D. Christophe

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Critical residues of the homeodomain involved in contacting DNA bases also specify the nuclear accumulation of thyroid transcription factor-1.

P. Roger, C. Christophe-Hobertus, V. Duquesne, 1999, European journal of biochemistry.

Nuclear targeting of proteins: how many different signals?

C. Christophe-Hobertus, B. Pichon, D. Christophe, 2000, Cellular signalling.

Functional study of the human thyroid peroxidase gene promoter.

M. Abramowicz, D. Christophe, G. Vassart, 1992, European journal of biochemistry.

Methylation and expression of the human thyroglobulin gene.

D. Christophe, G. Vassart, F. Libert, 1986, Biochemical and biophysical research communications.

Structural organization of the 5' region of the human thyroglobulin gene.

D. Christophe, G. Vassart, H. Targovnik, 1984, European journal of biochemistry.

Isolation and characterization of a fragment of rat thyroglobulin gene.

J. Pasteels, J. Dumont, D. Christophe, 1982, Biochemical and biophysical research communications.

Thyroid Function and Growth Regulation under Normal and Abnormal Conditions

P. Roger, D. Christophe, M. Pisarev, 2012, Journal of thyroid research.

TTF-2 does not appear to be a key mediator of the effect of cyclic AMP on thyroglobulin gene transcription in primary cultured dog thyrocytes.

B. Pichon, D. Christophe, A. Donda, 1998, Biochemical and biophysical research communications.

Characterization of a novel loss of function mutation of PAX8 in a familial case of congenital hypothyroidism with in-place, normal-sized thyroid.

J. Parma, M. Abramowicz, S. Costagliola, 2004, The Journal of clinical endocrinology and metabolism.

Ontogeny, Anatomy, Metabolism and Physiology of the Thyroid

G. Chrousos, R. Opitz, J. Dumont, 2015 .

Thyroid-specific and cAMP-dependent hypersensitive regions in thyroglobulin gene chromatin.

P. Stordeur, D. Christophe, G. Vassart, 1988, European journal of biochemistry.

Structural and functional characterization of the two human ThOX/Duox genes and their 5′-flanking regions

F. Miot, D. Christophe, D. Wang, 2004, Molecular and Cellular Endocrinology.

Pax 8 expression in primary cultured dog thyrocyte is increased by cyclic AMP.

D. Christophe, G. Vassart, Pierre Van Renterghem, 1996, Biochimica et biophysica acta.

Study of TTF-1 gene expression in dog thyrocytes in primary culture

S. Dremier, D. Christophe, G. Vassart, 1995, Molecular and Cellular Endocrinology.

Identification of the gene encoding Brain Cell Membrane Protein 1 (BCMP1), a putative four-transmembrane protein distantly related to the Peripheral Myelin Protein 22 / Epithelial Membrane Proteins and the Claudins

C. Christophe-Hobertus, D. Christophe, R. Guyon, 2001, BMC Genomics.

Thyroid Transcription Factor-1 Activity Is Required For the Proliferation of Human Thyroid Cancer Cells 8505C

C. Christophe-Hobertus, D. Christophe, F. Libert, 2015 .

Functional inactivation of thyroid transcription factor-1 in PCCl3 thyroid cells

C. Christophe-Hobertus, D. Christophe, F. Libert, 2012, Molecular and Cellular Endocrinology.

Chap 75. Thyroid regulatory factors

J. Dumont, J. Jameson, C. Maenhaut, 2015 .

Identification of a thyroid-specific and cAMP-responsive enhancer in the upstream sequences of the human thyroglobulin promoter.

D. Christophe, G. Vassart, V. Berg, 1996, Biochimica et biophysica acta.

Molecular cloning of the 8000-base thyroglobulin structural gene.

D. Christophe, G. Vassart, V. Pohl, 2005, European journal of biochemistry.

Functional role of TTF‐1 binding sites in bovine thyroglobulin promoter

H. Francis-Lang, D. Christophe, G. Vassart, 1992, FEBS letters.

Cloning and sequence analysis of TFE, a helix-loop-helix transcription factor able to recognize the thyroglobulin gene promoter in vitro.

D. Christophe, G. Vassart, A. Donda, 1991, Nucleic acids research.

Sequences downstream of the bHLH domain of the Xenopus hairy-related transcription factor-1 act as an extended dimerization domain that contributes to the selection of the partners.

E. Bellefroid, T. Pieler, B. Pichon, 2004, Developmental biology.

Identification of BOIP, a novel cDNA highly expressed during spermatogenesis that encodes a protein interacting with the orange domain of the hairy‐related transcription factor HRT1/Hey1 in Xenopus and mouse

A. Fischer, M. Gessler, E. Bellefroid, 2003, Developmental dynamics : an official publication of the American Association of Anatomists.

Unmethylated thyroglobulin promoter may be repressed by methylation of flanking DNA sequences.

C. Christophe-Hobertus, B. Pichon, D. Christophe, 1994, Biochemical Journal.

The thyroglobulin gene evolutionary and regulatory issues

D. Christophe, G. Vassart, 1990, Trends in Endocrinology & Metabolism.

Control of thyroperoxidase and thyroglobulin transcription by cAMP: evidence for distinct regulatory mechanisms.

J. Dumont, D. Christophe, G. Vassart, 1989, Molecular endocrinology.

[Structure and expression of thyroglobulin gene].

A. Leriche, D. Christophe, G. Vassart, 1984, Annales d'endocrinologie.

cAMP-dependent binding of a trans-acting factor to the thyroglobulin promoter.

D. Christophe, G. Vassart, G. Juvenal, 1989, Biochemical and biophysical research communications.

Identification of a transcriptional enhancer upstream from the bovine thyroglobulin gene

C. Christophe-Hobertus, D. Christophe, G. Vassart, 1992, Molecular and Cellular Endocrinology.

Transcriptional repression by the bHLH-Orange factor XHRT1 does not involve the C-terminal YRPW motif.

E. Bellefroid, B. Pichon, D. Christophe, 2004, Biochimica et biophysica acta.

Thyroid peroxidase gene promoter confers TSH responsiveness to heterologous reporter genes in transfection experiments.

M. Abramowicz, D. Christophe, G. Vassart, 1990, Biochemical and biophysical research communications.

An unusually long poly(purine)-poly(pyrimidine) sequence is located upstream from the human thyroglobulin gene.

A. Bacolla, D. Christophe, G. Vassart, 1985, Nucleic acids research.

A sequence in M13 phage detects hypervariable minisatellites in human and animal DNA.

M. Georges, D. Christophe, G. Vassart, 1987, Science.

Suboptimal Enhancer Sequences Are Required for Efficient Bovine Leukemia Virus Propagation In Vivo: Implications for Viral Latency

A. Burny, C. Van Lint, R. Kettmann, 2001, Journal of Virology.

Improved synthesis of DBM paper.

D. Christophe, G. Vassart, H. Brocas, 1982, Analytical biochemistry.

Structural organization of the 5' region of the thyroglobulin gene. Evidence for intron loss and "exonization" during evolution.

J. Parma, D. Christophe, G. Vassart, 1987, Journal of molecular biology.

Identification of a cAMP-responsive region in thyroglobulin gene promoter

C. Ledent, A. Bacolla, C. Christophe-Hobertus, 1989, Molecular and Cellular Endocrinology.

Transcriptional regulation of the thyroperoxydase gene by thyrotropin and forskolin

D. Christophe, G. Vassart, F. Libert, 1988, Molecular and Cellular Endocrinology.

Effects of 2-iodohexadecanal in the physiology of thyroid cells

C. Christophe-Hobertus, D. Christophe, M. Pisarev, 2016, Molecular and Cellular Endocrinology.

Molecular cloning of bovine thyroglobulin complementary DNA. Characterization of 2500-base-pair and 1900-base-pair fragments.

F. Gannon, D. Christophe, G. Vassart, 1980, European journal of biochemistry.

Cloning of human thyroglobulin complementary DNA

D. Christophe, G. Vassart, V. Pohl, 1982, FEBS letters.

The homopurine–homopyrimidine DNA sequence flanking the thyroglobulin gene does not behave as a transcriptional diode in living cells

C. Christophe-Hobertus, D. Christophe, 2015 .

Delimitation and functional characterization of the bidirectional THOX–DUOXA promoter regions in thyrocytes

C. Christophe-Hobertus, D. Christophe, 2010, Molecular and Cellular Endocrinology.

DNA methylation and gene activity: towards the end of the debate?

B. Pichon, D. Christophe, 1994, Molecular and Cellular Endocrinology.

Two binding sites for thyroid transcription factor 1 (TTF-1) determine the activity of the bovine thyroglobulin gene upstream enhancer element

C. Christophe-Hobertus, D. Christophe, 1999, Molecular and Cellular Endocrinology.

Human, bovine, canine and rat thyroglobulin promoter sequences display species-specific differences in an in vitro study

D. Christophe, G. Vassart, A. Donda, 1993, Molecular and Cellular Endocrinology.

Isolation and characterization of the canine thyroglobulin gene promoter region.

D. Christophe, G. Vassart, A. Donda, 1991, Biochimica et biophysica acta.

Molecular cloning of Pst I fragments from rat double stranded thyroglobulin complementary DNA.

D. Christophe, G. Vassart, N. Scherberg, 1980, Biochemical and biophysical research communications.

Induction of nerve growth factor-induced gene-B (NGFI-B) as an early event in the cyclic adenosine monophosphate response of dog thyrocytes in primary culture.

I. Pirson, C. Maenhaut, B. Pichon, 1996, Endocrinology.

Structure, expression and regulation of the thyroglobulin gene

J. Parma, A. Bacolla, A. Leriche, 1985, Molecular and Cellular Endocrinology.

Distinct transcriptional effects of cAMP on 2 thyroid specific genes: thyroperoxidase and thyroglobulin.

J. Dumont, D. Christophe, G. Vassart, 1990, Hormone and metabolic research. Supplement series.

The control of thyroid-specific gene expression: what exactly have we learned as yet?

D. Christophe, 2004, Molecular and Cellular Endocrinology.

A canonical nerve growth factor-induced gene-B response element appears not to be involved in the cyclic adenosine monophosphate-dependent expression of differentiation in thyrocytes

B. Pichon, D. Christophe, G. Vassart, 1999, Molecular and Cellular Endocrinology.

Expression of a transactivation‐deficient form of thyroid transcription factor I decreases the activity of co‐transfected thyroglobulin and thyroperoxidase promoters

C. Christophe-Hobertus, B. Pichon, D. Christophe, 1996, FEBS letters.

Human Thyroid Oxidases genes promoter activity in thyrocytes does not appear to be functionally dependent on Thyroid Transcription Factor-1 or Pax8

C. Christophe-Hobertus, D. Christophe, 2007, Molecular and Cellular Endocrinology.

Bmc Medical Genetics Tm4sf10 Gene Sequencing in Xlmr Patients Identifies Common Polymorphisms but No Disease-associated Mutation

J. Gécz, C. Schwartz, M. Abramowicz, 2022 .

11 The cAMP in thyroid

A. Allgeier, M. Parmentier, C. Ledent, 1997 .

Nucleotide sequence of a putative transcription factor recognizing the thyroglobulin promoter.

D. Christophe, G. Vassart, F. Javaux, 1990, Nucleic Acids Research.

Control of thyroglobulin gene expression

J. Dumont, P. Roger, D. Christophe, 1987 .

A zinc-dependent DNA-binding activity co-operates with cAMP-responsive-element-binding protein to activate the human thyroglobulin enhancer.

D. Christophe, G. Vassart, V. Berg, 1997, Biochemical Journal.

The phylogeny, ontogeny, anatomy and regulation of the iodine metabolizing thyroid

Carine Maenhaut, Jacques Emile Dumont, J. Dumont, 2005 .

An in vitro transcription system for the study of thyroid-specific transcription.

B. Pichon, D. Christophe, 1998, Analytical biochemistry.

A method for the large-scale cloning of nuclear proteins and nuclear targeting sequences on a functional basis.

C. Christophe-Hobertus, B. Pichon, D. Christophe, 2000, Analytical biochemistry.

The cAMP in thyroid: from the TSH receptor to mitogenesis and tumorigenesis.

A. Allgeier, M. Parmentier, C. Ledent, 1997, Advances in second messenger and phosphoprotein research.