E. Canalis

发表

Transgenic mice expressing selected insulin-like growth factor-binding protein-5 fragments do not exhibit enhanced bone formation.

D. Durant, R. Pereira, L. Stadmeyer, 2004, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.

Skeletal overexpression of noggin results in osteopenia and reduced bone formation.

A. Economides, R. Pereira, E. Canalis, 2003, Endocrinology.

Transgenic mice overexpressing insulin-like growth factor binding protein-5 display transiently decreased osteoblastic function and osteopenia.

E. Canalis, R. Devlin, Z. Du, 2002, Endocrinology.

Mary L Bouxsein, Vaida Glatt, M. Bouxsein, 2007, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Notch1 and Notch2 expression in osteoblast precursors regulates femoral microarchitecture.

E. Canalis, Stefano Zanotti, Ernesto Canalis, 2014, Bone.

Nuclear Factor of Activated T-cells (NFAT)c2 Inhibits Notch Receptor Signaling in Osteoblasts*

E. Canalis, S. Zanotti, A. Smerdel-Ramoya, 2012, The Journal of Biological Chemistry.

Connective tissue growth factor is required for skeletal development and postnatal skeletal homeostasis in male mice.

A. Economides, E. Canalis, W. Beamer, 2010, Endocrinology.

Activated alveolar epithelial cells initiate fibrosis through autocrine and paracrine secretion of connective tissue growth factor.

J. Horowitz, E. Canalis, Kevin K. Kim, 2014, American journal of physiology. Lung cellular and molecular physiology.

and Paracrine Secretion of Connective Tissue Growth Factor

J. Horowitz, E. Canalis, Kevin K. Kim, 2014 .

Interleukin 6 is autoregulated by transcriptional mechanisms in cultures of rat osteoblastic cells.

N. Franchimont, E. Canalis, S. Rydziel, 1997, The Journal of clinical investigation.

Gremlin1 is required for skeletal development and postnatal skeletal homeostasis

E. Canalis, S. Zanotti, Kristen Parker, 2012, Journal of cellular physiology.

Conditional Deletion of Gremlin Causes a Transient Increase in Bone Formation and Bone Mass*

A. Economides, D. Durant, L. Stadmeyer, 2007, Journal of Biological Chemistry.

Cortisol Increases Interstitial Collagenase Expression in Osteoblasts by Post-transcriptional Mechanisms (*)

E. Canalis, J. Jeffrey, A. Delany, 1995, The Journal of Biological Chemistry.

PPARG by Dietary Fat Interaction Influences Bone Mass in Mice and Humans

D. Kiel, G. Churchill, M. Bouxsein, 2008, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Deficiency of Sef Is Associated With Increased Postnatal Cortical Bone Mass by Regulating Runx2 Activity

C. Rosen, E. Canalis, R. Friesel, 2014, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

CCAAT/enhancer binding protein homologous protein (DDIT3) induces osteoblastic cell differentiation.

R. Pereira, E. Canalis, A. Delany, 2004, Endocrinology.

The Heparin-binding Domain of IGFBP-2 Has Insulin-like Growth Factor Binding-independent Biologic Activity in the Growing Skeleton*

M. Bouxsein, A. Breggia, D. Clemmons, 2011, The Journal of Biological Chemistry.

Local regulators of skeletal growth: a perspective.

E. Canalis, M. Centrella, 1985, Endocrine reviews.

Human platelet-derived transforming growth factor-beta stimulates parameters of bone growth in fetal rat calvariae.

J. Massagué, E. Canalis, M. Centrella, 1986, Endocrinology.

Insulin like growth factors and the local regulation of bone formation.

E. Canalis, 1992, Bone.

Serum IGF‐1 Determines Skeletal Strength by Regulating Subperiosteal Expansion and Trait Interactions

M. Bouxsein, S. Yakar, K. Jepsen, 2009, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Nemo‐Like Kinase Regulates Postnatal Skeletal Homeostasis

E. Canalis, S. Zanotti, L. Kranz, 2014, Journal of cellular physiology.

Interleukin-6 and Its Soluble Receptor Cause a Marked Induction of Collagenase 3 Expression in Rat Osteoblast Cultures*

N. Franchimont, E. Canalis, A. Delany, 1997, The Journal of Biological Chemistry.

Platelet-derived growth factor enhances bone cell replication, but not differentiated function of osteoblasts.

E. Canalis, J. Hock, E. Canalis, 1994, Endocrinology.

Osteoblast lineage-specific effects of notch activation in the skeleton.

Jian Q. Feng, E. Canalis, S. Zanotti, 2013, Endocrinology.

Notch Signaling in Osteocytes Differentially Regulates Cancellous and Cortical Bone Remodeling*

A. Boskey, E. Canalis, S. Zanotti, 2013, The Journal of Biological Chemistry.

Regulates Cancellous and Cortical Bone Notch Signaling in Osteocytes Differentially Molecular Bases of Disease :

Adèle, E. Canalis, S. Zanotti, 2013 .

Tumor necrosis factor-alpha inhibits collagen synthesis and alkaline phosphatase activity independently of its effect on deoxyribonucleic acid synthesis in osteoblast-enriched bone cell cultures.

E. Canalis, M. Centrella, T. McCarthy, 1988, Endocrinology.

Nephroblastoma overexpressed (Nov) induces gremlin in ST‐2 stromal cell lines by post‐transcriptional mechanisms

E. Canalis, S. Zanotti, A. Smerdel-Ramoya, 2011, Journal of cellular biochemistry.

Bone Morphogenetic Proteins Induce Gremlin, a Protein That Limits Their Activity in Osteoblasts1

A. Economides, R. Pereira, E. Canalis, 2000 .

Bone morphogenetic proteins induce gremlin, a protein that limits their activity in osteoblasts.

A. Economides, R. Pereira, E. Canalis, 2000, Endocrinology.

Platelet-Derived Growth Factor and the Skeleton

E. Canalis, 2008 .

Chapter 46 – Platelet-Derived Growth Factor and the Skeleton

E. Canalis, S. Rydziel, 2002 .

Glucocorticoid-induced osteoporosis: clinical and therapeutic aspects.

J. Bilezikian, G. Mazziotti, E. Canalis, 2007, Arquivos brasileiros de endocrinologia e metabologia.

Glucocorticoid-induced osteoporosis: pathophysiology and therapy

J. Bilezikian, G. Mazziotti, E. Canalis, 2007, Osteoporosis International.

Skeletal Effects of Glucocorticoids: Basic and Clinical Aspects

E. Canalis, 2005 .

Perspectives on glucocorticoid-induced osteoporosis.

J. Bilezikian, E. Canalis, A. Giustina, 2004, Bone.

Mechanisms of glucocorticoid-induced osteoporosis.

E. Canalis, 2003 .

11β‐Hydroxysteroid Dehydrogenase, an Amplifier of Glucocorticoid Action in Osteoblasts

E. Canalis, A. Delany, 2002, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Clinical review 83: Mechanisms of glucocorticoid action in bone: implications to glucocorticoid-induced osteoporosis.

E. Canalis, 1996, The Journal of clinical endocrinology and metabolism.

Insulin-like growth factor (IGF) and bone.

E. Canalis, M. Centrella, T. McCarthy, 1989, Connective tissue research.

Skeletal actions of insulin-like growth factors

E. Canalis, E. Gazzerro, 2006, Expert review of endocrinology & metabolism.

Insulin-like growth factor I has independent effects on bone matrix formation and cell replication.

E. Canalis, M. Centrella, J. Hock, 1988, Endocrinology.

Activin-A binding and biochemical effects in osteoblast-enriched cultures from fetal-rat parietal bone

E. Canalis, M. Centrella, T. McCarthy, 1991, Molecular and cellular biology.

Osteonectin-null mutation compromises osteoblast formation, maturation, and survival.

I. Kalajzic, E. Sage, E. Canalis, 2003, Endocrinology.

A soluble activin Type IIA receptor induces bone formation and improves skeletal integrity

M. Bouxsein, A. Grinberg, L. Stadmeyer, 2008, Proceedings of the National Academy of Sciences.

Effect of fibroblast growth factor on cultured fetal rat calvaria.

E. Canalis, L. Raisz, 1980, Metabolism: clinical and experimental.

Triiodothyronine induces collagenase-3 and gelatinase B expression in murine osteoblasts.

R. Pereira, E. Canalis, V. Jorgetti, 1999, The American journal of physiology.

The ternary IGF complex influences postnatal bone acquisition and the skeletal response to intermittent parathyroid hormone.

M. Bouxsein, P. Cohen, D. Leroith, 2006, The Journal of endocrinology.

Insulin-like growth factors and osteoporosis.

E. Canalis, 1997, Bone.

Abnormal gonadotropin secretory responses to LRH in transsexual women after diethylstilbestrol priming.

E. Canalis, S. Reichlin, L. Seyler, 1978, The Journal of clinical endocrinology and metabolism.

Skeletal overexpression of gremlin impairs bone formation and causes osteopenia.

A. Economides, R. Pereira, E. Canalis, 2005, Endocrinology.

Gender-specific changes in bone turnover and skeletal architecture in igfbp-2-null mice.

M. Bouxsein, T. Wood, D. Clemmons, 2008, Endocrinology.

Loss of Gremlin Delays Primordial Follicle Assembly but Does Not Affect Female Fertility in Mice1

A. Economides, S. Pangas, E. Canalis, 2011, Biology of reproduction.

Bone morphogenetic proteins induce the expression of noggin, which limits their activity in cultured rat osteoblasts.

E. Canalis, E. Gazzerro, V. Gangji, 1998, The Journal of clinical investigation.

Recombinant transforming growth factor type beta 3: biological activities and receptor-binding properties in isolated bone cells

E. Canalis, P. ten Dijke, M. Centrella, 1990, Molecular and cellular biology.

Effects of cortisol and bone morphogenetic protein-2 on stromal cell differentiation: correlation with CCAAT-enhancer binding protein expression.

R. Pereira, E. Canalis, A. Delany, 2002, Bone.

Parathyroid hormone increases mac25/insulin-like growth factor-binding protein-related protein-1 expression in cultured osteoblasts.

R. Pereira, E. Canalis, 1999, Endocrinology.

Cortisol Enhances the Expression of mac25/Insulin-Like Growth Factor-Binding Protein-Related Protein-1 in Cultured Osteoblasts* *This work was supported by NIDDK Grant DK-45227 and a scholarship (to R.C.P.) from Fundação Coordenação de Aperfeiçoa mento de Pessoal de Nível Superior (CAPES), Uni

R. Pereira, E. Canalis, F. Blanquaert, 1999, Endocrinology.

Cortisol enhances the expression of mac25/insulin-like growth factor-binding protein-related protein-1 in cultured osteoblasts.

E. Canalis, F. Blanquaert, R. C. Pereira, 1999, Endocrinology.

Insulin-like growth factor II promoter expression in cultured rodent osteoblasts and adult rat bone.

E. Canalis, V. Gangji, S. Rydziel, 1998, Endocrinology.

Growth factor regulation of insulin‐like growth factor binding protein‐6 expression in osteoblasts

E. Canalis, B. Gabbitas, 1997, Journal of cellular biochemistry.

Retinoic acid stimulates the transcription of insulin‐like growth factor binding protein‐6 in skeletal cells

E. Canalis, B. Gabbitas, 1996, Journal of cellular physiology.

C/EBP homologous protein is necessary for normal osteoblastic function

D. Ron, R. Pereira, L. Stadmeyer, 2006, Journal of cellular biochemistry.

CCAAT/Enhancer-binding protein homologous protein (CHOP) decreases bone formation and causes osteopenia.

R. Pereira, L. Stadmeyer, E. Canalis, 2007, Bone.

Basic fibroblast growth factor stimulates expression of interstitial collagenase and inhibitors of metalloproteinases in rat bone cells.

E. Canalis, J. Jeffrey, M. Ramsby, 1995, Endocrinology.

Nuclear factor of activated T cells 1 and 2 are required for vertebral homeostasis

E. Canalis, Jungeun Yu, L. Schilling, 2020, Journal of cellular physiology.

Protease-Activated Receptor 1 Deletion Causes Enhanced Osteoclastogenesis in Response to Inflammatory Signals through a Notch2-Dependent Mechanism

A. Sanjay, H. Drissi, E. Canalis, 2019, The Journal of Immunology.

Conditional inactivation of noggin in the postnatal skeleton causes osteopenia.

E. Canalis, S. Zanotti, Kristen Parker, 2012, Endocrinology.

HES1 (Hairy and Enhancer of Split 1) Is a Determinant of Bone Mass*

E. Canalis, S. Zanotti, A. Smerdel-Ramoya, 2010, The Journal of Biological Chemistry.

Nephroblastoma overexpressed (Nov) inactivation sensitizes osteoblasts to bone morphogenetic protein-2, but nov is dispensable for skeletal homeostasis.

A. Economides, D. Durant, E. Canalis, 2010, Endocrinology.

Misexpression of CCAAT/enhancer binding protein beta causes osteopenia.

D. Durant, L. Stadmeyer, E. Canalis, 2009, The Journal of endocrinology.

Skeletal overexpression of connective tissue growth factor impairs bone formation and causes osteopenia.

D. Durant, L. Stadmeyer, E. Canalis, 2008, Endocrinology.

The mutation ROR2W749X, linked to human BDB, is a recessive mutation in the mouse, causing brachydactyly, mediating patterning of joints and modeling recessive Robinow syndrome

S. Mundlos, G. Yancopoulos, M. Sleeman, 2008, Development.

Nephroblastoma Overexpressed (Nov) Inhibits Osteoblastogenesis and Causes Osteopenia*

D. Durant, L. Stadmeyer, E. Canalis, 2007, Journal of Biological Chemistry.

Twisted gastrulation, a bone morphogenetic protein agonist/antagonist, is not required for post-natal skeletal function.

A. Economides, L. Stadmeyer, E. Canalis, 2006, Bone.

Effects of bone associated growth factors on DNA, collagen and osteocalcin synthesis in cultured fetal rat calvariae.

J. Lian, E. Canalis, 1988, Bone.

Novel treatments for osteoporosis.

E. Canalis, 2000, The Journal of clinical investigation.

New treatment modalities in osteoporosis.

E. Canalis, 2010, Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists.

Drug-induced osteoporosis: mechanisms and clinical implications.

G. Mazziotti, E. Canalis, A. Giustina, 2010, The American journal of medicine.

NOVEL ANABOLIC TREATMENTS FOR OSTEOPOROSIS

E. Canalis, 2017 .

Glucocorticoid-induced osteoporosis: summary of a workshop.

E. Canalis, A. Giustina, E. Canalis, 2001, The Journal of clinical endocrinology and metabolism.

Management of glucocorticoid induced osteoporosis in premenopausal women with autoimmune disease.

N. Franchimont, E. Canalis, 2003, Autoimmunity reviews.

Effects of endothelial cell growth factor on bone remodelling in vitro.

E. Canalis, T. Maciag, W. Burgess, 1987, The Journal of clinical investigation.

Direct stimulation of bone resorption by epidermal growth factor.

E. Canalis, A. Sandberg, L. Raisz, 1980, Endocrinology.

Fibroblast growth factor-2 induces hepatocyte growth factor/scatter factor expression in osteoblasts.

E. Canalis, A. Delany, F. Blanquaert, 1999, Endocrinology.

Glucocorticoid regulation of transforming growth factor beta 1 activity and binding in osteoblast-enriched cultures from fetal rat bone

E. Canalis, M. Centrella, T. McCarthy, 1991, Molecular and cellular biology.

Characterization of the effect of insulin on collagen synthesis in fetal rat bone.

E. Canalis, B. Kream, L. Raisz, 1985, Endocrinology.

Hormonal regulation of bone formation.

E. Canalis, B. Kream, L. Raisz, 1978, Recent progress in hormone research.

Treatment of glucocorticoid-induced osteoporosis

J. Bilezikian, G. Mazziotti, E. Canalis, 2009, Therapeutic advances in musculoskeletal disease.

AU-Rich Elements in the Collagenase 3 mRNA Mediate Stabilization of the Transcript by Cortisol in Osteoblasts*

E. Canalis, A. Delany, S. Rydziel, 2004, Journal of Biological Chemistry.

The cellular and molecular basis of glucocorticoid actions in bone.

R. Pereira, E. Canalis, A. Delany, 2002, Frontiers of hormone research.

Mechanisms of glucocorticoid action in bone

E. Canalis, 2005, Annals of the New York Academy of Sciences.

Cortisol inhibits the differentiation and apoptosis of osteoblasts in culture.

E. Canalis, A. Delany, R. M. Pereira, 2001, Bone.

Cortisol inhibits hepatocyte growth factor/scatter factor expression and induces c-met transcripts in osteoblasts.

R. Pereira, E. Canalis, F. Blanquaert, 2000, American journal of physiology. Endocrinology and metabolism.

Glucocorticoid-induced osteoporosis

E. Canalis, 2000, Oxford Textbook of Endocrinology and Diabetes 3e.

Differential effects of warfarin on mRNA levels of developmentally regulated vitamin K dependent proteins, osteocalcin, and matrix Gla protein in vitro

G. Stein, J. Lian, E. Canalis, 1994, Journal of cellular physiology.

Skeletal disorders associated with the growth hormone–insulin-like growth factor 1 axis

G. Mazziotti, E. Canalis, A. Lania, 2022, Nature Reviews Endocrinology.

Overexpression of insulin-like growth factor binding protein-5 decreases osteoblastic function in vitro.

D. Durant, E. Canalis, R. M. Pereira, 2004, Bone.

Noggin arrests stromal cell differentiation in vitro.

A. Economides, E. Canalis, R. Devlin, 2003, Bone.

Cyclic AMP induces insulin-like growth factor I synthesis in osteoblast-enriched cultures.

E. Canalis, M. Centrella, T. McCarthy, 1990, The Journal of biological chemistry.

Complex pattern of insulin‐like growth factor binding protein expression in primary rat osteoblast enriched cultures: Regulation by prostaglandin E2, growth hormone, and the insulin‐like growth factors

E. Canalis, M. Centrella, T. McCarthy, 1994, Journal of cellular physiology.

Prostaglandin E2 stimulates insulin-like growth factor I synthesis in osteoblast-enriched cultures from fetal rat bone.

E. Canalis, M. Centrella, T. McCarthy, 1991, Endocrinology.

Insulin-like growth factor (IGF) I and retinoic acid induce the synthesis of IGF-binding protein 5 in rat osteoblastic cells.

E. Canalis, Y. Dong, Yu Dong, 1995, Endocrinology.

Skeletal Growth Factors Regulate the Synthesis of Insulin-like Growth Factor Binding Protein-5 in Bone Cell Cultures (*)

E. Canalis, B. Gabbitas, 1995, The Journal of Biological Chemistry.

Skeletal growth factors and aging.

E. Canalis, 1994, The Journal of clinical endocrinology and metabolism.

Bone morphogenetic protein-2 inhibits the synthesis of insulin-like growth factor-binding protein-5 in bone cell cultures.

E. Canalis, B. Gabbitas, 1995, Endocrinology.

Hormonal control of bone collagen synthesis in vitro: effects of parathyroid hormone and calcitonin.

E. Canalis, D. Maina, L. Raisz, 1976, Endocrinology.

Isoform-specific regulation of platelet-derived growth factor activity and binding in osteoblast-enriched cultures from fetal rat bone.

E. Canalis, M. Centrella, T. McCarthy, 1992, The Journal of clinical investigation.

Cellular and clinical perspectives on skeletal insulin‐like growth factor I

E. Canalis, A. Delany, J. Pash, 1994, Journal of cellular biochemistry.

Further biochemical and molecular characterization of primary rat parietal bone cell cultures

E. Canalis, M. Centrella, T. McCarthy, 1988, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Insulin-like growth factors inhibit interstitial collagenase synthesis in bone cell cultures.

E. Canalis, J. Jeffrey, A. Delany, 1995, Endocrinology.

Basic fibroblast growth factor destabilizes osteonectin mRNA in osteoblasts.

E. Canalis, A. Delany, 1998, American journal of physiology. Cell physiology.

Igfbp2 Deletion in Ovariectomized Mice Enhances Energy Expenditure but Accelerates Bone Loss.

R. Baron, D. Clemmons, C. Rosen, 2015, Endocrinology.

Regulatory effects of insulin-like growth factors I and II on bone collagen synthesis in rat calvarial cultures.

E. Canalis, M. Centrella, T. McCarthy, 1989, Endocrinology.

Effect of platelet-derived growth factor on DNA and protein synthesis in cultured rat calvaria.

E. Canalis, 1981, Metabolism: clinical and experimental.

Effects of tumor necrosis factor on bone formation in vitro.

E. Canalis, 1987, Endocrinology.

Cortisol inhibits the synthesis of insulin-like growth factor-I in skeletal cells.

E. Canalis, M. Centrella, T. McCarthy, 1990, Endocrinology.

Determination and expression of platelet-derived growth factor-AA in bone cell cultures.

C. Ladd, E. Canalis, M. Centrella, 1992, Endocrinology.

Isolation and characterization of insulin-like growth factor I (somatomedin-C) from cultures of fetal rat calvariae.

E. Canalis, M. Centrella, T. McCarthy, 1988, Endocrinology.

Fibroblast growth factor-2 induces hepatocyte growth factor/scatter factor expression in osteoblasts.

E. Canalis, A. Delany, F. Blanquaert, 1999, Endocrinology.

Notch 1 Overexpression Inhibits Osteoblastogenesis by Suppressing Wnt/β-Catenin but Not Bone Morphogenetic Protein Signaling*

E. Canalis, E. Gazzerro, S. Rydziel, 2006, Journal of Biological Chemistry.

The fate of circulating osteoblasts.

E. Canalis, 2005, The New England journal of medicine.

Glucocorticoid‐induced osteoporosis in rheumatic diseases

R. Pereira, E. Canalis, J. D. de Carvalho, 2010, Clinics.

Dual Regulation of Stromelysin-3 by Fibroblast Growth Factor-2 in Murine Osteoblasts*

E. Canalis, A. Delany, 1998, The Journal of Biological Chemistry.

Use of antisense oligonucleotides to target Notch3 in skeletal cells

E. Canalis, M. Carrer, Jungeun Yu, 2022, PloS one.

Regulation of insulin‐like growth factors I and II and their binding proteins in human bone marrow stromal cells by dexamethasone

S. Mohan, F. Lecanda, Su‐Li Cheng, 1998, Journal of cellular biochemistry.

ENDOCRINOLOGY IN THE TIME OF COVID-19: Management of calcium metabolic disorders and osteoporosis

L. Rejnmark, J. Bollerslev, E. Canalis, 2020, European journal of endocrinology.

Novel signals determining skeletal cell fate and function

R. Pereira, E. Canalis, E. Gazzerro, 2016 .

Effect of sodium vanadate on deoxyribonucleic acid and protein syntheses in cultured rat calvariae.

E. Canalis, 1985, Endocrinology.

Growth factors regulate the synthesis of insulin-like growth factor-I in bone cell cultures.

E. Canalis, S. Rydziel, B. Gabbitas, 1993, Endocrinology.

Osteopenia and decreased bone formation in osteonectin-deficient mice.

R. Baron, M. Amling, E. Canalis, 2000, The Journal of clinical investigation.

1,25-Dihydroxyvitamin D3 effects on collagen and DNA synthesis in periosteum and periosteum-free calvaria.

J. Lian, E. Canalis, 1985, Bone.

Hormonal control of bone collagen synthesis in vitro: inhibitory effect of 1-hydroxylated vitamin D metabolites.

E. Canalis, D. Maina, L. Raisz, 1978, Endocrinology.

Transcriptional regulation of connective tissue growth factor by cortisol in osteoblasts.

D. Durant, R. Pereira, E. Canalis, 2000, American journal of physiology. Endocrinology and metabolism.

Expression and regulation of CCN genes in murine osteoblasts.

E. Canalis, S. Rydziel, M. Parisi, 2006, Bone.

Connective tissue growth factor is a target of notch signaling in cells of the osteoblastic lineage.

E. Canalis, S. Zanotti, A. Smerdel-Ramoya, 2014, Bone.

Connective tissue growth factor (CTGF) transactivates nuclear factor of activated T‐cells (NFAT) in cells of the osteoblastic lineage

E. Canalis, S. Zanotti, A. Smerdel-Ramoya, 2010, Journal of cellular biochemistry.

Role of Insulin-Like Growth Factor I And II on Skeletal Remodeling

E. Canalis, M. Centrella, T. McCarthy, 1989 .

Notch suppresses nuclear factor of activated T cells (NFAT) transactivation and Nfatc1 expression in chondrocytes.

E. Canalis, S. Zanotti, 2013, Endocrinology.

Reciprocal Regulation of Notch and Nuclear Factor of Activated T-cells (NFAT) c1 Transactivation in Osteoblasts*

E. Canalis, S. Zanotti, A. Smerdel-Ramoya, 2010, The Journal of Biological Chemistry.

Insulin-like growth factors sustain insulin-like growth factor-binding protein-5 expression in osteoblasts.

E. Canalis, B. Gabbitas, 1998, American journal of physiology. Endocrinology and metabolism.

Interleukin-6 and its soluble receptor regulate the expression of insulin-like growth factor binding protein-5 in osteoblast cultures.

N. Franchimont, D. Durant, E. Canalis, 1997, Endocrinology.

Transcriptional regulation of insulin-like growth factor-binding protein-5 by prostaglandin E2 in osteoblast cells.

E. Canalis, J. Pash, 1996, Endocrinology.

Editorial: Inhibitory Actions of Glucocorticoids on Skeletal Growth. Is Local Insulin-Like Growth Factor I to Blame?

E. Canalis, 1998, Endocrinology.

Inhibitory actions of glucocorticoids on skeletal growth. Is local insulin-like growth factor I to blame?

E. Canalis, 1998, Endocrinology.

Studies of hormonal regulation of osteocalcin synthesis in cultured fetal rat calvariae.

J. Lian, E. Canalis, M. Coutts, 1985, The Journal of biological chemistry.

Glucocorticoid-induced osteoporosis: an update

J. Bilezikian, G. Mazziotti, E. Canalis, 2006, Trends in Endocrinology & Metabolism.

Bone morphogenetic protein 2 increases insulin‐like growth factor I and II transcripts and polypeptide levels in bone cell cultures

E. Canalis, B. Gabbitas, 1994, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Platelet-derived Growth Factor Induces Interleukin-6 Transcription in Osteoblasts through the Activator Protein-1 Complex and Activating Transcription Factor-2*

N. Franchimont, D. Durant, E. Canalis, 1999, The Journal of Biological Chemistry.

Gene delivery by retroviruses.

E. Canalis, V. Deregowski, 2008, Methods in molecular biology.

The role of growth factors in skeletal remodeling.

E. Canalis, M. Centrella, T. McCarthy, 1989, Endocrinology and metabolism clinics of North America.

Clinical review 35: Growth factors and their potential clinical value.

E. Canalis, E. Canalis, 1992, The Journal of clinical endocrinology and metabolism.

Transforming Growth Factor-β Stimulates Bone Matrix Apposition and Bone Cell Replication in Cultured Fetal Rat Calvariae*

E. Canalis, M. Centrella, J. Hock, 1990 .

Regulation of collagenase-3 by bone morphogenetic protein-2 in bone cell cultures.

E. Canalis, S. Varghese, 1997, Endocrinology.

Leukemia inhibitory factor and oncostatin M stimulate collagenase-3 expression in osteoblasts.

E. Canalis, S. Varghese, Kyung-Ae Yu, 1999, American journal of physiology. Endocrinology and metabolism.

Transgenic Overexpression of Gremlin Results in Developmental Defects in Enamel and Dentin in Mice

M. Somerman, L. Stadmeyer, E. Canalis, 2008, Connective tissue research.

Growth factors and cytokines in bone cell metabolism.

E. Canalis, M. Centrella, T. McCarthy, 1991, Annual review of medicine.

A bone-derived growth factor isolated from rat calvariae is beta 2 microglobulin.

E. Canalis, M. Centrella, T. McCarthy, 1987, Endocrinology.

Transforming and nontransforming growth factors are present in medium conditioned by fetal rat calvariae.

E. Canalis, M. Centrella, 1985, Proceedings of the National Academy of Sciences of the United States of America.

Regulation of interstitial collagenase expression and collagen degradation by retinoic acid in bone cells.

E. Canalis, J. Jeffrey, S. Rydziel, 1994, Endocrinology.

Cortisol enhances the transcription of insulin-like growth factor-binding protein-6 in cultured osteoblasts.

E. Canalis, B. Gabbitas, 1996, Endocrinology.

Effects of deflazacort on aspects of bone formation in cultures of intact calvariae and osteoblast‐enriched cells

L. Avioli, E. Canalis, Louis Avioli, 1992, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Interleukin-6 with its soluble receptor enhances the expression of insulin-like growth factor-I in osteoblasts.

N. Franchimont, D. Durant, E. Canalis, 1997, Endocrinology.

Platelet-derived growth factor stimulates the synthesis of interleukin-6 in cells of the osteoblast lineage.

N. Franchimont, E. Canalis, 1995, Endocrinology.

Effects of fibroblast growth factors on deoxyribonucleic acid and collagen synthesis in rat parietal bone cells.

E. Canalis, M. Centrella, T. McCarthy, 1989, Endocrinology.

Receptors for insulin-like growth factors-I and -II in osteoblast-enriched cultures from fetal rat bone.

E. Canalis, M. Centrella, T. McCarthy, 1990, Endocrinology.

Hormonal control of bone collagen synthesis in vitro. Effects of insulin and glucagon.

E. Canalis, D. Maina, L. Raisz, 1977, Endocrinology.

Growth Factors, Bone Metabolism, and Metabolic Bone Diseases

E. Canalis, 1996 .

Cortisol represses insulin-like growth factor II receptor transcription in skeletal cell cultures.

E. Canalis, S. Rydziel, 1995, Endocrinology.

Regulation of insulin-like growth factor-II synthesis in bone cell cultures by skeletal growth factors.

E. Canalis, B. Gabbitas, J. Pash, 1994, Endocrinology.

Constitutive synthesis of insulin-like growth factor-II by primary osteoblast-enriched cultures from fetal rat calvariae.

E. Canalis, M. Centrella, T. McCarthy, 1992, Endocrinology.

Systemic and local factors and the maintenance of bone quality

E. Canalis, 2005, Calcified Tissue International.

Cortisol downregulates osteoblast α1(I) procollagen mRNA by transcriptional and posttranscriptional mechanisms

E. Canalis, A. Delany, B. Gabbitas, 1995 .

Mechanisms of glucocorticoid action in bone cells

E. Canalis, A. Delany, Yu Dong, 1994, Journal of cellular biochemistry.

Effect of sex steroids on bone collagen synthesis in vitro

E. Canalis, L. Raisz, 1978, Calcified Tissue Research.

CHAPTER 11 – Parathyroid Hormone: Anabolic and Catabolic Effects on Bone and Interactions with Growth Factors

E. Canalis, J. Hock, L. Raisz, 2001 .

Effect of somatomedin and growth hormone on bone collagen synthesis in vitro.

E. Canalis, D. Maina, R. Hintz, 1977, Metabolism: clinical and experimental.

Effect of hormones and growth factors on alkaline phosphatase activity and collagen synthesis in cultured rat calvariae.

E. Canalis, 1983, Metabolism: clinical and experimental.

Effects of glucocorticoids on fetal rat bone collagen synthesis in vitro.

E. Canalis, D. Maina, L. Raisz, 1979, Endocrinology.

Platelet-derived growth factor enhances deoxyribonucleic acid and collagen synthesis in osteoblast-enriched cultures from fetal rat parietal bone.

E. Canalis, M. Centrella, T. McCarthy, 1989, Endocrinology.

Interleukin-1 has independent effects on deoxyribonucleic acid and collagen synthesis in cultures of rat calvariae.

E. Canalis, 1986, Endocrinology.

Transforming growth factor beta is a bifunctional regulator of replication and collagen synthesis in osteoblast-enriched cell cultures from fetal rat bone.

E. Canalis, M. Centrella, T. McCarthy, 1987, The Journal of biological chemistry.

Glucocorticoid-induced osteoporosis and parathyroid hormone.

J. Bilezikian, G. Mazziotti, E. Canalis, 2010, Journal of endocrinological investigation.

Transcriptional and posttranscriptional regulation of interstitial collagenase by platelet-derived growth factor BB in bone cell cultures.

E. Canalis, J. Jeffrey, A. Delany, 1996, Endocrinology.

Platelet-derived growth factor-AA and -BB (PDGF-AA and -BB) enhance the synthesis of PDGF-AA in bone cell cultures.

E. Canalis, S. Rydziel, S. Shaikh, 1994, Endocrinology.

Relative binding and biochemical effects of heterodimeric and homodimeric isoforms of platelet‐derived growth factor in osteoblast‐enriched cultures from fetal rat bone

E. Canalis, M. Centrella, T. McCarthy, 1991, Journal of cellular physiology.

Triiodothyronine induces collagenase-3 and gelatinase B expression in murine osteoblasts.

R. Pereira, E. Canalis, V. Jorgetti, 1999, American journal of physiology. Endocrinology and metabolism.

Transforming growth factor β1 inhibits collagenase 3 expression by transcriptional and post‐transcriptional mechanisms in osteoblast cultures

E. Canalis, S. Rydziel, S. Varghese, 1997 .

Overexpression of twisted gastrulation inhibits bone morphogenetic protein action and prevents osteoblast cell differentiation in vitro.

E. Canalis, E. Gazzerro, V. Deregowski, 2005, Endocrinology.

Cortisol Inhibits the Synthesis of Insulin-like Growth Factor-binding Protein-5 in Bone Cell Cultures by Transcriptional Mechanisms (*)

E. Canalis, A. Delany, B. Gabbitas, 1996, The Journal of Biological Chemistry.

Regulation of insulin-like growth factor-II production in bone cultures.

E. Canalis, M. Centrella, T. McCarthy, 1991, Endocrinology.

Effects of platelet‐derived growth factor on bone formation in vitro

E. Canalis, M. Centrella, T. McCarthy, 1989, Journal of cellular physiology.

Growth hormone, skeletal growth factors and osteoporosis.

E. Canalis, 1995, Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists.

AENDO Mar. 39/3

E. Canalis, S. Varghese, Kyung-Ae Yu, 1999 .

Skeletal bone morphogenetic proteins suppress the expression of collagenase-3 by rat osteoblasts.

E. Canalis, E. Gazzerro, S. Rydziel, 1999, Endocrinology.

Insulin‐like growth factor I inhibits the transcription of collagenase 3 in osteoblast cultures

E. Canalis, A. Delany, S. Rydziel, 1997, Journal of cellular biochemistry.

Retinoic acid regulates the expression of insulin‐like growth factors I and II in osteoblasts

E. Canalis, B. Gabbitas, Bari Gabbitas, 1997, Journal of cellular physiology.

Cyclooxygenase-2 Suppresses the Anabolic Response to PTH Infusion in Mice

E. Canalis, D. Adams, C. Pilbeam, 2015, PloS one.

Dynamic bone morphometry and studies on the effects of serum on ben meta lism in vitro in a case of pycnodysostosis

R. Baron, E. Canalis, L. Raisz, 1980 .

Insulin-like growth factors sustain insulin-like growth factor-binding protein-5 expression in osteoblasts.

E. Canalis, B. Gabbitas, 1998, The American journal of physiology.

Autocrine down-regulation of collagenase-3 in rat bone cell cultures by insulin-like growth factors.

E. Canalis, A. Delany, S. Rydziel, 1996, Endocrinology.

The epidemiology of partialandrogen deficiency in aging men (PADAM).

R. Pereira, E. Canalis, E. Gazzerro, 2005 .

Signals that determine the fate of osteoblastic cells.

R. Pereira, E. Canalis, E. Gazzerro, 2005, Journal of endocrinological investigation.

Parathyroid hormone-related protein modulates the effect of transforming growth factor-beta on deoxyribonucleic acid and collagen synthesis in fetal rat bone cells.

J. Orloff, A. F. Stewart, E. Canalis, 1989, Endocrinology.

Excessive mechanical loading promotes osteoarthritis through the gremlin-1–NF-κB pathway

Song Ho Chang, Sakae Tanaka, Di Chen, 2019, Nature Communications.

Notch and the regulation of osteoclast differentiation and function.

E. Canalis, Jungeun Yu, 2020, Bone.

Growth hormone, insulin-like growth factors, and the skeleton.

G. Mazziotti, E. Canalis, A. Giustina, 2008, Endocrine reviews.

Effect of insulinlike growth factor I on DNA and protein synthesis in cultured rat calvaria.

E. Canalis, E Canalis, 1980, The Journal of clinical investigation.

0163-769X/03/$20.00/0 Endocrine Reviews 24(2):218–235 Printed in U.S.A. Copyright © 2003 by The Endocrine Society doi: 10.1210/er.2002-0023 Bone Morphogenetic Proteins, Their Antagonists, and the Skeleton

A. Economides, E. Canalis, E. Gazzerro, 2022 .

Notch in skeletal physiology and disease

E. Canalis, 2018, Osteoporosis International.

Notch inhibits osteoblast differentiation and causes osteopenia.

D. Durant, L. Stadmeyer, E. Canalis, 2008, Endocrinology.

A soluble bone morphogenetic protein type IA receptor increases bone mass and bone strength

M. Bouxsein, N. Solban, A. Grinberg, 2012, Proceedings of the National Academy of Sciences.

Effect of partially purified bone morphogenetic protein on DNA synthesis and cell replication in calvarial and fibroblast cultures.

E. Canalis, M. Centrella, M. Urist, 1985, Clinical orthopaedics and related research.

The hormonal and local regulation of bone formation.

E. Canalis, E. Canalis, 1983, Endocrine reviews.

Effect of epidermal growth factor on bone formation in vitro.

E. Canalis, L. Raisz, 1979, Endocrinology.

The Skeleton of Lateral Meningocele Syndrome

E. Canalis, 2021, Frontiers in Genetics.

Notch Signaling in Skeletal Diseases

E. Canalis, 2020, Encyclopedia of Bone Biology.

Notch and its ligands

E. Canalis, S. Zanotti, 2020 .

Notch Signaling and the Skeleton.

E. Canalis, S. Zanotti, 2016, Endocrine reviews.

Notch and the Skeleton

E. Canalis, S. Zanotti, 2009, Molecular and Cellular Biology.

CHAPTER 29 – Metabolic Bone Disease

E. Canalis, L. Raisz, J. Lorenzo, 2011 .

The divalent strontium salt S12911 enhances bone cell replication and bone formation in vitro.

P. Marie, E. Canalis, P. Deloffre, 1996, Bone.

Secondary osteoporosis : pathophysiology and management

E. Canalis, F. Mirza, 2015 .

Serum Cortisoland 11-Deoxycortisolby LiquidChromatography: ClinicalStudiesand Comparisonwith Radioimmunoassay

E. Canalis, G. Reardon, Antoinette M. Caldarella, 2004 .

Scanning electron microscopy and gel electrophoresis of vascularized periosteal autografts.

S. Ariyan, E. Canalis, R. Canalis, 1989, Plastic and reconstructive surgery.

Insulin-like growth factor I mediates selective anabolic effects of parathyroid hormone in bone cultures.

E. Canalis, M. Centrella, T. McCarthy, 1989, The Journal of clinical investigation.

Nemo‐like kinase inhibits osteoblastogenesis by suppressing bone morphogenetic protein and WNT canonical signaling

E. Canalis, S. Zanotti, 2012, Journal of cellular biochemistry.

Effects of basic fibroblast growth factor on bone formation in vitro.

E. Canalis, M. Centrella, T. McCarthy, 1988, The Journal of clinical investigation.

Mechanisms of anabolic therapies for osteoporosis.

Andrea Giustina, J. Bilezikian, E. Canalis, 2007, The New England journal of medicine.

Excessive mechanical loading promotes osteoarthritis through the gremlin-1–NF-κB pathway

Song Ho Chang, Sakae Tanaka, Di Chen, 2019, Nature Communications.

Skeletal tissue and transforming growth factor β

E. Canalis, M. Centrella, T. McCarthy, 1988, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Parathyroid hormone modulates transforming growth factor beta activity and binding in osteoblast-enriched cell cultures from fetal rat parietal bone.

E. Canalis, M. Centrella, T. McCarthy, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Effects of transforming growth factors on bone cells.

E. Canalis, M. Centrella, T. McCarthy, 1989, Connective tissue research.

Beta 2-microglobulin enhances insulin-like growth factor I receptor levels and synthesis in bone cell cultures.

E. Canalis, M. Centrella, T. McCarthy, 1989, The Journal of biological chemistry.

Mechanisms of Glucocorticoid Action in Bone

E. Canalis, A. Delany, 2002, Current osteoporosis reports.

The Metastasis-Associated Metalloproteinase Stromelysin-3 Is Induced by Transforming Growth Factor-β in Osteoblasts and Fibroblasts.

E. Canalis, A. Delany, 2001, Endocrinology.

The metastasis-associated metalloproteinase stromelysin-3 is induced by transforming growth factor-beta in osteoblasts and fibroblasts.

E. Canalis, A. Delany, 2001, Endocrinology.

Hajdu Cheney Mouse Mutants Exhibit Osteopenia, Increased Osteoclastogenesis, and Bone Resorption*♦

E. Canalis, S. Zanotti, S. Yee, 2015, The Journal of Biological Chemistry.

Hajdu-Cheney syndrome: a review

E. Canalis, S. Zanotti, 2014, Orphanet Journal of Rare Diseases.

Notch Signaling in Osteoblasts

E. Canalis, Ernesto Canalis, 2008, Science Signaling.

Notch 1 impairs osteoblastic cell differentiation.

E. Canalis, E. Gazzerro, A. Delany, 2003, Endocrinology.

Cortisol regulates the expression of Notch in osteoblasts

D. Durant, E. Canalis, A. Delany, 2002, Journal of cellular biochemistry.

Connective Tissue Growth Factor Enhances Osteoblastogenesis in Vitro*

E. Canalis, S. Zanotti, A. Smerdel-Ramoya, 2008, Journal of Biological Chemistry.

Role of the Ram Domain and Ankyrin Repeats on Notch Signaling and Activity in Cells of Osteoblastic Lineage

E. Canalis, E. Gazzerro, S. Rydziel, 2006, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

The Hajdu Cheney Mutation Is a Determinant of B-Cell Allocation of the Splenic Marginal Zone.

A. Sanjay, E. Canalis, S. Zanotti, 2018, The American journal of pathology.

An Antibody to Notch2 Reverses the Osteopenic Phenotype of Hajdu-Cheney Mutant Male Mice

A. Sanjay, E. Canalis, S. Zanotti, 2017, Endocrinology.

RARE BONE DISEASE ( CB LANGMAN AND E SHORE , SECTION EDITORS ) Hajdu-Cheney Syndrome , a Disease Associated with NOTCH 2 Mutations

E. Canalis, S. Zanotti, 2016 .

Notch signaling in skeletal health and disease.

E. Canalis, Stefano Zanotti, Ernesto Canalis, 2013, European journal of endocrinology.

Col3.6-HSD2 transgenic mice: a glucocorticoid loss-of-function model spanning early and late osteoblast differentiation.

E. Canalis, B. Kream, Maobin Yang, 2010, Bone.

Mice harboring a Hajdu Cheney Syndrome mutation are sensitized to osteoarthritis.

E. Canalis, J. Wolf, S. Zanotti, 2018, Bone.

A novel spontaneous mutation of Irs1 in mice results in hyperinsulinemia, reduced growth, low bone mass and impaired adipogenesis.

L. Donahue, T. Clemens, K. Johnson, 2010, The Journal of endocrinology.

Growth factors and the regulation of bone remodeling.

E. Canalis, M. Centrella, T. McCarthy, 1988, The Journal of clinical investigation.

MANAGEMENT OF ENDOCRINE DISEASE: Novel anabolic treatments for osteoporosis.

E. Canalis, 2018, European journal of endocrinology.

Wnt signalling in osteoporosis: mechanisms and novel therapeutic approaches

E. Canalis, 2013, Nature Reviews Endocrinology.

Notch Regulation of Bone Development and Remodeling and Related Skeletal Disorders

E. Canalis, S. Zanotti, 2011, Calcified Tissue International.

The lateral meningocele syndrome mutation causes marked osteopenia in mice

E. Canalis, S. Zanotti, S. Yee, 2018, The Journal of Biological Chemistry.

Effect of growth factors on bone cell replication and differentiation.

E. Canalis, 1985, Clinical orthopaedics and related research.

Transcriptional repression of insulin-like growth factor I by glucocorticoids in rat bone cells.

E. Canalis, A. Delany, E. Canalis, 1995, Endocrinology.

Activation Of Nfatc2 in osteoblasts causes osteopenia

E. Canalis, S. Zanotti, 2015, Journal of cellular physiology.

Direct stimulation of bone resorption by thyroid hormones.

G. Mundy, E. Canalis, L. Raisz, 1976, The Journal of clinical investigation.

Bone morphogenetic proteins and their antagonists

E. Canalis, E. Gazzerro, 2007, Reviews in Endocrine and Metabolic Disorders.

Isolation of a nontransforming bone-derived growth factor from medium conditioned by fetal rat calvariae.

E. Canalis, M. Centrella, 1986, Endocrinology.

Effect of bone-derived growth factor on DNA, RNA, and proteoglycan synthesis in cultures of rabbit costal chondrocytes.

E. Canalis, L. Raisz, Y. Nomura, 1982, Metabolism: clinical and experimental.

M. Bouxsein, L. Stadmeyer, E. Canalis, 2007 .

Glucocorticoid suppression of IGF I transcription in osteoblasts.

D. Durant, E. Canalis, A. Delany, 2001, Molecular Endocrinology.

Transforming growth factor-beta and remodeling of bone.

E. Canalis, M. Centrella, T. McCarthy, 1991, The Journal of bone and joint surgery. American volume.

Differential effects of continuous and transient treatment with parathyroid hormone related peptide (PTHrp) on bone collagen synthesis.

E. Canalis, M. Centrella, T. McCarthy, 1990, Endocrinology.

Effects of glucocorticoids on the skeleton.

R. Pereira, E. Canalis, A. Delany, 2002, Journal of pediatric endocrinology & metabolism : JPEM.

Canonical Notch activation in osteocytes causes osteopetrosis.

E. Canalis, S. Zanotti, L. Schilling, 2016, American journal of physiology. Endocrinology and metabolism.

Effects of activated T cells on osteoclastogenesis depend on how they are activated.

E. Canalis, S. Wikel, F. Sylvester, 2004, Bone.

Invited review of a workshop: anabolic hormones in bone: basic research and therapeutic potential.

R. Margolis, E. Canalis, N. Partridge, 1996, The Journal of clinical endocrinology and metabolism.

BMD Regulation on Mouse Distal Chromosome 1, Candidate Genes, and Response to Ovariectomy or Dietary Fat

L. Donahue, L. Reinholdt, C. Ackert-Bicknell, 2010, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Stimulation of DNA and collagen synthesis by autologous growth factor in cultured fetal rat calvaria.

E. Canalis, L. Raisz, W. Peck, 1980, Science.

Overexpression of IGF-Binding Protein 5 Alters Mineral and Matrix Properties in Mouse Femora: An Infrared Imaging Study

A. Boskey, E. Canalis, E. Atti, 2005, Calcified Tissue International.

Factors That Regulate Bone Formation

E. Canalis, M. Centrella, T. McCarthy, 1993 .

Isolation of EGF‐dependent transforming growth factor (TGFβ‐like) activity from culture medium conditioned by fetal rat calvariae

E. Canalis, M. Centrella, Michael Centrella, 1987, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Skeletal growth factors.

E. Canalis, S. Varghese, J. Pash, 2000, Critical reviews in eukaryotic gene expression.

CHAPTER 19 – Skeletal Growth Factors

E. Canalis, 2008 .

Directing the expression of a green fluorescent protein transgene in differentiated osteoblasts: comparison between rat type I collagen and rat osteocalcin promoters.

D. Rowe, I. Kalajzic, E. Canalis, 2002, Bone.

Growth Factors and the Skeleton

E. Canalis, 1998 .

Sex and Genetic Factors Determine Osteoblastic Differentiation Potential of Murine Bone Marrow Stromal Cells

I. Kalajzic, E. Canalis, H. Aguila, 2014, PloS one.

Update in new anabolic therapies for osteoporosis.

E. Canalis, 2010, The Journal of clinical endocrinology and metabolism.

Growth factors and the skeletal system

E. Canalis, M. Centrella, T. McCarthy, 1989, Journal of endocrinological investigation.

Nephroblastoma Overexpressed (Nov) Is a Novel Bone Morphogenetic Protein Antagonist

E. Canalis, 2007, Annals of the New York Academy of Sciences.

Growth factors and bone

E. Canalis, A. Delany, 1997 .

Parathyroid hormone enhances the transcript and polypeptide levels of insulin-like growth factor I in osteoblast-enriched cultures from fetal rat bone.

E. Canalis, M. Centrella, T. McCarthy, 1989, Endocrinology.

Effects of Sex and Notch Signaling on the Osteocyte Cell Pool

E. Canalis, S. Zanotti, L. Schilling, 2017, Journal of cellular physiology.

Hairy and Enhancer of Split-related with YRPW Motif (HEY)2 Regulates Bone Remodeling in Mice*

E. Canalis, S. Zanotti, 2013, The Journal of Biological Chemistry.

Leukemia inhibitory factor and oncostatin M stimulate collagenase-3 expression in osteoblasts.

E. Canalis, K. Yu, S. Varghese, 1999, The American journal of physiology.

MANAGEMENT OF ENDOCRINE DISEASE Secondary osteoporosis: pathophysiology and management

E. Canalis, F. Mirza, 2015 .

Parathyroid hormone inhibits Notch signaling in osteoblasts and osteocytes.

E. Canalis, S. Zanotti, 2017, Bone.

Transforming growth factor-β increases interleukin-6 transcripts in osteoblasts

N. Franchimont, E. Canalis, S. Rydziel, 2000 .

Transforming growth factor-beta increases interleukin-6 transcripts in osteoblasts.

N. Franchimont, E. Canalis, S. Rydziel, 2000, Bone.

Interleukin 6 mediates selected effects of Notch in chondrocytes.

E. Canalis, S. Zanotti, E. Canalis, 2013, Osteoarthritis and cartilage.

MANAGEMENT OF ENDOCRINE DISEASE: Bone disorders associated with acromegaly: mechanisms and treatment.

G. Mazziotti, E. Canalis, A. Lania, 2019, European journal of endocrinology.

Growth factor control of bone mass

E. Canalis, 2009, Journal of cellular biochemistry.

Bone morphogenetic protein‐2 suppresses collagenase‐3 promoter activity in osteoblasts through a runt domain factor 2 binding site

E. Canalis, S. Rydziel, S. Varghese, 2005, Journal of cellular physiology.

New understanding and treatments for osteoporosis

D. Cocchi, G. Mazziotti, E. Canalis, 2012, Endocrine.

Activation of the ERK pathway in osteoblastic cells, role of gremlin and BMP‐2

L. Stadmeyer, E. Canalis, S. Zanotti, 2008, Journal of cellular biochemistry.

Effect of glucocorticoids on type I collagen synthesis, alkaline phosphatase activity, and deoxyribonucleic acid content in cultured rat calvariae.

E. Canalis, 1983, Endocrinology.

Bone morphogenetic protein‐4 regulates its own expression in cultured osteoblasts

R. Pereira, E. Canalis, S. Rydziel, 2000, Journal of cellular physiology.

Effect of cortisol on periosteal and nonperiosteal collagen and DNA synthesis in cultured rat calvariae

E. Canalis, 1984, Calcified Tissue International.

Basic fibroblast growth factor destabilizes osteonectin mRNA in osteoblasts.

E. Canalis, A. Delany, E. Canalis, 1998, American journal of physiology. Cell physiology.

Bone loss or lost bone: Rationale and recommendations for the diagnosis and treatment of early postmenopausal bone loss

S. Silverman, X. Guo, C. Turner, 2009, Current osteoporosis reports.

Platelet‐derived growth factor induces collagenase 3 transcription in osteoblasts through the activator protein 1 complex

D. Durant, E. Canalis, S. Rydziel, 2000, Journal of cellular physiology.

Role of platelet derived growth factor in bone cell function.

E. Canalis, M. Centrella, T. McCarthy, 1992, Growth regulation.

Alendronate Stimulates Collagenase 3 Expression in Osteoblasts by Posttranscriptional Mechanisms

E. Canalis, S. Varghese, 2000, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Transcriptional regulation of collagenase‐3 by interleukin‐1 alpha in osteoblasts

E. Canalis, S. Varghese, 2003, Journal of cellular biochemistry.

Analysis of hydroxyproline by high performance liquid chromatography and its application to collagen turnover studies in bone cultures

E. Canalis, S. Rydziel, 1989, Calcified Tissue International.

Induced pluripotent stem cell technology in bone biology.

E. Canalis, P. Robey, F. Kidwai, 2023, Bone.

Hairy and enhancer of split 1 is a primary effector of NOTCH2 signaling and induces osteoclast differentiation and function

E. Canalis, Jungeun Yu, L. Schilling, 2021, The Journal of biological chemistry.

Antisense oligonucleotides targeting Notch2 ameliorate the osteopenic phenotype in a mouse model of Hajdu-Cheney syndrome

E. Canalis, T. R. Grossman, M. Carrer, 2020, The Journal of Biological Chemistry.

The Hajdu Cheney mutation sensitizes mice to the osteolytic actions of tumor necrosis factor α

E. Canalis, Jungeun Yu, 2019, The Journal of Biological Chemistry.

Clinical and experimental aspects of notch receptor signaling: Hajdu-Cheney syndrome and related disorders.

E. Canalis, 2017, Metabolism: clinical and experimental.

Induction of a NOTCH3 Lehman syndrome mutation in osteocytes causes osteopenia in male C57BL/6J mice.

A. Economides, E. Canalis, L. Schilling, 2022, Bone.

Hajdu Cheney Syndrome; report of a novel NOTCH2 mutation and treatment with denosumab.

A. Scarpa, L. Idolazzi, E. Canalis, 2016, Bone.

Sustained Notch2 signaling in osteoblasts, but not in osteoclasts, is linked to osteopenia in a mouse model of Hajdu-Cheney syndrome

A. Sanjay, A. Economides, E. Canalis, 2017, The Journal of Biological Chemistry.

Induction of the Hajdu-Cheney Syndrome Mutation in CD19 B Cells in Mice Alters B-Cell Allocation but Not Skeletal Homeostasis.

A. Sanjay, A. Economides, E. Canalis, 2018, The American journal of pathology.

1 1 2 3 CANONICAL NOTCH ACTIVATION IN OSTEOCYTES CAUSES OSTEOPETROSIS 4 5 6 7 8

E. Canalis, S. Zanotti, L. Schilling, 2015 .

Activation of Notch3 in osteoblasts/osteocytes causes compartment-specific changes in bone remodeling

E. Canalis, S. Zanotti, Jungeun Yu, 2021, The Journal of biological chemistry.

An antibody to Notch3 reverses the skeletal phenotype of lateral meningocele syndrome in male mice

E. Canalis, C. Siebel, Jungeun Yu, 2020, Journal of cellular physiology.

Glucocorticoids inhibit notch target gene expression in osteoblasts

E. Canalis, S. Zanotti, Jungeun Yu, 2018, Journal of cellular biochemistry.

Hairy and Enhancer of Split‐Related With YRPW Motif‐Like (HeyL) Is Dispensable for Bone Remodeling in Mice

E. Canalis, S. Zanotti, 2017, Journal of cellular biochemistry.

The Dmp1‐SOST Transgene Interacts With and Downregulates the Dmp1‐Cre Transgene and the RosaNotch Allele

E. Canalis, S. Zanotti, 2016, Journal of cellular biochemistry.

Isolation of growth factors from adult bovine bone

E. Canalis, M. Centrella, T. McCarthy, 1988, Calcified Tissue International.

Local bone growth factors

E. Canalis, 1984, Calcified Tissue International.

Infrared Analysis of the Mineral and Matrix in Bones of Osteonectin‐Null Mice and Their Wildtype Controls

A. Boskey, M. Amling, E. Canalis, 2003, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Nuclear factor of activated T cells 2 is required for osteoclast differentiation and function in vitro but not in vivo

E. Canalis, S. Zanotti, Jungeun Yu, 2018, Journal of cellular biochemistry.

Selective stimulation of sulfated glycosaminoglycan synthesis by multiplication-stimulating activity, cartilage-derived factor and bone-derived growth factor. Comparison of their actions on cultured chondrocytes with those of fibroblast growth factor and Rhodamine fibrosarcoma-derived growth factor.

E. Canalis, L. Raisz, Y. Hiraki, 1982, Biochimica et biophysica acta.

Bone Morphogenetic Proteins Induce Gremlin, a Protein That Limits Their Activity in Osteoblasts* *This work was supported by NIAMSD Grant AR-21707.

A. Economides, R. Pereira, E. Canalis, 2000, Endocrinology.

Effect of cartilage-derived factor on DNA and protein synthesis in cultured rat calvariae

E. Canalis, Y. Hiraki, F. Suzuki, 2006, Calcified Tissue International.

Mechanisms of glucocorticoid induced osteoporosis

E. Canalis, E Canalis, 2003, Current opinion in rheumatology.

Effects of prostaglandin E2 on bone formation in cultured fetal rat calvariae: role of insulin-like growth factor-I.

E. Canalis, T. McCarthy, B. Kream, 1993, Endocrinology.

Effect of multiplication-stimulating activity on DNA and protein synthesis in cultured fetal rat calvaria

E. Canalis, L. Raisz, 1979, Calcified Tissue International.

Mitogenesis in fetal rat bone cells simultaneously exposed to type β transforming growth factor and other growth regulators

E. Canalis, M. Centrella, T. McCarthy, 1987, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Genetic Dissection of Mouse Distal Chromosome 1 Reveals Three Linked BMD QTLs With Sex‐Dependent Regulation of Bone Phenotypes

L. Donahue, C. Ackert-Bicknell, E. Canalis, 2007, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Regulation of insulin-like growth factor I transcription by prostaglandin E2 in osteoblast cells.

C. Roberts, D. Leroith, M. Adamo, 1995, Endocrinology.

Role of nuclear factor of activated T cells in chondrogenesis osteogenesis and osteochondroma formation

E. Canalis, L. Schilling, T. Eller, 2022, Journal of Endocrinological Investigation.

Basic fibroblast growth factor stimulates collagenase-3 promoter activity in osteoblasts through an activator protein-1-binding site.

E. Canalis, S. Rydziel, S. Varghese, 2000, Endocrinology.

Insulin-like growth factors and their role in osteoporosis

E. Canalis, Ernesto Canalis, Donato Agnusdei, 1996, Calcified Tissue International.

Effects of desamino-(1-3)-insulin-like growth factor I on bone cell function in rat calvarial cultures.

E. Canalis, M. Centrella, T. McCarthy, 1991, Endocrinology.

Notch Regulation of Bone Development and Remodeling and Related Skeletal Disorders

E. Canalis, S. Zanotti, 2012, Calcified Tissue International.