M. Urabe

发表

Basic Studies Toward Hematopoietic Stem Cell Gene Therapy

K. Ozawa, K. Terao, Y. Hanazono, 2000 .

Long-term tracking of murine hematopoietic cells transduced with a bicistronic retrovirus containing CD24 and EGFP genes

K. Ozawa, Y. Ueda, M. Urabe, 2000, Gene Therapy.

A novel dicistronic AAV vector using a short IRES segment derived from hepatitis C virus genome.

A. Nomoto, K. Ozawa, M. Urabe, 1997, Gene.

Development of a novel selective amplifier gene for controllable expansion of transduced hematopoietic cells.

H. Mano, K. Ozawa, T. Kitamura, 1997, Blood.

Interleukin-10 expression induced by adeno-associated virus vector suppresses proteinuria in Zucker obese rats

H. Mizukami, K. Ozawa, M. Urabe, 2012, Gene Therapy.

Recombinant adeno-associated virus vector-transduced vascular endothelial cells express the thrombomodulin transgene under the regulation of enhanced plasminogen activator inhibitor-1 promoter

S. Madoiwa, J. Mimuro, Y. Sakata, 2001, Gene Therapy.

Adenoassociated Virus–Mediated Prostacyclin Synthase Expression Prevents Pulmonary Arterial Hypertension in Rats

U. Ikeda, K. Shimada, J. Mimuro, 2007, Hypertension.

Survivin overexpression via adeno‐associated virus vector Rh10 ameliorates ischemic damage after middle cerebral artery occlusion in rats

K. Kawai, H. Mizukami, M. Urabe, 2018, The European journal of neuroscience.

IL-21 is not necessary for anti-lymphoma effects of T cells expressing second-generation CD19-specific chimeric antigen receptors in a xenograft mouse model.

H. Mizukami, K. Ozawa, Masataka Nakamura, 2013 .

Overexpression of PTEN increases sensitivity to SN-38, an active metabolite of the topoisomerase I inhibitor irinotecan, in ovarian cancer cells.

Y. Saga, Mitsuaki Suzuki, H. Mizukami, 2002, Clinical cancer research : an official journal of the American Association for Cancer Research.

Gene Therapy for Diabetic Retinopathy in Animal Models and Humans

H. Mizukami, K. Ozawa, M. Urabe, 2011 .

Comprehensive Metabolomic Analysis of IDH1R132H Clinical Glioma Samples Reveals Suppression of β-oxidation Due to Carnitine Deficiency

K. Kawai, E. Sakashita, H. Endo, 2019, Scientific Reports.

Gene therapy prevents disruption of dystrophin-related proteins in a model of hereditary dilated cardiomyopathy in hamsters.

K. Ozawa, M. Urabe, T. Kawada, 2002, Heart, lung & circulation.

Rescue of hereditary form of dilated cardiomyopathy by rAAV-mediated somatic gene therapy: Amelioration of morphological findings, sarcolemmal permeability, cardiac performances, and the prognosis of TO-2 hamsters

Hiroshi Sato, T. Masaki, K. Ozawa, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Morphological and physiological restorations of hereditary form of dilated cardiomyopathy by somatic gene therapy.

K. Ozawa, Y. Nakatsuru, M. Urabe, 2001, Biochemical and biophysical research communications.

AAV6-Mediated IL-10 Expression in the Lung Ameliorates Bleomycin-Induced Pulmonary Fibrosis in Mice.

Y. Saga, H. Mizukami, M. Urabe, 2018, Human gene therapy.

Reciprocal upregulation of Notch signaling molecules in hematopoietic progenitor and mesenchymal stromal cells

H. Mizukami, K. Ozawa, T. Nagai, 2011, Journal of stem cells & regenerative medicine.

Novel anti-tumor mechanism of galanin receptor type 2 in head and neck squamous cell carcinoma cells

T. Carey, H. Mizukami, K. Ozawa, 2013, Cancer science.

Suppression of lymph node and lung metastases of endometrial cancer by muscle‐mediated expression of soluble vascular endothelial growth factor receptor‐3

Y. Saga, Mitsuaki Suzuki, H. Mizukami, 2013, Cancer science.

AAV-mediated VEGF gene transfer into skeletal muscle stimulates angiogenesis and improves blood flow in a rat hindlimb ischemia model.

U. Ikeda, K. Shimada, M. Shibuya, 2002, Cardiovascular research.

Development of a modified selective amplifier gene for hematopoietic stem cell gene therapy

K. Matsuda, K. Ozawa, Y. Ueda, 1999, Gene Therapy.

Adipose tissue as a novel target for in vivo gene transfer by adeno-associated viral vectors.

J. Mimuro, Y. Sakata, H. Mizukami, 2006, Human gene therapy.

Behavioral recovery in 6-hydroxydopamine-lesioned rats by cotransduction of striatum with tyrosine hydroxylase and aromatic L-amino acid decarboxylase genes using two separate adeno-associated virus vectors.

K. Ozawa, M. Urabe, H. Ichinose, 1998, Human gene therapy.

Adeno-associated virus vectors for gene transfer to the brain.

W. Lijun, H. Mizukami, K. Ozawa, 2002, Methods.

Gene therapy of Parkinson's disease using adeno-associated virus (AAV) vectors.

K. Ozawa, M. Urabe, A. Kume, 2000, Journal of neural transmission. Supplementum.

Prevention of dopaminergic neuron death by adeno-associated virus vector-mediated GDNF gene transfer in rat mesencephalic cells in vitro

K. Ozawa, K. Kiuchi, M. Urabe, 1998, Neuroscience Letters.

Adeno‐associated virus vector‐mediated systemic interleukin‐10 expression ameliorates hypertensive organ damage in Dahl salt‐sensitive rats

U. Ikeda, K. Shimada, H. Mizukami, 2008, The journal of gene medicine.

Enhanced Expression of Thymidylate Synthase Mediates Resistance of Uterine Cervical Cancer Cells to Radiation

Y. Saga, M. Fukushima, Mitsuaki Suzuki, 2002, Oncology.

Charged-to-Alanine Scanning Mutagenesis of the N-Terminal Half of Adeno-Associated Virus Type 2 Rep78 Protein

K. Ozawa, M. Urabe, K. Tobita, 1999, Journal of Virology.

Interleukin-10 Expression Mediated by an Adeno-Associated Virus Vector Prevents Monocrotaline-Induced Pulmonary Arterial Hypertension in Rats

U. Ikeda, K. Shimada, H. Mizukami, 2007, Circulation research.

Triple transduction with adeno-associated virus vectors expressing tyrosine hydroxylase, aromatic-L-amino-acid decarboxylase, and GTP cyclohydrolase I for gene therapy of Parkinson's disease.

H. Mizukami, K. Ozawa, M. Urabe, 2000, Human gene therapy.

Gene Transfer into Rat Renal Cells Using Adeno-Associated Virus Vectors

U. Ikeda, K. Shimada, T. Takizawa, 2000, American Journal of Nephrology.

Adeno-associated virus-mediated vascular endothelial growth factor gene transfer into cardiac myocytes.

U. Ikeda, K. Shimada, M. Shibuya, 2000, Journal of cardiovascular pharmacology.

Highly regulated expression of adeno-associated virus large Rep proteins in stable 293 cell lines using the Cre/loxP switching system.

H. Mizukami, K. Ozawa, M. Urabe, 1999, The Journal of general virology.

ADENO-ASSOCIATED VIRUS (AAV) VECTOR MEDIATED TRANSGENE EXPRESSION IN CELL LINE DERIVED FROM MAXILLARY CANCER

K. Ozawa, M. Urabe, A. Kume, 1999 .

Efficient Production of Adeno‐associated Virus Vectors Using Split‐type Helper Plasmids

K. Ozawa, M. Urabe, A. Kume, 1999, Japanese journal of cancer research : Gann.

The Use of Heterologous Promoters for Adeno‐Associated Virus (AAV) Protein Expression in AAV Vector Production

K. Ozawa, M. Urabe, Y. Ogasawara, 1998, Microbiology and immunology.

[Adeno-associated virus vectors and gene therapy].

K. Ozawa, M. Urabe, Keiya Ozawa, 1997, Uirusu.

Gene transfer into vascular cells using adeno-associated virus (AAV) vectors.

U. Ikeda, K. Shimada, T. Takizawa, 1997, Cardiovascular research.

A switching system regulating subcellular localization of nuclear proteins using a viral protease.

K. Ozawa, M. Urabe, A. Kume, 1999, Biochemical and biophysical research communications.

Attenuation of methylglyoxal-induced peritoneal fibrosis: immunomodulation by interleukin-10

K. Ozawa, M. Urabe, S. Muto, 2015, Laboratory Investigation.

Self-amplification system for recombinant adeno-associated virus production.

Y. Saga, K. Ozawa, M. Urabe, 2000, Biochemical and biophysical research communications.

Complete restoration of phenylalanine oxidation in phenylketonuria mouse by a self‐complementary adeno‐associated virus vector

H. Yoshikawa, H. Mizukami, K. Ozawa, 2011, The journal of gene medicine.

Development and characterization of an antisense-mediated prepackaging cell line for adeno-associated virus vector production.

H. Mizukami, K. Ozawa, Y. Hanazono, 2001, Biochemical and biophysical research communications.

Targeted Integration of Foreign DNA Into a Defined Locus on Chromosome 19 in K562 Cells Using AAV-Derived Components

H. Mizukami, K. Ozawa, M. Urabe, 2001, International journal of hematology.

Adeno-associated virus Rep proteins target DNA sequences to a unique locus in the human genome

G. Natsoulis, K. Ozawa, M. Urabe, 1997, Journal of virology.

Recovery of neurogenic amines in phenylketonuria mice after liver-targeted gene therapy

H. Mizukami, K. Ozawa, M. Urabe, 2012, Neuroreport.

Adeno-associated viral vector-mediated gene therapy of ischemia-induced neuronal death.

N. Kawai, H. Mizukami, K. Ozawa, 2002, Methods in enzymology.

A variant of MDCK cell line which restricted growth of influenza viruses mainly through suppression of viral primary transcription

H. Jin, M. Urabe, K. Tobita, 2005, Archives of Virology.

Use of competitive PCR to estimate the level of NS gene persisting in MDCK cells which survived productive replication of a mutant of influenza virus A/WSN.

M. Urabe, K. Tobita, T. Tanaka, 1994, Journal of virological methods.

Her2 expression can predict the survival of patients with salivary duct carcinoma

M. Urabe, Masashi Suzuki, T. Kawano, 2022, Clinical Immunology Communications.

Apoptosis-mediated regulation of recombinant human granulocyte colony-stimulating factor production by genetically engineered fibroblasts

H. Mano, K. Ozawa, A. Kakizuka, 1998, Gene Therapy.

Cell and gene therapy using mesenchymal stem cells (MSCs).

Kazuya Sato, H. Mizukami, K. Ozawa, 2008, Journal of autoimmunity.

Development of a mouse model for lymph node metastasis with endometrial cancer

Y. Saga, Mitsuaki Suzuki, H. Mizukami, 2011, Cancer science.

Retroviral vector‐producing mesenchymal stem cells for targeted suicide cancer gene therapy

H. Mizukami, K. Ozawa, M. Urabe, 2009, The journal of gene medicine.

Expression of HGF/NK4 in ovarian cancer cells suppresses intraperitoneal dissemination and extends host survival

T. Nakamura, Y. Saga, H. Mizukami, 2001, Gene Therapy.

TSLP activates the production of IFN-γ via CD8-positive T cells in recurrent tonsillitis

M. Urabe, Masashi Suzuki, T. Kawano, 2022, Clinical Immunology Communications.

NF-κB activity regulates mesenchymal stem cell accumulation at tumor sites.

Y. Saga, H. Mizuguchi, H. Mizukami, 2013, Cancer research.

A selective amplifier gene for tamoxifen‐inducible expansion of hematopoietic cells

K. Matsuda, K. Ozawa, I. Kato, 1999, The journal of gene medicine.

Fas and Mutant Estrogen Receptor Chimeric Gene: A Novel Suicide Vector for Tamoxifen‐inducible Apoptosis

K. Ozawa, A. Kakizuka, M. Urabe, 1998, Japanese journal of cancer research : Gann.

Soluble FLT-1 expression suppresses carcinomatous ascites in nude mice bearing ovarian cancer.

Y. Taketani, M. Shibuya, T. Tsuruo, 2002, Cancer research.

Induction of Robust Immune Responses against Human Immunodeficiency Virus Is Supported by the Inherent Tropism of Adeno-Associated Virus Type 5 forDendritic Cells

H. Mizukami, K. Ozawa, M. Urabe, 2006, Journal of Virology.

Eradication of cervical cancer in vivo by an AAV vector that encodes shRNA targeting human papillomavirus type 16 E6/E7

Y. Saga, Mitsuaki Suzuki, H. Mizukami, 2018, International journal of oncology.

Separate control of rep and cap expression using mutant and wild-type LoxP sequences and improved packaging system for adeno-associated virus vector production

H. Mizukami, K. Ozawa, M. Urabe, 2004, Molecular biotechnology.

DNA/Calcium phosphate precipitates mixed with medium are stable and maintain high transfection efficiency.

K. Ozawa, M. Urabe, A. Kume, 2000, Analytical biochemistry.

Higher Transduction Efficiency of AAV5 to Neural Stem Cells and Immature Neurons in Gerbil Dentate Gyrus Compared to AAV2 and rh10.

A. Inutsuka, K. Kawai, H. Mizukami, 2021, Human gene therapy.

CRISPR/Cas9-mediated cervical cancer treatment targeting human papillomavirus E6

Y. Saga, H. Mizukami, S. Matsubara, 2018, Oncology letters.

Optimization of adeno-associated virus vector-mediated gene transfer to the respiratory tract

Y. Saga, Y. Sugiyama, H. Mizukami, 2017, Gene Therapy.

Biochemical Characterization of Junonia coenia Densovirus Nonstructural Protein NS-1

R. Kotin, M. Urabe, M. Bergoin, 2002, Journal of Virology.

Utility of intraperitoneal administration as a route of AAV serotype 5 vector‐mediated neonatal gene transfer

H. Yoshikawa, S. Madoiwa, J. Mimuro, 2006, The journal of gene medicine.

A novel recombinant adeno-associated virus vaccine induces a long-term humoral immune response to human immunodeficiency virus.

H. Mizukami, K. Ozawa, M. Urabe, 2001, Human gene therapy.

Removal of empty capsids from type 1 adeno-associated virus vector stocks by anion-exchange chromatography potentiates transgene expression.

H. Mizukami, K. Ozawa, M. Urabe, 2006, Molecular therapy : the journal of the American Society of Gene Therapy.

Scalable Generation of High-Titer Recombinant Adeno-Associated Virus Type 5 in Insect Cells

R. Kotin, H. Mizukami, K. Ozawa, 2006, Journal of Virology.

Insect cells as a factory to produce adeno-associated virus type 2 vectors.

R. Kotin, M. Urabe, Chuantian Ding, 2002, Human gene therapy.

An R132H Mutation in Isocitrate Dehydrogenase 1 Enhances p21 Expression and Inhibits Phosphorylation of Retinoblastoma Protein in Glioma Cells

H. Mizukami, K. Ozawa, M. Urabe, 2013, Neurologia medico-chirurgica.

A Phase I Study of Aromatic L-Amino Acid Decarboxylase Gene Therapy for Parkinson's Disease.

H. Mizukami, K. Ozawa, M. Urabe, 2010, Molecular therapy : the journal of the American Society of Gene Therapy.

Comprehensive Metabolomic Analysis of IDH1R132H Clinical Glioma Samples Reveals Suppression of β-oxidation Due to Carnitine Deficiency

K. Kawai, E. Sakashita, H. Endo, 2019, Scientific Reports.

The Tol2 transposon system mediates the genetic engineering of T-cells with CD19-specific chimeric antigen receptors for B-cell malignancies

K. Kawakami, Y. Saga, H. Mizukami, 2014, Gene Therapy.

Functional Analysis of an Inducible Promoter Driven by Activation Signals from a Chimeric Antigen Receptor

H. Mizukami, K. Ozawa, M. Urabe, 2018, Molecular therapy oncolytics.

CD19 target-engineered T-cells accumulate at tumor lesions in human B-cell lymphoma xenograft mouse models.

M. Sadelain, H. Mizukami, K. Ozawa, 2013, Biochemical and biophysical research communications.

γ-Rays enhance rAAV-mediated transgene expression and cytocidal effect of AAV-HSVtk/ganciclovir on cancer cells

H. Mizukami, K. Ozawa, M. Urabe, 2001, Cancer Gene Therapy.

Adeno-associated virus vector-mediated bcl-2 gene transfer into post-ischemic gerbil brain in vivo: prospects for gene therapy of ischemia-induced neuronal death

N. Kawai, K. Ozawa, M. Urabe, 2000, Gene Therapy.

Translocation and cleavage of myocardial dystrophin as a common pathway to advanced heart failure: a scheme for the progression of cardiac dysfunction.

K. Ozawa, T. Ebisawa, J. Schaper, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Efficient gene transfer into cardiac myocytes using adeno-associated virus (AAV) vectors.

U. Ikeda, K. Shimada, T. Takizawa, 1998, Journal of molecular and cellular cardiology.

Prevention of diabetic retinopathy by intraocular soluble flt-1 gene transfer in a spontaneously diabetic rat model.

H. Mizukami, K. Ozawa, M. Kawakami, 2007, International journal of molecular medicine.

A G-CSF receptor-gyrase B fusion gene: A new type of molecular switch for expansion of genetically modified hematopoietic cells.

H. Mano, K. Ozawa, K. Ito, 1999, Biochemical and biophysical research communications.

Structure and mechanism of the primosome protein DnaT– functional structures for homotrimerization, dissociation of ssDNA from the PriB·ssDNA complex, and formation of the DnaT·ssDNA complex

T. Katayama, T. Ueda, M. Urabe, 2014, The FEBS journal.

Lysine-specific demethylase 1 inhibitors prevent teratoma development from human induced pluripotent stem cells

T. Umehara, Y. Furukawa, J. Kikuchi, 2018, Oncotarget.

Adeno-Associated Virus-Mediated Transfer of Endothelial Nitric Oxide Synthase Gene Inhibits Protein Synthesis of Rat Ventricular Cardiomyocytes

U. Ikeda, K. Shimada, K. Ozawa, 2004, Cardiovascular Drugs and Therapy.

A phase I study of aromatic L-amino acid decarboxylase gene therapy for Parkinson's disease.

H. Mizukami, K. Ozawa, M. Urabe, 2010, Molecular therapy : the journal of the American Society of Gene Therapy.

Positive and negative effects of adeno-associated virus Rep on AAVS1-targeted integration.

K. Ozawa, M. Urabe, A. Kume, 2003, The Journal of general virology.

Nitric Oxide Synthase Gene Transfer Inhibits Protein Synthesis of Rat Cardiac Mycocytes

U. Ikeda, K. Shimada, K. Ozawa, 2000 .

Hematopoietic stem cell gene therapy: a current overview.

H. Mizukami, K. Ozawa, Y. Hanazono, 1999, International journal of hematology.

Isolation and preliminary characterization of a highly cytolytic influenza B virus variant with an aberrant NS gene.

H. Goto, M. Urabe, K. Tobita, 1984, Virology.

Persistence of viral genes in a variant of MDBK cell after productive replication of a mutant of influenza virus A/WSN

M. Urabe, M. Tashiro, T. Odagiri, 2005, Archives of Virology.

MDBK cells which survived infection with a mutant of influenza virus A/WSN and subsequently received many passages contained viral M and NS genes in full length in the absence of virus production

M. Urabe, K. Tobita, T. Tanaka, 2005, Archives of Virology.

Potential application of dominant negative retinoic acid receptor genes for ex vivo expansion of hematopoietic stem cells

H. Mano, K. Ozawa, A. Kakizuka, 1999 .

Fas and Mutant Estrogen Receptor Chimeric Gene: A Novel Suicide Vector for Tamoxifen‐inducible Apoptosis

K. Ozawa, A. Kakizuka, M. Urabe, 1998, Japanese journal of cancer research : Gann.

Efficient transduction of adeno-associated virus vectors into gerbil hippocampus with an appropriate combination of viral capsids and promoters

K. Kawai, H. Mizukami, M. Urabe, 2018, Neuroscience Letters.