C. Dunbar

Xingmin Feng, N. Young, J. Maciejewski, 2010, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

Donor demographic and laboratory predictors of allogeneic peripheral blood stem cell mobilization in an ethnically diverse population.

A. Barrett, M. Bishop, J. Tisdale, 2008, Blood.

Plasticity and hematopoiesis: Circe's transforming potion?

J. Tisdale, C. Dunbar, 2002, Current opinion in hematology.

Rapid mobilization of hematopoietic progenitors by AMD3100 and catecholamines is mediated by CXCR4-dependent SDF-1 release from bone marrow stromal cells

E. Buss, P. Frenette, H. Broxmeyer, 2011, Leukemia.

BM-derived cell therapies for cardiovascular disease.

R. Cannon, C. Dunbar, 2007, Cytotherapy.

Human thrombopoietin levels are high when thrombocytopenia is due to megakaryocyte deficiency and low when due to increased platelet destruction.

N. Young, R. Cohen, C. Dunbar, 1996, Blood.

Clonal hematopoiesis is not significantly associated with COVID-19 disease severity

F. Rieux-Laucat, L. Notarangelo, K. Dobbs, 2022, Blood.

Growth factors and stromal support generate very efficient retroviral transduction of peripheral blood CD34+ cells from Gaucher patients.

R. Schiffmann, S. Karlsson, C. Dunbar, 1995, Blood.

Retroviral-mediated gene transfer into CD34-enriched human peripheral blood stem cells.

C. Dunbar, M. Cottler-Fox, S. Doren, 1993, Experimental hematology.

Improved engraftment of human hematopoietic cells in severe combined immunodeficient (SCID) mice carrying human cytokine transgenes

D. Bodine, T. Bock, H. Broxmeyer, 1995, The Journal of experimental medicine.

707. Retroviral insertion site analysis in rhesus macaques transplanted with CD34+ hematopoietic stem cells transduced with a simian immunodeficiency virus-based lentiviral vector

A. Nienhuis, J. Gray, C. Dunbar, 2004 .

HEMATOPOIETIC STEM CELL GENE THERAPY: ASSESSING THE RELEVANCE OF PRE-CLINICAL MODELS

C. Dunbar, A. Larochelle, 2013 .

Genetic marking as an approach to studying in vivo hematopoiesis: progress in the non-human primate model

C. Dunbar, P. Hematti, C. Kalle, 2002, Oncogene.

Thrombopoietic status of patients on haemodialysis

Xingmin Feng, C. Dunbar, Samir H. Patel, 2016, British journal of haematology.

Ex vivo expansion of genetically marked rhesus peripheral blood progenitor cells results in diminished long-term repopulating ability.

J. Tisdale, Y. Hanazono, C. Dunbar, 1998, Blood.

Retroviral marking and transplantation of rhesus hematopoietic cells by nonmyeloablative conditioning.

J. Tisdale, C. Dunbar, R. Donahue, 1999, Human gene therapy.

Keratinocyte growth factor augments immune reconstitution after autologous hematopoietic progenitor cell transplantation in rhesus macaques.

K. Camphausen, S. Pittaluga, M. Meier-Schellersheim, 2007, Blood.

Glucocorticoid-induced eosinopenia results from CXCR4-dependent bone marrow migration.

P. Choyke, Zonghui Hu, C. Dunbar, 2020, Blood.

Predictors of clonal evolution and myeloid neoplasia following immunosuppressive therapy in severe aplastic anemia

K. Calvo, C. Dunbar, Fernanda Gutierrez-Rodrigues, 2022, Leukemia.

Hematopoietic Stem Cell Behavior in Non-human Primates

Abkowitz, P. Guttorp, P. Lansdorp, 2007 .

Retroviral mediated transfer of the cDNA for human glucocerebrosidase into hematopoietic stem cells of patients with Gaucher disease. A phase I study.

C. Dunbar, D. Kohn, 1996, Human gene therapy.

Retroviral mediated transfer of the human multidrug resistance gene (MDR-1) into hematopoietic stem cells during autologous transplantation after intensive chemotherapy for metastatic breast cancer.

W. Wilson, I. Pastan, M. Gottesman, 1994, Human gene therapy.

Imatinib-Responsive Hypereosinophilia in a Patient with B Cell ALL

D. Arthur, T. Nutman, C. Dunbar, 2004, Leukemia & lymphoma.

In vivo marking of rhesus monkey lymphocytes by adeno-associated viral vectors: direct comparison with retroviral vectors.

Y. Hanazono, C. Dunbar, R. Donahue, 1999, Blood.

Prolonged multilineage clonal hematopoiesis in a rhesus recipient of CD34 positive cells marked with a RD114 pseudotyped oncoretroviral vector.

Jody A. Vandergriff, A. Nienhuis, C. Dunbar, 2003, Blood cells, molecules & diseases.

Transient in vivo selection of transduced peripheral blood cells using antifolate drug selection in rhesus macaques transplanted with hematopoietic stem cells expressing dihydrofolate reductase vectors

T. Lu, J. Allay, C. Dunbar, 2003 .

Retroviral transduction of CD34-enriched hematopoietic progenitor cells under serum-free conditions.

C. Dunbar, H. Kotani, G. McGarrity, 1996, Human gene therapy.

Combination therapy with rFVIIa and platelets for hemorrhage in patients with severe thrombocytopenia and alloimmunization

C. Dunbar, B. Savani, M. Rick, 2006, American journal of hematology.

Long‐term eltrombopag for bone marrow failure depletes iron

K. Calvo, C. Dunbar, A. Larochelle, 2022, American journal of hematology.

efficacy of gene therapy in older SCID-X1 patients Old before its time: age-related thymic dysfunction may preclude

C. Dunbar, R. Seggewiss, 2013 .

Repetitive busulfan administration after hematopoietic stem cell gene therapy associated with a dominant HDAC7 clone in a nonhuman primate.

C. Dunbar, R. Donahue, A. Larochelle, 2010, Human gene therapy.

Gene therapy activates EVI1, destabilizes chromosomes

C. Dunbar, A. Larochelle, 2010, Nature Medicine.

Hematopoietic stem cell gene therapy: dead or alive?

C. Dunbar, A. Larochelle, Cole Ferguson, 2005, Trends in biotechnology.

Large Animal Models for Stem and Progenitor Cell Analysis

C. Dunbar, R. Donahue, K. Kuramoto, 2005, Current protocols in immunology.

A new direction for gene therapy: intrathymic T cell-specific lentiviral gene transfer.

C. Dunbar, R. Seggewiss, 2005, The Journal of clinical investigation.

Old before its time: age-related thymic dysfunction may preclude efficacy of gene therapy in older SCID-X1 patients

C. Dunbar, R. Seggewiss, 2005 .

Long-term clinical and molecular follow-up of large animals receiving retrovirally transduced stem and progenitor cells: no progression to clonal hematopoiesis or leukemia.

C. von Kalle, A. Nienhuis, C. A. Blau, 2004, Molecular therapy : the journal of the American Society of Gene Therapy.

Rabaptin-5 is a novel fusion partner to platelet-derived growth factor beta receptor in chronic myelomonocytic leukemia.

M. K. Magnússon, A. Barrett, D. Arthur, 2001, Blood.

Applying a clinical lens to animal models of CAR-T cell therapies

C. Dunbar, Brynn B. Duncan, Kazusa Ishii, 2022, Molecular therapy. Methods & clinical development.

Separating the wheat from the chaff: selection of benign hematopoietic cells in chronic myeloid leukemia.

C. Dunbar, F. Stewart, F., 1992, Blood.

Long-term in vivo expression of the human glucocerebrosidase gene in nonhuman primates after CD34+ hematopoietic cell transduction with cell-free retroviral vector preparations.

S. Karlsson, R. Brady, C. Dunbar, 1995, Proceedings of the National Academy of Sciences of the United States of America.

The effect of multidrug-resistance 1 gene versus neo transduction on ex vivo and in vivo expansion of rhesus macaque hematopoietic repopulating cells.

J. Tisdale, C. Dunbar, R. Donahue, 2001, Blood.

Thymidine kinase suicide gene-mediated ganciclovir ablation of autologous gene-modified rhesus hematopoiesis.

F. Marini, C. Dunbar, R. Donahue, 2012, Molecular therapy : the journal of the American Society of Gene Therapy.

Ex vivo expansion of retrovirally transduced primate CD34+ cells results in overrepresentation of clones with MDS1/EVI1 insertion sites in the myeloid lineage after transplantation.

R. Childs, C. Dunbar, R. Donahue, 2010, Molecular therapy : the journal of the American Society of Gene Therapy.

Recurrent retroviral vector integration at the Mds1/Evi1 locus in nonhuman primate hematopoietic cells.

C. von Kalle, M. Laukkanen, C. Dunbar, 2005, Blood.

Gene transfer to hematopoietic stem cells: implications for gene therapy of human disease.

C. Dunbar, Cynthia E. Dunbar, M.D, 1996, Annual review of medicine.

Molecular and serological examination of the relationship of human herpesvirus 8 to multiple myeloma: orf 26 sequences in bone marrow stroma are not restricted to myeloma patients and other regions of the genome are not detected.

A. Stewart, J. Tisdale, C. Dunbar, 1998, Blood.

Patients with myeloid malignancies bearing PDGFRB fusion genes achieve durable long-term remissions with imatinib.

R. Aguiar, N. Cross, P. Rousselot, 2014, Blood.

Intrabone transplantation of CD34+ cells with optimized delivery does not enhance engraftment in a rhesus macaque model.

R. F. Hoyt, P. Choyke, W. Telford, 2020, Blood advances.

Pharmacological Modulation of Humoral Immunity in a Nonhuman Primate Model of AAV Gene Transfer for Hemophilia B

C. Dunbar, R. Donahue, M. Metzger, 2012, Molecular therapy : the journal of the American Society of Gene Therapy.

Retrovirus-mediated transfer and expression of the interleukin-3 gene in mouse hematopoietic cells result in a myeloproliferative disorder

A. Nienhuis, D. Bodine, S. Chung, 1989, Molecular and cellular biology.

CD9 up-regulation on CD34+ cells with ingenol 3,20-dibenzoate does not improve homing in NSG mice.

C. Dunbar, A. Larochelle, F. Racke, 2011, Blood.

aplastic anemia that can be sustained on discontinuation of drug Eltrombopag restores trilineage hematopoiesis in refractory severe

B. Dumitriu, P. Scheinberg, M. Bevans, 2014 .

Pathophysiology and management of thrombocytopenia in bone marrow failure: possible clinical applications of TPO receptor agonists in aplastic anemia and myelodysplastic syndromes

N. Young, C. Dunbar, D. Townsley, 2013, International Journal of Hematology.

Eltrombopag in aplastic anaemia

C. Dunbar, D. Townsley, Young, 2015 .

Lineage Analysis of the FIPL1-PDGFRα Fusion Gene in Myeloproliferative Hypereosinophilic Syndrome.

J. P. McCoy, T. Nutman, C. Dunbar, 2004 .

Tumor-specific recognition of human myeloma cells by idiotype-induced CD8(+) T cells.

S. Jagannath, N. Munshi, L. Kwak, 2000, Blood.

Prediction and prevention of transplant-related mortality from pulmonary causes after total body irradiation and allogeneic stem cell transplantation.

S. Solomon, A. Barrett, R. Childs, 2005, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

Reduced Genotoxicity of Avian Sarcoma Leukosis Virus Vectors in Rhesus Long-term Repopulating Cells Compared to Standard Murine Retrovirus Vectors.

T. Wolfsberg, G. Renaud, S. Hughes, 2008, Molecular therapy : the journal of the American Society of Gene Therapy.

Dexpramipexole As a Steroid-Sparing Agent in Hypereosinophilic Syndromes (HES): An Open-Label Proof-of-Concept Study

A. Signore, C. Dunbar, S. Dworetzky, 2016 .

Large granular lymphocytic proliferation‐associated cyclic thrombocytopenia

M. Stetler-Stevenson, C. Dunbar, P. Fogarty, 2005, American journal of hematology.

High-dose cyclophosphamide in severe aplastic anaemia: a randomised trial

N. Geller, N. Young, A. Barrett, 2000, The Lancet.

Gene therapy approaches for multiple myeloma.

S. Russell, C. Dunbar, 2001, Seminars in hematology.

Cynthia E . Dunbar and Stefan Fruehauf Farastuk Bozorgmehr , Stefanie Laufs , Stephanie E . Sellers , Ingo Roeder , Werner J . Repopulating Cells Transplantation of Multidrug Resistance 1 Retrovirally Transduced Long-Term

C. Dunbar, W. Zeller, 2007 .

CRISPR/Cas9‐mediated introduction of the sodium/iodide symporter gene enables noninvasive in vivo tracking of induced pluripotent stem cell‐derived cardiomyocytes

P. Choyke, X. Zhang, S. Pittaluga, 2020, Stem cells translational medicine.

Retroviral transfer of the glucocerebrosidase gene into CD34+ cells from patients with Gaucher disease: in vivo detection of transduced cells without myeloablation.

R. Schiffmann, S. Karlsson, R. Brady, 1998, Human gene therapy.

CNS interleukin-3 (IL-3) expression and neurological syndrome in antisense-IL-3 transgenic mice.

J. P. Schwartz, H. Young, C. Dunbar, 1999, Journal of neuropathology and experimental neurology.

Intercellular transfer to signaling endosomes regulates an ex vivo bone marrow niche

J. Lippincott-Schwartz, J. Gillette, C. Dunbar, 2009, Nature Cell Biology.

achieve durable long-term remissions with imatinib fusion genes PDGFRB Patients with myeloid malignancies bearing

R. Aguiar, P. Rousselot, C. Dunbar, 2014 .

Gene marking and gene therapy directed at primary hematopoietic cells

N. Young, C. Dunbar, 1996, Current opinion in hematology.

Comparative engraftment and clonality of macaque HSPCs expanded on human umbilical vein endothelial cells versus non-expanded cells

P. Dagur, Chuanfeng Wu, Michael Ginsberg, 2021, Molecular therapy. Methods & clinical development.

Sorting of transgenic secretory proteins in rhesus macaque parotid glands after adenovirus-mediated gene transfer.

B. Baum, C. Dunbar, R. Donahue, 2008, Human gene therapy.

BCL2A1a Over-Expression in Murine Hematopoietic Stem and Progenitor Cells Decreases Apoptosis and Results in Hematopoietic Transformation

R. Calado, C. Dunbar, M. Eckhaus, 2012, PloS one.

Human gene marker/therapy clinical protocols.

R. Haubrich, K. Cornetta, J. Roth, 1999, Human gene therapy.

Analysis of origin and optimization of expansion and transduction of circulating peripheral blood endothelial progenitor cells in the rhesus macaque model.

C. Dunbar, R. Donahue, S. Sellers, 2002, Human gene therapy.

Barcode clonal tracking of tissue-resident immune cells in rhesus macaque highlights distinct clonal distribution pattern of tissue NK cells

Marvin L. Thomas, J. Brenchley, Chuanfeng Wu, 2022, Frontiers in Immunology.

Impact of CMV Infection on Natural Killer Cell Clonal Repertoire in CMV-Naïve Rhesus Macaques

Chuanfeng Wu, C. Dunbar, R. Donahue, 2019, Front. Immunol..

Geographic clonal tracking in macaques provides insights into HSPC migration and differentiation

E. L. Potter, M. Roederer, Chuanfeng Wu, 2018, The Journal of experimental medicine.

Low-dose total body irradiation causes clonal fluctuation of primate hematopoietic stem and progenitor cells.

C. von Kalle, M. Laukkanen, C. Dunbar, 2005, Blood.

Busulfan Combined with Immunosuppression Allows Efficient Engraftment of Gene-Modified Cells in a Rhesus Macaque Model.

J. Tisdale, C. Dunbar, R. Donahue, 2019, Molecular therapy : the journal of the American Society of Gene Therapy.

Human and rhesus macaque hematopoietic stem cells cannot be purified based only on SLAM family markers.

S. Morrison, K. Keyvanfar, S. Anderson, 2011, Blood.

T cell receptor VB repertoire diversity in patients with immune thrombocytopenia following splenectomy

A. Risitano, J. Bussel, C. Dunbar, 2003, Clinical and experimental immunology.

Stem and progenitor cell therapies: insights from non-human primate models.

C. Dunbar, 2004, Cytotherapy.

Pilot study of high dose ICE (ifosfamide, carboplatin, etoposide) chemotherapy and autologous bone marrow transplant (ABMT) with neoR-transduced bone marrow and peripheral blood stem cells in patients with metastatic breast cancer.

W. Wilson, A. Nienhuis, K. Cowan, 1993, Human gene therapy.

Regulated Apoptosis of Genetically Modified Hematopoietic Stem and Progenitor Cells Via an Inducible Caspase‐9 Suicide Gene in Rhesus Macaques

K. Keyvanfar, C. Dunbar, R. Donahue, 2015, Stem cells.

Development of an inducible caspase-9 safety switch for pluripotent stem cell–based therapies

Chuanfeng Wu, C. Dunbar, A. Larochelle, 2014, Molecular therapy. Methods & clinical development.

Direct comparison of RD114-pseudotyped versus amphotropic-pseudotyped retroviral vectors for transduction of rhesus macaque long-term repopulating cells.

C. Dunbar, R. Donahue, B. Agricola, 2003, Molecular therapy : the journal of the American Society of Gene Therapy.

Adaptive NK cells can persist in patients with GATA2 mutation depleted of stem and progenitor cells.

S. Holland, A. Hsu, P. Aukrust, 2017, Blood.

Assessment of rapid remobilization intervals with G–CSF and SCF in murine and rhesus macaque models

C. Dunbar, R. Donahue, M. Metzger, 2001, Transfusion.

IFN‐γ regulates survival and function of tumor‐induced CD11b+Gr‐1high myeloid derived suppressor cells by modulating the anti‐apoptotic molecule Bcl2a1

M. Manns, T. Greten, Chi A. Ma, 2014, European journal of immunology.

In Vivo Tracking of Adoptively Transferred Natural Killer Cells in Rhesus Macaques Using 89Zirconium-Oxine Cell Labeling and PET Imaging

P. Choyke, R. Childs, C. Dunbar, 2020, Clinical Cancer Research.

High-dose cyclophosphamide with autologous lymphocyte-depleted peripheral blood stem cell (PBSC) support for treatment of refractory chronic autoimmune thrombocytopenia.

N. Young, A. Barrett, A. Gratwohl, 2003, Blood.

After Breast Cancer Chemotherapy Engraftment of MDR1 and NeoR Gene-Transduced Hematopoietic Cells

I. Pastan, M. Gottesman, D. Venzon, 2013 .

Paclitaxel chemotherapy after autologous stem-cell transplantation and engraftment of hematopoietic cells transduced with a retrovirus containing the multidrug resistance complementary DNA (MDR1) in metastatic breast cancer patients.

W. Wilson, S. Steinberg, I. Pastan, 1999, Clinical cancer research : an official journal of the American Association for Cancer Research.

No discrepancy between in vivo gene marking efficiency assessed in peripheral blood populations compared with bone marrow progenitors or CD34+ cells.

S. Karlsson, D. Williams, D. Bodine, 1999, Human gene therapy.

Improved Amphotropic Retrovirus‐Mediated Gene Transfer into Hematopoietic Stem Cells

D. Bodine, C. Dunbar, R. Donahue, 1998, Annals of the New York Academy of Sciences.

Gene Transfer to Hematopoietic Cells: Progress and Problems

C. Dunbar, 1998 .

Retroviral gene transduction of adult peripheral blood or marrow-derived CD34+ cells for six hours without growth factors or on autologous stroma does not improve marking efficiency assessed in vivo.

K. Cowan, J. O’Shaughnessy, J. Zujewski, 1997, Blood.

Transduction of hematopoietic stem cells in humans and in nonhuman primates

D. Bodine, T. Soma, J. Zujewski, 1997, Stem cells.

In vivo selective expansion of gene-modified hematopoietic cells in a nonhuman primate model

K. Ozawa, N. Ageyama, K. Terao, 2002, Gene Therapy.

In vivo persistence of retrovirally transduced murine long-term repopulating cells is not limited by expression of foreign gene products in the fully or minimally myeloablated setting.

N. Giri, J. Tisdale, Y. Hanazono, 2001, Human gene therapy.

Prolonged high-level detection of retrovirally marked hematopoietic cells in nonhuman primates after transduction of CD34+ progenitors using clinically feasible methods.

J. Tisdale, C. Dunbar, R. Donahue, 2000, Molecular therapy : the journal of the American Society of Gene Therapy.

Gene Transfer into Hematopoietic Cells: Implications for Cancer Therapy

A. Nienhuis, D. Bodine, K. Cowan, 1994, Annals of the New York Academy of Sciences.

Rapid mobilization of hematopoietic progenitors by AMD3100 and catecholamines is mediated by CXCR4-dependent SDF-1 release from bone marrow stromal cells

E. Buss, P. Frenette, M. Tesio, 2011, Leukemia.

Positive selection of CD34+ hematopoietic cells using an immunoaffinity column results in T cell-depletion equivalent to elutriation.

J. O’Shaughnessy, C. Dunbar, M. Cottler-Fox, 1995, Experimental hematology.

Human gene marker/therapy clinical protocols.

K. Cornetta, J. Roth, R. Crystal, 1996, Human gene therapy.

Differences in the Phenotype, Cytokine Gene Expression Profiles, and In Vivo Alloreactivity of T Cells Mobilized with Plerixafor Compared with G-CSF

J. P. McCoy, N. Geller, J. Joo, 2013, Journal of Immunology.

Plerixafor Compared with G-CSF Alloreactivity of T Cells Mobilized with Expression Profiles, and In Vivo Differences in the Phenotype, Cytokine Gene

J. P. McCoy, C. Dunbar, Susan Wong, 2013 .

Investigation of the impact of clonal hematopoiesis on severity and pathophysiology of COVID-19 in rhesus macaques

D. Douek, Mark G. Lewis, M. Roederer, 2023, bioRxiv.

Gene therapy comes of age

Michel Sadelain, J Keith Joung, Donald B Kohn, 2018, Science.

Distinct Genomic Integration of MLV and SIV Vectors in Primate Hematopoietic Stem and Progenitor Cells

Christof von Kalle, Manfred Schmidt, Peiman Hematti, 2004, PLoS biology.

The MDS1-EVI1 gene complex as a retrovirus integration site: impact on behavior of hematopoietic cells and implications for gene therapy.

C. Dunbar, Cynthia E Dunbar, Jean-Yves Métais, 2008, Molecular therapy : the journal of the American Society of Gene Therapy.

Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1

Yang Du, Manuel Grez, Hanno Glimm, 2006, Nature Medicine.

Efficient Characterization of Retro‐, Lenti‐, and Foamyvector‐Transduced Cell Populations by High‐Accuracy Insertion Site Sequencing

S. Karlsson, H. Glimm, M. Wissler, 2003, Annals of the New York Academy of Sciences.

Efficient gene transfer into rhesus repopulating hematopoietic stem cells using a simian immunodeficiency virus-based lentiviral vector system.

K. Keyvanfar, A. Nienhuis, J. Gray, 2004, Blood.

The impact of low-dose busulfan on clonal dynamics in nonhuman primates.

C. von Kalle, M. Laukkanen, C. Dunbar, 2004, Blood.

Ongoing Production of Tissue-Resident Macrophages from Hematopoietic Stem Cells in Healthy Adult Macaques

J. Brenchley, Chuanfeng Wu, C. Dunbar, 2022, bioRxiv.

Bone marrow homing and engraftment of human hematopoietic stem and progenitor cells is mediated by a polarized membrane domain.

J. Lippincott-Schwartz, A. Barrett, J. Gillette, 2012, Blood.

Telomere dynamics and hematopoietic differentiation of human DKC1-mutant induced pluripotent stem cells.

F. Donaires, R. Calado, C. Dunbar, 2019, Stem cell research.

Defective telomere elongation and hematopoiesis from telomerase-mutant aplastic anemia iPSCs.

T. Ried, N. Young, Chuanfeng Wu, 2013, The Journal of clinical investigation.

Barcoding of Macaque Hematopoietic Stem and Progenitor Cells: A Robust Platform to Assess Vector Genotoxicity

Chuanfeng Wu, C. Dunbar, R. Donahue, 2018, Molecular therapy. Methods & clinical development.

No impact of lentiviral transduction on hematopoietic stem/progenitor cell telomere length or gene expression in the rhesus macaque model.

B. Dumitriu, N. Young, R. Calado, 2014, Molecular therapy : the journal of the American Society of Gene Therapy.

Integration-specific In Vitro Evaluation of Lentivirally Transduced Rhesus CD34+ Cells Correlates With In Vivo Vector Copy Number

J. Tisdale, C. Dunbar, R. Donahue, 2013, Molecular therapy. Nucleic acids.

Assessing the risks of genotoxicity in the therapeutic development of induced pluripotent stem cells.

C. Dunbar, T. Winkler, S. Hong, 2013, Molecular therapy : the journal of the American Society of Gene Therapy.

Integration-specific In Vitro Evaluation of Lentivirally Transduced Rhesus CD34+ Cells Correlates With In Vivo Vector Copy Number.

J. Tisdale, C. Dunbar, R. Donahue, 2013, Molecular therapy. Nucleic acids.

Challenges in vector and trial design using retroviral vectors for long-term gene correction in hematopoietic stem cell gene therapy.

Hung Fan, Alessandro Aiuti, Jacqueline Corrigan-Curay, 2012, Molecular therapy : the journal of the American Society of Gene Therapy.

Hematopoietic stem cell engineering at a crossroads.

Michel Sadelain, Isabelle Rivière, M. Sadelain, 2012, Blood.

Stem cell gene therapy: the risks of insertional mutagenesis and approaches to minimize genotoxicity

Chuanfeng Wu, C. Dunbar, 2011, Frontiers of medicine.

Feline Leukemia Virus Integrase And Capsid Packaging Functions Do Not Change The Insertion Profile Of Standard Moloney Retroviral Vectors

T. Wolfsberg, J. Abkowitz, A. Nguyen, 2010, Gene Therapy.

Sustained high-level polyclonal hematopoietic marking and transgene expression 4 years after autologous transplantation of rhesus macaques with SIV lentiviral vector-transduced CD34+ cells.

Jean A. Roayaei, T. Wolfsberg, G. Renaud, 2009, Blood.

No Evidence of Clonal Dominance in Primates up to 4 Years Following Transplantation of Multidrug Resistance 1 Retrovirally Transduced Long‐Term Repopulating Cells

W. Zeller, I. Roeder, C. Dunbar, 2007, Stem cells.

Cytokine-independent growth and clonal expansion of a primary human CD8+ T-cell clone following retroviral transduction with the IL-15 gene.

K. Cornetta, T. Ried, S. Rosenberg, 2007, Blood.

The yin and yang of stem cell gene therapy: insights into hematopoiesis, leukemogenesis, and gene therapy safety.

C. Dunbar, 2007, Hematology. American Society of Hematology. Education Program.

Recurrent Retroviral Vector Integration at the MDS1-EVI1 Locus in Rhesus Long-Term Repopulating Hematopoietic Stem Cells.

M. Laukkanen, C. Dunbar, R. Donahue, 2004 .

Polyclonal long-term repopulating stem cell clones in a primate model.

C. von Kalle, M. Wissler, J. Tisdale, 2002, Blood.

Acquired somatic mutations in PNH reveal long-term maintenance of adaptive NK cells independent of HSPCs.

N. Young, Chuanfeng Wu, C. Dunbar, 2017, Blood.

Genetic Inactivation of CD33 in Hematopoietic Stem Cells to Enable CAR T Cell Immunotherapy for Acute Myeloid Leukemia

Adam Bagg, Cynthia E. Dunbar, Maksim Shestov, 2018, Cell.

Helper virus induced T cell lymphoma in nonhuman primates after retroviral mediated gene transfer

M. Raffeld, K. Zsebo, A. Nienhuis, 1992, The Journal of experimental medicine.

5‐AZACYTIDINE TREATMENT IN A βo‐THALASSAEMIC PATIENT UNABLE TO BE TRANSFUSED DUE TO MULTIPLE ALLOANTIBODIES

Y. Kan, A. Nienhuis, C. Dunbar, 1989, British journal of haematology.

Improved retroviral gene transfer into murine and Rhesus peripheral blood or bone marrow repopulating cells primed in vivo with stem cell factor and granulocyte colony-stimulating factor.

D. Bodine, C. Dunbar, R. Donahue, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Eltrombopag Added to Standard Immunosuppression for Aplastic Anemia

B. Dumitriu, Xingmin Feng, M. Desierto, 2017, The New England journal of medicine.

Eltrombopag and improved hematopoiesis in refractory aplastic anemia.

B. Dumitriu, Xingmin Feng, N. Young, 2012, The New England journal of medicine.

Clonal tracking of erythropoiesis in rhesus macaques

Chuanfeng Wu, C. Dunbar, R. Donahue, 2019, Haematologica.

An Introduction to the Analysis of Single-Cell RNA-Sequencing Data

Mark Danielsen, Aisha A. AlJanahi, Cynthia E. Dunbar, 2018, Molecular therapy. Methods & clinical development.

Interrogation of clonal tracking data using barcodetrackR

Chuanfeng Wu, C. Dunbar, Ryland D. Mortlock, 2021, Nature Computational Science.

barcodetrackR: an R package for the interrogation of clonal tracking data

Chuanfeng Wu, C. Dunbar, Ryland D. Mortlock, 2020, bioRxiv.

Imatinib inhibits T-cell receptor-mediated T-cell proliferation and activation in a dose-dependent manner.

D. Douek, M. K. Magnússon, A. Wiestner, 2005, Blood.

Rhesus iPSC Safe Harbor Gene-Editing Platform for Stable Expression of Transgenes in Differentiated Cells of All Germ Layers.

S. Pittaluga, T. Liang, I. Tunc, 2017, Molecular therapy : the journal of the American Society of Gene Therapy.

An AAVS1-targeted minigene platform for correction of iPSCs from all five types of chronic granulomatous disease.

S. Holland, D. Kuhns, C. Dunbar, 2015, Molecular therapy : the journal of the American Society of Gene Therapy.

Efficient differentiation of cardiomyocytes and generation of calcium-sensor reporter lines from nonhuman primate iPSCs

Chengyu Liu, C. Dunbar, H. San, 2018, Scientific Reports.

Modeling Human Bone Marrow Failure Syndromes Using Pluripotent Stem Cells and Genome Engineering.

C. Dunbar, T. Winkler, M. Jung, 2015, Molecular therapy : the journal of the American Society of Gene Therapy.

Gene Editing of Human Hematopoietic Stem and Progenitor Cells: Promise and Potential Hurdles.

C. Dunbar, K. Yu, Hannah Natanson, 2016, Human gene therapy.

Rhesus Macaque iPSC Generation and Maintenance.

C. Dunbar, Yongshun Lin, T. Winkler, 2017, Current protocols in stem cell biology.

Dynamic clonal analysis of murine hematopoietic stem and progenitor cells marked by 5 fluorescent proteins using confocal and multiphoton microscopy.

D. Malide, C. Dunbar, J. Métais, 2012, Blood.

Sox4 cooperates with PU.1 haploinsufficiency in murine myeloid leukemia.

N. Jenkins, C. Dunbar, N. Copeland, 2011, Blood.

Hematopoietic stem-cell behavior in nonhuman primates.

Peter Guttorp, Bryan E Shepherd, Hans-Peter Kiem, 2007, Blood.

Transduction of rhesus macaque hematopoietic stem and progenitor cells with avian sarcoma and leukosis virus vectors.

S. Hughes, C. Dunbar, R. Donahue, 2007, Human gene therapy.

Retroviral transduction efficiency of G-CSF+SCF-mobilized peripheral blood CD34+ cells is superior to G-CSF or G-CSF+Flt3-L-mobilized cells in nonhuman primates.

C. Dunbar, R. Donahue, S. Sellers, 2003, Blood.

Update on the use of nonhuman primate models for preclinical testing of gene therapy approaches targeting hematopoietic cells.

C. Dunbar, R. Donahue, Robert E. Donahue, 2001, Human gene therapy.

Multilineage involvement of the fusion gene in patients with FIP1L1/PDGFRA‐positive hypereosinophilic syndrome

T. Nutman, C. Dunbar, S. Pack, 2006, British journal of haematology.

Highly efficient endosomal labeling of progenitor and stem cells with large magnetic particles allows magnetic resonance imaging of single cells.

Alan P Koretsky, Erik M Shapiro, A. Koretsky, 2003, Blood.

Retroviral mediated gene transfer of the Fanconi anemia complementation group C gene to hematopoietic progenitors of group C patients.

N. Young, A. Barrett, C. Dunbar, 1997, Human gene therapy.

Avoidance of stimulation improves engraftment of cultured and retrovirally transduced hematopoietic cells in primates.

C. Dunbar, R. Donahue, I. Kato, 2001, The Journal of clinical investigation.

Differential diagnosis of bone marrow failure syndromes guided by machine learning.

Christopher M. Siwy, Ronald M. Summers, Paul Liu, 2022, Blood.

Retroviral transduction and engraftment ability of primate hematopoietic progenitor and stem cells transduced under serum-free versus serum-containing conditions.

C. Dunbar, R. Donahue, S. Sellers, 2002, Molecular therapy : the journal of the American Society of Gene Therapy.

Mobilization as a preparative regimen for hematopoietic stem cell transplantation.

J. Abkowitz, C. Dunbar, A. Larochelle, 2004, Blood.

Understanding and Overcoming Adverse Consequences of Genome Editing on Hematopoietic Stem and Progenitor Cells.

C. Dunbar, Byung-Chul Lee, Richard J. Lozano, 2021, Molecular therapy : the journal of the American Society of Gene Therapy.

Primary T lymphocytes as targets for gene therapy.

Y. Hanazono, C. Dunbar, K. Brown, 2000, Journal of hematotherapy & stem cell research.

iPSCs and fibroblast subclones from the same fibroblast population contain comparable levels of sequence variations

Brian W Davis, James C Mullikin, Nancy F Hansen, 2017, Proceedings of the National Academy of Sciences.

53 – Hematopoietic Stem Cell Mobilization and Homing

C. Dunbar, D. Orlic, R. Seggewiss, 2004 .

Absence of donor-derived keratinocyte stem cells in skin tissues cultured from patients after mobilized peripheral blood hematopoietic stem cell transplantation.

R. Childs, C. Dunbar, E. Sloand, 2002, Experimental hematology.

Molecular characterisation of side population cells with cancer stem cell-like characteristics in small-cell lung cancer

C. D. Salcido, L. Varticovski, C. Dunbar, 2010, British Journal of Cancer.

Eltrombopag restores trilineage hematopoiesis in refractory severe aplastic anemia that can be sustained on discontinuation of drug.

B. Dumitriu, N. Young, M. Bevans, 2014, Blood.

The Role of Nonhuman Primate Animal Models in the Clinical Development of Pluripotent Stem Cell Therapies.

C. Dunbar, Yongshun Lin, J. Zou, 2016, Molecular therapy : the journal of the American Society of Gene Therapy.

Comparison of busulfan and total body irradiation conditioning on hematopoietic clonal dynamics following lentiviral gene transfer in rhesus macaques

Chuanfeng Wu, J. Tisdale, C. Dunbar, 2022, Molecular therapy. Methods & clinical development.

Many multipotential gene-marked progenitor or stem cell clones contribute to hematopoiesis in nonhuman primates.

J. Tisdale, C. Dunbar, R. Donahue, 2000, Blood.

CD34+ cell dose predicts survival, posttransplant morbidity, and rate of hematologic recovery after allogeneic marrow transplants for hematologic malignancies.

C. Dunbar, D. Couriel, J. Barrett, 1996, Blood.

Measurement of the absolute immature platelet number reflects marrow production and is not impacted by platelet transfusion

K. Calvo, C. Dunbar, S. Leitman, 2012, Transfusion.

Persistent elevation of plasma thrombopoietin levels after treatment in severe aplastic anemia.

B. Dumitriu, Xingmin Feng, N. Young, 2017, Experimental hematology.

Eltrombopag maintains human hematopoietic stem and progenitor cells under inflammatory conditions mediated by IFN-γ.

Heather D. Huntsman, Xingmin Feng, N. Young, 2019, Blood.

CD34+ cell dose predicts survival, posttransplant morbidity, and rate of hematologic recovery after allogeneic marrow transplants for hematologic malignancies

C. Dunbar, D. Couriel, E. Read, 1996 .

Update on hematopoietic stem cell gene transfer using non-human primate models.

C. Dunbar, Jiong Hu, 2002, Current opinion in molecular therapeutics.

Interferon-γ Perturbs Key Signaling Pathways Induced By Thrombopoietin, but Not Eltrombopag, in Human Hematopoietic Stem/Progenitor Cells

N. Young, C. Dunbar, A. Larochelle, 2016 .

In Vitro Culture During Retroviral Transduction Improves Thymic Repopulation and Output After Total Body Irradiation and Autologous Peripheral Blood Progenitor Cell Transplantation in Rhesus Macaques

S. Pittaluga, R. Koup, D. Douek, 2006, Stem cells.

Transcriptome analysis reveals similarities between human blood CD3− CD56bright cells and mouse CD127+ innate lymphoid cells

J. Strominger, C. Dunbar, A. Cerdeira, 2017, Scientific Reports.

Expanded NK cells used for adoptive cell therapy maintain diverse clonality and contain long-lived memory-like NK cell populations

K. Rezvani, Chuanfeng Wu, C. Dunbar, 2022, Molecular therapy oncolytics.

Validation and Long-Term Follow Up of CD33 Off-Targets Predicted In Vitro and In Silico Using Error-Corrected Sequencing in Rhesus Macaques

S. Tsai, T. Cathomen, I. Tunc, 2020, bioRxiv.

Eltrombopag for patients with moderate aplastic anemia or uni-lineage cytopenias.

B. Dumitriu, N. Young, M. Albitar, 2020, Blood advances.

Genotoxic Lemons Become Epigenomic Lemonade.

C. Dunbar, Stefan Cordes, 2018, Cell stem cell.

Human hematopoietic stem cells from mobilized peripheral blood can be purified based on CD49f integrin expression.

Heather D. Huntsman, K. Keyvanfar, R. Childs, 2015, Blood.

Clonal tracking of haematopoietic cells: insights and clinical implications

Chuanfeng Wu, C. Dunbar, Stefan Cordes, 2020, British journal of haematology.

CRISPR/Cas9 PIG -A gene editing in nonhuman primate model demonstrates no intrinsic clonal expansion of PNH HSPCs.

C. Dunbar, R. Donahue, Yifan Zhou, 2019, Blood.

Aberrant Clonal Hematopoiesis following Lentiviral Vector Transduction of HSPCs in a Rhesus Macaque.

Chuanfeng Wu, J. Tisdale, K. Calvo, 2019, Molecular therapy : the journal of the American Society of Gene Therapy.

An All Antibody Approach for Conditioning Bone Marrow for Hematopoietic Stem Cell Transplantation with Anti-cKIT and Anti-CD47 in Non-Human Primates

I. Weissman, C. Takimoto, R. Majeti, 2019, Blood.

George Stamatoyannopoulos (1934–2018)

A. Nienhuis, D. Bodine, C. Dunbar, 2018, Molecular Therapy.

Blood and the American Society of Hematology in 2008: looking back and moving forward

C. Dunbar, 2008 .

Quantitative stability of hematopoietic stem and progenitor cell clonal output in rhesus macaques receiving transplants.

Chuanfeng Wu, C. Dunbar, R. Donahue, 2017, Blood.

GATA2 deficiency and human hematopoietic development modeled using induced pluripotent stem cells.

S. Holland, S. Hassan, F. Donaires, 2018, Blood advances.

Clonal tracking of rhesus macaque hematopoiesis highlights a distinct lineage origin for natural killer cells.

Chuanfeng Wu, C. Dunbar, R. Donahue, 2014, Cell stem cell.

A new spontaneous mouse mutation in the Kcne1 gene

W. Frankel, C. Dunbar, V. Letts, 2000, Mammalian Genome.

Serial Cardiac Magnetic Resonance Imaging of Injected Mesenchymal Stem Cells

Elliot R. McVeigh, Robert J. Lederman, Michael A. Guttman, 2003, Circulation.

Blood's 70th anniversary: CARs on the Blood highway.

C. Dunbar, 2016, Blood.

Acute myeloid leukemia is associated with retroviral gene transfer to hematopoietic progenitor cells in a rhesus macaque.

C. von Kalle, S. Pittaluga, W. Young, 2006, Blood.

Tissue Trafficking Kinetics of Rhesus Macaque Natural Killer Cells Measured by Serial Intravascular Staining

E. L. Potter, M. Roederer, Chuanfeng Wu, 2022, Frontiers in Immunology.

Transgenic mice expressing antisense interleukin-3 RNA develop a B-cell lymphoproliferative syndrome or neurologic dysfunction.

D. Cockayne, A. Nienhuis, D. Bodine, 1994, Blood.

Antithymocyte Globulin for Treatment of the Bone Marrow Failure Associated with Myelodysplastic Syndromes

N. Young, A. Barrett, Y. Saunthararajah, 2002, Annals of Internal Medicine.

Eltrombopag mobilizes iron in patients with aplastic anemia.

L. Sokoll, N. Young, C. Dunbar, 2018, Blood.

Functional Niche Competition Between Normal Hematopoietic Stem and Progenitor Cells and Myeloid Leukemia Cells

Elisabeth F. Heuston, Xingmin Feng, Jichun Chen, 2015, Stem cells.

Dexpramipexole as an oral steroid-sparing agent in hypereosinophilic syndromes.

M. Fay, C. Dunbar, S. Dworetzky, 2018, Blood.

Amendment to clinical research projects. Genetic marking with retroviral vectors to study the feasibility of stem cell gene transfer and the biology of hematopoietic reconstitution after autologous transplantation in multiple myeloma, chronic myelogenous leukemia, or metastatic breast cancer.

A. Nienhuis, P. Quesenberry, K. Cowan, 1993, Human gene therapy.

A Pilot Study Of Rituximab In Patients With Moderate Aplastic Anemia, Diamond-Blackfan Anemia and Pure Red Cell Aplasia

N. Young, P. Scheinberg, A. Wiestner, 2013 .

Macaque Clonal Hematopoiesis Model Demonstrates Expansion of TET2-Disrupted Clones and Utility for Testing Interventions.

G. Vassiliou, L. Busque, J. Mattison, 2022, Blood.

Effect of chronic cytokine therapy on clonal dynamics in nonhuman primates.

C. von Kalle, D. Follmann, C. Dunbar, 2004, Blood.

Stem Cell Gene Transfer: Insights into Integration and Hematopoiesis from Primate Genetic Marking Studies

C. Dunbar, 2005, Annals of the New York Academy of Sciences.

The Impact of ex Vivo Cytokine Stimulation on Engraftment of Primitive Hematopoietic Cells in a Non‐Human Primate Model

C. Dunbar, R. Donahue, M. Takatoku, 2001, Annals of the New York Academy of Sciences.

Bone Marrow as a Source of Cells for Paroxysmal Nocturnal Hemoglobinuria Detection

N. Young, R. Braylan, K. Calvo, 2018, American journal of clinical pathology.

Antibody-mediated cell labeling of peripheral T cells with micron-sized iron oxide particles (MPIOs) allows single cell detection by MRI.

Alan P Koretsky, Erik M Shapiro, A. Koretsky, 2007, Contrast media & molecular imaging.

Clonal expansion and compartmentalized maintenance of rhesus macaque NK cell subsets

Chuanfeng Wu, R. Childs, C. Dunbar, 2018, Science immunology.

564. The Cytotoxic Effect of RNA-Guided Endonuclease Cas9 on Human Hematopoietic Stem and Progenitor Cells (HSPCs)

C. Dunbar, K. Yu, M. Corat, 2016 .

Prediction and Validation of Hematopoietic Stem and Progenitor Cell Off-Target Editing in Transplanted Rhesus Macaques.

S. Tsai, T. Cathomen, I. Tunc, 2021, Molecular therapy : the journal of the American Society of Gene Therapy.

A Novel Method to Study the in Vivo Trafficking and Homing of Adoptively Transferred NK Cells in Rhesus Macaques and Humans

Marvin L. Thomas, R. F. Hoyt, P. Choyke, 2014 .

Macaque CRISPR/Cas9 Age-Related Clonal Hematopoiesis Model Demonstrates Expansion of TET2-Mutated Clones and Applicability for Testing Mitigation Approaches

C. Dunbar, R. Donahue, Yifan Zhou, 2020 .

Immunosuppression and growth factors for severe aplastic anemia: new data for old questions

C. Dunbar, David J. Young, 2020, Haematologica.

In vivo clonal tracking of hematopoietic stem and progenitor cells marked by five fluorescent proteins using confocal and multiphoton microscopy.

D. Malide, C. Dunbar, J. Métais, 2014, Journal of visualized experiments : JoVE.

The presence of the carboxy-terminal fragment of fibronectin allows maintenance of non-human primate long-term hematopoietic repopulating cells during extended ex vivo culture and transduction.

J. Tisdale, C. Dunbar, R. Donahue, 2004, Experimental hematology.

Transcriptome analysis reveals similarities between human blood CD3− CD56bright cells and mouse CD127+ innate lymphoid cells

J. Strominger, R. Childs, C. Dunbar, 2017, Scientific Reports.

Special report Collection of hematopoietic stem cells from patients with autoimmune diseases

J. Snowden, P. Mcsweeney, C. Dunbar, 2001 .

Studies in a mosaic DBA patient and chimeric mice reveal erythroid cell-extrinsic contributions to erythropoiesis.

J. Abkowitz, R. Doty, S. Chandrasekharappa, 2022, Blood.

NADPH oxidase correction by mRNA transfection of apheresis granulocytes in chronic granulomatous disease.

Linhong Li, D. Kuhns, D. Stroncek, 2020, Blood advances.

Collection of hematopoietic stem cells from patients with autoimmune diseases

J. Snowden, P. Mcsweeney, R. Nash, 2001, Bone Marrow Transplantation.

Response: More on ghostbusting

M. Tallman, C. Dunbar, 2009 .

'Ghostbusting' at blood.

M. Tallman, C. Dunbar, 2009, Blood.

Evaluation of a rapamycin-regulated serotype 2 adeno-associated viral vector in macaque parotid glands.

T. Clackson, V. Rivera, C. Dunbar, 2010, Oral diseases.

Statistical inference for partially observed branching processes with application to cell lineage tracking of in vivo hematopoiesis

Peter Guttorp, Jason Xu, Vladimir N. Minin, 2016, The Annals of Applied Statistics.

Statistical inference in partially observed stochastic compartmental models with application to cell lineage tracking of in vivo hematopoiesis

Peter Guttorp, Jason Xu, Vladimir N. Minin, 2016 .

Early reactivation of cytomegalovirus and high risk of interstitial pneumonitis following T-depleted BMT for adults with hematological malignancies.

A. Barrett, C. Dunbar, C. Dunbar, 1996, Bone marrow transplantation.

COOH-terminal-modified interleukin-3 is retained intracellularly and stimulates autocrine growth.

A. Nienhuis, J. Abrams, C. Dunbar, 1989, Science.

Tissue-Resident Clonal Expansions of Rhesus Macaque NK Cells

J. Brenchley, Chuanfeng Wu, C. Dunbar, 2021, Blood.

hematopoietic progenitor cells in a rhesus macaque Acute myeloid leukemia is associated with retroviral gene transfer to

Young, S. Pittaluga, B. Ryu, 2014 .

A pilot study of nonmyeloablative allogeneic hematopoietic stem cell transplant for advanced systemic mastocytosis

A. Barrett, D. Metcalfe, R. Childs, 2006, Bone Marrow Transplantation.

High incidence of adeno- and polyomavirus-induced hemorrhagic cystitis in bone marrow allotransplantation for hematological malignancy following T cell depletion and cyclosporine

S. Rosenfeld, A. Barrett, R. Childs, 1998, Bone Marrow Transplantation.

Abrogation of TGF-β activity during retroviral transduction improves murine hematopoietic progenitor and repopulating cell gene transfer efficiency

T. Soma, Y. Hanazono, C. Dunbar, 1998, Gene Therapy.

Arginine metabolism regulates human erythroid differentiation through hypusination of eIF5A.

M. Sitbon, N. Taylor, L. D. Da Costa, 2023, Blood.

CRISPR/Cas9-Based Safe-Harbor Gene Editing in Rhesus iPSCs.

I. Tunc, C. Dunbar, J. Zou, 2017, Current protocols in stem cell biology.

Anti-interleukin-2 receptor antibody (daclizumab) treatment of corticosteroid-refractory autoimmune thrombocytopenic purpura.

C. Dunbar, M. Rick, P. Fogarty, 2006, Haematologica.

Introduction to clinical applications of stem cells at the National Institutes of Health: a meeting held on 24 May 2004 at the Clinical Center of the National Institutes of Health, Bethesda, Maryland, USA

Cynthia E. Dunbar, R. McKay, E. Nabel, 2004 .

Acute myeloid leukemia is associated with retroviral gene transfer to hematopoietic progenitor cells in a rhesus macaque.

C. von Kalle, S. Pittaluga, A. Nienhuis, 2006, Blood.

Aberrant Clonal Hematopoiesis Following Lentiviral Transduction of HSPC in a Rhesus Macaque

Chuanfeng Wu, J. Tisdale, K. Calvo, 2019, bioRxiv.

Gene therapy comes of age

J. Joung, M. Sadelain, K. Ozawa, 2018, Science.

A plethora of gene therapies for hemoglobinopathies

C. Dunbar, 2021, Nature Medicine.

Treatment optimization and genomic outcomes in refractory severe aplastic anemia treated with eltrombopag.

M. Desierto, N. Young, P. Scheinberg, 2019, Blood.