D. Dean

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Postmitotic nuclear retention of episomal plasmids is altered by DNA labeling and detection methods.

J. Gasiorowski, D. Dean, Joshua Z Gasiorowski, 2005, Molecular therapy : the journal of the American Society of Gene Therapy.

Introduction Nonviral Gene Delivery

J. Gasiorowski, D. Dean, 2011 .

Gene therapy for ALI/ARDS.

D. Dean, Xin Lin, 2011, Critical care clinics.

Nonviral gene delivery.

J. Gasiorowski, D. Dean, Joshua Z Gasiorowski, 2011, Cold Spring Harbor protocols.

Intracellular trafficking of plasmids for gene therapy: mechanisms of cytoplasmic movement and nuclear import.

D. Dean, E. Vaughan, James V. DeGiulio, 2006, Current gene therapy.

Electroporation-mediated gene delivery.

D. Dean, Jennifer L Young, Jennifer L. Young, 2015, Advances in genetics.

Nuclear Import of Plasmid DNA in Digitonin-permeabilized Cells Requires Both Cytoplasmic Factors and Specific DNA Sequences*

G. Wilson, D. Dean, B. Dean, 1999, The Journal of Biological Chemistry.

Import of plasmid DNA into the nucleus is sequence specific.

D. Dean, D A Dean, 1997, Experimental cell research.

Nuclear Import of DNA

D. Dean, K. E. Gokay, 2005 .

Dendrimer-assisted patch-clamp sizing of nuclear pores

T. McDonnell, J. Hanover, J. Geibel, 2000, Pflügers Archiv.

Cell-specific nuclear import of plasmid DNA

W. Zimmer, D. Dean, B. Dean, 1999, Gene Therapy.

Tissue-specific and transcription factor-mediated nuclear entry of DNA.

Aaron M. Miller, D. Dean, David A Dean, 2009, Advanced drug delivery reviews.

Cytoplasmic transport and nuclear import of plasmid DNA

David A. Dean, D. Dean, Haiqing Bai, 2017, Bioscience reports.

Extracellular and Intracellular Barriers to Non-Viral Gene Transfer

D. Dean, L. Gottfried, 2013 .

Insertion of a nuclear factor kappa B DNA nuclear-targeting sequence potentiates suicide gene therapy efficacy in lung cancer cell lines

C. Christensen, D. Dean, T. T. Poulsen, 2012, Cancer Gene Therapy.

Microtubule acetylation through HDAC6 inhibition results in increased transfection efficiency.

Aaron M. Miller, Takayoshi Suzuki, D. Dean, 2008, Molecular therapy : the journal of the American Society of Gene Therapy.

Peptide nucleic acids: versatile tools for gene therapy strategies.

D. Dean, 2000, Advanced drug delivery reviews.

Proteomic and functional analyses of protein-DNA complexes during gene transfer.

J. Lapek, D. Dean, M. Badding, 2013, Molecular therapy : the journal of the American Society of Gene Therapy.

Effect of a DNA nuclear targeting sequence on gene transfer and expression of plasmids in the intact vasculature

D. Dean, J. Benoit, Jennifer L. Young, 2003, Gene Therapy.

Hyperoxia-induced Apoptosis Does Not Require Mitochondrial Reactive Oxygen Species and Is Regulated by Bcl-2 Proteins*

J. Sznajder, N. Chandel, G. S. Budinger, 2002, The Journal of Biological Chemistry.

Nonviral Gene Transfer Strategies for the Vasculature

D. Dean, Jennifer L Young, Jennifer L. Young, 2002, Microcirculation.

Pulmonary gene delivery—Realities and possibilities

D. Dean, Uday K Baliga, 2020, Experimental biology and medicine.

Identification and Functional Characterization of Cytoplasmic Determinants of Plasmid DNA Nuclear Import*

D. Geddes, M. Ward, M. Dunn, 2009, The Journal of Biological Chemistry.

Identification of protein cofactors necessary for sequence-specific plasmid DNA nuclear import.

Aaron M. Miller, D. Dean, E. Alton, 2009, Molecular therapy : the journal of the American Society of Gene Therapy.

Highly Acetylated Tubulin Permits Enhanced Interactions with and Trafficking of Plasmids Along Microtubules

D. Dean, M. Badding, 2012, Gene Therapy.

Identification of an alveolar type I epithelial cell-specific DNA nuclear import sequence for gene delivery

D. Dean, Xin Lin, L. Gottfried, 2016, Gene Therapy.

DNA Targeting Sequence Improves Magnetic Nanoparticle-Based Plasmid DNA Transfection Efficiency in Model Neurons

J. Dobson, D. Dean, M. Vernon, 2015, International journal of molecular sciences.

β1-Na+,K+-ATPase gene therapy upregulates tight junctions to rescue lipopolysaccharide-induced acute lung injury

D. Dean, Xin Lin, X. Lin, 2016, Gene Therapy.

Neonatal oxygen adversely affects lung function in adult mice without altering surfactant composition or activity.

M. O’Reilly, S. McGrath-Morrow, R. Notter, 2009, American journal of physiology. Lung cellular and molecular physiology.

Nucleotide sequence analysis of alpha-amylase and thiol protease genes that are hormonally regulated in barley aleurone cells.

D. Dean, J. Rogers, R. Whittier, 1987, Nucleic acids research.

Leptin resistance protects mice from hyperoxia-induced acute lung injury.

G. Mutlu, N. Chandel, D. Dean, 2007, American journal of respiratory and critical care medicine.

Leptomycin B alters the subcellular distribution of CRM1 (Exportin 1).

D. Dean, Khatera Rahmani, 2017, Biochemical and biophysical research communications.

SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice.

Hongwei Yao, Wei Gu, Irfan Rahman, 2012, The Journal of clinical investigation.

Identification of differentially regulated genes in human patent ductus arteriosus

Michael F Swartz, D. Dean, Haiqing Bai, 2016, Experimental biology and medicine.

Caveolin-1 gene therapy inhibits inflammasome activation to protect from bleomycin-induced pulmonary fibrosis

P. Sime, D. Dean, Xin Lin, 2019, Scientific Reports.

Neonatal oxygen increases sensitivity to influenza A virus infection in adult mice by suppressing epithelial expression of Ear1.

S. Welle, M. O’Reilly, P. Keng, 2012, The American journal of pathology.

Gene Transfer of Interleukin 10 to the Murine Cornea Using Electroporation

D. Dean, R. Zhou, 2007, Experimental biology and medicine.

Nephron-deficient Fvb mice develop rapidly progressive renal failure and heavy albuminuria involving excess glomerular GLUT1 and VEGF

D. Deb, D. Dean, A. Chang, 2010, Laboratory Investigation.

In vivo rescue of recombinant Zika virus from an infectious cDNA clone and its implications in vaccine development

F. Almazán, D. Pérez, D. Dean, 2020, Scientific Reports.

Gene transfer of MRCKα rescues lipopolysaccharide-induced acute lung injury by restoring alveolar capillary barrier function

D. Dean, Jing Liu, 2021, Scientific reports.

Nondisruptive, sequence-specific coupling of fluorochromes to plasmid DNA.

D. Dean, E. Alton, F. Munkonge, 2006, Analytical biochemistry.

IL-13 Induces YY1 through the AKT Pathway in Lung Fibroblasts

Gang Liu, Hao-dong Xu, P. Sime, 2015, PloS one.

Intranuclear trafficking of episomal DNA is transcription-dependent.

J. Gasiorowski, D. Dean, 2007, Molecular therapy : the journal of the American Society of Gene Therapy.

Aleurain: a barley thiol protease closely related to mammalian cathepsin H.

G. Heck, D. Dean, J. Rogers, 1985, Proceedings of the National Academy of Sciences of the United States of America.

Essential role of the Vp2 and Vp3 DNA-binding domain in simian virus 40 morphogenesis

L. Lee, D. Dean, H. Kasamatsu, 1995, Journal of virology.

Cell-Specific Targeting Strategies for Electroporation-Mediated Gene Delivery in Cells and Animals

D. Dean, 2013, The Journal of Membrane Biology.

High‐level gene transfer to the cornea using electroporation

D. Dean, B. C. Weston, K. Blair-Parks, 2002, The journal of gene medicine.

Microinjecting cells using a pulsed-flow microinjection system.

J. Gasiorowski, D. Dean, 2011, Cold Spring Harbor protocols.

Store-operated calcium entry and increased endothelial cell permeability.

D. Dean, M. Li, T. Moore, 2000, American journal of physiology. Lung cellular and molecular physiology.

Hydroporation as the mechanism of hydrodynamic delivery

D. Stolz, J. Gasiorowski, D. Dean, 2004, Gene Therapy.

Progress and prospects: nuclear import of nonviral vectors

D. Dean, A. Lam, D A Dean, 2010, Gene Therapy.

Pol I transcription and pre-rRNA processing are coordinated in a transcription-dependent manner in mammalian cells.

J. Gasiorowski, D. Dean, D. Chen, 2006, Molecular biology of the cell.

Disruption of normal patterns of FOXF1 expression in a lethal disorder of lung development

Kristin M. Scheible, P. Stankiewicz, P. Szafranski, 2019, Journal of Medical Genetics.

Laminin-6 assembles into multimolecular fibrillar complexes with perlecan and participates in mechanical-signal transduction via a dystroglycan-dependent, integrin-independent mechanism

J. Sznajder, K. Campbell, E. Lecuona, 2005, Journal of Cell Science.

RNAi therapeutic strategies for acute respiratory distress syndrome

B. Nilsson, D. Dean, Arshad Rahman, 2019, Translational Research.

Intracellular trafficking of nucleic acids

D. Dean, R. C. Geiger, R. Zhou, 2004, Expert opinion on drug delivery.

Gene therapy: if at first you don't succeed...

D. Dean, R. Perkin, 2001, American family physician.

Targeted G-protein inhibition as a novel approach to decrease vagal atrial fibrillation by selective parasympathetic attenuation.

Jason Ng, Rishi Arora, Ivan Cokic, 2009, Cardiovascular research.

Nuclear entry of nonviral vectors

W. Zimmer, D. Dean, D A Dean, 2005, Gene Therapy.

Peptide nucleic acid (PNA) binding-mediated induction of human gamma- globin gene expression

Gan Wang, Steven R. Goodman, Xiaoxin Xu, 1999, Nucleic Acids Res..

Designed multi-domain protein as a carrier of nucleic acids into cells.

D. Dean, J. Xavier, V. Gopal, 2009, Journal of controlled release : official journal of the Controlled Release Society.

Regulation of the maltose transport system of Escherichia coli by the glucose-specific enzyme III of the phosphoenolpyruvate-sugar phosphotransferase system. Characterization of inducer exclusion-resistant mutants and reconstitution of inducer exclusion in proteoliposomes.

M. Saier, H. Nikaido, D. Dean, 1990, The Journal of biological chemistry.

Ambient particulate matter accelerates coagulation via an IL-6-dependent pathway.

J. Sznajder, J. Christman, G. Mutlu, 2007, The Journal of clinical investigation.

Nonviral gene transfer to skeletal, smooth, and cardiac muscle in living animals.

D. Dean, 2005, American journal of physiology. Cell physiology.

Calcium, ATP and nuclear pore channel gating

T. McDonnell, J. Hanover, J. Geibel, 2000, Pflügers Archiv.

Gene transfer of MRCKα rescues lipopolysaccharide-induced acute lung injury by restoring alveolar capillary barrier function

D. Dean, Jing Liu, 2021, Scientific Reports.

The Na+, K+-ATPase β1 subunit regulates epithelial tight junctions via MRCKα

D. Dean, Xin Lin, Haiqing Bai, 2021, JCI Insight.

The Na+, K+-ATPase β1 subunit regulates epithelial tight junctions via MRCKα

D. Dean, Xin Lin, Haiqing Bai, 2021, JCI insight.

Emerging significance of plasmid DNA nuclear import in gene therapy.

D. Dean, E. Alton, U. Griesenbach, 2003, Advanced drug delivery reviews.

Cell-specific nuclear import of plasmid DNA in smooth muscle requires tissue-specific transcription factors and DNA sequences

A. Miller, D. Dean, D A Dean, 2008, Gene Therapy.

Quantifying induced electric field strengths during gene transfer to the intact rat vasculature

Raji Sundararajan, David A. Dean, R. Sundararajan, 2009 .

Sequence requirements for plasmid nuclear import.

L. Smith, D. Dean, S. Muller, 1999, Experimental cell research.

Featured Article: Electroporation-mediated gene delivery of surfactant protein B (SP-B) restores expression and improves survival in mouse model of SP-B deficiency

K. L. de Mesy Bentley, D. Dean, Xin Lin, 2017, Experimental biology and medicine.

Determination of soya proteins in food using an enzyme‐linked immunosorbent assay procedure

F. J. Bailey, P. Davis, D. Dean, 1981 .

Active transport of maltose in membrane vesicles obtained from Escherichia coli cells producing tethered maltose-binding protein

H. Nikaido, K. Gehring, D. Dean, 1989, Journal of bacteriology.

Serine / threonine protein phosphatase 5 (PP5) participates in the regulation of glucocorticoid receptor nucleocytoplasmic shuttling

S. Rusconi, N. Dean, D. Dean, 2001, BMC Cell Biology.

Transcription factor plasmid binding modulates microtubule interactions and intracellular trafficking during gene transfer

D. Dean, E. Vaughan, M. Badding, 2011, Gene Therapy.

Electroporation-mediated transfer of plasmids to the lung results in reduced TLR9 signaling and inflammation

N. Zhang, D. Dean, J. Norton, 2007, Gene Therapy.

Early stabilizing alveolar ventilation prevents acute respiratory distress syndrome: A novel timing-based ventilatory intervention to avert lung injury

Y. Vodovotz, N. Habashi, D. Dean, 2012, The journal of trauma and acute care surgery.

Electroporation-Mediated Gene Delivery of Na+,K+-ATPase, and ENaC Subunits to the Lung Attenuates Acute Respiratory Distress Syndrome in a Two-Hit Porcine Model

D. Dean, G. Nieman, L. Gatto, 2015, Shock.

Electroporation-mediated gene transfer of the Na+,K+ -ATPase rescues endotoxin-induced lung injury.

G. Mutlu, D. Machado-Aranda, D. Urich, 2007, American journal of respiratory and critical care medicine.

Gene transfer of the Na+,K+-ATPase beta1 subunit using electroporation increases lung liquid clearance.

J. Sznajder, D. Machado-Aranda, D. Dean, 2005, American journal of respiratory and critical care medicine.

Cyclic stretch‐induced nuclear localization of transcription factors results in increased nuclear targeting of plasmids in alveolar epithelial cells

D. Dean, A. Lam, 2008, The journal of gene medicine.

The effects of cyclic stretch on gene transfer in alveolar epithelial cells.

M. Glucksberg, D. Dean, Erica Davis, 2003, Molecular therapy : the journal of the American Society of Gene Therapy.

The SP-C promoter facilitates alveolar type II epithelial cell-specific plasmid nuclear import and gene expression

D. Dean, James V. DeGiulio, C. D. Kaufman, 2010, Gene Therapy.

Smooth Muscle-Specific Gene Delivery in the Vasculature Based on Restriction of DNA Nuclear Import

W. Zimmer, D. Dean, Jennifer L Young, 2008, Experimental biology and medicine.

Epithelial ablation of Bcl-XL increases sensitivity to oxygen without disrupting lung development.

M. O’Reilly, R. Staversky, D. Dean, 2010, American journal of respiratory cell and molecular biology.

Electrotransfer of Plasmid DNA

M. Rols, J. Escoffre, D. Dean, 2011 .

Transforming Growth Factor- (cid:1) Induction of Smooth Muscle Cell Phenotpye Requires Transcriptional and Post-transcriptional Control of Serum Response Factor*

R. Schwartz, K. Hirschi, W. Zimmer, 2022 .

Modulation of protein kinase C (PKC)-mediated contraction and the possible role of PKC epsilon in rat mesenteric arteries.

D. Dean, Y. Shirasawa, Jennifer L. Young, 2003, Frontiers in bioscience : a journal and virtual library.

Tubulin acetylation and histone deacetylase 6 activity in the lung under cyclic load.

D. Dean, R. C. Geiger, G. Budinger, 2009, American journal of respiratory cell and molecular biology.

Electroporation as a method for high-level nonviral gene transfer to the lung

D. Machado-Aranda, D. Dean, A. Yeldandi, 2003, Gene Therapy.

Maltose transport in membrane vesicles of Escherichia coli is linked to ATP hydrolysis.

H. Nikaido, D. Dean, A. Davidson, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Functional Delivery of siRNA by Disulfide-Constrained Cyclic Amphipathic Peptides.

B. Nilsson, D. Dean, Ria J Swanekamp, 2016, ACS medicinal chemistry letters.

Interaction between maltose‐binding protein and the membrane‐associated maltose transporter complex in Escherichia coli

H. Nikaido, L. Hor, D. Dean, 1992, Molecular microbiology.

Critical role of autophagy regulator Beclin1 in endothelial cell inflammation and barrier disruption.

D. Dean, S. Slavin, F. Fazal, 2019, Cellular signalling.

Cyclic stretch of alveolar epithelial cells alters cytoskeletal micromechanics

D. Dean, Mootaz Eldib, 2011, Biotechnology and bioengineering.

Muscle-specific enhancement of gene expression by incorporation of SV40 enhancer in the expression plasmid

M. Gondo, D. Dean, J. Fewell, 2001, Gene Therapy.

Mechanisms of nuclear transport and interventions.

J. Gasiorowski, D. Dean, 2003, Advanced drug delivery reviews.

The role of ATP as the energy source for maltose transport in Escherichia coli.

H. Nikaido, D. Dean, A. Davidson, 1990, Research in microbiology.

Intracellular trafficking of plasmids during transfection is mediated by microtubules.

D. Dean, E. Vaughan, 2006, Molecular therapy : the journal of the American Society of Gene Therapy.

Gene Transfer to Intact Mesenteric Arteries by Electroporation

David A. Dean, D. Dean, Jason B. Martin, 2000, Journal of Vascular Research.

Synthesis and Application of Peptide-siRNA Nanoparticles from Disulfide-Constrained Cyclic Amphipathic Peptides for the Functional Delivery of Therapeutic Oligonucleotides to the Lung.

B. Nilsson, D. Dean, Jade J Welch, 2021, Methods in molecular biology.

Electroporation of the vasculature and the lung.

D. Dean, David A Dean, 2003, DNA and cell biology.

Cyclic stretch-induced reorganization of the cytoskeleton and its role in enhanced gene transfer

M. Glucksberg, D. Dean, R. C. Geiger, 2006, Gene Therapy.

Resistance of Drosophila to cadmium: biochemical factors in resistant and sensitive strains.

K. Jacobson, D. Dean, H. Gill, 1989, Toxicology.

Changes in lung immune cell infiltrates after electric field treatment in mice

S. Georas, D. Dean, T. Chapman, 2021, Scientific reports.

Modulation of membrane traffic by mechanical stimuli

M. Emmer, Vimalkumar A. Patel, W. Paulus, 2001 .

Nuclear targeting of plasmid DNA in human corneal cells.

D. Dean, B. Dean, J. N. Byrd, 1999, Current eye research.

Electroporation-Mediated Gene Delivery of Na+,K+-ATPase, and ENaC Subunits to the Lung Attenuates Acute Respiratory Distress Syndrome in a Two-Hit Porcine Model

D. Dean, G. Nieman, L. Gatto, 2015, Shock.

Electroporation-mediated delivery of catalytic oligodeoxynucleotides for manipulation of vascular gene expression.

D. Dean, Y. Shirasawa, J. Benoit, 2003, American journal of physiology. Heart and circulatory physiology.

Featured Article: Electroporation-mediated gene delivery of surfactant protein B (SP-B) restores expression and improves survival in mouse model of SP-B deficiency

K. L. de Mesy Bentley, D. Dean, Xin Lin, 2017, Experimental biology and medicine.