A. Kume

发表

Basic Studies Toward Hematopoietic Stem Cell Gene Therapy

K. Ozawa, K. Terao, Y. Hanazono, 2000 .

Long-term tracking of murine hematopoietic cells transduced with a bicistronic retrovirus containing CD24 and EGFP genes

K. Ozawa, Y. Ueda, M. Urabe, 2000, Gene Therapy.

Green Fluorescent Protein as a Selectable Marker of Retrovirally Transduced Hematopoietic Progenitors

T. Suda, K. Ozawa, A. Kume, 1999, Stem cells.

Sustained transgene expression by human cord blood derived CD34+ cells transduced with simian immunodeficiency virus agmTYO1‐based vectors carrying the human coagulation factor VIII gene in NOD/SCID mice

A. Ishiwata, S. Madoiwa, J. Mimuro, 2004, The journal of gene medicine.

Interleukin-10 expression induced by adeno-associated virus vector suppresses proteinuria in Zucker obese rats

H. Mizukami, K. Ozawa, M. Urabe, 2012, Gene Therapy.

Adenoassociated Virus–Mediated Prostacyclin Synthase Expression Prevents Pulmonary Arterial Hypertension in Rats

U. Ikeda, K. Shimada, J. Mimuro, 2007, Hypertension.

IL-21 is not necessary for anti-lymphoma effects of T cells expressing second-generation CD19-specific chimeric antigen receptors in a xenograft mouse model.

H. Mizukami, K. Ozawa, Masataka Nakamura, 2013 .

Gene Therapy for Diabetic Retinopathy in Animal Models and Humans

H. Mizukami, K. Ozawa, M. Urabe, 2011 .

Clinical Results of Sclerotherapy for Varicose Veins of Lower Extremity

A. Kume, S. Sano, N. Higashi, 1995 .

Comprehensive Metabolomic Analysis of IDH1R132H Clinical Glioma Samples Reveals Suppression of β-oxidation Due to Carnitine Deficiency

K. Kawai, E. Sakashita, H. Endo, 2019, Scientific Reports.

AAV6-Mediated IL-10 Expression in the Lung Ameliorates Bleomycin-Induced Pulmonary Fibrosis in Mice.

Y. Saga, H. Mizukami, M. Urabe, 2018, Human gene therapy.

Adeno-associated virus vector-mediated interleukin-10 gene transfer inhibits atherosclerosis in apolipoprotein E-deficient mice

U. Ikeda, K. Shimada, H. Mizukami, 2004, Gene Therapy.

Reciprocal upregulation of Notch signaling molecules in hematopoietic progenitor and mesenchymal stromal cells

H. Mizukami, K. Ozawa, T. Nagai, 2011, Journal of stem cells & regenerative medicine.

Novel anti-tumor mechanism of galanin receptor type 2 in head and neck squamous cell carcinoma cells

T. Carey, H. Mizukami, K. Ozawa, 2013, Cancer science.

Suppression of lymph node and lung metastases of endometrial cancer by muscle‐mediated expression of soluble vascular endothelial growth factor receptor‐3

Y. Saga, Mitsuaki Suzuki, H. Mizukami, 2013, Cancer science.

Protection against aminoglycoside-induced ototoxicity by regulated AAV vector-mediated GDNF gene transfer into the cochlea.

H. Mizukami, K. Ozawa, K. Sheykholeslami, 2008, Molecular therapy : the journal of the American Society of Gene Therapy.

Genomic analysis of non-ketotic hyperglycinaemia: A partial deletion of P-protein gene

K. Hiraga, A. Kume, K. Tada, 1990, Journal of Inherited Metabolic Disease.

AAV-mediated VEGF gene transfer into skeletal muscle stimulates angiogenesis and improves blood flow in a rat hindlimb ischemia model.

U. Ikeda, K. Shimada, M. Shibuya, 2002, Cardiovascular research.

Development of a modified selective amplifier gene for hematopoietic stem cell gene therapy

K. Matsuda, K. Ozawa, Y. Ueda, 1999, Gene Therapy.

Generation of donor hematolymphoid cells after rat-limb composite grafting

Y. Hoshino, A. Kume, Masafumi Takahashi, 2003, Transplantation.

Adipose tissue as a novel target for in vivo gene transfer by adeno-associated viral vectors.

J. Mimuro, Y. Sakata, H. Mizukami, 2006, Human gene therapy.

Adeno-associated virus vectors for gene transfer to the brain.

W. Lijun, H. Mizukami, K. Ozawa, 2002, Methods.

Gene therapy of Parkinson's disease using adeno-associated virus (AAV) vectors.

K. Ozawa, M. Urabe, A. Kume, 2000, Journal of neural transmission. Supplementum.

Prevention of dopaminergic neuron death by adeno-associated virus vector-mediated GDNF gene transfer in rat mesencephalic cells in vitro

K. Ozawa, K. Kiuchi, M. Urabe, 1998, Neuroscience Letters.

Adeno‐associated virus vector‐mediated systemic interleukin‐10 expression ameliorates hypertensive organ damage in Dahl salt‐sensitive rats

U. Ikeda, K. Shimada, H. Mizukami, 2008, The journal of gene medicine.

New selective amplifier genes containing c-Mpl for hematopoietic cell expansion.

K. Ozawa, N. Ageyama, K. Terao, 2003, Biochemical and biophysical research communications.

In vivo expansion of transduced murine hematopoietic cells with a selective amplifier gene

H. Mizukami, K. Ozawa, Y. Hanazono, 2003, The journal of gene medicine.

Interleukin-10 Expression Mediated by an Adeno-Associated Virus Vector Prevents Monocrotaline-Induced Pulmonary Arterial Hypertension in Rats

U. Ikeda, K. Shimada, H. Mizukami, 2007, Circulation research.

Triple transduction with adeno-associated virus vectors expressing tyrosine hydroxylase, aromatic-L-amino-acid decarboxylase, and GTP cyclohydrolase I for gene therapy of Parkinson's disease.

H. Mizukami, K. Ozawa, M. Urabe, 2000, Human gene therapy.

Gene Transfer into Rat Renal Cells Using Adeno-Associated Virus Vectors

U. Ikeda, K. Shimada, T. Takizawa, 2000, American Journal of Nephrology.

Highly regulated expression of adeno-associated virus large Rep proteins in stable 293 cell lines using the Cre/loxP switching system.

H. Mizukami, K. Ozawa, M. Urabe, 1999, The Journal of general virology.

ADENO-ASSOCIATED VIRUS (AAV) VECTOR MEDIATED TRANSGENE EXPRESSION IN CELL LINE DERIVED FROM MAXILLARY CANCER

K. Ozawa, M. Urabe, A. Kume, 1999 .

Efficient Production of Adeno‐associated Virus Vectors Using Split‐type Helper Plasmids

K. Ozawa, M. Urabe, A. Kume, 1999, Japanese journal of cancer research : Gann.

A switching system regulating subcellular localization of nuclear proteins using a viral protease.

K. Ozawa, M. Urabe, A. Kume, 1999, Biochemical and biophysical research communications.

Isolation and characterization of s-myc, a member of the rat myc gene family.

S. Y. Lee, Y. Kuchino, A. Kume, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Expansion of genetically corrected neutrophils in chronic granulomatous disease mice by cotransferring a therapeutic gene and a selective amplifier gene

H. Mizukami, K. Ozawa, H. Moriwaki, 2004, Gene Therapy.

Green fluorescent protein-transgenic rat: a tool for organ transplantation research.

A. Kume, N. Kasai, R. Takahashi, 2001, Biochemical and biophysical research communications.

Suicide gene therapy using AAV-HSVtk/ganciclovir in combination with irradiation results in regression of human head and neck cancer xenografts in nude mice

H. Mizukami, K. Ozawa, Y. Hanazono, 2003, Gene Therapy.

Self-amplification system for recombinant adeno-associated virus production.

Y. Saga, K. Ozawa, M. Urabe, 2000, Biochemical and biophysical research communications.

Complete restoration of phenylalanine oxidation in phenylketonuria mouse by a self‐complementary adeno‐associated virus vector

H. Yoshikawa, H. Mizukami, K. Ozawa, 2011, The journal of gene medicine.

Development and characterization of an antisense-mediated prepackaging cell line for adeno-associated virus vector production.

H. Mizukami, K. Ozawa, Y. Hanazono, 2001, Biochemical and biophysical research communications.

Targeted Integration of Foreign DNA Into a Defined Locus on Chromosome 19 in K562 Cells Using AAV-Derived Components

H. Mizukami, K. Ozawa, M. Urabe, 2001, International journal of hematology.

Non-ketotic hyperglycinemia: a life-threatening disorder in the neonate.

A. Kume, K. Narisawa, K. Tada, 1992, Early human development.

A soluble CAR‐SCF fusion protein improves adenoviral vector‐mediated gene transferto c‐Kit‐positive hematopoietic cells

H. Mizuguchi, T. Hayakawa, H. Mizukami, 2003, The journal of gene medicine.

Recovery of neurogenic amines in phenylketonuria mice after liver-targeted gene therapy

H. Mizukami, K. Ozawa, M. Urabe, 2012, Neuroreport.

Activation of Maf/AP-1 Repressor Bach2 by Oxidative Stress Promotes Apoptosis and Its Interaction with Promyelocytic Leukemia Nuclear Bodies*

E. Ito, Masayuki Yamamoto, K. Igarashi, 2002, The Journal of Biological Chemistry.

Distinct patterns of gene transfer to gerbil hippocampus with recombinant adeno-associated virus type 2 and 5

H. Mizukami, K. Ozawa, Y. Hanazono, 2003, Neuroscience Letters.

Adeno-associated viral vector-mediated gene therapy of ischemia-induced neuronal death.

N. Kawai, H. Mizukami, K. Ozawa, 2002, Methods in enzymology.

In vivo expansion of gene‐modified hematopoietic cells by a novel selective amplifier gene utilizing the erythropoietin receptor as a molecular switch

K. Ozawa, N. Ageyama, K. Terao, 2004, The journal of gene medicine.

Reduction of CTLL‐2 cytotoxicity by induction of apoptosis with a Fas‐estrogen receptor chimera

H. Mizukami, K. Ozawa, Y. Hanazono, 2003, Cancer science.

Large-scale production of recombinant viruses by use of a large culture vessel with active gassing.

H. Mizukami, K. Ozawa, A. Kume, 2005, Human gene therapy.

SOLUBLE ST 2 BLOCKS IL-33 SIGNALING IN ALLERGIC AIRWAY INFLAMMATION

M. Hayakawa, S. Tominaga, Hiroko Hayakawa, 2007 .

Apoptosis-mediated regulation of recombinant human granulocyte colony-stimulating factor production by genetically engineered fibroblasts

H. Mano, K. Ozawa, A. Kakizuka, 1998, Gene Therapy.

Cell and gene therapy using mesenchymal stem cells (MSCs).

Kazuya Sato, H. Mizukami, K. Ozawa, 2008, Journal of autoimmunity.

Development of a mouse model for lymph node metastasis with endometrial cancer

Y. Saga, Mitsuaki Suzuki, H. Mizukami, 2011, Cancer science.

Retroviral vector‐producing mesenchymal stem cells for targeted suicide cancer gene therapy

H. Mizukami, K. Ozawa, M. Urabe, 2009, The journal of gene medicine.

In situ generation of pseudotyped retroviral progeny by adenovirus‐mediated transduction of tumor cells enhances the killing effect of HSV‐tk suicide gene therapy in vitro and in vivo

N. Caplen, K. Ozawa, H. Hamada, 2004, The journal of gene medicine.

Expression of HGF/NK4 in ovarian cancer cells suppresses intraperitoneal dissemination and extends host survival

T. Nakamura, Y. Saga, H. Mizukami, 2001, Gene Therapy.

Focal adhesion kinase upregulated by granulocyte-macrophage colony-stimulating factor but not by interleukin-3 in differentiating myeloid cells.

H. Nishiura, T. Suda, A. Kume, 1997, Blood.

NF-κB activity regulates mesenchymal stem cell accumulation at tumor sites.

Y. Saga, H. Mizuguchi, H. Mizukami, 2013, Cancer research.

Efficient gene transduction in pigs and macaques with the engineered AAV vector AAV.GT5 for hemophilia B gene therapy

N. Sata, M. Hayakawa, T. Ohmori, 2022, bioRxiv.

Cutaneous infiltration in acute promyelocytic leukemia.

Y. Furukawa, A. Kume, N. Higashi, 1997, Journal of the American Academy of Dermatology.

In vivo selective expansion of gene-modified hematopoietic cells in a nonhuman primate model

K. Ozawa, N. Ageyama, K. Terao, 2002, Gene Therapy.

Gene therapy for chronic granulomatous disease.

M. Dinauer, A. Kume, 2000, The Journal of laboratory and clinical medicine.

Introduction of the green fluorescent protein gene into hematopoietic stem cells results in prolonged discrepancy of in vivo transduction levels between bone marrow progenitors and peripheral blood cells in nonhuman primates

K. Ozawa, N. Ageyama, K. Terao, 2002, The journal of gene medicine.

A selective amplifier gene for tamoxifen‐inducible expansion of hematopoietic cells

K. Matsuda, K. Ozawa, I. Kato, 1999, The journal of gene medicine.

Selective growth advantage of wild-type lymphocytes in X-linked SCID recipients

K. Sugamura, H. Mizukami, K. Ozawa, 2002, Bone Marrow Transplantation.

Cyclosporin A (CYA) Therapy For Mixed Connective Tissue Disease (MCTD)

A. Kume, S. Sano, N. Higashi, 1995 .

Allergic contact dermatitis due to diclofenac and indomethacin

A. Kume, N. Higashi, K. Ueda, 1998, Contact dermatitis.

A Case of Chronic Actinic Dermatitis due to Cabbage (Brassica oleracea var capitata)

A. Kume, N. Higashi, T. Taniguchi, 2001 .

Small-dose Itraconazole Pulse Therapy in the Treatment of Onychomycosis and Itraconazole Levels in the Nail

A. Kume, N. Higashi, K. Ueda, 1999 .

Follow-up of PSS Patients Treated with Cyclosporin A

K. Yoshikawa, A. Kume, K. Ueda, 1992 .

Kinetics and effect of integrin expression on human CD34(+) cells during murine leukemia virus-derived retroviral transduction with recombinant fibronectin for stem cell gene therapy.

N. Kiyokawa, Y. Katagiri, J. Fujimoto, 2009, Human gene therapy.

Clinical and Histopathological Study of Pseudo-mycotic Onychia

A. Kume, N. Higashi, K. Ueda, 1997 .

The glycine cleavage system. The coupled expression of the glycine decarboxylase gene and the H-protein gene in the chicken.

K. Hiraga, A. Kume, S. Kure, 1991, The Journal of biological chemistry.

The impaired expression of glycine decarboxylase in patients with hyperglycinemias.

K. Hiraga, A. Kume, K. Tada, 1988, Biochemical and biophysical research communications.

Fas and Mutant Estrogen Receptor Chimeric Gene: A Novel Suicide Vector for Tamoxifen‐inducible Apoptosis

K. Ozawa, A. Kakizuka, M. Urabe, 1998, Japanese journal of cancer research : Gann.

Soluble FLT-1 expression suppresses carcinomatous ascites in nude mice bearing ovarian cancer.

Y. Taketani, M. Shibuya, T. Tsuruo, 2002, Cancer research.

High-level reconstitution of respiratory burst activity in a human X-linked chronic granulomatous disease (X-CGD) cell line and correction of murine X-CGD bone marrow cells by retroviral-mediated gene transfer of human gp91phox.

M. Dinauer, A. Kume, H. Björgvinsdóttir, 1996, Blood.

A phase 3, multicenter, randomized, double‐blind, vehicle‐controlled, parallel‐group study of 5% sofpironium bromide (BBI‐4000) gel in Japanese patients with primary axillary hyperhidrosis

A. Kume, H. Yokozeki, Shinichi Takayama, 2021, The Journal of dermatology.

Soluble ST2 Blocks Interleukin-33 Signaling in Allergic Airway Inflammation*

M. Hayakawa, S. Tominaga, Hiroko Hayakawa, 2007, Journal of Biological Chemistry.

Selective Expansion of Transduced Cells for Hematopoietic Stem Cell Gene Therapy

H. Mizukami, Y. Hanazono, A. Kume, 2002, International journal of hematology.

Retrovirus-mediated reconstitution of respiratory burst activity in X-linked chronic granulomatous disease cells.

M. Dinauer, A. Kume, 1994, Blood.

Eradication of cervical cancer in vivo by an AAV vector that encodes shRNA targeting human papillomavirus type 16 E6/E7

Y. Saga, Mitsuaki Suzuki, H. Mizukami, 2018, International journal of oncology.

Highly efficient gene transfer into primate embryonic stem cells with a simian lentivirus vector.

K. Ozawa, N. Nakatsuji, Y. Hanazono, 2002, Molecular therapy : the journal of the American Society of Gene Therapy.

Persistent phenotypic correction of central diabetes insipidus using adeno-associated virus vector expressing arginine-vasopressin in Brattleboro rats.

H. Mizukami, K. Ozawa, S. Ishibashi, 2003, Molecular therapy : the journal of the American Society of Gene Therapy.

Suppression of ovarian cancer by muscle‐mediated expression of soluble VEGFR‐1/Flt‐1 using adeno‐associated virus serotype 1‐derived vector

Y. Saga, Mitsuaki Suzuki, H. Mizukami, 2007, International journal of cancer.

Separate control of rep and cap expression using mutant and wild-type LoxP sequences and improved packaging system for adeno-associated virus vector production

H. Mizukami, K. Ozawa, M. Urabe, 2004, Molecular biotechnology.

Interleukin-10-mediated inhibition of angiogenesis and tumor growth in mice bearing VEGF-producing ovarian cancer.

Y. Saga, Mitsuaki Suzuki, H. Mizukami, 2003, Cancer research.

Cancer Tumor Growth in Mice Bearing VEGF-producing Ovarian Interleukin-10-mediated Inhibition of Angiogenesis and Updated Version

Y. Saga, Mitsuaki Suzuki, H. Mizukami, 2003 .

Delayed delivery of AAV-GDNF prevents nigral neurodegeneration and promotes functional recovery in a rat model of Parkinson's disease

H. Mizukami, K. Ozawa, Y. Hanazono, 2002, Gene Therapy.

gene transfer of human gp91phox correction of murine X-CGD bone marrow cells by retroviral-mediated linked chronic granulomatous disease (X-CGD) cell line and High-level reconstitution of respiratory burst activity in a human X-

M. Dinauer, A. Kume, H. Björgvinsdóttir, 2011 .

DNA/Calcium phosphate precipitates mixed with medium are stable and maintain high transfection efficiency.

K. Ozawa, M. Urabe, A. Kume, 2000, Analytical biochemistry.

Intramuscular injection of AAV-GDNF results in sustained expression of transgenic GDNF, and its delivery to spinal motoneurons by retrograde transport

H. Mizukami, K. Ozawa, Y. Hanazono, 2003, Neuroscience Research.

Gene Therapy with Virus Vectors for specific Disease of the Nervous System

H. Mizukami, K. Ozawa, Y. Hanazono, 2003 .

Adeno-associated viral vectors for Parkinson's disease.

H. Mizukami, K. Ozawa, Y. Hanazono, 2003, International review of neurobiology.

Behavioral recovery in a primate model of Parkinson's disease by triple transduction of striatal cells with adeno-associated viral vectors expressing dopamine-synthesizing enzymes.

M. Matsumura, H. Mizukami, K. Ozawa, 2002, Human gene therapy.

Targeting of adenoviral vector to immature hematopoietic cells mediated by a soluble CAR fusion protein

K. Ozawa, Y. Hanazono, A. Kume, 2003 .

A histone deacetylase inhibitor enhances recombinant adeno-associated virus-mediated gene expression in tumor cells.

H. Mizukami, K. Ozawa, A. Kume, 2006, Molecular therapy : the journal of the American Society of Gene Therapy.

Photo-sensitive Drug Eruption from Puruzennid®(Sennoside)

A. Kume, S. Sano, N. Higashi, 1994 .

Reversible integration of the dominant negative retinoid receptor gene for ex vivo expansion of hematopoietic stem/progenitor cells.

H. Mizukami, K. Ozawa, M. Muramatsu, 2001, Biochemical and biophysical research communications.

Optimization of adeno-associated virus vector-mediated gene transfer to the respiratory tract

Y. Saga, Y. Sugiyama, H. Mizukami, 2017, Gene Therapy.

Utility of intraperitoneal administration as a route of AAV serotype 5 vector‐mediated neonatal gene transfer

H. Yoshikawa, S. Madoiwa, J. Mimuro, 2006, The journal of gene medicine.

The seroprevalence of neutralizing antibodies against the adeno-associated virus capsids in Japanese hemophiliacs

M. Hayakawa, S. Ishikawa, T. Ohmori, 2022, medRxiv.

Removal of empty capsids from type 1 adeno-associated virus vector stocks by anion-exchange chromatography potentiates transgene expression.

H. Mizukami, K. Ozawa, M. Urabe, 2006, Molecular therapy : the journal of the American Society of Gene Therapy.

[Case report of sinus histiocytosis with massive lymphadenopathy in a Japanese male with symptoms of dyspnea and visual disturbance].

A. Kume, H. Yamabe, M. Iwanaga, 1984, Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society.

Scalable Generation of High-Titer Recombinant Adeno-Associated Virus Type 5 in Insect Cells

R. Kotin, H. Mizukami, K. Ozawa, 2006, Journal of Virology.

Genomic organization of regions that regulate chicken glycine decarboxylase gene transcription: physiological and pathological implications.

D. Sikdar, K. Hiraga, A. Kume, 2009, Gene.

Specific and efficient transduction of Cochlear inner hair cells with recombinant adeno-associated virus type 3 vector.

H. Mizukami, K. Ozawa, K. Takeuchi, 2005, Molecular therapy : the journal of the American Society of Gene Therapy.

An R132H Mutation in Isocitrate Dehydrogenase 1 Enhances p21 Expression and Inhibits Phosphorylation of Retinoblastoma Protein in Glioma Cells

H. Mizukami, K. Ozawa, M. Urabe, 2013, Neurologia medico-chirurgica.

Neuroprotective Effects of Glial Cell Line-Derived Neurotrophic Factor Mediated by an Adeno-Associated Virus Vector in a Transgenic Animal Model of Amyotrophic Lateral Sclerosis

H. Mizukami, K. Ozawa, Y. Hanazono, 2002, The Journal of Neuroscience.

The glycine cleavage system. Molecular cloning of the chicken and human glycine decarboxylase cDNAs and some characteristics involved in the deduced protein structures.

K. Hiraga, A. Kume, S. Kure, 1991, The Journal of biological chemistry.

A Phase I Study of Aromatic L-Amino Acid Decarboxylase Gene Therapy for Parkinson's Disease.

H. Mizukami, K. Ozawa, M. Urabe, 2010, Molecular therapy : the journal of the American Society of Gene Therapy.

Comprehensive Metabolomic Analysis of IDH1R132H Clinical Glioma Samples Reveals Suppression of β-oxidation Due to Carnitine Deficiency

K. Kawai, E. Sakashita, H. Endo, 2019, Scientific Reports.

The Tol2 transposon system mediates the genetic engineering of T-cells with CD19-specific chimeric antigen receptors for B-cell malignancies

K. Kawakami, Y. Saga, H. Mizukami, 2014, Gene Therapy.

One of the two genomic copies of the glycine decarboxylase cDNA has been deleted at a 5' region in a patient with nonketotic hyperglycinemia.

K. Hiraga, A. Kume, K. Tada, 1990, Biochemical and biophysical research communications.

CD19 target-engineered T-cells accumulate at tumor lesions in human B-cell lymphoma xenograft mouse models.

M. Sadelain, H. Mizukami, K. Ozawa, 2013, Biochemical and biophysical research communications.

γ-Rays enhance rAAV-mediated transgene expression and cytocidal effect of AAV-HSVtk/ganciclovir on cancer cells

H. Mizukami, K. Ozawa, M. Urabe, 2001, Cancer Gene Therapy.

Laboratory Findings of Patients with Drug Eruptions; Changes of Data before and after Provocative Test

A. Kume, N. Higashi, K. Ueda, 1997 .

Efficient gene transfer into cardiac myocytes using adeno-associated virus (AAV) vectors.

U. Ikeda, K. Shimada, T. Takizawa, 1998, Journal of molecular and cellular cardiology.

Prevention of diabetic retinopathy by intraocular soluble flt-1 gene transfer in a spontaneously diabetic rat model.

H. Mizukami, K. Ozawa, M. Kawakami, 2007, International journal of molecular medicine.

A Case of Ulcerative Skin Lesion in a Healthy Man due to Pseudomonas Aeruginosa

A. Kume, N. Higashi, S. Hazano, 1993 .

A G-CSF receptor-gyrase B fusion gene: A new type of molecular switch for expansion of genetically modified hematopoietic cells.

H. Mano, K. Ozawa, K. Ito, 1999, Biochemical and biophysical research communications.

Improved vector, pHSG664, for direct streptomycin-resistance selection: cDNA cloning with G:C-tailing procedure and subcloning of double-digest DNA fragments.

A. Kume, T. Hashimoto-Gotoh, S. Takeshita, 1986, Gene.

Adeno-Associated Virus-Mediated Transfer of Endothelial Nitric Oxide Synthase Gene Inhibits Protein Synthesis of Rat Ventricular Cardiomyocytes

U. Ikeda, K. Shimada, K. Ozawa, 2004, Cardiovascular Drugs and Therapy.

A phase I study of aromatic L-amino acid decarboxylase gene therapy for Parkinson's disease.

H. Mizukami, K. Ozawa, M. Urabe, 2010, Molecular therapy : the journal of the American Society of Gene Therapy.

Systemic delivery of IL-10 by an AAV vector prevents vascular remodeling and end-organ damage in stroke-prone spontaneously hypertensive rat

U. Ikeda, H. Mizukami, K. Ozawa, 2009, Gene Therapy.

Positive and negative effects of adeno-associated virus Rep on AAVS1-targeted integration.

K. Ozawa, M. Urabe, A. Kume, 2003, The Journal of general virology.

Promoter effects of adeno-associated viral vector for transgene expression in the cochlea in vivo

K. Ozawa, A. Kume, Yuhe Liu, 2007, Experimental & Molecular Medicine.

Treatment for Ingrown Toenail with Sculptured Nail

A. Kume, S. Sano, N. Higashi, 1995 .

Long-term correction of hyperphenylalaninemia by AAV-mediated gene transfer leads to behavioral recovery in phenylketonuria mice

H. Mizukami, K. Ozawa, Y. Matsubara, 2004, Gene Therapy.

A case of type I allergy due to cochineal extract

A. Kume, N. Higashi, K. Ueda, 1999 .

A phase III, 52‐week, open‐label study to evaluate the safety and efficacy of 5% sofpironium bromide (BBI‐4000) gel in Japanese patients with primary axillary hyperhidrosis

A. Kume, H. Yokozeki, T. Hanafusa, 2021, The Journal of dermatology.

Nitric Oxide Synthase Gene Transfer Inhibits Protein Synthesis of Rat Cardiac Mycocytes

U. Ikeda, K. Shimada, K. Ozawa, 2000 .

Two Cases of B Cell Lymphoma Two Elderly Women with La: rge Facial Tumors

A. Kume, N. Higashi, K. Ueda, 2000 .

Hematopoietic stem cell gene therapy: a current overview.

H. Mizukami, K. Ozawa, Y. Hanazono, 1999, International journal of hematology.

Aspects of Gene Therapy Products Using Current Genome-Editing Technology in Japan

H. Mizuguchi, K. Ozawa, K. Mitani, 2020, Human gene therapy.

Lymphold reconstitution in X-linked severe combined immunodeficient mice by retrovirus-mediated gene transfer

K. Sugamura, H. Mizukami, K. Ozawa, 2002 .

A novel strategy for the tumor angiogenesis-targeted gene therapy: Generation of angiostatin from endogenous plasminogen by protease gene transfer

Y. Saga, H. Mano, K. Matsuda, 2000, Cancer Gene Therapy.

Photosensitive Drug Eruption due to Cardenalin® (doxazosin mesilate)

A. Kume, N. Higashi, K. Ueda, 1997 .

Median Rhomboid Glossitis and Candidal Infection

A. Kume, N. Higashi, S. Hazano, 1992 .

Biodistribution studies: understanding international expectations

Leelee Ong, A. Kume, N. Ferry, 2016, Molecular Therapy. Methods & Clinical Development.

Potential application of dominant negative retinoic acid receptor genes for ex vivo expansion of hematopoietic stem cells

H. Mano, K. Ozawa, A. Kakizuka, 1999 .

Fas and Mutant Estrogen Receptor Chimeric Gene: A Novel Suicide Vector for Tamoxifen‐inducible Apoptosis

K. Ozawa, A. Kakizuka, M. Urabe, 1998, Japanese journal of cancer research : Gann.