D. Persons

发表

Use of the green fluorescent protein as a marker to identify and track genetically modified hematopoietic cells

A. Nienhuis, R. Wersto, J. Allay, 1998, Nature Medicine.

Retroviral-mediated transfer of the green fluorescent protein gene into murine hematopoietic cells facilitates scoring and selection of transduced progenitors in vitro and identification of genetically modified cells in vivo.

Richard J Smeyne, A. Nienhuis, R. Ashmun, 1997, Blood.

High-titer foamy virus vector transduction and integration sites of human CD34+ cell–derived SCID-repopulating cells

Yong-Dong Wang, D. Persons, M. Nasimuzzaman, 2014, Molecular therapy. Methods & clinical development.

Mobilization and Mechanism of Transcription of Integrated Self-Inactivating Lentiviral Vectors

A. Nienhuis, D. Persons, H. Hanawa, 2005, Journal of Virology.

Long noncoding RNA Saf and splicing factor 45 increase soluble Fas and resistance to apoptosis

D. Persons, J. Riberdy, A. Wilber, 2016, Oncotarget.

Hydroxyurea therapy requires HbF induction for clinical benefit in a sickle cell mouse model

K. Boyd, R. Ware, D. Persons, 2010, Haematologica.

diminish the risk for proto-oncogene activation An experimental system for the evaluation of retroviral vector design to

A. Nienhuis, B. Ryu, J. Gray, 2009 .

High levels of lymphoid expression of enhanced green fluorescent protein in nonhuman primates transplanted with cytokine-mobilized peripheral blood CD34(+) cells.

A. Nienhuis, R. Wersto, J. Allay, 2000, Blood.

In vivo selection of retrovirally transduced hematopoietic stem cells

R. Ashmun, J. Allay, B. Sorrentino, 1998, Nature Medicine.

Genetically modified CD34+ hematopoietic stem cells contribute to turnover of brain perivascular macrophages in long-term repopulated primates.

K. Williams, C. Dunbar, R. Donahue, 2009, The American journal of pathology.

Statins protect against fulminant pneumococcal infection and cytolysin toxicity in a mouse model of sickle cell disease.

E. Tuomanen, D. Persons, C. Orihuela, 2010, The Journal of clinical investigation.

Reduction in hematopoietic stem cell numbers with in vivo drug selection can be partially abrogated by HOXB4 gene expression.

T. Lu, B. Sorrentino, D. Persons, 2003, Molecular therapy : the journal of the American Society of Gene Therapy.

erythroblastosis and polycythemia Role of erythropoietin receptor signaling in Friend virus-induced

J. Ihle, J. Rehg, Ji Zhang, 2013 .

Role of erythropoietin receptor signaling in Friend virus-induced erythroblastosis and polycythemia.

J. Ihle, J. Rehg, Ji Zhang, 2006, Blood.

Fv2 encodes a truncated form of the Stk receptor tyrosine kinase

A. Bernstein, S. Bodner, R. Paulson, 1999, Nature Genetics.

Lentiviral Transfer of γ-Globin with Fusion Gene NUP98-HOXA10HD Expands Hematopoietic Stem Cells and Ameliorates Murine β-Thalassemia.

A. Nienhuis, Yong-Dong Wang, D. Persons, 2017, Molecular therapy : the journal of the American Society of Gene Therapy.

Increased expression of glycolysis‐associated genes in oncogene‐transformed and growth‐accelerated states

D. Persons, O. Finn, N. Schek, 1989, Molecular carcinogenesis.

Transient in vivo selection of transduced peripheral blood cells using antifolate drug selection in rhesus macaques that received transplants with hematopoietic stem cells expressing dihydrofolate reductase vectors.

T. Lu, J. Allay, C. Dunbar, 2004, Blood.

Fas-antisense long noncoding RNA is differentially expressed during maturation of human erythrocytes and confers resistance to Fas-mediated cell death.

Y. Mo, D. Persons, J. Riberdy, 2016, Blood cells, molecules & diseases.

Potentially therapeutic levels of anti-sickling globin gene expression following lentivirus-mediated gene transfer in sickle cell disease bone marrow CD34+ cells.

Michael L Kaufman, D. Kohn, D. Persons, 2015, Experimental hematology.

Therapeutic levels of fetal hemoglobin in erythroid progeny of β-thalassemic CD34+ cells after lentiviral vector-mediated gene transfer.

S. Orkin, A. Nienhuis, N. Anagnou, 2011, Blood.

primary human adult erythroblasts -globin gene promoters enhances fetal hemoglobin production in γ A zinc-finger transcriptional activator designed to interact with the

U. Tschulena, A. Nienhuis, D. Persons, 2011 .

A zinc-finger transcriptional activator designed to interact with the gamma-globin gene promoters enhances fetal hemoglobin production in primary human adult erythroblasts.

C. Barbas, U. Tschulena, A. Nienhuis, 2010, Blood.

Adenovirus-mediated expresssion of the murine ecotropic receptor facilitates transduction of human hematopoietic cells with an ecotropic retroviral vector

A. Nienhuis, D. Persons, A. Mcclelland, 1999, Gene Therapy.

707. Retroviral insertion site analysis in rhesus macaques transplanted with CD34+ hematopoietic stem cells transduced with a simian immunodeficiency virus-based lentiviral vector

A. Nienhuis, J. Gray, C. Dunbar, 2004 .

Development of Gene Therapy for Hemoglobin Disorders

A. Nienhuis, B. Sorrentino, D. Persons, 2003, Annals of the New York Academy of Sciences.

High-level erythroid lineage-directed gene expression using globin gene regulatory elements after lentiviral vector-mediated gene transfer into primitive human and murine hematopoietic cells.

A. Nienhuis, D. Persons, H. Hanawa, 2002, Human gene therapy.

Progress toward safe and effective gene therapy for beta-thalassemia and sickle cell disease.

D. Persons, J. Lebensburger, 2008, Current opinion in drug discovery & development.

Increased Engraftment of Human Short Term Repopulating Hematopoietic Cells in NOD/SCID/IL2rγnull Mice by Lentiviral Expression of NUP98-HOXA10HD

D. Persons, Yoon-Sang Kim, K. Humphries, 2016, PloS one.

High-efficiency transduction and long-term gene expression with a murine stem cell retroviral vector encoding the green fluorescent protein in human marrow stromal cells.

J. Allay, D. Persons, E. Horwitz, 1999, Human gene therapy.

Transient in vivo selection of transduced peripheral blood cells using antifolate drug selection in rhesus macaques transplanted with hematopoietic stem cells expressing dihydrofolate reductase vectors

T. Lu, J. Allay, C. Dunbar, 2003 .

Globin Lentiviral Vector Insertions Can Perturb the Expression of Endogenous Genes in β-thalassemic Hematopoietic Cells.

J. Gray, Cheng Cheng, G. Neale, 2008, Molecular therapy : the journal of the American Society of Gene Therapy.

Amelioration of murine sickle cell disease by nonablative conditioning and γ-globin gene-corrected bone marrow cells

M. Weiss, D. Persons, A. Wilber, 2015, Molecular therapy. Methods & clinical development.

Optimized Lentiviral Vector Design Improves Titer and Transgene Expression of Vectors Containing the Chicken β-Globin Locus HS4 Insulator Element.

T. Shimada, D. Persons, H. Hanawa, 2009, Molecular therapy : the journal of the American Society of Gene Therapy.

A chromatin insulator blocks interactions between globin regulatory elements and cellular promoters in erythroid cells.

A. Nienhuis, B. Ryu, J. Gray, 2007, Blood cells, molecules & diseases.

Correction of Murine Sickle Cell Disease Using γ-Globin Lentiviral Vectors to Mediate High-level Expression of Fetal Hemoglobin.

J. Gray, D. Persons, T. Pestina, 2009, Molecular therapy : the journal of the American Society of Gene Therapy.

Transgenic mice with pancellular enhanced green fluorescent protein expression in primitive hematopoietic cells and all blood cell progeny

K. Boyd, P. Ney, D. Persons, 2005, Genesis.

Cell Membrane-associated heparan sulfate is a receptor for prototype foamy virus in human, monkey, and rodent cells.

D. Persons, M. Nasimuzzaman, 2012, Molecular therapy : the journal of the American Society of Gene Therapy.

MURINE PGK PROMOTER IN A LENTIVIRAL VECTOR IN CANINE LEUKOCYTE ADHESION DEFICIENCY AND IN HUMAN LAD-1 CD34+ CELLS IN NSG MICE

D. Persons, U. Choi, H. Malech, 2012 .

A pill for some anemias

D. Persons, 2007 .

Hypersusceptibility to invasive pneumococcal infection in experimental sickle cell disease involves platelet-activating factor receptor.

E. Tuomanen, D. Persons, T. Pestina, 2007, The Journal of infectious diseases.

An improved method for generating retroviral producer clones for vectors lacking a selectable marker gene.

A. Nienhuis, M. Kaleko, D. Persons, 1998, Blood cells, molecules & diseases.

Fluconazole and Candida krusei fungemia.

J. Perfect, D. Persons, J. Hathorn, 1991, The New England journal of medicine.

Therapeutic in vivo selection of thymic-derived natural T regulatory cells following non-myeloablative hematopoietic stem cell transplant for IPEX.

S. Shurtleff, D. Persons, J. Riberdy, 2011, Clinical immunology.

Tumor lysis syndrome and acute renal failure after treatment of non-small-cell lung carcinoma with combination irinotecan and cisplatin.

R. Vollmer, D. Persons, J. Garst, 1998, American journal of clinical oncology.

Amelioration of murine beta-thalassemia through drug selection of hematopoietic stem cells transduced with a lentiviral vector encoding both gamma-globin and the MGMT drug-resistance gene.

Perdeep K. Mehta, D. Persons, M. Nasimuzzaman, 2009, Blood.

Functional requirements for phenotypic correction of murine beta-thalassemia: implications for human gene therapy.

A. Nienhuis, D. Bodine, D. Persons, 2001, Blood.

Solving the problem of γ-retroviral vectors containing long terminal repeats.

D. Persons, C. Baum, 2011, Molecular therapy : the journal of the American Society of Gene Therapy.

Distinct Genomic Integration of MLV and SIV Vectors in Primate Hematopoietic Stem and Progenitor Cells

Christof von Kalle, Manfred Schmidt, Peiman Hematti, 2004, PLoS biology.

Efficient gene transfer into rhesus repopulating hematopoietic stem cells using a simian immunodeficiency virus-based lentiviral vector system.

K. Keyvanfar, A. Nienhuis, J. Gray, 2004, Blood.

Development of gene therapy for thalassemia.

A. Nienhuis, D. Persons, 2012, Cold Spring Harbor perspectives in medicine.

High-efficiency transduction of rhesus hematopoietic repopulating cells by a modified HIV1-based lentiviral vector.

T. Wolfsberg, A. Nguyen, J. Tisdale, 2012, Molecular therapy : the journal of the American Society of Gene Therapy.

Gene therapy for canine leukocyte adhesion deficiency with lentiviral vectors using the murine stem cell virus and human phosphoglycerate kinase promoters.

D. Persons, L. Tuschong, D. Hickstein, 2011, Human gene therapy.

Gene therapy: Targeting β-thalassaemia

D. Persons, 2010, Nature.

Sustained high-level polyclonal hematopoietic marking and transgene expression 4 years after autologous transplantation of rhesus macaques with SIV lentiviral vector-transduced CD34+ cells.

Jean A. Roayaei, T. Wolfsberg, G. Renaud, 2009, Blood.

Optimized lentiviral vector design improves titer and transgene expression of vectors containing the chicken beta-globin locus HS4 insulator element.

T. Shimada, D. Persons, H. Hanawa, 2009, Molecular therapy : the journal of the American Society of Gene Therapy.

Hematopoietic stem cell gene transfer for the treatment of hemoglobin disorders.

D. Persons, Derek A Persons, 2009, Hematology. American Society of Hematology. Education Program.

Murine Leukemia Virus as a Vector to Transfer Genes into Blood Stem Cells : Success in Two Immunodeficiency Disorders

D. Persons, 2009 .

An experimental system for the evaluation of retroviral vector design to diminish the risk for proto-oncogene activation.

A. Nienhuis, B. Ryu, J. Gray, 2008, Blood.

Haemoglobin Disorders: Gene Therapy

A. Nienhuis, D. Persons, 2006 .

Altered growth regulation and enhanced tumorigenicity of NIH 3T3 fibroblasts transfected with protein kinase C-I cDNA

W. Wilkison, R. Bell, D. Persons, 1988, Cell.

Functional amelioration of murine galactosialidosis by genetically modified bone marrow hematopoietic progenitor cells.

Richard J Smeyne, A. Nienhuis, J. Cunningham, 2002, Blood.

The degree of phenotypic correction of murine beta -thalassemia intermedia following lentiviral-mediated transfer of a human gamma-globin gene is influenced by chromosomal position effects and vector copy number.

A. Nienhuis, D. Persons, E. Allay, 2003, Blood.

Transcriptional regulation of fetal to adult hemoglobin switching: new therapeutic opportunities.

A. Nienhuis, D. Persons, A. Wilber, 2011, Blood.

therapeutic opportunities Transcriptional regulation of fetal to adult hemoglobin switching: new

A. Nienhuis, D. Persons, A. Wilber, 2012 .

Extended β-globin locus control region elements promote consistent therapeutic expression of a γ-globin lentiviral vector in murine β-thalassemia

D. Srivastava, A. Nienhuis, D. Persons, 2004 .

Extended beta-globin locus control region elements promote consistent therapeutic expression of a gamma-globin lentiviral vector in murine beta-thalassemia.

D. Srivastava, A. Nienhuis, D. Persons, 2004, Blood.

Gene therapy for the hemoglobin disorders.

A. Nienhuis, D. Persons, 2003, Current hematology reports.

Targeting gene-modified hematopoietic cells to the central nervous system: Use of green fluorescent protein uncovers microglial engraftment

M. Frotscher, U. Dirnagl, I. Bechmann, 2001, Nature Medicine.

Nfix is a novel regulator of murine hematopoietic stem and progenitor cell survival.

S. McKinney-Freeman, D. Finkelstein, J. Gray, 2013, Blood.

Low-level GATA2 overexpression promotes myeloid progenitor self-renewal and blocks lymphoid differentiation in mice.

G. Neale, D. Persons, Satish K. Nandakumar, 2015, Experimental hematology.

Comparison of various envelope proteins for their ability to pseudotype lentiviral vectors and transduce primitive hematopoietic cells from human blood.

Jody A. Vandergriff, A. Nienhuis, D. Persons, 2002, Molecular therapy : the journal of the American Society of Gene Therapy.

Enforced expression of the GATA-2 transcription factor blocks normal hematopoiesis.

D Orlic, S. Jane, A. Nienhuis, 1999, Blood.

Transduction of human primitive repopulating hematopoietic cells with lentiviral vectors pseudotyped with various envelope proteins.

A. Nienhuis, J. Gray, D. Persons, 2010, Molecular therapy : the journal of the American Society of Gene Therapy.

Gene therapy for the hemoglobin disorders: past, present, and future.

A. Nienhuis, D. Persons, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Hematopoietic cells and osteoblasts are derived from a common marrow progenitor after bone marrow transplantation.

D. Persons, E. Horwitz, T. Hofmann, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Neogenesis of cerebellar Purkinje neurons from gene-marked bone marrow cells in vivo

U. Dirnagl, G. Kreutzberg, G. Kempermann, 2001, The Journal of cell biology.

The challenge of obtaining therapeutic levels of genetically modified hematopoietic stem cells in β‐thalassemia patients

D. Persons, 2010, Annals of the New York Academy of Sciences.

Correction of murine sickle cell disease using gamma-globin lentiviral vectors to mediate high-level expression of fetal hemoglobin.

J. Gray, D. Persons, T. Pestina, 2009, Molecular therapy : the journal of the American Society of Gene Therapy.

Hydroxyurea therapy of a murine model of sickle cell anemia inhibits the progression of pneumococcal disease by down-modulating E-selectin.

Stanislav S Zakharenko, R. Ware, E. Tuomanen, 2012, Blood.

Successful treatment of murine beta-thalassemia using in vivo selection of genetically modified, drug-resistant hematopoietic stem cells.

A. Nienhuis, T. Brent, B. Sorrentino, 2003, Blood.

Genomic analyses of pneumococci from children with sickle cell disease expose host-specific bacterial adaptations and deficits in current interventions.

A. Camilli, E. Tuomanen, D. Persons, 2014, Cell host & microbe.

Lentiviral vector gene therapy: effective and safe?

D. Persons, 2010, Molecular therapy : the journal of the American Society of Gene Therapy.

Analysis of alpha hemoglobin stabilizing protein overexpression in murine β‐thalassemia

Xiaomei Wang, S. Rivella, Xiaomei Wang, 2010, American journal of hematology.

Gene therapy for the hemoglobin disorders.

J. Tisdale, D. Persons, 2004, Seminars in hematology.

Protein kinase C gamma expression mimics phorbol ester-induced transcriptional activation of a murine VL30 enhancer element.

Michael C. Ostrowski, D. Persons, O. Finn, 1991, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

Regulation of Primitive Hematopoietic Cell Growth and Differentiation by the Gata-2 Transcription Factor.

D. Persons, S. Throm, 2004 .

Globin Lentiviral Vector Insertions Can Perturb the Expression of Endogenous Genes in β-thalassemic Hematopoietic Cells.

J. Gray, Cheng Cheng, G. Neale, 2008, Molecular therapy : the journal of the American Society of Gene Therapy.

Update on gene therapy for hemoglobin disorders.

D. Persons, 2003, Current opinion in molecular therapeutics.

Lentiviral vector gene therapy: effective and safe?

D. Persons, 2010, Molecular therapy : the journal of the American Society of Gene Therapy.

Amelioration of murine beta-thalassemia through drug selection of hematopoietic stem cells transduced with a lentiviral vector encoding both gamma-globin and the MGMT drug-resistance gene.

Perdeep K. Mehta, D. Persons, M. Nasimuzzaman, 2009, Blood.