanial, and antimalarial activities of quaternary arylalkylammonium 2-amino-4-chlorophenyl phenyl sulfides, a new class of trypanothione reductase inhibitor, and of N-acyl derivatives of 2-amino-4-chlorophenyl phenyl sulfide.

V. Yardley, S. Croft, S. E. Austin, 2005, Journal of medicinal chemistry.

An unusual elimination–addition (keten-mediated)aminolysis pathway for malonic S-thioesters, including S-malonyl coenzyme A

K. Douglas, Gregory R. Rullo, Manoochehr Alborz, 1982 .

Alkaline hydrolysis and aminolysis of N-acyl-areneiminosulphonate esters

K. Douglas, F. M. Said, 1986 .

Hydrolysis of aryl N-methylaminosulphonates: evidence consistent with an E1cB mechanism

K. Douglas, A. Williams, 1974 .

Photolabelling of dopamine-β-hydroxylase by bleomycin

K. Douglas, H. A. Ratwatte, 1983 .

Exciplex fluorescence emission from simple organic intramolecular constructs in non-polar and highly polar media as model systems for DNA-assembled exciplex detectors.

P. Bonnet, K. Douglas, R. Bryce, 2006, Organic & biomolecular chemistry.

DNA-mounted self-assembly: new approaches for genomic analysis and SNP detection.

K. Douglas, Xuan Yu, E. Bichenkova, 2011, Biochimica et biophysica acta.

ACID-CATALYSED HYDROLYSIS AND ALCOHOLYSIS OF 4-NITROPHENYL-N-ACETYL-PHENYLIMINOSULPHONATE

J. Hallett, K. Douglas, F. M. Said, 1988 .

Alkaline Hydrolysis and Aminolysis of N-Acyl-areneiminosulphonate Esters.

K. Douglas, F. M. Said, 1987 .

Design, synthesis and enzymatic evaluation of 6‐bridged imidazolyluracil derivatives as inhibitors of human thymidine phosphorylase

I. Stratford, M. Jaffar, K. Douglas, 2007, The Journal of pharmacy and pharmacology.

Thallium in biochemistry.

K. Douglas, K T Douglas, M. Bunni, 1990, The International journal of biochemistry.

Phenothiazine inhibitors of trypanothione reductase as potential antitrypanosomal and antileishmanial drugs.

A. Fairlamb, V. Yardley, S. Croft, 1998, Journal of medicinal chemistry.

Interactions of Sulfur-Containing Ligands with Arthropod and Molluscan Hemocyanins

K. Douglas, N. Li, I. -. Lee, 1977 .

Target-assembled tandem oligonucleotide systems based on exciplexes for detecting DNA mismatches and single nucleotide polymorphisms.

K. Douglas, E. Bichenkova, A. Sardarian, 2005, Biochemical and biophysical research communications.

An exciplex-based, target-assembled fluorescence system with inherently low background to probe for specific nucleic acid sequences.

K. Douglas, E. Bichenkova, A. Sardarian, 2005, Assay and drug development technologies.

Unusually facile syntheses of [RuII(bpy)3]2+ (bpy = 2,2′-bipyridine) and [RuII(phen)3]2+ (phen = 1,10-phenanthroline)

K. Douglas, B. Coe, A. Sardarian, 2003 .

Rational drug design in parasitology: trans-sialidase as a case study for Chagas disease.

K. Douglas, R. Bryce, J. Neres, 2008, Drug discovery today.

Benzoic acid and pyridine derivatives as inhibitors of Trypanosoma cruzi trans-sialidase.

P. Alzari, P. Bonnet, K. Douglas, 2007, Bioorganic & medicinal chemistry.

Continuous fluorimetric assay for high-throughput screening of inhibitors of trans-sialidase from Trypanosoma cruzi.

P. Alzari, K. Douglas, A. Buschiazzo, 2006, Analytical biochemistry.

Synthesis and enzymatic evaluation of xanthine oxidase-activated prodrugs based on inhibitors of thymidine phosphorylase.

E. Chinje, I. Stratford, K. Douglas, 2004, Bioorganic & medicinal chemistry letters.

Strong, Specific, Reversible Binding Ligands for Transfer RNA: Comparison by Fluoresence and NMR Spectroscopies with Distamycin Binding for a New Structural Class of Ligand

D. Marks, K. Douglas, E. Bichenkova, 1998 .

Organothallium(III) reagents for modification of biomacromolecules: interaction of thallium derivatives with transfer RNA.

K. Douglas, S. R. Baindur, 1987, Biochimica et biophysica acta.

Towards Chemical Control of Gene Expression: Copper (II) and Thiols, Including Glutathione, are Powerful Reagents for Cleavage of DNA

C. J. Reed, K. Douglas, D. John, 2011 .

Sequence-specific artificial ribonucleases. I. Bis-imidazole-containing oligonucleotide conjugates prepared using precursor-based strategy.

V. Vlassov, N. Polushin, K. Douglas, 2004, Nucleic acids research.

Refined high-field NMR solution structure of a binary-addressed pyrene/perfluoro-azide complementary DNA oligonucleotide system shows extensive distortion in the central nick region.

D. Marks, V. Vlassov, K. Douglas, 1999, Journal of biomolecular structure & dynamics.

Inhibitors of glutathione reductase as potential antimalarial drugs. Kinetic cooperativity and effect of dimethyl sulphoxide on inhibition kinetics.

K. Douglas, J. Vale, J. McKie, 1998, Journal of enzyme inhibition.

D. Marks, I. Stratford, M. Jaffar, 1999, Anti-cancer drug design.

Thermodynamic, kinetic and structural basis for recognition and repair of abasic sites in DNA by apurinic/apyrimidinic endonuclease from human placenta.

K. Douglas, G. Nevinsky, A. Ishchenko, 2004, Nucleic acids research.

Isolation and partial characterization of murine O6‐alkyiguanine‐DNA‐alkyltransferase: Comparative sequence and structural properties

M. Santibanez-Koref, G. Margison, C. Fan, 1992, Molecular carcinogenesis.

Organothallium(III) reagents for modification of biomacromolecules: irreversible labelling of phosphoglycerate kinase from rabbit muscle.

A. Drake, K. Douglas, M. Bunni, 1987, Biochimica et biophysica acta.

Arylthallium(III) reagents for protein modification. Inhibition of lactate dehydrogenase from various sources by o-carboxyphenylthallium(III) bistrifluoroacetate.

K. Douglas, M. Bunni, 1984, The Biochemical journal.

Increased stability and lifetime of the complex formed between DNA and meta-phenyl-substituted Hoechst dyes as studied by fluorescence titrations and stopped-flow kinetics.

R. Clegg, K. Douglas, F. Loontiens, 2001, Journal of molecular biology.

BINDING OF A DESMETALLO-PORPHYRIN CONJUGATE OF HOECHST 33258 TO DNA. III. STRONG BINDING TO SINGLE-STRAND OLIGONUCLEOTIDES

K. Douglas, O. Fedorova, E. Bichenkova, 2001, Nucleosides, nucleotides & nucleic acids.

Synthesis and cytotoxicity of shikimate analogues. Structure:activity studies based on 1-crotonyloxymethyl-3R,4R,5R-trihydroxycyclohex-2-enone.

J. Double, M. Bibby, K. Douglas, 1992, Anti-cancer drug design.

Elimination-addition mechanisms of acyl transfer reactions

K. Douglas, Andrew C. Williams, 1975 .

Crystal Structure of the Catalytic Domain of the Mitotic Checkpoint Kinase Mps1 in Complex with SP600125*

Leonard M. G. Chavas, Lydia Tabernero, Kenneth T. Douglas, 2008, Journal of Biological Chemistry.

Molecular probes: insights into design and analysis from computational and physical chemistry.

Felicity L. Mitchell, Gabriel E. Marks, K. Douglas, 2008, Biochemical Society transactions.

Target-assembled exciplexes based on Scorpion oligonucleotides.

D. Whitcombe, K. Douglas, E. Bichenkova, 2008, Bioscience reports.

* Manuscript Target-assembled exciplexes based on Scorpion oligonucleotides

D. Whitcombe, K. Douglas, A. Gbaj, 2007 .

Molecular Basis of Action of HyBeacon™ Fluorogenic Probes: A Spectroscopic and Molecular Dynamics Study

K. Douglas, R. Bryce, E. Bichenkova, 2005, Journal of biomolecular structure & dynamics.

Target-assembled ExciProbes: Application to DNA Detection at the Level of PCR Product and Plasmid DNA

M. C. Rogert Bacigalupo, K. Douglas, E. Bichenkova, 2007, Journal of biomolecular structure & dynamics.

Elimination-addition mechanisms of acyl group transfer: hydrolysis and aminolysis of aryl phenylmethanesulfonates

K. Douglas, Andrew C. Williams, J. Loran, 1977 .

E1cB mechanisms. Part II. Base hydrolysis of substituted phenyl phosphorodiamidates

K. Douglas, A. Williams, 1972 .

Kinetics of substrate recognition and cleavage by human 8-oxoguanine-DNA glycosylase

K. Douglas, G. Nevinsky, V. Koval, 2005, Nucleic acids research.

: Approaches to Design and Synthesis of Antiparasitic Drugs, by Satyavan Sharma (edited by Nitya Anand)

K. Douglas, 1999 .

Oral Absorption of D-Oligopeptides in Rats via the Paracellular Route

M. Rowland, A. Collett, G. Warhurst, 1996, Pharmaceutical Research.

Biophysical and X-ray crystallographic analysis of Mps1 kinase inhibitor complexes.

L. Tabernero, P. Eyers, M. Chu, 2010, Biochemistry.

Evidence for gene duplication forming similar binding folds for NAD(P)H and FAD in pyridine nucleotide‐dependent flavoenzymes

K. Douglas, J. McKie, 1991, FEBS letters.

Rational drug design in parasitology.

K. Douglas, 1994, Parasitology today.

A molecular model for cinnamyl alcohol dehydrogenase, a plant aromatic alcohol dehydrogenase involved in lignification.

J. Grima-Pettenati, K. Douglas, A. Boudet, 1993, Biochimica et biophysica acta.

E1cB mechanisms. Part IV. Base hydrolysis of substituted phenyl phosphoro- and phosphorothio-diamidates

K. Douglas, A. Williams, 1973 .

Kinetic Conformational Analysis of Human 8-Oxoguanine-DNA Glycosylase*

K. Douglas, G. Nevinsky, V. Koval, 2007, Journal of Biological Chemistry.

Pre-steady-state kinetic study of substrate specificity of Escherichia coli formamidopyrimidine--DNA glycosylase.

K. Douglas, G. Nevinsky, V. Koval, 2007, Biochemistry.

Pre-steady-state kinetics shows differences in processing of various DNA lesions by Escherichia coli formamidopyrimidine-DNA glycosylase.

K. Douglas, G. Nevinsky, A. Ishchenko, 2004, Nucleic acids research.

Electrochemical Reduction in the Synthesis of Catechol-Derived Peptides as Potential Metal Chelators and Enzyme I nhibitors

K. Douglas, C. D’Silva, 1983 .

A Chemically Modified Green-Fluorescent Protein that Responds to Cleavage of an Engineered Disulphide Bond by Fluorescence Resonance Energy Transfer (FRET)-Based Changes

Wei Zhang, Miho Suzuki, K. Douglas, 2005 .

Protease-sensitive signalling by chemically engineered intramolecular fluorescent resonance energy transfer mutants of green fluorescent protein.

Miho Suzuki, K. Douglas, Y. Husimi, 2004, Biochimica et biophysica acta.

Intramolecular Fluorescent Resonance Energy Transfer (FRET) by BODIPY Chemical Modification of Cysteine-engineered Mutants of Green Fluorescent Protein

Miho Suzuki, K. Douglas, Y. Husimi, 2003 .

Multiple forms of carboxypeptidase Y from Saccharomyces cerevisiae. Kinetic demonstration of effects of carbohydrate residues on the catalytic mechanism of a glycoenzyme.

E. Kaiser, K. Douglas, Y. Nakagawa, 1978, The Journal of biological chemistry.

Improved Efficiency and Selectivity in Peptide Synthesis: Use of Triethylsilane as a Carbocation Scavenger in Deprotection of tert‐ Butyl Esters and tert‐Butoxycarbonyl‐Protected Sites.

K. Douglas, T. Benson, A. Mehta, 1993 .

Multipurpose indicator in cells using intramolecular FRET between GFP and chemical compounds

Yoichiro Ito, Miho Suzuki, Yuzuru Husimi, 2003, SPIE BiOS.

Stereoselective, strong inhibition of ribonucleotide reductase from E. coli by cisplatin.

K. Douglas, S. Smith, 1989, Biochemical and biophysical research communications.

Photoaffinity labelling of macrophages and B-lymphocytes using 125I-labelled aryl-azide derivatives of muramyldipeptide.

K. Douglas, J. Tenu, J. Petit, 1989, International journal of immunopharmacology.

Malonylcoenzyme A models. Part 2. The methylene deprotonation step of the E1cB acyl transfer of malonic acid thiolmonoesters

K. Douglas, Gregory R. Rullo, Manoochehr Alborz, 1982 .

Effect of an aromatic ester conjugate base on E1cB ester hydrolysis. Alkaline hydrolysis of fluorene-9-carboxylate esters

K. Douglas, Manoochehr Alborz, 1982 .

Use of an additional hydrophobic binding site, the Z site, in the rational drug design of a new class of stronger trypanothione reductase inhibitor, quaternary alkylammonium phenothiazines

D. Marks, V. Yardley, S. Croft, 2000 .

Use of an additional hydrophobic binding site, the Z site, in the rational drug design of a new class of stronger trypanothione reductase inhibitor, quaternary alkylammonium phenothiazines.

D. Marks, V. Yardley, S. Croft, 2000, Journal of medicinal chemistry.

Porphyrins and porphines bind strongly and specifically to tRNA, precursor tRNA and to M1 RNA and inhibit the ribonuclease P ribozyme reaction.

K. Douglas, Y. Kikuchi, E. Bichenkova, 2005, Biochimica et biophysica acta.

Nucleophilic versus general base catalysis in phosphyl (PV) group transfer: application to α-chymotrypsin action

K. Douglas, A. Williams, 1976 .

Inhibition by glutathione derivatives of bovine liver glyoxalase II (hydroxyacylglutathione hydrolase) as a probe of the N- and S-sites for substrate binding.

K. Douglas, A. Al-Timari, 1986, Biochimica et biophysica acta.

Studies of the interaction of a meta-hydroxy analogue of hoechst 33258 with DNA by melting temperature, footprinting and high-resolution 1H NMR spectroscopy

K. Douglas, J. Parkinson, J. Barber, 1992 .

Sequence-dependent reactivity of linear DNA to chemical cleavage by Cu(II):thiol combinations including cysteine or glutathione.

K. Douglas, D C John, K T Douglas, 1993, The Biochemical journal.

Alteration of enzyme specificity and catalysis.

K. Douglas, 1992, Current opinion in biotechnology.

Solution chemistry and Mössbauer study of iron(II) and iron(III) complexes from gallocyanine

K. Douglas, J. Silver, B. Howlin, 1984 .

Leaving group effects in thiolester hydrolysis. Part 2. On the possibility of an elimination–addition (keten) mediated pathway in S-acetylcoenzyme a basic hydrolysis and acetyl transfer

K. Douglas, N. F. Yaggi, C. M. Mervis, 1981 .

Synthetic inhibitors of the processing of pretransfer RNA by the ribonuclease P ribozyme: enzyme inhibitors which act by binding to substrate.

K. Douglas, Y. Sugiura, Y. Kikuchi, 2001, Biochemistry.

Rationally designed selective inhibitors of trypanothione reductase. Phenothiazines and related tricyclics as lead structures.

A. Fairlamb, K. Douglas, J. McKie, 1992, The Biochemical journal.

An E2 mechanism for the alkaline hydrolysis of tolune-α-sulphonate esters of acidic phenols

K. Douglas, Andrew C. Williams, Alex Steltner, 1975 .

Evidence consistent with a stepwise elimination–addition process for hydrolysis and aminolysis of aryl toluene-α-sulphonates

K. Douglas, Andrew C. Williams, J. Loran, 1974 .

Photolability of bleomycin and its complexes.

K. Douglas, N. Thakrar, 1981, Cancer letters.

1H NMR spectroscopic identification of protonable sites in cryptolepines with C‐11 substituents containing two amino functionalities

J. Lavrado, K. Douglas, R. Moreira, 2012, Magnetic resonance in chemistry : MRC.

Leaving group effects in thiolester alkaline hydrolysis. Part 1. A keten-mediated (E1 cB) pathway for basic hydrolysis of S-acetoacetylcoenzyme A and analogues

K. Douglas, N. F. Yaggi, 1980 .

Thermodynamic, kinetic, and structural basis for recognition and repair of 8-oxoguanine in DNA by Fpg protein from Escherichia coli.

K. Douglas, G. Nevinsky, A. Ishchenko, 2002, Biochemistry.

A direct link between LY83583, a selective repressor of cyclic GMP formation, and glutathione metabolism.

K. Douglas, J. McKie, R. Lüönd, 1993, Biochemical pharmacology.

DNA mismatch detection by resonance energy transfer between ruthenium(II) and osmium(II) tris(2,2'-bipyridyl) chromophores.

K. Douglas, S. Faulkner, B. Coe, 2005, Inorganic chemistry.

Diagnosis of linear competitive inhibition

K. Douglas, A. Al-Timari, 1985 .

Site-directed mutagenesis of a serine residue in cinnamyl alcohol dehydrogenase, a plant NADPH-dependent dehydrogenase, affects the specificity for the coenzyme.

J. Grima-Pettenati, V. Lauvergeat, K. Douglas, 1995, Biochemistry.

A homology model of the three-dimensional structure of human O6-alkylguanine-DNA alkyltransferase based on the crystal structure of the C-terminal domain of the Ada protein from Escherichia coli.

D. Marks, J. Wibley, K. Douglas, 1995, Anti-cancer drug design.

Rational drug design using trypanothione reductase as a target for anti-trypanosomal and anti-leishmanial drug leads.

S. E. Austin, M. O. Khan, K. Douglas, 1999, Drug design and discovery.

A homology model of the Id-3 helix-loop-helix domain as a basis for structure-function predictions.

J. Wibley, J. Norton, K. Douglas, 1996, Biochimica et biophysica acta.

Quantum dot FRET biosensors that respond to pH, to proteolytic or nucleolytic cleavage, to DNA synthesis, or to a multiplexing combination.

Miho Suzuki, K. Douglas, Koji Suzuki, 2008, Journal of the American Chemical Society.

Carboxypeptidase Y from Saccharomyces cerevisiae. Conformational differences reflected in kinetic behaviour in water and deuterium oxide.

K. Douglas, Y. Nakagawa, J. Ghotb-Sharif, 1982, Biochimica et biophysica acta.

Tight binding of a copper (II) phthalocyanine (cuprolinic blue) to DNA.

K. Douglas, D. John, J. Rosamund, 1989, Biochemical and biophysical research communications.