I. Wittig

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High Resolution Clear Native Electrophoresis for In-gel Functional Assays and Fluorescence Studies of Membrane Protein Complexes*

Ilka Wittig, Michael Karas, H. Schägger, 2007, Molecular & Cellular Proteomics.

Blue native PAGE

H. Schägger, H. Braun, I. Wittig, 2006, Nature Protocols.

sST2 translation is regulated by FGF2 via an hnRNP A1-mediated IRES-dependent mechanism.

B. Brüne, T. Schmid, I. Wittig, 2016, Biochimica et biophysica acta.

Multiple pathways coordinate assembly of human mitochondrial complex IV and stabilization of respiratory supercomplexes

F. Fontanesi, J. Arenas, Miguel Ángel Martín, 2020, The EMBO journal.

Supercomplexes and subcomplexes of mitochondrial oxidative phosphorylation.

R. Carrozzo, H. Schägger, F. Santorelli, 2006, Biochimica et biophysica acta.

Two‐dimensional native electrophoretic analysis of respiratory supercomplexes from Yarrowia lipolytica

H. Schägger, I. Wittig, U. Brandt, 2009, Proteomics.

Structure of the yeast F1Fo-ATP synthase dimer and its role in shaping the mitochondrial cristae

W. Kühlbrandt, K. Davies, J. Faraldo-Gómez, 2012, Proceedings of the National Academy of Sciences.

Complexome profiling identifies TMEM126B as a component of the mitochondrial complex I assembly complex.

A. Reichert, I. Koch, I. Wittig, 2012, Cell metabolism.

Phenotypic spectrum of eleven patients and five novel MTFMT mutations identified by exome sequencing and candidate gene screening.

T. Wieland, T. Meitinger, T. Strom, 2014, Molecular genetics and metabolism.

Progranulin promotes peripheral nerve regeneration and reinnervation: role of notch signaling

Mirko H. H. Schmidt, S. Hardt, I. Wittig, 2016, Molecular Neurodegeneration.

Sequence-specific Peptide Aptamers, Interacting with the Intracellular Domain of the Epidermal Growth Factor Receptor, Interfere with Stat3 Activation and Inhibit the Growth of Tumor Cells*

Bernd Groner, Ilka Wittig, Christian Kunz, 2003, Journal of Biological Chemistry.

The interaction of specific peptide aptamers with the DNA binding domain and the dimerization domain of the transcription factor Stat3 inhibits transactivation and induces apoptosis in tumor cells.

Bernd Groner, Ilka Wittig, B. Groner, 2004, Molecular cancer research : MCR.

Exome sequencing identifies ACAD9 mutations as a cause of complex I deficiency

Thomas Meitinger, Joanna Poulton, Hans-Werner Mewes, 2010, Nature Genetics.

Autophagy-dependent PELI3 degradation inhibits proinflammatory IL1B expression

B. Brüne, A. Knethen, C. Behrends, 2014, Autophagy.

5-Lipoxygenase contributes to PPARγ activation in macrophages in response to apoptotic cells.

D. Steinhilber, B. Brüne, A. von Knethen, 2013, Cellular signalling.

Sulforaphane exposure impairs contractility and mitochondrial function in three-dimensional engineered heart tissue

K. Lorenz, M. Schweizer, I. Wittig, 2021, Redox biology.

Oxidation of cardiac myofilament proteins: Priming for dysfunction?

K. Lorenz, I. Wittig, P. Eaton, 2018, Molecular aspects of medicine.

Generator-specific targets of mitochondrial reactive oxygen species.

I. Wittig, U. Brandt, H. Heide, 2015, Free radical biology & medicine.

The mitochondrial complexome of Arabidopsis thaliana

Stephan Wagner, Hans-Peter Braun, Ilka Wittig, 2017, The Plant journal : for cell and molecular biology.

Platelet-derived calpain cleaves the endothelial protease-activated receptor 1 to induce vascular inflammation in diabetes

I. Fleming, I. Wittig, W. Ruf, 2020, Basic Research in Cardiology.

Interaction of the Escherichia coli transporter DctA with the sensor kinase DcuS: presence of functional DctA/DcuS sensor units

G. Unden, I. Wittig, J. Witan, 2012, Molecular microbiology.

H. Osiewacz, I. Wittig, U. Brandt, 2013, Journal of proteomics.

Cystathionine &ggr; Lyase Sulfhydrates the RNA Binding Protein Human Antigen R to Preserve Endothelial Cell Function and Delay Atherogenesis

R. Brandes, J. Pfeilschifter, A. Papapetropoulos, 2019, Circulation.

Isoform-specific Interaction of C-RAF with Mitochondria*

U. Rapp, J. Fueller, A. Galmiche, 2008, Journal of Biological Chemistry.

Respiratory Chain Complexes in Dynamic Mitochondria Display a Patchy Distribution in Life Cells

Jürgen Bereiter-Hahn, Ilka Wittig, Valentina Strecker, 2010, PloS one.

An Impaired Respiratory Electron Chain Triggers Down-regulation of the Energy Metabolism and De-ubiquitination of Solute Carrier Amino Acid Transporters*

D. Meierhofer, I. Wittig, C. Hardt, 2016, Molecular & Cellular Proteomics.

Imbalances in protein homeostasis caused by mutant desmin

W. H. Goldmann, W. Goldmann, U. Schlötzer-Schrehardt, 2018, Neuropathology and applied neurobiology.

Mass Estimation of Native Proteins by Blue Native Electrophoresis

H. Schägger, M. Karas, I. Wittig, 2010, Molecular & Cellular Proteomics.

Cytochrome P450 enzymes but not NADPH oxidases are the source of the NADPH‐dependent lucigenin chemiluminescence in membrane assays

R. Brandes, N. Weissmann, Nina Kurrle, 2017, Free radical biology & medicine.

Drug-Mediated Intracellular Donation of Nitric Oxide Potently Inhibits 5-Lipoxygenase: A Possible Key to Future Antileukotriene Therapy.

O. Werz, D. Steinhilber, E. Proschak, 2017, Antioxidants & redox signaling.

The splicing‐regulatory lncRNA NTRAS sustains vascular integrity

Andrea Knau, S. Dimmeler, S. Liebner, 2022, EMBO reports.

Cyp2c44 regulates prostaglandin synthesis, lymphangiogenesis, and metastasis in a mouse model of breast cancer

B. Brüne, I. Fleming, R. Popp, 2020, Proceedings of the National Academy of Sciences.

Loss of synaptic zinc transport in progranulin deficient mice may contribute to progranulin-associated psychopathology and chronic pain.

S. Hardt, I. Wittig, Christine Altmann, 2017, Biochimica et biophysica acta. Molecular basis of disease.

Progranulin overexpression in sensory neurons attenuates neuropathic pain in mice: Role of autophagy

Mirko H. H. Schmidt, S. Hardt, C. Behrends, 2016, Neurobiology of Disease.

Loss of mitochondrial ClpP, Lonp1, and Tfam triggers transcriptional induction of Rnf213, a susceptibility factor for moyamoya disease

C. López-Otín, I. Wittig, A. West, 2020, neurogenetics.

Inactivation of Tristetraprolin in Chronic Hypoxia Provokes the Expression of Cathepsin B

B. Brüne, T. Schmid, I. Wittig, 2014, Molecular and Cellular Biology.

Increased presence of nuclear DNAJA3 and upregulation of cytosolic STAT1 and of nucleic acid sensors trigger innate immunity in the ClpP-null mouse

I. Wittig, A. West, G. Auburger, 2021, neurogenetics.

AMP-Activated Protein Kinase α2 in Neutrophils Regulates Vascular Repair via Hypoxia-Inducible Factor-1α and a Network of Proteins Affecting Metabolism and Apoptosis

S. Wingert, F. Pampaloni, B. Walzog, 2017, Circulation research.

Redox Regulation of PPARγ in Polarized Macrophages

B. Brüne, A. von Knethen, I. Wittig, 2020, PPAR research.

Identification of the Mitochondrial ND3 Subunit as a Structural Component Involved in the Active/Deactive Enzyme Transition of Respiratory Complex I*

H. Schägger, M. Karas, I. Wittig, 2008, Journal of Biological Chemistry.

Protein S-nitrosylation and denitrosylation in the mouse spinal cord upon injury of the sciatic nerve.

I. Wittig, U. Brandt, H. Heide, 2012, Journal of proteomics.

Molecular diagnosis in mitochondrial complex I deficiency using exome sequencing

T. Wieland, T. Meitinger, T. Strom, 2012, Journal of Medical Genetics.

TLR2-Dependent Reversible Oxidation of Connexin 43 at Cys260 Modifies Electrical Coupling After Experimental Myocardial Ischemia/Reperfusion

R. Brandes, J. Roeper, M. Leisegang, 2019, Journal of Cardiovascular Translational Research.

Integrin α7β1 is a redox-regulated target of hydrogen peroxide in vascular smooth muscle cell adhesion.

I. Wittig, H. Heide, K. Schröder, 2012, Free radical biology & medicine.

S‐glutathiolation impairs phosphoregulation and function of cardiac myosin‐binding protein C in human heart failure

D. Dobrev, S. Sadayappan, I. Wittig, 2016, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Interleukin-38 is released from apoptotic cells to limit inflammatory macrophage responses.

Andrea Schlemmer, B. Brüne, I. Wittig, 2016, Journal of molecular cell biology.

Loss of mitochondrial peptidase Clpp leads to infertility, hearing loss plus growth retardation via accumulation of CLPX, mtDNA and inflammatory factors

D. Busch, S. Koob, A. Reichert, 2013, Human molecular genetics.

Human Ind1, an Iron-Sulfur Cluster Assembly Factor for Respiratory Complex I

J. Balk, I. Wittig, H. Elsässer, 2009, Molecular and Cellular Biology.

SYNCRIP-dependent Nox2 mRNA destabilization impairs ROS formation in M2-polarized macrophages.

R. Brandes, B. Brüne, A. von Knethen, 2014, Antioxidants & redox signaling.

MTO1-Deficient Mouse Model Mirrors the Human Phenotype Showing Complex I Defect and Cardiomyopathy

H. Fuchs, A. Walch, M. Aichler, 2014, PloS one.

Reviewers' comments: Reviewer #1 (Remarks to the Author): Trembinski et al. Sarrah is an Aging-Regulated Anti-Apoptotic Long Non-Coding RNA in Cardiomyocytes that Augments Recovery from Acute Myocardial Infarction

Christopher N. Johnson, R. Brandes, S. Dimmeler, 2020 .

MIC26 and MIC27 cooperate to regulate cardiolipin levels and the landscape of OXPHOS complexes

A. Reichert, I. Wittig, T. Eichmann, 2020, Life Science Alliance.

High-resolution cryo-EM structures of respiratory complex I: Mechanism, assembly, and disease

Vivek Sharma, W. Kühlbrandt, H. Köfeler, 2019, Science Advances.

How many molecules of mitochondrial complex I are in a cell?

I. Wittig, V. Ten, A. Galkin, 2022, Analytical biochemistry.

Identification of TRIM25 as a Negative Regulator of Caspase-2 Expression Reveals a Novel Target for Sensitizing Colon Carcinoma Cells to Intrinsic Apoptosis

J. Pfeilschifter, W. Eberhardt, I. Wittig, 2019, Cells.

ATP Synthase Deficiency due to TMEM70 Mutation Leads to Ultrastructural Mitochondrial Degeneration and Is Amenable to Treatment

Anne K. Braczynski, K. Plate, H. Goebel, 2015, BioMed research international.

Large pore gels to separate mega protein complexes larger than 10 MDa by blue native electrophoresis: Isolation of putative respiratory strings or patches

H. Schägger, I. Wittig, Valentina Strecker, 2010, Proteomics.

Quantification of protein complexes by blue native electrophoresis.

I. Wittig, Valentina Strecker, J. Heidler, 2013, Methods in molecular biology.

Mapping the Endothelial Cell S-Sulfhydrome Highlights the Crucial Role of Integrin Sulfhydration in Vascular Function.

S. Knapp, R. Brandes, S. Dimmeler, 2020, Circulation.

A novel role for cystathionine γ lyase in the control of p53: impact on endothelial senescence and metabolic reprograming

S. Knapp, R. Brandes, M. Leisegang, 2022, bioRxiv.

Loss of Mitochondrial Protease CLPP Activates Type I IFN Responses through the Mitochondrial DNA–cGAS–STING Signaling Axis

I. Wittig, A. West, G. Auburger, 2021, The Journal of Immunology.

Electrophoretic methods to isolate protein complexes from mitochondria.

H. Schägger, I. Wittig, 2007, Methods in cell biology.

Degradation of the mitochondrial complex I assembly factor TMEM126B under chronic hypoxia

B. Brüne, T. Schmid, I. Wittig, 2018, Cellular and Molecular Life Sciences.

Unmasking a temperature-dependent effect of the P. anserina i-AAA protease on aging and development

H. Osiewacz, I. Wittig, U. Brandt, 2011, Cell cycle.

Laser‐induced liquid bead ion desorption‐MS of protein complexes from blue‐native gels, a sensitive top‐down proteomic approach

H. Schägger, I. Wittig, U. Brandt, 2010, Proteomics.

Chapter 8 Two-dimensional native electrophoresis for fluorescent and functional assays of mitochondrial complexes.

H. Schägger, I. Wittig, Esther Nübel, 2009, Methods in enzymology.

Functional assays in high‐resolution clear native gels to quantify mitochondrial complexes in human biopsies and cell lines

R. Carrozzo, H. Schägger, F. Santorelli, 2007, Electrophoresis.

ArgC-Like Digestion: Complementary or Alternative to Tryptic Digestion?

M. Karas, U. Bahr, I. Wittig, 2017, Journal of proteome research.

Insights into complex I assembly: Function of NDUFAF1 and a link with cardiolipin remodeling

W. Kühlbrandt, I. Wittig, J. Vonck, 2022, Science advances.

Mitochondrial membrane assembly of TMEM70 protein.

K. Hejzlarová, M. Tesařová, M. Vrbacký, 2014, Mitochondrion.

Homozygous missense mutation in BOLA3 causes multiple mitochondrial dysfunctions syndrome in two siblings

T. Meitinger, T. Strom, H. Prokisch, 2013, Journal of Inherited Metabolic Disease.

Dicer cleavage by calpain determines platelet microRNA levels and function in diabetes.

I. Fleming, Lei Shi, I. Wittig, 2015, Circulation research.

Structural organization of mitochondrial ATP synthase.

H. Schägger, I. Wittig, 2008, Biochimica et biophysica acta.

Mitochondrion-derived reactive oxygen species lead to enhanced amyloid beta formation.

R. Palmiter, A. Occhipinti, A. Reichert, 2012, Antioxidants & redox signaling.

Long Noncoding RNA MANTIS Facilitates Endothelial Angiogenic Function

K. Plate, S. Pullamsetti, R. Brandes, 2017, Circulation.

A Bak-dependent mitochondrial amplification step contributes to Smac mimetic/glucocorticoid-induced necroptosis

S. Fulda, I. Wittig, S. Dröse, 2016, Cell Death and Differentiation.

TMEM126B deficiency reduces mitochondrial SDH oxidation by LPS, attenuating HIF-1α stabilization and IL-1β expression

B. Brüne, I. Wittig, D. Fuhrmann, 2018, Redox biology.

Redox Activation of Nox1 (NADPH Oxidase 1) Involves an Intermolecular Disulfide Bond Between Protein Disulfide Isomerase and p47phox in Vascular Smooth Muscle Cells

R. Brandes, L. Lopes, J. Rosa, 2019, Arteriosclerosis, thrombosis, and vascular biology.

Endo-PDI is required for TNFα-induced angiogenesis.

R. Brandes, L. Lopes, K. Rajalingam, 2013, Free radical biology & medicine.

The Endoplasmic Reticulum Chaperone Calnexin Is a NADPH Oxidase NOX4 Interacting Protein*

A. Shah, R. Brandes, N. Weissmann, 2016, The Journal of Biological Chemistry.

Progranulin promotes peripheral nerve regeneration and reinnervation: role of notch signaling

Mirko H. H. Schmidt, S. Hardt, I. Wittig, 2016, Molecular Neurodegeneration.

Mutant desmin substantially perturbs mitochondrial morphology, function and maintenance in skeletal muscle tissue

R. Kley, W. Kunz, I. Wittig, 2016, Acta Neuropathologica.

Mitochondrial respiratory chain complexes as sources and targets of thiol-based redox-regulation.

I. Wittig, U. Brandt, S. Dröse, 2014, Biochimica et biophysica acta.

The Mitochondrial Genome of the Venomous Cone Snail Conus consors

A. Kurz, Holly Baden-Tillson, R. Stöcklin, 2012, PloS one.

Supercomplex-associated Cox26 protein binds to cytochrome c oxidase.

C. Cruciat, K. Pfeiffer, R. Stuart, 2016, Biochimica et biophysica acta.

Aging-regulated anti-apoptotic long non-coding RNA Sarrah augments recovery from acute myocardial infarction

Christopher N. Johnson, R. Brandes, S. Dimmeler, 2020, Nature Communications.

Nitric oxide maintains endothelial redox homeostasis through PKM2 inhibition

B. Brüne, Sofia-Iris Bibli, B. Fisslthaler, 2019, The EMBO journal.

Cytopathic effects of the cytomegalovirus-encoded apoptosis inhibitory protein vMIA

G. Kroemer, P. Rustin, H. Schägger, 2006, The Journal of cell biology.

Characterising a homozygous two‐exon deletion in UQCRH: comparing human and mouse phenotypes

Robert W. Taylor, H. Fuchs, W. Wurst, 2021, EMBO molecular medicine.

Respiratory chain signalling is essential for adaptive remodelling following cardiac ischaemia

H. Jacobs, T. Nyman, E. Dufour, 2020, Journal of cellular and molecular medicine.

Bioenergetic consequences from xenotopic expression of a tunicate AOX in mouse mitochondria: Switch from RET and ROS to FET.

E. Dufour, I. Wittig, A. Moore, 2019, Biochimica et biophysica acta. Bioenergetics.

Genetic deletion of Nox4 enhances cancerogen-induced formation of solid tumors

A. Shah, S. Fulda, R. Brandes, 2021, Proceedings of the National Academy of Sciences.

HIF1α-AS1 is a DNA:DNA:RNA triplex-forming lncRNA interacting with the HUSH complex

Marcel H. Schulz, H. Schwalbe, S. Pullamsetti, 2021, bioRxiv.

A salvage pathway maintains highly functional respiratory complex I

J. Riemer, I. Wittig, S. Guerrero-Castillo, 2020, Nature Communications.

AKAP12 deficiency impairs VEGF‐induced endothelial cell migration and sprouting

I. Fleming, R. Popp, I. Wittig, 2019, Acta physiologica.

The proteogenomic subtypes of acute myeloid leukemia.

J. Cox, F. Buettner, A. Trumpp, 2022, Cancer cell.

Proteomics-Based Approach to Identify Novel Blood Biomarker Candidates for Differentiating Intracerebral Hemorrhage From Ischemic Stroke—A Pilot Study

I. Wittig, C. Foerch, S. Luger, 2021, Frontiers in Neurology.

The biochemical basis of mitochondrial dysfunction in Zellweger Spectrum Disorder

Katie J. Clowers, S. Gygi, J. Rutter, 2021, EMBO reports.

Msp1/ATAD1 restores mitochondrial function in Zellweger Spectrum Disease

Katie J. Clowers, S. Gygi, J. Rutter, 2020 .

Mitochondrial DNA copy number and function decrease with age in the short‐lived fish Nothobranchius furzeri

Matthias Platzer, Ulrike Gausmann, Ulrich Brandt, 2011, Aging cell.

Complexome Profiling: Assembly and Remodeling of Protein Complexes

I. Wittig, P. Malacarne, 2021, International journal of molecular sciences.

Conserved and species-specific molecular denominators in mammalian skeletal muscle aging

E. Mercken, R. de Cabo, K. Becker, 2017, npj Aging and Mechanisms of Disease.

Myeloid-Specific Deletion of the AMPKα2 Subunit Alters Monocyte Protein Expression and Atherogenesis

O. Soehnlein, B. Fisslthaler, I. Fleming, 2019, International journal of molecular sciences.

CEDAR, an online resource for the reporting and exploration of complexome profiling data.

M. Huynen, J. Choudhary, Petra Páleníková, 2021, Biochimica et biophysica acta. Bioenergetics.

CEDAR, an online resource for the reporting and exploration of complexome profiling data

Uwe Schulte, Mercedes Pardo, Jyoti S. Choudhary, 2020, bioRxiv.

Inactivity of Peptidase ClpP Causes Primary Accumulation of Mitochondrial Disaggregase ClpX with Its Interacting Nucleoid Proteins, and of mtDNA

H. Prokisch, S. Sieber, I. Wittig, 2021, Cells.

Impaired complex I repair causes recessive Leber’s hereditary optic neuropathy

T. Strom, H. Prokisch, P. Charbel Issa, 2021, The Journal of clinical investigation.

Pathogenic Bi-allelic Mutations in NDUFAF8 Cause Leigh Syndrome with an Isolated Complex I Deficiency

Holger Prokisch, Robert W. Taylor, Langping He, 2019, American journal of human genetics.

Bi-allelic Mutations in NDUFA6 Establish Its Role in Early-Onset Isolated Mitochondrial Complex I Deficiency

Robert W. Taylor, Courtney E. French, A. Pagnamenta, 2018, American Journal of Human Genetics.

Quantitative Persulfide Site Identification (qPerS-SID) Reveals Protein Targets of H2S Releasing Donors in Mammalian Cells

J. Pfeilschifter, I. Wittig, F. Richter, 2016, Scientific Reports.

Cytochrome c Oxidase Biogenesis and Metallochaperone Interactions: Steps in the Assembly Pathway of a Bacterial Complex

Ilka Wittig, I. Wittig, B. Ludwig, 2017, PloS one.

Identification of the TXNIP IRES and characterization of the impact of regulatory IRES trans-acting factors.

B. Brüne, T. Schmid, I. Wittig, 2018, Biochimica et biophysica acta. Gene regulatory mechanisms.

Loss of mitochondrial protease CLPP activates type I interferon responses through the mtDNA-cGAS-STING signaling axis

I. Wittig, A. West, G. Auburger, 2020 .

Long Non-coding RNA Aerrie Controls DNA Damage Repair via YBX1 to Maintain Endothelial Cell Function

S. Dimmeler, U. Hedin, I. Wittig, 2021, Frontiers in Cell and Developmental Biology.

An artificial transport metabolon facilitates improved substrate utilization in yeast.

Jun-Yong Choe, Ilka Wittig, E. Boles, 2017, Nature chemical biology.

Cellular differentiation state modulates the mRNA export activity of SR proteins

I. Poser, I. Wittig, K. Neugebauer, 2017, The Journal of cell biology.

Calpain 1 cleaves and inactivates prostacyclin synthase in mesenteric arteries from diabetic mice

I. Fleming, I. Wittig, Sven Zukunft, 2016, Basic Research in Cardiology.

Metabolic Maturation during Muscle Stem Cell Differentiation Is Achieved by miR-1/133a-Mediated Inhibition of the Dlk1-Dio3 Mega Gene Cluster.

S. Günther, I. Wittig, T. Boettger, 2018, Cell metabolism.

Identification of Two Proteins Associated with Mammalian ATP Synthase*S

H. Schägger, M. Karas, I. Wittig, 2007, Molecular & Cellular Proteomics.

The Consequences of Soluble Epoxide Hydrolase Deletion on Tumorigenesis and Metastasis in a Mouse Model of Breast Cancer

B. Brüne, I. Fleming, R. Popp, 2021, International journal of molecular sciences.

Hydrogen peroxide formation by Nox4 limits malignant transformation

R. Brandes, B. Brüne, T. Schmid, 2017, bioRxiv.

Assembly and oligomerization of human ATP synthase lacking mitochondrial subunits a and A6L.

H. Schägger, M. Karas, I. Wittig, 2010, Biochimica et biophysica acta.

Characterization of Domain Interfaces in Monomeric and Dimeric ATP Synthase*

R. Stuart, H. Schägger, I. Wittig, 2008, Molecular & Cellular Proteomics.

Activation of Caspase-6 Is Promoted by a Mutant Huntingtin Fragment and Blocked by an Allosteric Inhibitor Compound.

D. Ehrnhoefer, M. Hayden, A. Renslo, 2019, Cell chemical biology.

Subcomplexes of human ATP synthase mark mitochondrial biosynthesis disorders

R. Carrozzo, H. Schägger, F. Santorelli, 2006, Annals of neurology.

Cristae architecture is determined by an interplay of the MICOS complex and the F1FO ATP synthase via Mic27 and Mic10

A. Reichert, K. Davies, I. Wittig, 2017, Microbial cell.

Mic13 Is Essential for Formation of Crista Junctions in Mammalian Cells

A. Reichert, I. Wittig, Ruchika Anand, 2016, PloS one.

APOOL Is a Cardiolipin-Binding Constituent of the Mitofilin/MINOS Protein Complex Determining Cristae Morphology in Mammalian Mitochondria

Andreas S. Reichert, Ulrich Brandt, Ilka Wittig, 2013, PloS one.

Deep proteome of human nNOS/NOS1-positive versus MOCK SH-SY5Y neuroblastoma cells under full nutrition, serum free starvation and rapamycin treatment

I. Wittig, J. Heidler, I. Tegeder, 2018, Data in brief.

Mutational Analysis of the QRRQ Motif in the Yeast Hig1 Type 2 Protein Rcf1 Reveals a Regulatory Role for the Cytochrome c Oxidase Complex*

R. Stuart, I. Wittig, Valentina Strecker, 2017, The Journal of Biological Chemistry.

VCP and PSMF1: Antagonistic regulators of proteasome activity.

W. Rottbauer, I. Blümcke, L. Eichinger, 2015, Biochemical and biophysical research communications.

Features and applications of blue‐native and clear‐native electrophoresis

H. Schägger, I. Wittig, 2008, Proteomics.

Supramolecular organization of ATP synthase and respiratory chain in mitochondrial membranes.

H. Schägger, I. Wittig, 2009, Biochimica et biophysica acta.

Enriched conditioning expands the regenerative ability of sensory neurons after spinal cord injury via neuronal intrinsic redox signaling

J. Bixby, S. Di Giovanni, A. Shah, 2020, Nature Communications.

Accessory subunit NUYM (NDUFS4) is required for stability of the electron input module and activity of mitochondrial complex I.

I. Wittig, V. Zickermann, K. Zwicker, 2017, Biochimica et biophysica acta. Bioenergetics.

ATP synthases: cellular nanomotors characterized by LILBID mass spectrometry.

H. Schägger, N. Morgner, T. A. Krulwich, 2010, Physical chemistry chemical physics : PCCP.

NADPH oxidase subunit NOXO1 is a target for emphysema treatment in COPD

Andreas Günther, R. Brandes, N. Weissmann, 2020, Nature Metabolism.

NADPH oxidase subunit NOXO1 is a target for emphysema treatment in COPD

W. Seeger, A. Günther, C. Vogelmeier, 2020, Nature Metabolism.

Quantification of NADH:ubiquinone oxidoreductase (complex I) content in biological samples

Edward Owusu-Ansah, I. Wittig, Belem Yoval-Sánchez, 2021, The Journal of biological chemistry.

Redox-dependent loss of flavin by mitochondrial complex I in brain ischemia/reperfusion injury.

I. Wittig, A. Starkov, V. Ten, 2019, Antioxidants & redox signaling.

SRSF7 maintains its homeostasis through the expression of Split-ORFs and nuclear body assembly

Marcel H. Schulz, I. Wittig, Michaela Müller-McNicoll, 2020, Nature Structural & Molecular Biology.

Poison cassette exon splicing of SRSF6 regulates nuclear speckle dispersal and the response to hypoxia

S. Dimmeler, I. Wittig, María Clara Hernández Cañás, 2023, Nucleic acids research.

Chronic hypoxia alters mitochondrial composition in human macrophages.

B. Brüne, I. Wittig, H. Heide, 2013, Biochimica et biophysica acta.

Determination of protein mobility in mitochondrial membranes of living cells.

J. Bereiter-Hahn, I. Wittig, K. Busch, 2010, Biochimica et biophysica acta.

NOVA: a software to analyze complexome profiling data

Ina Koch, Jörg Ackermann, Ulrich Brandt, 2015, Bioinform..

Signal transducer and activator of transcription 5 (STAT5), a crucial regulator of immune and cancer cells.

B. Groner, I. Wittig, 2005, Current drug targets. Immune, endocrine and metabolic disorders.

Characterization of the novel OXA-213-like β-lactamase OXA-822 from Acinetobacter calcoaceticus.

E. Proschak, I. Wittig, S. Göttig, 2020, The Journal of antimicrobial chemotherapy.

Global Proteome of LonP1+/− Mouse Embryonal Fibroblasts Reveals Impact on Respiratory Chain, but No Interdependence between Eral1 and Mitoribosomes

C. López-Otín, I. Wittig, G. Auburger, 2019, International journal of molecular sciences.

Global Proteome of LonP1+/− Mouse Embryonal Fibroblasts Reveals Impact on Respiratory Chain, but No Interdependence between Eral1 and Mitoribosomes

C. López-Otín, I. Wittig, G. Auburger, 2019, International journal of molecular sciences.

Nitric oxide contributes to protein homeostasis by S-nitrosylations of the chaperone HSPA8 and the ubiquitin ligase UBE2D

I. Wittig, J. Heidler, I. Tegeder, 2018, Redox biology.

Nitric Oxide-associated Protein 1 (NOA1) Is Necessary for Oxygen-dependent Regulation of Mitochondrial Respiratory Complexes*

I. Wittig, P. Seibel, M. Krüger, 2011, The Journal of Biological Chemistry.

ND3, ND1 and 39 kDa subunits are more exposed in the de-active form of bovine mitochondrial complex I

C. Botting, M. Babot, I. Wittig, 2014, Biochimica et biophysica acta.

Mutations in a conserved loop in the PSST subunit of respiratory complex I affect ubiquinone binding and dynamics.

Vivek Sharma, I. Wittig, V. Zickermann, 2019, Biochimica et biophysica acta. Bioenergetics.

The LYR protein subunit NB4M/NDUFA6 of mitochondrial complex I anchors an acyl carrier protein and is essential for catalytic activity

M. Radermacher, I. Wittig, U. Brandt, 2014, Proceedings of the National Academy of Sciences.

Redox-dependent loss of flavin by mitochondria complex I is different in brain and heart

R. Rafikov, I. Wittig, I. Tikhonova, 2022, Redox biology.

Subunit mass fingerprinting of mitochondrial complex I.

N. Morgner, I. Wittig, U. Brandt, 2008, Biochimica et biophysica acta.

SNO-ing at the Nociceptive Synapse?

I. Wittig, G. Geisslinger, I. Tegeder, 2011, Pharmacological Reviews.

AMPK activates LXRα and ABCA1 expression in human macrophages.

B. Brüne, I. Wittig, F. Richter, 2016, The international journal of biochemistry & cell biology.

N471D WASH complex subunit strumpellin knock‐in mice display mild motor and cardiac abnormalities and BPTF and KLHL11 dysregulation in brain tissue

H. Fuchs, L. Eichinger, V. Gailus-Durner, 2021, Neuropathology and applied neurobiology.

Aging of Podospora anserina Leads to Alterations of OXPHOS and the Induction of Non-Mitochondrial Salvage Pathways

H. Osiewacz, I. Wittig, Jana Meisterknecht, 2021, Cells.

Biallelic Mutations in TMEM126B Cause Severe Complex I Deficiency with a Variable Clinical Phenotype

Katrien Stouffs, Melanie Bahlo, Holger Prokisch, 2016, American journal of human genetics.

Methods to analyse composition and dynamics of macromolecular complexes.

I. Wittig, H. Heide, 2013, Biochemical Society transactions.

Advantages and limitations of clear‐native PAGE

Ilka Wittig, H. Schägger, I. Wittig, 2005, Proteomics.

Bi‐allelic pathogenic variants in NDUFC2 cause early‐onset Leigh syndrome and stalled biogenesis of complex I

Robert W. Taylor, E. Lamantea, I. Wittig, 2020, EMBO molecular medicine.

Acyl modification and binding of mitochondrial ACP to multiprotein complexes.

M. Karas, U. Bahr, N. Morgner, 2017, Biochimica et biophysica acta. Molecular cell research.

Mitochondrial dynamics generate equal distribution but patchwork localization of respiratory Complex I

J. Bereiter-Hahn, I. Wittig, M. Jendrach, 2006, Molecular membrane biology.

Recognition of enzymes lacking bound cofactor by protein quality control

R. Vabulas, I. Wittig, Marion Alriquet, 2016, Proceedings of the National Academy of Sciences.

Clinical, biochemical and genetic spectrum of 70 patients with ACAD9 deficiency: is riboflavin supplementation effective?

Robert W. Taylor, T. Wieland, A. Munnich, 2018, Orphanet Journal of Rare Diseases.

Nox4-Dependent Upregulation of S100A4 after Peripheral Nerve Injury Modulates Neuropathic Pain Processing.

R. Brandes, A. Bresnick, I. Wittig, 2021, Free radical biology & medicine.

Ena/VASP proteins mediate endothelial cell repulsion from ephrin ligands

I. Wittig, Timo Frömel, I. Fleming, 2023, bioRxiv.

Expression of PKM2 in wound keratinocytes is coupled to angiogenesis during skin repair in vivo and in HaCaT keratinocytes in vitro

J. Pfeilschifter, I. Wittig, I. Goren, 2023, Journal of Molecular Medicine.

The polarity protein Scrib limits atherosclerosis development in mice.

Jun Zhu, R. Brandes, B. van de Sluis, 2019, Cardiovascular research.

Targeting long non-coding RNA NUDT6 enhances smooth muscle cell survival and limits vascular disease progression

Derek J Van Booven, B. Khomtchouk, Derek J. Van Booven, 2022, bioRxiv.

Hodgkin and Reed–Sternberg cells of classical Hodgkin lymphoma are highly dependent on oxidative phosphorylation

A. Reichert, M. Hansmann, I. Wittig, 2016, International journal of cancer.

Reduced exploratory behavior in neuronal nucleoredoxin knockout mice

I. Wittig, I. Tegeder, L. Valek, 2021, Redox biology.

Rab7—a novel redox target that modulates inflammatory pain processing

I. Wittig, A. Edinger, G. Geisslinger, 2017, Pain.

Broad AOX expression in a genetically tractable mouse model does not disturb normal physiology

H. Fuchs, H. Jacobs, P. Rustin, 2017, Disease Models & Mechanisms.

BIAM switch assay coupled to mass spectrometry identifies novel redox targets of NADPH oxidase 4

R. Brandes, I. Wittig, K. Schröder, 2019, Redox biology.

Cluster analysis and visualization techniques for large datasets in complexome profiling

Ina Koch, Jörg Ackermann, Ulrich Brandt, 2015, PeerJ Prepr..

Prediction and analysis of redox-sensitive cysteines using machine learning and statistical methods

I. Koch, I. Wittig, Marcus Keßler, 2021, Biological chemistry.

Long non-coding RNA LASSIE regulates shear stress sensing and endothelial barrier function

F. le Noble, D. Stainier, S. Dimmeler, 2020, Communications Biology.

Native electrophoretic techniques to identify protein–protein interactions

H. Schägger, I. Wittig, 2009, Proteomics.

Locus-Conserved Circular RNA cZNF292 Controls Endothelial Cell Flow Responses

C. Dieterich, S. Dimmeler, M. Sattler, 2021, Circulation research.

Platelet-derived growth factor triggers PKA-mediated signalling by a redox-dependent mechanism in rat renal mesangial cells.

J. Pfeilschifter, I. Wittig, K. Beck, 2013, Biochemical pharmacology.

Redox-proteomes of human NOS1-transduced versus MOCK SH-SY5Y neuroblastoma cells under full nutrition, serum-free starvation, and rapamycin treatment

I. Wittig, J. Heidler, I. Tegeder, 2018, Data in brief.

Mutagenesis of complex I from Thermus thermophilus

Manuela M. Pereira, C. Botting, M. Babot, 2014 .

Coi1 is a novel assembly factor of the yeast complex III–complex IV supercomplex

I. Wittig, J. Herrmann, D. Rapaport, 2017, Molecular biology of the cell.

ADPGK‐AS1 long noncoding RNA switches macrophage metabolic and phenotypic state to promote lung cancer growth

C. Ruppert, S. Pullamsetti, R. Savai, 2023, The EMBO journal.

Expanding the phenotypic and biochemical spectrum of NDUFAF3-related mitochondrial disease.

H. Prokisch, M. Hempel, I. Wittig, 2023, Molecular genetics and metabolism.

A salvage pathway maintains highly functional respiratory complex I

J. Riemer, I. Wittig, S. Guerrero-Castillo, 2020, Nature Communications.

Ubiquitylome profiling of Parkin-null brain reveals dysregulation of calcium homeostasis factors ATP1A2, Hippocalcin and GNA11, reflected by altered firing of noradrenergic neurons

I. Wittig, N. Decher, C. Münch, 2019, Neurobiology of Disease.

SRSF7 maintains its homeostasis through the expression of Split-ORFs and nuclear body assembly

Marcel H. Schulz, I. Wittig, Michaela Müller-McNicoll, 2020, Nature Structural & Molecular Biology.

Mitochondrial Complexome Profiling.

I. Wittig, J. Heidler, Jana Meisterknecht, 2021, Methods in molecular biology.

Non-classical 2-D electrophoresis.

H. Schägger, I. Wittig, Jacqueline Burré, 2009, Methods in molecular biology.

Human platelets are a source of collagen I.

I. Fleming, I. Wittig, A. Kyselova, 2020, Haematologica.

SYNCRIP-dependent Nox2 mRNA destabilization impairs ROS formation in M2-polarized macrophages.

R. Brandes, B. Brüne, A. von Knethen, 2014, Antioxidants & redox signaling.

Progranulin overexpression in sensory neurons attenuates neuropathic pain in mice: Role of autophagy

Mirko H. H. Schmidt, S. Hardt, C. Behrends, 2016, Neurobiology of Disease.

SNO-ing at the Nociceptive Synapse?

I. Wittig, G. Geisslinger, I. Tegeder, 2011, Pharmacological Reviews.

Large pore gels to separate mega protein complexes larger than 10 MDa by blue native electrophoresis: Isolation of putative respiratory strings or patches

H. Schägger, I. Wittig, Valentina Strecker, 2010, Proteomics.

Acyl modification and binding of mitochondrial ACP to multiprotein complexes.

M. Karas, U. Bahr, N. Morgner, 2017, Biochimica et biophysica acta. Molecular cell research.

Metabolic Maturation during Muscle Stem Cell Differentiation Is Achieved by miR-1/133a-Mediated Inhibition of the Dlk1-Dio3 Mega Gene Cluster.

S. Günther, I. Wittig, T. Boettger, 2018, Cell metabolism.

Mass Estimation of Native Proteins by Blue Native Electrophoresis

H. Schägger, M. Karas, I. Wittig, 2010, Molecular & Cellular Proteomics.

Broad AOX expression in a genetically tractable mouse model does not disturb normal physiology

H. Fuchs, H. Jacobs, P. Rustin, 2017, Disease Models & Mechanisms.

Cytopathic effects of the cytomegalovirus-encoded apoptosis inhibitory protein vMIA

G. Kroemer, P. Rustin, H. Schägger, 2006, The Journal of cell biology.

The long non-coding RNA MEG8 induces an endothelial barrier through regulation of microRNA-370 and -494 processing

A. Tijsen, I. Wittig, R. Boon, 2022, Journal of Cell Science.

Phenotypic spectrum of eleven patients and five novel MTFMT mutations identified by exome sequencing and candidate gene screening.

T. Wieland, T. Meitinger, T. Strom, 2014, Molecular genetics and metabolism.

H. Osiewacz, I. Wittig, U. Brandt, 2013, Journal of proteomics.

Global Proteome of LonP1+/− Mouse Embryonal Fibroblasts Reveals Impact on Respiratory Chain, but No Interdependence between Eral1 and Mitoribosomes

C. López-Otín, I. Wittig, G. Auburger, 2019, International journal of molecular sciences.