J. Balzarini

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Mutation of Gln125 to Asn selectively abolishes the thymidylate kinase activity of herpes simplex virus type 1 thymidine kinase.

R. Esnouf, E. De Clercq, B. Degrève, 2001, Molecular pharmacology.

Selective abolishment of pyrimidine nucleoside kinase activity of herpes simplex virus type 1 thymidine kinase by mutation of alanine-167 to tyrosine.

R. Esnouf, E. De Clercq, B. Degrève, 2000, Molecular pharmacology.

Characterization of multiple nuclear localization signals in herpes simplex virus type 1 thymidine kinase.

R. Esnouf, E. De Clercq, B. Degrève, 1999, Biochemical and biophysical research communications.

Efficacy of antiherpetic drugs in combined gene/chemotherapy of cancer is not affected by a specific nuclear or cytoplasmic compartmentation of herpes thymidine kinases

B. Degrève, J. Balzarini, E. Clercq, 1999 .

Potential of carbohydrate‐binding agents as therapeutics against enveloped viruses

J. Balzarini, K. François, J Balzarini, 2010, Medicinal research reviews.

Ether phospholipid-AZT conjugates possessing anti-HIV and antitumor cell activity. Synthesis, conformational analysis, and study of their thermal effects on membrane bilayers.

E. De Clercq, J. Balzarini, T. Mavromoustakos, 2001, Journal of medicinal chemistry.

The application of phosphoramidate protide technology to acyclovir confers anti-HIV inhibition.

A. Brancale, L. Margolis, J. Balzarini, 2009, Journal of medicinal chemistry.

Anti-HIV properties of cationic fullerene derivatives.

M. Prato, G. Spalluto, J. Balzarini, 2005, Bioorganic & medicinal chemistry letters.

Chlorofullerene C60Cl6: a precursor for straightforward preparation of highly water-soluble polycarboxylic fullerene derivatives active against HIV.

P. Troshin, J. Balzarini, R. Lyubovskaya, 2007, Organic & biomolecular chemistry.

Human glutaredoxin-1 catalyzes the reduction of HIV-1 gp120 and CD4 disulfides and its inhibition reduces HIV-1 replication.

J. Balzarini, J. Auwerx, Ola Isacsson, 2009, The international journal of biochemistry & cell biology.

with Alpha Interferon GTP Pools and Is Moderately Synergistic Replication through Depletion of Cellular Hepatitis E Virus In Vitro Ribavirin Inhibits

S. Emerson, J. Balzarini, Q. Pan, 2013 .

Ribavirin Inhibits In Vitro Hepatitis E Virus Replication through Depletion of Cellular GTP Pools and Is Moderately Synergistic with Alpha Interferon

S. Emerson, J. Neyts, J. Balzarini, 2013, Antimicrobial Agents and Chemotherapy.

Discovery of novel anti-HIV active G-quadruplex-forming oligonucleotides.

J. Balzarini, G. Di Fabio, J. D’Onofrio, 2011, Chemical communications.

Successful treatment of progressive mucocutaneous infection due to acyclovir- and foscarnet-resistant herpes simplex virus with (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC).

E. De Clercq, A. Silverman, J. Balzarini, 1994, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Thiosugars. Part 9: synthesis and biological evaluation of some 4'-thio-L-arabino nucleoside analogues.

E. De Clercq, J. Balzarini, J. Wirsching, 2001, Bioorganic & medicinal chemistry letters.

The Predominant Mechanism by Which Ribavirin Exerts Its Antiviral Activity In Vitro against Flaviviruses and Paramyxoviruses Is Mediated by Inhibition of IMP Dehydrogenase

E. De Clercq, J. Neyts, J. Balzarini, 2005, Journal of Virology.

Pyridine N-oxide derivatives are inhibitory to the human SARS and feline infectious peritonitis coronavirus in cell culture

E. De Clercq, M. Van Ranst, J. Balzarini, 2005, The Journal of antimicrobial chemotherapy.

Plant lectins are potent inhibitors of coronaviruses by interfering with two targets in the viral replication cycle

C. Pannecouque, M. Van Ranst, J. Balzarini, 2007, Antiviral Research.

NICTABA and UDA, two GlcNAc-binding lectins with unique antiviral activity profiles

J. Balzarini, D. Schols, E. V. Van Damme, 2015, The Journal of antimicrobial chemotherapy.

Potent antiviral activity of carbohydrate-specific algal and leguminous lectins from the Brazilian biodiversity† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8md00508g

P. Sadler, C. Nagano, K. Nascimento, 2019, MedChemComm.

A novel selective broad-spectrum anti-DNA virus agent

J. Balzarini, E. Clercq, A. Holý, 1986, Nature.

Photochemical studies and nanomolar photodynamic activities of phthalocyanines functionalized with 1,4,7-trioxanonyl moieties at their non-peripheral positions.

M. Wierzchowski, J. Balzarini, T. Goslinski, 2016, Journal of inorganic biochemistry.

Regioselective addition reactions at C-2 of 3,4-dihydropyrimidinones. Synthesis and evaluation of multifunctionalized tetrahydropyrimidines

D. Arora, J. Balzarini, Kamaljit Singh, 2010 .

Screening Platform toward New Anti-HIV Aptamers Set on Molecular Docking and Fluorescence Quenching Techniques.

E. Novellino, P. Grieco, G. Piccialli, 2016, Analytical chemistry.

Carbohydrate‐binding agents act as potent trypanocidals that elicit modifications in VSG glycosylation and reduced virulence in Trypanosoma brucei

J. Balzarini, E. V. Van Damme, A. E. Vidal, 2013, Molecular microbiology.

Potentiating effect of (2-[2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methyl]-phenyl]ethenyl) -phosphonic acid (MDL 74,428), a potent inhibitor of purine nucleoside phosphorylase, on the antiretroviral activities of 2',3'-dideoxyinosine combined with ribavirin in mice.

A. Bernhardt, J. Balzarini, M. Weibel, 1994, Biochemical pharmacology.

Dose-response relationship in cyclophosphamide-treated B-cell lymphoma xenografts monitored with [18F]FDG PET

F. Mottaghy, L. Mortelmans, L. Brepoels, 2010, European Journal of Nuclear Medicine and Molecular Imaging.

Synthesis and anti-HIV-1 and anti-HCMV activity of 1-substituted 3-(3,5-dimethylbenzyl)uracil derivatives.

E. De Clercq, C. Pannecouque, J. Balzarini, 2006, Chemical & pharmaceutical bulletin.

Isolation and characterization of a small antiretroviral molecule affecting HIV-1 capsid

S. Höglund, Á. Végvári, J. Balzarini, 2009 .

Isolation and characterization of a small antiretroviral molecule affecting HIV-1 capsid morphology

S. Höglund, Á. Végvári, J. Balzarini, 2009, Retrovirology.

Activity of the Small Modified Amino Acid α-Hydroxy Glycineamide on In Vitro and In Vivo Human Immunodeficiency Virus Type 1 Capsid Assembly and Infectivity

S. Höglund, Á. Végvári, E. Andersson, 2008, Antimicrobial Agents and Chemotherapy.

Antiviral Activity of Synthetic Aminopyrrolic Carbohydrate Binding Agents: Targeting the Glycans of Viral gp120 to Inhibit HIV Entry.

J. Balzarini, S. Noppen, S. Liekens, 2015, Chemistry.

Chiral resolution, absolute configuration assignment and biological activity of racemic diarylpyrimidine CH(OH)-DAPY as potent nonnucleoside HIV-1 reverse transcriptase inhibitors.

E. De Clercq, C. Pannecouque, Xiaodong Ma, 2012, European journal of medicinal chemistry.

4-[1-(Substituted aryl/alkyl carbonyl)-benzoimidazol-2-yl]-benzenesulfonic acids: Synthesis, antimicrobial activity, QSAR studies, and antiviral evaluation

B. Narasimhan, E. De Clercq, C. Pannecouque, 2010, European Journal of Medicinal Chemistry.

Synthesis and Antiviral Activity of Water‐Soluble Polycarboxylic Derivatives of [60]Fullerene Loaded with 3,4‐Dichlorophenyl Units

P. Troshin, J. Balzarini, D. Schols, 2018, Chemistry & biodiversity.

Carbohydrate-Binding Agents Efficiently Prevent Dendritic Cell-Specific Intercellular Adhesion Molecule-3-Grabbing Nonintegrin (DC-SIGN)-Directed HIV-1 Transmission to T Lymphocytes

G. Vanham, J. Balzarini, D. Schols, 2007, Molecular Pharmacology.

Synthesis and antiviral activities of new acyclic and "double-headed" nucleoside analogues.

E. De Clercq, J. Neyts, J. Balzarini, 2007, Bioorganic chemistry.

Simian Immunodeficiency Virus Is Susceptible to Inhibition by Carbohydrate-Binding Agents in a Manner Similar to That of HIV: Implications for Further Preclinical Drug Development

J. Balzarini, D. Schols, K. François, 2008, Molecular Pharmacology.

Rational design of 5'-thiourea-substituted alpha-thymidine analogues as thymidine monophosphate kinase inhibitors capable of inhibiting mycobacterial growth.

Jan Balzarini, Hélène Munier-Lehmann, Matheus Froeyen, 2007, Journal of medicinal chemistry.

Synthesis, modeling and evaluation of 3'-(1-aryl-1H-tetrazol-5-ylamino)-substituted 3'-deoxythymidine derivatives as potent and selective human mitochondrial thymidine kinase inhibitors.

S. van Calenbergh, F. Gago, J. Balzarini, 2011, Organic & biomolecular chemistry.

Design, Synthesis, and Biological Evaluation of Novel 2H‐Pyran‐2‐one Derivatives as Potential HIV‐1 Reverse Transcriptase Inhibitors

A. Defant, J. Balzarini, I. Mancini, 2015, Archiv der Pharmazie.

Synthesis and Anti Hiv-1 Reverse Transcriptase Evaluation of A Series of N-Mono Substituted Thiourea Derivatives

C. Pannecouque, J. Balzarini, E. Clercq, 2015 .

5′-O-Tritylated Nucleoside Derivatives: Inhibition of Thymidine Phosphorylase and Angiogenesis

J. Balzarini, A. Bronckaers, S. Liekens, 2006, Molecular Pharmacology.

Metabolism and mechanism of antiretroviral action of purine and pyrimidine derivatives

J. Balzarini, 1994, Pharmacy World and Science.

Retention of marked sensitivity to (S)-4-isopropoxycarbonyl-6-methoxy-3-(methylthiomethyl)-3,4-di hydroquin oxaline-2(1H)-thione (HBY 097) by an azidothymidine (AZT)-resistant human immunodeficiency virus type 1 (HIV-1) strain subcultured in the combined presence of quinoxaline HBY 097 and 2',3'-did

E. De Clercq, J. Balzarini, M. Roesner, 1998, Biochemical pharmacology.

Analysis of inhibition of retroviral reverse transcriptase.

E. De Clercq, J. Balzarini, 1996, Methods in enzymology.

Inhibitory activity of S-adenosylhomocysteine hydrolase inhibitors against human cytomegalovirus replication.

E. De Clercq, J. Neyts, J. Balzarini, 1993, Antiviral Research.

Single-dose administration of 9-(2-phosphonylmethoxyethyl)adenine (PMEA) and 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP) in the prophylaxis of retrovirus infection in vivo.

E. De Clercq, L. Naesens, J. Balzarini, 1991, Antiviral research.

Non-nucleoside HIV-1 reverse transcriptase inhibitors, Part 7. Synthesis, antiviral activity, and 3D-QSAR investigations of novel 6-(1-naphthoyl) HEPT analogues.

E. De Clercq, C. Pannecouque, J. Balzarini, 2006, Chemical & pharmaceutical bulletin.

Zidovudine-resistant human immunodeficiency virus type 1 strains subcultured in the presence of both lamivudine and quinoxaline HBY 097 retain marked sensitivity to HBY 097 but not to lamivudine.

E. De Clercq, J. Balzarini, M. Roesner, 1997, The Journal of infectious diseases.

Multiple drug resistance to nucleoside analogues and nonnucleoside reverse transcriptase inhibitors in an efficiently replicating human immunodeficiency virus type 1 patient strain.

E. De Clercq, A. Vandamme, J. Balzarini, 1996, The Journal of infectious diseases.

The Griffithsin Dimer Is Required for High-Potency Inhibition of HIV-1: Evidence for Manipulation of the Structure of gp120 as Part of the Griffithsin Dimer Mechanism

J. Balzarini, B. Hoorelbeke, B. Demeler, 2013, Antimicrobial Agents and Chemotherapy.

DC-SIGN Increases the Affinity of HIV-1 Envelope Glycoprotein Interaction with CD4

Yufei Wang, G. Vanham, C. Kelly, 2011, PloS one.

Inhibition of HIV-1 Env-Mediated Cell-Cell Fusion by Lectins, Peptide T-20, and Neutralizing Antibodies

J. Balzarini, N. Düzgüneş, K. Konopka, 2011, The open virology journal.

New anti-HIV aptamers based on tetra-end-linked DNA G-quadruplexes: effect of the base sequence on anti-HIV activity.

G. Piccialli, S. Haider, J. Balzarini, 2012, Chemical communications.

Synthesis, antimycobacterial, antiviral, antimicrobial activities, and QSAR studies of isonicotinic acid-1-(substituted phenyl)-ethylidene/cycloheptylidene hydrazides

B. Narasimhan, P. Yogeeswari, D. Sriram, 2011, Medicinal Chemistry Research.

Isonicotinic acid hydrazide derivatives: synthesis, antimicrobial activity, and QSAR studies

B. Narasimhan, P. Yogeeswari, D. Sriram, 2012, Medicinal Chemistry Research.

Benzylidene/2-chlorobenzylidene hydrazides: Synthesis, antimicrobial activity, QSAR studies and antiviral evaluation

B. Narasimhan, E. De Clercq, J. Balzarini, 2010, European Journal of Medicinal Chemistry.

Physicochemical characterization of solid dispersions of the antiviral agent UC-781 with polyethylene glycol 6000 and Gelucire 44/14.

L. Naesens, J. Balzarini, P. Augustijns, 2000, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Profile of Resistance of Human Immunodeficiency Virus to Mannose-Specific Plant Lectins

E. De Clercq, A. Vandamme, K. Van Laethem, 2004, Journal of Virology.

Fluorosubstitution and 7-alkylation as prospective modifications of biologically active 6-aryl derivatives of tricyclic acyclovir and ganciclovir analogues.

E. De Clercq, J. Balzarini, B. Golankiewicz, 2005, Bioorganic & medicinal chemistry.

Synthesis, Antiviral and Cytostatic Evaluation of Unsaturated Exomethylene and Keto D‐Lyxopyranonucleoside Analogues

J. Balzarini, S. Manta, D. Komiotis, 2009, Archiv der Pharmazie.

3'-substituted 2',3'-dideoxynucleoside analogues as potential anti-HIV (HTLV-III/LAV) agents.

E. De Clercq, R. Pauwels, P. Herdewijn, 1987, Journal of medicinal chemistry.

Synthesis and biological evaluation of 2',3'-dideoxy-3'-fluororibofuranosyl purine nucleosides

J. Balzarini, E. Clercq, Z. Kazimierczuk, 1997 .

Anti-Hiv-1 Activity of 2′,3′-Dideoxinucleoside Analogues : Structure-Activity Relationship

R. Pauwels, P. Herdewijn, A. Aerschot, 1989 .

Novel 1,2,4-triazole and Purine Acyclic Cyclopropane Nucleoside Analogues: Synthesis, Antiviral and Cytostatic Activity Evaluations

K. Pavelić, J. Balzarini, K. Wittine, 2011, Antiviral Chemistry & Chemotherapy.

Synthesis and antiviral activity of monofluorinated cyclopropanoid nucleosides.

E. De Clercq, J. Balzarini, G. Haufe, 2004, Organic & biomolecular chemistry.

Activity and safety of synthetic lectins based on benzoboroxole-functionalized polymers for inhibition of HIV entry.

J. Balzarini, P. Kiser, Alamelu Mahalingam, 2011, Molecular pharmaceutics.

Combinations of griffithsin with other carbohydrate-binding agents demonstrate superior activity against HIV Type 1, HIV Type 2, and selected carbohydrate-binding agent-resistant HIV Type 1 strains.

M. Swanson, D. Markovitz, J. Balzarini, 2012, AIDS Research and Human Retroviruses.

Synthesis and antiherpes virus activity of 1,5-anhydrohexitol nucleosides.

E. De Clercq, P. Herdewijn, G. Janssen, 1993, Journal of medicinal chemistry.

Synthesis of triterpenoid triazine derivatives from allobetulone and betulonic acid with biological activities.

W. Dehaen, A. Mashentseva, J. Balzarini, 2014, Bioorganic & medicinal chemistry.

Human immunodeficiency virus type 1 reverse transcriptase dimer destabilization by 1-[Spiro[4"-amino-2",2" -dioxo-1",2" -oxathiole-5",3'-[2', 5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]]]-3-ethylthy mine.

J. Balzarini, M. Camarasa, N. Sluis-Cremer, 2000, Biochemistry.

Discovery and SAR studies of a novel class of cytotoxic 1,4-disubstituted piperidines via Ugi reaction.

J. Balzarini, S. de Castro, M. Camarasa, 2014, European journal of medicinal chemistry.

Carrier-Mediated Delivery of 9-(2-Phosphonylmethoxyethyl)Adenine to Parenchymal Liver Cells: a Novel Therapeutic Approach for Hepatitis B

T. V. van Berkel, J. Balzarini, R. D. de Vrueh, 2000, Antimicrobial Agents and Chemotherapy.

Cyclosal-pronucleotides--development of first and second generation chemical trojan horses for antiviral chemotherapy.

J. Balzarini, C. Meier, A. Meerbach, 2004, Frontiers in bioscience : a journal and virtual library.

Synthesis, Structural Studies, and Biological Evaluation of Some Purine Substituted 1-Aminocyclopropane-1-carboxylic Acids and 1-Amino-1-hydroxymethylcyclopropanes

E. De Clercq, K. Pavelić, N. Slade, 2003, Nucleosides, nucleotides & nucleic acids.

S-Adenosyl-L-homocysteine Hydrolase Inhibitors as Anti-Viral Agents: 5′-Deoxyaristeromycin

S. Ikeda, J. Balzarini, E. Clercq, 1993 .

The anti-HTLV-III (anti-HIV) and cytotoxic activity of 2',3'-didehydro-2',3'-dideoxyribonucleosides: a comparison with their parental 2',3'-dideoxyribonucleosides.

E. De Clercq, P. Herdewijn, S. Broder, 1987, Molecular pharmacology.

1-[2-(2-Benzoyl- and 2-benzylphenoxy)ethyl]uracils as potent anti-HIV-1 agents

A. V. Ivanov, C. Pannecouque, J. Balzarini, 2011, Bioorganic & Medicinal Chemistry.

Fused heterocycles bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 3: optimization of [1,2,4]triazolo[1,5-a]pyrimidine core via structure-based and physicochemical property-driven approaches.

E. De Clercq, Boshi Huang, Huiqing Liu, 2015, European journal of medicinal chemistry.

Varicella-zoster virus thymidine kinase gene and antiherpetic pyrimidine nucleoside analogues in a combined gene/chemotherapy treatment for cancer

M. Izquierdo, J. Piette, B. Degrève, 1997, Gene Therapy.

Superior cytostatic activity of the ganciclovir elaidic acid ester due to the prolonged intracellular retention of ganciclovir anabolites in herpes simplex virus type 1 thymidine kinase gene-transfected tumor cells

J. Neyts, B. Degrève, J. Balzarini, 1998, Gene Therapy.

Bystander effect of purine nucleoside analogues in HSV-1tk suicide gene therapy is superior to that of pyrimidine nucleoside analogues

B. Degrève, J. Balzarini, E. D. Clercq, 1999, Gene Therapy.

Ribavirin antagonizes inhibitory effects of pyrimidine 2',3'-dideoxynucleosides but enhances inhibitory effects of purine 2',3'-dideoxynucleosides on replication of human immunodeficiency virus in vitro

E. De Clercq, R. Pauwels, P. Herdewijn, 1987, Antimicrobial Agents and Chemotherapy.

Mutational analysis of trp-229 of human immunodeficiency virus type 1 reverse transcriptase (RT) identifies this amino acid residue as a prime target for the rational design of new non-nucleoside RT inhibitors.

R. Esnouf, E. De Clercq, J. Balzarini, 2000, Molecular pharmacology.

[18F]FDG and [18F]FLT uptake in human breast cancer cells in relation to the effects of chemotherapy: an in vitro study

A. Lammertsma, A. Lammertsma, M. Spreeuwenberg, 2008, British Journal of Cancer.

Meningoradiculoneuritis due to acyclovir‐resistant varicella zoster virus in an acquired immune deficiency syndrome patient

E. De Clercq, J. Piette, J. Balzarini, 1994, Journal of medical virology.

Synthesis and Antiviral Activities of 3-Aralkyl-Thiomethylimidazo[1,2-b]Pyridazine Derivatives

E. De Clercq, C. Pannecouque, J. Balzarini, 2003, Antiviral chemistry & chemotherapy.

Enzymatic phosphorylation and pyrophosphorylation of 2',3'-dideoxyadenosine-5'-monophosphate, a key metabolite in the pathway for activation of the anti-HIV (human immunodeficiency virus) agent 2',3'-dideoxyinosine.

J. Balzarini, S. Halazy, J. Navé, 1994, Biochemical pharmacology.

Differential activity of candidate microbicides against early steps of HIV-1 infection upon complement virus opsonization

C. Charpentier, G. Vanham, J. Balzarini, 2010, AIDS research and therapy.

Novel 5-Arylcarbamoyl-2-methylisoxazolidin-3-yl-3-phosphonates as Nucleotide Analogues

J. Balzarini, D. Piotrowska, Kamil Kokosza, 2014, Nucleosides, nucleotides & nucleic acids.

Design, Synthesis, Antiviral, and Cytostatic Evaluation of Novel Isoxazolidine Analogues of C-Nucleotides

J. Balzarini, D. Piotrowska, Magdalena Grabkowska-Drużyc, 2013, Nucleosides, nucleotides & nucleic acids.

Metabolic activation of nucleoside and nucleotide reverse transcriptase inhibitors in dendritic and Langerhans cells

G. Vanham, J. Balzarini, Y. van Herrewege, 2002, AIDS.

Activity of reverse transcriptase inhibitors in monocyte-derived dendritic cells: a possible in vitro model for postexposure prophylaxis of sexual HIV transmission.

G. Vanham, J. Balzarini, L. Kestens, 2002, AIDS research and human retroviruses.

Novel platinum(II) and palladium(II) complexes of thiosemicarbazones derived from 5-substitutedthiophene-2-carboxaldehydes and their antiviral and cytotoxic activities

J. Balzarini, E. E. Oruç-Emre, D. Taşdemir, 2011, European Journal of Medicinal Chemistry.

Design, synthesis, and biological evaluation of hybrid molecules containing alpha-methylene-gamma-butyrolactones and polypyrrole minor groove binders.

E. De Clercq, J. Balzarini, P. Baraldi, 2004, Journal of medicinal chemistry.

Discovery of 2,3-diaryl-1,3-thiazolidin-4-ones as potent anti-HIV-1 agents.

E. De Clercq, C. Pannecouque, J. Balzarini, 2001, Bioorganic & medicinal chemistry letters.

Design, synthesis, structure-activity relationships, and molecular modeling studies of 2,3-diaryl-1,3-thiazolidin-4-ones as potent anti-HIV agents.

E. De Clercq, C. Pannecouque, J. Balzarini, 2002, Journal of Medicinal Chemistry.

Anti-HIV activity of N-1-adamantyl-4-aminophthalimide.

E. De Clercq, J. Poupaert, J. Balzarini, 1997, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Synthesis and biological evaluation of unsaturated keto and exomethylene D-arabinopyranonucleoside analogs: novel 5-fluorouracil analogs that target thymidylate synthase.

J. Balzarini, S. Liekens, S. Manta, 2011, European journal of medicinal chemistry.

Crystal structure of poxvirus thymidylate kinase: An unexpected dimerization has implications for antiviral therapy

S. Pochet, J. Balzarini, P. Meyer, 2008, Proceedings of the National Academy of Sciences.

Potent and selective inhibition of human immunodeficiency virus (HIV)-1 and HIV-2 replication by a class of bicyclams interacting with a viral uncoating event.

E. De Clercq, R. Pauwels, M. Baba, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Synthesis and biological evaluation of 2-(5-substituted-1-((diethylamino)methyl)-2-oxoindolin-3-ylidene)-N-substituted-hydrazinecarbothioamides

E. De Clercq, J. Balzarini, Sujeet Kumar, 2012, Medicinal Chemistry Research.

Differential inhibitory effects of sulfated polysaccharides and polymers on the replication of various myxoviruses and retroviruses, depending on the composition of the target amino acid sequences of the viral envelope glycoproteins

E. De Clercq, M. Hosoya, J. Balzarini, 1991, Antimicrobial Agents and Chemotherapy.

Structure of vaccinia virus thymidine kinase in complex with dTTP: insights for drug design

D. Stammers, J. Balzarini, A. Karlsson, 2006, BMC Structural Biology.

Direct arylation of C60Cl6 and C70Cl8 with carboxylic acids: a synthetic avenue to water-soluble fullerene derivatives with promising antiviral activity.

P. Troshin, I. Godovikov, J. Balzarini, 2019, Chemical communications.

1,2,3-Triazole-[2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D- ribofuranosyl]-3'-spiro-5"-(4"-amino-1",2"-oxathiole 2",2"-dioxide) (TSAO) analogues: synthesis and anti-HIV-1 activity.

E. De Clercq, C. Perno, J. Balzarini, 1994, Journal of medicinal chemistry.

An emerging understanding of the Janus face of the human microbiome: enhancement versus impairment of cancer therapy.

J. Balzarini, S. Liekens, J. Vande Voorde, 2014, The Journal of antimicrobial chemotherapy.

Nucleoside-catabolizing Enzymes in Mycoplasma-infected Tumor Cell Cultures Compromise the Cytostatic Activity of the Anticancer Drug Gemcitabine*

S. Fieuws, J. Balzarini, S. Noppen, 2014, The Journal of Biological Chemistry.

Pharmacokinetics in mice of the anti-retrovirus agent 9-(2-phosphonylmethoxyethyl)adenine.

E. De Clercq, L. Naesens, J. Balzarini, 1992, Drug metabolism and disposition: the biological fate of chemicals.

Intracellular metabolism and mechanism of anti-retrovirus action of 9-(2-phosphonylmethoxyethyl)adenine, a potent anti-human immunodeficiency virus compound.

E. De Clercq, P. Herdewijn, J. Balzarini, 1991, Proceedings of the National Academy of Sciences of the United States of America.

5-Phosphoribosyl 1-pyrophosphate synthetase converts the acyclic nucleoside phosphonates 9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine and 9-(2-phosphonylmethoxyethyl)adenine directly to their antivirally active diphosphate derivatives.

E. De Clercq, J. Balzarini, 1991, The Journal of biological chemistry.

The Highly Autoaggregative and Adhesive Phenotype of the Vaginal Lactobacillus plantarum Strain CMPG5300 Is Sortase Dependent

R. Siezen, M. Vaneechoutte, S. Lebeer, 2013, Applied and Environmental Microbiology.

ProTides of N-(3-(5-(2'-deoxyuridine))prop-2-ynyl)octanamide as potential anti-tubercular and anti-viral agents.

J. Balzarini, S. Bhakta, Marco Derudas, 2014, Bioorganic & medicinal chemistry.

Synthesis and cytostatic evaluation of 4-N-alkanoyl and 4-N-alkyl gemcitabine analogues.

J. Balzarini, S. Wnuk, Adam J. Sobczak, 2014, Journal of medicinal chemistry.

Novel 6-Azapyrimidine-2′-Deoxy-4′-Thionucleosides: Synthesis, Biological Evaluation and Conformational Analysis

E. De Clercq, J. Balzarini, C. Simons, 1999, Antiviral chemistry & chemotherapy.

Prognostic value of pretransplantation positron emission tomography using fluorine 18-fluorodeoxyglucose in patients with aggressive lymphoma treated with high-dose chemotherapy and stem cell transplantation.

P. Dupont, L. Mortelmans, G. Bormans, 2003, Blood.

Coexpression and interaction of CXCL10 and CD26 in mesenchymal cells by synergising inflammatory cytokines: CXCL8 and CXCL10 are discriminative markers for autoimmune arthropathies

M. Parmentier, G. Opdenakker, P. Proost, 2006, Arthritis research & therapy.

Design, synthesis and biological evaluation of novel curcumin analogues as anti-neoplastic agents

A. Jha, J. Balzarini, E. Clercq, 2006 .

Stromal cell-derived factor 1 (CXCL12) binds to endothelial cells and signals through a receptor different from CXCR4.

J. Balzarini, S. Liekens, S. Hatse, 2006, Biochemical and biophysical research communications.

Discovery of 8-methoxypyrazino[1,2-a]indole as a New Potent Antiproliferative Agent Against Human Leukemia K562 Cells. A Structure-Activity Relationship Study.

R. Gambari, E. Fabbri, O. Cruz-López, 2009, Letters in drug design & discovery.

Synthesis, biophysical characterization and anti-HIV activity of d(TG3AG) Quadruplexes bearing hydrophobic tails at the 5'-end.

J. Balzarini, D. Milardi, C. La Rosa, 2014, Bioorganic & medicinal chemistry.

Synthesis and antiviral activity of benzyl-substituted imidazo [1,5-a]-1,3,5-triazine (5,8-diaza-7,9-dideazapurine) derivatives.

E. De Clercq, S. Ikeda, J. Balzarini, 1995, Journal of medicinal chemistry.

Lectin-Like Molecules of Lactobacillus rhamnosus GG Inhibit Pathogenic Escherichia coli and Salmonella Biofilm Formation

S. Lebeer, J. Vanderleyden, J. Balzarini, 2016, PloS one.

Synthesis and biological properties of C-2 triazolylinosine derivatives.

J. Balzarini, B. Day, G. Andrei, 2012, The Journal of organic chemistry.

Novel NSAID 1-acyl-4-cycloalkyl/arylsemicarbazides and 1-acyl-5-benzyloxy/hydroxy carbamoylcarbazides as potential anticancer agents and antioxidants

D. Hadjipavlou-Litina, J. Balzarini, I. Martin-Kleiner, 2012, European Journal of Medicinal Chemistry.

Evaluation of in vitro biological activity of O-alkylated hydroxamic derivatives of some nonsteroidal anti-inflammatory drugs.

K. Pavelić, J. Balzarini, S. K. Pavelić, 2010, Anticancer research.

The novel amidocarbamate derivatives of ketoprofen: synthesis and biological activity

D. Hadjipavlou-Litina, J. Balzarini, E. Pontiki, 2010, Medicinal Chemistry Research.

The novel phosphoramidate derivatives of NSAID 3-hydroxypropylamides: synthesis, cytostatic and antiviral activity evaluations.

E. De Clercq, K. Pavelić, M. Kralj, 2009, European journal of medicinal chemistry.

Cytostatic and Antiviral Activity Evaluations of Hydroxamic Derivatives of Some Non‐steroidal Anti‐inflammatory Drugs

E. De Clercq, L. Naesens, K. Pavelić, 2009, Chemical Biology and Drug Design.

The ProTide Prodrug Technology: From the Concept to the Clinic

J. Balzarini, Y. Mehellou, Hardeep S Rattan, 2017, Journal of medicinal chemistry.

Facile transformation of Biginelli pyrimidin-2(1H)-ones to pyrimidines. In vitro evaluation as inhibitors of Mycobacterium tuberculosis and modulators of cytostatic activity.

K. Chibale, J. Balzarini, S. Franzblau, 2011, European journal of medicinal chemistry.

Structural motifs and biological studies of new antimony(III) iodide complexes with thiones.

J. Balzarini, A. Tasiopoulos, M. Manos, 2010, Inorganic chemistry.

Pradimicin S, a highly-soluble non-peptidic small-size carbohydrate-binding antibiotic,

J. Balzarini, D. Schols, S. Liekens, 2010 .

Targeting the glycans of glycoproteins: a novel paradigm for antiviral therapy

J. Balzarini, 2007, Nature Reviews Microbiology.

Comparative evaluation of the activity of antivirals towards feline immunodeficiency virus in different cell culture systems.

F. van der Meer, J. Balzarini, N. Schuurman, 2007, Antiviral research.

Anti-HIV and anti-HBV activity and resistance profile of 2',3'-dideoxy-3'-thiacytidine (3TC) and its arylphosphoramidate derivative CF 1109.

E. De Clercq, J. Balzarini, C. Mcguigan, 1996, Biochemical and biophysical research communications.

Synthesis and biological evaluation of 2-(2-deoxy-β-D-ribofuranosyl)pyridine-4-carboxamide

J. Balzarini, R. Dommisse, E. Esmans, 1992 .

Identification of aspartic acid-203 in human thymidine phosphorylase as an important residue for both catalysis and non-competitive inhibition by the small molecule "crystallization chaperone" 5'-O-tritylinosine (KIN59).

F. Gago, J. Balzarini, A. Bronckaers, 2009, Biochemical pharmacology.

Synthesis and biological evaluation of new conformationally restricted S-DABO hybrids as non-nucleoside inhibitors of HIV-1 reverse transcriptase

C. Pannecouque, J. Balzarini, E. Clercq, 2014 .

Synthesis and biological evaluation of novel 6-substituted 5-alkyl-2-(arylcarbonylmethylthio)pyrimidin-4(3H)-ones as potent non-nucleoside HIV-1 reverse transcriptase inhibitors.

E. De Clercq, C. Pannecouque, J. Balzarini, 2008, Bioorganic & medicinal chemistry.

Non‐Nucleoside HIV‐1 Reverse‐Transcriptase Inhibitors. Part 10

C. Pannecouque, J. Balzarini, Yue-ping Wang, 2008, Chemistry & biodiversity.

Nonnucleoside HIV-1 reverse transcriptase inhibitors; part 3. Synthesis and antiviral activity of 5-alkyl-2-[(aryl and alkyloxyl-carbonylmethyl)thio]-6-(1-naphthylmethyl) pyrimidin-4(3H)-ones.

E. De Clercq, C. Pannecouque, J. Balzarini, 2004, Bioorganic chemistry.

5-Alkyl-2-[(aryl and alkyloxylcarbonylmethyl)thio]-6-(1-naphthylmethyl) pyrimidin-4(3H)-ones as an unique HIV reverse transcriptase inhibitors of S-DABO series.

E. De Clercq, C. Pannecouque, J. Balzarini, 2004, Bioorganic & medicinal chemistry letters.

3'-[4-Aryl-(1,2,3-triazol-1-yl)]-3'-deoxythymidine analogues as potent and selective inhibitors of human mitochondrial thymidine kinase.

S. van Calenbergh, F. Gago, J. Balzarini, 2010, Journal of medicinal chemistry.

Cloning and Characterization of the Multisubstrate Deoxyribonucleoside Kinase of Drosophila melanogaster *

B. Degrève, J. Balzarini, A. Karlsson, 1999, The Journal of Biological Chemistry.

Improving AZT efficacy

B. Degrève, J. Balzarini, E. D. Clercq, 1998, Nature Medicine.

Synthesis and antiviral activity of the carbocyclic analogue of the highly potent and selective anti-VZV bicyclo furano pyrimidines.

J. Balzarini, C. Mcguigan, G. Andrei, 2007, Journal of Medicinal Chemistry.

Indolylarylsulfones bearing natural and unnatural amino acids. Discovery of potent inhibitors of HIV-1 non-nucleoside wild type and resistant mutant strains reverse transcriptase and coxsackie B4 virus.

E. Novellino, A. Lavecchia, A. Coluccia, 2009, Journal of medicinal chemistry.

Synthesis and Antitumor Molecular Mechanism of Agents Based on Amino 2‐(3′,4′,5′‐Trimethoxybenzoyl)benzo[b]furan: Inhibition of Tubulin and Induction of Apoptosis

A. Brancale, O. Cruz-López, J. Balzarini, 2011, ChemMedChem.

The role of individual carbohydrate-binding sites in the function of the potent anti-HIV lectin griffithsin.

J. Balzarini, B. Hoorelbeke, B. Demeler, 2012, Molecular pharmaceutics.

Drug targeting: anti-HSV-1 activity of mannosylated polymer-bound 9-(2-phosphonylmethoxyethyl)adenine.

E. De Clercq, M. Monsigny, J. Balzarini, 1990, Biochemical and biophysical research communications.

Use of a herpes thymidine kinase/neomycin phosphotransferase chimeric gene for metabolic suicide gene transfer

J. Balzarini, F. Candotti, R. Blaese, 2000, Cancer Gene Therapy.

Design, synthesis and structure-activity relationship of 2-(3',4',5'-trimethoxybenzoyl)-benzo[b]furan derivatives as a novel class of inhibitors of tubulin polymerization.

A. Brancale, O. Cruz-López, J. Balzarini, 2009, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of 2-amino-3-(3',4',5'-trimethoxybenzoyl)-6-substituted-4,5,6,7-tetrahydrothieno[2,3-c]pyridine derivatives as antimitotic agents and inhibitors of tubulin polymerization.

A. Brancale, O. Cruz-López, J. Balzarini, 2008, Bioorganic & medicinal chemistry letters.

Water-soluble fullerene-based nanostructures with promising antiviral and myogenic activity.

P. Troshin, J. Balzarini, D. Schols, 2020, Chemical communications.

9-(2-Phosphonylmethoxyethyl)adenine induces tumor cell differentiation or cell death by blocking cell cycle progression through the S phase.

E. De Clercq, J. Balzarini, D. Schols, 1999, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

Design, synthesis and evaluation of benzothiazole derivatives as multifunctional agents.

J. Balzarini, S. Liekens, S. Manfredini, 2020, Bioorganic chemistry.

between Antiherpesvirus Drugs Associations and Highlight Differences Genes Yield Novel Phenotype-Genotype Thymidine Kinase and DNA Polymerase Varicella-Zoster Virus Mutants in the-Selected Drug-Resistant In Vitro

G. Opdenakker, J. Balzarini, C. Mcguigan, 2012 .

In Vitro-Selected Drug-Resistant Varicella-Zoster Virus Mutants in the Thymidine Kinase and DNA Polymerase Genes Yield Novel Phenotype-Genotype Associations and Highlight Differences between Antiherpesvirus Drugs

G. Opdenakker, J. Balzarini, C. Mcguigan, 2011, Journal of Virology.

Alkyne-Azide Click Chemistry Mediated Carbanucleosides Synthesis

J. Neyts, J. Balzarini, S. Nolan, 2007, Nucleosides, nucleotides & nucleic acids.

Synthesis and NMR conformational studies of stable analogues of 2-deoxy-α-D-ribose-1-phosphate

J. Balzarini, M. Camarasa, M. Jimeno, 1998 .

Synthesis and evaluation of new antitumor 3-aminomethyl-4,11-dihydroxynaphtho[2,3-f]indole-5,10-diones.

Y. Pommier, M. Preobrazhenskaya, J. Balzarini, 2014, European journal of medicinal chemistry.

Cytostatic activity of novel 4'-aminochalcone-based imides.

E. De Clercq, A. Jha, J. Balzarini, 2007, Bioorganic & medicinal chemistry letters.

Targeting HIV entry through interaction with envelope glycoprotein 120 (gp120): synthesis and antiviral evaluation of 1,3,5-triazines with aromatic amino acids.

J. Balzarini, D. Schols, M. Camarasa, 2011, Journal of medicinal chemistry.

Design, synthesis, and enzymatic evaluation of multisubstrate analogue inhibitors of Escherichia coli thymidine phosphorylase.

R. Esnouf, E. De Clercq, A. Esteban-Gamboa, 2000, Journal of medicinal chemistry.

Novel 1,2,4-triazole and imidazole derivatives of L-ascorbic and imino-ascorbic acid: synthesis, anti-HCV and antitumor activity evaluations.

K. Pavelić, J. Plavec, J. Neyts, 2012, Bioorganic & Medicinal Chemistry.

Highly potent and selective inhibition of human immunodeficiency virus by the bicyclam derivative JM3100

E. De Clercq, R. Pauwels, B. Rosenwirth, 1994, Antimicrobial Agents and Chemotherapy.

Impact of 9‐(2‐phosphonylmethoxyethyl)adenine on (deoxy)ribonucleotide metabolism and nucleic acid synthesis in tumor cells

E. De Clercq, J. Balzarini, S. Hatse, 1999, FEBS letters.

Synthesis, antibacterial and antiviral properties of curcumin bioconjugates bearing dipeptide, fatty acids and folic acid

E. De Clercq, J. Balzarini, A. Bhargava, 2009, European Journal of Medicinal Chemistry.

Linear and branched alkyl-esters and amides of gallic acid and other (mono-, di- and tri-) hydroxy benzoyl derivatives as promising anti-HCV inhibitors.

J. Neyts, J. Balzarini, M. Camarasa, 2015, European journal of medicinal chemistry.

Comparative in vitro and in vivo cytotoxic activity of (E)-5-(2-bromovinyl)-2′-deoxyuridine (BVDU) and its arabinosyl derivative, (E)-5-(2-bromovinyl)-1-β-D-arabinofuranosyluracil (BVaraU), against tumor cells expressing either the Varicella zoster or the Herpes simplex virus thymidine kinase

T. Velu, B. Degrève, J. Balzarini, 2000, Cancer Gene Therapy.

Aryloxy Phosphoramidate Triesters: a Technology for Delivering Monophosphorylated Nucleosides and Sugars into Cells

J. Balzarini, C. Mcguigan, Y. Mehellou, 2009, ChemMedChem.

Synthesis and anti-HCMV activity of 1-acyl-beta-lactams and 1-acylazetidines derived from phenylalanine.

E. De Clercq, M. García-López, R. González-Muñiz, 2004, Bioorganic & medicinal chemistry letters.

Synthesis and SAR studies on azetidine-containing dipeptides as HCMV inhibitors

M. García-López, R. González-Muñiz, J. Balzarini, 2010, Bioorganic & Medicinal Chemistry.

4-Benzyloxy-gamma-sultone derivatives: discovery of a novel family of non-nucleoside inhibitors of human cytomegalovirus and varicella zoster virus.

J. Balzarini, S. de Castro, M. Camarasa, 2009, Journal of medicinal chemistry.

From 1-acyl-beta-lactam human cytomegalovirus protease inhibitors to 1-benzyloxycarbonylazetidines with improved antiviral activity. A straightforward approach to convert covalent to noncovalent inhibitors.

E. De Clercq, M. García-López, R. González-Muñiz, 2005, Journal of medicinal chemistry.

Novel water-soluble prodrugs of acyclovir cleavable by the dipeptidyl-peptidase IV (DPP IV/CD26) enzyme.

I. De Meester, G. Mulder, J. Balzarini, 2013, European journal of medicinal chemistry.

Intracellular trapping of cycloSal-pronucleotides: modification of prodrugs with amino acid esters.

J. Balzarini, C. Meier, H. Jessen, 2008, Journal of medicinal chemistry.

Synthesis and biological evaluation of 3,3-difluoropyridine-2,4(1H,3H)-dione and 3-deaza-3-fluorouracil base and nucleoside derivatives.

E. De Clercq, J. Balzarini, M. Robins, 2009, Journal of medicinal chemistry.

Comparative cytostatic activity of different antiherpetic drugs against herpes simplex virus thymidine kinase gene-transfected tumor cells.

R. T. Walker, E. De Clercq, J. Balzarini, 1994, Molecular pharmacology.

Synthesis and antiviral activity of highly water-soluble polycarboxylic derivatives of [70]fullerene.

P. Troshin, J. Balzarini, A. Peregudov, 2011, Chemical communications.

New prodrugs of two pyrimidine acyclic nucleoside phosphonates: Synthesis and antiviral activity

J. Balzarini, G. Andrei, M. Dračínský, 2017, Bioorganic & Medicinal Chemistry.

An efficient microwave-assisted synthesis and biological properties of polysubstituted pyrimidinyl- and 1,3,5-triazinylphosphonic acids

J. Balzarini, P. Jansa, M. Dračínský, 2011, Tetrahedron.

Synthesis and antiviral activity of N9-[3-fluoro-2-(phosphonomethoxy)propyl] analogues derived from N6-substituted adenines and 2,6-diaminopurines.

E. De Clercq, J. Balzarini, P. Jansa, 2011, Bioorganic & medicinal chemistry.

Dipeptidyl peptidase IV dependent water-soluble prodrugs of highly lipophilic bicyclic nucleoside analogues.

I. De Meester, J. Balzarini, M. Camarasa, 2011, Journal of medicinal chemistry.

Improvement of purine and pyrimidine antimetabolite-based anticancer treatment by selective suppression of mycoplasma-encoded catabolic enzymes.

J. Balzarini, A. Bronckaers, S. Liekens, 2009, The Lancet. Oncology.

Synthesis and Biological Evaluation of Some Acyclic Pyridine C-Nucleosides. Part Two

J. Balzarini, E. Clercq, R. Dommisse, 1994 .

AIDS dementia: Synthesis and properties of a derivative of 3′‐azido‐3′‐deoxythymidine (AZT) that may become ‘locked’ in the central nervous system

E. De Clercq, J. Balzarini, P. Torrence, 1988, FEBS letters.

Immunomodulatory activity of 9-(2-phosphonylmethoxyethyl)adenine (PMEA), a potent anti-HIV nucleotide analogue, on in vivo murine models.

E. De Clercq, A. Foli, C. Perno, 1991, Antiviral research.

Synthesis and biological activity of a novel water-soluble methano[60]fullerene tetracarboxylic derivative

G. V. Guseva, P. Troshin, J. Balzarini, 2013 .

Use of Cyclohexene Epoxides in the Preparation of Carbocyclic Nucleosides

P. Herdewijn, J. Rozenski, J. Balzarini, 1996 .

Molecular structures and ab initio molecular orbital calculations of the optically active derivatives of 1-aminocyclopropane-1-carboxylic acid

G. Folkers, L. Scapozza, K. Pavelić, 2003 .

The Thymidine Phosphorylase Inhibitor 5′-O-Tritylinosine (KIN59) Is an Antiangiogenic Multitarget Fibroblast Growth Factor-2 Antagonist

D. Ribatti, B. Nico, G. Opdenakker, 2012, Molecular Cancer Therapeutics.

Antiviral, antimetabolic, and cytotoxic activities of 5-substituted 2'-deoxycytidines.

R. T. Walker, E. De Clercq, J. Balzarini, 1982, Molecular Pharmacology.

Thymidylate synthetase as target enzyme for the inhibitory activity of 5-substituted 2'-deoxyuridines on mouse leukemia L1210 cell growth.

R. T. Walker, E. De Clercq, P. Barr, 1981, Molecular pharmacology.

HPMPC (cidofovir), PMEA (adefovir) and Related Acyclic Nucleoside Phosphonate Analogues: A Review of their Pharmacology and Clinical Potential in the Treatment of Viral Infections

E. De Clercq, L. Naesens, J. Neyts, 1997 .

Pyridine N-oxide derivatives inhibit viral transactivation by interfering with NF-kappaB binding.

E. De Clercq, C. Pannecouque, J. Balzarini, 2006, Biochemical pharmacology.

Anticancer activity of novel hybrid molecules containing 5-benzylidene thiazolidine-2,4-dione.

María Kimatrai Salvador, J. Balzarini, P. Baraldi, 2013, European journal of medicinal chemistry.

Ingold's Nitration Mechanism Lives!

F. Radner, U. Ragnarsson, J. Balzarini, 1994 .

Anti-human immunodeficiency virus effects of cationic metalloporphyrin-ellipticine complexes.

E. De Clercq, J. Balzarini, D. Schols, 1992, Biochemical pharmacology.

Alpha-(1-3)- and alpha-(1-6)-D-mannose-specific plant lectins are markedly inhibitory to human immunodeficiency virus and cytomegalovirus infections in vitro

E. De Clercq, J. Neyts, J. Balzarini, 1991, Antimicrobial Agents and Chemotherapy.

Marked in vivo antiretrovirus activity of 9-(2-phosphonylmethoxyethyl)adenine, a selective anti-human immunodeficiency virus agent.

E. De Clercq, R. Pauwels, L. Naesens, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Tetra-end-linked oligonucleotides forming DNA G-quadruplexes: a new class of aptamers showing anti-HIV activity.

G. Piccialli, S. Haider, J. Balzarini, 2010, Chemical communications.

How a Modification (8‐Aza‐3‐deaza‐2′‐deoxyguanosine) Influences the Quadruplex Structure of Hotoda's 6‐Mer TGGGAG with 5′‐ and 3′‐End Modifications

E. De Clercq, C. Pannecouque, J. Balzarini, 2004, Nucleosides, Nucleotides & Nucleic Acids.

N1-substituted thymine derivatives as mitochondrial thymidine kinase (TK-2) inhibitors.

F. Gago, J. Balzarini, A. Karlsson, 2006, Journal of medicinal chemistry.

Anti-retroviral and cytostatic activity of 2',3'-dideoxyribonucleoside 3'-disulfides.

J. Balzarini, J. Décout, J. Désiré, 2008, Bioorganic & medicinal chemistry.

Synthesis, biophysical characterization, and anti-HIV activity of glyco-conjugated G-quadruplex-forming oligonucleotides.

J. Balzarini, C. Giancola, L. Martino, 2008, Bioconjugate chemistry.

Phosphoramidate derivatives of d4T as inhibitors of HIV: the effect of amino acid variation.

E. De Clercq, L. Naesens, J. Balzarini, 1997, Antiviral research.

Intracellular delivery of bioactive AZT nucleotides by aryl phosphate derivatives of AZT.

E. De Clercq, J. Balzarini, C. Mcguigan, 1993, Journal of medicinal chemistry.

Long-Lasting Enfuvirtide Carrier Pentasaccharide Conjugates with Potent Anti-Human Immunodeﬁciency Virus Type 1 Activity (cid:1)

L. Vincent, J. Balzarini, D. Schols, 2009 .

Modes of action of interferon and analogues of 2-5A, a mediator of interferon action

H. Sawai, J. Balzarini, E. Clercq, 1984 .

The rare HIV-1 gp41 mutations 43T and 50V elevate enfuvirtide resistance levels of common enfuvirtide resistance mutations that did not impact susceptibility to sifuvirtide.

A. Vandamme, K. Van Laethem, J. Balzarini, 2010, Antiviral research.

Design, synthesis and biological evaluation of 3,5-disubstituted 2-amino thiophene derivatives as a novel class of antitumor agents.

María Kimatrai Salvador, A. Brancale, G. Basso, 2014, Bioorganic & medicinal chemistry.

Concise synthesis and biological evaluation of 2-Aroyl-5-amino benzo[b]thiophene derivatives as a novel class of potent antimitotic agents.

A. Brancale, G. Basso, Su-zhan Zhang, 2013, Journal of medicinal chemistry.

One-pot synthesis and biological evaluation of 2-pyrrolidinyl-4-amino-5-(3',4',5'-trimethoxybenzoyl)thiazole: a unique, highly active antimicrotubule agent.

A. Brancale, G. Basso, Su-zhan Zhang, 2011, European journal of medicinal chemistry.

Symmetrical alpha-bromoacryloylamido diaryldienone derivatives as a novel series of antiproliferative agents. Design, synthesis and biological evaluation.

G. Basso, G. Viola, Roberta Bortolozzi, 2010, Bioorganic & medicinal chemistry letters.

Hybrid alpha-bromoacryloylamido chalcones. Design, synthesis and biological evaluation.

R. Gambari, E. Fabbri, G. Basso, 2009, Bioorganic & medicinal chemistry letters.

Enantiocontrolled Preparation of ϒ-Substituted Cyclohexenones: Synthesis and Kinase Activity Assays of Cyclopropyl-Fused Cyclohexane Nucleosides

J. Balzarini, O. Illa, F. Busqué, 2022, International journal of molecular sciences.

Design, synthesis and bioevaluation of novel candidate selective estrogen receptor modulators.

V. S. Parmar, A. Jha, C. K. Too, 2011, European journal of medicinal chemistry.

The Cellular Thioredoxin-1/Thioredoxin Reductase-1 Driven Oxidoreduction Represents a Chemotherapeutic Target for HIV-1 Entry Inhibition

C. Pannecouque, J. Balzarini, A. Karlsson, 2016, PloS one.

The Grifﬁthsin Dimer Is Required for High-Potency Inhibition of HIV-1: Evidence for Manipulation of the Structure of gp120 as Part of the Grifﬁthsin Dimer Mechanism

J. Balzarini, Ioannis Kagiampakis, B. Hoorelbeke, 2013 .

Glycine-Amide Is an Active Metabolite of the Antiretroviral Tripeptide Glycyl-Prolyl-Glycine-Amide

S. Höglund, E. Andersson, J. Balzarini, 2005, Antimicrobial Agents and Chemotherapy.

An Approach towards the Synthesis of Potential Metal-Chelating TSAO-T Derivatives as Bidentate Inhibitors of Human Immunodeficiency virus Type 1 Reverse Transcriptase

E. De Clercq, J. Balzarini, M. Camarasa, 1998, Antiviral chemistry & chemotherapy.

Conformational States of HIV-1 Reverse Transcriptase for Nucleotide Incorporation vs Pyrophosphorolysis-Binding of Foscarnet.

E. Arnold, J. DeStefano, K. Das, 2016, ACS chemical biology.

The Role of Thr139 in the Human Immunodeficiency Virus Type 1 Reverse Transcriptase Sensitivity to (+)-Calanolide A

E. De Clercq, F. Ceccherini‐Silberstein, F. Gago, 2005, Molecular Pharmacology.

Synthesis and anti-HIV activity of 1,1,3-trioxo-2H,4H-thieno[3,4-e][1,2,4]thiadiazines (TTDs): a new family of HIV-1 specific non-nucleoside reverse transcriptase inhibitors.

E. De Clercq, J. Balzarini, M. Witvrouw, 1999, Bioorganic & medicinal chemistry.

Synthesis and Antiviral Activities of 1,2,3-triazole Functionalized Thymidines: 1,3-dipolar Cycloaddition for Efficient Regioselective Diversity Generation

E. De Clercq, J. Balzarini, Michael R. Korn, 2005, Antiviral chemistry & chemotherapy.

Anticonvulsant phenytoinergic pharmacophores and anti-HIV activity--preliminary evidence for the dual requirement of the 4-aminophthalimide platform and the N-(1-adamantyl) substitution for antiviral properties.

E. De Clercq, J. Poupaert, J. Balzarini, 1998, Life sciences.

FV100 as a new approach for the possible treatment of varicella-zoster virus infection.

J. Balzarini, C. Mcguigan, 2009, The Journal of antimicrobial chemotherapy.

Multivalent agents containing 1-substituted 2,3,4-trihydroxyphenyl moieties as novel synthetic polyphenols directed against HIV-1.

J. Balzarini, M. Camarasa, E. Quesada, 2014, Organic & biomolecular chemistry.

Novel (E)-5-(2-iodovinyl)-2'-deoxyuridine derivatives as potential cytostatic agents against herpes simplex virus thymidine kinase gene transfected tumors.

E. De Clercq, J. Balzarini, L. Wiebe, 1995, Gene Therapy.

Carbohydrate-Binding Non-Peptidic Pradimicins for the Treatment of Acute Sleeping Sickness in Murine Models

J. Balzarini, S. Liekens, Y. Igarashi, 2016, PLoS pathogens.

Synthesis and Antiviral Evaluation of 3′-Substituted Thymidine Analogues Derived from 3′-Amino-3′-deoxythymidine

C. Pannecouque, P. Herdewijn, J. Balzarini, 1995 .

[2',5'-Bis-O-(tert-butyldimethylsilyl)]-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide) (TSAO) derivatives of purine and pyrimidinenucleosides as potent and selective inhibitors of human immunodeficiency virus type 1

E. De Clercq, J. Balzarini, M. Camarasa, 1992, Antimicrobial Agents and Chemotherapy.

,5 '-Bis-O-(tert-Butyldimethylsilyl)]-3' -Spiro-5"-(4"-Amino-1",2"-Oxathiole-2",2"-Dioxide) (TSAO) Derivatives of Purine and Pyrimidine Nucleosides as Potent and Selective Inhibitors of Human Immunodeficiency Virus Type 1

J. Balzarini, M. Camarasa, S. Velázquez, 2022 .

A new class of dual-targeted antivirals: monophosphorylated acyclovir prodrug derivatives suppress both human immunodeficiency virus type 1 and herpes simplex virus type 2.

R. Schinazi, J. Grivel, L. Margolis, 2010, The Journal of infectious diseases.

The cytostatic activity of NUC-3073, a phosphoramidate prodrug of 5-fluoro-2'-deoxyuridine, is independent of activation by thymidine kinase and insensitive to degradation by phosphorolytic enzymes.

J. Balzarini, S. Liekens, C. Mcguigan, 2011, Biochemical pharmacology.

Antiviral activity of selected nucleoside analogues against human herpes virus type 6

L. Naesens, J. Balzarini, E. Clercq, 1995 .

Synthesis and anti-HCMV activity of 1-[ω-(phenoxy)alkyl]uracil derivatives and analogues thereof

J. Balzarini, G. Andrei, R. Snoeck, 2013, Bioorganic & Medicinal Chemistry.

Dipeptidyl Peptidase IV (DPPIV/CD26)‐Based Prodrugs of Hydroxy‐Containing Drugs

A. Lambeir, J. Balzarini, M. Camarasa, 2012, ChemMedChem.

Inhibition of Cell-to-Cell Transmission of Human T-Cell Lymphotropic Virus Type 1 In Vitro by Carbohydrate-Binding Agents

J. Balzarini, Y. Igarashi, T. Oki, 2008, Antimicrobial Agents and Chemotherapy.

Diaryl phosphate derivatives act as pro-drugs of AZT with reduced cytotoxicity compared to the parent nucleoside

J. Balzarini, E. Clercq, C. Mcguigan, 1994 .

Efficacy of oral 9‐(2‐phosphonylmethoxyethyl)‐2,6‐diaminopurine (PMEDAP) in the treatment of retrovirus and cytomegalovirus infections in mice

E. De Clercq, L. Naesens, J. Neyts, 1993, Journal of medical virology.

Inhibition of HIV Replication and Enhancement of Immune Functions by the Acyclic Nucleoside Phosphonate 9-(2-Phosphonyl-Methoxyethyl)Adenine (PMEA)

C. Perno, J. Balzarini, S. Aquaro, 1993 .

Synthesis of {1-[2′,5′-Bis-O-(t-butyldimethylsilyl)-β-d-xylo- and β-d-ribofuranosyl]thymine}-3′-spiro-5″-{4″-amino-1″,2″-oxathiole-2″,2″-dioxide} (TSAO). A novel type of specific anti-HIV agents

J. Balzarini, M. Pérez-Pérez, A. San-Félix, 1992 .

Different pattern of activity of inhibitors of the human immunodeficiency virus in lymphocytes and monocyte/macrophages.

A. Bergamini, E. De Clercq, R. Pauwels, 1992, Antiviral research.

Synthesis and Antiviral Activity of 6-Benzoyl-Benzoxazolin-2-One and 6-Benzoyl-Benzothiazolin-2-One Derivatives

E. De Clercq, J. Poupaert, J. Balzarini, 1999, Antiviral chemistry & chemotherapy.

Phenylboronic-Acid-Based Carbohydrate Binders as Antiviral Therapeutics: Monophenylboronic Acids

J. Balzarini, C. Mcguigan, P. Trippier, 2010, Antiviral chemistry & chemotherapy.

A general approach for the non-stop solid phase synthesis of TAC-scaffolded loops towards protein mimics containing discontinuous epitopes.

R. Liskamp, J. Kruijtzer, J. Balzarini, 2009, Chemical communications.

Antiviral activity of selected acyclic nucleoside analogues against human herpesvirus 6.

E. De Clercq, L. Naesens, J. Balzarini, 1995, Antiviral research.

Characterization of Herpes Simplex Virus Type 1 Thymidine Kinase Mutants Selected under a Single Round of High-Dose Brivudin

E. De Clercq, G. Opdenakker, J. Balzarini, 2005, Journal of Virology.

The first series of 4,11-bis[(2-aminoethyl)amino]anthra[2,3-b]furan-5,10-diones: Synthesis and anti-proliferative characteristics.

M. Preobrazhenskaya, J. Balzarini, A. Shtil, 2011, European journal of medicinal chemistry.

Synthesis and cytotoxic properties of 4,11-bis[(aminoethyl)amino]anthra[2,3-b]thiophene-5,10-diones, novel analogues of antitumor anthracene-9,10-diones.

M. Preobrazhenskaya, J. Balzarini, A. Shtil, 2009, Bioorganic & medicinal chemistry.

Sulfated polymers inhibit the interaction of human cytomegalovirus with cell surface heparan sulfate.

A. Van Schepdael, E. De Clercq, J. Esko, 1992, Virology.

Synthesis of 3-fluoro-6-S-(2-S-pyridyl) nucleosides as potential lead cytostatic agents

J. Balzarini, S. Manta, D. Komiotis, 2010, Bioorganic Chemistry.

Inhibitory effects of potent inhibitors of human immunodeficiency virus and cytomegalovirus on the growth of human granulocyte-macrophage progenitor cells in vitro

J. Balzarini, E. Clercq, R. Snoeck, 1990, European Journal of Clinical Microbiology and Infectious Diseases.

Nebrodeolysin, a novel hemolytic protein from mushroom Pleurotus nebrodensis with apoptosis-inducing and anti-HIV-1 effects.

J. Bao, J. Balzarini, E. V. Van Damme, 2009, Phytomedicine : international journal of phytotherapy and phytopharmacology.

Synthesis of a New Series of Phosphonylated 1,2,3‐Triazoles as Acyclic Analogs of Ribavirin

J. Balzarini, A. Wróblewski, I. Głowacka, 2013, Archiv der Pharmazie.

Anti-HIV-1 activity of antiviral compounds, as quantitated by a focal immunoassay in CD4+ HeLa cells and a plaque assay in MT-4 cells.

E. De Clercq, R. Pauwels, J. Balzarini, 1990, Journal of virological methods.

Anti‐angiogenic activity of a novel multi‐substrate analogue inhibitor of thymidine phosphorylase

E. De Clercq, J. Balzarini, S. Liekens, 2002, FEBS letters.

Obligatory involvement of CD26/dipeptidyl peptidase IV in the activation of the antiretroviral tripeptide glycylprolylglycinamide (GPG-NH(2)).

P. Proost, E. Andersson, J. Van Damme, 2004, The international journal of biochemistry & cell biology.

Phosphoramidate ProTides of the anticancer agent FUDR successfully deliver the preformed bioactive monophosphate in cells and confer advantage over the parent nucleoside.

J. Balzarini, S. Liekens, C. Mcguigan, 2011, Journal of medicinal chemistry.

Strategies for the measurement of the inhibitory effects of thymidine analogs on the activity of thymidylate synthase in intact murine leukemia L1210 cells.

E. De Clercq, J. Balzarini, 1984, Biochimica et biophysica acta.

Organometallic nucleoside analogues with ferrocenyl linker groups: synthesis and cancer cell line studies.

J. Balzarini, Y. Mehellou, J. H. Tucker, 2014, Journal of medicinal chemistry.

Differential in vitro inhibitory activity against HIV-1 of alpha-(1-3)- and alpha-(1-6)-D-mannose specific plant lectins : Implication for microbicide development

M. Lecerf, J. Balzarini, D. Schols, 2007, Journal of Translational Medicine.

Synthesis of a difluoromethylenephosphonate analogue of AZT 5'-triphosphate and its inhibition of HIV-1 reverse transcriptase

J. Balzarini, E. Clercq, K. Kirk, 1991 .

R. Borchardt, J. Balzarini, E. Clercq, 2001 .

Anticancer and antiviral effects and inactivation of S-adenosyl-L-homocysteine hydrolase with 5'-carboxaldehydes and oximes synthesized from adenosine and sugar-modified analogues.

E. De Clercq, R. Borchardt, J. Balzarini, 1997, Journal of medicinal chemistry.

E. De Clercq, R. Borchardt, J. Balzarini, 1994, Journal of medicinal chemistry.

Nucleoside Mono‐ and Diphosphate Prodrugs of 2′,3′‐Dideoxyuridine and 2′,3′‐Dideoxy‐2′,3′‐didehydrouridine

J. Balzarini, C. Meier, F. Pertenbreiter, 2015, ChemMedChem.

Doubly loaded cycloSaligenyl-pronucleotides - 5,5'-Bis-(cycloSaligenyl-2',3'-dideoxy-2',3'-didehydrothymidine monophosphates).

J. Balzarini, N. Gisch, C. Meier, 2009, Journal of medicinal chemistry.

cycloSal-Pronucleotides of 2'-fluoro-ara- and 2'-fluoro-ribo-2',3'- dideoxyadenosine as a strategy to bypass a metabolic blockade.

E. De Clercq, J. Balzarini, V. Marquez, 1999, Journal of medicinal chemistry.

Nucleotide Delivery from cycloSaligenyl‐3′‐azido‐3′‐deoxythymidine Monophosphates (cycloSal‐AZTMP)

J. Balzarini, E. D. Clercq, C. Meier, 1998 .

cycloSal-2',3'-dideoxy-2',3'-didehydrothymidine monophosphate (cycloSal-d4TMP): synthesis and antiviral evaluation of a new d4TMP delivery system.

E. De Clercq, J. Balzarini, M. Lorey, 1998, Journal of medicinal chemistry.

Broad-spectrum antiviral activities of neplanocin A, 3-deazaneplanocin A, and their 5'-nor derivatives

E. De Clercq, R. Borchardt, J. Balzarini, 1989, Antimicrobial Agents and Chemotherapy.

Pronounced cytostatic activity and bystander effect of a novel series of fluorescent tricyclic acyclovir and ganciclovir derivatives in herpes simplex virus thymidine kinase gene-transduced tumor cell lines

J. Balzarini, E. Clercq, T. Goslinski, 2002, Gene Therapy.

Selection of HSV-1 TK gene-transfected murine mammary carcinoma cells resistant to (E)-5-(2-bromovinyl)-2′-deoxyuridine (BVDU) and ganciclovir (GCV)

B. Degrève, J. Balzarini, E. D. Clercq, 2000, Gene Therapy.

Budding yeast as a screening tool for discovery of nucleoside analogs for use in HSV-1 TK suicide-gene therapy.

J. Thevelein, E. De Clercq, J. Neyts, 1999, BioTechniques.

Exploring the role of the 5'-position of TSAO-T. Synthesis and anti-HIV evaluation of novel TSAO-T derivatives.

E. De Clercq, F. Gago, J. Balzarini, 2001, Antiviral research.

Synthesis and Biological Evaluation of Purine 2′‐Fluoro‐2′‐deoxyriboside ProTides as Anti‐influenza Virus Agents

L. Naesens, A. Brancale, J. Balzarini, 2013, ChemMedChem.

Synthesis and antiviral activity evaluation of some new aminoadamantane derivatives. 2.

E. De Clercq, J. Neyts, J. Balzarini, 1996, Journal of medicinal chemistry.

Aryloxy phosphoramidate triesters as pro-tides.

J. Balzarini, C. Mcguigan, D. Cahard, 2004, Mini reviews in medicinal chemistry.

Cellular uptake of phosphonylmethoxyalkylpurine derivatives.

E. De Clercq, G. Palù, J. Balzarini, 1991, Antiviral research.

Structure‐activity relationship studies on a Trp dendrimer with dual activities against HIV and enterovirus A71. Modifications on the amino acid

J. Neyts, J. Balzarini, D. Schols, 2017, Antiviral research.

Synthesis of the 5′‐Fluoro‐2′β‐methyl Analogues of Neplanocin

J. Balzarini, H. Kumamoto, Hiromichi Tanaka, 2011 .

Selective inhibition of human inmunodeficiency virus type 1 ( HIV-1 ) by nucleoside analogues with an unusual tricyclic structure

J. Balzarini, M. Camarasa, E. Quesada, 2014 .

Selective inhibition of Human Immunodeficiency Virus type 1 (HIV-1) by a novel family of tricyclic nucleosides.

E. Vanstreels, J. Balzarini, M. Camarasa, 2011, Antiviral research.

Alpha-carboxynucleoside phosphonates: direct-acting inhibitors of viral DNA polymerases.

E. Arnold, W. Dehaen, K. Das, 2019, Future medicinal chemistry.

Enantioselective syntheses of carbocyclic nucleosides 5′-homocarbovir, epi-4′-homocarbovir, and their cyclopropylamine analogs using facially selective Pd-mediated allylations

J. Balzarini, Marvin J Miller, Lawrence P. Tardibono, 2010, Tetrahedron.

Syntheses and anti-HIV activities of (+/-)-norcarbovir and (+/-)-norabacavir.

E. De Clercq, J. Balzarini, Weiqiang Huang, 2007, Organic & biomolecular chemistry.

Improved antiviral activity of the aryloxymethoxyalaninyl phosphoramidate (APA) prodrug of abacavir (ABC) is due to the formation of markedly increased carbovir 5′‐triphosphate metabolite levels

J. Balzarini, C. Mcguigan, S. Aquaro, 2004, FEBS letters.

Carbocyclic analogues of nucleosides from bis-(Hydroxymethyl)-cyclopentane: synthesis, antiviral and cytostatic activities of adenosine, inosine and uridine analogues.

E. De Clercq, O. Caamaño, J. Balzarini, 2003, Chemical & pharmaceutical bulletin.

SYNTHESIS, ANTIVIRAL AND CYTOSTATIC ACTIVITIES, OF CARBOCYCLIC NUCLEOSIDES INCORPORATING A MODIFIED CYCLOPENTANE RING. IV. ADENOSINE AND URIDINE ANALOGUES

E. De Clercq, J. Balzarini, F. Fernández, 2002, Nucleosides, nucleotides & nucleic acids.

Synthesis and antiviral activity of carbocyclic nucleosides incorporating a modified cyclopentane ring. Part 3: Adenosine and uridine analogues.

E. De Clercq, X. García‐Mera, J. Balzarini, 1999, Nucleosides & nucleotides.

SIV/HIV-1 hybrid virus expressing the reverse transcriptase gene of HIV-1 remains sensitive to HIV-1-specific reverse transcriptase inhibitors after passage in rhesus macaques.

E. De Clercq, K. Überla, K. Uberla, 1997, Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association.

Norbornane-based nucleoside and nucleotide analogues locked in North conformation.

L. Naesens, E. Bouřa, J. Neyts, 2015, Bioorganic & medicinal chemistry.

Prodrugs of γ‐Alkyl‐Modified Nucleoside Triphosphates: Improved Inhibition of HIV Reverse Transcriptase

J. Balzarini, D. Schols, C. Meier, 2020, Angewandte Chemie.

Synthesis, antimycobacterial, antiviral, antimicrobial activities, and QSAR studies of nicotinic acid benzylidene hydrazide derivatives

B. Narasimhan, P. Yogeeswari, D. Sriram, 2012, Medicinal Chemistry Research.

Efficacy of (S)‐1‐(3‐hydroxy‐2‐phosphonylmethoxypropyl)cytosine and 9‐(1,3‐dihydroxy‐2‐propoxymethyl)guanine for the treatment of murine cytomegalovirus infection in severe combined immunodeficiency mice

E. De Clercq, L. Naesens, J. Neyts, 1992, Journal of medical virology.

Activity of different antiviral drug combinations against human cytomegalovirus replication in vitro

J. Balzarini, E. Clercq, D. Schols, 1992, European Journal of Clinical Microbiology and Infectious Diseases.

Effect of antimetabolite drugs of nucleotide metabolism on the anti-human immunodeficiency virus activity of nucleoside reverse transcriptase inhibitors.

J. Balzarini, 2000, Pharmacology & therapeutics.

The Thiocarboxanilides UC-10 and UC-781 Have an Additive Inhibitory Effect against Human Immunodeficiency Virus Type 1 Reverse Transcriptase and Replication in Cell Culture When Combined with other Antiretroviral Drugs

E. De Clercq, J. Balzarini, 1997 .

The Intracellular Formation of a Mononucleotide of the Anti-Influenza Agent 1,3,4-thiadiazol-2-ylcyanamide (LY217896)

J. Balzarini, J. Colacino, W. Ehlhardt, 1995 .

1-β-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide (ribavirin) and 5-ethynyl-1-β-D-ribofuranosylimidazole-4-carboxamide (EICAR) markedly potentiate the inhibitory effect of 2′,3′-dideoxyinosine on human immunodeficiency virus in peripheral blood lymphocytes

J. Balzarini, E. Clercq, D. Schols, 1991 .

Antiviral activities of 5-ethynyl-1-beta-D-ribofuranosylimidazole-4- carboxamide and related compounds

E. De Clercq, N. Minakawa, A. Matsuda, 1991, Antimicrobial Agents and Chemotherapy.

Initial studies on the cellular pharmacology of 2',3-dideoxycytidine, an inhibitor of HTLV-III infectivity.

H. Mitsuya, S. Broder, J. Mcmahon, 1986, Biochemical pharmacology.

Antiviral and Cytostatic Evaluation of the Novel 6-acyclic Chain Substituted Thymine Derivatives

E. De Clercq, K. Pavelić, J. Plavec, 2005, Antiviral Chemistry & Chemotherapy.

Synthesis and Antiviral Evaluation of Some 3′‐Fluoro Bicyclic Nucleoside Analogues

E. De Clercq, J. Balzarini, C. Mcguigan, 2004, Nucleosides, nucleotides & nucleic acids.

Bicyclic nucleoside inhibitors of Varicella-Zoster Virus (VZV): the effect of a terminal halogen substitution in the side-chain.

E. De Clercq, A. Brancale, J. Balzarini, 2000, Bioorganic & medicinal chemistry letters.

Cytotoxic 5-aryl-1-(4-nitrophenyl)-3-oxo-1,4-pentadienes mounted on alicyclic scaffolds.

E. De Clercq, J. Dimmock, Rajendra K. Sharma, 2006, European journal of medicinal chemistry.

Synthesis and Antiviral Evaluation of Carbocyclic 3′‐Azidothymidine (AZT) Analogues and Their cycloSal‐Phosphate Triesters

J. Balzarini, C. Meier, O. Ludek, 2006 .

Long-term exposure of HIV type 1-infected cell cultures to combinations of the novel quinoxaline GW420867X with lamivudine, abacavir, and a variety of nonnucleoside reverse transcriptase inhibitors.

E. De Clercq, J. Balzarini, E. Clercq, 2000, AIDS research and human retroviruses.

Evaluation of Compounds Against Recombinant HIV Reverse Transcriptase.

J. Balzarini, 2000, Methods in molecular medicine.

Synthesis and anti-HIV Evaluation of Alkyl and Alkoxyethyl Phosphodiester AZT Derivatives

E. De Clercq, A. Tsotinis, J. Balzarini, 1995 .

Synthesis of 2',3'-dideoxy-3-isoadenosine : a new structural analogue of the anti-HIV active compound, 2,3'-dideoxyadenosine

J. Balzarini, E. Clercq, N. Leonard, 1991 .

Synthesis and Biological Evaluation of 2-(2-deoxy-d-erythro-pent-1-enofuranosyl)pyridine C-nucleosides

J. Balzarini, E. Clercq, R. Dommisse, 1991 .

The antiretroviral and cytostatic activity, and metabolism of 3'-azido-2',3'-dideoxythymidine, 3'-fluoro-2',3'-dideoxythymidine and 2',3'-dideoxycytidine are highly cell type-dependent.

E. De Clercq, J. Balzarini, P. Meeus, 1989, Advances in experimental medicine and biology.

9-(2-phosphonylmethoxyethyl)-N6-cyclopropyl-2,6-diaminopurine: a novel prodrug of 9-(2-phosphonylmethoxyethyl)guanine with improved antitumor efficacy and selectivity in choriocarcinoma-bearing rats.

E. De Clercq, L. Naesens, J. Balzarini, 1999, Oncology research.

Acute cytotoxicity of arabinofuranosyl nucleoside analogs is not dependent on mitochondrial DNA.

J. Balzarini, A. Karlsson, L. Lewis, 2009, Experimental cell research.

Increased mitochondrial DNA copy-number in CEM cells resistant to delayed toxicity of 2',3'-dideoxycytidine.

J. Balzarini, A. Karlsson, M. Bjerke, 2008, Biochemical pharmacology.

Activity of acyclic nucleoside phosphonate analogues against human immunodeficiency virus in monocyte/macrophages and peripheral blood lymphocytes.

E. De Clercq, C. Perno, J. Balzarini, 1991, Biochemical and biophysical research communications.

Antiretroviral activity and pharmacokinetics in mice of oral bis(pivaloyloxymethyl)-9-(2-phosphonylmethoxyethyl)adenine, the bis(pivaloyloxymethyl) ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine

E. De Clercq, L. Naesens, J. Balzarini, 1996, Antimicrobial agents and chemotherapy.

Synthesis of Purine and 7‐Deazapurine Nucleoside Analogues of 6‐N‐(4‐Nitrobenzyl)adenosine; Inhibition of Nucleoside Transport and Proliferation of Cancer Cells

S. Yao, J. Balzarini, S. Wnuk, 2014, ChemMedChem.

Antiviral activity of C-5 substituted tubercidin analogues.

E. De Clercq, J. Balzarini, D. Bergstrom, 1984, Journal of medicinal chemistry.

Synthesis and Anti-HIV Activity of some Novel Chain-Extended Phosphoramidate Derivatives of d4T (Stavudine): Esterase Hydrolysis as a Rapid Predictive Test for Antiviral Potency

E. De Clercq, J. Balzarini, C. Mcguigan, 1998, Antiviral chemistry & chemotherapy.

γ-Ketobenzyl-Modified Nucleoside Triphosphate Prodrugs as Potential Antivirals.

J. Balzarini, D. Schols, C. Meier, 2020, Journal of medicinal chemistry.

γ‐Non‐Symmetrically Dimasked TriPPPro Prodrugs as Potential Antiviral Agents against HIV

J. Balzarini, D. Schols, C. Meier, 2020, ChemMedChem.

Guanine &agr;‐carboxy nucleoside phosphonate (G‐&agr;‐CNP) shows a different inhibitory kinetic profile against the DNA polymerases of human immunodeficiency virus (HIV) and herpes viruses

E. Arnold, K. Das, P. Boehmer, 2017, Biochemical pharmacology.

Membrane-permeable Triphosphate Prodrugs of Nucleoside Analogues.

J. Balzarini, D. Schols, I. Hauber, 2016, Angewandte Chemie.

Design and synthesis of α-carboxy nucleoside phosphonate analogues and evaluation as HIV-1 reverse transcriptase-targeting agents.

A. Maguire, J. Balzarini, T. Legigan, 2015, The Journal of organic chemistry.

Discovery of a nanomolar inhibitor of lung adenocarcinoma in vitro.

J. Balzarini, J. Shelton, M. A. Peterson, 2014, Bioorganic & Medicinal Chemistry Letters.

From norbornane-based nucleotide analogs locked in South conformation to novel inhibitors of feline herpes virus.

J. Neyts, J. Balzarini, P. Leyssen, 2014, Bioorganic & medicinal chemistry.

Antiviral potential of “new” acyclic nucleoside phosphonates, the 6-[2-phosphonomethoxy)alkoxy]-2,4-diaminopyrimidines

C. Pannecouque, L. Naesens, J. Neyts, 2004 .

5-Substituted-2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]pyrimidines-acyclic nucleoside phosphonate analogues with antiviral activity.

E. De Clercq, J. Balzarini, G. Andrei, 2003, Journal of medicinal chemistry.

2',3'-Dideoxycytidine: regulation of its metabolism and anti-retroviral potency by natural pyrimidine nucleosides and by inhibitors of pyrimidine nucleotide synthesis.

S. Broder, J. Cupp, J. Balzarini, 1987, Molecular pharmacology.

Synthesis and anti-HIV activity of [AZT]-[TSAO-T] and [AZT]-[HEPT] dimers as potential multifunctional inhibitors of HIV-1 reverse transcriptase.

E. De Clercq, J. Balzarini, M. Camarasa, 1995, Journal of medicinal chemistry.

Synthesis, Anti-Human Immunodeficiency Virus Activity and Esterase Lability of Some Novel Carboxylic Ester-Modified Phosphoramidate Derivatives of Stavudine (d4T)

E. De Clercq, M. Gumbleton, J. Balzarini, 1998, Antiviral chemistry & chemotherapy.

Inhibitory effects of acyclic nucleoside phosphonates on human hepatitis B virus and duck hepatitis B virus infections in tissue culture

E. De Clercq, J. Balzarini, S. Schalm, 1994, Antimicrobial Agents and Chemotherapy.

Aryloxy Phosphoramidate Triesters: A Technology for Delivering Monophosphorylated Nucleosides and Sugars into Cells

J. Balzarini, C. Mcguigan, Y. Mehellou, 2010 .

Ester prodrugs of acyclic nucleoside thiophosphonates compared to phosphonates: synthesis, antiviral activity and decomposition study.

F. Zoulim, J. Balzarini, B. Canard, 2013, European journal of medicinal chemistry.

Synthesis and evaluation of novel amidate prodrugs of PMEA and PMPA.

E. De Clercq, J. Balzarini, E. Clercq, 2001, Bioorganic & medicinal chemistry letters.

Phosphoramidate Derivatives of Stavudine as Inhibitors of HIV: Unnatural Amino Acids May Substitute for Alanine

E. De Clercq, J. Balzarini, C. Mcguigan, 2000, Antiviral chemistry & chemotherapy.

cycloSal-Pronucleotides of 2',3'-dideoxyadenosine and 2', 3'-dideoxy-2',3'-didehydroadenosine: synthesis and antiviral evaluation of a highly efficient nucleotide delivery system.

E. De Clercq, J. Balzarini, C. Meier, 1999, Journal of medicinal chemistry.

Conversion of 2′,3′‐dideoxyadenosine (ddA) and 2′,3′‐didehydro‐2′,3′‐dideoxyadenosine (d4A) to their corresponding aryloxyphosphoramidate derivatives markedly potentiates their activity against human immunodeficiency virus and hepatitis B virus

E. De Clercq, C. Pannecouque, L. Naesens, 1997, FEBS letters.

Mechanism of anti-HIV action of masked alaninyl d4T-MP derivatives.

E. De Clercq, L. Naesens, C. Perno, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Aryl phosphoramidate derivatives of d4T have improved anti-HIV efficacy in tissue culture and may act by the generation of a novel intracellular metabolite.

E. De Clercq, J. Balzarini, E. Clercq, 1996, Journal of medicinal chemistry.

Synthesis and Antiviral Activity of Acyclic Nucleotide Analogues Derived from 6-(Aminomethyl)purines and Purine-6-carboxamidines

Michal Hocek, J. Balzarini, E. Clercq, 1996 .

Application of the cycloSal-prodrug approach for improving the biological potential of phosphorylated biomolecules.

J. Balzarini, C. Meier, 2006, Antiviral research.

Application of phosphoramidate pronucleotide technology to abacavir leads to a significant enhancement of antiviral potency.

E. De Clercq, T. Burnette, J. Balzarini, 2005, Journal of medicinal chemistry.

Inhibition of the in vitro growth of Plasmodium falciparum by acyclic nucleoside phosphonates.

E. De Clercq, L. Naesens, J. Balzarini, 1999, International journal of antimicrobial agents.

Antiviral activity of phosphonylmethoxyalkyl derivatives of purine and pyrimidines.

E. De Clercq, R. Pauwels, M. Baba, 1987, Antiviral research.

Antitumor potential of acyclic nucleoside phosphonates.

L. Naesens, J. Neyts, J. Balzarini, 1999, Nucleosides & nucleotides.

ProTides of BVdU as potential anticancer agents upon efficient intracellular delivery of their activated metabolites

A. Brancale, A. Westwell, J. Balzarini, 2016, Bioorganic & medicinal chemistry letters.

Application of ProTide technology to gemcitabine: a successful approach to overcome the key cancer resistance mechanisms leads to a new agent (NUC-1031) in clinical development.

M. Mason, J. Balzarini, C. Mcguigan, 2014, Journal of medicinal chemistry.

Synthesis and biological evaluation of pyrimidine nucleoside monophosphate prodrugs targeted against influenza virus.

L. Naesens, J. Balzarini, E. Vanderlinden, 2012, Antiviral research.

Phosphoramidates of 2′-β-d-arabinouridine (AraU) as phosphate prodrugs; design, synthesis, in vitro activity and metabolism

K. Mills, J. Balzarini, C. Mcguigan, 2010, Bioorganic & Medicinal Chemistry.

Enhanced 9-(2-phosphonylmethoxyethyl)adenine secretion by a specific, indomethacin-sensitive efflux pump in a mutant 9-(2-phosphonylmethoxyethyl)adenine-resistant human erythroleukemia K562 cell line.

E. De Clercq, J. Balzarini, S. Hatse, 1998, Molecular pharmacology.

Selection and characterisation of murine leukaemia L1210 cells with high-level resistance to the cytostatic activity of the acyclic nucleoside phosphonate 9-(2-phosphonylmethoxyethyl) adenine (PMEA).

E. De Clercq, L. Naesens, J. Balzarini, 1998, Biochimica et biophysica acta.

Differential antiherpesvirus and antiretrovirus effects of the (S) and (R) enantiomers of acyclic nucleoside phosphonates: potent and selective in vitro and in vivo antiretrovirus activities of (R)-9-(2-phosphonomethoxypropyl)-2,6-diaminopurine

E. De Clercq, L. Naesens, J. Balzarini, 1993, Antimicrobial Agents and Chemotherapy.

9-[(2RS)-3-fluoro-2-phosphonylmethoxypropyl] derivatives of purines: a class of highly selective antiretroviral agents in vitro and in vivo.

E. De Clercq, P. Herdewijn, J. Balzarini, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Synthesis and Evaluation of Prodrugs of α-Carboxy Nucleoside Phosphonates

A. Maguire, J. Balzarini, Nicholas D. Mullins, 2022, The Journal of organic chemistry.

6-[2-(Phosphonomethoxy)alkoxy]pyrimidines with antiviral activity.

E. De Clercq, L. Naesens, J. Balzarini, 2002, Journal of medicinal chemistry.

Structure-antiviral activity relationship in the series of pyrimidine and purine N-[2-(2-phosphonomethoxy)ethyl] nucleotide analogues. 1. Derivatives substituted at the carbon atoms of the base.

E. De Clercq, J. Balzarini, R. Snoeck, 1999, Journal of medicinal chemistry.

ANTIVIRAL POTENTIAL OF A NEW GENERATION OF ACYCLIC NUCLEOSIDE PHOSPHONATES, THE 6-[2-(PHOSPHONOMETHOXY)ALKOXY]-2,4-DIAMINOPYRIMIDINES

E. De Clercq, C. Pannecouque, L. Naesens, 2005, Nucleosides, nucleotides & nucleic acids.

Synthesis and antiviral activity of 2,4-diamino-5-cyano-6-[2-(phosphonomethoxy)ethoxy]pyrimidine and related compounds.

E. De Clercq, J. Balzarini, G. Andrei, 2004, Bioorganic & medicinal chemistry.

Activity of the (R)-enantiomers of 9-(2-phosphonylmethoxypropyl)-adenine and 9-(2-phosphonylmethoxypropyl)-2,6-diaminopurine against human immunodeficiency virus in different human cell systems.

E. De Clercq, C. Perno, J. Balzarini, 1996, Biochemical and biophysical research communications.

Synthesis, structure, and antitumor and antiviral activities of a series of 5-halouridine cyclic 3',5'-monophosphates.

E. De Clercq, J. Balzarini, L. Párkányi, 1986, Journal of medicinal chemistry.

Antiviral activity of the human immunodeficiency virus type 1-specific nonnucleoside reverse transcriptase inhibitor HBY 097 alone and in combination with zidovudine in a phase II study. HBY 097/2001 Study Group.

T. Merigan, M. Winters, J. Balzarini, 1999, The Journal of infectious diseases.

N6-cyclopropyl-PMEDAP: a novel derivative of 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP) with distinct metabolic, antiproliferative, and differentiation-inducing properties.

E. De Clercq, L. Naesens, J. Balzarini, 1999, Biochemical pharmacology.

Potent inhibition of human immunodeficiency virus and herpes simplex virus type 1 by 9-(2-phosphonylmethoxyethyl)adenine in primary macrophages is determined by drug metabolism, nucleotide pools, and cytokines.

C. Perno, J. Balzarini, S. Aquaro, 1996, Molecular pharmacology.

Kinetic Properties of Adenine Nucleotide Analogues Against Purified 5-Phosphoribosyl-1-pyrophosphate Synthetases from E. coli, Rat Liver and Human Erythrocytes

J. Balzarini, E. Clercq, M. Tatibana, 1995 .

Inhibitory Effects of Acyclic Nucleoside Phosphonate Analogues on Hepatitis B Virus DNA Synthesis in HB611 Cells

E. De Clercq, J. Balzarini, T. Yokota, 1994 .

Successful kinase bypass with new acyclovir phosphoramidate prodrugs.

J. Balzarini, J. Bugert, Marco Derudas, 2008, Bioorganic & medicinal chemistry letters.

Stereoselective synthesis and antiviral activity of methyl-substituted cycloSal-pronucleotides.

J. Balzarini, C. Meier, Edwuin H Rios Morales, 2012, Journal of medicinal chemistry.

Stereoselective Synthesis and Antiviral Activity of Methyl-Substituted cyclo Sal-Pronucleotides

J. Balzarini, C. Meier, E. H. Morales, 2012 .

Nucleoside diphosphate prodrugs.

J. Balzarini, C. Meier, H. Jessen, 2008, Nucleic acids symposium series.

Enzymatically activated cycloSal-d4T-monophosphates: The third generation of cycloSal-pronucleotides.

J. Balzarini, N. Gisch, C. Meier, 2007, Journal of medicinal chemistry.

cycloSal-PMEA and cycloAmb-PMEA: potentially new phosphonate prodrugs based on the cycloSal-pronucleotide approach.

J. Balzarini, C. Meier, C. Müller, 2005, Journal of medicinal chemistry.

“LOCK-IN” MODIFIED CYCLOSAL NUCLEOTIDES—THE SECOND GENERATION OF CYCLOSAL PRODRUGS

J. Balzarini, C. Meier, N. Böge, 2005, Nucleosides, nucleotides & nucleic acids.

Synthesis and antiretroviral evaluation of new alkoxy and aryloxy phosphate derivatives of 3'-azido-3'-deoxythymidine.

E. De Clercq, A. Tsotinis, J. Balzarini, 1996, Journal of medicinal chemistry.

Synthesis and antitumor and antiviral properties of 5-halo- and 5-(trifluoromethyl)-2'-deoxyuridine 3',5'-cyclic monophosphates and neutral triesters.

E. De Clercq, J. Balzarini, L. Otvös, 1986, Journal of medicinal chemistry.

Synthesis and antitumor and antiviral properties of 5-alkyl-2'-deoxyuridines, 3',5'-cyclic monophosphates, and neutral cyclic triesters.

E. De Clercq, J. Balzarini, L. Otvös, 1986, Journal of medicinal chemistry.

Synthesis and antiviral evaluation of α-L-2'-deoxythreofuranosyl nucleosides.

S. van Calenbergh, J. Balzarini, Marco Derudas, 2011, European journal of medicinal chemistry.

Synthesis, anti-HIV and cytostatic evaluation of 3'-deoxy-3'-fluorothymidine (FLT) pro-nucleotides.

A. Westwell, J. Balzarini, C. Mcguigan, 2014, Bioorganic & medicinal chemistry letters.

Synthesis and antiviral evaluation of some β-l-2′,3′-dideoxy-5-chloropyrimidine nucleosides and pronucleotides☆

E. De Clercq, P. Herdewijn, A. Aerschot, 2000 .

SYNTHESIS OF 1-(2-DEOXY-β-D-RIBOFURANOSYL)-2,4-DIFLUORO-5-SUBSTITUTED-BENZENES*: “THYMINE REPLACEMENT” ANALOGS OF THYMIDINE FOR EVALUATION AS ANTICANCER AND ANTIVIRAL AGENTS

E. De Clercq, J. Balzarini, L. Wiebe, 2001, Nucleosides, nucleotides & nucleic acids.

Highly Stereoselective Synthesis and Biological Properties of Nucleoside Analogues Bearing a Spiro Inserted Oxirane Ring

J. Tronchet, M. Seman, J. Balzarini, 2000, Nucleosides, nucleotides & nucleic acids.

Effect of 2-Amino Substitution on the Antiviral Effects of 5-Ethyl-2′-Deoxyuridine and (E)-5-(2-bromovinyl)-2′-Deoxyuridine and Their Incorporation into DNA

J. Balzarini, E. Clercq, K. Ebinger, 1991 .

Synthesis and Characterization of 4,11-Diaminoanthra[2,3-b]furan-5,10-diones: Tumor Cell Apoptosis through tNOX-Modulated NAD(+)/NADH Ratio and SIRT1.

M. Preobrazhenskaya, Yi-Hui Lee, P. Chueh, 2015, Journal of medicinal chemistry.

Synthesis and in vitro cytostatic activity of new β-d-arabino furan[1′,2′:4,5]oxazolo- and arabino-pyrimidinone derivatives

J. Balzarini, J. Leger, J. Bosc, 2009, European Journal of Medicinal Chemistry.

Dolutegravir Monotherapy of Simian Immunodeficiency Virus-Infected Macaques Selects for Several Patterns of Resistance Mutations with Variable Virological Outcomes

M. Wainberg, J. Lifson, B. Keele, 2018, Journal of Virology.

Cross-Metathesis Mediated Synthesis of New Acyclic Nucleoside Phosphonates

J. Neyts, J. Balzarini, S. Nolan, 2007, Nucleosides, nucleotides & nucleic acids.

Side-Chain Derivatives of Biologically Active Nucleosides. Part 2: Synthesis and anti-HIV Activity of 5′-C-Methyl Derivatives of 3′-Fluoro-3′-Deoxythymidine

E. De Clercq, J. Balzarini, E. Zbiral, 1996 .

Proﬁle of Resistance of Human Immunodeﬁciency Virus to Mannose-Speciﬁc Plant Lectins

A. Vandamme, J. Balzarini, E. Clercq, 2004 .

Synthesis of ester prodrugs of 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-2,6-diaminopurine (HPMPDAP) as anti-poxvirus agents.

E. De Clercq, L. Naesens, R. Pohl, 2010, Journal of medicinal chemistry.

A novel family of diarylpyrimidines (DAPYs) featuring a diatomic linker: Design, synthesis and anti-HIV activities.

E. De Clercq, C. Pannecouque, J. Balzarini, 2015, Bioorganic & medicinal chemistry.

RT Inhibitors as Microbicides

J. Balzarini, 2013 .

Synthesis and Anti‐HIV Activity of Aryl‐2‐[(4‐cyanophenyl)amino]‐4‐pyrimidinone hydrazones as Potent Non‐nucleoside Reverse Transcriptase Inhibitors

C. Pannecouque, Xiaodong Ma, J. Balzarini, 2011, ChemMedChem.

Design, synthesis and biological evaluation of cycloalkyl arylpyrimidines (CAPYs) as HIV-1 NNRTIs.

C. Pannecouque, Xiaodong Ma, J. Balzarini, 2011, Bioorganic & medicinal chemistry.

Lead Optimization of Diarylpyrimidines as Non‐nucleoside Inhibitors of HIV‐1 Reverse Transcriptase

C. Pannecouque, J. Balzarini, Fener Chen, 2010, ChemMedChem.

Structural Modifications of DAPY Analogues with Potent Anti‐HIV‐1 Activity

C. Pannecouque, J. Balzarini, Fener Chen, 2009, ChemMedChem.

Discovery of novel benzimidazolones as potent non-nucleoside reverse transcriptase inhibitors active against wild-type and mutant HIV-1 strains.

E. De Clercq, C. Pannecouque, G. Maga, 2007, Bioorganic & medicinal chemistry letters.

Inhibitory effect of 9-(2-phosphonylmethoxyethyl)adenine on visna virus infection in lambs: a model for in vivo testing of candidate anti-human immunodeficiency virus drugs.

E. De Clercq, L. Naesens, G. Georgsson, 1995, Proceedings of the National Academy of Sciences of the United States of America.

9-(2-Phosphonylmethoxyethyl)adenine in the treatment of murine acquired immunodeficiency disease and opportunistic herpes simplex virus infections

E. De Clercq, R. Cozens, H. Hochkeppel, 1989, Antimicrobial Agents and Chemotherapy.

Synthesis, antimicrobial and antiviral evaluation of substituted imidazole derivatives.

B. Narasimhan, E. De Clercq, J. Balzarini, 2009, European journal of medicinal chemistry.

2-(3-Aryl-2-propenoyl)-3-methylquinoxaline-1,4-dioxides: a novel cluster of tumor-specific cytotoxins which reverse multidrug resistance.

E. De Clercq, J. Molnár, J. Dimmock, 2009, Bioorganic & medicinal chemistry.

1,2,4-Triazole derivatives inhibiting the human immunodeficiency virus type 1 (HIV-1) in vitro

C. Pannecouque, P. Herdewijn, M. Froeyen, 2002 .

Synthesis, antimicrobial and antiviral activity of substituted benzimidazoles

B. Narasimhan, E. De Clercq, J. Balzarini, 2009, Journal of enzyme inhibition and medicinal chemistry.

Structural modification of diarylpyrimidine derivatives as HIV-1 reverse transcriptase inhibitors

E. De Clercq, C. Pannecouque, J. Balzarini, 2014, Medicinal Chemistry Research.

Synthesis and structure-activity relationship of novel diarylpyrimidines with hydromethyl linker (CH(OH)-DAPYs) as HIV-1 NNRTIs.

E. De Clercq, C. Pannecouque, Xiaodong Ma, 2011, Bioorganic & medicinal chemistry.

Bioinformatics analyses of the mannose-binding lectins from Polygonatum cyrtonema, Ophiopogon japonicus and Liparis noversa with antiproliferative and apoptosis-inducing activities.

J. Bao, J. Balzarini, Hao Peng, 2009, Phytomedicine.

Synthesis and antiretrovirus properties of 5'-isocyano-5'-deoxythymidine, 5'-isocyano-2',5'-dideoxyuridine, 3'-azido-5'-isocyano-3',5'-dideoxythymidine, and 3'-azido-5'-isocyano-2',3',5'-trideoxyuridine.

E. De Clercq, J. Balzarini, E. Zbiral, 1991, Journal of medicinal chemistry.

Synthesis, antiretrovirus effects, and phosphorylation kinetics of 3'-isocyano-3'-deoxythymidine and 3'-isocyano-2',3'-dideoxyuridine.

E. De Clercq, J. Balzarini, E. Zbiral, 1990, Journal of medicinal chemistry.

Synthesis of 3',4'-difluoro-3'-deoxyribonucleosides and its evaluation of the biological activities: discovery of a novel type of anti-HCV agent 3',4'-difluorocordycepin.

S. Shuto, N. Kato, J. Balzarini, 2014, Bioorganic & medicinal chemistry.

Lipophilic α‐hydroxybenzylphosphonates as prodrugs of 3′‐azido‐2′,3′‐dideoxythymidine (AZT)

J. Balzarini, E. D. Clercq, C. Meier, 1995 .

Synthesis and Biological Evaluation of a Series of Substituted Pyridine-C-Nucleosides. Part V: 3-Chloro-4-(D-Ribofuranosyl)Pyridine and 3-(D-Ribofuranosyl)-2-Pyridone

J. Balzarini, E. Clercq, R. Dommisse, 1989 .

Syntheses of 4-[1-(2-deoxy-β-D-ribofuranosyl)]-derivatives of 2-substituted-5-fluoroaniline: "cytosine replacement" analogs of deoxycytidine for evaluation as anticancer and antihuman immunodeficiency virus (anti-HIV) agents

J. Balzarini, E. Clercq, L. Wiebe, 2000 .

Novel imidazo[1,2-c]pyrimidine base-modified nucleosides: synthesis and antiviral evaluation.

E. De Clercq, N. Kifli, J. Balzarini, 2004, Bioorganic & medicinal chemistry.

Knocking out human immunodeficiency virus through non-nucleoside reverse transcriptase inhibitors used as single agents or in combinations: a paradigm for the cure of AIDS?

E. De Clercq, J. Balzarini, 1995, Farmaco.

Interaction of antimony(III) chloride with thiourea, 2-mercapto-5-methyl-benzimidazole, 3-methyl-2-mercaptobenzothiazole, 2-mercaptopyrimidine, and 2-mercaptopyridine

J. Balzarini, A. Tasiopoulos, M. Manos, 2011 .

Synthesis and Biological Evaluation of Novel 1′‐Branched and Spironucleoside Analogues

E. De Clercq, J. Balzarini, C. Chatgilialoglu, 2004, Nucleosides, Nucleotides & Nucleic Acids.

Scaffold hopping: exploration of acetanilide-containing uracil analogues as potential NNRTIs.

A. V. Ivanov, C. Pannecouque, J. Balzarini, 2015, Bioorganic & medicinal chemistry.

Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds.

J Desmyter, E. De Clercq, R. Pauwels, 1988, Journal of virological methods.

Discovery of 2-pyridone derivatives as potent HIV-1 NNRTIs using molecular hybridization based on crystallographic overlays.

Peng Zhan, Jan Balzarini, Christophe Pannecouque, 2014, Bioorganic & medicinal chemistry.

Current status of the non-nucleoside reverse transcriptase inhibitors of human immunodeficiency virus type 1.

J. Balzarini, J Balzarini, 2004, Current topics in medicinal chemistry.

Synthesis and Anti‐HIV Activity of 4‐(Naphthalen‐1‐yl)‐1,2,5‐thiadiazol‐3‐hydroxyl Derivatives

E. De Clercq, C. Pannecouque, P. Zhan, 2014, Chemical biology & drug design.

Phenylethylthiazolylthiourea (PETT) Non-nucleoside Inhibitors of HIV-1 and HIV-2 Reverse Transcriptases

Jan Balzarini, Robert M. Esnouf, Louise E. Bird, 2000, The Journal of Biological Chemistry.

Benzylidene-bis-(4-Hydroxycoumarin) and Benzopyrano-Coumarin Derivatives: Synthesis, 1H/13C-NMR Conformational and X-ray Crystal Structure Studies and In Vitro Antiviral Activity Evaluations

E. De Clercq, J. Plavec, J. Balzarini, 2011, Molecules.

Early restaging positron emission tomography with ( 18)F-fluorodeoxyglucose predicts outcome in patients with aggressive non-Hodgkin's lymphoma.

P. Dupont, L. Mortelmans, G. Verhoef, 2002, Annals of oncology : official journal of the European Society for Medical Oncology.

From β‐Amino‐γ‐sultone to Unusual Bicyclic Pyridine and Pyrazine Heterocyclic Systems: Synthesis and Cytostatic and Antiviral Activities

J. Balzarini, M. Camarasa, S. Velázquez, 2011, ChemMedChem.

Cytotoxic activities of Mannich bases of chalcones and related compounds.

T. Myers, E. De Clercq, J. Quail, 1998, Journal of medicinal chemistry.

Synthesis and Anti-HIV Evaluation of Novel 1,2,4-triazole Derivatives as Potential Non-nucleoside HIV-1 Reverse Transcriptase Inhibitors

C. Pannecouque, P. Zhan, Xinyong Liu, 2012 .

A microwave-assisted diastereoselective multicomponent reaction to access dibenzo[c,e]azepinones: synthesis and biological evaluation.

C. Pannecouque, J. Balzarini, E. V. Van der Eycken, 2011, The Journal of organic chemistry.

Design, synthesis and antiproliferative activity of novel heterobivalent hybrids based on imidazo[2,1-b][1,3,4]thiadiazole and imidazo[2,1-b][1,3]thiazole scaffolds.

J. Balzarini, S. Liekens, P. Baraldi, 2015, European journal of medicinal chemistry.

Synthesis and biological properties of 2-amino-3-fluoro-2,3-dideoxy-D-pentofuranosides of natural heterocyclic bases

J. Balzarini, E. Clercq, N. Poopeiko, 1991 .

Synthesis of 4-aminoquinoline–pyrimidine hybrids as potent antimalarials and their mode of action studies

K. Chibale, J. Balzarini, H. Kaur, 2013, European Journal of Medicinal Chemistry.

Synthesis and Biological Evaluation of New Antitubulin Agents Containing 2-(3′,4′,5′-trimethoxyanilino)-3,6-disubstituted-4,5,6,7-tetrahydrothieno[2,3-c]pyridine Scaffold

R. Gambari, A. Finotti, B. Cacciari, 2020, Molecules.

A new four-component reaction involving the Michael addition and the Gewald reaction, leading to diverse biologically active 2-aminothiophenes.

W. Dehaen, J. Balzarini, S. Liekens, 2017, Organic & biomolecular chemistry.

Bicyclic pyrimidine nucleoside analogues (BCNAs) as highly selective and potent inhibitors of varicella-zoster virus replication.

J. Balzarini, C. Mcguigan, C. Mcguigan*, 2002, The Journal of antimicrobial chemotherapy.

Non‐Nucleoside HIV‐1 Reverse Transcriptase Inhibitors. Part 13

C. Pannecouque, J. Balzarini, Fener Chen, 2009, Chemistry & biodiversity.

Non-nucleoside HIV-1 reverse transcriptase inhibitors. Part 11: structural modulations of diaryltriazines with potent anti-HIV activity.

Jan Balzarini, Christophe Pannecouque, E. De Clercq, 2008, European journal of medicinal chemistry.

Chiral synthesis of 4-[1-(2-deoxy-beta-L-ribofuranosyl)] derivatives of 2-substituted 5-fluoroaniline: "cytosine replacement" analogues of deoxy-beta-L-cytidine.

E. De Clercq, J. Balzarini, L. Wiebe, 2000, The Journal of organic chemistry.

Structure-activity relationship of novel oligopeptide antiviral and antitumor agents related to netropsin and distamycin.

E. De Clercq, J. Lown,, J. Balzarini, 1986, Journal of medicinal chemistry.

Synthesis and Biological Activity of the Mono- and Diamino Analogues of 2′-Deoxyadenosine, Cordycepin, 9-(3-Deoxy-α-D-Threo-Pentofuranosyl)-Adenine (A Structural Component of Agrocin 84) and 9-(2-Deoxy-α-D-Threo-Pentofuranosyl)Adenine

R. Pauwels, P. Herdewijn, G. Janssen, 1989 .

Design, synthesis, and biological evaluation of C1-phosphonamidate analogues of 2-deoxy-d-ribose-1-phosphate

J. Balzarini, C. Mcguigan, Maurizio Quintiliani, 2013 .

Design, synthesis, DNA binding, and biological evaluation of water-soluble hybrid molecules containing two pyrazole analogues of the alkylating cyclopropylpyrroloindole (CPI) subunit of the antitumor agent CC-1065 and polypyrrole minor groove binders.

G. Spalluto, J. Balzarini, T. Bando, 2001, Journal of medicinal chemistry.

PYRIDINE-TYPE COMPLEXES OF TRANSITION-METAL HALIDES .6. PREPARATION AND CHARACTERIZATION OF 2.6-DIMETHYLPYRIDINE AND 3,5-DIMETHYLPYRIDINE COMPLEXES OF COBALT(II) HALIDES - THE CRYSTAL-STRUCTURE OF DI(2.6-DIMETHYLPYRIDINIUM)TETRACHLOROCOBALTATE(II) AND DICHLOROTETRAKIS(3,5-DIMETHYLPYRIDINE)COBALT(II)

M. Leskelä, J. Kansikas, U. Ragnarsson, 1994 .

Anti-HIV Activities of Anionic Metalloporphyrins and Related Compounds

E. De Clercq, J. Balzarini, D. Schols, 1997 .

Geiparvarin analogues. 4. Synthesis and cytostatic activity of geiparvarin analogues bearing a carbamate moiety or a furocoumarin fragment on the alkenyl side chain.

E. De Clercq, J. Balzarini, S. Manfredini, 1994, Journal of Medicinal Chemistry.

Pyridine N-oxide derivatives: unusual anti-HIV compounds with multiple mechanisms of antiviral action.

E. De Clercq, C. Pannecouque, J. Balzarini, 2005, The Journal of antimicrobial chemotherapy.

Synthesis and Biological Activity of Novel 1H,3H-Thiazolo[3,4-a]Benzimidazoles: Non-nucleoside Human Immunodeficiency Virus Type 1 Reverse Transcriptase Inhibitors

E. De Clercq, C. Pannecouque, J. Balzarini, 1999, Antiviral chemistry & chemotherapy.

A conformational and structure-activity relationship study of cytotoxic 3,5-bis(arylidene)-4-piperidones and related N-acryloyl analogues.

E. De Clercq, J. Quail, J. Dimmock, 2001, Journal of medicinal chemistry.

Synthesis and antiviral/antitumor evaluation of 2-amino- and 2-carboxamido-3-arylsulfonylthiophenes and related compounds as a new class of diarylsulfones.

E. De Clercq, J. Balzarini, E. Clercq, 2001, Bioorganic & medicinal chemistry.

Cytotoxic analogues of 2,6-bis(arylidene)cyclohexanones.

Jan Balzarini, James P Stables, Theresa M Allen, 2003, European journal of medicinal chemistry.

Cytotoxic 2,6-bis(arylidene)cyclohexanones and related compounds.

J. Quail, J. Dimmock, J. Balzarini, 2000, European journal of medicinal chemistry.

Synthesis and biological evaluation of 2- and 3-aminobenzo[b]thiophene derivatives as antimitotic agents and inhibitors of tubulin polymerization.

Jan Balzarini, John A Hadfield, Andrea Brancale, 2007, Journal of medicinal chemistry.

Design, synthesis and preliminary antiviral screening of new N-phenylpyrazole and dihydroisoxazole derivatives

C. Pannecouque, J. Balzarini, G. Andrei, 2010, Medicinal Chemistry Research.

Synthesis and antiviral activity of new pyrazole and thiazole derivatives.

C. Pannecouque, J. Balzarini, G. Andrei, 2009, European journal of medicinal chemistry.

Regiospecific Synthesis and Anti-Human Immunodeficiency Virus Activity of Novel 5-Substituted N-Alkylcarbamoyl and N,N-Dialkyl Carbamoyl 1,2,3-Triazole-TSAO Analogues

E. De Clercq, F. Gago, J. Balzarini, 1998, Antiviral chemistry & chemotherapy.

Synthesis of phosphonate analogues of 2-deoxyribose-1-phosphate

J. Balzarini, M. Camarasa, M. Pérez-Pérez, 1998 .

A novel and easy two-step, microwave-assisted method for the synthesis of halophenyl pyrrolo[2,3-b]quinoxalines via their pyrrolo precursors. Evaluation of their bioactivity

W. Dehaen, D. Hadjipavlou-Litina, J. Balzarini, 2014 .

5-(Acylethynyl)uracils, 5-(Acylethynyl)-2'-deoxyuridines and 5-(Acylethynyl)-1-(2-hydroxyethoxy)methyluracils. Their synthesis, antiviral and cytotoxic activities

C. Spears, J. Balzarini, E. Clercq, 1999 .

Palladium-catalyzed synthesis of [E]-6-(2-acylvinyl)uracils and [E]-6-(2-acylvinyl)-1-[(2-hydroxyethoxy)methyl]uracils--their antiviral and cytotoxic activities.

E. De Clercq, J. Balzarini, E. Clercq, 1997, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of 2-(3',4',5'-trimethoxybenzoyl)-3-N,N-dimethylamino benzo[b]furan derivatives as inhibitors of tubulin polymerization.

R. Gambari, A. Brancale, O. Cruz-López, 2008, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of 1-methyl-2-(3',4',5'-trimethoxybenzoyl)-3-aminoindoles as a new class of antimitotic agents and tubulin inhibitors.

H. Hsieh, A. Brancale, O. Cruz-López, 2008, Journal of medicinal chemistry.

Synthesis of new 2,3-diaryl-1,3-thiazolidin-4-ones as anti-HIV agents.

Jan Balzarini, Angela Rao, Maria Zappalà, 2004, Farmaco.

Eco-friendly synthesis and biological evaluation of new quinoline-based dialkyl alpha-aminophosphonates

J. Balzarini, E. Clercq, L. Tušek-Boz̆ić, 2007 .

A novel lead for specific anti-HIV-1 agents: 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine.

R T Walker, R. T. Walker, E. De Clercq, 1989, Journal of medicinal chemistry.

Indolylarylsulfones as HIV-1 non-nucleoside reverse transcriptase inhibitors: new cyclic substituents at indole-2-carboxamide.

E. Novellino, C. Pannecouque, A. Coluccia, 2011, Journal of medicinal chemistry.

The Synthesis and Antiviral Activity of Some New S-Adenosyl-L-homocysteine Derivatives and Their Nucleoside Precursors

J. Balzarini, E. Clercq, P. Serafinowski, 1995 .

Synthesis and antiviral activity of some new S-adenosyl-L-homocysteine derivatives.

E. De Clercq, J. Balzarini, K. Harrap, 1992, Journal of medicinal chemistry.

Palladium(II) complexes of dialkyl alpha-Anilinobenzylphosphonates. Synthesis, characterization, and cytostatic activity.

E. De Clercq, D. Vikić-Topić, J. Balzarini, 1996, Journal of inorganic biochemistry.

Synthesis, Biological Evaluation and Ligand Based Pharmacophore Modeling of New Aromatic Thiosemicarbazones as Potential Anticancer Agents

J. Balzarini, E. E. Oruç-Emre, A. Karaküçük-Iyidoğan, 2019, Pharmaceutical Chemistry Journal.

Novel 3,5-bis(arylidene)-4-oxo-1-piperidinyl dimers: structure-activity relationships and potent antileukemic and antilymphoma cytotoxicity.

Stephen G. Dimmock, E. De Clercq, J. Dimmock, 2014, European journal of medicinal chemistry.

Pronounced Inhibition Shift from HIV Reverse Transcriptase to Herpetic DNA Polymerases by Increasing the Flexibility of α-Carboxy Nucleoside Phosphonates.

L. Naesens, E. Arnold, W. Dehaen, 2015, Journal of medicinal chemistry.

Novel Acyclic Phosphonylated 1,2,3‐Triazolonucleosides with an Acetamidomethyl Linker: Synthesis and Biological Activity

J. Balzarini, A. Wróblewski, I. Głowacka, 2014, Archiv der Pharmazie.

Design, synthesis, antiviral and cytostatic activity of ω-(1H-1,2,3-triazol-1-yl)(polyhydroxy)alkylphosphonates as acyclic nucleotide analogues

J. Balzarini, D. Schols, G. Andrei, 2014, Bioorganic & Medicinal Chemistry.

Synthesis of 1,2,3‐Triazolyl Nucleoside Analogs as Potential Anti‐Influenza A (H3N2 Subtype) Virus Agents

J. Balzarini, M. Smietana, J. Vasseur, 2014, Archiv der Pharmazie.

Design, synthesis, antiviral and cytotoxic evaluation of novel acyclic phosphonate nucleotide analogues with a 5,6-dihydro-1H-[1,2,3]triazolo[4,5-d]pyridazine-4,7-dione system

J. Balzarini, A. Wróblewski, I. Głowacka, 2014, Monatshefte für Chemie - Chemical Monthly.

The synthesis, antiviral, cytostatic and cytotoxic evaluation of a new series of acyclonucleotide analogues with a 1,2,3-triazole linker

J. Balzarini, A. Wróblewski, I. Głowacka, 2013, European Journal of Medicinal Chemistry.

Synthesis and Biological Evaluation of Novel 1,2,3‐Triazolonucleotides

J. Balzarini, A. Wróblewski, I. Głowacka, 2013, Archiv der Pharmazie.

Design, Synthesis, Antiviral, and Cytotoxic Evaluation of Novel Phosphonylated 1,2,3-Triazoles as Acyclic Nucleotide Analogues

J. Balzarini, A. Wróblewski, I. Głowacka, 2012, Nucleosides, nucleotides & nucleic acids.

Design, synthesis, antiviral and cytostatic evaluation of novel isoxazolidine nucleotide analogues with a 1,2,3-triazole linker

J. Balzarini, D. Piotrowska, I. Głowacka, 2011, European Journal of Medicinal Chemistry.

Synthesis of new C5-(1-substituted-1,2,3-triazol-4 or 5-yl)-2'-deoxyuridines and their antiviral evaluation.

J. Balzarini, G. Andrei, R. Snoeck, 2011, European journal of medicinal chemistry.

Efficient synthesis and in vitro cytostatic activity of 4-substituted triazolyl-nucleosides.

J. Balzarini, R. Benhida, K. Bougrin, 2007, Bioorganic & medicinal chemistry letters.

SYNTHESIS AND BIOLOGICAL ACTIVITIES OF (Z) AND (E) α-ETHENYL ACYCLONUCLEOSIDES

E. De Clercq, J. Balzarini, M. Witvrouw, 2001 .

Synthesis of (Z) and (E) α-Alkenyl Phosphonic Acid Derivatives of Purines and Pyrimidines.

C. Pannecouque, J. Balzarini, E. Clercq, 1998 .

5-alkynyl analogs of arabinouridine and 2'-deoxyuridine: cytostatic activity against herpes simplex virus and varicella-zoster thymidine kinase gene-transfected cells.

E. De Clercq, J. Balzarini, G. Andrei, 2007, Journal of medicinal chemistry.

Bis[3,5‐bis(benzylidene)‐4‐oxo‐1‐piperidinyl]amides: A Novel Class of Potent Cytotoxins

Stephen G. Dimmock, J. Dimmock, J. Balzarini, 2011, ChemMedChem.

Highly specific inhibition of human immunodeficiency virus type 1 by a novel 6-substituted acyclouridine derivative.

R T Walker, R. T. Walker, E. De Clercq, 1989, Biochemical and biophysical research communications.

Synthesis and antiviral activity of imidazo[1,2-a]pyridines

E. De Clercq, J. Chezal, J. Balzarini, 1999 .

Branched-chain C-cyano pyranonucleosides: Synthesis of 3′-C-cyano & 3′-C-cyano-3′-deoxy pyrimidine pyranonucleosides as novel cytotoxic agents

J. Balzarini, S. Manta, V. Parmenopoulou, 2011, European Journal of Medicinal Chemistry.

Human Mitochondrial Thymidine Kinase Is Selectively Inhibited by 3′-Thiourea Derivatives of β-Thymidine: Identification of Residues Crucial for Both Inhibition and Catalytic Activity

S. van Calenbergh, F. Gago, J. Balzarini, 2009, Molecular Pharmacology.

Cytotoxic N-[4-(3-aryl-3-oxo-1-propenyl)phenylcarbonyl]-3,5-bis(phenylmethylene)-4-piperidones and related compounds.

E. De Clercq, J. Quail, J. Dimmock, 2002, European journal of medicinal chemistry.

Deoxyribonucleoside 2'- or 3'-mixed disulfides: prodrugs to target ribonucleotide reductase and/or to inhibit HIV reverse transcription.

J. Balzarini, J. Décout, A. Aubertin, 2003, Journal of medicinal chemistry.

Synthesis and antiviral and cytostatic evaluations of the new C-5 substituted pyrimidine and furo[2,3-d]pyrimidine 4',5'-didehydro-L-ascorbic acid derivatives.

E. De Clercq, K. Pavelić, M. Kralj, 2007, Journal of medicinal chemistry.

Geiparvarin analogues. 3. Synthesis and cytostatic activity of 3(2H)-furanone and 4,5-dihydro-3(2H)-furanone congeners of geiparvarin, containing a geraniol-like fragment in the side chain.

E. De Clercq, J. Balzarini, S. Manfredini, 1992, Journal of medicinal chemistry.

Synthesis and antiviral evaluation of cis-substituted cyclohexenyl and cyclohexanyl nucleosides.

E. De Clercq, J. Courcambeck, J. Neyts, 2005, Journal of medicinal chemistry.

Synthesis and antitumor activities of novel pyrimidine derivatives of 2,3-O,O-dibenzyl-6-deoxy-L-ascorbic acid and 4,5-didehydro-5,6- dideoxy-L-ascorbic acid.

E. De Clercq, J. Balzarini, A. Nagl, 2000, Journal of medicinal chemistry.

Resistance pattern of human immunodeficiency virus type 1 reverse transcriptase to quinoxaline S-2720

E. De Clercq, J. Balzarini, A. Karlsson, 1994, Journal of virology.

2',5'-Bis-O-(tert-butyldimethylsilyl)-3'-spiro-5''-(4''-amino-1'',2''- oxathiole-2'',2'-dioxide)pyrimidine (TSAO) nucleoside analogues: highlyselective inhibitors of human immunodeficiency virus type 1 that are targeted at the viral reverse transcriptase.

E. De Clercq, A. Vandamme, C. Perno, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Synthesis and antiviral evaluation of 6-(alkyl-heteroaryl)furo[2,3-d]pyrimidin-2(3H)-one nucleosides and analogues with ethynyl, ethenyl, and ethyl spacers at C6 of the furopyrimidine core.

E. De Clercq, J. Balzarini, J. Cannon, 2007, Journal of medicinal chemistry.

A thymidine phosphorylase-stable analogue of BVDU with significant antiviral activity.

E. De Clercq, J. Balzarini, V. Nair, 2002, Journal of medicinal chemistry.

Synthesis and antiviral activity of the enantiomeric forms of carba-5-iodo-2'-deoxyuridine and carba-(E)-5-(2-bromovinyl)-2'-deoxyuridine.

E. De Clercq, J. Balzarini, H. Griengl, 1989, Journal of medicinal chemistry.

Synthesis and antiviral activity of the carbocyclic analogues of (E)-5-(2-halovinyl)-2'-deoxyuridines and (E)-5-(2-halovinyl)-2'-deoxycytidines.

E. De Clercq, P. Herdewijn, J. Balzarini, 1985, Journal of medicinal chemistry.

Facile transformation of Biginelli pyrimidin-2(1H)-ones to pyrimidines. In vitro evaluation as inhibitors of Mycobacterium tuberculosis and modulators of cytostatic activity.

K. Chibale, J. Balzarini, S. Franzblau, 2011, European journal of medicinal chemistry.

Sodium and potassium benzeneazophosphonate complexes with crown ethers: solid-state microwave synthesis, characterization and biological activity

C. Pannecouque, J. Balzarini, E. Clercq, 2009 .

Structure-activity relationship study on anti-HIV 6-desfluoroquinolones.

C. Pannecouque, J. Balzarini, D. Daelemans, 2008, Journal of medicinal chemistry.

Broad-Spectrum Antiviral Activity and Mechanism of Antiviral Action of the Fluoroquinolone Derivative K-12

E. De Clercq, C. Pannecouque, A. Vandamme, 1998, Antiviral chemistry & chemotherapy.

Second‐Generation cycloSal‐d4TMP Pronucleotides Bearing Esterase‐Cleavable Sites — The “Trapping” Concept

J. Balzarini, C. Ducho, C. Meier, 2006 .

Second Generation of cycloSal‐Pronucleotides with Esterase‐Cleavable Sites: The ”Lock‐In”‐Concept

J. Balzarini, C. Meier, D. Vukadinović, 2004, Nucleosides, nucleotides & nucleic acids.

Synthesis and Biological Evaluation of Novel 1′‐Branched and Spironucleoside Analogues

E. De Clercq, J. Balzarini, C. Chatgilialoglu, 2004, Nucleosides, nucleotides & nucleic acids.

Synthesis of adamantane spiro sultones as potential antiviral agents

M. Hosoya, J. Balzarini, E. Clercq, 1992 .

Synthesis of 4,6-dideoxy-3-fluoro-2-keto-beta-D-glucopyranosyl analogues of 5-fluorouracil, N6-benzoyl adenine, uracil, thymine, N4-benzoyl cytosine and evaluation of their antitumor activities.

J. Balzarini, S. Manta, D. Komiotis, 2010, Bioorganic chemistry.

Synthesis of Pyranose Nucleosides

P. Herdewijn, A. Aerschot, J. Balzarini, 1991 .

5'-O-tritylinosine and analogues as allosteric inhibitors of human thymidine phosphorylase.

J. Balzarini, S. Liekens, M. Camarasa, 2006, Journal of medicinal chemistry.

Synthesis and antiviral properties of (+/-)-5'-noraristeromycin and related purine carbocyclic nucleosides. A new lead for anti-human cytomegalovirus agent design.

E. De Clercq, M. Hosoya, J. Balzarini, 1992, Journal of medicinal chemistry.

Stereocontrolled Facile Synthesis and Biological Evaluation of (3′S) and (3′R)-3′-Amino (and Azido)-3′-Deoxy Pyranonucleosides

J. Balzarini, A. Dimopoulou, S. Manta, 2012, Nucleosides, nucleotides & nucleic acids.

Synthesis and anti-HIV activity of different sugar-modified pyrimidine and purine nucleosides.

E. De Clercq, R. Pauwels, P. Herdewijn, 1988, Journal of medicinal chemistry.

SYNTHESIS AND ANTI-HIV-1 ACTIVITY OF 4- AND 5-SUBSTITUTED 1,2,3-TRIAZOLE-TSAO DERIVATIVES

J. Balzarini, E. Clercq, M. Camarasa, 1995 .

TSAO analogues. 3. Synthesis and anti-HIV-1 activity of 2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl 3'-spiro-5''-(4''-amino-1'',2''-oxathiole 2'',2''-dioxide) purine and purine-modified nucleosides.

E. De Clercq, J. Balzarini, M. Camarasa, 1993, Journal of medicinal chemistry.

Synthesis and Antiviral Activity of Novel Fluorinated 2′,3′‐Dideoxynucleosides

E. De Clercq, J. Balzarini, Piyush Kumar, 2004, Nucleosides, nucleotides & nucleic acids.

Antinociceptive and antitumor activity of novel synthetic mononuclear Ruthenium (II) compounds

E. De Clercq, J. Balzarini, Satyavati Dhulipala, 2013, Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences.

Regioselective synthesis of 6-substituted-2-amino-5-bromo-4(3H)-pyrimidinones and evaluation of their antiviral activity

J. Balzarini, Kamaljit Singh, Kawaljit Singh, 2013, European Journal of Medicinal Chemistry.

Design, synthesis, and biological evaluation of thiophene analogues of chalcones.

A. Brancale, O. Cruz-López, J. Balzarini, 2008, Bioorganic & medicinal chemistry.

Novel multi-targeting anthra[2,3-b]thiophene-5,10-diones with guanidine-containing side chains: interaction with telomeric G-quadruplex, inhibition of telomerase and topoisomerase I and cytotoxic properties.

V. Mitkevich, J. Balzarini, D. Azhibek, 2014, European journal of medicinal chemistry.

Synthesis and anti-HIV studies of 2-adamantyl-substituted thiazolidin-4-ones.

J. Balzarini, J. Maurin, A. Orzeszko, 2007, European journal of medicinal chemistry.

Microwave-assisted synthesis of a novel class of imidazolylthiazolidin-4-ones and evaluation of its biological activities

J. Balzarini, E. V. Van der Eycken, K. Van Hecke, 2010, Molecular Diversity.

Synthesis and biological evaluation of 6-(alkyn-1-yl)furo[2,3-d]pyrimidin-2(3H)-one base and nucleoside derivatives.

E. De Clercq, J. Balzarini, G. Andrei, 2006, Journal of medicinal chemistry.

Synthesis and biological evaluation of acyclic 3-[(2-hydroxyethoxy)methyl] analogues of antiviral furo- and pyrrolo[2,3-d]pyrimidine nucleosides.

E. De Clercq, J. Balzarini, G. Andrei, 2005, Journal of medicinal chemistry.

Design, Synthesis, Antiviral, and Cytostatic Evaluation of Novel Isoxazolidine Analogs of Homonucleotides

J. Balzarini, D. Piotrowska, M. Łysakowska, 2014, Archiv der Pharmazie.

N1,N3-disubstituted uracils as nonnucleoside inhibitors of HIV-1 reverse transcriptase

A. V. Ivanov, C. Pannecouque, J. Balzarini, 2013, Bioorganic & Medicinal Chemistry.

1‐Amino‐3‐(1H‐1,2,3‐triazol‐1‐yl)propylphosphonates as Acyclic Analogs of Nucleotides

J. Balzarini, D. Piotrowska, I. Głowacka, 2014, Archiv der Pharmazie.

6-azapyrimidine-2'-deoxy-4'-thionucleosides: antiviral agents against TK+ and TK- HSV and VZV strains.

E. De Clercq, J. Balzarini, C. Simons, 2004, Journal of medicinal chemistry.

Synthesis and antiviral activity of phosphonate derivatives of enantiomeric dihydro-2H-pyranyl nucleosides.

P. Herdewijn, J. Rozenski, J. Balzarini, 1995 .

Synthesis and biological evaluation of 2-(3',4',5'-trimethoxybenzoyl)-3-amino 5-aryl thiophenes as a new class of tubulin inhibitors.

J. Balzarini, M. Jordan, P. Baraldi, 2006, Journal of medicinal chemistry.

3,5-Bis(Phenylmethylene)-1-(N-arylmaleamoyl)-4-piperidones: A Novel Group of Cytotoxic Agents

E. De Clercq, R. Sharma, J. Dimmock, 2003, Journal of enzyme inhibition and medicinal chemistry.

Synthesis and biological evaluation of 5-(alkyn-1-yl)-1-(p-toluenesulfonyl)uracil derivatives

J. Balzarini, E. Clercq, G. Andrei, 2006 .

Efficient synthesis and in vitro cytostatic activity of 4-substituted triazolyl-nucleosides.

J. Balzarini, R. Benhida, K. Bougrin, 2007, Bioorganic & medicinal chemistry letters.

2-(2,6-Dihalophenyl)-3-(pyrimidin-2-yl)-1,3-thiazolidin-4-ones as non-nucleoside HIV-1 reverse transcriptase inhibitors.

E. De Clercq, C. Pannecouque, J. Balzarini, 2004, Antiviral research.

Cytotoxic and anticonvulsant aryloxyaryl Mannich bases and related compounds.

E. De Clercq, J. Dimmock, J. Balzarini, 2004, European journal of medicinal chemistry.

The novel C-5 aryl, alkenyl, and alkynyl substituted uracil derivatives of L-ascorbic acid: synthesis, cytostatic, and antiviral activity evaluations.

Jan Balzarini, Marko Marjanović, E. De Clercq, 2007, Bioorganic & medicinal chemistry.

Hybrid diarylbenzopyrimidine non-nucleoside reverse transcriptase inhibitors as promising new leads for improved anti-HIV-1 chemotherapy.

E. De Clercq, C. Pannecouque, J. Balzarini, 2010, Bioorganic & medicinal chemistry.

Geiparvarin analogues. 2. Synthesis and cytostatic activity of 5-(4-arylbutadienyl)-3(2H)-furanones and of N-substituted 3-(4-oxo-2-furanyl)-2-buten-2-yl carbamates.

E. De Clercq, J. Balzarini, S. Manfredini, 1991, Journal of medicinal chemistry.

Synthesis and cytostatic activity of geiparvarin analogues.

E. De Clercq, J. Balzarini, S. Manfredini, 1989, Journal of medicinal chemistry.

Pyridine-Substituted Hydroxythiophenes. III. Dimerization of 3-(2-Pyridyl)thiophen-2(5H)-one from the Demethylation Reaction of 2-Methoxy-3-(2-pyridyl)thiophene. X-Ray Structure Determination of (+-)-(3R*,4S*)-3-(2-Pyridyl)-4-[2-oxo-3-(1,2-dihydropyridin-2-ylidene)-2,3-dihydrothiophen-5-yl]-4,5-dihy

D. Aksnes, S. Gronowitz, U. Ragnarsson, 1994 .

Synthesis and cytostatic evaluation of some 2-(5-substituted-2-oxoindolin-3-ylidene)-N-substituted hydrazine carbothioamide

J. Balzarini, E. Clercq, A. Kulkarni, 2011, Medicinal Chemistry Research.

N-substituted pyrrole-based scaffolds as potential anticancer and antiviral lead structures.

J. Balzarini, K. Pegklidou, Petros L Gkizis, 2015, Medicinal chemistry (Shariqah (United Arab Emirates)).

Synthesis and broad spectrum antiviral evaluation of bis(POM) prodrugs of novel acyclic nucleosides

César A. Urbina-Blanco, R. Schinazi, J. Balzarini, 2013, European Journal of Medicinal Chemistry.

Structure–Activity Relationship of Tumor‐Selective 5‐Substituted 2‐Amino‐3‐carboxymethylthiophene Derivatives

W. Dehaen, J. Balzarini, S. Liekens, 2014, ChemMedChem.

2-aminothiophene-3-carboxylic acid ester derivatives as novel highly selective cytostatic agents

W. Dehaen, J. Balzarini, S. Noppen, 2014, Investigational New Drugs.

Synthesis and biological evaluation of 1,2-disubstituted carbonucleosides of 2-amino-6-substituted purine and 8-azapurine.

L. Santana, E. Uriarte, E. De Clercq, 1998, Bioorganic & medicinal chemistry letters.

Synthesis and anti-HIV activity of 2-naphthyl substituted DAPY analogues as non-nucleoside reverse transcriptase inhibitors.

C. Pannecouque, J. Balzarini, E. Clercq, 2010, Bioorganic & medicinal chemistry.

Novel C-6 fluorinated acyclic side chain pyrimidine derivatives: synthesis, (1)H and (13)C NMR conformational studies, and antiviral and cytostatic evaluations.

K. Pavelić, J. Plavec, M. Kralj, 2007, Journal of medicinal chemistry.

Synthesis, anticancer and cytostatic activity of some 6H-indolo[2,3-b]quinoxalines

E. De Clercq, J. Balzarini, Sujeet Kumar, 2009, Acta pharmaceutica.

Methyl-2-arylidene hydrazinecarbodithioates: synthesis and biological activity

T. Szekeres, J. Balzarini, U. Kulandaivelu, 2013, Chemical Papers.

N-aminoimidazole derivatives inhibiting retroviral replication via a yet unidentified mode of action.

E. De Clercq, C. Pannecouque, P. Herdewijn, 2003, Journal of medicinal chemistry.

Synthesis and anti‐HIV Studies of 2‐Adamantyl‐substituted Thiazolidin‐4‐ones.

J. Balzarini, J. Maurin, A. Orzeszko, 2007 .

Quinoline-pyrimidine hybrids: synthesis, antiplasmodial activity, SAR, and mode of action studies.

K. Chibale, Peter J. Smith, J. Balzarini, 2014, Journal of medicinal chemistry.

Spirobipyridopyrans, spirobinaphthopyrans, indolinospiropyridopyrans, indolinospironaphthopyrans and indolinospironaphtho-1,4-oxazines: synthesis, study of X-ray crystal structure, antitumoral and antiviral evaluation.

E. De Clercq, K. Pavelić, Linda Tomašković, 2004, Bioorganic & medicinal chemistry.

E. De Clercq, J. Balzarini, F. Hansske, 1987, Journal of medicinal chemistry.

Structure-activity relationships of [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]- 3'-spiro-5' '-(4' '-amino-1' ',2' '-oxathiole-2' ',2' '-dioxide)thymine derivatives as inhibitors of HIV-1 reverse transcriptase dimerization.

J. Balzarini, M. Camarasa, S. Velázquez, 2006, Journal of medicinal chemistry.

Molecular modifications of 2-arylidene-1-indanones leading to increased cytotoxic potencies

J. Dimmock, J. Balzarini, E. Clercq, 2007, Journal of enzyme inhibition and medicinal chemistry.

Preliminary validation of varicella zoster virus thymidine kinase as a novel reporter gene for PET.

J. Nuyts, L. Mortelmans, G. Bormans, 2012, Nuclear medicine and biology.

Synthesis and biological evaluation of acyclic nucleotide analogues with a furo(2,3-d)pyrimidin- 2(3H)-one base

R. Pohl, J. Balzarini, E. Clercq, 2010 .

Synthesis and biological evaluation of carbon-11-labeled acyclic and furo[2,3-d]pyrimidine derivatives of bicyclic nucleoside analogues (BCNAs) for structure–brain uptake relationship study of BCNA tracers

G. Bormans, A. Verbruggen, J. Balzarini, 2008 .

Mutations Distal to the Substrate Site Can Affect Varicella Zoster Virus Thymidine Kinase Activity: Implications for Drug Design

D. Stammers, L. Bird, J. Balzarini, 2006, Molecular Pharmacology.

Susceptibilities of Several Clinical Varicella-Zoster Virus (VZV) Isolates and Drug-Resistant VZV Strains to Bicyclic Furano Pyrimidine Nucleosides

J. Balzarini, E. Clercq, C. Mcguigan, 2005, Antimicrobial Agents and Chemotherapy.

Non-Nucleoside Structures Retain Full Anti-HCMV Potency of the Dideoxy Furanopyrimidine Family

E. De Clercq, O. Bidet, J. Balzarini, 2004, Antiviral chemistry & chemotherapy.

Crystal Structure of Varicella Zoster Virus Thymidine Kinase*

Jan Balzarini, Louise E. Bird, D. Stammers, 2003, Journal of Biological Chemistry.

Lack of susceptibility of bicyclic nucleoside analogs, highly potent inhibitors of varicella-zoster virus, to the catabolic action of thymidine phosphorylase and dihydropyrimidine dehydrogenase.

R. Esnouf, E. De Clercq, A. V. van Kuilenburg, 2002, Molecular pharmacology.

Chemotherapy of varicella-zoster virus by a novel class of highly specific anti-VZV bicyclic pyrimidine nucleosides.

J. Balzarini, C. Mcguigan, C. Mcguigan*, 2002, Biochimica et biophysica acta.

Susceptibilities of several drug-resistant varicella-zoster virus (VZV) strains to bicyclic pyrimidine nucleoside analogues (BCNAs)

L. Naesens, J. Balzarini, E. Clercq, 2002 .

Specific recognition of the bicyclic pyrimidine nucleoside analogs, a new class of highly potent and selective inhibitors of varicella-zoster virus (VZV), by the VZV-encoded thymidine kinase.

E. De Clercq, L. Naesens, A. Brancale, 2002, Molecular pharmacology.

Highly potent and selective inhibition of varicella-zoster virus by bicyclic furopyrimidine nucleosides bearing an aryl side chain.

J. T. Erichsen, J. Erichsen, E. De Clercq, 2000, Journal of medicinal chemistry.

Potent and selective inhibition of varicella-zoster virus (VZV) by nucleoside analogues with an unusual bicyclic base.

E. De Clercq, A. Brancale, J. Balzarini, 1999, Journal of medicinal chemistry.

Combined effects of bromovinyldeoxyuridine and fractionated or continuous administration of 5-fluorouracil in P388 leukemia-bearing mice.

E. De Clercq, R. Pauwels, H. Keizer, 1988, Cancer letters.

Effect of (E)-5-(2-bromovinyl)uracil on the catabolism and antitumor activity of 5-fluorouracil in rats and leukemic mice.

E. De Clercq, P. Herdewijn, J. Balzarini, 1986, Cancer research.

Phosphorolysis of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and other 5-substituted-2'-deoxyuridines by purified human thymidine phosphorylase and intact blood platelets.

E. De Clercq, J. Balzarini, C. Desgranges, 1983, Biochemical pharmacology.

Synthesis of acyclo-C-nucleosides in the imidazo[1,2-a]pyridine and pyrimidine series as antiviral agents.

E. De Clercq, J. Balzarini, M. Witvrouw, 1996, Journal of medicinal chemistry.

SYNTHESIS, CHARACTERIZATION AND CYTOTOXIC ACTIVITY OF SOME Ru(II) COMPLEXES

J. Balzarini, E. D. Clercq, Arpit Katiyar, 2011 .

Furano Pyrimidines as Novel Potent and Selective Anti-VZV Agents

E. De Clercq, A. Brancale, O. Bidet, 2001, Antiviral chemistry & chemotherapy.

Benzothiazole Derivatives as Multifunctional Antioxidant Agents for Skin Damage: Structure–Activity Relationship of a Scaffold Bearing a Five-Membered Ring System

J. Balzarini, S. Liekens, S. Manfredini, 2022, Antioxidants.

Acyclic Nucleoside Analogues as Novel Inhibitors of Human Mitochondrial Thymidine Kinase

J. Balzarini, A. Karlsson, M. Camarasa, 2002 .

TSAO compounds: the comprehensive story of a unique family of HIV-1 specific inhibitors of reverse transcriptase.

F. Gago, J. Balzarini, M. Camarasa, 2004, Current topics in medicinal chemistry.

Synthesis and antiviral evaluation of 3-hydroxy-2-methylpyridin-4-one dideoxynucleoside derivatives.

E. De Clercq, J. Neyts, J. Balzarini, 2003, Bioorganic & medicinal chemistry letters.

New antimony(III) bromide complexes with thioamides: synthesis, characterization, and cytostatic properties.

J. Balzarini, A. Tasiopoulos, N. Hadjiliadis, 2009, Inorganic chemistry.

Synthesis, determination of sequence selective DNA minor groove binding and biological evaluation of hybrid bithiazole-linked netropsin derivatives

C. Bailly, J. Lown,, J. Zimmermann, 1992 .

Synthesis, DNA binding and biological activity of oxazolopyridocarbazole-netropsin hybrid molecules

C. Paoletti, J. Balzarini, E. Clercq, 1991 .

Synthesis, DNA binding properties and biological evaluation of novel oligo-meta-benzamides related to netropsin

C. Paoletti, J. Balzarini, E. Clercq, 1991 .

Molecular Dynamics Simulation of Sucrose in Aqueous and Dimethyl Sulfoxide Solution.

M. Odelius, A. Laaksonen, U. Ragnarsson, 1994 .

Structure-activity relationship studies of a series of antiviral and antibacterial aglycon derivatives of the glycopeptide antibiotics vancomycin, eremomycin, and dechloroeremomycin.

E. De Clercq, M. Preobrazhenskaya, J. Balzarini, 2005, Journal of medicinal chemistry.

Inhibition of feline (FIPV) and human (SARS) coronavirus by semisynthetic derivatives of glycopeptide antibiotics

E. De Clercq, M. Van Ranst, M. Preobrazhenskaya, 2006, Antiviral Research.

Non-nucleoside reverse transcriptase inhibitors (Part 18): synthesis and anti-HIV activity of 4-allylamino or 4-azido substituted diaryltriazines.

E. De Clercq, C. Pannecouque, J. Balzarini, 2009, Yao xue xue bao = Acta pharmaceutica Sinica.

Skin Damages—Structure Activity Relationship of Benzimidazole Derivatives Bearing a 5-Membered Ring System

J. Balzarini, S. Liekens, S. Manfredini, 2020, Molecules.

Acyclic nucleoside analogues as novel inhibitors of human mitochondrial thymidine kinase.

J. Balzarini, A. Karlsson, M. Camarasa, 2002, Journal of medicinal chemistry.

Niacin esters of chalcones with tumor-selective properties

E. De Clercq, J. Dimmock, J. Balzarini, 2016, Journal of enzyme inhibition and medicinal chemistry.

Imidazothiadiazine dioxides: synthesis and antiviral activity.

E. De Clercq, J. Balzarini, R. Snoeck, 1999, Bioorganic & medicinal chemistry.

Copper(II) Complexes of 2-Amino-2-hydroxymethyl-1,3-propanediol. Part 5. Synthesis, Structure and Thermal Behavior of cis-[2-Amino-2-hydroxymethyl-1,3-propanediol-O,O,N][2-amino-2-hydroxymethyl-1,3-propanediolato-O,N]aquacopper(II) Halide Monohydrate [Cu(C4H10NO3)(C4H11NO3)(H2O)]X.H2O, where X = F-,

Jonathan P. Wright, U. Ragnarsson, J. Balzarini, 1994 .

Geiparvarin Analogues. Part 4. Synthesis and Cytostatic Activity of Geiparvarin Analogues Bearing a Carbamate Moiety or a Furocoumarin Fragment on the Alkenyl Side Chain.

J. Balzarini, E. Clercq, S. Manfredini, 1994 .

Novel adamantylated pyrimidines and their preliminary biological evaluations.

J. Balzarini, A. Laudy, B. Starościak, 2004, Farmaco.

Stereospecific synthesis and biological evaluations of beta-L-pentofuranonucleoside derivatives of 5-fluorouracil and 5-fluorocytosine.

E. De Clercq, J. Balzarini, J. Sommadossi, 2001, European journal of medicinal chemistry.

Arylazolyl(azinyl)thioacetanilides. Part 16: Structure-based bioisosterism design, synthesis and biological evaluation of novel pyrimidinylthioacetanilides as potent HIV-1 inhibitors.

Peng Zhan, Jan Balzarini, Christophe Pannecouque, 2014, Bioorganic & medicinal chemistry.

Structural Features and Anti-Human Immunodeficiency Virus (HIV) Activity of the Isomers of 1-(2′,6′-Difluorophenyl)-1H,3H-Thiazolo[3,4-a]Benzimidazole, a Potent Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitor

E. De Clercq, J. Balzarini, M. Witvrouw, 1997 .

Antiviral Activity of low-MW Dextran Sulphate (Derived from dextran MW 1000) Compared to Dextran Sulphate Samples of Higher MW

E. De Clercq, R. Pauwels, M. Hosoya, 1991 .

Synthesis and Anti‐herpetic Activity of Phosphoramidate ProTides

P. Herdewijn, J. Balzarini, G. Andrei, 2013, ChemMedChem.

Synthesis and Biological Evaluation of Some D-Arabino- and D-Lyxofuranosyl-Pyridine C-Nucleosides

J. Balzarini, E. Clercq, E. Esmans, 1994 .

Synthesis of 2'-azido-2',3'-didehydro-2',3'-dideoxythymidine

J. Balzarini, F. Seela, E. D. Clercq, 1993 .

Synthesis and Biological Evaluation of Some D-Xylofuranosyl-Pyridine C-Nudeosides

J. Balzarini, E. Clercq, R. Dommisse, 1991 .

5-Substituted 2'-deoxyuridines: correlation between inhibition of tumor cell growth and inhibition of thymidine kinase and thymidylate synthetase.

E. De Clercq, J. Balzarini, D. Shugar, 1982, Biochemical pharmacology.

Syntheses of 1-[(2-Hydroxyethoxy)methyl]- and 1-[(1,3-Dihydroxy-2-Propoxy)methyl]- Derivatives of 5-Substituted-2,4-difluorobenzene: Unnatural Acyclo Thymidine Mimics for Evaluation as Anticancer and Antiviral Agents

J. Balzarini, E. Clercq, L. Wiebe, 2000, Nucleosides, nucleotides & nucleic acids.

Synthesis of Guanine α-Carboxy Nucleoside Phosphonate (G-α-CNP), a Direct Inhibitor of Multiple Viral DNA Polymerases.

A. Maguire, J. Balzarini, A. Ford, 2018, The Journal of organic chemistry.

Exploring the role of the α-carboxyphosphonate moiety in the HIV-RT activity of α-carboxy nucleoside phosphonates.

E. Arnold, K. Das, A. Maguire, 2016, Organic & biomolecular chemistry.

Synthesis and biological evaluation of a carbocyclic azanoraristeromycin siderophore conjugate.

E. De Clercq, M. Miller, J. Balzarini, 1999, Nucleosides & nucleotides.

Novel Human Immunodeficiency Virus (HIV) Inhibitors That Have a Dual Mode of Anti-HIV Action

E. De Clercq, C. Pannecouque, J. Balzarini, 2003, Antimicrobial Agents and Chemotherapy.

Inhibition of Human Immunodeficiency Virus by a New Class of Pyridine Oxide Derivatives

E. De Clercq, C. Pannecouque, J. Balzarini, 2003, Antimicrobial Agents and Chemotherapy.

Pyridine oxide derivatives: structure-activity relationship for inhibition of human immunodeficiency virus and cytomegalovirus replication in cell culture

C. Pannecouque, J. Balzarini, E. Clercq, 2002 .

Synthesis of Novel Nucleoside Analogues Built on a Bicyclo[4.1.0]heptane Scaffold.

Jean‐Didier Maréchal, J. Balzarini, M. Figueredo, 2015, The Journal of organic chemistry.

Synthesis, cytostatic and anti-HIV evaluations of the new unsaturated acyclic C-5 pyrimidine nucleoside analogues

L. Naesens, K. Pavelić, J. Plavec, 2008, Bioorganic & Medicinal Chemistry.

SYNTHESIS OF AMINO ACIDS WITH MODIFIED PRINCIPAL PROPERTIES. III: SULFUR-CONTAINING AMINO ACIDS

R. Carlson, U. Ragnarsson, J. Balzarini, 1994 .

Antiproliferative and Antiviral Activity of Three Libraries of Adamantane Derivatives

E. De Clercq, J. Balzarini, N. Basarić, 2014, Archiv der Pharmazie.

Phenylboronic-Acid-Based Carbohydrate Binders as Antiviral Therapeutics: Bisphenylboronic Acids

J. Balzarini, C. Mcguigan, P. Trippier, 2010, Antiviral chemistry & chemotherapy.

Speciation in Vanadium Bioinorganic Systems. 1. A Potentiometric and 51V NMR Study of Aqueous Equilibria in the H+--Vanadate(V)--L-alpha-Alanyl-L-histidine System.

D. Aksnes, U. Ragnarsson, J. Balzarini, 1994 .

Computational strategies in discovering novel non-nucleoside inhibitors of HIV-1 RT.

Jan Balzarini, Angela Rao, Maria Zappalà, 2005, Journal of medicinal chemistry.

Pyridine-Type Complexes of Transition-Metal Halides. VIII. Preparation, Characterization and Single-Crystal Structure of Difluorotetrakis(3,5-dimethylpyridine)cobalt(II).n Hydrate [n ~= 2.6(3)].

U. Ragnarsson, J. Balzarini, G. Francis, 1994 .

Design and synthesis of N₁-aryl-benzimidazoles 2-substituted as novel HIV-1 non-nucleoside reverse transcriptase inhibitors.

C. Pannecouque, J. Balzarini, S. Ferro, 2014, Bioorganic & medicinal chemistry.

Comparative Study of Bis(Benzyl)Phosphate Triesters of 2′,3′-Dideoxy-2′,3′-Didehydrothymidine (d4T) and CycloSal-d4TMP — Hydrolysis, Mechanistic Insights and Anti-HIV Activity

E. De Clercq, L. Naesens, J. Balzarini, 2002, Antiviral chemistry & chemotherapy.

Antiproliferative activities of halogenated thieno[3,2-d]pyrimidines.

G. M. Wilson, J. Balzarini, C. Salomon, 2014, Bioorganic & medicinal chemistry.

Resolution of aristeromycin enantiomers.

E. De Clercq, P. Herdewijn, J. Balzarini, 1985, Journal of medicinal chemistry.

Synthesis and preliminary biological evaluation of new anti-tubulin agents containing different benzoheterocycles.

E. De Clercq, J. Balzarini, P. Baraldi, 2005, Bioorganic & medicinal chemistry letters.

Alkenyl substituted bicyclic nucleoside analogues retain nanomolar potency against Varicella Zoster Virus.

O. Bidet, J. Balzarini, Marco Derudas, 2009, Bioorganic & medicinal chemistry.

Synthesis of Unusual Bicyclic Nucleosides Bearing an Unsaturated Side-Chain, as Potential Inhibitors of Varicella-Zoster Virus (VZV)

E. De Clercq, O. Bidet, J. Balzarini, 2003, Nucleosides, nucleotides & nucleic acids.

The in vitro and in vivo anti-retrovirus activity, and intracellular metabolism of 3'-azido-2',3'-dideoxythymidine and 2',3'-dideoxycytidine are highly dependent on the cell species.

E. De Clercq, R. Pauwels, P. Herdewijn, 1988, Biochemical pharmacology.

Unsaturated dideoxy fluoro-ketopyranosyl nucleosides as new cytostatic agents: a convenient synthesis of 2,6-dideoxy-3-fluoro-4-keto-beta-D-glucopyranosyl analogues of uracil, 5-fluorouracil, thymine, N4-benzoyl cytosine and N6-benzoyl adenine.

J. Balzarini, S. Manta, D. Komiotis, 2009, European journal of medicinal chemistry.

Dideoxy fluoro-ketopyranosyl nucleosides as potent antiviral agents: Synthesis and biological evaluation of 2,3- and 3,4-dideoxy-3-fluoro-4- and -2-keto-β-d-glucopyranosyl derivatives of N4-benzoyl cytosine

J. Balzarini, A. Cencič, S. Manta, 2009, European Journal of Medicinal Chemistry.

Structure‐Activity Relationship of Novel Oligopeptide Antiviral and Antitumor Agents Related to Netropsin and Distamycin.

J. Lown,, J. Balzarini, E. Clercq, 1986 .

Synthesis, Antiviral Evaluation, and Computational Studies of Cyclobutane and Cyclobutene L‐Nucleoside Analogues

Jean‐Didier Maréchal, J. Balzarini, M. Figueredo, 2013 .

Synthesis of 3'- and 5'-nitrooxy pyrimidine nucleoside nitrate esters: "nitric oxide donor" agents for evaluation as anticancer and antiviral agents.

E. De Clercq, J. Balzarini, Aihua Zhou, 2003, Journal of medicinal chemistry.

Acyclic nucleotide analogs derived from 8-azapurines: synthesis and antiviral activity.

E. De Clercq, J. Balzarini, G. Andrei, 1996, Journal of medicinal chemistry.

Synthesis, spectroscopic characterization, in vitro cytotoxic and structure activity relationships of some mononuclear Ru(II) complexes

J. Balzarini, E. Clercq, M. Imran, 2013 .

Synthesis, spectroscopic characterization and in vitro antitumor activities of some novel mononuclear Ru(II) complexes

J. Balzarini, E. Clercq, M. Imran, 2012 .

Synthesis and biological evaluation of a series of thieno-expanded tricyclic purine 2'-deoxy nucleoside analogues.

J. Balzarini, G. Andrei, R. Snoeck, 2012, Bioorganic & medicinal chemistry.

An epimer of 5'-noraristeromycin and its antiviral properties.

E. De Clercq, S. Ikeda, J. Balzarini, 1994, Journal of medicinal chemistry.

Synthesis and antiviral and cytostatic properties of 3'-deoxy-3'-fluoro- and 2'-azido-3'-fluoro-2',3'-dideoxy-D-ribofuranosides of natural heterocyclic bases.

E. De Clercq, J. Balzarini, N. Poopeiko, 1991, Journal of medicinal chemistry.

Investigations on the anti-HIV activity of 2',3'-dideoxyadenosine analogues with modifications in either the pentose or purine moiety. Potent and selective anti-HIV activity of 2,6-diaminopurine 2',3'-dideoxyriboside.

E. De Clercq, R. Pauwels, P. Herdewijn, 1988, Biochemical pharmacology.

Synthesis and biological activity of 3'-azido- and 3'-amino substituted nucleoside analogs

P. Herdewijn, J. Balzarini, E. Clercq, 1985 .

Antiviral, antimetabolic and antineoplastic activities of 2'- or 3'-amino or -azido-substituted deoxyribonucleosides.

E. De Clercq, J. Balzarini, J. Descamps, 1980, Biochemical pharmacology.

The Synthesis, Fluorescence and Antiviral Studies of 3′-Amino-2′,3′-Dideoxythymidine/substituted 10-Cyano-9-isothiocyanatoanthracene Adducts

J. Balzarini, E. Clercq, E. Biehl, 1994 .

Synthesis and anti-HIV activity of various 2'- and 3'-substituted 2',3'-dideoxyadenosines: a structure-activity analysis.

E. De Clercq, R. Pauwels, P. Herdewijn, 1987, Journal of medicinal chemistry.

Sensitive and rapid assay on MT-4 cells for detection of antiviral compounds against the AIDS virus.

E. De Clercq, R. Pauwels, P. Herdewijn, 1987, Journal of virological methods.

The 2',3'-dideoxyriboside of 2,6-diaminopurine selectively inhibits human immunodeficiency virus (HIV) replication in vitro.

E. De Clercq, R. Pauwels, P. Herdewijn, 1987, Biochemical and biophysical research communications.

Inactivation of S-adenosyl-L-homocysteine hydrolase and antiviral activity with 5',5',6',6'-tetradehydro-6'-deoxy-6'-halohomoadenosine analogues (4'-haloacetylene analogues derived from adenosine).

E. De Clercq, R. Borchardt, J. Balzarini, 1998, Journal of medicinal chemistry.

Cyclopentene carbocyclic nucleosides related to the antitumor nucleoside clitocine and their conversion to 8-aza-neplanocin analogues. Synthesis and antiviral activity

S. Ikeda, J. Balzarini, G. Andrei, 1993 .

Tuning efficiency of the 4-exo-trig cyclization by the electronic effect: ring closure of 3,3-difluoro-4-pentenyl carbon radicals and synthesis of a gem-difluorocyclobutane nucleoside.

Mika Ito, M. Baba, J. Balzarini, 2012, Chemical communications.

Synthesis and biological evaluation of phosphoramidate prodrugs of two analogues of 2-deoxy-d-ribose-1-phosphate directed to the discovery of two carbasugars as new potential anti-HIV leads

J. Balzarini, C. Mcguigan, N. Hamon, 2014, Bioorganic & Medicinal Chemistry.

Design, Synthesis, and Biological Evaluation of Unconventional Aminopyrimidine, Aminopurine, and Amino‐1,3,5‐triazine Methyloxynucleosides

Jan Balzarini, Gloria Fernández‐Cureses, Sonia de Castro, 2015, ChemMedChem.

Synthesis of Phosphonate Analogues of 2‐Deoxyribose‐1‐phosphate.

J. Balzarini, M. Camarasa, M. Pérez-Pérez, 1998 .

Synthesis and antiviral activity of 3'-C-branched-3'-deoxy analogues of adenosine.

T. M. Tsvetkova, E. De Clercq, J. Balzarini, 1996, Carbohydrate research.

Synthesis and biological evaluation of prodrugs of 2-fluoro-2-deoxyribose-1-phosphate and 2,2-difluoro-2-deoxyribose-1-phosphate

J. Balzarini, C. Mcguigan, N. Hamon, 2013, Bioorganic & Medicinal Chemistry Letters.

Inhibition of pyrimidine and purine nucleoside phosphorylases by a 3,5-dichlorobenzoyl-substituted 2-deoxy-D-ribose-1-phosphate derivative.

J. Balzarini, S. Liekens, C. Mcguigan, 2012, Biochemical pharmacology.

Synthesis and evaluation of novel amidate prodrugs of PMEA and PMPA.

E. De Clercq, J. Balzarini, C. Mcguigan, 2001, Bioorganic & medicinal chemistry letters.

SYNTHESIS AND IN VITRO CYTOTOXIC AND ANTIVIRAL ACTIVITIES OF 1-(2,5,6-TRIDEOXY-6-HALOGENOHEPT-5-ENOFURANURONONITRILE)THYMINE AND DERIVATIVES

E. De Clercq, J. Tronchet, M. Seman, 2002, Nucleosides, nucleotides & nucleic acids.

Cyclic saligenyl phosphotriesters of 2′,3′-dideoxy-2′,3′-didehydrothymidine (d4T) — a new pro-nucleotide approach

J. Balzarini, M. Lorey, E. D. Clercq, 1997 .

The novel L- and D-amino acid derivatives of hydroxyurea and hydantoins: synthesis, X-ray crystal structure study, and cytostatic and antiviral activity evaluations.

E. De Clercq, K. Pavelić, M. Kralj, 2005, Journal of medicinal chemistry.

Synthesis of (Z) and (E) α-Alkenyl Phosphonic Acid Derivatives of Purines and Pyrimidines.

C. Pannecouque, J. Balzarini, E. Clercq, 1998 .

Synthesis and antiviral evaluation of bis(POM) prodrugs of (E)-[4'-phosphono-but-2'-en-1'-yl]purine nucleosides.

J. Balzarini, G. Andrei, M. Hamada, 2012, European journal of medicinal chemistry.

Biological Activity of Some Dialkyl α-Anilinobenzylphosphonates and Their Palladium(II) Complexes

J. Balzarini, E. Clercq, L. Tušek-Boz̆ić, 1995 .

Spectroscopic and biological properties of palladium(II) complexes of ethyl 2-quinolylmethylphosphonate.

E. De Clercq, J. Balzarini, L. Tušek-Boz̆ić, 1998, Journal of inorganic biochemistry.

Nonnucleoside HIV-1 reverse transcriptase inhibitors: Part I. Synthesis and structure-activity relationship of 1-alkoxymethyl-5-alkyl-6-naphthylmethyl uracils as HEPT analogues.

E. De Clercq, C. Pannecouque, J. Balzarini, 2003, Chemical & pharmaceutical bulletin.

Homo Dinucleoside-α-hydroxyphosphonate Diesters as Prodrugs of the Antiviral Nucleoside Analogues 2′,3′-Dideoxythymidine and 3′-Azido-2′,3′-dideoxythymidine

J. Balzarini, E. Clercq, C. Meier, 1995 .

SRR-SB3, a disulfide-containing macrolide that inhibits a late stage of the replicative cycle of human immunodeficiency virus

E. De Clercq, C. Pannecouque, A. Vandamme, 1997, Antimicrobial agents and chemotherapy.

Thiosugars. X. Novel Nucleoside Analogues Derived from 4-Thio-L-lyxofuranose

E. De Clercq, J. Balzarini, J. Wirsching, 2003, Nucleosides, nucleotides & nucleic acids.

THIOSUGARS. VIII.* PREPARATION OF NEW 4′-THIO-L-LYXO PYRIMIDINE NUCLEOSIDE ANALOGUES

J. Balzarini, E. Clercq, J. Wirsching, 2001, Nucleosides, nucleotides & nucleic acids.

Thiosugars. Part 5: synthesis and biological activity of 1-(4-thio-L-arabinofuranosyl)-5-halopyrimidine nucleosides.

E. De Clercq, J. Balzarini, J. Wirsching, 2000, Bioorganic & medicinal chemistry letters.

Synthesis of 2-carbamoylmethyl-6-β-D-ribofuranosylpyridine with the aid of a Pd(0)-catalyzed reaction†

J. Balzarini, E. Clercq, E. Esmans, 1993 .

A mercapto analogue of 5'-noraristeromycin.

E. De Clercq, J. Balzarini, Subha R. Das, 2002, Bioorganic & medicinal chemistry.

Preparation of Chloro and Sulfanyl Derivatives of 1-(2-Deoxy-4-C-hydroxymethyl-α-L-threo-Pentofuranosyl)uracil

J. Balzarini, A. Holý, H. Hřebabecký, 1997 .

Tetrameric 1:1 and monomeric 1:3 complexes of silver(I) halides with tri( p -tolyl)-phosphine: A structural and biological study

Jan Balzarini, Ian S. Butler, Maciej Kubicki, 2009 .

E,E,E-1-(4-Arylamino-4-oxo-2-butenoyl)-3,5-bis(arylidene)-4-piperidones: a topographical study of some novel potent cytotoxins.

J. Dimmock, V. S. Parmar, A. Jha, 2007, Bioorganic & medicinal chemistry.

Intracellular Trapping of cyclo Sal-Pronucleotides : Modification of Prodrugs with Amino Acid Esters

J. Balzarini, C. Meier, H. Jessen, 2008 .

ThecycloSal-Nucleotide Delivery System

J. Balzarini, C. Meier, A. Meerbach, 2006 .

Aryl-Substituted and Benzo-Annulated CycloSal-Derivatives of 2′,3′-Dideoxy-2′,3′-Didehydrothymidine Monophosphate — Correlation of Structure, Hydrolysis Properties and Anti-HIV Activity

E. De Clercq, L. Naesens, J. Balzarini, 2002, Antiviral chemistry & chemotherapy.

SYNTHESIS AND ANTI-HIV ACTIVITY OF THYMIDINE ANALOGUES BEARING A 4′-CYANOVINYL GROUP AND SOME DERIVATIVES THEREOF

E. De Clercq, J. Tronchet, M. Seman, 2001, Nucleosides, nucleotides & nucleic acids.

First synthesis and evaluation of the inhibitory effects of aza analogues of TSAO on HIV-1 replication.

E. De Clercq, C. Pannecouque, C. Len, 2005, Journal of medicinal chemistry.

Design, synthesis and antiproliferative activity of some 3-benzylidene-2,3-dihydro-1-benzopyran-4-ones which display selective toxicity for malignant cells.

E. De Clercq, J. Dimmock, T. Lóránd, 2008, European journal of medicinal chemistry.

Synthesis and SAR of 2',3'-bis-O-substituted N(6), 5'-bis-ureidoadenosine derivatives: implications for prodrug delivery and mechanism of action.

J. Balzarini, J. Shelton, M. A. Peterson, 2012, Bioorganic & medicinal chemistry letters.

The synthesis and biological properties of some aryl bis(nucleosid-5'-YL) phosphates using nucleosides with proven anti-HIV activity

R. T. Walker, J. Balzarini, E. Clercq, 1992 .

Anti-HIV-1 activity of a tripodal receptor that recognizes mannose oligomers.

Y. Pommier, J. Balzarini, S. Noppen, 2015, European journal of medicinal chemistry.

Synthesis and anti‐HIV Activity of Thymidine Analogues Bearing a 4′‐Cyanovinyl Group and Some Derivatives Thereof.

J. Tronchet, M. Seman, J. Balzarini, 2002 .

Crystal Structure of (S)-1-Phenylethylammonium (R)-Mandelate and a Comparison of Diastereomeric Mandelate Salts of 1-Phenylethylamine.

U. Ragnarsson, J. Balzarini, E. Clercq, 1994 .

Synthesis of Heterocyclic Triterpene Derivatives with Biological Activities via Click Reaction

W. Dehaen, J. Balzarini, Thuc Dinh Ngoc, 2020 .

Synthesis and antiviral evaluation of cyclic and acyclic 2-methyl-3-hydroxy-4-pyridinone nucleoside derivatives.

E. De Clercq, J. Neyts, J. Balzarini, 2006, Journal of medicinal chemistry.

5-(1-Acetoxyvinyl)-cycloSaligenyl-2',3'-dideoxy-2',3'- didehydrothymidine monophosphates, a second type of new, enzymatically activated cycloSaligenyl pronucleotides.

J. Balzarini, N. Gisch, C. Meier, 2008, Journal of medicinal chemistry.

Antiviral Activity of Cyclosaligenyl Prodrugs of Acyclovir, Carbovir and Abacavir

E. De Clercq, J. Balzarini, C. Meier, 2001, Antiviral chemistry & chemotherapy.

Cyclosaligenyl-2',3'-didehydro-2',3'-dideoxythymidine monophosphate: efficient intracellular delivery of d4TMP.

E. De Clercq, J. Balzarini, E. Clercq, 2000, Molecular pharmacology.

Intracellular metabolism of CycloSaligenyl 3'-azido-2', 3'-dideoxythymidine monophosphate, a prodrug of 3'-azido-2', 3'-dideoxythymidine (zidovudine).

E. De Clercq, L. Naesens, C. Perno, 1999, Molecular pharmacology.

Characterization of the activation pathway of phosphoramidate triester prodrugs of stavudine and zidovudine.

E. De Clercq, L. Naesens, J. Balzarini, 1999, Molecular pharmacology.

ADA-Bypass by lipophilic cycloSal-ddAMP pro-nucleotides A second example of the efficiency of the cycloSal-Concept

J. Balzarini, E. Clercq, C. Meier, 1997 .

Differential patterns of intracellular metabolism of 2',3'-didehydro-2',3'-dideoxythymidine and 3'-azido-2',3'-dideoxythymidine, two potent anti-human immunodeficiency virus compounds.

E. De Clercq, P. Herdewijn, J. Balzarini, 1989, The Journal of biological chemistry.

"Lock-in"-cycloSal-pronucleotides - a new generation of chemical Trojan Horses?

J. Balzarini, C. Meier, D. Vukadinović, 2004, Mini reviews in medicinal chemistry.

Novel Nucleotide Analogues as Potential Substrates for TMPK, a Key Enzyme in the Metabolism of AZT

J. Reinstein, J. Balzarini, C. Meier, 2003, Nucleosides, nucleotides & nucleic acids.

cycloSal-d4TMP pronucleotides structural variations, mechanistic insights and antiviral activity.

J. Balzarini, C. Ducho, C. Meiera, 2002, Current topics in medicinal chemistry.

Synthesis and Antiviral Evaluation of Phosphoramidate Derivatives of (E)-5-(2-Bromovinyl)-2′-Deoxyuridine

E. De Clercq, J. Balzarini, C. Mcguigan, 2001, Antiviral chemistry & chemotherapy.

CycloSal-2'-ara(ribo)-fluoro-2',3'-dideoxyadenosine monophosphates--an effort to solve the structure-activity relationship of 2'-fluoro-ddA.

E. De Clercq, J. Balzarini, V. Marquez, 1999, Nucleosides & nucleotides.

Cyclic Saligenyl Phosphotriesters of 2′,3′-Dideoxy-2′,3′- didehydrothymidine (d4T) - A New Pro-Nucleotide Approach.

J. Balzarini, M. Lorey, E. D. Clercq, 1997 .

Design, synthesis and biological evaluation of novel nucleotide prodrugs as inhibitors of HIV replication

J. Balzarini, A. Karlsson, H. Egberink, 1997 .

Phosphoramidate derivatives of 2′,3′-didehydro-2′,3′-dideoxyadenosine [d4A] have markedly improved anti-HIV potency and selectivity

J. Balzarini, E. Clercq, C. Mcguigan, 1996 .

5′,5′-Di-O-nucleosyl-O′-benzylphosphotriesters as Potential Prodrugs of 3′-Azido-2′,3′-dideoxythymidine-5′-monophosphate.

J. Balzarini, E. D. Clercq, C. Meier, 1996 .

Synthesis and biological properties of novel phosphotriesters: a new approach to the introduction of biologically active nucleotides into cells.

R. T. Walker, E. De Clercq, J. Balzarini, 1990, Journal of medicinal chemistry.

Lipophilic prodrugs of nucleoside triphosphates as biochemical probes and potential antivirals

J. Balzarini, D. Schols, C. Meier, 2015, Nature Communications.

Esterase-cleavable cyclo Sal-pronucleotides – the trapping concept

J. Balzarini, C. Ducho, C. Meier, 2005 .

Interaction of cycloSal-pronucleotides with cholinesterases from different origins. A structure-activity relationship.

R. Esnouf, J. Balzarini, C. Ducho, 2004, Journal of medicinal chemistry.

2',3'-Dideoxynucleoside analogues as anti-HIV agents

P. Herdewijn, J. Balzarini, E. Clercq, 1993 .

Synthesis, in vitro antiviral evaluation, and stability studies of novel alpha-borano-nucleotide analogues of 9-[2-(phosphonomethoxy)ethyl]adenine and (R)-9-[2-(phosphonomethoxy)propyl]adenine.

J. Neyts, J. Balzarini, B. Canard, 2006, Journal of medicinal chemistry.

N(4)-Acyl derivatives as lipophilic prodrugs of cidofovir and its 5-azacytosine analogue, (S)-HPMP-5-azaC: chemistry and antiviral activity.

R. Pohl, J. Balzarini, G. Andrei, 2014, Bioorganic & medicinal chemistry.

Synthesis, Characterization and in Vitro Study of the Cytostatic and Antiviral Activity of New Polymeric Silver(I) Complexes with Ribbon Structures Derived from the Conjugated Heterocyclic Thioamide 2-Mercapto-3,4,5,6-tetra- hydropyrimidine

Jan Balzarini, Erik De Clercq, A. Michaelides, 2004 .

Synthesis and in vitro activity of novel N-3 acylated TSAO-T compounds against HIV-1 and HCV.

G. Duverlie, S. Castelain, J. Balzarini, 2011, European journal of medicinal chemistry.

Synthesis and in vitro activity of novel N- 3 acylated TSAO-T compounds against HIV-1 and HCV European Journal of Medicinal Chemistry

G. Duverlie, S. Castelain, J. Balzarini, 2011 .

Synthesis and anti-HIV1 biological activity of novel 5''-ATSAO compounds.

E. De Clercq, C. Pannecouque, J. Balzarini, 2008, Bioorganic & medicinal chemistry.

Synthesis, anti-HIV-1 activity, and modeling studies of N-3 Boc TSAO compound.

E. De Clercq, C. Pannecouque, J. Balzarini, 2008, Bioorganic & medicinal chemistry letters.

New neplanocin analogues. 7. Synthesis and antiviral activity of 2-halo derivatives of neplanocin A.

E. De Clercq, S. Shuto, A. Matsuda, 1996, Journal of medicinal chemistry.

New neplanocin analogues. 1. Synthesis of 6'-modified neplanocin A derivatives as broad-spectrum antiviral agents.

E. De Clercq, S. Shuto, M. Hosoya, 1992, Journal of medicinal chemistry.

Synthesis and anti-HIV properties of 1,2,4,6-thiatriazin-3-one 1,1-dioxide nucleosides.

E. De Clercq, J. Balzarini, M. Jimeno, 1998, Nucleosides & nucleotides.

Comparative inhibitory effects of suramin and other selected compounds on the infectivity and replication of human T‐cell lymphotropic virus (HTLV‐III)/lymphadenopathy‐associated virus (LAV)

E. De Clercq, H. Mitsuya, S. Broder, 1986, International journal of cancer.

Novel adamantylated pyrimidines and their preliminary biological evaluations.

J. Balzarini, A. Laudy, B. Starościak, 2004, Farmaco.

Mechanism of anti-human immunodeficiency virus action of polyoxometalates, a class of broad-spectrum antiviral agents.

E. De Clercq, R. Pauwels, M. Hosoya, 1992, Molecular pharmacology.

Improving the antiviral efficacy and selectivity of HIV-1 reverse transcriptase inhibitor TSAO-T by the introduction of functional groups at the N-3 position.

E. De Clercq, F. Gago, J. Balzarini, 2005, Journal of medicinal chemistry.

Synthests and Biological Evaluation of a Series of Substituted-2-Pyridine-C-Nucleosides. Part II

J. Balzarini, R. Dommisse, E. Esmans, 1986 .

Cytotoxic 5-aryl-1-(4-nitrophenyl)-3-oxo-1,4-pentadienes mounted on alicyclic scaffolds.

E. De Clercq, J. Dimmock, Rajendra K. Sharma, 2006, European journal of medicinal chemistry.

Cytotoxic Mannich Bases of 1-Arylidene-2-tetralones

E. De Clercq, R. Sharma, J. Dimmock, 2003, Journal of enzyme inhibition and medicinal chemistry.

Correlations between cytotoxicity and topography of some 2-arylidenebenzocycloalkanones determined by X-ray crystallography.

E. De Clercq, J. Quail, J. Dimmock, 2002, Journal of medicinal chemistry.

Conformational and quantitative structure-activity relationship study of cytotoxic 2-arylidenebenzocycloalkanones.

L. Prasad, E. De Clercq, J. Quail, 1999, Journal of medicinal chemistry.

Crystal Structure of a Carbonylation Catalyst: Acetyldiiodo-1,3-bis(diphenylphosphino)propanerhodium(III).

D. Aksnes, U. Ragnarsson, J. Balzarini, 1994 .

The role of cellular oxidoreductases in viral entry and virus infection-associated oxidative stress: potential therapeutic applications

J. Balzarini, Leen Mathys, 2016, Expert opinion on therapeutic targets.

2-Aminopyrimidine based 4-aminoquinoline anti-plasmodial agents. Synthesis, biological activity, structure–activity relationship and mode of action studies

K. Chibale, J. Balzarini, H. Kaur, 2012, European Journal of Medicinal Chemistry.

3'-C-branched 2'-deoxy-5-methyluridines: synthesis, enzyme inhibition, and antiviral properties.

E. De Clercq, M. Kukhanova, J. Balzarini, 1992, Journal of medicinal chemistry.

Correction: Facile functionalization at the C4 position of pyrimidine nucleosides via amide group activation with (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) and biological evaluations of the products.

J. Balzarini, D. Schols, G. Andrei, 2017, Organic & biomolecular chemistry.

Palladium‐Catalyzed Aryl Amination Reactions of 6‐Bromo‐ and 6‐Chloropurine Nucleosides

J. Balzarini, Erik de Clercq, M. Lakshman, 2010, Advanced synthesis & catalysis.

Evaluation of the semicarbazones, thiosemicarbazones and bis-carbohydrazones of some aryl alicycylic ketones for anticonvulsant and other biological propertie

J. Quail, J. Dimmock, J. Balzarini, 1995 .

Design, Synthesis and Evaluation of Antiproliferative Activity of New Benzimidazolehydrazones

G. Balboni, J. Balzarini, S. Liekens, 2016, Molecules.

Synthesis, Cytostatic and Antiviral Activity of Some Ruthenium (II) Complexes

J. Balzarini, E. Clercq, Sujeet Kumar, 2014 .

Novel linked antiviral and antitumor agents related to netropsin and distamycin: synthesis and biological evaluation.

E. De Clercq, J. Lown,, R. Newman, 1989, Journal of medicinal chemistry.

Phosphonylmethoxyalkyl derivatives of purines and pyrimides: A new class of antiviral agents active against both herpesviruses and retroviruses☆

R. Pauwels, M. Baba, J. Balzarini, 1987 .

Design, synthesis and biological evaluation of 2-alkoxycarbonyl-3-anilinoindoles as a new class of potent inhibitors of tubulin polymerization.

A. Brancale, G. Viola, Roberta Bortolozzi, 2020, Bioorganic chemistry.

Studies of Phase Equilibria in the System MgO--Mo--O in the Temperature Range 1100--1400 K.

U. Ragnarsson, J. Balzarini, E. Clercq, 1994 .

Thymidylate synthetase‐positive and ‐negative murine mammary FM3A carcinoma cells as a useful system for detecting thymidylate synthetase inhibitors

E. De Clercq, T. Seno, D. Ayusawa, 1984, FEBS letters.

High mannose-specific lectin Msl mediates key interactions of the vaginal Lactobacillus plantarum isolate CMPG5300

S. Lebeer, J. Vanderleyden, J. Balzarini, 2016, Scientific Reports.

Cloning and characterization of the lectin cDNA clones from onion, shallot and leek

I. Goldstein, F. Leuven, J. Balzarini, 1993, Plant Molecular Biology.

Synthesis of 5-Amino-3,3-dimethyl-7-phenyl-3H-[1,2]oxathiolo [4,3-b]pyridine-6-carbonitrile 1,1-Dioxides.

J. Balzarini, Abdelouahid Samadi, J. Marco-Contelles, 2014 .

Derive du glycinamide destine a inhiber la replication du vih

J. Balzarini, M. Högberg, Weimin Tong, 2004 .

Aurintricarboxylic acid and Evans Blue represent two different classes of anionic compounds which selectively inhibit the cytopathogenicity of human T-cell lymphotropic virus type III/lymphadenopathy-associated virus.

E. De Clercq, H. Mitsuya, S. Broder, 1986, Biochemical and biophysical research communications.

Thymidylate synthetase-deficient mouse FM3A mammary carcinoma cell line as a tool for studying the thymidine salvage pathway and the incorporation of thymidine analogues into host cell DNA.

E. De Clercq, T. Seno, D. Ayusawa, 1984, The Biochemical journal.

Role of thymidine kinase in the inhibitory activity of 5-substituted-2'-deoxyuridines on the growth of human and murine tumor cell lines.

R. T. Walker, E. De Clercq, P. Barr, 1982, Biochemical pharmacology.

Antiviral, antitumor, and thymidylate synthetase inhibition studies of 5-substituted styryl derivatives of 2'-deoxyuridine and their 5'-phosphates.

E. De Clercq, J. Balzarini, J. Descamps, 1981, Biochemical pharmacology.

Antiproliferative activity, mechanism of action and oral antitumor activity of CP-4126, a fatty acid derivative of gemcitabine, in in vitro and in vivo tumor models

G. Peters, I. Fichtner, A. Bergman, 2010, Investigational New Drugs.

A Multitarget Approach toward the Development of 8‐Substituted Purines for Photoprotection and Prevention of UV‐Related Damage

J. Balzarini, S. Liekens, S. Manfredini, 2017, ChemMedChem.

Novel In Vivo Model for the Study of Human Immunodeficiency Virus Type 1 Transcription Inhibitors: Evaluation of New 6-Desfluoroquinolone Derivatives

E. De Clercq, C. Pannecouque, E. Verbeken, 2007, Antimicrobial Agents and Chemotherapy.

2 A NOVEL IN VIVO MODEL FOR THE STUDY OF HIV-1 3 TRANSCRIPTION INHIBITORS : EVALUATION OF NEW 4 6-DESFLUOROQUINOLONE DERIVATIVES ( 6-DFQs ) 5

C. Pannecouque, E. Verbeken, J. Balzarini, 2007 .

HIV-1 transcription in vivo-1-1 2 A NOVEL IN VIVO MODEL FOR THE STUDY OF HIV-1 3 TRANSCRIPTION INHIBITORS : EVALUATION OF NEW 4 6-DESFLUOROQUINOLONE DERIVATIVES ( 6-DFQs ) 5 6 7

C. Pannecouque, E. Verbeken, J. Balzarini, 2007 .

Insecticidal activity of the pyrimidine nucleoside analogue (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU).

J. Balzarini, A. De Loof, M. Breuer, 2005, Pest management science.

Novel bicyclic sugar modified nucleosides: synthesis, conformational analysis and antiviral evaluation.

E. De Clercq, N. Kifli, J. Balzarini, 2004, Bioorganic & medicinal chemistry.

The multifunctional deoxynucleoside kinase of insect cells is a target for the development of new insecticides.

E. De Clercq, B. Degrève, J. Balzarini, 2000, Molecular pharmacology.

Arylazolylthioacetanilide. Part 11: design, synthesis and biological evaluation of 1,2,4-triazole thioacetanilide derivatives as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.

C. Pannecouque, P. Zhan, Xinyong Liu, 2013, Medicinal chemistry (Shariqah (United Arab Emirates)).

Arylazolyl(azinyl)thioacetanilides. Part 10: design, synthesis and biological evaluation of novel substituted imidazopyridinylthioacetanilides as potent HIV-1 inhibitors.

Peng Zhan, Jan Balzarini, Xuwang Chen, 2012, Bioorganic & medicinal chemistry.

In Vitro Evaluation of Nonnucleoside Reverse Transcriptase Inhibitors UC-781 and TMC120-R147681 as Human Immunodeficiency Virus Microbicides

Jan Balzarini, Luc Kestens, Katrien Fransen, 2004, Antimicrobial Agents and Chemotherapy.

Identification of novel thiocarboxanilide derivatives that suppress a variety of drug-resistant mutant human immunodeficiency virus type 1 strains at a potency similar to that for wild-type virus

E. De Clercq, J. Balzarini, D. C. Dao, 1996, Antimicrobial agents and chemotherapy.

Antitumor activity of P-4055 (elaidic acid-cytarabine) compared to cytarabine in metastatic and s.c. human tumor xenograft models.

E. De Clercq, O. Fodstad, J. Balzarini, 1999, Cancer research.

Topical tenofovir, a microbicide effective against HIV, inhibits herpes simplex virus-2 replication.

J. J. van den Oord, L. Margolis, J. Balzarini, 2011, Cell host & microbe.

KAY-2-41, a Novel Nucleoside Analogue Inhibitor of Orthopoxviruses In Vitro and In Vivo

J. J. van den Oord, J. Balzarini, G. Andrei, 2013, Antimicrobial Agents and Chemotherapy.

In vivo antiviral activity of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine and its cyclic form

L. Naesens, J. Neyts, J. Balzarini, 2007 .

Antiviral Activity of Triazine Analogues of 1-(S)-[3-Hydroxy-2-(phosphonomethoxy)propyl]cytosine (Cidofovir) and Related Compounds

Lieve Naesens, Jan Balzarini, Erik De Clercq, 2007 .

6‐[2‐Phosphonomethoxy)Alkoxy]‐2,4‐Diaminopyrimidines: A New Class of Acyclic Pyrimidine Nucleoside Phosphonates with Antiviral Activity

E. De Clercq, C. Pannecouque, L. Naesens, 2004, Nucleosides, nucleotides & nucleic acids.

Sulphated Polymers are Potent and Selective Inhibitors of Various Enveloped Viruses, Including Herpes Simplex Virus, Cytomegalovirus, Vesicular Stomatitis Virus, Respiratory Syncytial Virus, and Toga-, Arena- and Retroviruses

E. De Clercq, R. Pauwels, M. Hosoya, 1990 .

Acyclovir is activated into a HIV-1 reverse transcriptase inhibitor in herpesvirus-infected human tissues.

R. Schinazi, R. Gorelick, J. Grivel, 2008, Cell host & microbe.

Synthesis of penicillamine- and cysteine-containing nucleoamino acids as potential antivirals and aminopeptidase B inhibitors

M. García-López, J. Balzarini, E. Clercq, 1991 .

The N-7-substituted acyclic nucleoside analog 2-amino-7-[(1,3-dihydroxy-2-propoxy)methyl]purine is a potent and selective inhibitor of herpesvirus replication

E. De Clercq, J. Neyts, J. Balzarini, 1994, Antimicrobial Agents and Chemotherapy.

Microbicide drug candidates to prevent HIV infection

J. Balzarini, L. V. Damme, L. Damme, 2007, The Lancet.

Novel 1,1,3-trioxo-2H,4H-thieno[3,4-e][1,2,4]thiadiazine derivatives as non-nucleoside reverse transcriptase inhibitors that inhibit human immunodeficiency virus type 1 replication.

E. De Clercq, C. Pannecouque, J. Balzarini, 1998, Journal of medicinal chemistry.

Mycoplasmas and cancer: focus on nucleoside metabolism

J. Balzarini, S. Liekens, J. Vande Voorde, 2014, EXCLI journal.

Mycoplasmas and cancer

J. Balzarini, S. Liekens, J. Voorde, 2014 .

Mycoplasma hyorhinis–Encoded Purine Nucleoside Phosphorylase: Kinetic Properties and Its Effect on the Cytostatic Potential of Purine-Based Anticancer Drugs

J. Balzarini, S. Liekens, J. Vande Voorde, 2013, Molecular Pharmacology.

Vaginal microbiota and its role in HIV transmission and infection.

S. Lebeer, J. Vanderleyden, J. Balzarini, 2013, FEMS microbiology reviews.

Synthesis, antimycobacterial, antiviral, antimicrobial activities, and QSAR studies of isonicotinic acid-1-(substituted phenyl)-ethylidene/cycloheptylidene hydrazides

B. Narasimhan, P. Yogeeswari, D. Sriram, 2012, Medicinal Chemistry Research.

Inhibition of visna virus replication and cytopathic effect in sheep choroid plexus cell cultures by selected anti-HIV agents.

E. De Clercq, J. Balzarini, Z. Debyser, 1995, Antiviral research.

Broad Antiviral Activity of Carbohydrate-Binding Agents against the Four Serotypes of Dengue Virus in Monocyte-Derived Dendritic Cells

J. Neyts, J. Balzarini, D. Schols, 2011, PloS one.

3′‐(1,2,3‐Triazol‐1‐yl)‐2′,3′‐dideoxythymidine and 3′‐(1,2,3‐triazol‐1‐yl)‐2′,3′‐dideoxyuridine

P. Herdewijn, A. Aerschot, J. Balzarini, 2009 .

Visna in sheep as a model for chemotherapy of lentiviral central nervous system infections.

L. Naesens, G. Georgsson, J. Balzarini, 1998, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.

Acyclic purine nucleoside phosphonates as retrovirus inhibitors

J. Balzarini, E. Clercq, 1995 .

Inhibition of visna virus replication by 2',3'-dideoxynucleosides and acyclic nucleoside phosphonate analogs

E. De Clercq, J. Balzarini, Z. Debyser, 1993, Antimicrobial Agents and Chemotherapy.

The mannose-specific plant lectins from Cymbidium hybrid and Epipactis helleborine and the (N-acetylglucosamine)n-specific plant lectin from Urtica dioica are potent and selective inhibitors of human immunodeficiency virus and cytomegalovirus replication in vitro.

E. De Clercq, M. Hosoya, J. Neyts, 1992, Antiviral research.

Pentosan polysulfate, a sulfated oligosaccharide, is a potent and selective anti-HIV agent in vitro.

E. De Clercq, R. Pauwels, M. Nakajima, 1988, Antiviral research.

The Novel [4,5-e][1,3]Diazepine-4,8-dione and Acyclic Carbamoyl Imino-Ureido Derivatives of Imidazole: Synthesis, Anti-Viral and Anti-Tumor Activity Evaluations

K. Pavelić, J. Plavec, J. Balzarini, 2013, Molecules.

ACYCLIC/CARBOCYCLIC GUANOSINE ANALOGUES AS ANTI-HERPESVIRUS AGENTS

P Leyssen, E. De Clercq, L. Naesens, 2001, Nucleosides, nucleotides & nucleic acids.

3,5-Di-(tert-Butyl)-6-fluoro-cycloSal-d4TMP − A Pronucleotide with a Considerably Improved Masking Group

J. Balzarini, C. Ducho, C. Meier, 2003 .

Cell-dependent interference of a series of new 6-aminoquinolone derivatives with viral (HIV/CMV) transactivation.

E. De Clercq, C. Pannecouque, J. Balzarini, 2005, The Journal of antimicrobial chemotherapy.

E. De Clercq, J. Balzarini, P. Hatfield, 1984, Journal of medicinal chemistry.

Synthesis and biological activity of tricyclic analogues of 9-[[cis-1',2'-bis(hydroxymethyl)cycloprop-1'-yl]methyl]guanine.

E. De Clercq, J. Balzarini, B. Golankiewicz, 2006, Bioorganic & medicinal chemistry.

The novel pyrimidine and purine derivatives of l-ascorbic acid: synthesis, one- and two-dimensional 1H and 13C NMR study, cytostatic and antiviral evaluation.

E. De Clercq, K. Pavelić, J. Plavec, 2005, Bioorganic & medicinal chemistry.

Synthesis and antiproliferative activity of 2′-O-allyl-1-β-D-arabinofuranosyl-uracil, -cytosine and -adenine

J. Balzarini, E. Clercq, S. Manfredini, 1997 .

Novel selective human mitochondrial kinase inhibitors: design, synthesis and enzymatic activity.

Ann Saada, J. Balzarini, A. Karlsson, 2007, Bioorganic & medicinal chemistry.

Synthesis, anticancer, and cytotoxic activities of some mononuclear Ru(II) compounds.

E. De Clercq, J. Balzarini, S. Karki, 2007, Bioorganic & medicinal chemistry.

Synthesis, antineoplastic and cytotoxic activities of some mononuclear Ru(II) complexes

J. Balzarini, E. Clercq, S. Karki, 2010, Journal of enzyme inhibition and medicinal chemistry.

Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket.

A. D. Clark, E. Arnold, K. Das, 2011, Journal of medicinal chemistry.

Antiviral Activity of N4-Aminocytidine Derivatives Related to AZT

E. De Clercq, J. Balzarini, D. Loakes, 1995 .

Synthesis and cytotoxic activity of 6-vinyl- and 6-ethynyluridine and 8-vinyl-and 8-ethynyladenosine.

E. De Clercq, J. Balzarini, S. Manfredini, 1995, Journal of medicinal chemistry.

Human immunodeficiency virus type 1 drug-resistance patterns with different 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine derivatives.

E. De Clercq, J. Balzarini, A. Karlsson, 1993, Molecular pharmacology.

Nonnucleoside HIV-1 reverse-transcriptase inhibitors, part 5. Synthesis and anti-HIV-1 activity of novel 6-naphthylthio HEPT analogues.

E. De Clercq, C. Pannecouque, J. Balzarini, 2005, Chemical & pharmaceutical bulletin.

Synthesis, Biological Activity, Pharmacokinetic Properties and Molecular Modelling Studies of Novel 1H,3H-Oxazolo[3,4-a]Benzimidazoles: Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors

E. De Clercq, C. Pannecouque, G. De Sarro, 2001, Antiviral chemistry & chemotherapy.

Synthesis and biological evaluation of dinucleoside methylphosphonates of 3'-azido-3'-deoxythymidine and 2', 3'-dideoxycytidine.

E. De Clercq, J. Balzarini, E. Clercq, 1990, Antiviral research.

Role of antimetabolites of purine and pyrimidine nucleotide metabolism in tumor cell differentiation.

E. De Clercq, J. Balzarini, E. Clercq, 1999, Biochemical pharmacology.

Mannose-Specific Plant Lectins from the Amaryllidaceae Family Qualify as Efficient Microbicides for Prevention of Human Immunodeficiency Virus Infection

E. De Clercq, J. Balzarini, D. Schols, 2004, Antimicrobial Agents and Chemotherapy.

Phosphonylmethoxyethyl purine derivatives, a new class of anti-human immunodeficiency virus agents

E. De Clercq, R. Pauwels, M. Baba, 1988, Antimicrobial Agents and Chemotherapy.

Novel DNA groove binding alkylators: design, synthesis, and biological evaluation.

E. De Clercq, J. Lown,, R. Newman, 1988, Journal of medicinal chemistry.

New neplanocin analogues. VIII. Synthesis and biological activity of 6'-C-ethyl, -ethenyl, and -ethynyl derivatives of neplanocin A.

E. De Clercq, S. Shuto, A. Matsuda, 1997, Chemical & pharmaceutical bulletin.

Homocysteine potentiates the antiviral and cytostatic activity of those nucleoside analogues that are targeted at S-adenosylhomocysteine hydrolase.

E. De Clercq, J. Balzarini, M. Cools, 1989, Biochemical pharmacology.

Synthesis, cytostatic activity and inhibition of ribonucleotide reductase by 5'-phosphoramidates and 5'-diphosphates, of 2'-O-allyl-arabinofuranosyl nucleosides.

E. De Clercq, J. Balzarini, A. Karlsson, 1999, Nucleosides & nucleotides.

Synthesis and Antiproliferative Activity of 2′‐O‐Allyl‐1‐β‐D‐ arabinofuranosyl‐uracil, ‐cytosine and ‐adenine.

J. Balzarini, E. Clercq, S. Manfredini, 1997 .

Synthesis, biological evaluation, and structure analysis of a series of new 1,5-anhydrohexitol nucleosides.

E. De Clercq, J. Rozenski, J. Balzarini, 1995, Journal of medicinal chemistry.

3'-Fluoro-2',3'-dideoxy-5-chlorouridine: most selective anti-HIV-1 agent among a series of new 2'- and 3'-fluorinated 2',3'-dideoxynucleoside analogues.

E. De Clercq, R. Pauwels, P. Herdewijn, 1989, Journal of medicinal chemistry.

Anti-retrovirus activity of 3'-fluoro- and 3'-azido-substituted pyrimidine 2',3'-dideoxynucleoside analogues.

R. Pauwels, P. Herdewijn, M. Baba, 1988, Biochemical pharmacology.

A two plasmid co-expression system in Escherichia coli for the production of virion-like reverse transcriptase of the human immunodeficiency virus type 1.

E. De Clercq, J. Vandekerckhove, J. Balzarini, 1996, Journal of virological methods.

J. Balzarini, E. Clercq, J. Imbach, 1988 .

Selective antiherpetic activity of carbocyclic analogues of (E)-5-(2-halogenovinyl)-2'-deoxyuridines: dependence on specific phosphorylation by viral thymidine kinase.

E. De Clercq, P. Herdewijn, A. Verbruggen, 1985, Biochemical and biophysical research communications.

Chemo-enzymatic Synthesis of 3-Deoxy-β-D-ribofuranosyl Purines and Study of Their Biological Properties

E. De Clercq, J. Balzarini, V. Barai, 2003, Nucleosides, nucleotides & nucleic acids.

Database Searching for Thymidine and Thymidylate Kinase Inhibitors Using Three-dimensional Structure-based Methods

M. Delarue, D. Manallack, E. De Clercq, 2002, Journal of enzyme inhibition and medicinal chemistry.

Synthesis and antiviral activity of 3'-heterocyclic substituted 3'-deoxythymidines.

E. De Clercq, P. Herdewijn, G. Janssen, 1990, Journal of medicinal chemistry.

5′-Nor Carbocyclic 5′-Deoxy-5′-(Isobutylthio)Adenosine and a 2′,3′-Dideoxy-2′,3′-Didehydro Derivative

E. De Clercq, J. Balzarini, Subha R. Das, 2001, Antiviral chemistry & chemotherapy.

Novel ribofuranosylnucleoside lead compounds for potent and selective inhibitors of mitochondrial thymidine kinase-2.

E. De Clercq, J. Balzarini, A. Karlsson, 2000, The Biochemical journal.

Effects of 2',3'-dideoxycytidine and 2',3'-dideoxycytidine 5'-triphosphate on phospholipid metabolism in permeabilized rat hepatocytes.

L. Naesens, J. Balzarini, P. Declercq, 1997, Biochemical pharmacology.

Anti-(herpes simplex virus) activity of 4'-thio-2'-deoxyuridines: a biochemical investigation for viral and cellular target enzymes.

R. T. Walker, E. De Clercq, J. Balzarini, 2000, The Biochemical journal.

Synthesis and anti-HIV-1 Activity of [1-[2′,5′-Bis-O-(Tert-Butyldimethylsilyl)-β-L-Ribofuranosyl]Thymine]-3′-Spiro-5″-(4″-Amino-1″,2″-Oxathiole-2″,2″-Dioxide) (L-TSAO-T), the L-enantiomer of the Highly Specific HIV-1 Reverse Transcriptase Inhibitor TSAO-T

E. De Clercq, J. Balzarini, M. Camarasa, 1995 .

Substrate specificity of vaccinia virus thymidylate kinase

S. Pochet, L. Dugué, B. Collinet, 2005, The FEBS journal.

Synthesis and Antiviral Activity of 3′‐Heterocyclic Substituted 3′‐Deoxythymidines.

P. Herdewijn, G. Janssen, A. Aerschot, 1990 .

Mechanisms underlying activity of antiretroviral drugs in HIV‐1‐infected macrophages: new therapeutic strategies

A. Antinori, J. Balzarini, D. Schols, 2006, Journal of leukocyte biology.

The regulation of HIV‐1 transcription: Molecular targets for chemotherapeutic intervention

E. De Clercq, J. Balzarini, M. Stevens, 2006, Medicinal research reviews.

Synthesis, antiviral and cytostatic activities of carbocyclic nucleosides incorporating a modified cyclopentane ring. Part 2: Adenosine and uridine analogues.

E. De Clercq, X. García‐Mera, J. Neyts, 1998, Nucleosides & nucleotides.

Synthesis, conformational analysis and antiviral and antitumoral activity of new 1,2-disubstituted carbocyclic nucleosides.

Jan Balzarini, Lourdes Santana, Marta Teijeira, 2002, European journal of medicinal chemistry.

Stereoselective facile synthesis of 2'-spiro pyrimidine pyranonucleosides via their key intermediate 2'-C-cyano analogues. Evaluation of their bioactivity.

J. Balzarini, A. Dimopoulou, S. Manta, 2014, Carbohydrate research.

Novel Non-Nucleoside Human Cytomegalovirus Inhibitors Based Upon Tsao Nucleoside Derivatives: Structure-Activity Relationships

J. Balzarini, M. Camarasa, S. Velázquez, 2007, Nucleosides, nucleotides & nucleic acids.

Novel [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]- 3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2" -dioxide) derivatives with anti-HIV-1 and anti-human-cytomegalovirus activity.

E. De Clercq, J. Balzarini, M. Camarasa, 2005, Journal of medicinal chemistry.

3'-Spiro nucleosides, a new class of specific human immunodeficiency virus type 1 inhibitors: synthesis and antiviral activity of [2'-5'-bis-O-(tert-butyldimethylsilyl)-beta-D-xylo- and -ribofuranose]-3'-spiro-5"-[4"-amino-1",2"-oxathiole 2",2"-dioxide] (TSAO) pyrimidine nucleosides.

E. De Clercq, J. Balzarini, E. Clercq, 1992, Journal of medicinal chemistry.

Novel series of TSAO-T derivatives. Synthesis and anti-HIV-1 activity of 4-, 5-, and 6-substituted pyrimidine analogues.

E. De Clercq, J. Balzarini, M. Camarasa, 1994, Journal of medicinal chemistry.

Antiviral enantiomeric preference for 5'-noraristeromycin.

E. De Clercq, S. Ikeda, J. Balzarini, 1994, Journal of medicinal chemistry.

Suppression of resistance to drugs targeted to human immunodeficiency virus reverse transcriptase by combination therapy.

J. Balzarini, 1999, Biochemical pharmacology.

Initial studies on the cellular pharmacology of 2',3-dideoxycytidine, an inhibitor of HTLV-III infectivity.

S. Broder, J. Balzarini, D. Cooney, 1986, Biochemical pharmacology.

Acyclic nucleoside phosphonates with a branched 2-(2-phosphonoethoxy)ethyl chain: Efficient synthesis and antiviral activity

J. Balzarini, G. Andrei, R. Snoeck, 2011, Bioorganic & Medicinal Chemistry.

Enhancement of natural killer activity and interferon induction by different acyclic nucleoside phosphonates.

E. De Clercq, C. Perno, J. Balzarini, 1994, Antiviral research.

Inhibitory effect of 9-(2-phosphonylmethoxyethyl)-adenine (PMEA) on human and duck hepatitis B virus infection.

E. De Clercq, J. Balzarini, A. Holý, 1993, Antiviral research.

Synthesis and antiviral properties of carbocyclic 3'-oxa-2',3'-dideoxyguanosine and its 7-deazaguanosine analogue.

E. De Clercq, J. Balzarini, S. Siddiqi, 1993, Antiviral research.

Synthesis and biological evaluation of 3'-C-ethynyl and 3'-C-(1,4-disubstituted-1,2,3-triazolo) double-headed pyranonucleosides.

J. Balzarini, S. Manta, E. Coutouli-argyropoulou, 2012, Medicinal chemistry (Shariqah (United Arab Emirates)).

Synthesis of 4'-Ethynyl-2'-deoxy-4'-thioribonucleosides and Discovery of a Highly Potent and Less Toxic NRTI.

M. Baba, J. Balzarini, H. Abe, 2011, ACS medicinal chemistry letters.

The Design, Synthesis and Antiviral Evaluation of a Series of 5-trimethylsilyl-1-β-d-(arabinofuranosyl) uracil phosphoramidate ProTides

J. Balzarini, C. Mcguigan, Y. Mehellou, 2010, Antiviral chemistry & chemotherapy.

Structure, physiological role, and specific inhibitors of human thymidine kinase 2 (TK2): Present and future

Jan Balzarini, Federico Gago, F. Gago, 2008, Medicinal research reviews.

Bromovinyl-deoxyuridine: A selective substrate for mitochondrial thymidine kinase in cell extracts.

J. Balzarini, V. Bianchi, M. Pérez-Pérez, 2006, Biochemical and biophysical research communications.

Mitochondrial thymidine kinase inhibitors.

F. Gago, J. Balzarini, M. Camarasa, 2005, Current topics in medicinal chemistry.

Synthesis and evaluation of thymine-derived carboxamides against mitochondrial thymidine kinase (TK-2) and related enzymes.

J. Balzarini, A. Karlsson, M. Camarasa, 2004, Bioorganic & medicinal chemistry.

Improving the selectivity of acyclic nucleoside analogues as inhibitors of human mitochondrial thymidine kinase: replacement of a triphenylmethoxy moiety with substituted amines and carboxamides.

F. Gago, J. Balzarini, A. Karlsson, 2003, Bioorganic & medicinal chemistry letters.

Non-nucleoside inhibitors of mitochondrial thymidine kinase (TK-2) differentially inhibit the closely related herpes simplex virus type 1 TK and Drosophila melanogaster multifunctional deoxynucleoside kinase.

R. Esnouf, P. Roche, J. Balzarini, 2003, Molecular pharmacology.

TSAO Analogues. Stereospecific Synthesis and Anti‐HIV‐1 Activity of 1‐( 2′,5′‐Bis‐O‐(tert‐butyldimethylsilyl)‐β‐D‐ribofuranosyl)‐3′‐spiro‐ 5′′‐(4′′‐amino‐1′′,2′′‐oxathiole 2′′,2′′‐dioxide)pyrimidine and Pyrimidine‐Modified Nucleosides.

J. Balzarini, E. Clercq, M. Camarasa, 1992 .

3′-Spiro Nucleosides, a New Class of Specific Human Immunodeficiency Virus Type 1 Inhibitors: Synthesis and Antiviral Activity of (2′,5′- Bis-O-(tert-butyldimethylsilyl)-β-D-xylo- and -ribofuranose)-3′- spiro-5′′-(4′′-amino-1′′,2′′-oxathiole 2′′,2′′-Dioxide) (TSAO) Pyrimidine Nucleosides.

J. Balzarini, E. Clercq, M. Camarasa, 1992 .

TSAO analogues. Stereospecific synthesis and anti-HIV-1 activity of 1-[2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]-3'-spiro -5''- (4''-amino-1'',2''-oxathiole 2'',2''-dioxide) pyrimidine and pyrimidine-modified nucleosides.

E. De Clercq, J. Balzarini, M. Camarasa, 1992, Journal of medicinal chemistry.

Hiv-1 Specific Reverse Transcriptase Inhibitors: why are Tsao-Nucleosides so Unique?

E. De Clercq, F. Gago, J. Balzarini, 2000 .

Novel L-lyxo and 5'-deoxy-5'-modified TSAO-T analogs: synthesis and anti-HIV-1 activity.

E. De Clercq, J. Balzarini, M. Camarasa, 1996, Antiviral research.

Synthesis and anti-HIV-1 activity of novel TSAO-T derivatives modified at the 2'- and 5'-positions of the sugar moiety.

E. De Clercq, J. Balzarini, M. Camarasa, 1995, Antiviral research.

TSAO DERIVATIVES: HIGHLY SPECIFIC INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS TYPE-1 (HIV-1) REPLICATION

J. Balzarini, E. Clercq, A. Karlsson, 1995 .

Metabolism and pharmacokinetics of the anti-HIV-1-specific inhibitor [1-[2′,5′-Bis-O-(tert-butyldimethylsilyl)-β-d-ribofuranosyl]-3-N-methyl-thymine]-3′-spiro-5″-(4″-amino-1″,2″-oxathiole-

L. Naesens, J. Balzarini, E. Clercq, 1993 .

TSAO derivatives: highly specific human immunodeficiency virus type 1 (HIV-1) reverse transcriptase inhibitors

J. Balzarini, A. Karlsson, M. Camarasa, 1993 .

Kinetics of inhibition of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase by the novel HIV-1-specific nucleoside analogue [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]-3'-spiro-5 "- (4"-amino-1",2"-oxathiole-2",2"-dioxide)thymine (TSAO-T).

E. De Clercq, P. Barr, J. Balzarini, 1992, The Journal of biological chemistry.

Differential mechanism of cytostatic effect of (E)-5-(2-bromovinyl)-2'-deoxyuridine, 9-(1,3-dihydroxy-2-propoxymethyl)guanine, and other antiherpetic drugs on tumor cells transfected by the thymidine kinase gene of herpes simplex virus type 1 or type 2.

E. De Clercq, J. Balzarini, C. Bohman, 1993, The Journal of biological chemistry.

Carbocyclic 5-iodo-2'-deoxyuridine (C-IDU) and carbocyclic (E)-5-(2-bromovinyl)-2'-deoxyuridine (C-BVDU) as unique examples of chiral molecules where the two enantiomeric forms are biologically active: interaction of the (+)- and (-)-enantiomers of C-IDU and C-BVDU with the thymidine kinase of herpe

E. De Clercq, J. Balzarini, H. Griengl, 1990, Molecular pharmacology.

Inhibitory effects of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and related compounds on herpes simplex virus (HSV)-infected cells and HSV thymidine kinase gene-transformed cells.

E. De Clercq, J. Balzarini, 1989, Methods and findings in experimental and clinical pharmacology.

Antiherpesvirus Activities of Two Novel 4′-Thiothymidine Derivatives, KAY-2-41 and KAH-39-149, Are Dependent on Viral and Cellular Thymidine Kinases

J. J. van den Oord, J. Balzarini, G. Andrei, 2014, Antimicrobial Agents and Chemotherapy.

Anti-herpesvirus Activity of Two Novel 4 ’-Thiothymidine Derivatives KAY-2-41 and KAH-39-149 is 1 dependent on viral and cellular thymidine kinases 2 3 4

J. Balzarini, G. Andrei, J. Oord, 2014 .

SYNTHESIS AND ANTIVIRAL ACTIVITY OF THE CARBOCYCLIC ANALOGS OF (E)‐5‐(2‐HALOVINYL)‐2′‐DEOXYURIDINES AND (E)‐5‐(2‐HALOVINYL)‐2′‐DEOXYCYTIDINES

P. Herdewijn, J. Balzarini, E. Clercq, 1985 .

Resistance to the nucleotide analogue cidofovir in HPV(+) cells: a multifactorial process involving UMP/CMP kinase 1

L. Naesens, J. Balzarini, G. Andrei, 2016, Oncotarget.

Stereocontrolled synthesis of 4'-C-cyano and 4'-C-cyano-4'-deoxy pyrimidine pyranonucleosides as potential chemotherapeutic agents.

J. Balzarini, A. Dimopoulou, S. Manta, 2012, Carbohydrate research.

6-Azathymidine-4′-thionucleosides: synthesis and antiviral evaluation

M. Jasamai, J. Balzarini, C. Simons, 2008 .

Design and synthesis of lipophilic phosphoramidate d4T-MP prodrugs expressing high potency against HIV in cell culture: structural determinants for in vitro activity and QSAR.

I. Gilbert, E. De Clercq, J. Balzarini, 1999, Journal of medicinal chemistry.

The presence of substituents on the aryl moiety of the aryl phosphoramidate derivative of d4T enhances anti-HIV efficacy in cell culture: A structure-activity relationship.

E. De Clercq, J. Balzarini, C. Mcguigan, 1999, Journal of medicinal chemistry.

Synthesis and Antiviral Evaluation of 4'-alkoxy Analogues of 9-(β-D-xylofuranosyl)adenine

M. Baba, J. Balzarini, K. Haraguchi, 2009, Antiviral chemistry & chemotherapy.

Estimation of the lipophilicity of anti-HIV nucleoside analogues by determination of the partition coefficient and retention time on a Lichrospher 60 RP-8 HPLC column.

E. De Clercq, J. Balzarini, E De Clercq, 1989, Biochemical and biophysical research communications.

Alpha, beta- and beta, gamma-methylene 5'-phosphonate derivatives of 3'-azido-2',3'-dideoxythymidine-5'-triphosphate. Correlation between affinity for reverse transcriptase, susceptibility to hydrolysis by phosphodiesterases and anti-retrovirus activity.

E. De Clercq, R. Pauwels, P. Herdewijn, 1988, Biochemical pharmacology.

Stereospecific Synthesis and Biological Evaluations of β‐L‐Pentofuranonucleoside Derivatives of 5‐Fluorouracil and 5‐Fluorocytosine.

J. Balzarini, E. Clercq, J. Sommadossi, 2001 .

Stereospecific Synthesis and NMR Conformational Studies of .gamma.-Butyrolactones of Nucleosides as Chiral Synthons for the Preparation of 2'-C- and 3'-C-Branched-Chain Nucleosides

J. Balzarini, M. Camarasa, S. Velázquez, 1994 .

Thiosugars. XII. Synthesis of New 3′‐O‐Substituted 2′,5′‐Anhydro‐2′‐thio‐α‐d‐pentofuranosyl Nucleoside Analogues

E. De Clercq, J. Balzarini, J. Wirsching, 2004, Nucleosides, nucleotides & nucleic acids.

Hydantoin derivatives of L- and D-amino acids: synthesis and evaluation of their antiviral and antitumoral activity.

E. De Clercq, K. Pavelić, M. Kralj, 2006, Molecules.

Dinucleoside Monophosphates Containing AZT and 1-Methyladenosine or 7-Methylguanosine

J. Balzarini, E. Clercq, S. Mikhailov, 2003, Nucleosides, Nucleotides & Nucleic Acids.

The Lantibiotic Peptide Labyrinthopeptin A1 Demonstrates Broad Anti-HIV and Anti-HSV Activity with Potential for Microbicidal Applications

J. Vanderleyden, J. Balzarini, D. Schols, 2013, PloS one.

Acyclic nucleoside thiophosphonates as potent inhibitors of HIV and HBV replication

F. Zoulim, J. Neyts, J. Balzarini, 2011, European Journal of Medicinal Chemistry.

N-3 Substituted TSAO Derivatives as a Probe to Explore the Dimeric Interface of HIV-1 Reverse Transcriptase

E. De Clercq, J. Balzarini, M. Camarasa, 2003, Nucleosides, Nucleotides & Nucleic Acids.

Identification of a putative binding site for [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)thymine (TSAO) derivatives at the p51-p66 interface of HIV-1 reverse transcriptase.

F. Gago, J. Balzarini, M. Camarasa, 2001, Journal of medicinal chemistry.

Synthesis, Antiviral and Cytostatic Activities of Carbocyclic Nucleosides Incorporating a Modified Cyclopentane Ring. Part 2. Adenosine and Uridine Analogues.

X. García‐Mera, J. Neyts, J. Balzarini, 1998 .

Role of thymidine kinase and thymidylate synthetase in the cytostatic, antimetabolic, and antitumor effects of the carbocyclic analogue of 5-nitro-2'-deoxyuridine. A comparison with 5-nitro-2'-deoxyuridine.

E. De Clercq, P. Herdewijn, J. Balzarini, 1985, Molecular pharmacology.

Novel carbocyclic nucleosides containing a cyclobutyl ring. Guanosine and adenosine analogues.

E. De Clercq, J. Balzarini, R. Snoeck, 1998, Nucleosides and Nucleotides.

Synthesis and Antiviral Activities of Some Novel Carbocyclic Nucleosides

J. Balzarini, E. Clercq, G. Andrei, 1996 .

(±)-7-deazaaristeromycin lacking the hydroxymethyl substituent

S. Ikeda, J. Balzarini, S. Siddiqi, 1993 .

Activity and Mechanism of Action of HDVD, a Novel Pyrimidine Nucleoside Derivative with High Levels of Selectivity and Potency against Gammaherpesviruses

J. J. van den Oord, Y. Cheng, C. K. Chu, 2013, Journal of Virology.

Design, synthesis and biological evaluation of 2′-deoxy-2′,2′-difluoro-5-halouridine phosphoramidate ProTides

J. Balzarini, A. Karlsson, C. Mcguigan, 2011, Bioorganic & Medicinal Chemistry.

Evaluation of Novel Phosphoramidate ProTides of the 2′-Fluoro Derivatives of a Potent Anti-Varicella Zoster Virus Bicyclic Nucleoside Analogue

A. Brancale, J. Balzarini, Marco Derudas, 2010, Antiviral chemistry & chemotherapy.

Dipeptidyl-peptidase IV (DPP IV/CD26)-activated prodrugs: a successful strategy for improving water solubility and oral bioavailability.

J. Balzarini, M. Camarasa, S. Velázquez, 2015, Current medicinal chemistry.

Efficient conversion of tetrapeptide-based TSAO prodrugs to the parent drug by dipeptidyl-peptidase IV (DPPIV/CD26).

A. Lambeir, J. Balzarini, M. Camarasa, 2007, Antiviral Research.

Discovery of TSAO derivatives with an unusual HIV-1 activity/resistance profile.

E. De Clercq, F. Gago, K. Van Laethem, 2006, Antiviral research.

Rapid microwave-enhanced synthesis of C5-alkynyl pyranonucleosides as novel cytotoxic antitumor agents.

Jan Balzarini, Ioannis Papasotiriou, J. Balzarini, 2013, Bioorganic & medicinal chemistry letters.

Efficient synthesis of exomethylene- and keto-exomethylene-d-glucopyranosyl nucleoside analogs as potential cytotoxic agents.

J. Balzarini, S. Manta, D. Komiotis, 2011, Carbohydrate research.

4"-Benzoylureido-TSAO derivatives as potent and selective non-nucleoside HCMV inhibitors. Structure-activity relationship and mechanism of antiviral action.

L. Naesens, J. Balzarini, M. Camarasa, 2008, Journal of Medicinal Chemistry.

Synthesis of [1-[3′,5′-Bis-O-(tert-butyldimethylsilyl)-β-d-arabino- and β-d-ribofuranosyl]cytosine]-2′-spiro-5″-(4″-amino-1″,2″-oxathiole-2″,2″-dioxide). Analogues of the highly specific anti-HIV-1 agent TSAO-T

J. Balzarini, M. Camarasa, S. Velázquez, 1994 .

Synthesis and antiviral activity of 3'-C-cyano-3'-deoxynucleosides.

E. De Clercq, Á. Díaz‐Ortiz, J. Balzarini, 1989, Journal of Medicinal Chemistry.

Dipeptidyl Peptidase IV‐Activated Prodrugs of Anti‐Varicella Zoster Virus Bicyclic Nucleoside Analogues Containing Different Self‐Cleavage Spacer Systems

J. Balzarini, M. Camarasa, S. Velázquez, 2012, ChemMedChem.

Synthesis of 3' '-substituted TSAO derivatives with anti-HIV-1 and anti-HIV-2 activity through an efficient palladium-catalyzed cross-coupling approach.

E. De Clercq, F. Gago, J. Balzarini, 2002, Journal of medicinal chemistry.

Identification of a novel family of nucleosides that specifically inhibit HIV-1 reverse transcriptase.

E. De Clercq, J. Balzarini, M. Camarasa, 2001, Bioorganic & Medicinal Chemistry Letters.

Exploitation of the Low Fidelity of Human Immunodeficiency Virus Type 1 (HIV-1) Reverse Transcriptase and the Nucleotide Composition Bias in the HIV-1 Genome To Alter the Drug Resistance Development of HIV

Jan Balzarini, Anna Karlsson, E. De Clercq, 2001, Journal of Virology.

4″-H-TSAO-T, A NOVEL PROTOTYPE IN THE HIV-1 SPECIFIC TSAO FAMILY

E. De Clercq, J. Balzarini, M. Camarasa, 2001, Nucleosides, nucleotides & nucleic acids.

“SECOND GENERATION” OF TSAO COMPOUNDS DIRECTED AGAINST HIV-1 TSAO-RESISTANT STRAINS

E. De Clercq, J. Balzarini, M. Camarasa, 2001, Nucleosides, nucleotides & nucleic acids.

Site-directed mutagenesis of human immunodeficiency virus type 1 reverse transcriptase at amino acid position 138.

A. Aertsen, E. De Clercq, A. Vandamme, 2001, Virology.

Presence of 2',5'-Bis-O-(tert-butyldimethylsilyl)-3'-spiro-5"-(4"-amino-1",2"-oxath iole-2",2"-dioxide) (TSAO)-resistant virus strains in TSAO-inexperienced HIV patients.

R. Esnouf, E. De Clercq, B. Clotet, 2000, AIDS research and human retroviruses.

TSAO-T Analogues Bearing Amino Acids at Position N-3 of Thymine: Synthesis and Anti-Human Immunodeficiency Virus Activity

E. De Clercq, J. Balzarini, C. Chamorro, 2000, Antiviral chemistry & chemotherapy.

Synthesis of Novel 5″-Substituted Tsao-T Analogues with Anti-Hiv-1 Activity

E. De Clercq, J. Balzarini, M. Camarasa, 2000 .

A novel mutation (F227L) arises in the reverse transcriptase of human immunodeficiency virus type 1 on dose-escalating treatment of HIV type 1-infected cell cultures with the nonnucleoside reverse transcriptase inhibitor thiocarboxanilide UC-781.

R. Esnouf, E. De Clercq, J. Balzarini, 1998, AIDS research and human retroviruses.

Characteristics of the Pro225His mutation in human immunodeficiency virus type 1 (HIV-1) reverse transcriptase that appears under selective pressure of dose-escalating quinoxaline treatment of HIV-1

R. Esnouf, E. De Clercq, A. Vandamme, 1997, Journal of virology.

Definitive Solution Structures for the 6-Formylated Versions of 1-(βD-Ribofuranosyl)-, 1-(2′-Deoxy-β-D-Ribofuranosyl)-, and 1-β-D-Arabinofuranosyluracil, and of Thymidine

R. Lin, J. Balzarini, E. Clercq, 1996 .

Novel Tsao Derivatives. Synthesis and Anti-HIV-1 Activity of Allofuranosyl-TSAO-T Analogues ‡

J. Balzarini, E. Clercq, M. Camarasa, 1996 .

Novel non-nucleoside human cytomegalovirus inhibitors based upon TSAO nucleoside derivatives: structure-activity relationships and mechanism of action

J. Balzarini, S. Velázquez, G. Andrei, 2008 .

Synthesis and antiviral activities of hexadecyloxypropyl prodrugs of acyclic nucleoside phosphonates containing guanine or hypoxanthine and a (S)-HPMP or PEE acyclic moiety

J. Balzarini, G. Andrei, M. Dračínský, 2012, European Journal of Medicinal Chemistry.

New prodrugs of Adefovir and Cidofovir

J. Balzarini, G. Andrei, M. Dračínský, 2011, Bioorganic & Medicinal Chemistry.

Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine: synthesis and antiviral activity.

E. De Clercq, L. Naesens, R. Pohl, 2007, Journal of medicinal chemistry.

Potential multifunctional inhibitors of HIV-1 reverse transcriptase. Novel [AZT]-[TSAO-T] and [d4T]-[TSAO-T] heterodimers modified in the linker and in the dideoxynucleoside region

J. Balzarini, E. Clercq, M. Camarasa, 1999 .

Potential multifunctional inhibitors of HIV-1 reverse transcriptase. Novel [AZT]-[TSAO-T] and [d4T]-[TSAO-T] heterodimers modified in the linker and in the dideoxynucleoside region.

E. De Clercq, J. Balzarini, M. Camarasa, 1999, Journal of Medicinal Chemistry.

New antivirals - mechanism of action and resistance development.

E. De Clercq, L. Naesens, J. Balzarini, 1998, Current opinion in microbiology.

3-deaza- and 7-deaza-5'-noraristeromycin and their antiviral properties.

E. De Clercq, S. Ikeda, J. Balzarini, 1995, Journal of medicinal chemistry.

7‐Deazaxanthine, a novel prototype inhibitor of thymidine phosphorylase

R. Esnouf, E. De Clercq, J. Neyts, 1998, FEBS letters.

Design, synthesis, antiviral and cytostatic evaluation of novel isoxazolidine nucleotide analogues with a carbamoyl linker

J. Balzarini, D. Piotrowska, Kamil Kokosza, 2013, Bioorganic & Medicinal Chemistry.

Synthesis, SAR, and preliminary mechanistic evaluation of novel antiproliferative N⁶,5'-bis-ureido- and 5'-carbamoyl-N⁶-ureidoadenosine derivatives.

J. Balzarini, J. Shelton, M. A. Peterson, 2012, Bioorganic & medicinal chemistry.

A conformationally locked analogue of the anti-HIV agent stavudine. An important correlation between pseudorotation and maximum amplitude.

Jan Balzarini, Stephen H Hughes, Clifford George, 2003, Journal of medicinal chemistry.

Synthesis and Biological Properties of (+) and (-)-(E)-5-(2-bronovinyl)-21 -deoxy-11 a-Carbauridine

J. Balzarini, E. Clercq, H. Griengl, 1989 .

Mechanism of the potentiating effect of ribavirin on the activity of 2',3'-dideoxyinosine against human immunodeficiency virus.

E. De Clercq, P. Herdewijn, J. Balzarini, 1991, The Journal of biological chemistry.

Mechanisms Associated with HIV-1 Resistance to Acyclovir by the V75I Mutation in Reverse Transcriptase*

R. Schinazi, L. Margolis, J. Balzarini, 2009, The Journal of Biological Chemistry.

Synthesis and anti-HIV evaluation of 2',3'-dideoxyribo-5-chloropyrimidine analogues: reduced toxicity of 5-chlorinated 2',3'-dideoxynucleosides.

E. De Clercq, G. Janssen, J. Balzarini, 1990, Journal of medicinal chemistry.

2',3'-didehydro-2',3'-dideoxy-5-chlorocytidine is a selective anti-retrovirus agent.

E. De Clercq, P. Herdewijn, A. Aerschot, 1989, Biochemical and biophysical research communications.

5-Chloro-substituted derivatives of 2', 3'-didehydro-2',3'-dideoxyuridine, 3'-fluoro-2',3'-dideoxyuridine and 3'-azido-2',3'-dideoxyuridine as anti-HIV agents.

E. De Clercq, P. Herdewijn, J. Balzarini, 1989, Biochemical pharmacology.

Novel antiviral C5-substituted pyrimidine acyclic nucleoside phosphonates selected as human thymidylate kinase substrates.

S. Eriksson, J. Balzarini, P. Meyer, 2011, Journal of medicinal chemistry.

Efficacy and adverse effects of the antiviral compound plerixafor in feline immunodeficiency virus-infected cats.

D. Klein, J. Balzarini, H. Egberink, 2012, Journal of veterinary internal medicine.

Potent antitumor activity of the acyclic nucleoside phosphonate 9‐(2‐phosphonylmethoxyethyl)adenine in choriocarcinoma‐bearing rats

E. De Clercq, L. Naesens, B. Degrève, 1998, International journal of cancer.

Efficacy of the acyclic nucleoside phosphonates (S)-9-(3-fluoro-2-phosphonylmethoxypropyl)adenine (FPMPA) and 9-(2-phosphonylmethoxyethyl)adenine (PMEA) against feline immunodeficiency virus.

E. De Clercq, L. Naesens, J. Balzarini, 1998, Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association.

Red blood cells mediated delivery of 9-(2-phosphonylmethoxyethyl)adenine to primary macrophages: efficiency metabolism and activity against human immunodeficiency virus or herpes simplex virus.

S. Grimaldi, C. Perno, J. Balzarini, 1997, Antiviral research.

9-(2-Phosphonylmethoxyethyl) adenine increases the survival of influenza virus-infected mice by an enhancement of the immune system.

E. De Clercq, C. Perno, J. Balzarini, 1994, Antiviral research.

9-(2-Phosphonylmethoxyethyl)adenine (PMEA) effectively inhibits retrovirus replication in vitro and simian immunodeficiency virus infection in rhesus monkeys.

E. De Clercq, L. Naesens, H. Niphuis, 1991, AIDS.

Anti‐retrovirus activity of 9‐(2‐phosphonylmethoxyethyl)adenine (pmea) in vivo increases when it is less frequently administered

L. Naesens, J. Balzarini, E. Clercq, 1990, International journal of cancer.

Suppression of feline immunodeficiency virus infection in vivo by 9-(2-phosphonomethoxyethyl)adenine.

E. De Clercq, H. Niphuis, J. Balzarini, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Inhibitory effects of 9‐(2‐Phosphonylmethoxyethyl)adenine and 3′‐azido‐2′,3′‐dideoxythymidine on tumor development in mice inoculated intracerebrally with moloney murine sarcoma virus

E. De Clercq, L. Naesens, J. Balzarini, 1990, International journal of cancer.

Inhibitory Effects ofAcyclic Nucleoside Phosphonates on HumanHepatitis BVirus andDuckHepatitis BVirus Infections inTissue Culture

J. Balzarini, R. Heijtink, E. Declercq, 1994 .

Acyclic adenine nucleoside phosphonates in plasma determined by high-performance liquid chromatography with fluorescence detection.

E. De Clercq, L. Naesens, J. Balzarini, 1992, Clinical chemistry.

Potent and selective anti-HTLV-III/LAV activity of 2',3'-dideoxycytidinene, the 2',3'-unsaturated derivative of 2',3'-dideoxycytidine.

E. De Clercq, R. Pauwels, P. Herdewijn, 1986, Biochemical and biophysical research communications.

A Multi-targeted Drug Candidate with Dual Anti-HIV and Anti-HSV Activity

L. Margolis, J. Balzarini, D. Schols, 2013, PLoS pathogens.

Antiretrovirus Activity of a Novel Class of Acyclic Pyrimidine Nucleoside Phosphonates

E. De Clercq, C. Pannecouque, C. Perno, 2002, Antimicrobial Agents and Chemotherapy.

Potent differentiation-inducing properties of the antiretroviral agent 9-(2-phosphonylmethoxyethyl) adenine (PMEA) in the rat choriocarcinoma (RCHO) tumor cell model.

E. De Clercq, L. Naesens, J. Balzarini, 1998, Biochemical pharmacology.

In vitro and in vivo inhibitory activity of the differentiation-inducing agent 9-(2-phosphonylmethoxyethyl)adenine (PMEA) against rat choriocarcinoma.

E. De Clercq, L. Naesens, B. Degrève, 1998, Advances in experimental medicine and biology.

Lipophilic Derivatization of the Antiviral Drug 9-(2-Phosphonylmethoxyethyl)adenine and Its Incorporation into a Lactosylated Lipid Carrier to Improve Its Liver Uptake

T. J. Berkel, J. Balzarini, E. Biessen, 1997 .

Comparative Anti-Retrovirus and Anti-Hepadnavirus Activity of Three Different Classes of Nucleoside Phosphonate Derivatives

E. De Clercq, J. Balzarini, R. Heijtink, 1994 .

Anti-retroviral and pharmacological properties of 9-(2-phosphonylmethoxyethyl) adenine (PMEA).

J. Balzarini, 1994, Advances in experimental medicine and biology.

Selective inhibition of human cytomegalovirus DNA synthesis by (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine [(S)-HPMPC] and 9-(1,3-dihydroxy-2-propoxymethyl)guanine (DHPG).

E. De Clercq, J. Neyts, J. Balzarini, 1990, Virology.

Strategies in the Design of Oligonucleotides as Potential Antiviral Agents

H. Sawai, J. Balzarini, E. Clercq, 1984 .

Design, Synthesis, and SAR of Naphthyl‐Substituted Diarylpyrimidines as Non‐Nucleoside Inhibitors of HIV‐1 Reverse Transcriptase

C. Pannecouque, J. Balzarini, Fener Chen, 2009, ChemMedChem.

Novel N-3 Substituted TSAO-T Derivatives: Synthesis and Anti-HIV-Evaluation

J. Balzarini, M. Camarasa, N. Sluis-Cremer, 2008, Nucleosides, nucleotides & nucleic acids.

Potent DNA chain termination activity and selective inhibition of human immunodeficiency virus reverse transcriptase by 2',3'-dideoxyuridine-5'-triphosphate.

J. Balzarini, C. Perno, D. Farquhar, 1990, Molecular pharmacology.

Antiadenovirus Activities of Several Classes of Nucleoside and Nucleotide Analogues

E. De Clercq, L. Naesens, J. Balzarini, 2005, Antimicrobial Agents and Chemotherapy.

Unsaturated Dideoxy Fluoro‐ketopyranosyl Nucleosides as New Cytostatic Agents: A Convenient Synthesis of 2,6‐Dideoxy‐3‐fluoro‐4‐keto‐β‐D‐glucopyranosyl Analogues of Uracil, 5‐Fluorouracil, Thymine, N4‐Benzoyl Cytosine and N6‐Benzoyl Adenine.

J. Balzarini, S. Manta, D. Komiotis, 2010 .

An investigation into the anti-HIV activity of 2',3'-didehydro-2',3'-dideoxyuridine (d4U) and 2',3'-dideoxyuridine (ddU) phosphoramidate 'ProTide' derivatives.

J. Balzarini, C. Mcguigan, Y. Mehellou, 2009, Organic & biomolecular chemistry.

Design, synthesis, and anti-HIV activity of 2',3'-didehydro-2',3'-dideoxyuridine (d4U), 2',3'-dideoxyuridine (ddU) phosphoramidate 'ProTide' derivatives.

A. Brancale, J. Balzarini, C. Mcguigan, 2007, Bioorganic & medicinal chemistry letters.

Exploiting the Anti-HIV-1 Activity of Acyclovir: Suppression of Primary and Drug-Resistant HIV Isolates and Potentiation of the Activity by Ribavirin

R. Schinazi, J. Grivel, L. Margolis, 2012, Antimicrobial Agents and Chemotherapy.

Transplacental Antiretroviral Therapy with 9-(2‐Phosphonylmethoxyethyl)adenine Is Embryotoxic in Transgenic Mice

R. Jaenisch, A. Sharpe, J. Balzarini, 1991, Journal of Acquired Immune Deficiency Syndromes.

Differential inhibitory effects of several pyrimidine 2',3'-dideoxynucleoside 5'-triphosphates on the activities of reverse transcriptase and various cellular DNA polymerases.

E. De Clercq, P. Herdewijn, J. Balzarini, 1989, Molecular Pharmacology.

Recent advances in thymidine kinase 2 (TK2) inhibitors and new perspectives for potential applications.

F. Gago, J. Balzarini, A. Karlsson, 2012, Current pharmaceutical design.

Retained Sensitivity to Cytotoxic Pyrimidine Nucleoside Analogs in Thymidine Kinase 2 Deficient Human Fibroblasts

J. Balzarini, A. Karlsson, M. Bjerke, 2010, Nucleosides, nucleotides & nucleic acids.

Mitochondrial Expression of the Drosophila melanogaster Multisubstrate Deoxyribonucleoside Kinase

Xinyu Zheng, J. Balzarini, A. Karlsson, 2007, Molecular Pharmacology.

Synthesis, X-ray crystal structural study, antiviral and cytostatic evaluations of the novel unsaturated acyclic and epoxide nucleoside analogues.

E. De Clercq, K. Pavelić, M. Kralj, 2006, Bioorganic & medicinal chemistry.

Design, synthesis and enzymatic activity of highly selective human mitochondrial thymidine kinase inhibitors.

L. Porcu, J. Balzarini, A. Karlsson, 2001, Bioorganic & Medicinal Chemistry Letters.

Cytotoxicity of 3'-azido-3'-deoxythymidine correlates with 3'-azidothymidine-5'-monophosphate (AZTMP) levels, whereas anti-human immunodeficiency virus (HIV) activity correlates with 3'-azidothymidine-5'-triphosphate (AZTTP) levels in cultured CEM T-lymphoblastoid cells.

S. Eriksson, J. Balzarini, B. Wahrén, 1995, Biochemical pharmacology.

Structure-Activity Relationship Studies on a Novel Family of Specific HIV-1 Reverse Transcriptase Inhibitors

E. De Clercq, J. Balzarini, M. Camarasa, 2003, Antiviral chemistry & chemotherapy.

Treatment of human immunodeficiency virus type 1 (HIV-1)-infected cells with combinations of HIV-1-specific inhibitors results in a different resistance pattern than does treatment with single-drug therapy

E. De Clercq, J. Balzarini, E. Clercq, 1993, Journal of virology.

Analogues of TSAO-T as the First Sugar Derivatives That Specifically Inhibit HIV-1 Reverse Transcriptase

F. Gago, J. Perez-Perez, J. Balzarini, 1998 .

Antiviral Activity of Bicyclic Pyrimidine Nucleosides

E. De Clercq, J. Balzarini, D. Loakes, 1995 .

Abasic analogues of TSAO-T as the first sugar derivatives that specifically inhibit HIV-1 reverse transcriptase.

E. De Clercq, F. Gago, J. Balzarini, 1998, Journal of medicinal chemistry.

Novel 3′-Spiro Nucleoside Analogues of TSAO-T. Part II. a Comparative Study Based on NMR Conformational Analysis in Solution and Theoretical Calculations

F. Gago, J. Balzarini, M. Jimeno, 1998, Antiviral chemistry & chemotherapy.

Novel Analogues of the Anti-HIV-1 Agent TSAO-T Modified at the 3′-Spiro Moiety

J. Balzarini, E. Clercq, M. Camarasa, 1997 .

The 2',3'-dideoxyriboside of 2,6-diaminopurine and its 2',3'-didehydro derivative inhibit the deamination of 2',3'-dideoxyadenosine, an inhibitor of human immunodeficiency virus (HIV) replication.

E. De Clercq, P. Herdewijn, J. Balzarini, 1987, Biochemical and biophysical research communications.

Discovery of a new family of inhibitors of human cytomegalovirus (HCMV) based upon lipophilic alkyl furano pyrimidine dideoxy nucleosides: action via a novel non-nucleosidic mechanism.

E. De Clercq, J. Balzarini, C. Mcguigan, 2004, Journal of Medicinal Chemistry.

Synthesis of [1-[2′,5′-bis-O-(t-Butyldimethylsilyl)-β- L-ribofuranosyl] thymine]-3′-spiro-5″-(4″-amino-1″,2″-oxathiole-2″,2″-dioxide) (L-TSAO-T)

J. Balzarini, E. Clercq, S. Ingate, 1995 .

Resistance of HIV-1 reverse transcriptase against [2',5'-bis-O-(tert-butyldimethylsilyl)-3'-spiro-5''-(4''-amino-1'',2''- oxathiole-2'',2''-dioxide)] (TSAO) derivatives is determined by the mutation Glu138-->Lys on the p51 subunit.

E. De Clercq, J. Balzarini, M. Camarasa, 1994, The Journal of biological chemistry.

Sensitivity of (138 Glu-->Lys) mutated human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) to HIV-1-specific RT inhibitors.

E. De Clercq, J. Balzarini, A. Karlsson, 1994, Biochemical and biophysical research communications.

Human immunodeficiency virus type 1 (HIV-1) strains selected for resistance against the HIV-1-specific [2',5'-bis-O-(tert-butyldimethylsilyl)-3'-spiro- 5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)]-beta-D-pentofurano syl (TSAO) nucleoside analogues retain sensitivity to HIV-1-specific nonnucleo

L. Vrang, A. Vandamme, B. Oberg, 1993, Proceedings of the National Academy of Sciences of the United States of America.

HIV-1-specific reverse transcriptase inhibitors show differential activity against HIV-1 mutant strains containing different amino acid substitutions in the reverse transcriptase.

E. De Clercq, L. Vrang, A. Vandamme, 1993, Virology.

Unexpected Results in the Reaction of 5′-Tosyl TSAO-m3T With Amines

F. Gago, A. Esteban-Gamboa, J. Balzarini, 1999 .

Oxathiin Carboxanilide Derivatives: A Class of Non-Nucleoside HIV-1-Specific Reverse Transcriptase Inhibitors (NNRTIs) that are Active against Mutant HIV-1 Strains Resistant to other NNRTIs

W. A. Harrison, E. De Clercq, J. Balzarini, 1995 .

Differential activities of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine derivatives against different human immunodeficiency virus type 1 mutant strains

E. De Clercq, M. Baba, J. Balzarini, 1995, Antimicrobial agents and chemotherapy.

Synthesis and anti-HIV properties of new water-soluble bis-functionalized[60]fullerene derivatives.

Jan Balzarini, Susanna Bosi, Maurizio Prato, 2003, Bioorganic & medicinal chemistry letters.

The Phenylmethylthiazolylthiourea Nonnucleoside Reverse Transcriptase (RT) Inhibitor MSK-076 Selects for a Resistance Mutation in the Active Site of Human Immunodeficiency Virus Type 2 RT

D. Stammers, E. De Clercq, L. Bird, 2004, Journal of Virology.

Susceptibility of feline immunodeficiency virus/human immunodeficiency virus type 1 reverse transcriptase chimeras to non-nucleoside RT inhibitors.

R. Esnouf, E. De Clercq, J. Balzarini, 2004, Molecular pharmacology.

Chimeric human immunodeficiency virus type 1 and feline immunodeficiency virus reverse transcriptases: role of the subunits in resistance/sensitivity to non-nucleoside reverse transcriptase inhibitors.

E. De Clercq, G. Klarmann, B. Preston, 2002, Molecular pharmacology.

Mutations at amino acid positions 63, 189, and 396 of human immunodeficiency virus type 1 reverse transcriptase (RT) partially restore the DNA polymerase activity of a Trp229Tyr mutant RT.

R. Esnouf, E. De Clercq, J. Balzarini, 2001, Virology.

Mutational Analysis of Tyr-318 within the Non-nucleoside Reverse Transcriptase Inhibitor Binding Pocket of Human Immunodeficiency Virus Type I Reverse Transcriptase*

R. Esnouf, E. De Clercq, J. Balzarini, 1998, The Journal of Biological Chemistry.

Preclinical studies on thiocarboxanilide UC‐781 as a virucidal agent

L. van Damme, E. De Clercq, L. Naesens, 1998, AIDS.

A proline-to-histidine substitution at position 225 of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) sensitizes HIV-1 RT to BHAP U-90152.

R. Esnouf, E. De Clercq, A. Vandamme, 1998, The Journal of general virology.

Design and synthesis of bio-isosteres of thymidine triphosphate.

I. Gilbert, J. Balzarini, A. Goldring, 1998, Bioorganic & medicinal chemistry letters.

Concomitant combination therapy for HIV infection preferable over sequential therapy with 3TC and non-nucleoside reverse transcriptase inhibitors.

E. De Clercq, J. Balzarini, A. Karlsson, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Treatment ofHumanImmunodeficiency VirusType1 (HIV-1)-Infected Cells withCombinations ofHIV-1-Specific Inhibitors Results ina Different Resistance Pattern Than DoesTreatment withSingle-Drug Therapy

J. Balzarini, E. Clercq, A. Karlsson, 1993 .

Pan-Pathway Based Interaction Profiling of FDA-Approved Nucleoside and Nucleobase Analogs with Enzymes of the Human Nucleotide Metabolism

P. Nordlund, S. Gräslund, S. Eriksson, 2012, PloS one.

Antiviral activity of sugar-modified derivatives of (E)-5-(2-bromovinyl)-2'-deoxyuridine

R. Busson, J. Balzarini, E. Clercq, 1982 .

9-Beta-D-arabinofuranosyladenine 5'-monophosphate (araAMP) is converted directly to its antivirally active 5'-triphosphate form by 5-phosphoribosyl-1-pyrophosphate (PRPP) synthetase.

E. De Clercq, J. Balzarini, 1990, Biochemical and biophysical research communications.

Combination of azidothymidine (AZT) and (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) inhibits the replication of herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) and varicella zoster virus (VZV) strains that are deficient in the expression of the viral thymidine kinase (TK)

J. Balzarini, E. Clercq, G. Andrei, 1995 .

Differential Intracellular Compartmentalization of Herpetic Thymidine Kinases (TKs) in TK Gene-Transfected Tumor Cells: Molecular Characterization of the Nuclear Localization Signal of Herpes Simplex Virus Type 1 TK

E. De Clercq, B. Degrève, J. Balzarini, 1998, Journal of Virology.

Herpes Simplex Virus Thymidine Kinase Gene-Transfected Tumor Cells; Sensitivity to Antiherpetic Drugs

J. Balzarini, 1996 .

Synthesis of 2′‐Deoxy‐5‐(isothiazol‐5‐yl)uridine and Its Interaction with the HSV‐1 Thymidine Kinase

P. Herdewijn, R. Busson, I. Luyten, 1996 .

Novel 3'-C/N-substituted 2',3'-beta-D-dideoxynucleosides as potential chemotherapeutic agents. 1. Thymidine derivatives: synthesis, structure, and broad spectrum antiviral properties.

E. De Clercq, J. Balzarini, J. Imbach, 1997, Journal of medicinal chemistry.

Thymidine Phosphorylase is Noncompetitively Inhibited by 5′-O-Trityl-Inosine (KIN59) and Related Compounds

E. De Clercq, J. Balzarini, S. Liekens, 2006, Nucleosides, nucleotides & nucleic acids.

The Nucleoside Derivative 5′-O-Trityl-inosine (KIN59) Suppresses Thymidine Phosphorylase-triggered Angiogenesis via a Noncompetitive Mechanism of Action*

E. De Clercq, D. Ribatti, J. Balzarini, 2004, Journal of Biological Chemistry.

Inhibition of replication of HIV in primary monocyte/macrophages by different antiviral drugs and comparative efficacy in lymphocytes

J. Balzarini, S. Aquaro, C. Perno, 1997, Journal of leukocyte biology.

Synthesis and Antiviral Activity of 1,3-Disubstituted Uracils against HIV-1 and HCMV

E. De Clercq, C. Pannecouque, J. Balzarini, 2003, Antiviral chemistry & chemotherapy.

1,1,3-Trioxo-2H,4H-Thieno[3,4-e][1,2,4]Thiadiazine (TTD) Derivatives: a New Class of Nonnucleoside Human Immunodeficiency Virus Type 1 (HIV-1) Reverse Transcriptase Inhibitors with Anti-HIV-1 Activity

R. Esnouf, E. De Clercq, C. Pannecouque, 1998, Antimicrobial Agents and Chemotherapy.

Design and Synthesis of Phosphonoacetic Acid (PPA) Ester and Amide Bioisosters of Ribofuranosylnucleoside Diphosphates as Potential Ribonucleotide Reductase Inhibitors and Evaluation of Their Enzyme Inhibitory, Cytostatic and Antiviral Activity

E. De Clercq, M. Ferrone, S. Pricl, 2003, Antiviral chemistry & chemotherapy.

Design and synthesis of phosphonoacetic acid ( PPA ) ester and amide bioisosters of ribofuranosylnucleo-side diphosphates as potential ribonucleotide reductase inhibitors and evaluation of their enzyme inhibitory , cytostatic and antiviral activity

M. Ferrone, S. Pricl, J. Balzarini, 2003 .

Dual mechanisms of 9-beta-D-arabinofuranosylguanine resistance in CEM T-lymphoblast leukemia cells.

J. Balzarini, A. Karlsson, M. Johansson, 2001, Biochemical and biophysical research communications.

Fluorescent bicyclic furo pyrimidine deoxynucleoside analogs as potent and selective inhibitors of VZV and potential future drugs for the treatment of chickenpox and shingles

A. Brancale, J. Balzarini, E. Clercq, 2000 .

5'-O-phosphonomethyl-2',3'-dideoxynucleosides: synthesis and anti-HIV activity.

J. Hoogmartens, E. De Clercq, P. Herdewijn, 1990, Journal of medicinal chemistry.

Application of the phosphoramidate ProTide approach to the antiviral drug ribavirin

L. Naesens, A. Brancale, J. Neyts, 2008, Bioorganic & Medicinal Chemistry.

Potential prodrug derivatives of 2',3'-didehydro-2',3'-dideoxynucleosides. Preparations and antiviral activities.

E. De Clercq, J. Balzarini, W. Bentrude, 1992, Journal of medicinal chemistry.

Thienothiadiazine 2,2-Dioxide Acyclonucleosides: Synthesis and Antiviral Activity

E. De Clercq, J. Balzarini, R. Snoeck, 2000, Antiviral chemistry & chemotherapy.

Enhancing the aqueous solubility of d4T-based phosphoramidate prodrugs.

E. De Clercq, J. Balzarini, C. Mcguigan, 2000, Bioorganic & medicinal chemistry letters.

Simple mono-derivatisation of the aryl moiety of D4A and DDA-based phosphoramidate prodrugs significantly enhances their anti-HIV potency in cell culture.

E. De Clercq, J. Balzarini, C. Mcguigan, 1999, Bioorganic & medicinal chemistry letters.

Synthesis and Evaluation of 5-Halo 2′,3′-Didehydro-2′,3′-Dideoxynucleosides and their Blocked Phosphoramidates as Potential Anti-Human Immunodeficiency virus Agents: An Example of ‘Kinase Bypass’

E. De Clercq, J. Balzarini, S. Velázquez, 1997 .

The antiviral activity of 9-beta-D-arabinofuranosyladenine is enhanced by the 2',3'-dideoxyriboside, the 2',3'-didehydro-2',3'-dideoxyriboside and the 3'-azido-2',3'-dideoxyriboside of 2,6-diaminopurine.

E. De Clercq, J. Balzarini, 1989, Biochemical and Biophysical Research Communications - BBRC.

Antiviral activity of N 4-aminocytidine derivatives related toAZT I

J. Balzarini, E. Clercq, 1994 .

Selective inhibition of human immunodeficiency virus (HIV) by 3'-azido-2', 3'-dideoxyguanosine in vitro.

E. De Clercq, R. Pauwels, P. Herdewijn, 1987, Biochemical and biophysical research communications.

5-Halogeno-3'-fluoro-2',3'-dideoxyuridines as inhibitors of human immunodeficiency virus (HIV): potent and selective anti-HIV activity of 3'-fluoro-2',3'-dideoxy-5-chlorouridine.

E. De Clercq, R. Pauwels, P. Herdewijn, 1989, Molecular pharmacology.

Synthesis and Antiviral Activity of Some 5′-N-Phthaloyl-3′-Azido-2′,3′-Dideoxythymidine Analogues

E. De Clercq, J. Balzarini, B. Kamińska, 2003, Antiviral chemistry & chemotherapy.

Assessment of the in vitro broad-spectrum antiviral activity of some selected antitumor organotin complexes

J. Balzarini, E. Clercq, R. Taylor, 1989 .

Assessment of the in vitro broad‐spectrum antiviral activity of some selected antitumor metallocene and metallocenium complexes

J. Balzarini, E. Clercq, R. Taylor, 1989 .

Principles of Antiretroviral Therapy for AIDS and Related Diseases

S. Broder, J. Balzarini, 1988 .

Antiviral activity of the 3'-amino derivative of (E)-5-(2-bromovinyl)-2'-deoxyuridine.

E. De Clercq, J. Balzarini, J. Descamps, 1983, The Biochemical journal.

Synthesis of Novel 6-Azapyrimidine Acyclic Nucleoside Analogues and Antiviral Evaluation

M. Jasamai, J. Balzarini, C. Simons, 2010, Nucleosides, nucleotides & nucleic acids.

Characterization of pyrimidine nucleoside phosphorylase of Mycoplasma hyorhinis: implications for the clinical efficacy of nucleoside analogues.

F. Gago, J. Balzarini, S. Liekens, 2012, The Biochemical journal.

Incorporation of carbocyclic (E)-5-(2-iodovinyl)-2'-deoxyuridine (C-IVDU) into DNA of herpes simplex virus-infected cells.

E. De Clercq, P. Herdewijn, A. Verbruggen, 1985, Antiviral research.

Role of histidine-85 in the catalytic mechanism of thymidine phosphorylase as assessed by targeted molecular dynamics simulations and quantum mechanical calculations.

J. Mendieta, F. Gago, J. Balzarini, 2004, Biochemistry.

Discovery of type II (covalent) inactivation of S-adenosyl-L-homocysteine hydrolase involving its "hydrolytic activity": synthesis and evaluation of dihalohomovinyl nucleoside analogues derived from adenosine.

E. De Clercq, R. Borchardt, J. Balzarini, 1998, Journal of medicinal chemistry.

Antiretroviral activities of acyclic nucleoside phosphonates [9-(2-phosphonylmethoxyethyl)adenine, 9-(2-phosphonylmethoxyethyl)guanine, (R)-9-(2-phosphonylmethoxypropyl)adenine, and MDL 74,968] in cell cultures and murine sarcoma virus-infected newborn NMRI mice

E. De Clercq, C. Pannecouque, J. Balzarini, 1997, Antimicrobial agents and chemotherapy.

Synthesis of novel antimitotic agents based on 2-amino-3-aroyl-5-(hetero)arylethynyl thiophene derivatives.

Jan Balzarini, Andrea Brancale, Ernest Hamel, 2011, Bioorganic & Medicinal Chemistry Letters.

Synthesis of Thymidine Analogues with a Cyanoimido Substituent

P. Herdewijn, A. Aerschot, J. Balzarini, 1991 .

Kinetic analysis of novel multisubstrate analogue inhibitors of thymidine phosphorylase

R. Esnouf, E. De Clercq, B. Degrève, 2000, FEBS letters.

Establishment of mutant murine mammary carcinoma FM3A cell strains transformed with the herpes simplex virus type 2 thymidine kinase gene.

E. De Clercq, T. Seno, D. Ayusawa, 1986, Cell structure and function.

Establishment of mutant FM3A murine mammary carcinoma cell strains transformed with the herpes simplex virus type 1 thymidine kinase gene.

E. De Clercq, T. Seno, D. Ayusawa, 1985, Japanese journal of cancer research : Gann.

Thymidine phosphorylase inhibitors: recent developments and potential therapeutic applications.

J. Balzarini, S. Liekens, M. Camarasa, 2005, Mini reviews in medicinal chemistry.

Synthesis and Biological Activity of a Series of Methylene-Expanded Oxetanocin Nucleoside Analogues

E. De Clercq, J. Balzarini, M. Jung, 2002 .

Doubly homologated dihalovinyl and acetylene analogues of adenosine: synthesis, interaction with S-adenosyl-L-homocysteine hydrolase, and antiviral and cytostatic effects.

E. De Clercq, R. Borchardt, C. A. Valdez, 2000, Journal of medicinal chemistry.

E. De Clercq, P. Barr, J. Balzarini, 1983, Journal of medicinal chemistry.

Antitumor cell and antimetabolic effects of 5-ethyl-2′-deoxyuridine and 5′-substituted 5-ethyl-2′-deoxyuridine derivatives

J. Balzarini, E. Clercq, G. Kiefer, 2004, Investigational New Drugs.

Alpba-Oligodeoxynucleotides as Inhibitors of HIV Reverse Transcriptase

R. Pauwels, M. Baba, J. Balzarini, 1989 .

Arabinosyl-5-a/acytosine: Mechanisms of Native and Acquired Resistance1

Gurpreet, J. Mcmahon, J. Balzarini, 2006 .

Arabinosyl-5-azacytosine: mechanisms of native and acquired resistance.

M. Cohen, J. Mcmahon, J. Balzarini, 1986, Cancer research.

Synthesis and biological evaluation of some cyclic phosphoramidate nucleoside derivatives.

R. T. Walker, E. De Clercq, J. Balzarini, 1990, Journal of medicinal chemistry.

Murine mammary FM3A carcinoma cells transformed with the herpes simplex virus type 1 thymidine kinase gene are highly sensitive to the growth‐inhibitory properties of (E)‐5‐(2‐bromovinyl)‐2'‐deoxyuridine and related compounds

E. De Clercq, T. Seno, D. Ayusawa, 1985, FEBS letters.

Differential inhibition of various deoxyribonucleic acid polymerases by Evans blue and aurintricarboxylic acid.

E. De Clercq, J. Balzarini, K. Ono, 1988, European journal of biochemistry.

Selective inhibition of HIV replication by adriamycin in macrophages but not in lymphocytes.

A. Bergamini, J. Balzarini, C. Perno, 1992, AIDS research and human retroviruses.

Stereospecific Synthesis and NMR Conformational Studies of γ- Butyrolactones of Nucleosides as Chiral Synthons for the Preparation of 2′-C- and 3′-C-Branched-Chain Nucleosides.

J. Balzarini, M. Camarasa, S. Velázquez, 2010 .

Thiosugars. Part 12. Synthesis of New 3′-O-Substituted 2′,5′-Anhydro-2′-thio-α-D-pentofuranosyl Nucleoside Analogues.

J. Balzarini, E. Clercq, G. Adiwidjaja, 2005 .

The human immunodeficiency virus(HIV) inhibitor 9‐(2‐phosphonylmethoxyethyl)adenine (pmea) is a strong inducer of differentiation of several tumor cell lines

E. De Clercq, J. Balzarini, A. Verstuyf, 1995, International journal of cancer.

The synthesis of nucleoside 5'-O-(1,1-dithiotriphosphates).

J. Balzarini, A. Okruszek, M. Olesiak, 1994, Journal of medicinal chemistry.

The dual role of thymidine phosphorylase in cancer development and chemotherapy

F. Gago, J. Balzarini, A. Bronckaers, 2009, Medicinal research reviews.

The cytostatic activity of 5‐(1‐azidovinyl)‐2′‐deoxyuridine (AzVDU) against herpes simplex virus thymidine kinase gene‐transfected FM3A cells is due to inhibition of thymidylate synthase and enhanced by UV light (λ = 254 nm) exposure

E. De Clercq, J. Balzarini, G. Andrei, 1995, FEBS letters.

Synthesis, antimycobacterial, antiviral, antimicrobial activity and QSAR studies of N(2)-acyl isonicotinic acid hydrazide derivatives.

B. Narasimhan, P. Yogeeswari, D. Sriram, 2012, Medicinal chemistry (Shariqah (United Arab Emirates)).

Potent and selective activity of 3'-azido-2,6-diaminopurine-2',3'-dideoxyriboside, 3'-fluoro-2,6-diaminopurine-2',3'-dideoxyriboside, and 3'-fluoro-2',3'-dideoxyguanosine against human immunodeficiency virus.

E. De Clercq, R. Pauwels, P. Herdewijn, 1988, Molecular pharmacology.

Structural basis for non-competitive product inhibition in human thymidine phosphorylase: implications for drug design.

D. Stammers, J. Balzarini, A. Bronckaers, 2006, The Biochemical journal.

Synthesis and biological properties of 2'-deoxy-5-vinyluridine and 2'deoxy-5-vinylcytidine.

R. T. Walker, E. De Clercq, J. Balzarini, 1982, Nucleic acids research.

Synthesis of 1‐(2‐deoxy‐β‐D‐ribofuranosyl)‐2,4‐ difluoro‐5‐(2‐halo‐1‐hydroxyethyl)benzenes and related derivatives: “thymine replacement” analogs of deoxythymidine for evaluation as antiviral and anticancer agents

E. De Clercq, J. Balzarini, L. Wiebe, 2001 .

Incorporation of 5-substituted pyrimidine nucleoside analogues into DNA of a thymidylate synthetase-deficient murine FM3A carcinoma cell line.

E. De Clercq, T. Seno, D. Ayusawa, 1985, Methods and findings in experimental and clinical pharmacology.

Mechanism of inhibitory effect of dextran sulfate and heparin on replication of human immunodeficiency virus in vitro.

J Desmyter, E. De Clercq, R. Pauwels, 1988, Proceedings of the National Academy of Sciences of the United States of America.

The Pyrimidine Nucleoside Phosphorylase of Mycoplasma hyorhinis and How It May Affect Nucleoside-Based Therapy

F. Gago, J. Balzarini, S. Liekens, 2014, Nucleosides, nucleotides & nucleic acids.

Targeting platelet-derived endothelial cell growth factor/thymidine phosphorylase for cancer therapy.

J. Balzarini, A. Bronckaers, S. Liekens, 2007, Biochemical pharmacology.

Synthesis, Solution Conformation and Anti-HIV Activity of Novel 3-Substituted-2′,3′-Dideoxy-5-Hydroxymethyl-Uridines and Their 4,5-Substituted Analogues

E. De Clercq, J. Poznański, J. Balzarini, 2003, Antiviral chemistry & chemotherapy.

P. Barr, J. Balzarini, E. Clercq, 1983 .

Synthesis and biological properties of some cyclic phosphotriesters derived from 2'-deoxy-5-fluorouridine.

R. T. Walker, E. De Clercq, J. Balzarini, 1984, Journal of medicinal chemistry.

Synthesis of an apionucleoside family and discovery of a prodrug with anti-HIV activity.

Davy Sinnaeve, P. Herdewijn, S. van Calenbergh, 2014, The Journal of organic chemistry.

Synthesis and biological evaluation of phosphonopyrimidine and phosphonopurine ribonucleosides.

E. De Clercq, J. Balzarini, T. Maruyama, 1987, Chemical & pharmaceutical bulletin.

2′-Deoxyuridines with a 5-Heteroaromatic Substituent: Synthesis and Biological Evaluation

E. De Clercq, C. Pannecouque, P. Herdewijn, 1995 .

Anti-HIV Derivatives of 1-(2,3-Dideoxy-3-N-hydroxyamino-β-D-threo-pentofuranosyl)thymine

I. Komáromi, K. Čapek, J. Tronchet, 1994 .

Synthesis and Biological Evaluation of a Series of Substituted 2-Pyridine C-Nucleosides: I. Coupling reaction of organo-metallic pyridine compounds with 2,4:3,5-di-O-benzylidene-aldehydo-D-ribose.

J. Balzarini, E. Clercq, R. Dommisse, 1985 .

Application of the dipeptidyl peptidase IV (DPPIV/CD26) based prodrug approach to different amine-containing drugs.

I. De Meester, J. Balzarini, M. Camarasa, 2010, Journal of medicinal chemistry.

Analogues de nucleotides enantiomeres antiretroviraux

J. Balzarini, A. Holý, H. Dvořáková, 1993 .

ALGAL CAROTENOIDS. LVIII: ISOMERIZATION STUDIES ON PERIDININ

U. Ragnarsson, J. Balzarini, G. Francis, 1994 .

3-Benzamido, ureido and thioureidoimidazo[1,2-a]pyridine derivatives as potential antiviral agents.

E. De Clercq, C. Pannecouque, A. Kherbeche, 2001, Chemical & pharmaceutical bulletin.

Synthesis of imidazo[1,2-a]pyridines as antiviral agents.

E. De Clercq, J. Balzarini, M. Witvrouw, 1998, Journal of medicinal chemistry.

Isoxazolidine analogs of nucleosides

A. Ricca, J. Tronchet, J. Balzarini, 1992 .

Influence of 2-substituent on the activity of imidazo[1,2-a] pyridine derivatives against human cytomegalovirus.

E. De Clercq, J. Balzarini, R. Snoeck, 2002, Bioorganic & medicinal chemistry.

Conservation of antiviral activity and improved selectivity in PMEO-DAPym upon pyrimidine to triazine scaffold hopping.

F. Gago, J. Balzarini, M. Camarasa, 2015, Antiviral research.

SYNTHESIS AND BIOLOGICAL EVALUATION OF PYRIDIN-2-ONE NUCLEOSIDES

J. Maillard, J. Balzarini, C. Simons, 2001, Nucleosides, nucleotides & nucleic acids.

Investigation of DNA biosynthesis catalyzed by DNA polymerases: approach of synthesis of compounds with anti-HIV activity.

J. Balzarini, V. Lukashov, A. Krayevsky, 1991, Nucleic acids symposium series.

Synthesis of 5-Substituted 2′-Deoxyuridine-5′- Phosphonate Analogues and Evaluation of their Antiviral Activity

Davy Sinnaeve, J. Balzarini, J. Martins, 2012, Nucleosides, nucleotides & nucleic acids.

Diastereoselective synthesis of cyclosaligenyl-nucleosyl-phosphotriesters.

J. Balzarini, C. Meier, Edwuin H Rios Morales, 2011, Chemistry.

Novel isoxazolidine analogues of homonucleosides and homonucleotides

J. Balzarini, D. Schols, G. Andrei, 2016, Tetrahedron.

Synthesis of novel isoxazolidine analogues of homonucleosides

J. Balzarini, D. Piotrowska, Joanna Gotkowska, 2012 .

Towards new C6-rigid S-DABO HIV-1 reverse transcriptase inhibitors: synthesis, biological investigation and molecular modeling studies.

E. De Clercq, C. Pannecouque, J. Balzarini, 2013, Bioorganic & Medicinal Chemistry.

Synthesis and evaluation of a (99m)Tc-MAMA-propyl-thymidine complex as a potential probe for in vivo visualization of tumor cell proliferation with SPECT.

J. Nuyts, L. Mortelmans, G. Bormans, 2007, Nuclear medicine and biology.

The Effect of a Methyl or 2-fluoroethyl Substituent at the N-3 Position of Thymidine, 3′-fluoro-3′-deoxythymi-dine and 1-β-D-arabinosylthymine on Their Antiviral and Cytostatic Activity in Cell Culture

G. Bormans, T. D. de Groot, A. Verbruggen, 2006, Antiviral chemistry & chemotherapy.

N‐3 Substituted TSAO Derivatives as a Probe to Explore the Dimeric Interface of HIV‐1 Reverse Transcriptase

J. Balzarini, E. Clercq, M. Camarasa, 2004 .

Synthesis and anti-HIV activity evaluation of 1-[(alkenyl or alkynyl or alkyloxy)methyl]-5-alkyl-6-(1-naphthoyl)-2,4-pyrimidinediones as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.

E. De Clercq, C. Pannecouque, J. Balzarini, 2007, European journal of medicinal chemistry.

The chemistry of 2' ,3'-seconucleosides II. Reactions and biological properties of 2',3'-secopyrimidine ribonucleosides

R. T. Walker, J. Balzarini, E. Clercq, 1985 .

Synthesis and biological evaluation of 1,2-disubstituted carbonucleosides of 6-substituted purine and 8-azapurine.

E Uriarte, L. Santana, E. Uriarte, 1999, Nucleosides & nucleotides.

Novel Carbocyclic Nucleosides Containing a Cyclopentyl Ring. Adenosine and Uridine Analogues

E. De Clercq, J. Balzarini, G. Andrei, 1997, Archiv der Pharmazie.

Metabolism of the Carbocyclic Analogue of (E)-5-(2-Iodovinyl)-Z'- deoxyuridine in Herpes Simplex Virus-infected Cells

P. Herdewijn, J. Balzarini, R. Bernaerts, 1985 .

Metabolism of the carbocyclic analogue of (E)-5-(2-iodovinyl)-2'-deoxyuridine in herpes simplex virus-infected cells. Incorporation of C-IVDU into DNA.

E. De Clercq, P. Herdewijn, A. Verbruggen, 1985, The Journal of biological chemistry.

Phosphoramidate derivatives of d4T with improved anti-HIV efficacy retain full activity in thymidine kinase-deficient cells

J. Balzarini, E. Clercq, C. Mcguigan, 1996 .

Synthesis and Antiviral Activity of 1,2-Carbonucleosides

L. Santana, E. Uriarte, M. Teijeira, 1995 .

Influence of Fluorination of the Sugar Moiety on the Anti-HIV-1 Activity of 2′,3′-Dideoxynucleosides

R. Pauwels, P. Herdewijn, A. Aerschot, 1989 .

Review article: MYCOPLASMAS AND CANCER: FOCUS ON NUCLEOSIDE METABOLISM

J. Balzarini, S. Liekens, J. Voorde, 2014 .

Synthesis and Antiviral Activities of Some Novel Carbocyclic Nucleosides.

J. Balzarini, G. Andrei, R. Snoeck, 1996 .

Novel carbocyclic nucleosides containing a cyclobutyl ring: adenosine analogues.

E. De Clercq, J. Balzarini, C. López, 2001, Chemical & pharmaceutical bulletin.

MODIFIED CYCLOBUTANE CARBONUCLEOSIDES: SYNTHESIS AND EVALUATION OF THEIR ANTIVIRAL ACTIVITY

E. De Clercq, J. Balzarini, C. López, 2001, Nucleosides, nucleotides & nucleic acids.

A CYCLOBUTANE CARBONUCLEOSIDE WITH MARKED SELECTIVITY AGAINST TK+ AND TK− VARICELLA ZOSTER VIRUS

E. De Clercq, J. Balzarini, C. López, 2001, Nucleosides, nucleotides & nucleic acids.

Introduction of a Fluorine Atom at C3 of 3-Deazauridine Shifts Its Antimetabolic Activity from Inhibition of CTP Synthetase to Inhibition of Orotidylate Decarboxylase, an Early Event in the de Novo Pyrimidine Nucleotide Biosynthesis Pathway*

A. V. van Kuilenburg, F. Gago, W. Kulik, 2012, The Journal of Biological Chemistry.

J. Balzarini, E. Clercq, P. Hatfield, 1985 .

2-Arylamino-4-amino-5-aroylthiazoles. "One-pot" synthesis and biological evaluation of a new class of inhibitors of tubulin polymerization.

A. Brancale, G. Basso, G. Viola, 2009, Journal of medicinal chemistry.

5′-Nor carbocyclic nucleosides: unusual nonnucleoside inhibitors of HIV-1 reverse transcriptase

J. Balzarini, S. Kochetkov, V. Valuev-Elliston, 2013 .

Carbocyclic 5'-nor "reverse" fleximers. Design, synthesis, and preliminary biological activity.

Joshua M. Sadler, J. Balzarini, G. Andrei, 2011, MedChemComm.

2'-Fluorosugar analogues of the highly potent anti-varicella-zoster virus bicyclic nucleoside analogue (BCNA) Cf 1743.

J. Balzarini, Marco Derudas, C. Mcguigan, 2009, Bioorganic & medicinal chemistry letters.

J. Balzarini, M. Camarasa, N. Sluis-Cremer, 2000, Biochemistry.

Human immunodeficiency virus type 1-specific [2',5'-bis-O-(tert- butyldimethylsilyl)-beta-D-ribofuranosyl]-3'-spiro-5"-(4"-amino-1",2"- oxathiole-2",2"-dioxide)-purine analogues show a resistance spectrum that is different from that of the human immunodeficiency virus type 1-specific non-nucleoside

E. De Clercq, J. Balzarini, A. Karlsson, 1993, Molecular pharmacology.

Tripartate Prodrugs of Hydroxy-containing Compounds

J. Balzarini, M. Camarasa, S. Velázquez, 2011 .

Prodrugs of Antiviral Nucleosides Cleavable by Dipeptidyl-Peptidase-IV (CD26)

J. Balzarini, M. Camarasa, S. Velázquez, 2008 .

Design and discovery of a novel dipeptidyl-peptidase IV (CD26)-based prodrug approach.

I. De Meester, J. Balzarini, M. Camarasa, 2006, Journal of medicinal chemistry.

Hybrids of [TSAO-T]-[foscarnet]: The first conjugate of foscarnet with a non-nucleoside reverse transcriptase inhibitor through a labile covalent ester bond.

E. De Clercq, J. Mellors, J. Balzarini, 2004, Journal of medicinal chemistry.

Synthesis of (1-(3′,5′-Bis-O-(tert-butyldimethylsilyl)-β-D- arabino- and β-D-ribofuranosyl)cytosine)-2′-spiro-5′′-(4′′-amino- 1′′,2′′-oxathiole-2′′,2′′-dioxide). Analogues of the Highly Specific anti-HIV-1 Agent TSAO-T.

J. Balzarini, M. Camarasa, S. Velázquez, 1995 .

Synthesis and Antiviral Activity of 3′-C-Cyano-3′-deoxynucleosides.

Á. Díaz‐Ortiz, J. Balzarini, E. Clercq, 1990 .

Synthesis of Novel 5′-Substituted TSAO-T Analogues with anti-HIV-1 Activity.

J. Balzarini, E. Clercq, M. Camarasa, 2000 .

Crystal structures of HIV-1 reverse transcriptase in complex with carboxanilide derivatives.

D I Stuart, R M Esnouf, D. Stuart, 1998, Biochemistry.

Models which explain the inhibition of reverse transcriptase by HIV-1-specific (thio)carboxanilide derivatives.

D I Stuart, R M Esnouf, D. Stuart, 1997, Biochemical and biophysical research communications.

Highly favorable antiviral activity and resistance profile of the novel thiocarboxanilide pentenyloxy ether derivatives UC-781 and UC-82 as inhibitors of human immunodeficiency virus type 1 replication.

E. De Clercq, C. Perno, J. Balzarini, 1996, Molecular pharmacology.

Novel TSAO Derivatives. Synthesis and Anti-HIV-1 Activity of Allofuranosyl-TSAO-T Analogues.

J. Balzarini, E. Clercq, M. Camarasa, 1996 .

Human immunodeficiency virus 1 (HIV-1)-specific reverse transcriptase (RT) inhibitors may suppress the replication of specific drug-resistant (E138K)RT HIV-1 mutants or select for highly resistant (Y181C-->C181I)RT HIV-1 mutants.

E. De Clercq, E. Emini, J. Balzarini, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Anti-HIV-1 Activity of Benzothiadiazine Dioxide

E. De Clercq, C. Pannecouque, C. Pérez, 2001, Antiviral chemistry & chemotherapy.

Synthesis and antiviral activity evaluation of acyclic 2′-azanucleosides bearing a phosphonomethoxy function in the side chain

J. Balzarini, E. Clercq, Mariola Koszytkowska-Stawińska, 2009, Bioorganic & Medicinal Chemistry.

Design, synthesis and bioevaluation of novel maleamic amino acid ester conjugates of 3,5-bisarylmethylene-4-piperidones as cytostatic agents.

E. De Clercq, A. Jha, J. Balzarini, 2009, Bioorganic & medicinal chemistry letters.

Intracellular metabolism of the N7-substituted acyclic nucleoside analog 2-amino-7-(1,3-dihydroxy-2-propoxymethyl)purine, a potent inhibitor of herpesvirus replication.

E. De Clercq, J. Neyts, J. Balzarini, 1998, Molecular pharmacology.

Structure—Antiviral Activity Relationship in the Series of Pyrimidine and Purine N-[2-(2-Phosphonomethoxy)ethyl] Nucleotide Analogues. Part 1. Derivatives Substituted at the Carbon Atoms of the Base.

J. Balzarini, E. Clercq, G. Andrei, 1999 .

Synthesis and Biological Evaluation of New 5,6-dichlorobenzimidazole Nucleoside Derivatives

E. De Clercq, J. Balzarini, J. Imbach, 1994 .

Synthesis and antiviral activity of carbocyclic oxetanocin analogues (C-OXT-A, C-OXT-G) and related compounds. II.

E. De Clercq, M. Hosoya, J. Balzarini, 1993, Chemical & pharmaceutical bulletin.

E. De Clercq, P. Herdewijn, J. Balzarini, 1989, Journal of medicinal chemistry.

Synthesis and Fluorescent Properties of 6-(4-Biphenylyl)-3,9-dihydro-9-oxo-5H-imidazo[1,2-A]purine Analogues of Acyclovir and Ganciclovir

E. De Clercq, J. Balzarini, T. Goslinski, 2003, Nucleosides, nucleotides & nucleic acids.

Synthesis and biological activity of strongly fluorescent tricyclic analogues of acyclovir and ganciclovir.

E. De Clercq, J. Balzarini, T. Goslinski, 2002, Journal of medicinal chemistry.

Acyclic Nucleotide Analogues Derived from 8-Azapurines: Synthesis and Antiviral Activity.

J. Balzarini, E. Clercq, G. Andrei, 2010 .

Synthesis of Ester Prodrugs of 9-(S)-[3-Hydroxy-2-(phosphonomethoxy)propyl]-2,6-diaminopurine (HPMPDAP) as Anti-Poxvirus Agents

L. Naesens, J. Neyts, J. Balzarini, 2010 .

(R)-9-(2-phosphonylmethoxypropyl)-2,6-diaminopurine is a potent inhibitor of feline immunodeficiency virus infection

E. De Clercq, L. Naesens, J. Balzarini, 1995, Antimicrobial agents and chemotherapy.

The potential of acyclic nucleoside phosphonates as broad-spectrum antiviral agents.

E. De Clercq, L. Naesens, J. Balzarini, 1995, Postepy biochemii.

Synthesis of O[2]- and N[3]-(2-phosphonomethoxy)ethyl derivatives of 6-phenyl- and 6-pyridinyl-5-azacytosine

J. Balzarini, G. Andrei, M. Dračínský, 2011 .

IN VIVO ANTIRETROVIRAL EFFICACY OF ORAL BIS(POM)-PMEA, THE BIS(PIVALOYLOXYMETHYL)PRODRUG OF 9-(2-PHOSPHONYLMETHOXYETHYL)ADENINE (PMEA)

L. Naesens, J. Neyts, J. Balzarini, 1995 .

Particular characteristics of the anti-human cytomegalovirus activity of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC) in vitro.

E. De Clercq, J. Neyts, J. Balzarini, 1991, Antiviral research.

Dipyridamole Potentiates the Activity of Various Acyclic Nucleoside Phosphonates against Varicella-Zoster Virus, Herpes Simplex Virus and Human Cytomegalovirus

E. De Clercq, J. Balzarini, G. Andrei, 1994 .

Therapeutic strategies towards HIV-1 infection in macrophages.

J. Balzarini, D. Schols, S. Aquaro, 2006, Antiviral research.

Non-inhibition of Acetylcholinesterase by cyclosal Nucleotides

J. Balzarini, C. Ducho, C. Meier, 2003, Nucleosides, nucleotides & nucleic acids.

BENZYL-FUNCTIONALIZED cycloSal-d4T MONOPHOSPHATES

E. De Clercq, J. Balzarini, C. Ducho, 2001, Nucleosides, nucleotides & nucleic acids.

Therapeutic potential of 9-(2-phosphonylmethoxyethyl)adenine (PMEA) as an antiviral drug

L. Naesens, J. Balzarini, E. Clercq, 1994 .

Carbocyclic Oxetanocins Lacking the C-3′ Methylene.

J. Balzarini, G. Andrei, R. Snoeck, 2010 .

Thymidylate synthase is the principal target enzyme for the cytostatic activity of (E)-5-(2-bromovinyl)-2'-deoxyuridine against murine mammary carcinoma (FM3A) cells transformed with the herpes simplex virus type 1 or type 2 thymidine kinase gene.

E. De Clercq, T. Seno, D. Ayusawa, 1987, Molecular pharmacology.

Mycoplasma hyorhinis-encoded cytidine deaminase efficiently inactivates cytosine-based anticancer drugs

J. Balzarini, S. Liekens, P. Vervaeke, 2015, FEBS open bio.

Diastereoselective synthesis of aryloxy phosphoramidate prodrugs of 3'-deoxy-2',3'-didehydrothymidine monophosphate.

J. Balzarini, C. Meier, C. A. Román, 2010, Journal of medicinal chemistry.

Structure--activity relationships for and potentiation of the antimitogenic activity of 2-5A core derived from 2-5A, a mediator of interferon action.

E. De Clercq, J. Balzarini, P. Torrence, 1983, Journal of medicinal chemistry.

Novel Lipophilic Hydroxyurea Derivatives: Synthesis, Cytostatic and Antiviral Activity Evaluations

K. Pavelić, J. Balzarini, E. Clercq, 2008, Chemical biology & drug design.

Conversion of acyclic nucleoside phosphonates to their diphosphate derivatives by 5-phosphoribosyl-1-pyrophosphate (PRPP) synthetase.

E. De Clercq, J. Balzarini, 1991, Advances in experimental medicine and biology.

Studies on enzyme-cleavable dialkoxymethyl-cyclosaligenyl-2',3'-dideoxy-2',3'-didehydrothymidine monophosphates.

J. Balzarini, N. Gisch, C. Meier, 2008, Journal of medicinal chemistry.

Bis-cycloSal-d4T-monophosphates: drugs that deliver two molecules of bioactive nucleotides.

S. Jessel, J. Balzarini, N. Gisch, 2007, Journal of medicinal chemistry.

Stereospecific synthesis and antiviral activities of beta-L-2',3'-dideoxy-5-chloropyrimidine nucleoside derivatives.

E. De Clercq, J. Balzarini, J. Imbach, 1999, Nucleosides & nucleotides.

Synthesis and Anti-HIV Evaluation of 2′,3′-Dideoxyribo-5-chloropyrimidine Analogues: Reduced Toxicity of 5-Chlorinated 2′,3′-Dideoxynucleosides.

P. Herdewijn, G. Janssen, A. Aerschot, 1990 .

2'-Azido-2',3'-dideoxythymidine: synthesis and crystal structure of a 2'-substituted dideoxynucleoside.

E. De Clercq, P. Herdewijn, J. Balzarini, 1990, Antiviral Research.

Analogues Classes of Nucleoside and Nucleotide Antiadenovirus Activities of Several

E. De Clercq, L. Naesens, J. Balzarini, 2005 .

Clinical efficacy of the acyclic nucleoside phosphonate 9-(2-phosphonylmethoxypropyl)-2,6-diaminopurine (PMPDAP) in the treatment of feline immunodeficiency virus-infected cats

J. Balzarini, K. Hartmann, N. Wilhelm, 2012, Journal of feline medicine and surgery.

Bicyclams, Selective Antagonists of the Human Chemokine Receptor CXCR4, Potently Inhibit Feline Immunodeficiency Virus Replication

E. De Clercq, Marian C. Horzinek, J. Balzarini, 1999, Journal of Virology.

In vitro Activity of Acyclic Nucleoside Phosphonate Derivatives against Feline Immunodeficiency Virus in Crandell Feline Kidney Cells and Feline Peripheral Blood Lymphocytes

N. Pedersen, E. De Clercq, J. Balzarini, 1994 .

PMPA and PMEA prodrugs for the treatment of HIV infections and human papillomavirus (HPV) associated neoplasia and cancer.

J. Balzarini, C. Mcguigan, A. Tristram, 2014, European journal of medicinal chemistry.

Evidence for distinction of the differentiation-inducing activities and cytostatic properties of 9-(2-phosphonylmethoxyethyl)adenine and a variety of differentiation-inducing agents in human erythroleukemia K562 cells.

E. De Clercq, J. Balzarini, S. Hatse, 1996, Molecular pharmacology.

Marked inhibitory activity of masked aryloxy aminoacyl phosphoramidate derivatives of dideoxynucleoside analogues against visna virus infection.

E. De Clercq, J. Balzarini, S. Velázquez, 1998, Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association.

Pronounced in vitro and in vivo antiretroviral activity of 5-substituted 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy] pyrimidines.

E. De Clercq, K. Van Laethem, J. Balzarini, 2006, The Journal of antimicrobial chemotherapy.

Potentiating effect of ribavirin on the anti-retrovirus activity of 3'-azido-2,6-diaminopurine-2',3'-dideoxyriboside in vitro and in vivo.

E. De Clercq, P. Herdewijn, J. Balzarini, 1989, Antiviral research.

Treatment of Visna Virus Infection in Lambs with the Acyclic Nucleoside Phosphonate Analogue 9-(2-Phosphonylmethoxyethyl)Adenine (PMEA)

E. De Clercq, L. Naesens, G. Georgsson, 1998, Antiviral chemistry & chemotherapy.

Assay method for monitoring the inhibitory effects of antimetabolites on the activity of inosinate dehydrogenase in intact human CEM lymphocytes.

E. De Clercq, J. Balzarini, E. Clercq, 1992, The Biochemical journal.

Induction of Erythroid Differentiation of Human Leukemia K562 Cells by the Acyclic Nucleoside Phosphonate 9-(2-Phosphonylmethoxyethyl)adenine (PMEA)

J. Balzarini, E. Clercq, S. Hatse, 1995 .

Microvirin, a Novel α(1,2)-Mannose-specific Lectin Isolated from Microcystis aeruginosa, Has Anti-HIV-1 Activity Comparable with That of Cyanovirin-N but a Much Higher Safety Profile*

E. Dittmann, J. Balzarini, D. Schols, 2010, The Journal of Biological Chemistry.

The Acyclic 2,4-Diaminopyrimidine Nucleoside Phosphonate Acts as a Purine Mimetic in HIV-1 Reverse Transcriptase DNA Polymerization*

B. Herman, J. Balzarini, N. Sluis-Cremer, 2010, The Journal of Biological Chemistry.

Synthesis of 2′‐Aminomethyl Derivatives of N‐(2‐(Phosphonomethoxy) ethyl) Nucleotide Analogues as Potential Antiviral Agents.

J. Balzarini, E. Clercq, R. Snoeck, 1996 .

Activities of Masked 2′,3′-Dideoxynucleoside Monophosphate Derivatives against Human Immunodeficiency Virus in Resting Macrophages

E. De Clercq, J. Balzarini, C. Mcguigan, 2000, Antimicrobial Agents and Chemotherapy.

Synthesis and Anti-HIV-1 Activity of 1-[ω-(Phenoxy)Alkyl and -Alkenyl]Uracil Derivatives

J. Balzarini, S. Kochetkov, V. Valuev-Elliston, 2013, Pharmaceutical Chemistry Journal.

9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP): A novel agent with anti-human immunodeficiency virus activity in vitro and potent anti-moloney murine sarcoma virus activity in vivo

L. Naesens, J. Balzarini, E. Clercq, 1989, European Journal of Clinical Microbiology and Infectious Diseases.

Inactivity of the bicyclic pyrimidine nucleoside analogues against simian varicella virus (SVV) does not correlate with their substrate activity for SVV-encoded thymidine kinase.

E. De Clercq, J. Balzarini, C. Mcguigan, 2004, Biochemical and biophysical research communications.

Novel N‐3 Substituted Tsao‐T Derivatives: Synthesis and anti‐HIV‐Evaluation.

J. Balzarini, M. Camarasa, N. Sluis-Cremer, 2008 .

Synthesis and an Antiviral Activity Evaluation of Nucleoside 5′-O-(N-acyl) Phosphoramidates

W. Stec, C. Pannecouque, J. Balzarini, 2011, Antiviral chemistry & chemotherapy.

Macrophages and HIV infection: therapeutical approaches toward this strategic virus reservoir.

J. Balzarini, E. Garaci, S. Aquaro, 2002, Antiviral research.

Lipophilic bioisosteres of nucleoside triphosphates

I. Gilbert, J. Balzarini, N. Mahmood, 1996 .

Isosteres of nucleoside triphosphates

I. Gilbert, J. Balzarini, N. Mahmood, 1996 .

5′,5′‐di‐O‐nucleosyl‐O′‐benzylphosphotriesters as potential prodrugs of 3′‐azido‐2′,3′‐dideoxythymidine‐5′‐monophosphate

J. Balzarini, E. D. Clercq, C. Meier, 1995 .

SYNTHESIS AND BIOLOGICAL EVALUATION OF ISONUCLEOSIDES DERIVED FROM METHYL 3,5-ANHYDRO-2-O-(2-FLUOROBENZYL)-d-XYLOFURANOSIDES

E. De Clercq, J. Balzarini, J. Wirsching, 2002, Nucleosides, nucleotides & nucleic acids.

Divergent synthesis and biological evaluation of carbocyclic α-, iso- and 3′-epi-nucleosides and their lipophilic nucleotide prodrugs

J. Balzarini, T. Krämer, C. Meier, 2006 .

Synthesis and Biological Evaluation of Unsaturated Keto and Exomethylene D-Arabinopyranonucleoside Analogues: Novel 5-Fluorouracil Analogues that Target Thymidylate Synthase.

J. Balzarini, S. Liekens, S. Manta, 2011 .

Novel bicyclic furanopyrimidines with dual anti-VZV and -HCMV activity.

E. De Clercq, A. Brancale, J. Balzarini, 2003, Bioorganic & medicinal chemistry letters.

Anti-Varicella—Zoster Virus Bicyclic Nucleosides: Replacement of Furo by Pyrro Base Reduces Antiviral Potency

E. De Clercq, J. Balzarini, C. Mcguigan, 2000, Antiviral chemistry & chemotherapy.

Altered deoxyribonucleotide pools in T‐lymphoblastoid cells expressing the multisubstrate nucleoside kinase of Drosophila melanogaster

J. Balzarini, A. Karlsson, A. Bertoli, 2005, The FEBS journal.

Cytosolic and mitochondrial deoxyribonucleotidases: activity with substrate analogs, inhibitors and implications for therapy.

J. Balzarini, A. Karlsson, C. Mazzon, 2003, Biochemical pharmacology.

Role of deoxycytidine kinase in the inhibitory activity of 5-substituted 2'-deoxycytidines and cytosine arabinosides on tumor cell growth.

E. De Clercq, J. Balzarini, 1983, Molecular pharmacology.

Palladium-catalyzed synthesis of (E)-5-(2-acylvinyl)-2′-deoxyuridines and their antiviral and cytotoxic activities

C. Spears, J. Balzarini, E. Clercq, 1995 .

Novel Nucleoside Phosphoramidates as Inhibitors of HIV: Studies on the Stereochemical Requirements of the Phosphoramidate Amino Acid

E. De Clercq, J. Balzarini, C. Mcguigan, 1996 .

Phosphoramidates as Potent Prodrugs of anti-HIV Nucleotides: Studies in the Amino Region

E. De Clercq, J. Balzarini, C. Mcguigan, 1996 .

Glycosyl-oxycarbonylaminosulfonyl-2',3'-dideoxynucleoside derivatives as lipophilic nucleotide mimics. Synthesis and anti-HIV activity.

E. De Clercq, J. Balzarini, M. Camarasa, 1993, Bioorganic & medicinal chemistry.

SYNTHESIS AND FLUORESCENT PROPERTIES OF THE TRICYCLIC ANALOGUES OF ACYCLOVIR LINKED WITH NITROGEN HETBROCYCLIC UNITS

E. De Clercq, J. Balzarini, T. Goslinski, 2005, Nucleosides, nucleotides & nucleic acids.

5-Quinone derivatives of 2'-deoxyuridine 5'-phosphate: inhibition and inactivation of thymidylate synthase, antitumor cell, and antiviral studies.

E. De Clercq, J. Balzarini, C. Decedue, 1987, Journal of medicinal chemistry.

Synthesis and Anti-Varicella-Zoster Virus Activity of Some Novel Bicyclic Nucleoside Inhibitors: Effect of Enhanced Aqueous Solubility

E. De Clercq, A. Brancale, J. Balzarini, 2000, Antiviral chemistry & chemotherapy.

Mechanism of cytostatic action of novel 5-(thien-2-yl)- and 5-(furan-2-yl)-substituted pyrimidine nucleoside analogues against tumor cells transfected by the thymidine kinase gene of herpes simplex virus.

E. De Clercq, P. Herdewijn, J. Balzarini, 1994, The Journal of biological chemistry.

Novel Analogues of the anti HIV-1 Agent TSAO-T Modified at the 3′-Spiro Moiety.

J. Balzarini, E. Clercq, M. Camarasa, 1998 .

Preparation of Some Acetylated Deoxy-pento- and -hexofuranoses and their Deacetylation.

U. Ragnarsson, J. Balzarini, E. Clercq, 1994 .

Synthesis and Biological Evaluation of Acyclic Nucleotide Analogues of Bicyclic Pyrimidine Bases

J. Balzarini, G. Andrei, R. Snoeck, 2009 .

Design and synthesis of novel non-nucleoside anti-HCMV agents [Abstract]

J. Balzarini, J. Vernachio, C. Mcguigan, 2008 .

Aryl furano pyrimidines: the most potent and selective anti-VZV agents reported to date.

J. Balzarini, C. Mcguigan, 2006, Antiviral research.

THE JOURNEY TOWARDS ELUCIDATING THE ANTI-HCMV ACTIVITY OF ALKYLATED BICYCLIC FURANO PYRIMIDINES

E. De Clercq, O. Bidet, J. Balzarini, 2005, Nucleosides, nucleotides & nucleic acids.

SYNTHESIS AND BIOLOGICAL EVALUATION OF N- AND O-ALKYLATED BICYCLIC FURANOPYRIMIDINES AS NON-NUCLEOSIDIC INHIBITORS OF HUMAN CYTOMEGALOVIRUS

E. De Clercq, J. Balzarini, C. Mcguigan, 2005, Nucleosides, nucleotides & nucleic acids.

Bicyclic Nucleoside Inhibitors of Varicella-Zoster Virus Modified on the Sugar Moiety: 3′ and 5′ Derivatives

E. De Clercq, J. Balzarini, C. Mcguigan, 2004, Antiviral chemistry & chemotherapy.

The potential impact of drug transporters on nucleoside-analog-based antiviral chemotherapy.

J. Wijnholds, P. Wielinga, G. Reid, 2004, Antiviral Research.

Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs.

F. Baas, E. De Clercq, J. Wijnholds, 2000, Proceedings of the National Academy of Sciences of the United States of America.

The Amino Acid Asn136 in HIV-1 Reverse Transcriptase (RT) Maintains Efficient Association of Both RT Subunits and Enables the Rational Design of Novel RT Inhibitors

E. De Clercq, F. Ceccherini‐Silberstein, A. Chedad, 2005, Molecular Pharmacology.

E. De Clercq, R. Borchardt, J. Balzarini, 1992, Journal of medicinal chemistry.

High Sequence Conservation of Human Immunodeficiency Virus Type 1 Reverse Transcriptase under Drug Pressure despite the Continuous Appearance of Mutations

F. Ceccherini‐Silberstein, F. Gago, A. Antinori, 2005, Journal of Virology.

Intestinal absorption characteristics of the low solubility thiocarboxanilide UC-781.

E. De Clercq, L. Naesens, J. Balzarini, 2002, International journal of pharmaceutics.

Solid state properties of pure UC‐781 and solid dispersions with polyvinylpyrrolidone (PVP K30)

L. Naesens, J. Balzarini, P. Augustijns, 2001, The Journal of pharmacy and pharmacology.

Suppression of the breakthrough of human immunodeficiency virus type 1 (HIV-1) in cell culture by thiocarboxanilide derivatives when used individually or in combination with other HIV-1-specific inhibitors (i.e., TSAO derivatives).

E. De Clercq, J. Balzarini, A. Karlsson, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Activity of various thiocarboxanilide derivatives against wild-type and several mutant human immunodeficiency virus type 1 strains.

E. De Clercq, J. Balzarini, A. Karlsson, 1995, Antiviral research.

Crystal structures of the mitochondrial deoxyribonucleotidase in complex with two specific inhibitors.

P. Nordlund, J. Balzarini, P. Reichard, 2004, Molecular pharmacology.

Reduced Levels of Mitochondrial DNA Increases the Toxicity of 9-ß-D-Arabinofuranosylguanine (araG)

J. Balzarini, A. Karlsson, M. Bjerke, 2008, Nucleosides, nucleotides & nucleic acids.

Increased sensitivity of thymidine kinase-deficient (TK-) tumor cell lines to the cell growth inhibitory effects of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and related compounds.

C. Crumpacker, E. De Clercq, T. Seno, 1986, Anticancer research.

In Search of Antiviral Compounds Against the AIDS Virus

R. Pauwels, P. Herdewijn, M. Baba, 1987 .

Highly selective cytostatic activity of (E)-5-(2-bromovinyl)-2'-deoxyuridine derivatives for murine mammary carcinoma (FM3A) cells transformed with the herpes simplex virus type 1 thymidine kinase gene.

E. De Clercq, T. Seno, D. Ayusawa, 1985, Molecular pharmacology.

SYNTHESIS OF 1-(2-DEOXY-β-D- RIBOFURANOSYL)-2,4-DIFLUORO-5-SUBSTITUTED-BENZENE THYMIDINE MIMICS,* SOME RELATED α-ANOMERS, AND THEIR EVALUATION AS ANTIVIRAL AND ANTICANCER AGENTS

E. De Clercq, J. Balzarini, L. Wiebe, 2001, Nucleosides, nucleotides & nucleic acids.

3'-(N-hydroxyimino)-2',3-dideoxynucleosides and their derivatives: synthesis, broad spectrum antiviral properties and synthetical application for the preparation of other nucleoside analogues.

E. De Clercq, J. Balzarini, J. Imbach, 1999, Nucleosides & nucleotides.

Synthesis and Biological Evaluationof 6-Substituted Purinylcarbanucleosides with a Cyclopenta[b]thiophene Pseudosugar

X. García‐Mera, J. Balzarini, E. Clercq, 2009 .

Substrate specificity of feline and canine herpesvirus thymidine kinase.

J. Balzarini, A. Karlsson, M. Johansson, 2008, Antiviral research.

Microwave-assisted synthesis of C-8 aryl and heteroaryl inosines and determination of their inhibitory activities against Plasmodium falciparum purine nucleoside phosphorylase.

J. Balzarini, A. Gigante, M. Camarasa, 2014, European journal of medicinal chemistry.

Antiviral Activity of 3-(3,5-Dimethylbenzyl)Uracil Derivatives Against Hiv-1 and HCMV

E. De Clercq, C. Pannecouque, J. Balzarini, 2007, Nucleosides, nucleotides & nucleic acids.

Antiretrovirus specificity and intracellular metabolism of 2',3' -didehydro-2',3'-dideoxythymidine (stavudine) and its 5'-monophosphate triester prodrug So324.

E. De Clercq, J. Balzarini, H. Egberink, 1996, Molecular pharmacology.

Preclinical development of bicyclic nucleoside analogues as potent and selective inhibitors of varicella zoster virus.

L. Naesens, A. Jones, E. Verbeken, 2007, The Journal of antimicrobial chemotherapy.

Bicyclic anti-VZV nucleosides: thieno analogues bearing an alkylphenyl side chain have reduced antiviral activity.

E. De Clercq, J. Balzarini, C. Mcguigan, 2004, Bioorganic & medicinal chemistry letters.

Bicyclic Nucleoside Inhibitors of Varicella-Zoster Virus: Effect of Terminal Aryl Substitution in the Side-Chain

E. De Clercq, J. Balzarini, C. Mcguigan, 2002, Antiviral chemistry & chemotherapy.

Bicyclic anti-VZV nucleosides: Thieno analogues retain full antiviral activity.

P. Savy, E. De Clercq, A. Brancale, 2001, Bioorganic & medicinal chemistry letters.

Synthesis and antiviral activity of boranophosphonate isosteres of AZT and d4T monophosphates.

C. De Michelis, J. Neyts, J. Balzarini, 2010, European journal of medicinal chemistry.

5′-O-Phosphonomethyl-2′,3′-dideoxynucleosides: Synthesis and Anti-HIV Activity.

J. Hoogmartens, P. Herdewijn, R. Busson, 1991 .

Side-chain derivatives of biologically active nucleosides. 1. Side-chain analogs of 3'-azido-3'-deoxythymidine (AZT).

E. De Clercq, J. Balzarini, E. Zbiral, 1992, Journal of medicinal chemistry.

Cyclo-saligenyl-2′,3′-dideoxy-2′,3′-didehydroythymidinemonophosphate (cycloSal-d4TMP) — A New Pro-Nucleotide Approach

J. Balzarini, M. Lorey, E. D. Clercq, 1997 .

Potential Prodrug Derivatives of 2′,3′-Didehydro-2′,3′-dideoxynucleosides. Preparations and Antiviral Activities.

J. Balzarini, E. D. Clercq, W. Bentrude, 1992 .

Novel potential agents for human cytomegalovirus infection: synthesis and antiviral activity evaluation of benzothiadiazine dioxide acyclonucleosides.

E. De Clercq, J. Balzarini, R. Snoeck, 1999, Journal of medicinal chemistry.

Synthesis, properties, and biological activity of some nucleoside cyclic phosphoramidates

R. T. Walker, E. De Clercq, J. Balzarini, 1984 .

Metabolism and Anti-HIV Activity of Phosphoramidate Derivatives of D4T-MP with Variations in the Amino Acid Moiety

L. Naesens, J. Balzarini, C. Mcguigan, 1998 .

Mechanism of antiviral and cytotoxic action of (+/-)-6' beta-fluoroaristeromycin, a potent inhibitor of S-adenosylhomocysteine hydrolase.

E. De Clercq, J. Balzarini, M. Cools, 1991, Molecular pharmacology.

NOVEL ARYL SUBSTITUTED BICYCLIC FURO NUCLEOSIDES AS EXTREMELY POTENT AND SELECTIVE ANTI-VZV AGENTS

E. De Clercq, J. Balzarini, C. Mcguigan, 2001, Nucleosides, nucleotides & nucleic acids.

2',3'-O-Cyclic derivatives of ribonucleosides and their 5'-phosphonates: synthesis and anti-HIV activity

J. Balzarini, E. Clercq, M. Jasko, 1991 .

SRR-SB 3 , a Disulfide-Containing Macrolide That Inhibits a Late Stage of the Replicative Cycle of Human Immunodeficiency Virus

C. Pannecouque, A. Vandamme, J. Balzarini, 1997 .

Virtual Screening of Acyclovir Derivatives as Potential Antiviral Agents: Design, Synthesis, and Biological Evaluation of New Acyclic Nucleoside ProTides.

A. Brancale, L. Margolis, J. Balzarini, 2017, Journal of medicinal chemistry.

Antiviral and antitumor structure-activity relationship studies on tetracyclic eudistomines.

H. W. Scheeren, E. De Clercq, J. Balzarini, 1992, Journal of medicinal chemistry.

Anti-HIV I/II activity and molecular cloning of a novel mannose/sialic acid-binding lectin from rhizome of Polygonatum cyrtonema Hua.

E. De Clercq, J. Bao, Lei Dai, 2006, Acta biochimica et biophysica Sinica.

Antiviral activity of carbohydrate-binding agents and the role of DC-SIGN in dengue virus infection.

J. Neyts, J. Balzarini, D. Schols, 2009, Virology.

Antiretroviral activity of semisynthetic derivatives of glycopeptide antibiotics.

E. De Clercq, C. Pannecouque, M. Preobrazhenskaya, 2003, Journal of medicinal chemistry.

Nonnucleoside human cytomegalovirus inhibitors: synthesis and antiviral evaluation of (chlorophenylmethyl)benzothiadiazine dioxide derivatives.

E. De Clercq, C. Pérez, J. Balzarini, 2000, Journal of medicinal chemistry.

REDUCTION OF 1-SUBSTITUTED 2,4,6-TRIPHENYLPYRIDINIUM IONS IN APROTIC MEDIA

U. Ragnarsson, J. Balzarini, G. Francis, 1994 .

Design, synthesis, in vitro antiproliferative activity and apoptosis-inducing studies of 1-(3′,4′,5′-trimethoxyphenyl)-3-(2′-alkoxycarbonylindolyl)-2-propen-1-one derivatives obtained by a molecular hybridisation approach

B. Cacciari, J. Balzarini, D. Schols, 2018, Journal of enzyme inhibition and medicinal chemistry.

Carbohydrate-Binding Agents: A Potential Future Cornerstone for the Chemotherapy of Enveloped Viruses?

J. Balzarini, 2007, Antiviral chemistry & chemotherapy.

Inhibition of HIV entry by carbohydrate-binding proteins.

J. Balzarini, J Balzarini, 2006, Antiviral research.

Safety concerns for the potential use of cyanovirin-N as a microbicidal anti-HIV agent.

J. Balzarini, D. Schols, D. Huskens, 2008, The international journal of biochemistry & cell biology.

Phosphorylation of dGMP analogs by vaccinia virus TMP kinase and human GMP kinase.

H. Munier-Lehmann, Constance Auvynet, J. Balzarini, 2009, Biochemical and biophysical research communications.

Crucial role of the N-glycans on the viral E-envelope glycoprotein in DC-SIGN-mediated dengue virus infection.

J. Neyts, J. Balzarini, D. Schols, 2012, Antiviral research.

Measuring cooperative Rev protein-protein interactions on Rev responsive RNA by fluorescence resonance energy transfer

C. Pannecouque, E. Pardon, J. Steyaert, 2011, RNA biology.

Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5.

J. Wijnholds, P. Wielinga, G. Reid, 2003, Molecular pharmacology.

[18F]FDG PET monitoring of tumour response to chemotherapy: does [18F]FDG uptake correlate with the viable tumour cell fraction?

Patrick Dupont, Jan Balzarini, Guy Bormans, 2003, European Journal of Nuclear Medicine and Molecular Imaging.

Role of MRP4 and MRP5 in biology and chemotherapy

L. Naesens, J. Schuetz, L. Matherly, 2008, AAPS PharmSci.

Synthesis of 5′‐N‐(α‐Amino‐β‐mercaptoacyl)amino‐5′‐deoxynucleosides as potential antiviral compounds

E. De Clercq, M. García-López, J. Balzarini, 1991 .

4-(beta-Arylvinyl)-3-(beta-arylvinylketo)-1-ethyl-4-piperidinols and related compounds: a novel class of cytotoxic and anticancer agents.

E. De Clercq, J. Quail, J. Dimmock, 1998, Journal of medicinal chemistry.

Viruses as key regulators of angiogenesis

J. Balzarini, S. Liekens, P. Vervaeke, 2011, Reviews in medical virology.

Identification of an indol-based derivative as potent and selective varicella zoster virus (VZV) inhibitor

E. Novellino, A. Bertamino, I. Gomez-Monterrey, 2016, European Journal of Medicinal Chemistry.

Tryptophan dendrimers that inhibit HIV replication, prevent virus entry and bind to the HIV envelope glycoproteins gp120 and gp41.

Jan Balzarini, Ignacio Colomer, J. Balzarini, 2015, European journal of medicinal chemistry.

Pradimicin A, a Carbohydrate-Binding Nonpeptidic Lead Compound for Treatment of Infections with Viruses with Highly Glycosylated Envelopes, Such as Human Immunodeficiency Virus

Jan Balzarini, Toshikazu Oki, Dominique Schols, 2006, Journal of Virology.

Inhibition of human immunodeficiency virus type 1 transcription by N-aminoimidazole derivatives.

E. De Clercq, C. Pannecouque, P. Herdewijn, 2007, Virology.

Carbohydrate Binding Agents: Potential Therapeutics with Multiple Inhibitory Actions against Enveloped Viruses

J. Balzarini, K. François, K. François, 2011 .

Antiviral activity of carbohydrate-binding agents against Nidovirales in cell culture

F. van der Meer, J. Balzarini, C. D. de Haan, 2007, Antiviral Research.

Large-molecular-weight carbohydrate-binding agents as HIV entry inhibitors targeting glycoprotein gp120

J. Balzarini, 2006, Current opinion in HIV and AIDS.

Targeting the glycans of gp120: a novel approach aimed at the Achilles heel of HIV.

J. Balzarini, 2005, The Lancet. Infectious diseases.

Actinohivin, a Broadly Neutralizing Prokaryotic Lectin, Inhibits HIV-1 Infection by Specifically Targeting High-Mannose-Type Glycans on the gp120 Envelope

K. Van Laethem, J. Balzarini, D. Schols, 2010, Antimicrobial Agents and Chemotherapy.

Resistance of HIV-1 to the broadly HIV-1-neutralizing, anti-carbohydrate antibody 2G12.

K. Van Laethem, J. Balzarini, D. Schols, 2007, Virology.

Mutational Pathways, Resistance Profile, and Side Effects of Cyanovirin Relative to Human Immunodeficiency Virus Type 1 Strains with N-Glycan Deletions in Their gp120 Envelopes

F. Gago, K. Van Laethem, J. Balzarini, 2006, Journal of Virology.

Novel Conjugated Unsaturated Ketones with Submicromolar Potencies Towards some Leukemic and Colon Cancer Cells.

Stephen G. Dimmock, J. Dimmock, J. Balzarini, 2019, Medicinal chemistry (Shariqah (United Arab Emirates)).

3,5-Bis(3-alkylaminomethyl-4-hydroxybenzylidene)-4-piperidones: A Novel Class of Potent Tumor-Selective Cytotoxins.

Stephen G. Dimmock, E. De Clercq, J. Dimmock, 2016, Journal of medicinal chemistry.

Cytotoxic 1,3-diarylidene-2-tetralones and related compounds.

E. De Clercq, J. Quail, J. Dimmock, 2002, European journal of medicinal chemistry.

Isonicotinic acid hydrazide derivatives: synthesis, antimicrobial activity, and QSAR studies

B. Narasimhan, P. Yogeeswari, D. Sriram, 2012, Medicinal Chemistry Research.

Design, synthesis and cytotoxic properties of novel 1-[4-(2-alkylaminoethoxy)phenylcarbonyl]-3,5-bis(arylidene)-4-piperidones and related compounds.

E. De Clercq, J. Dimmock, Rajendra K. Sharma, 2007, European journal of medicinal chemistry.

Entry of hepatitis C virus and human immunodeficiency virus is selectively inhibited by carbohydrate-binding agents but not by polyanions.

J. Balzarini, D. Schols, D. Daelemans, 2007, Virology.

Carbohydrate-binding Agents Cause Deletions of Highly Conserved Glycosylation Sites in HIV GP120

M. Froeyen, K. Van Laethem, J. Balzarini, 2005, Journal of Biological Chemistry.

Several N-Glycans on the HIV Envelope Glycoprotein gp120 Preferentially Locate Near Disulphide Bridges and Are Required for Efficient Infectivity and Virus Transmission

J. Balzarini, Leen Mathys, 2015, PloS one.

The carbohydrate-binding plant lectins and the non-peptidic antibiotic pradimicin A target the glycans of the coronavirus envelope glycoproteins

B. Bosch, F. van der Meer, J. Balzarini, 2007, The Journal of antimicrobial chemotherapy.

Inhibition of infection and transmission of HIV-1 and lack of significant impact on the vaginal commensal lactobacilli by carbohydrate-binding agents.

M. Vaneechoutte, S. Lebeer, J. Vanderleyden, 2013, The Journal of antimicrobial chemotherapy.

A highly reliable, sensitive, flow cytometric/fluorometric assay for the evaluation of the anti-HIV activity of antiviral compounds in MT-4 cells.

E. De Clercq, R. Pauwels, J. Balzarini, 1988, Journal of immunological methods.

Different Evolution of Genotypic Resistance Profiles to Emtricitabine Versus Lamivudine in Tenofovir-Containing Regimens

F. Ceccherini‐Silberstein, P. Narciso, K. Van Laethem, 2010, Journal of acquired immune deficiency syndromes.

Evaluating Clinical Isolates for Their Phenotypic and Genotypic Resistance Against Anti-HIV Drugs.

J Desmyter, E. De Clercq, C. Pannecouque, 2000, Methods in molecular medicine.

Stability of UC-781, in Intestinal Mucosal Homogenates of the Rat, Rabbit, and Pig

L. Naesens, J. Balzarini, P. Augustijns, 1998, Pharmaceutical Research.

Surface Glycans: A Therapeutic Opportunity for Kinetoplastid Diseases.

J. Balzarini, D. González-Pacanowska, Víctor M. Castillo-Acosta, 2017, Trends in parasitology.

HIV‐1 envelope trimer has similar binding characteristics for carbohydrate‐binding agents as monomeric gp120

R. Sanders, J. Balzarini, Y. Igarashi, 2013, FEBS letters.

The Highly Conserved Glycan at Asparagine 260 of HIV-1 gp120 Is Indispensable for Viral Entry*

J. Balzarini, K. François, 2011, The Journal of Biological Chemistry.

Sugar-Binding Proteins Potently Inhibit Dendritic Cell Human Immunodeficiency Virus Type 1 (HIV-1) Infection and Dendritic-Cell-Directed HIV-1 Transfer

J. Balzarini, D. Schols, S. Turville, 2005, Journal of Virology.

Marked Depletion of Glycosylation Sites in HIV-1 gp120 under Selection Pressure by the Mannose-Specific Plant Lectins of Hippeastrum Hybrid and Galanthus nivalis

E. De Clercq, M. Froeyen, K. Van Laethem, 2005, Molecular Pharmacology.

Engineering Lactobacillus rhamnosus GG and GR-1 to express HIV-inhibiting griffithsin.

S. Lebeer, J. Vanderleyden, J. Balzarini, 2018, International journal of antimicrobial agents.

Structural features and anti-human immunodeficiency virus (HIV) activity of the isomers of 1-(2',6'-difluorophenyl)-l H,3H-thiazo lo(3,4-a)benzimidazole, a potent non-nucleoside HIV-1 reverse transcriptase inhibitor

J. Balzarini, A. Chimirri, P. Monforte, 1997 .

Phosphorylation of 3´-Azidothymidine in Maternal and Fetal Peripheral Blood Mononuclear Cells During Gestation and at Term

E. Manor, J. Balzarini, R. Agbaria, 2003, Journal of acquired immune deficiency syndromes.

The cytostatic activity of pyrimidine nucleosides is strongly modulated by Mycoplasma hyorhinis infection: Implications for cancer therapy.

J. Balzarini, A. Bronckaers, S. Liekens, 2008, Biochemical pharmacology.

Pradimicin S, a Highly Soluble Nonpeptidic Small-Size Carbohydrate-Binding Antibiotic, Is an Anti-HIV Drug Lead for both Microbicidal and Systemic Use

K. Van Laethem, J. Balzarini, D. Schols, 2010, Antimicrobial Agents and Chemotherapy.

Design, synthesis and bioevaluation of novel 6-(4-Hydroxypiperidino)naphthalen-2-ol-based potential Selective Estrogen Receptor Modulators for breast cancer.

A. Jha, C. K. Too, J. Balzarini, 2015, European journal of medicinal chemistry.

A novel tetrameric lectin from Lycoris aurea with four mannose binding sites per monomer.

J. Bao, J. Balzarini, E. V. Van Damme, 2007, Acta biochimica Polonica.

Characterization and Structural Analysis of Novel Mutations in Human Immunodeficiency Virus Type 1 Reverse Transcriptase Involved in the Regulation of Resistance to Nonnucleoside Inhibitors

Thomas Lengauer, Stefano Alcaro, Jan Balzarini, 2007, Journal of Virology.

Mutations in the non-nucleoside binding-pocket interfere with the multi-nucleoside resistance phenotype

R. Esnouf, E. De Clercq, C. Pannecouque, 2001, AIDS.

Thioredoxin-1 and protein disulfide isomerase catalyze the reduction of similar disulfides in HIV gp120.

H. Jörnvall, T. Bergman, J. Balzarini, 2012, The international journal of biochemistry & cell biology.

The Crystal Structure of I2O4 and its Relations to Other Iodine--Oxygen-Containing Compounds.

H. Fjellvåg, U. Ragnarsson, J. Balzarini, 1994 .

Substituted 2-(3',4',5'-trimethoxybenzoyl)-benzo[b]thiophene derivatives as potent tubulin polymerization inhibitors.

A. Brancale, O. Cruz-López, J. Balzarini, 2010, Bioorganic & Medicinal Chemistry.

Fullerenolates: metallated polyhydroxylated fullerenes with potent anti-amyloid activity.

P. Troshin, J. Balzarini, A. Kornev, 2011, Organic & biomolecular chemistry.

Amides of antibiotic streptonigrin and amino dicarboxylic acids or aminosugars. Synthesis and biological evaluation.

N. V. Kozlova, E. De Clercq, V. Tolstikov, 1992, The Journal of antibiotics.

Novel linked antiviral and antitumor agents related to netropsin - 2: Synthesis and biological evaluation

J. Lown,, R. Newman, J. Balzarini, 1991 .

Engineering of a Single Conserved Amino Acid Residue of Herpes Simplex Virus Type 1 Thymidine Kinase Allows a Predominant Shift from Pyrimidine to Purine Nucleoside Phosphorylation*

D. Stammers, J. Balzarini, A. Karlsson, 2006, Journal of Biological Chemistry.

Synthesis, antiplasmodial activity and mechanistic studies of pyrimidine-5-carbonitrile and quinoline hybrids.

K. Chibale, Peter J. Smith, J. Balzarini, 2015, European journal of medicinal chemistry.

Prognostic value of positron emission tomography (PET) with fluorine-18 fluorodeoxyglucose ([18F]FDG) after first-line chemotherapy in non-Hodgkin's lymphoma: is [18F]FDG-PET a valid alternative to conventional diagnostic methods?

P. Dupont, L. Mortelmans, G. Bormans, 2001, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Role of Human Hypoxanthine Guanine Phosphoribosyltransferase in Activation of the Antiviral Agent T-705 (Favipiravir)

L. Naesens, A. V. van Kuilenburg, L. Guddat, 2013, Molecular Pharmacology.

Investigation of fatty acid conjugates of 3,5-bisarylmethylene-4-piperidone derivatives as antitumor agents and human topoisomerase-IIα inhibitors.

H. Rupasinghe, K. S. Bhullar, A. Jha, 2015, Bioorganic & medicinal chemistry.

Synthesis of Imidazo[1,2-a]pyridine Derivatives as Antiviral Agents

E. De Clercq, J. Balzarini, G. Andrei, 2001, Arzneimittelforschung.

Can positron emission tomography with [18F]‐fluorodeoxyglucose after first‐line treatment distinguish Hodgkin's disease patients who need additional therapy from others in whom additional therapy would mean avoidable toxicity?

P. Dupont, L. Mortelmans, S. Stroobants, 2001, British journal of haematology.

Differential inhibition of retroviral reverse transcriptase by poly(2-fluoroadenylic acid), a template analogue.

E. De Clercq, J. Balzarini, K. Kohda, 1991, AIDS.

Synthesis of 3‐Nitrosoimidazo[1,2‐a]pyridine Derivatives as Potential Antiretroviral Agents

E. De Clercq, C. Pannecouque, A. Kherbeche, 2001, Archiv der Pharmazie.

Study of the Efficacy of a Pronucleotide of 2-Chloro-2′-Deoxyadenosine in Deoxycytidine Kinase-Deficient Lymphoma Cells

C. Galmarini, F. Bontemps, J. Balzarini, 2006, Nucleosides, nucleotides & nucleic acids.

Discovery of novel diarylpyrimidines as potent HIV NNRTIs via a structure-guided core-refining approach.

Peng Zhan, Jan Balzarini, Ye Tian, 2014, European journal of medicinal chemistry.

Composes inhibant le replication du virus de l'immunodeficience humaine

J. Balzarini, M. Högberg, Anders Vahlne, 2005 .

E,E-2-Benzylidene-6-(nitrobenzylidene)cyclohexanones: syntheses, cytotoxicity and an examination of some of their electronic, steric, and hydrophobic properties.

E. De Clercq, J. Dimmock, J. Balzarini, 2008, Bioorganic & medicinal chemistry.

Structure-activity relationship of brominated 3-alkyl-5-methylene-2(5H)-furanones and alkylmaleic anhydrides as inhibitors of Salmonella biofilm formation and quorum sensing regulated bioluminescence in Vibrio harveyi.

S. D. De Keersmaecker, A. De Weerdt, J. Vanderleyden, 2010, Bioorganic & medicinal chemistry.

Limited development and progression of resistance of HIV-1 to the nucleoside analogue reverse transcriptase inhibitor lamivudine in human primary macrophages.

F. Ceccherini‐Silberstein, J. Balzarini, S. Aquaro, 2005, The Journal of antimicrobial chemotherapy.

Sensitivity/resistance profile of a simian immunodeficiency virus containing the reverse transcriptase gene of human immunodeficiency virus type 1 (HIV-1) toward the HIV-1-specific non-nucleoside reverse transcriptase inhibitors.

E. De Clercq, K. Uberla, J. Balzarini, 1995, Biochemical and biophysical research communications.

Synthesis, characterization, antitumor, and cytotoxic activity of mononuclear Ru(II) complexes

J. Balzarini, E. Clercq, S. Karki, 2010 .

Evaluation of the Toxicity of 5-Aryl-2-Aminoimidazole-Based Biofilm Inhibitors against Eukaryotic Cell Lines, Bone Cells and the Nematode Caenorhabditis elegans

M. Fröhlich, H. Steenackers, L. Girandon, 2014, Molecules.

Design, synthesis and biological evaluation of phosphorodiamidate prodrugs of antiviral and anticancer nucleosides

A. Kolykhalov, L. Margolis, J. Balzarini, 2013, European Journal of Medicinal Chemistry.

Synthesis, structural characterization, and biological studies of new antimony(III) complexes with thiones. The influence of the solvent on the geometry of the complexes.

J. Balzarini, N. Hadjiliadis, I. Butler, 2007, Inorganic chemistry.

Exposure of Trypanosoma brucei to an N-acetylglucosamine-Binding Lectin Induces VSG Switching and Glycosylation Defects Resulting in Reduced Infectivity

J. Balzarini, E. V. Van Damme, D. González-Pacanowska, 2015, PLoS neglected tropical diseases.

Alpha-carboxy nucleoside phosphonates as universal nucleoside triphosphate mimics

L. Naesens, E. Arnold, W. Dehaen, 2015, Proceedings of the National Academy of Sciences.

Nucleoside Diphosphate Prodrugs: Nonsymmetric DiPPro-Nucleotides.

J. Balzarini, D. Schols, C. Meier, 2015, Journal of medicinal chemistry.

Bioreversible protection of nucleoside diphosphates.

J. Balzarini, C. Meier, H. Jessen, 2008, Angewandte Chemie.

A phenyl-thiadiazolylidene-amine derivative ejects zinc from retroviral nucleocapsid zinc fingers and inactivates HIV virions

C. Pannecouque, W. Dehaen, Y. Mély, 2012, Retrovirology.

Synergistic in vitro anti-HIV type 1 activity of tenofovir with carbohydrate-binding agents (CBAs).

E. Dittmann, M. Swanson, D. Markovitz, 2011, Antiviral research.

Lactate cannot substitute for alanine in d4T-based anti-HIV nucleotide prodrugs--despite efficient esterase-mediated hydrolysis.

E. De Clercq, J. Balzarini, C. Mcguigan, 1998, Bioorganic & medicinal chemistry letters.

Synthesis and Biological Evaluation of Phosphonate Derivatives of Some Acyclic Pyridine-C-Nucleosides

J. Balzarini, E. Clercq, R. Dommisse, 1998 .

A QSAR study investigating the effect of L-alanine ester variation on the anti-HIV activity of some phosphoramidate derivatives of d4T.

I. Gilbert, J. Balzarini, C. Mcguigan, 2000, Bioorganic & medicinal chemistry letters.

Cyclosaligenyl-2 9 , 3 9-didehydro-2 9 , 3 9-dideoxythymidine Monophosphate : Efficient Intracellular Delivery of d 4 TMP

J. Balzarini, E. Clercq, S. Aquaro, 2000 .

An in situ pig liver esterase assay as a useful predictive tool for the likely in vitro anti viral activity of phosphoramidate pro-drugs.

E. De Clercq, J. Balzarini, C. Mcguigan, 1999, Nucleosides & nucleotides.

Intracellular Metabolism of Cyclo Saligenyl 3 9-Azido-2 9 , 3 9-dideoxythymidine Monophosphate , a Prodrug of 3 9-Azido-2 9 , 3 9-dideoxythymidine ( Zidovudine )

L. Naesens, J. Balzarini, E. Clercq, 1999 .

Expression analysis of the nucleocytoplasmic lectin ‘Orysata’ from rice in Pichia pastoris

David F. Smith, Yi Lasanajak, N. Callewaert, 2011, The FEBS journal.

David F. Smith, S. Savvides, P. Proost, 2009, Biochemical and biophysical research communications.

Synthesis of thiocarbohydrazide and carbohydrazide derivatives as possible biologically active agents

E. De Clercq, J. Balzarini, Kiran Gangarapu, 2013, Medicinal Chemistry Research.

Hairpin oligonucleotides forming G-quadruplexes: new aptamers with anti-HIV activity.

J. Balzarini, S. Noppen, S. Liekens, 2015, European journal of medicinal chemistry.

The DiPPro Approach: Synthesis, Hydrolysis, and Antiviral Activity of Lipophilic d4T Diphosphate Prodrugs

J. Balzarini, C. Meier, T. Schulz, 2014, ChemMedChem.

Curcumin-inspired cytotoxic 3,5-bis(arylmethylene)-1-(N-(ortho-substituted aryl)maleamoyl)-4-piperidones: A novel group of topoisomerase II alpha inhibitors.

H. Rupasinghe, K. S. Bhullar, A. Jha, 2015, Bioorganic & medicinal chemistry.

Design, synthesis and biological evaluation of 3-benzyloxy-linked pyrimidinylphenylamine derivatives as potent HIV-1 NNRTIs.

E. De Clercq, C. Pannecouque, P. Zhan, 2013, Bioorganic & medicinal chemistry.

Cyclo-saligenyl-5-fluoro-2′-deoxyuridinemonophosphate (cycloSal-FdUMP) — A New Prodrug Approach for FdUMP

J. Balzarini, M. Lorey, E. D. Clercq, 1997 .

Synthesis, and cytotoxic activity of N(ind)-alkoxy derivatives of antibiotic arcyriarubin and dechloro-rebeccamycin aglycon.

E. De Clercq, M. Preobrazhenskaya, J. Balzarini, 2002, The Journal of antibiotics.

Chemical modification of antibiotic streptonigrin; synthesis and properties of 2'-decarboxy-2'-aminostreptonigrin (streptonigrone-2'-imine).

E. De Clercq, V. Tolstikov, M. Preobrazhenskaya, 1992, The Journal of antibiotics.

Design, synthesis of new β-carboline derivatives and their selective anti-HIV-2 activity.

S. Chander, C. Pannecouque, J. Balzarini, 2015, Bioorganic & medicinal chemistry letters.

Cytotoxic 1,4-bis(2-oxo-1-cycloalkylmethylene)benzenes and related compounds.

E. De Clercq, J. Quail, J. Dimmock, 2002, European journal of medicinal chemistry.

6-Benzylidene-2-[4-(pyridin-3-ylcarboxy)benzylidene]cyclohexanones: A novel cluster of tumour-selective cytotoxins.

Stephen G. Dimmock, E. De Clercq, J. Dimmock, 2017, Bioorganic & medicinal chemistry letters.

Synthesis and Anti-HIV-1 Activity Evaluation of 5-Alkyl-2-alkylthio-6-(arylcarbonyl or α-cyanoarylmethyl)-3,4-dihydropyrimidin-4(3H)-ones as Novel Non-nucleoside HIV-1 Reverse Transcriptase Inhibitors

Jan Balzarini, Erik De Clercq, Christophe Pannecouque, 2007 .

Substrate Specificity of Three Viral Thymidine Kinases (TK): Vaccinia Virus TK, Feline Herpesvirus TK, and Canine Herpesvirus TK

J. Balzarini, A. Karlsson, M. Johansson, 2006, Nucleosides, Nucleotides & Nucleic Acids.

Optimization of xanthatin extraction from Xanthium spinosum L. and its cytotoxic, anti-angiogenesis and antiviral properties

M. Cascante, J. Balzarini, M. Zanuy, 2014, European Journal of Medicinal Chemistry.

Bis(benzoyloxybenzyl)‐DiPPro Nucleoside Diphosphates of Anti‐HIV Active Nucleoside Analogues

J. Balzarini, D. Schols, C. Meier, 2015, ChemMedChem.

Diffusion of Two Potential Anti-HIV Microbicides across Intact and De-Epithelialised, Human Vaginal Mucosa

J. Balzarini, J. V. van Zyl, D. Schols, 2008 .

A novel mannose-binding tuber lectin from Typhonium divaricatum (L.) Decne (family Araceae) with antiviral activity against HSV-II and anti-proliferative effect on human cancer cell lines.

J. Bao, J. Balzarini, E. V. Van Damme, 2007, Journal of biochemistry and molecular biology.

Exposure of HIV-1 to a combination of two carbohydrate-binding agents markedly delays drug resistance development and selects for virus strains with compromised fitness.

J. Balzarini, Leen Mathys, 2014, The Journal of antimicrobial chemotherapy.

In vitro synergistic activity against CCR5-tropic HIV-1 with combinations of potential candidate microbicide molecules HHA, KRV2110 and enfuvirtide (T20).

C. Charpentier, G. Vanham, J. Balzarini, 2009, The Journal of antimicrobial chemotherapy.

3,5‐Bis(benzylidene)‐4‐oxo‐1‐phosphonopiperidines and Related Diethyl Esters: Potent Cytotoxins with Multi‐Drug‐Resistance Reverting Properties

E. De Clercq, J. Molnár, J. Dimmock, 2009, ChemMedChem.

Synthesis, cytostatic and anti-viral activity evaluation of the novel acyclic nucleoside analogues containing a sterically constrained (Z)-4-amino-2-butenyl moiety

K. Pavelić, J. Balzarini, S. Kraljević Pavelić, 2010, Medicinal Chemistry Research.

Synthesis, characterization and anti-HIV activity of polycarboxylic [60]fullerene derivatives obtained in the reaction of C60Cl6 with a hydroquinone ether

P. Troshin, I. Godovikov, J. Balzarini, 2020 .

Highly selective reactions of C60Cl6 with thiols for the synthesis of functionalized [60]fullerene derivatives.

P. Troshin, J. Balzarini, S. Troyanov, 2012, Chemical communications.

Design, Synthesis, and Biological Evaluation of Novel 3,5‐Disubstituted‐1,2,6‐Thiadiazine‐1,1‐Dione Derivatives as HIV‐1 NNRTIs

Peng Zhan, Jan Balzarini, Ye Tian, 2013, Chemical biology & drug design.

Template Assisted Cyclotetramerisations of 1,2,5-Thiadiazole-3,4-dicarbonitrile.

E. Mørkved, F. Mo, U. Ragnarsson, 1994 .

The cytotoxic properties and preferential toxicity to tumour cells displayed by some 2,4-bis(benzylidene)-8-methyl-8-azabicyclo[3.2.1] octan-3-ones and 3,5-bis(benzylidene)-1-methyl-4-piperidones.

E. De Clercq, J. Quail, J. Dimmock, 2009, European journal of medicinal chemistry.

Total Synthesis of Acetylenic Carotenoids. 2. Synthesis of (all-E)-(3R,3'R)-Diatoxanthin and (all-E)-(3R)-7,8-Didehydrocryptoxanthin.

D. Aksnes, U. Ragnarsson, J. Balzarini, 1994 .

Synthesis and antiviral evaluation of C5-substituted-(1,3-diyne)-2'-deoxyuridines.

J. Balzarini, G. Andrei, R. Snoeck, 2012, European journal of medicinal chemistry.

2-Amino-3-methylcarboxy-5-heptyl-thiophene (TJ191) is a selective anti-cancer small molecule that targets low TβRIII-expressing malignant T-cell leukemia/lymphoma cells

W. Dehaen, J. Balzarini, S. Noppen, 2017, Oncotarget.

2-Alkoxycarbonyl-3-arylamino-5-substituted thiophenes as a novel class of antimicrotubule agents: Design, synthesis, cell growth and tubulin polymerization inhibition.

A. Brancale, G. Basso, G. Viola, 2018, European journal of medicinal chemistry.

Synthesis and cellular pharmacology studies of a series of 2-amino-3-aroyl-4-substituted thiophene derivatives.

Jan Balzarini, Roberto Gambari, Ernest Hamel, 2010, Medicinal chemistry (Shariqah (United Arab Emirates)).

Cytotoxic and Topographical Properties of 6-Arylidene-2-dimethylaminomethylcyclohexanone Hydrochlorides and Related Compounds

E. De Clercq, R. Sharma, J. Quail, 2004, Journal of enzyme inhibition and medicinal chemistry.

Chemo-Enzymatic Synthesis and Biological Evaluation of 5,6-Disubstituted Benzimidazole Ribo- and 2′-Deoxyribonucleosides

J. Balzarini, I. Konstantinova, V. Charushin, 2012 .

Sequential cytotoxicity: a theory evaluated using novel 2-[4-(3-aryl-2-propenoyloxy)phenylmethylene]cyclohexanones and related compounds.

E. De Clercq, J. Quail, J. Dimmock, 2000, Journal of medicinal chemistry.

SYNTHESIS AND CRYSTAL STRUCTURE OF NA3V(SO4)3. SPECTROSCOPIC CHARACTERIZATION OF NA3V(SO4)3 AND NAV(SO4)2

U. Ragnarsson, J. Balzarini, G. Francis, 1994 .

New Synthesis and Antitumor Activity of CycloSal- Derivatives of 5-Fluoro-2′-deoxyuridinemonophosphate

J. Balzarini, M. Lorey, E. D. Clercq, 1997 .

Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors. Part 11. Structural Modulations of Diaryltriazines with Potent anti-HIV Activity.

C. Pannecouque, J. Balzarini, Fener Chen, 2008 .

Synthesis and biological evaluation of piperidine-substituted triazine derivatives as HIV-1 non-nucleoside reverse transcriptase inhibitors.

Peng Zhan, Jan Balzarini, Xuwang Chen, 2012, European journal of medicinal chemistry.

Synthesis and Biological Evaluation of 2-Carbamoyl-5-D-Ribofuranosylpyridine

J. Balzarini, E. Clercq, E. Esmans, 1989 .

Antiviral and tumor cell antiproliferative SAR studies on tetracyclic eudistomins. II.

H. W. Scheeren, E. De Clercq, J. Balzarini, 1997, Bioorganic & medicinal chemistry.

Design, synthesis and biological evaluation of substituted guanidine indole derivatives as potential inhibitors of HIV-1 Tat-TAR interaction.

E. De Clercq, C. Pannecouque, P. Zhan, 2013, Medicinal chemistry.

Carbohydrate-binding agents (CBAs) inhibit HIV-1 infection in human primary monocyte-derived macrophages (MDMs) and efficiently prevent MDM-directed viral capture and subsequent transmission to CD4+ T lymphocytes.

J. Balzarini, D. Schols, E. V. Van Damme, 2008, Virology.

Bicyclic nucleoside inhibitors of Varicella-Zoster virus: the effect of branching in the p-alkylphenyl side chain.

E. De Clercq, J. Balzarini, C. Mcguigan, 2002, Bioorganic & medicinal chemistry letters.

The effect of (E)-5-(2-bromovinyl)-2'-deoxyuridine on DNA repair and mutagenesis of herpes simplex virus type 1.

C. Crumpacker, E. De Clercq, G. Bubley, 1987, Virology.

Synthesis and anti-HIV studies of 2- and 3-adamantyl-substituted thiazolidin-4-ones

J. Balzarini, J. Maurin, A. Orzeszko, 2008, European Journal of Medicinal Chemistry.

3′-(1,2,3-Triazol-1-yl)-2′,3′-dideoxythymidine and 3′-(1,2,3-Triazol-1-yl)-2′,3′-dideoxyuridine.

P. Herdewijn, A. Aerschot, J. Balzarini, 1990 .

In search of specific inhibitors of retrovirus replication.

E. De Clercq, J. Balzarini, 1985, Antiviral research.

Design and synthesis of α-carboxy phosphononucleosides.

A. Maguire, J. Balzarini, S. Debarge, 2011, The Journal of organic chemistry.

REVIEW Viruses as key regulators of angiogenesis

J. Balzarini, S. Liekens, P. Vervaeke, 2011 .

Fuchsin acid selectively inhibits human immunodeficiency virus (HIV) replication in vitro.

E. De Clercq, R. Pauwels, M. Baba, 1988, Biochemical and biophysical research communications.

Retinoic acid conjugates as potential antitumor agents: synthesis and biological activity of conjugates with Ara-A, Ara-C, 3(2H)-furanone, and aniline mustard moieties.

E. De Clercq, J. Balzarini, S. Manfredini, 1997, Journal of medicinal chemistry.

Design, synthesis, and cytostatic activity of novel cyclic curcumin analogues.

E. De Clercq, A. Jha, J. Balzarini, 2007, Bioorganic & medicinal chemistry letters.

Patient HIV-1 strains carrying the multiple nucleoside resistance mutations are cross-resistant to abacavir.

E. De Clercq, T. Harrer, B. Clotet, 2000, AIDS.

Synthesis of [11C]Cyanoalkylphosphoranes and their Use in the Preparation of 11C-Olefins.

B. Långström, U. Ragnarsson, J. Balzarini, 1994 .

A p-[18F]fluoroethoxyphenyl bicyclic nucleoside analogue as a potential positron emission tomography imaging agent for varicella-zoster virus thymidine kinase gene expression.

L. Mortelmans, G. Bormans, C. Deroose, 2007, Journal of Medicinal Chemistry.

Synthesis and biological evaluation of an 123I-labeled bicyclic nucleoside analogue (BCNA) as potential SPECT tracer for VZV-tk reporter gene imaging.

Zeger Debyser, Jan Balzarini, Luc Mortelmans, 2007, Bioorganic & Medicinal Chemistry Letters.

Synthesis and biological evaluation of a lipophilic, fluorine‐18‐labeled 5‐ethynyl‐2′‐deoxyuridine derivative

G. Bormans, A. Verbruggen, J. Balzarini, 2007 .

Glycan deletions in the HIV-1 gp120 V1/V2 domain compromise viral infectivity, sensitize the mutant virus strains to carbohydrate-binding agents and represent a specific target for therapeutic intervention.

K. Van Laethem, J. Balzarini, K. François, 2008, Virology.

Differential inhibitory effects of sulfated polysaccharides on the replication of various myxo- and retroviruses

M. Hosoya, J. Balzarini, E. Clercq, 1991 .

Pronounced anti-proliferative activity and tumor cell selectivity of 5-alkyl-2-amino-3-methylcarboxylate thiophenes.

E. Vanstreels, W. Dehaen, J. Balzarini, 2017, European journal of medicinal chemistry.

Knocking-out concentrations of HIV-1-specific inhibitors completely suppress HIV-1 infection and prevent the emergence of drug-resistant virus.

E. De Clercq, J. Balzarini, A. Karlsson, 1993, Virology.

Microwave Assisted Synthesis, Characterization of Some New Isatin and Thiophene Derivatives as Cytotoxic and Chemopreventive Agents

J. Balzarini, E. Clercq, Kiran Gangarapu, 2012 .

Synthesis, DNA binding, and biological evaluation of synthetic precursors and novel analogues of netropsin.

E. De Clercq, C. Paoletti, J. Balzarini, 1989, Journal of medicinal chemistry.

Deletion of the Highly Conserved N-Glycan at Asn260 of HIV-1 gp120 Affects Folding and Lysosomal Degradation of gp120, and Results in Loss of Viral Infectivity

Jan Balzarini, I. Braakman, J. Balzarini, 2014, PloS one.

Design and synthesis of a new series of cyclopropylamino-linking diarylpyrimidines as HIV non-nucleoside reverse transcriptase inhibitors.

E. De Clercq, C. Pannecouque, J. Balzarini, 2014, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Design and synthesis of a new series of modified CH-diarylpyrimidines as drug-resistant HIV non-nucleoside reverse transcriptase inhibitors.

E. De Clercq, C. Pannecouque, J. Balzarini, 2014, European journal of medicinal chemistry.

All trans 1-(3-arylacryloyl)-3,5-bis(pyridin-4-ylmethylene)piperidin-4-ones as curcumin-inspired antineoplastics.

H. Rupasinghe, K. S. Bhullar, A. Jha, 2014, European journal of medicinal chemistry.

Synthesis and Biological Evaluation of 4-Carbamoyl-2-β-D-Ribofuranosyl-Pyridine

J. Balzarini, E. Clercq, R. Dommisse, 1991 .

Metabolism of EICAR (5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide), a potent inhibitor of inosinate dehydrogenase.

E. De Clercq, A. Matsuda, J. Balzarini, 1997, Advances in experimental medicine and biology.

Synthesis and Biological Evaluation of Novel 1′‐Branched and Spironucleosides Analogues.

J. Balzarini, E. Clercq, C. Chatgilialoglu, 2005 .

Eicar (5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide). A novel potent inhibitor of inosinate dehydrogenase activity and guanylate biosynthesis.

E. De Clercq, P. Herdewijn, J. Balzarini, 1993, The Journal of biological chemistry.

Establishment of a bioassay to determine serum levels of dextran sulfate and pentosan polysulfate, two potent inhibitors of human immunodeficiency virus.

E. De Clercq, R. Pauwels, M. Baba, 1990, Journal of acquired immune deficiency syndromes.

Differences in the mannose oligomer specificities of the closely related lectins from Galanthus nivalis and Zea mays strongly determine their eventual anti-HIV activity

K. Van Laethem, P. Rougé, J. Balzarini, 2011, Retrovirology.

Capture and transmission of HIV-1 by the C-type lectin L-SIGN (DC-SIGNR) is inhibited by carbohydrate-binding agents and polyanions.

E. Vanstreels, K. Van Laethem, J. Balzarini, 2009, Antiviral research.

Role of the Carbohydrate-Binding Sites of Griffithsin in the Prevention of DC-SIGN-Mediated Capture and Transmission of HIV-1

J. Balzarini, B. Hoorelbeke, P. LiWang, 2013, PloS one.

In vitro Activity of Polyhydroxycarboxylates against Herpesviruses and Hiv

E. De Clercq, J. Neyts, J. Balzarini, 2001, Antiviral chemistry & chemotherapy.

Acyclic/Carbocyclic Guanosine Analogues as Anti‐Herpesvirus Agents

L. Naesens, B. Degrève, J. Balzarini, 2001 .

The molecular basis of resilience to the effect of the Lys103Asn mutation in non-nucleoside HIV-1 reverse transcriptase inhibitors studied by targeted molecular dynamics simulations.

Jan Balzarini, Federico Gago, F. Gago, 2005, Journal of the American Chemical Society.

Symmetrical Diamidates as a Class of Phosphate Prodrugs to Deliver the 5′‐Monophosphate Forms of Anticancer Nucleoside Analogues

J. Balzarini, C. Mcguigan, Valentina Ferrari, 2018, ChemMedChem.

Exploring the purine core of 3′-C-ethynyladenosine (EAdo) in search of novel nucleoside therapeutics

S. van Calenbergh, J. Balzarini, D. Schols, 2016, Bioorganic & Medicinal Chemistry Letters.

Can positron emission tomography with [18F]

P. Dupont, L. Mortelmans, S. Stroobants, 2001 .

Synthesis and antiviral activity of three pyrazole analogues of distamycin A.

E. De Clercq, U. Ragnarsson, J. Balzarini, 1994, Acta chemica Scandinavica.

Molecular cloning of the lectin and a lectin-related protein from common Solomon's seal (Polygonatum multiflorum)

P. Rougé, F. Leuven, J. Balzarini, 1996, Plant Molecular Biology.

The monomeric and dimeric mannose-binding proteins from the Orchidaceae speciesListera ovata andEpipactis helleborine: sequence homologies and differences in biological activities

F. Leuven, J. Balzarini, W. Peumans, 1994, Glycoconjugate Journal.

Synthesis and Biological Evaluation of 2-(2-Deoxy-β-D- ribofuranosyl)pyridine-4-carboxamide.

J. Balzarini, R. Dommisse, E. Esmans, 1992 .

Nucleoside and nucleotide reverse transcriptase inhibitors

J. Balzarini, E. Clercq, 2001 .

The role of N-glycans of HIV-1 gp41 in virus infectivity and susceptibility to the suppressive effects of carbohydrate-binding agents

J. Balzarini, Leen Mathys, 2014, Retrovirology.

Enhanced toxicity of purine nucleoside analogs in cells expressing Drosophila melanogaster nucleoside kinase mutants

J. Balzarini, A. Karlsson, M. Johansson, 2007, Gene Therapy.

Phosphorylation of 9-(2-phosphonyimethoxyethyl)adenine (PMEA) is greater in macrophages than in replicating lymphocytes and fibroblasts

C. Perno, J. Balzarini, S. Aquaro, 1995 .

Synthesis and antiviral activity evaluation of some novel acyclic C-nucleosides.

J. Balzarini, P. Marakos, N. Pouli, 2008, Chemical & pharmaceutical bulletin.

Structural modification of diarylpyrimidine derivatives as HIV-1 reverse transcriptase inhibitors

C. Pannecouque, J. Balzarini, E. Clercq, 2014, Medicinal Chemistry Research.

Non‐nucleoside HIV Reverse Transcriptase Inhibitors, Part 6[1]: Synthesis and Anti‐HIV Activity of Novel 2‐[(Arylcarbonylmethyl)thio]‐6‐arylthio DABO Analogues

E. De Clercq, C. Pannecouque, J. Balzarini, 2005, Archiv der Pharmazie.

Non‐nucleoside HIV Reverse Transcriptase Inhibitors. Part 6. Synthesis and Anti‐HIV Activity of Novel 2‐[(Arylcarbonylmethyl)thio]‐6‐arylthio DABO Analogues.

E. De Clercq, C. Pannecouque, J. Balzarini, 2006 .

Application of phosphoramidate ProTide technology significantly improves antiviral potency of carbocyclic adenosine derivatives.

T. Burnette, J. Balzarini, C. Mcguigan, 2006, Journal of medicinal chemistry.

Biochemical pharmacology of nucleoside analogues active against HIV

J. Balzarini, E. Clercq, 1994 .

1-Aryl-2-dimethylaminomethyl-2-propen-1-one hydrochlorides and related adducts: A quest for selective cytotoxicity for malignant cells.

E. De Clercq, J. Dimmock, J. Balzarini, 2008, Bioorganic & medicinal chemistry.

Rapid alternation of drug therapy is highly efficient in suppressing the emergence of mutant drug-resistant HIV strains in cell culture.

E. De Clercq, J. Balzarini, 2001, AIDS research and human retroviruses.

Combination of antiretroviral drugs as microbicides.

J. Balzarini, D. Schols, 2012, Current HIV research.

92 Ara-A-5′-phenyl methoxy alaninyl phosphate as a prodrug of the adenine arabinoside -monophosphate: synthesis and anti viral evaluation

J. Balzarini, E. Clercq, C. Mcguigan, 2000 .

Cyclo-Saligenyl-3′-Azido-2′,3′-Dideoxy- Thymidinemonophosphate (cycloSal-AZTMP) - A New Pro-Nucleotide Approach1 ?-

J. Balzarini, E. D. Clercq, C. Meiera, 1997 .

Synthesis and Antitumor Properties of Some Neutral Triesters of 5-Fluoro-2′-deoxyuridine-5′-monophosphate and 3′,5′-Cyclic Monophosphate

J. Balzarini, E. Clercq, J. Imbach, 1995 .

Mechanism of Anti-HIV Action of Masked Alaninyl 2 ,3 -Dideoxy-2 ,3 -Didehydrothymidine 5 -Monophosphate Derivatives

L. Naesens, C. Perno, J. Balzarini, 1996 .

Therapeutic potential of PMEA as an antiviral drug

E. De Clercq, L. Naesens, J. Balzarini, 1994 .

Prodrogues de vih clivables par cd26

J. Balzarini, P. Wigerinck, H. D. Kock, 2004 .

cyclo-Saligenyl-3′-azido-2′,3′-dideoxy-thymidinemonophosphate ( cycloSal-AZTMP) - A New Pro-Nucleotide Approach?

J. Balzarini, E. D. Clercq, C. Meier, 1997 .

Regioselective Addition Reactions at C-2 of 3,4-Dihydropyrimidinones. Synthesis and Evaluation of Multifunctionalized Tetrahydropyrimidines.

D. Arora, J. Balzarini, Kamaljit Singh, 2011 .

Novel series of [ddN]-[TSAO-T] heterodimers as potential bi-functional inhibitors of HIV-1 RT. Studies in the linker and ddN region.

E. De Clercq, A. Esteban-Gamboa, J. Balzarini, 1999, Nucleosides and Nucleotides.

Profile of Resistance of Human Immunodeficiency Virus to Mannose-Specific Plant Lectins

E. De Clercq, A. Vandamme, K. Van Laethem, 2004, Journal of Virology.

Chlorofullerene C60Cl6: a precursor for straightforward preparation of highly water-soluble polycarboxylic fullerene derivatives active against HIV.

Jan Balzarini, P. Troshin, J. Balzarini, 2007, Organic and biomolecular chemistry.

Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds.

E. De Clercq, L. Naesens, J. Neyts, 2007, Journal of medicinal chemistry.

Tumour-specific cytotoxicity and structure-activity relationships of novel 1-[3-(2-methoxyethylthio)propionyl]-3,5-bis(benzylidene)-4-piperidones.

E. De Clercq, J. Dimmock, J. Balzarini, 2016, Bioorganic & medicinal chemistry.

3,5-Bis(benzylidene)-1-[3-(2-hydroxyethylthio)propanoyl]piperidin-4-ones: a novel cluster of potent tumor-selective cytotoxins.

Jan Balzarini, Hiroshi Sakagami, E. De Clercq, 2011, Journal of medicinal chemistry.

Correction to Conformational States of HIV-1 Reverse Transcriptase for Nucleotide Incorporation vs Pyrophosphorolysis-Binding of Foscarnet.

Jan Balzarini, Matthew T Miller, Eddy Arnold, 2016, ACS Chemical Biology.

Marked inhibitory activity of non-nucleoside reverse transcriptase inhibitors against human immunodeficiency virus type 1 when combined with (-)2',3'-dideoxy-3'-thiacytidine.

E. De Clercq, J. Balzarini, A. Karlsson, 1996, Molecular pharmacology.

Design, synthesis and preliminary SAR studies of novel N-arylmethyl substituted piperidine-linked aniline derivatives as potent HIV-1 NNRTIs.

Peng Zhan, Jan Balzarini, Xuwang Chen, 2014, Bioorganic & medicinal chemistry.

1-Arylmethyl-2,3-dioxo-2,3-dihydroindole thiosemicarbazones as leads for developing cytotoxins and anticonvulsants

E. De Clercq, J. Dimmock, J. Balzarini, 2009, Journal of enzyme inhibition and medicinal chemistry.

Synthesis, antifungal, antibacterial and antiviral effects of some adamantaneketoxime ethers.

E. De Clercq, M. Hosoya, J. Balzarini, 1993, Farmaco.

Long-Lasting Enfuvirtide Carrier Pentasaccharide Conjugates with Potent Anti-Human Immunodeficiency Virus Type 1 Activity

L. Vincent, J. Balzarini, D. Schols, 2009, Antimicrobial Agents and Chemotherapy.

Antiviral effect of plant compounds of the Alliaceae family against the SARS coronavirus

J. Balzarini, E. Clercq, W. Peumans, 2004 .

Inhibitory activity of vancomycin, eremomycin and teicoplanin aglycon derivatives against feline and human coronaviruses (i.e. SARS)

M. Preobrazhenskaya, J. Balzarini, E. Clercq, 2004 .

Mannose-specific plant lectins are potent inhibitors of coronavirus infection including the virus causing SARS

J. Balzarini, E. Clercq, H. Egberink, 2004 .

Reaction of the antitumor antibiotic olivomycin I with aryl diazonium salts. Synthesis, cytotoxic and antiretroviral potency of 5-aryldiazenyl-6-O-deglycosyl derivatives of olivomycin I.

M. Preobrazhenskaya, J. Balzarini, A. Shtil, 2009, Bioorganic & medicinal chemistry.

Modification of the antibiotic olivomycin I at the 2′-keto group of the side chain. Novel derivatives, antitumor and topoisomerase I-poisoning activity

M. Preobrazhenskaya, J. Balzarini, A. Shtil, 2009, The Journal of Antibiotics.

Synthesis and biological evaluation of pyridazine derivatives as novel HIV-1 NNRTIs.

Peng Zhan, Jan Balzarini, Christophe Pannecouque, 2013, Bioorganic & medicinal chemistry.

Novel piperidinylamino-diarylpyrimidine derivatives with dual structural conformations as potent HIV-1 non-nucleoside reverse transcriptase inhibitors.

E. De Clercq, Huiqing Liu, C. Pannecouque, 2013, Bioorganic & medicinal chemistry letters.

New Sorafenib Derivatives: Synthesis, Antiproliferative Activity Against Tumour Cell Lines and Antimetabolic Evaluation

M. Kralj, J. Vanderleyden, J. Balzarini, 2012, Molecules.

Potentiating effect of ribavirin on the in vitro and in vivo antiretrovirus activities of 2',3'-dideoxyinosine and 2',3'-dideoxy-2,6-diaminopurine riboside.

E. De Clercq, L. Naesens, J. Balzarini, 1990, Journal of acquired immune deficiency syndromes.

The α(1,2)‐mannosidase I inhibitor 1‐deoxymannojirimycin potentiates the antiviral activity of carbohydrate‐binding agents against wild‐type and mutant HIV‐1 strains containing glycan deletions in gp120

J. Balzarini, 2007, FEBS Letters.

NUCLEOSIDES, NUCLEOTIDES & NUCLEIC ACIDS

C. Pannecouque, J. Balzarini, E. Clercq, 2004 .

Thermal characterization of the antiviral drug UC-781 and stability of its glass

Lieve Naesens, Jan Balzarini, Patrick Augustijns, 2001 .

Synthesis and Cytotoxic Evaluation of Some Carbohydrazones and Thiocarbohydrazones of Various Unsaturated Ketones and Related Mannich Bases.

J. Dimmock, J. Balzarini, G. Kao, 1997 .

The Phthalocyanine Prototype Derivative Alcian Blue Is the First Synthetic Agent with Selective Anti-Human Immunodeficiency Virus Activity Due to Its gp120 Glycan-Binding Potential

C. Pannecouque, J. Balzarini, D. Schols, 2009, Antimicrobial Agents and Chemotherapy.

Prognostic value of positron emission tomography (PET) with fluorine-18 fluorodeoxyglucose ([18f]FDG) after first-line chemotherapy in non-Hodgkin's lymphoma : Is [18F]FDG-PET a valid alternative to conventional diagnostic methods?

P. Dupont, L. Mortelmans, G. Bormans, 2001 .

Synthesis and antiviral activity of 5'-deoxypyrazofurin.

E. De Clercq, S. Ikeda, J. Balzarini, 1993, Journal of medicinal chemistry.

Synthesis and biological properties of 2'-substituted 2',3'-dideoxy-3'-fluoro-D-ribonucleosides

J. Balzarini, E. Clercq, N. Poopeiko, 1990 .

Intravaginal and intrarectal microbicides to prevent HIV infection

L. van Damme, J. Balzarini, 2005, Canadian Medical Association Journal.

Studies on the Gas-Phase Electron Diffraction Data of Tungsten Hexachloride and Lead Tetrachloride in View of Digital Fourier Filtering, Three-Atom Scattering and Accuracy of Scattering Functions.

M. Leskelä, U. Ragnarsson, J. Balzarini, 1994 .

Antiproliferative activities of halogenated pyrrolo[3,2-d]pyrimidines.

G. M. Wilson, J. Balzarini, Christina R. Ross, 2015, Bioorganic & medicinal chemistry.

Indolylarylsulfones as HIV-1 non-nucleoside reverse transcriptase inhibitors: new cyclic substituents at the indole-2-carboxamide

E. Novellino, A. Coluccia, A. Brancale, 2011 .

Antiviral profile of HIV inhibitors in macrophages: implications for therapy.

J. Balzarini, S. Aquaro, C. Perno, 2004, Current topics in medicinal chemistry.

Prodrugs of Ara-CMP and Ara-AMP with a S-acyl-2-thioethyl (SATE) biolabile phosphate protecting group: synthesis and biological evaluation.

E. De Clercq, J. Balzarini, J. Imbach, 1999, Nucleosides & nucleotides.

Diastereoselective Synthesis of (Aryloxy)phosphoramidate Prodrugs

J. Balzarini, C. Meier, C. A. Román, 2011 .

Synthesis and biological evaluation of 4-(hydroxyimino)arylmethyl diarylpyrimidine analogues as potential non-nucleoside reverse transcriptase inhibitors against HIV.

E. De Clercq, C. Pannecouque, J. Balzarini, 2010, Bioorganic & Medicinal Chemistry.

Synthesis and anti-HIV-1 activity evaluation of 5-alkyl-2-alkylthio-6-(arylcarbonyl or alpha-cyanoarylmethyl)-3,4-dihydropyrimidin-4(3H)-ones as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.

E. De Clercq, C. Pannecouque, J. Balzarini, 2007, Journal of medicinal chemistry.

Nebrodeolysin, a novel hemolytic protein from mushroom Pleurotus nebrodensis with apoptosis-inducing and anti-HIV-1 effects.

J. Bao, J. Balzarini, E. V. Van Damme, 2009, Phytomedicine : international journal of phytotherapy and phytopharmacology.

S. D. De Keersmaecker, A. De Weerdt, J. Vanderleyden, 2010, Bioorganic & medicinal chemistry.

Discovery of Piperidine‐Linked Pyridine Analogues as Potent Non‐nucleoside HIV‐1 Reverse Transcriptase Inhibitors

Huiqing Liu, C. Pannecouque, Xinyong Liu, 2013, ChemMedChem.

Structural Modifications of DAPY Analogues with Potent Anti‐HIV‐1 Activity

C. Pannecouque, J. Balzarini, Fener Chen, 2009, ChemMedChem.

Synthesis of thiocarbohydrazide and carbohydrazide derivatives as possible biologically active agents

E. De Clercq, J. Balzarini, Kiran Gangarapu, 2013, Medicinal Chemistry Research.

The cytostatic activity of NUC-3073, a phosphoramidate prodrug of 5-fluoro-2'-deoxyuridine, is independent of activation by thymidine kinase and insensitive to degradation by phosphorolytic enzymes.

J. Balzarini, S. Liekens, Magdalena Ślusarczyk, 2011, Biochemical pharmacology.

Antiproliferative activity, mechanism of action and oral antitumor activity of CP-4126, a fatty acid derivative of gemcitabine, in in vitro and in vivo tumor models

G. Peters, I. Fichtner, A. Bergman, 2010, Investigational New Drugs.

Microbicide drug candidates to prevent HIV infection

J. Balzarini, L. Damme, 2007, The Lancet.

Inhibition of Cell-to-Cell Transmission of Human T-Cell Lymphotropic Virus Type 1 In Vitro by Carbohydrate-Binding Agents

J. Balzarini, Y. Igarashi, T. Oki, 2008, Antimicrobial Agents and Chemotherapy.

Chemotherapy of human immunodeficiency virus by pradimicin A: a novel therapeutic concept for treatment of glycosylated enveloped viruses

C. Perno, J. Balzarini, D. Schols, 2006 .

Uracil derivatives and analogues .24. Palladium-catalyzed synthesis of [E]-6-(2-acylvinyl)uracils and [E]-6-(2-acylvinyl)-1-[(2-hydroxyethoxy)methyl]uracils - their antiviral and cytotoxic activities

J. Balzarini, N. Kundu, E. D. Clercq, 1997 .

Antiproliferative and Antiviral Activity of Three Libraries of Adamantane Derivatives

E. De Clercq, J. Balzarini, N. Basarić, 2014, Archiv der Pharmazie.

Alkyloxyphenyl Furano Pyrimidines as Potent and Selective Anti-VZV Agents with Enhanced Water Solubility

J. T. Erichsen, E. De Clercq, J. Balzarini, 2002, Antiviral chemistry & chemotherapy.

Bicyclic Nucleoside Inhibitors of Varicella-Zoster Virus (VZV): Pd-Catalysed Synthesis of 5-aryl Derivatives and Their Biological Evaluation

J. Balzarini, G. Andrei, R. Snoeck, 2001, Antiviral chemistry & chemotherapy.

Novel carbocyclic nucleosides containing a cyclobutyl ring. Guanosine and adenosine analogues.

E. De Clercq, J. Balzarini, G. Andrei, 1998, Nucleosides & nucleotides.

Inhibition of infection and transmission of HIV-1 and lack of significant impact on the vaginal commensal lactobacilli by carbohydrate-binding agents.

S. Lebeer, J. Vanderleyden, J. Balzarini, 2013, The Journal of antimicrobial chemotherapy.

Improvement of purine and pyrimidine antimetabolite-based anticancer treatment by selective suppression of mycoplasma-encoded catabolic enzymes.

J. Balzarini, A. Bronckaers, S. Liekens, 2009, The Lancet. Oncology.

Synthesis, anti-HIV-1 activity, and modeling studies of N-3 Boc TSAO compound.

E. De Clercq, C. Pannecouque, J. Balzarini, 2008, Bioorganic & medicinal chemistry letters.

Synthesis and preliminary evaluation of 18F- or 11C-labeled bicyclic nucleoside analogues as potential probes for imaging varicella-zoster virus thymidine kinase gene expression using positron emission tomography.

L. Mortelmans, G. Bormans, T. D. de Groot, 2007, Journal of medicinal chemistry.

Long-Lasting Enfuvirtide Carrier Pentasaccharide Conjugates with Potent Anti-Human Immunodeficiency Virus Type 1 Activity

L. Vincent, J. Balzarini, D. Schols, 2009, Antimicrobial Agents and Chemotherapy.

Inhibitory activity of diarylamidine derivatives on murine leukemia L1210 cell growth

J. Balzarini, E. Clercq, O. Dann, 2004, Investigational New Drugs.

Synthesis of New Cyclic and Acyclic 5-Halouridine Derivatives as Potential Antiviral Agents

J. Balzarini, C. Meier, Mohamed F. Elshehry, 2009 .

Design, synthesis, antiviral and cytostatic evaluation of novel isoxazolidine nucleotide analogues with a 1,2,3-triazole linker

J. Balzarini, D. Piotrowska, I. Głowacka, 2011, European Journal of Medicinal Chemistry.

Exposure of HIV-1 to a combination of two carbohydrate-binding agents markedly delays drug resistance development and selects for virus strains with compromised fitness.

J. Balzarini, Leen Mathys, 2014, The Journal of antimicrobial chemotherapy.

Photosensitizers mediated photodynamic inactivation against virus particles.

J. Balzarini, J. Mielcarek, L. Sobotta, 2015, Mini reviews in medicinal chemistry.

Novel concepts in the treatment of human immunodeficiency virus type 1 (HIV-1) infections by HIV-1-specific reverse transcriptase inhibitors.

J. Balzarini, 1995, Verhandelingen - Koninklijke Academie voor Geneeskunde van Belgie.

A new class of HIV-1-specific 6-substituted acyclouridine derivatives: synthesis and anti-HIV-1 activity of 5- or 6-substituted analogues of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT).

S Shigeta, H. Hayakawa, M. Baba, 1991, Journal of medicinal chemistry.

Phosphorylation of dGMP analogs by vaccinia virus TMP kinase and human GMP kinase.

H. Munier-Lehmann, Constance Auvynet, J. Balzarini, 2009, Biochemical and biophysical research communications.

A new four-component reaction involving the Michael addition and the Gewald reaction, leading to diverse biologically active 2-aminothiophenes.

W. Dehaen, J. Balzarini, S. Liekens, 2017, Organic & biomolecular chemistry.

Design, synthesis, structure-activity relationships, and molecular modeling studies of 2,3-diaryl-1,3-thiazolidin-4-ones as potent anti-HIV agents.

Jan Balzarini, Laura De Luca, Maria Zappalà, 2002, Journal of medicinal chemistry.

Synthesis and Antiviral Activities of Some New 5-Heteroaromatic Substituted Derivatives of 2′-Deoxyuridine

C. Pannecouque, P. Herdewijn, A. Aerschot, 1995 .

Synthesis and biological evaluation of iodinated and fluorinated 9-(2-hydroxypropyl) and 9-(2-hydroxyethoxy)methyl purine nucleoside analogues.

E. De Clercq, G. Folkers, L. Scapozza, 2003, Journal of Medicinal Chemistry.

Partial purification and characterization of mitochondrial DNA polymerase from Plasmodium falciparum.

L. Naesens, P. Wilairat, P. Chavalitshewinkoon-Petmitr, 2000, Parasitology international.

3',3'-Difluoro-3'-deoxythymidine: comparison of anti-HIV activity to 3'-fluoro-3'-deoxythymidine.

E. De Clercq, J. Balzarini, D. Bergstrom, 1992, Journal of medicinal chemistry.

The Griffithsin Dimer Is Required for High-Potency Inhibition of HIV-1: Evidence for Manipulation of the Structure of gp120 as Part of the Griffithsin Dimer Mechanism

J. Balzarini, B. Demeler, P. LiWang, 2013, Antimicrobial Agents and Chemotherapy.