J. Zabner

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Laser fluorescence bronchoscopy for detection of fluorescent reporter genes in airway epithelia

E. Hoffman, G. McLennan, J. Reinhardt, 2002, Gene Therapy.

Enhanced Sialic Acid-Dependent Endocytosis Explains the Increased Efficiency of Infection of Airway Epithelia by a Novel Adeno-Associated Virus

D. Schaffer, J. Zabner, J. Bergen, 2011, Journal of Virology.

Cellular and Molecular Barriers to Gene Transfer by a Cationic Lipid (*)

Joseph Zabner, M. Welsh, T. Moninger, 1995, The Journal of Biological Chemistry.

TLR4 mutations are associated with endotoxin hyporesponsiveness in humans

D. Schwartz, Michael P. Jones, J. Kline, 2000, Nature Genetics.

A role for the PDZ-binding domain of the coxsackie B virus and adenovirus receptor (CAR) in cell adhesion and growth

J. Zabner, K. Excoffon, A. Hruska-Hageman, 2004, Journal of Cell Science.

Characterization of fusion genes and the significantly expressed fusion isoforms in breast cancer by hybrid sequencing

Tyson A. Clark, J. Korlach, W. Wong, 2015, Nucleic acids research.

The porcine lung as a potential model for cystic fibrosis.

J. T. Fisher, G. McLennan, D. Meyerholz, 2008, American journal of physiology. Lung cellular and molecular physiology.

Impaired mucus detachment disrupts mucociliary transport in a piglet model of cystic fibrosis

E. Hoffman, M. Welsh, T. Moninger, 2014, Science.

Whole exome sequencing identifies novel candidate genes that modify chronic obstructive pulmonary disease susceptibility

Jinchuan Xing, S. Leng, S. Belinsky, 2016, Human Genomics.

Dual therapeutic utility of proteasome modulating agents for pharmaco-gene therapy of the cystic fibrosis airway.

Huidong Shi, C. Caldwell, J. Engelhardt, 2004, Molecular therapy : the journal of the American Society of Gene Therapy.

Effect of vitamin D3 on the antimicrobial activity of human airway surface liquid: preliminary results of a randomised placebo-controlled double-blind trial

A. Comellas, J. Zabner, A. Gerke, 2017, BMJ Open Respiratory Research.

Effect of vitamin D3 on the antimicrobial activity of human airway surface liquid: preliminary results of a randomised placebo-controlled double-blind trial

A. Comellas, J. Zabner, A. Gerke, 2017, BMJ Open Respiratory Research.

Iron oxide nanoparticles induce Pseudomonas aeruginosa growth, induce biofilm formation, and inhibit antimicrobial peptide function.

Chia-Ming Wu, A. Comellas, J. Zabner, 2014, Environmental science. Nano.

Large-scale gene discovery in human airway epithelia reveals novel transcripts.

M. Soares, T. Casavant, T. Scheetz, 2004, Physiological genomics.

Foxj1 is required for apical localization of ezrin in airway epithelial cells

S. Brody, J. Zabner, E. Richer, 2003, Journal of Cell Science.

Vaccinia Virus Entry, Exit, and Interaction with Differentiated Human Airway Epithelia

M. Welsh, J. Zabner, J. Mchugh, 2007, Journal of Virology.

Reovirus preferentially infects the basolateral surface and is released from the apical surface of polarized human respiratory epithelial cells.

J. Zabner, K. Excoffon, T. Dermody, 2008, The Journal of infectious diseases.

Activity of abundant antimicrobials of the human airway.

E. Greenberg, M. Welsh, J. Zabner, 1999, American journal of respiratory cell and molecular biology.

Adeno-associated virus types 5 and 6 use distinct receptors for cell entry.

C. Halbert, A. Miller, J. Zabner, 2005, Human gene therapy.

A mouse model for the delta F508 allele of cystic fibrosis.

K. Thomas, M. Capecchi, J. Zabner, 1995, The Journal of clinical investigation.

Lack of high affinity fiber receptor activity explains the resistance of ciliated airway epithelia to adenovirus infection.

J. Zabner, M. Welsh, P. Freimuth, 1997, The Journal of clinical investigation.

Basolateral Localization of Fiber Receptors Limits Adenovirus Infection from the Apical Surface of Airway Epithelia*

M. Welsh, J. Bergelson, J. Zabner, 1999, The Journal of Biological Chemistry.

Seasonal Antimicrobial Activity of the Airway: Post-Hoc Analysis of a Randomized Placebo-Controlled Double-Blind Trial

P. Polgreen, A. Comellas, J. Zabner, 2020, Nutrients.

Effects of Tham Nasal Alkalinization on Airway Microbial Communities: A Pilot Study in Non-CF and CF Adults

D. Stoltz, J. Zabner, P. Singh, 2021, medRxiv.

Effects of Tham Nasal Alkalinization on Airway Microbial Communities: A Pilot Study in Non-CF and CF Adults.

D. Stoltz, J. Zabner, Pradeep K. Singh, 2021, The Annals of otology, rhinology, and laryngology.

Chest wall strapping increases expiratory airflow and detectable airway segments in computer tomographic scans of normal and obstructed lungs.

David W. Kaczka, M. Eberlein, R. Brower, 2018, Journal of applied physiology.

Adenovirus-mediated gene transfer to ciliated airway epithelia requires prolonged incubation time

E. Friedman, J. Zabner, M. Welsh, 1996, Journal of virology.

Repeat administration of an adenovirus vector encoding cystic fibrosis transmembrane conductance regulator to the nasal epithelium of patients with cystic fibrosis.

R. Gibson, B. Ramsey, J. Zabner, 1996, The Journal of clinical investigation.

Apical Localization of the Coxsackie-Adenovirus Receptor by Glycosyl-Phosphatidylinositol Modification Is Sufficient for Adenovirus-Mediated Gene Transfer through the Apical Surface of Human Airway Epithelia

M. Schroth, R. Crystal, M. Welsh, 2001, Journal of Virology.

V-type ATPase Mediates Airway Surface Liquid Acidification in Pig Small Airway Epithelial Cells.

Julio E. Noriega, D. Meyerholz, D. Stoltz, 2021, American journal of respiratory cell and molecular biology.

Ivacaftor-induced sweat chloride reductions correlate with increases in airway surface liquid pH in cystic fibrosis.

M. Welsh, D. Stoltz, J. Zabner, 2018, JCI insight.

Repurposing tromethamine as inhaled therapy to treat CF airway disease.

M. Welsh, D. Stoltz, J. Zabner, 2016, JCI insight.

Incorporation of adenovirus in calcium phosphate precipitates enhances gene transfer to airway epithelia in vitro and in vivo.

T. Moninger, J. Zabner, A. Fasbender, 1998, The Journal of clinical investigation.

Higher BMI is associated with higher expiratory airflow normalised for lung volume (FEF25–75/FVC) in COPD

V. Kim, E. Hoffman, J. Newell, 2017, BMJ Open Respiratory Research.

HSP90 inhibitor geldanamycin reverts IL-13– and IL-17–induced airway goblet cell metaplasia

J. Zabner, A. Pezzulo, L. G. V. Buonfiglio, 2019, The Journal of clinical investigation.

Engineering Novel Cell Surface Receptors for Virus-mediated Gene Transfer*

C. Bertozzi, J. Zabner, M. Welsh, 1999, The Journal of Biological Chemistry.

The Coxsackievirus and Adenovirus Receptor: A new adhesion protein in cochlear development

W. Kimberling, M. Hansen, H. Najmabadi, 2006, Hearing Research.

Adenoviral-mediated gene transfer to fetal pulmonary epithelia in vitro and in vivo.

G. Koretzky, J. Zabner, P. McCray, 1995, The Journal of clinical investigation.

Patterns and density of early tracheal colonization in intensive care unit patients.

A. Ashare, J. Zabner, G. Doern, 2009, Journal of critical care.

Glucose Depletion in the Airway Surface Liquid Is Essential for Sterility of the Airways

K. Rahmouni, D. Stoltz, J. Zabner, 2011, PloS one.

CaMKII Is Essential for the Proasthmatic Effects of Oxidation

Mark E. Anderson, P. Howarth, D. Meyerholz, 2013, Science Translational Medicine.

Pigs and humans with cystic fibrosis have reduced insulin-like growth factor 1 (IGF1) levels at birth

M. Welsh, R. Prather, M. Rogan, 2010, Proceedings of the National Academy of Sciences.

Effect of the E4 region on the persistence of transgene expression from adenovirus vectors

Alan E. Smith, J. Zabner, A. Smith, 1997, Journal of virology.

Canine Adenovirus Vectors for Lung-Directed Gene Transfer: Efficacy, Immune Response, and Duration of Transgene Expression Using Helper-Dependent Vectors

J. Zabner, E. Kremer, A. Keriel, 2006, Journal of Virology.

Efficient killing of inhaled bacteria in ΔF508 mice: role of airway surface liquid composition.

M. Welsh, J. Zabner, P. McCray, 1999, American journal of physiology. Lung cellular and molecular physiology.

Comparison of DNA-lipid complexes and DNA alone for gene transfer to cystic fibrosis airway epithelia in vivo.

J. Morris, J. Marshall, J. Zabner, 1997, The Journal of clinical investigation.

Safety assessment of nebulized xylitol in beagle dogs

M. Welsh, J. McDonald, S. Seilkop, 2012, Inhalation toxicology.

Airway surface liquid from smokers promotes bacterial growth and biofilm formation via iron-lactoferrin imbalance

Julio E. Noriega, A. Comellas, J. Zabner, 2018, Respiratory Research.

Lysozyme secretion by submucosal glands protects the airway from bacterial infection.

M. Welsh, J. Engelhardt, J. Zabner, 2005, American journal of respiratory cell and molecular biology.

Interleukin-9 induces goblet cell hyperplasia during repair of human airway epithelia.

T. Moninger, J. Zabner, P. Vermeer, 2003, American journal of respiratory cell and molecular biology.

Mitochondrial-targeted antioxidant therapy decreases transforming growth factor-β-mediated collagen production in a murine asthma model.

Mark E. Anderson, A. Ryan, S. Murthy, 2015, American journal of respiratory cell and molecular biology.

Histamine decreases E-cadherin-based adhesion to increase permeability of human airway epithelium.

J. Zabner, D. Shasby, S. Shasby, 2003, Chest.

Vitamin D-mediated effects on airway innate immunity in vitro

A. Comellas, J. Zabner, J. Klesney-Tait, 2022, PloS one.

The CCT promoter directs high-level transgene expression in distal lung epithelial cell lines.

A. Ryan, R. Mallampalli, Jiming Zhou, 2004, American journal of respiratory cell and molecular biology.

Safety assessment of inhaled xylitol in mice and healthy volunteers

J. Kline, J. Zabner, P. Thorne, 2004, Respiratory research.

MMP9 modulates tight junction integrity and cell viability in human airway epithelia.

S. Keshavjee, T. Moninger, J. Kline, 2009, American journal of physiology. Lung cellular and molecular physiology.

In Situ Quantification of Glucose Concentration in Airway Surface Liquid With Functionalized ZnO Nanorod-Coated Microelectrodes.

M. Willander, M. Asif, J. Zabner, 2011, Journal of analytical & bioanalytical techniques.

Adenovirus-mediated gene transfer for cystic fibrosis: Part A. Safety of dose and repeat administration in the nasal epithelium. Part B. Clinical efficacy in the maxillary sinus.

M. Welsh, J. Zabner, A. Smith, 1995, Human gene therapy.

The effects of graded administration of positive end expiratory pressure on the fluid filtration rate in isolated rabbit lungs, using normal lungs, hydrostatic oedema lungs and oleic acid induced oedema

J. Zabner, L. S. Angeli, R. Sánchez de León, 2007, Intensive Care Medicine.

R. Martinez, J. Zabner, L. S. Angeli, 2005, Intensive Care Medicine.

Cystic fibrosis carriers are at increased risk for a wide range of cystic fibrosis-related conditions

Aaron C. Miller, J. Cavanaugh, P. Polgreen, 2019, Proceedings of the National Academy of Sciences of the United States of America.

Transepithelial migration of neutrophils into the lung requires TREM-1.

D. Meyerholz, M. Colonna, T. Moninger, 2013, The Journal of clinical investigation.

Interdependency of &bgr;-Adrenergic Receptors and CFTR in Regulation of Alveolar Active Na+ Transport

P. Factor, J. Sznajder, G. Mutlu, 2005, Circulation research.

A novel host defense system of airways is defective in cystic fibrosis.

J. Zabner, K. Excoffon, P. McCray, 2007, American journal of respiratory and critical care medicine.

Upregulation of pirin expression by chronic cigarette smoking is associated with bronchial epithelial cell apoptosis

A. Heguy, R. Crystal, T. O'Connor, 2007, Respiratory research.

An in vitro model of differentiated human airway epithelia. Methods for establishing primary cultures.

M. Welsh, T. Moninger, J. Zabner, 2002, Methods in molecular biology.

Neonates with cystic fibrosis have a reduced nasal liquid pH; a small pilot study.

M. Welsh, D. Stoltz, J. Zabner, 2014, Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society.

Normal sweat chloride values do not exclude the diagnosis of cystic fibrosis.

M. Welsh, J. Zabner, P. McCray, 1995, American journal of respiratory and critical care medicine.

Concentration of the antibacterial precursor thiocyanate in cystic fibrosis airway secretions.

M. Welsh, D. Stoltz, J. Zabner, 2011, Free radical biology & medicine.

The air-liquid interface and use of primary cell cultures are important to recapitulate the transcriptional profile of in vivo airway epithelia.

T. Scheetz, R. Crystal, B. Harvey, 2011, American journal of physiology. Lung cellular and molecular physiology.

Inflammatory response in airway epithelial cells isolated from patients with cystic fibrosis.

D. Look, J. Zabner, T. Ferkol, 2002, American journal of respiratory and critical care medicine.

Delivery of an adenovirus vector in a calcium phosphate coprecipitate enhances the therapeutic index of gene transfer to airway epithelia.

J. Zabner, M. Welsh, J. H. Lee, 1999, Human gene therapy.

Bronchoscopic assessment of airway retention time of aerosolized xylitol

J. Zabner, J. L. Watt, M. Allaman, 2006, Respiratory research.

Cells in Models of Sepsis and Asthma Bronchial Epithelial and Smooth Muscle Anaphylatoxin C3a and C5a Receptors on Expression of the Complement

J. Zabner, P. McCray, R. Wetsel, 2001 .

Randomized controlled study of aerosolized hypertonic xylitol versus hypertonic saline in hospitalized patients with pulmonary exacerbation of cystic fibrosis.

J. Cavanaugh, D. Hornick, J. Zabner, 2020, Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society.

Development of cystic fibrosis and noncystic fibrosis airway cell lines.

M. Welsh, J. Zabner, A. Klingelhutz, 2003, American journal of physiology. Lung cellular and molecular physiology.

Tromethamine improves mucociliary clearance in cystic fibrosis pigs

D. Stoltz, J. Zabner, N. Gansemer, 2022, Physiological reports.

Bronchoalveolar Fluid Is Not a Major Hindrance to Virus-Mediated Gene Therapy in Cystic Fibrosis

D. Flaherty, G. Denning, C. Rooney, 2002, Journal of Virology.

Starting a lung transplant program: a roadmap for long-term excellence.

M. Iannettoni, P. Gruber, M. Eberlein, 2015, Chest.

Complexes of Adenovirus with Polycationic Polymers and Cationic Lipids Increase the Efficiency of Gene Transfer in Vitro and in Vivo*

B. Davidson, T. Moninger, J. Zabner, 1997, The Journal of Biological Chemistry.

The osmolyte xylitol reduces the salt concentration of airway surface liquid and may enhance bacterial killing.

M. Welsh, D. Look, J. Zabner, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Increasing epithelial junction permeability enhances gene transfer to airway epithelia In vivo.

B. Davidson, J. Zabner, P. McCray, 2000, American journal of respiratory cell and molecular biology.

Disruption of the CFTR Gene Produces a Model of Cystic Fibrosis in Newborn Pigs

David K. Meyerholz, Christopher S. Rogers, Joseph Zabner, 2008, Science.

Development of a polarized pancreatic ductular cell epithelium for physiological studies.

J. Engelhardt, J. Zabner, A. Uc, 2018, Journal of applied physiology.

Cystic Fibrosis Transmembrane Conductance Regulator Potentiation as a Therapeutic Strategy for Pulmonary Edema: A Proof-of-Concept Study in Pigs

A. Comellas, D. Stoltz, J. Zabner, 2017, Critical care medicine.

Postnatal airway growth in cystic fibrosis piglets.

E. Hoffman, D. Meyerholz, M. Welsh, 2017, Journal of applied physiology.

Intestinal CFTR expression alleviates meconium ileus in cystic fibrosis pigs.

E. Hoffman, D. Meyerholz, M. Welsh, 2013, The Journal of clinical investigation.

Title Intestinal CFTR expression alleviates meconium ileus in cysticfibrosis pigs

E. Hoffman, D. Meyerholz, M. Welsh, 2013 .

CFTR is required for maximal transepithelial liquid transport in pig alveolar epithelia.

M. Welsh, A. Comellas, T. Moninger, 2012, American journal of physiology. Lung cellular and molecular physiology.

Sinus Hypoplasia Precedes Sinus Infection in a Porcine Model of Cystic Fibrosis

D. Meyerholz, M. Welsh, T. Moninger, 2012, The Laryngoscope.

Requirements for ion and solute transport, and pH regulation during enamel maturation

S. K. Baniwal, M. Welsh, A. Nanci, 2012, Journal of cellular physiology.

Enamel Pathology Resulting from Loss of Function in the Cystic Fibrosis Transmembrane Conductance Regulator in a Porcine Animal Model

M. Welsh, M. Paine, J. Zabner, 2011, Cells Tissues Organs.

Functional activation of the cystic fibrosis trafficking mutant delta F508-CFTR by overexpression.

M. Welsh, J. Marshall, S. Fang, 1995, The American journal of physiology.

Coal Fly Ash Impairs Airway Antimicrobial Peptides and Increases Bacterial Growth

A. Comellas, J. Zabner, J. Baltrusaitis, 2013, PloS one.

Targeting the urokinase plasminogen activator receptor enhances gene transfer to human airway epithelia.

S. Yi, J. Zabner, M. Welsh, 2000, The Journal of clinical investigation.

Binding of Adeno-associated Virus Type 5 to 2,3-Linked Sialic Acid Is Required for Gene Transfer*

M. Welsh, J. Chiorini, S. Keshavjee, 2001, The Journal of Biological Chemistry.

Calcium phosphate precipitates augment adenovirus-mediated gene transfer to blood vessels in vitro and in vivo

D. Heistad, F. Faraci, J. Zabner, 2000, Gene Therapy.

Differentiation of human airway epithelia is dependent on erbB2.

J. Zabner, John H. Lee, Philip H. Karp, 2006, American journal of physiology. Lung cellular and molecular physiology.

Adenovirus-mediated generation of cAMP-stimulated Cl- transport in cystic fibrosis airway epithelia in vitro: effect of promoter and administration method.

J. Zabner, M. Welsh, A. Smith, 1996, Gene therapy.

Protein Kinase Cζ Inhibitor Promotes Resolution of Bleomycin-Induced Acute Lung Injury.

A. Comellas, J. Zabner, J. Sieren, 2016, American journal of respiratory cell and molecular biology.

Thixotropic solutions enhance viral-mediated gene transfer to airway epithelia.

S. Keshavjee, T. Moninger, J. Zabner, 2002, American journal of respiratory cell and molecular biology.

Isoform-Specific Regulation and Localization of the Coxsackie and Adenovirus Receptor in Human Airway Epithelia

J. Zabner, K. Excoffon, K. Parekh, 2010, PloS one.

Keratinocyte growth factor induced epithelial proliferation facilitates retroviral–mediated gene transfer to distal lung epithelia in vivo

B. Davidson, J. Zabner, V. Slepushkin, 1999, The journal of gene medicine.

Keratinocyte growth factor induced epithelial proliferation facilitates retroviral–mediated gene transfer to distal lung epithelia in vivo

B. Davidson, J. Zabner, V. Slepushkin, 1999, The journal of gene medicine.

Alveolar macrophages inhibit retrovirus-mediated gene transfer to airway epithelia.

B. Davidson, S. Chada, J. Kline, 1997, Human gene therapy.

DNA transfection of macaque and murine respiratory tissue is greatly enhanced by use of a nuclease inhibitor

R. Malone, T. Watts, J. Zabner, 2002, The journal of gene medicine.

E4ORF3 Requirement for Achieving Long-Term Transgene Expression from the Cytomegalovirus Promoter in Adenovirus Vectors

J. Zabner, J. S. St. George, M. Perricone, 1999, Journal of Virology.

Segregation of receptor and ligand regulates activation of epithelial growth factor receptor

M. Welsh, T. Moninger, J. Zabner, 2003, Nature.

erbB1 Functions as a Sensor of Airway Epithelial Integrity by Regulation of Protein Phosphatase 2A Activity*

M. Welsh, J. Zabner, P. Vermeer, 2006, Journal of Biological Chemistry.

Lectin binding and endocytosis at the apical surface of human airway epithelia

J. Zabner, M. Welsh, Smp Yi, 2001, Gene Therapy.

Augmentation of lung liquid clearance via adenovirus-mediated transfer of a Na,K-ATPase beta1 subunit gene.

P. Factor, J. Sznajder, K. Ridge, 1998, The Journal of clinical investigation.

A Common Mutation in Paraoxonase-2 Results in Impaired Lactonase Activity*

Xia Yang, D. Shih, A. Lusis, 2009, The Journal of Biological Chemistry.

Adenovirus Calcium Phosphate Coprecipitates Enhance Squamous Cell Carcinoma Gene Transfer

M. Welsh, J. Zabner, S. Graham, 2001, The Laryngoscope.

The role of the extracellular domain in the biology of the coxsackievirus and adenovirus receptor.

J. Zabner, K. Excoffon, Geri L. Traver, 2005, American journal of respiratory cell and molecular biology.

Modification of an adenoviral vector with biologically selected peptides: a novel strategy for gene delivery to cells of choice.

H. Romanczuk, J. Zabner, S. Wadsworth, 1999, Human gene therapy.

Giants in Chest Medicine: Donald C. Zavala, MD, FCCP.

J. Kline, J. Zabner, 2019, Chest.

Poster Session Abstracts

E. A. Hoffman, D. Stoltz, J. Zabner, 1997, Pediatric pulmonology.

Expression of the Complement Anaphylatoxin C3a and C5a Receptors on Bronchial Epithelial and Smooth Muscle Cells in Models of Sepsis and Asthma1

J. Zabner, P. McCray, R. Wetsel, 2001, The Journal of Immunology.

Effect of high frequency oscillatory ventilation on fluid filtration rate in isolated perfused rabbit lungs

J. Zabner, R. Martinez-Ruiz, R. Sánchez de León, 2004, Intensive Care Medicine.

Safety assessment of inhaled xylitol in subjects with cystic fibrosis.

J. Kline, J. Zabner, J. L. Watt, 2007, Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society.

A Chimeric Type 2 Adenovirus Vector with a Type 17 Fiber Enhances Gene Transfer to Human Airway Epithelia

B. Davidson, J. Zabner, M. Chillon, 1999, Journal of Virology.

Hoechst increases adeno‐associated virus‐mediated transgene expression in airway epithelia by inducing the cytomegalovirus promoter

J. Zabner, David D. Dickey, K. Excoffon, 2012, The journal of gene medicine.

Group D Adenoviruses Infect Primary Central Nervous System Cells More Efficiently than Those from Group C

B. Davidson, M. Welsh, J. Zabner, 1999, Journal of Virology.

Xylitol Enhances Bacterial Killing in the Rabbit Maxillary Sinus

J. Zabner, S. Graham, E. Ozer, 2004, The Laryngoscope.

Inactivation of a Pseudomonas aeruginosa quorum-sensing signal by human airway epithelia.

E. Greenberg, M. Welsh, J. Zabner, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Adenovirus Fiber Disrupts CAR-Mediated Intercellular Adhesion Allowing Virus Escape

M. Welsh, T. Moninger, J. Zabner, 2002, Cell.

Medical reversal of chronic sinusitis in a cystic fibrosis patient with ivacaftor

D. Stoltz, D. Hornick, J. Zabner, 2015, International forum of allergy & rhinology.

Protein composition of bronchoalveolar lavage fluid and airway surface liquid from newborn pigs.

S. Fisher, K. Williams, C. Wohlford-Lenane, 2013, American journal of physiology. Lung cellular and molecular physiology.

pH modulates the activity and synergism of the airway surface liquid antimicrobials β-defensin-3 and LL-37

M. Welsh, D. Stoltz, J. Zabner, 2014, Proceedings of the National Academy of Sciences.

FXYD3 facilitates Na+ and liquid absorption across human airway epithelia by increasing the transport capacity of the Na/K ATPase

J. Zabner, A. Thurman, A. Pezzulo, 2022, American journal of physiology. Cell physiology.

Cystic fibrosis gene therapy using an adenovirus vector: in vivo safety and efficacy in nasal epithelium.

M. Welsh, J. Zabner, A. Smith, 1994, Human gene therapy.

Adenovirus-Mediated Gene Therapy for Head and Neck Squamous Cell Carcinomas

B. Davidson, J. Zabner, J. Kern, 1996, The Annals of otology, rhinology, and laryngology.

Expression of Human Paraoxonase 1 Decreases Superoxide Levels and Alters Bacterial Colonization in the Gut of Drosophila melanogaster

Emma E. Hornick, J. Manak, D. Stoltz, 2012, PloS one.

Paraoxonase 1, quorum sensing, and P. aeruginosa infection: a novel model.

D. Stoltz, J. Zabner, M. Estin, 2010, Advances in experimental medicine and biology.

Drosophila are protected from Pseudomonas aeruginosa lethality by transgenic expression of paraoxonase-1.

T. Moninger, M. Parsek, D. Stoltz, 2008, The Journal of clinical investigation.

Reduced Airway Surface pH Impairs Bacterial Killing in the Porcine Cystic Fibrosis Lung

M. Welsh, T. Moninger, C. Wohlford-Lenane, 2012, Nature.

Loss of carbonic anhydrase XII function in individuals with elevated sweat chloride concentration and pulmonary airway disease.

W. Sly, Sarah M Robbins, G. Cutting, 2016, Human molecular genetics.

The Role of PON2 and PON3 in Atherosclerosis and Related Traits

D. Shih, D. Stoltz, J. Zabner, 2008 .

Recombinant adeno-associated virus type 2, 4, and 5 vectors: transduction of variant cell types and regions in the mammalian central nervous system.

I. Martins, R. Kotin, B. Davidson, 2000, Proceedings of the National Academy of Sciences of the United States of America.

A shortened adeno-associated virus expression cassette for CFTR gene transfer to cystic fibrosis airway epithelia.

M. Welsh, M. Stinski, J. Zabner, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Precision Genomic Medicine in Cystic Fibrosis

J. Zabner, Eugene H. Chang, 2015, Clinical and translational science.

Do cell junction protein mutations cause an airway phenotype in mice or humans?

J. Zabner, A. Pezzulo, Eugene H. Chang, 2011, American journal of respiratory cell and molecular biology.

Topography-dependent gene expression and function of common cell archetypes in large and small porcine airways

D. Meyerholz, M. Welsh, D. Stoltz, 2021, bioRxiv.

Electrolyte transport properties in distal small airways from cystic fibrosis pigs with implications for host defense.

D. Meyerholz, M. Welsh, A. Comellas, 2016, American journal of physiology. Lung cellular and molecular physiology.

Urban Particulate Matter Impairment of Airway Surface Liquid–Mediated Coronavirus Inactivation

J. L. Welch, M. Nonnenmann, A. Comellas, 2021, The Journal of infectious diseases.

airway-surface-liquid-mediated coronavirus inactivation

M. Nonnenmann, A. Comellas, J. Zabner, 2021 .

Novel AAV-mediated gene delivery system corrects CFTR function in pigs.

B. Singh, P. Sinn, D. Stoltz, 2019, American journal of respiratory cell and molecular biology.

in vivo airway epithelia of are important to recapitulate the transcriptional profile The air-liquid interface and use of primary cell cultures

T. Scheetz, R. Crystal, B. Harvey, 2013 .

Loss of CFTR chloride channels alters salt absorption by cystic fibrosis airway epithelia in vitro.

M. Welsh, J. Widdicombe, J. Zabner, 1998, Molecular cell.

Indoor Particulate Matter From Smoker Homes Induces Bacterial Growth, Biofilm Formation, and Impairs Airway Antimicrobial Activity. A Pilot Study

Julio E. Noriega, P. Polgreen, O. Chipara, 2020, Frontiers in Public Health.

Airway acidification initiates host defense abnormalities in cystic fibrosis mice

David K. Meyerholz, Joseph Zabner, David A. Stoltz, 2016, Science.

Adeno-Associated Virus Type 5 (AAV5) but Not AAV2 Binds to the Apical Surfaces of Airway Epithelia and Facilitates Gene Transfer

R. Kotin, B. Davidson, J. Chiorini, 2000, Journal of Virology.

Feline immunodeficiency virus vectors persistently transduce nondividing airway epithelia and correct the cystic fibrosis defect.

B. Davidson, T. Dubensky, S. Keshavjee, 1999, The Journal of clinical investigation.

Aggregates of mutant CFTR fragments in airway epithelial cells of CF lungs: new pathologic observations.

C. Ackerley, K. Du, H. Yeger, 2015, Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society.

Integrin α6β4 Identifies Human Distal Lung Epithelial Progenitor Cells with Potential as a Cell-Based Therapy for Cystic Fibrosis Lung Disease

P. Sinn, T. Moninger, D. Levasseur, 2013, PloS one.

Single-molecule long-read sequencing reveals the chromatin basis of gene expression

K. Au, L. Powers, J. Zabner, 2019, bioRxiv.

A low rate of cell proliferation and reduced DNA uptake limit cationic lipid-mediated gene transfer to primary cultures of ciliated human airway epithelia

J. Zabner, A. Fasbender, M. Welsh, 1997, Gene Therapy.

Optimization of cationic lipid-mediated gene transfer to airway epithelia.

J. Zabner, A. Fasbender, M. Welsh, 1995, The American journal of physiology.

A Mouse Model for the AF 508 Allele of Cystic Fibrosis

M. Capecchi, M. Welsh, J. Zabner, 2013 .

Gene transfer to airway epithelia using feline immunodeficiency virus-based lentivirus vectors.

P. Sinn, J. Zabner, P. McCray, 2002, Methods in enzymology.

CFTR with a partially deleted R domain corrects the cystic fibrosis chloride transport defect in human airway epithelia in vitro and in mouse nasal mucosa in vivo

M. Welsh, J. Zabner, A. Stecenko, 2002, Proceedings of the National Academy of Sciences of the United States of America.

HSP90 inhibition modulates NFκB signaling in airway goblet cell metaplasia

J. Zabner, A. Thurman, A. Pezzulo, 2020, bioRxiv.

Nominal carbonic anhydrase activity minimizes airway‐surface liquid pH changes during breathing

M. Welsh, J. Zabner, X. Tang, 2018, Physiological reports.

The ΔF508 Mutation Causes CFTR Misprocessing and Cystic Fibrosis–Like Disease in Pigs

S. Richter, D. Meyerholz, M. Welsh, 2011, Science Translational Medicine.

Adenovirus-mediated gene transfer transiently corrects the chloride transport defect in nasal epithelia of patients with cystic fibrosis

Joseph Zabner, Larry A. Couture, Scott M. Graham, 1993, Cell.

Fatal HBoV-1 infection in adult female cystic fibrosis patient

J. Zabner, C. Karagiannidis, O. Schildgen, 2016, Human Pathology: Case Reports.

Effect of Topical Nasal Pharmaceuticals on Sodium and Chloride Transport by Human Airway Epithelia

J. Zabner, Philip H. Karp, S. Graham, 2000, American journal of rhinology.

Absence of amiloride-sensitive sodium absorption in the airway of an infant with pseudohypoaldosteronism.

R. Lifton, J. Zabner, M. Welsh, 1999, The Journal of pediatrics.

Human cystic fibrosis airway epithelia have reduced Cl− conductance but not increased Na+ conductance

M. Welsh, S. Keshavjee, J. Zabner, 2011, Proceedings of the National Academy of Sciences.

Loss of Anion Transport without Increased Sodium Absorption Characterizes Newborn Porcine Cystic Fibrosis Airway Epithelia

M. Welsh, T. Moninger, D. Stoltz, 2010, Cell.

Cystic Fibrosis Pigs Develop Lung Disease and Exhibit Defective Bacterial Eradication at Birth

S. Richter, D. Meyerholz, M. Welsh, 2010, Science Translational Medicine.

Safety and efficacy of repetitive adenovirus–mediated transfer of CFTR cDNA to airway epithelia of primates and cotton rats

M. Welsh, Alan E. Smith, J. Zabner, 1994, Nature Genetics.

Indoor Air Pollution and Susceptibility to Tuberculosis Infection in Urban Vietnamese Children.

M. Segal, J. Balmes, P. Nahid, 2021, American Journal of Respiratory and Critical Care Medicine.

Residential urban tree canopy is associated with decreased mortality during tuberculosis treatment in California.

P. Barry, J. Balmes, P. Nahid, 2020, The Science of the total environment.

Paraoxonases, Quorum Sensing, And Pseudomonas Aeruginosa

D. Stoltz, J. Zabner, E. Ozer, 2008 .

Human and murine paraoxonase 1 are host modulators of Pseudomonas aeruginosa quorum-sensing.

E. Greenberg, D. Shih, A. Lusis, 2005, FEMS microbiology letters.

Role of f-box factor foxj1 in differentiation of ciliated airway epithelial cells.

S. Brody, J. Zabner, E. Richer, 2004, American journal of physiology. Lung cellular and molecular physiology.

Newborn Cystic Fibrosis Pigs Have a Blunted Early Response to an Inflammatory Stimulus.

D. Meyerholz, M. Welsh, C. Wohlford-Lenane, 2016, American journal of respiratory and critical care medicine.

The indirect effect of Tityus discrepans on rabbit pulmonary vasculature

J. Zabner, C. Sevcik, A. Crespo, 2003, Respiratory Physiology & Neurobiology.

Sequential magnetic resonance imaging analysis of the maxillary sinuses: implications for a model of gene therapy in cystic fibrosis

J. Zabner, M. Welsh, S. Graham, 1999, The Journal of Laryngology & Otology.

Adeno-Associated Virus Serotype 4 (AAV4) and AAV5 Both Require Sialic Acid Binding for Hemagglutination and Efficient Transduction but Differ in Sialic Acid Linkage Specificity

J. Chiorini, J. Zabner, K. Brown, 2001, Journal of Virology.

Stem Cells in Lung Biology Role of f-box factor foxj 1 in differentiation of ciliated airway epithelial cells

S. Brody, J. Zabner, E. Richer, 2004 .

Adenovirus-mediated erythropoietin production by airway epithelia is enhanced by apical localization of the coxsackie-adenovirus receptor in vivo.

D. Stoltz, J. Zabner, K. Excoffon, 2004, Molecular therapy : the journal of the American Society of Gene Therapy.

A Single-Cell Atlas of Large and Small Airways at Birth in a Porcine Model of Cystic Fibrosis.

D. Meyerholz, D. Stoltz, J. Zabner, 2022, American Journal of Respiratory Cell and Molecular Biology.

Differential expression of sheep beta-defensin-1 and -2 and interleukin 8 during acute Mannheimia haemolytica pneumonia.

David K Meyerholz, Joseph Zabner, Jack M Gallup, 2004, Microbial pathogenesis.

Adenoviral gene transfer corrects the ion transport defect in the sinus epithelia of a porcine CF model.

T. Moninger, D. Stoltz, J. Zabner, 2013, Molecular therapy : the journal of the American Society of Gene Therapy.

The Coxsackie B Virus and Adenovirus Receptor Resides in a Distinct Membrane Microdomain

T. Moninger, J. Zabner, K. J. A. Ashbourne Excoffon, 2003, Journal of Virology.

Adenovirus 5-fiber 35 chimeric vector mediates efficient apical correction of the cystic fibrosis transmembrane conductance regulator defect in cystic fibrosis primary airway epithelia.

N. Habib, M. Magnusson, J. Zabner, 2010, Human gene therapy.

Cellular localization and activity of Ad-delivered GFP-CFTR in airway epithelial and tracheal cells.

M. Lusky, J. Zabner, P. Boulanger, 2007, American journal of respiratory cell and molecular biology.

Abundant DNase I-Sensitive Bacterial DNA in Healthy Porcine Lungs and Its Implications for the Lung Microbiome

D. Stoltz, J. Zabner, B. Nassar, 2013, Applied and Environmental Microbiology.

Quantitative Chest CT Assessment of Small Airways Disease in Post-Acute SARS-CoV-2 Infection

E. Hoffman, Junfeng Guo, Josalyn L Cho, 2022, Radiology.

Small Airways Disease is a Post-Acute Sequelae of SARS-CoV-2 Infection

E. Hoffman, A. Pezzulo, A. Comellas, 2021, medRxiv.

Evaluation of in vivo total and regional air content and distribution in primate lungs with high-resolution CT.

E. Hoffman, B. Mullan, J. Galvin, 1997, Academic radiology.

Loss of cystic fibrosis transmembrane conductance regulator function produces abnormalities in tracheal development in neonatal pigs and young children.

G. McLennan, A. R. Smith, D. Meyerholz, 2010, American journal of respiratory and critical care medicine.

Paraoxonase-2 deficiency enhances Pseudomonas aeruginosa quorum sensing in murine tracheal epithelia.

D. Shih, A. Lusis, S. Reddy, 2007, American journal of physiology. Lung cellular and molecular physiology.

Effects of Coal Fly Ash Particulate Matter on the Antimicrobial Activity of Airway Surface Liquid

A. Comellas, J. Zabner, V. Grassian, 2017, Environmental health perspectives.

Efficient killing of inhaled bacteria in DeltaF508 mice: role of airway surface liquid composition.

M. Welsh, J. Zabner, P. McCray, 1999, The American journal of physiology.

Interdependency of (cid:1) -Adrenergic Receptors and CFTR in Regulation of Alveolar Active Na (cid:2) Transport

P. Factor, J. Sznajder, G. Mutlu, 2005 .

Continuous in-home PM2.5 concentrations of smokers with and without a history of respiratory exacerbations in Iowa, during and after an air purifier intervention

P. Polgreen, O. Chipara, A. Comellas, 2020, Journal of Exposure Science & Environmental Epidemiology.

Histamine alters E-cadherin cell adhesion to increase human airway epithelial permeability.

Joseph Zabner, David Stoltz, D. Stoltz, 2003, Journal of applied physiology.

Functional Effects of Coxsackievirus and Adenovirus Receptor Glycosylation on Homophilic Adhesion and Adenoviral Infection

J. Zabner, K. Excoffon, Geri L. Traver, 2007, Journal of Virology.

Directed evolution of adeno-associated virus to an infectious respiratory virus

D. Schaffer, S. Keshavjee, J. Zabner, 2009, Proceedings of the National Academy of Sciences.

CFTR DeltaF508 mutation has minimal effect on the gene expression profile of differentiated human airway epithelia.

Hakeem G. Almabrazi, T. Casavant, T. Scheetz, 2005, American journal of physiology. Lung cellular and molecular physiology.

The Effects of Timed Light Exposure in Critically Ill Patients: A Randomized Controlled Pilot Clinical Trial

E. van Cauter, Jesse B. Hall, A. Pohlman, 2018, American journal of respiratory and critical care medicine.

Role of PON in Anoxia-Reoxygenation Injury: A Drosophila Melanogaster Transgenic Model

Emma E. Hornick, A. Comellas, D. Stoltz, 2014, PloS one.

Practical reconstruction method for bioluminescence tomography.

Geoffrey McLennan, Ming Jiang, Ge Wang, 2005, Optics express.

Structure of Adeno-Associated Virus Serotype 5

T. Baker, J. Chiorini, N. Olson, 2004, Journal of Virology.

Bronchoscopic imaging of pulmonary mucosal vasculature responses to inflammatory mediators.

Geoffrey McLennan, Joseph Reinhardt, Melissa Suter, 2005, Journal of biomedical optics.

Polarized AAVR expression determines infectivity by AAV gene therapy vectors

J. Zabner, A. Pezzulo, M. A. Abou Alaiwa, 2019, Gene Therapy.

CFTR gene transfer with AAV improves early cystic fibrosis pig phenotypes.

D. Schaffer, M. Welsh, L. Powers, 2016, JCI insight.

Gene transfer of CFTR to airway epithelia: low levels of expression are sufficient to correct Cl- transport and overexpression can generate basolateral CFTR.

A. Beaudet, M. Welsh, J. Zabner, 2005, American journal of physiology. Lung cellular and molecular physiology.

Secreted and Transmembrane Mucins Inhibit Gene Transfer with AAV4 More Efficiently than AAV5*

J. Chiorini, J. Pilewski, J. Zabner, 2002, The Journal of Biological Chemistry.

Correction of cAMP-stimulated fluid secretion in cystic fibrosis airway epithelia: efficiency of adenovirus-mediated gene transfer in vitro.

Alan E. Smith, J. Zabner, M. Welsh, 1994, Human gene therapy.

Recombinant adeno-associated virus type 2, 4, and 5 vectors: transduction of variant cell types and regions in the mammalian central nervous system.

I. Martins, R. Kotin, B. Davidson, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Cationic lipid-mediated transfer of the hIL-10 gene prolongs survival of allogeneic hepatocytes in Nagase analbuminemic rats.

A. Fabrega, J. Zabner, A. Fasbender, 1996, Transplantation.

Cationic lipid mediated gene transfer of CFTR: safety of a single administration to the nasal epithelia.

M. Welsh, J. Zabner, 1999, Human gene therapy.

Disruption of the circadian rhythm of melatonin: A biomarker of critical illness severity.

P. T. Ten Eyck, E. van Cauter, A. Pohlman, 2023, Sleep medicine.

Intestinal CFTR expression alleviates meconium ileus in cystic fibrosis pigs.

E. Hoffman, D. Meyerholz, M. Welsh, 2013, The Journal of clinical investigation.

Disruption of the CFTR Gene Produces a Model of Cystic Fibrosis in Newborn Pigs

D. Meyerholz, M. Welsh, C. Murphy, 2008, Science.

Impaired mucus detachment disrupts mucociliary transport in a piglet model of cystic fibrosis

E. Hoffman, M. Welsh, T. Moninger, 2014, Science.

Concentration of the antibacterial precursor thiocyanate in cystic fibrosis airway secretions.

M. Welsh, D. Stoltz, J. Zabner, 2011, Free Radical Biology & Medicine.

Pigs and humans with cystic fibrosis have reduced insulin-like growth factor 1 (IGF1) levels at birth

M. Welsh, R. Prather, M. Rogan, 2010, Proceedings of the National Academy of Sciences.

Transduction of Pig Small Airway Epithelial Cells and Distal Lung Progenitor Cells by AAV4

D. Stoltz, J. Zabner, R. Girgis, 2021, Cells.

Adenovirus-Mediated Gene Transfer for Cystic Fibrosis: Part A. Safety of Dose and Repeat Administration in the Nasal Epithelium. Part B. Clinical Efficacy in the Maxillary Sinus. Howard Hughes Medical Institute, Iowa City, Iowa

M. Welsh, Alan E. Smith, J. Zabner, 1995 .

Ivacaftor-induced sweat chloride reductions correlate with increases in airway surface liquid pH in cystic fibrosis.

M. Welsh, D. Stoltz, J. Zabner, 2018, JCI insight.

Large-scale gene discovery in human airway epithelia reveals novel transcripts.

T. Scheetz, M. Welsh, J. Zabner, 2004, Physiological genomics.

Reovirus preferentially infects the basolateral surface and is released from the apical surface of polarized human respiratory epithelial cells.

J. Zabner, J. Wetzel, Jacquelyn A. Campbell, 2008, The Journal of infectious diseases.

Tryptase Does Not Alter Transepithelial Conductance or Paracellular Permeability in Human Airway Epithelial Cells

J. Zabner, John H. Lee, Eugene H. Chang, 2010, American Journal of Rhinology & Allergy.

The Effects of Fluticasone Propionate on Nasal Epithelial Potential Difference

J. Zabner, S. Graham, S. N. Scott, 2002, American journal of rhinology.

Polarized AAVR expression determines infectivity by AAV gene therapy vectors

J. Zabner, A. Pezzulo, M. A. Abou Alaiwa, 2019, Gene Therapy.