B. Degrève

发表

Mutation of Gln125 to Asn selectively abolishes the thymidylate kinase activity of herpes simplex virus type 1 thymidine kinase.

R. Esnouf, E. De Clercq, B. Degrève, 2001, Molecular pharmacology.

Selective abolishment of pyrimidine nucleoside kinase activity of herpes simplex virus type 1 thymidine kinase by mutation of alanine-167 to tyrosine.

R. Esnouf, E. De Clercq, B. Degrève, 2000, Molecular pharmacology.

Characterization of multiple nuclear localization signals in herpes simplex virus type 1 thymidine kinase.

R. Esnouf, E. De Clercq, B. Degrève, 1999, Biochemical and biophysical research communications.

Efficacy of antiherpetic drugs in combined gene/chemotherapy of cancer is not affected by a specific nuclear or cytoplasmic compartmentation of herpes thymidine kinases

B. Degrève, J. Balzarini, E. Clercq, 1999 .

Varicella-zoster virus thymidine kinase gene and antiherpetic pyrimidine nucleoside analogues in a combined gene/chemotherapy treatment for cancer

M. Izquierdo, J. Piette, B. Degrève, 1997, Gene Therapy.

Superior cytostatic activity of the ganciclovir elaidic acid ester due to the prolonged intracellular retention of ganciclovir anabolites in herpes simplex virus type 1 thymidine kinase gene-transfected tumor cells

J. Neyts, B. Degrève, J. Balzarini, 1998, Gene Therapy.

Bystander effect of purine nucleoside analogues in HSV-1tk suicide gene therapy is superior to that of pyrimidine nucleoside analogues

B. Degrève, J. Balzarini, E. D. Clercq, 1999, Gene Therapy.

Cloning and Characterization of the Multisubstrate Deoxyribonucleoside Kinase of Drosophila melanogaster *

B. Degrève, J. Balzarini, A. Karlsson, 1999, The Journal of Biological Chemistry.

Improving AZT efficacy

B. Degrève, J. Balzarini, E. D. Clercq, 1998, Nature Medicine.

Comparative in vitro and in vivo cytotoxic activity of (E)-5-(2-bromovinyl)-2′-deoxyuridine (BVDU) and its arabinosyl derivative, (E)-5-(2-bromovinyl)-1-β-D-arabinofuranosyluracil (BVaraU), against tumor cells expressing either the Varicella zoster or the Herpes simplex virus thymidine kinase

T. Velu, B. Degrève, J. Balzarini, 2000, Cancer Gene Therapy.

Better Preservation of the Peritoneum in Rats Exposed to Amino Acid-Based Peritoneal Dialysis Fluid

J. van den Born, B. Degrève, G. Tangelder, 2005, Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis.

The sulfonic acid polymers PAMPS [poly(2-acrylamido-2-methyl-1-propanesulfonic acid)] and related analogues are highly potent inhibitors of angiogenesis.

E. De Clercq, J. Neyts, B. Degrève, 1997, Oncology research.

Selection of HSV-1 TK gene-transfected murine mammary carcinoma cells resistant to (E)-5-(2-bromovinyl)-2′-deoxyuridine (BVDU) and ganciclovir (GCV)

B. Degrève, J. Balzarini, E. D. Clercq, 2000, Gene Therapy.

Budding yeast as a screening tool for discovery of nucleoside analogs for use in HSV-1 TK suicide-gene therapy.

J. Thevelein, E. De Clercq, J. Neyts, 1999, BioTechniques.

Crystal Structure of Varicella Zoster Virus Thymidine Kinase*

Jan Balzarini, Louise E. Bird, D. Stammers, 2003, Journal of Biological Chemistry.

The multifunctional deoxynucleoside kinase of insect cells is a target for the development of new insecticides.

E. De Clercq, B. Degrève, J. Balzarini, 2000, Molecular pharmacology.

ACYCLIC/CARBOCYCLIC GUANOSINE ANALOGUES AS ANTI-HERPESVIRUS AGENTS

P Leyssen, E. De Clercq, L. Naesens, 2001 .

Behavior of Thymidylate Kinase toward Monophosphate Metabolites and Its Role in the Metabolism of 1-(2′-Deoxy-2′-Fluoro-β-l-Arabinofuranosyl)-5-Methyluracil (Clevudine) and 2′,3′-Didehydro-2′,3′-Dideoxythymidine in Cells

B. Degrève, W. Lam, Rong Hu, 2005, Antimicrobial Agents and Chemotherapy.

Potent antitumor activity of the acyclic nucleoside phosphonate 9‐(2‐phosphonylmethoxyethyl)adenine in choriocarcinoma‐bearing rats

E. De Clercq, L. Naesens, B. Degrève, 1998, International journal of cancer.

In vitro and in vivo inhibitory activity of the differentiation-inducing agent 9-(2-phosphonylmethoxyethyl)adenine (PMEA) against rat choriocarcinoma.

E. De Clercq, L. Naesens, B. Degrève, 1998, Advances in experimental medicine and biology.

2'-O-Acyl/alkyl-substituted arabinosyl nucleosides as inhibitors of human mitochondrial thymidine kinase.

L. Porcu, B. Degrève, A. Karlsson, 2001, Biochemical pharmacology.

Differential Intracellular Compartmentalization of Herpetic Thymidine Kinases (TKs) in TK Gene-Transfected Tumor Cells: Molecular Characterization of the Nuclear Localization Signal of Herpes Simplex Virus Type 1 TK

E. De Clercq, B. Degrève, J. Balzarini, 1998, Journal of Virology.

Kinetic analysis of novel multisubstrate analogue inhibitors of thymidine phosphorylase

R. Esnouf, E. De Clercq, B. Degrève, 2000, FEBS letters.

Acyclic/Carbocyclic Guanosine Analogues as Anti‐Herpesvirus Agents

L. Naesens, B. Degrève, J. Balzarini, 2001 .

ACYCLIC/CARBOCYCLIC GUANOSINE ANALOGUES AS ANTI-HERPESVIRUS AGENTS

L. Naesens, J. Neyts, B. Degrève, 2001 .