J. Janovick

P. Conn, J. Janovick, W. Lucca-Junior, 2009, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.

Parallel Regulation of Membrane Trafficking and Dominant-negative Effects by Misrouted Gonadotropin-releasing Hormone Receptor Mutants*

S. Brothers, P. Conn, J. Janovick, 2005, Journal of Biological Chemistry.

In vitro coexpression and pharmacological rescue of mutant gonadotropin-releasing hormone receptors causing hypogonadotropic hypogonadism in humans expressing compound heterozygous alleles.

P. Conn, J. Janovick, A. Ulloa-Aguirre, 2005, The Journal of clinical endocrinology and metabolism.

IN VITRO COEXPRESSION AND PHARMACOLOGICAL RESCUE OF MUTANT GNRH RECEPTORS CAUSING HYPOGONADOTROPIC HYPOGONADISM IN HUMANS EXPRESSING COMPOUND HETEROZYGOUS ALLELES

P. Conn, J. Janovick, A. Ulloa-Aguirre, 2005 .

Simultaneous and independent visualization of the gonadotropin-releasing hormone receptor and its ligand: evidence for independent processing and recycling in living cells.

A. Cornea, P. Conn, J. Janovick, 1999, Endocrinology.

Regulation of Gq/11α by the Gonadotropin-Releasing Hormone Receptor

S. Brothers, P. Conn, J. Janovick, 1997 .

Protein folding as posttranslational regulation: evolution of a mechanism for controlled plasma membrane expression of a G protein-coupled receptor.

S. Brothers, P. Conn, J. Janovick, 2006, Molecular endocrinology.

SIIp: a unique secretogranin/chromogranin of the pituitary released in response to gonadotropin-releasing hormone.

P. Conn, J. Janovick, R. Maurer, 1992, Endocrinology.

'Effective inefficiency': cellular control of protein trafficking as a mechanism of post-translational regulation.

S. Brothers, P. Conn, J. Janovick, 2006, The Journal of endocrinology.

Receptor-misrouting: an unexpectedly prevalent and rescuable etiology in gonadotropin-releasing hormone receptor-mediated hypogonadotropic hypogonadism.

P. Conn, J. Janovick, A. Leaños-Miranda, 2002, The Journal of clinical endocrinology and metabolism.

Molecular basis of hypogonadotropic hypogonadism: restoration of mutant (E(90)K) GnRH receptor function by a deletion at a distant site.

P. Conn, J. Janovick, A. Ulloa-Aguirre, 2002, The Journal of clinical endocrinology and metabolism.

A novel mouse model of hypogonadotrophic hypogonadism: N-ethyl-N-nitrosourea-induced gonadotropin-releasing hormone receptor gene mutation.

M. Justice, R. Behringer, D. Stockton, 2005, Molecular endocrinology.

Addition of Catfish Gonadotropin- Releasing Hormone (gnrh) Receptor Intracellular Carboxyl- Terminal Tail to Rat Gnrh Receptor Alters Receptor Expression and Regulation Mammalian Gnrh Receptor (gnrhr) Is Unique among G Protein-coupled Seven-transmembrane Segment Receptors Due to the Absence of an In

S. Brothers, P. Conn, J. Janovick, 2022 .

Gonadotropin-releasing hormone-stimulated intracellular Ca2+ fluctuations and luteinizing hormone release can be uncoupled from inositol phosphate production.

B. Hawes, S. Waters, P. Conn, 1992, Endocrinology.

Differential orientation of a GnRH agonist and antagonist in the pituitary GnRH receptor.

F. Haviv, P. Conn, J. Janovick, 1993, Endocrinology.

Specific identification and subcellular localization of three calmodulin-binding proteins in the rat gonadotrope: spectrin, caldesmon, and calcineurin.

C. Wooge, P. Conn, J. Janovick, 1991, Biology of reproduction.

Mechanisms mediating multiple physiological responses to gonadotropin-releasing hormone

P. Conn, J. Janovick, D. Stanislaus, 1998, Molecular and Cellular Endocrinology.

Identification of Potential Pharmacoperones Capable of Rescuing the Functionality of Misfolded Vasopressin 2 Receptor Involved in Nephrogenic Diabetes Insipidus

T. Spicer, P. Conn, J. Janovick, 2016, Journal of biomolecular screening.

Structure-activity relationships of G protein-coupled receptors.

A Ulloa-Aguirre, P. Conn, J. Janovick, 1999, Archives of medical research.

Caldesmon: a bifunctional (calmodulin and actin) binding protein which regulates stimulated gonadotropin release.

P. Conn, J. Janovick, F. Longo, 1991, Endocrinology.

The Third Intracellular Loop of the Rat Gonadotropin-Releasing Hormone Receptor Couples the Receptor to Gs- and Gq/11-Mediated Signal Transduction Pathways: Evidence from Loop Fragment Transfection in GGH3 Cells.

S. Brothers, P. Conn, J. Janovick, 1998, Endocrinology.

G-protein-coupled receptor trafficking: understanding the chemical basis of health and disease.

P. Conn, J. Janovick, A. Ulloa-Aguirre, 2006, ACS chemical biology.

Pharmacologic Rescue of Conformationally‐Defective Proteins: Implications for the Treatment of Human Disease

S. Brothers, P. Conn, J. Janovick, 2004, Traffic.

Identification of new gonadotrophin-releasing hormone partial agonists.

J. Rivier, P. Conn, J. Janovick, 2006, The Journal of endocrinology.

Mutations at the consensus phosphorylation sites in the third intracellular loop of the rat gonadotropin-releasing hormone receptor: effects on receptor ligand binding and signal transduction.

P. Conn, Xin-wei Lin, J. Janovick, 1998, Biology of reproduction.

Mutations of the Gonadotropin-Releasing Hormone Receptor Gene

P. Conn, J. Janovick, A. Ulloa-Aguirre, 2014 .

G Protein-Coupled Receptor Trafficking in Health and Disease: Lessons Learned to Prepare for Therapeutic Mutant Rescue in Vivo

P. Conn, J. Janovick, P Michael Conn, 2007, Pharmacological Reviews.

REGULATION OF GQ/11ALPHA BY THE GONADOTROPIN-RELEASING HORMONE RECEPTOR

P. Conn, J. Janovick, D. Stanislaus, 1997 .

Regulation of G(q/11)alpha by the gonadotropin-releasing hormone receptor.

S. Brothers, P. Conn, J. Janovick, 1997, Molecular endocrinology.

Structure-Activity Relations of Successful Pharmacologic Chaperones for Rescue of Naturally Occurring and Manufactured Mutants of the Gonadotropin-Releasing Hormone Receptor

J. Greer, E. Bush, P. Conn, 2003, Journal of Pharmacology and Experimental Therapeutics.

Brain gonadotropin releasing hormone receptors: localization and regulation.

P. Conn, J. Janovick, L. Jennes, 1997, Recent progress in hormone research.

Drug Library Screening for the Identification of Ionophores That Correct the Mistrafficking Disorder Associated with Oxalosis Kidney Disease

Louis Scampavia, Franck Madoux, Timothy P Spicer, 2017, SLAS discovery : advancing life sciences R & D.

Modulation of proteostasis and protein trafficking: a therapeutic avenue for misfolded G protein-coupled receptors causing disease in humans.

J. Janovick, A. Ulloa-Aguirre, 2019, Emerging topics in life sciences.

Gonadotropin and Gonadal Steroid Release in Response to a Gonadotropin-Releasing Hormone Agonist in Gqα and G11α Knockout Mice.

S. Offermanns, P. Conn, J. Janovick, 1998, Endocrinology.

Redistribution of Gq/11α in the Pituitary Gonadotrope in Response to a Gonadotropin-Releasing Hormone Agonist.

A. Cornea, P. Conn, J. Janovick, 1998, Endocrinology.

A cholera toxin-sensitive guanyl nucleotide binding protein mediates the movement of pituitary luteinizing hormone into a releasable pool: loss of this event is associated with the onset of homologous desensitization to gonadotropin-releasing hormone.

P. Conn, J. Janovick, 1993, Endocrinology.

Homologous desensitization with gonadotropin-releasing hormone (GnRH) also diminishes gonadotrope responsiveness to maitotoxin: a role for the GnRH receptor-regulated calcium ion channel in mediation of cellular desensitization.

T. Yasumoto, P. Conn, J. Janovick, 1987, Molecular endocrinology.

Pharmacological chaperones correct misfolded GPCRs and rescue function: protein trafficking as a therapeutic target.

P. Conn, J. Janovick, A. Ulloa-Aguirre, 2012, Sub-cellular biochemistry.

Development of a phenotypic high-content assay to identify pharmacoperone drugs for the treatment of primary hyperoxaluria type 1 by high-throughput screening.

T. Spicer, Yih-Tai Chen, P. Conn, 2015, Assay and drug development technologies.

Molecular cloning and expression of a type-two somatostatin receptor in goldfish brain and pituitary

P. Conn, Xin-wei Lin, J. Janovick, 2000, Molecular and Cellular Endocrinology.

Functional and morphological characterization of four cell lines derived from GH3 cells stably transfected with gonadotropin-releasing hormone receptor complementary deoxyribonucleic acid.

P. Conn, J. Janovick, U. Kaiser, 1994, Endocrinology.

Rescue of hypogonadotropic hypogonadism-causing and manufactured GnRH receptor mutants by a specific protein-folding template: misrouted proteins as a novel disease etiology and therapeutic target.

P. Conn, J. Janovick, G. Maya-Núñez, 2002, The Journal of clinical endocrinology and metabolism.

Protein homeostasis and regulation of intracellular trafficking of G protein-coupled receptors

J. Janovick, A. Hanyaloglu, A. Ulloa-Aguirre, 2020 .

A mathematical model quantifying GnRH-induced LH secretion from gonadotropes.

J J Blum, M. Reed, J. Blum, 2000, American journal of physiology. Endocrinology and metabolism.

Regulation of RGS3 and RGS10 Palmitoylation by GnRH.

S. Brothers, R. Fisher, P. Conn, 2002, Endocrinology.

Intracellular Trafficking of G Protein-Coupled Receptors to the Cell Surface Plasma Membrane in Health and Disease

J. Janovick, A. Hanyaloglu, A. Ulloa-Aguirre, 2021 .

Trafficking and quality control of the gonadotropin releasing hormone receptor in health and disease

P. Conn, J. Janovick, 2009, Molecular and Cellular Endocrinology.

Gonadotropin-releasing hormone (GnRH)-receptor coupling to inositol phosphate and prolactin production in GH3 cells stably transfected with rat GnRH receptor complementary deoxyribonucleic acid.

P. Conn, J. Janovick, 1994, Endocrinology.

Gonadotropin releasing hormone binding sites in rat hippocampus: Different structure/binding relationships compared to the anterior pituitary

P. Conn, J. Janovick, L. Jennes, 1990, Molecular and Cellular Neuroscience.

Gonadotropin-Releasing Hormone Receptor Concentration Differentially Regulates Intracellular Signaling Pathways in GGH3 Cells

P. Conn, J. Janovick, J. Pinter, 1999, Pituitary.

Simultaneous and Independent Visualization of the Gonadotropin-Releasing Hormone Receptor and Its Ligand: Evidence for Independent Processing and Recycling in Living Cells1.

A. Cornea, P. Conn, Xin-wei Lin, 1999, Endocrinology.

GH3 cells transfected with gonadotropin-releasing hormone (GnRH) receptor complementary deoxyribonucleic acid release secretogranin-II through a constitutive pathway after GnRH analog-regulated synthesis: evidence that secretory proteins do not contain a sequence that obligates processing through a

P. Conn, J. Janovick, L. Jennes, 1995, Endocrinology.

A phenotypic high throughput screening assay for the identification of pharmacoperones for the gonadotropin releasing hormone receptor.

T. Spicer, P. Conn, J. Janovick, 2014, Assay and drug development technologies.

Assay strategies for identification of therapeutic leads that target protein trafficking.

T. Spicer, P. Conn, J. Janovick, 2015, Trends in pharmacological sciences.

Regulation of G Protein-coupled Receptor Trafficking by Inefficient Plasma Membrane Expression

S. Brothers, P. Conn, J. Janovick, 2006, Journal of Biological Chemistry.

Combined modification of intracellular and extracellular loci on human gonadotropin-releasing hormone receptor provides a mechanism for enhanced expression

P. Conn, J. Janovick, G. Maya-Núñez, 2000, Endocrine.

Selection of models for the study of GnRH stimulated gonadotropin release prejudices the assignment of roles for mediators and modulators of hormone action

B. Hawes, P. Conn, J. Janovick, 1992, Molecular and Cellular Endocrinology.

Molecular Cloning and Expression of Two Type One Somatostatin Receptors in Goldfish Brain1.

S. Brothers, P. Conn, Xin-wei Lin, 1999, Endocrinology.

Drug development and the cellular quality control system.

P. Conn, J. Janovick, 2009, Trends in pharmacological sciences.

Regulation of RGS3 and RGS10 palmitoylation by GnRH.

S. Brothers, R. Fisher, P. Conn, 2002, Endocrinology.

The Intrarenal Renin-Angiotensin System: From Physiology to the Pathobiology of Hypertension and Kidney Disease

H. Kobori, M. Nangaku, L. Navar, 2007, Pharmacological Reviews.

A New Understanding of Protein Mutation Unfolds

P. Conn, J. Janovick, 2005 .

G Protein-Coupled Receptor Trafficking in Health and Disease: Lessons Learned to Prepare for Therapeutic Mutant Rescue in Vivo

P. Conn, J. Janovick, A. Ulloa-Aguirre, 2007, Pharmacological Reviews.

Evolved regulation of gonadotropin-releasing hormone receptor cell surface expression

P. Conn, J. Janovick, A. Ulloa-Aguirre, 2003, Endocrine.

Biochemical mechanism of pathogenesis of human gonadotropin-releasing hormone receptor mutants Thr104Ile and Tyr108Cys associated with familial hypogonadotropic hypogonadism

P. Conn, J. Janovick, A. Ulloa-Aguirre, 2011, Molecular and Cellular Endocrinology.

Addition of catfish gonadotropin-releasing hormone (GnRH) receptor intracellular carboxyl-terminal tail to rat GnRH receptor alters receptor expression and regulation.

S. Brothers, J. Janovick, Jan Bogerd, 1998, Molecular endocrinology.

Rescue of misrouted GnRHR mutants reveals its constitutive activity.

I. Pogozheva, A. Cornea, J. Janovick, 2012, Molecular endocrinology.

Quality control autophagy degrades soluble ERAD-resistant conformers of the misfolded membrane protein GnRHR.

D. Cyr, J. Janovick, Scott A. Houck, 2014, Molecular cell.

Gonadotropin releasing hormone agonist provokes homologous receptor microaggregation: an early event in seven-transmembrane receptor mediated signaling.

J. Janovick, P. Conn, 1996, Endocrinology.

Erratum: SIIp: A unique secretogranin chromogranin of the pituitary released in response to gonadotropin-releasing hormone (Endocrinology (1992) 130 (3033-3040))

P. Conn, J. Janovick, R. Maurer, 1992 .

Assay strategies for identification of therapeutic leads that target protein trafficking.

J. Janovick, L. Scampavia, Timothy P. Spicer, 2015, Trends in pharmacological sciences.

Therapeutic rescue of misfolded/mistrafficked mutants: automation-friendly high-throughput assays for identification of pharmacoperone drugs of GPCRs.

J. Janovick, David C. Smithson, P. M. Conn, 2013, Methods in enzymology.

Conserved mammalian gonadotropin-releasing hormone receptor carboxyl terminal amino acids regulate ligand binding, effector coupling and internalization

S. Brothers, A. Cornea, P. Conn, 2002, Molecular and Cellular Endocrinology.