H. Worman

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Nuclear Membrane Dynamics and Reassembly in Living Cells: Targeting of an Inner Nuclear Membrane Protein in Interphase and Mitosis

Howard J. Worman, Jan Ellenberg, Eric D. Siggia, 1997, The Journal of cell biology.

Targeting and Retention of Proteins in the Inner and Pore Membranes of the Nuclear Envelope

Wei Wu, H. Worman, Cecilia Östlund, 2002 .

The amino-terminal domain of the lamin B receptor is a nuclear envelope targeting signal

H. Worman, B. Soullam, Bruno Soullam, 1993, The Journal of cell biology.

Pathogenic mutations in genes encoding nuclear envelope proteins and defective nucleocytoplasmic connections

G. Gundersen, H. Worman, Cecilia Östlund, 2019, Experimental biology and medicine.

Cellular stress induces Bax-regulated nuclear bubble budding and rupture followed by nuclear protein release

C. Borner, H. Worman, L. Lindenboim, 2014, Nucleus.

Expression and functional analysis of three isoforms of human heterochromatin-associated protein HP1 in Drosophila

H. Worman, J. C. Eissenberg, Jiyan Ma, 2001, Chromosoma.

Transcriptional repression of euchromatic genes by Drosophila heterochromatin protein 1 and histone modifiers

H. Worman, J. C. Eissenberg, K. Hwang, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Molecular biology of liver disorders:the hepatitis C virus and molecular targets for drug development.

H. Worman, F. Lin, 2000, World journal of gastroenterology.

"Laminopathies": a wide spectrum of human diseases.

H. Worman, G. Bonne, 2007, Experimental cell research.

Nuclear lamins and laminopathies

H. Worman, 2012, The Journal of pathology.

Diseases of the nuclear envelope.

H. Worman, C. Ostlund, Yuexia Wang, 2010, Cold Spring Harbor perspectives in biology.

Both lamin A and lamin C mutations cause lamina instability as well as loss of internal nuclear lamin organization.

J. Broers, H. Kuijpers, F. Ramaekers, 2005, Experimental cell research.

Structural organization of the human gene (LMNB1) encoding nuclear lamin B1.

H. Worman, F. Lin, 1995, Genomics.

Contextual Automated 3D Analysis of Subcellular Organelles Adapted to High-Content Screening

A. Genovesio, W. Dauer, R. Grailhe, 2010, Journal of biomolecular screening.

contextual Automated 3 d Analysis of Subcellular organelles Adapted to High-content Screening

A. Genovesio, H. Worman, T. Dorval, 2010 .

ERK1/2 directly acts on CTGF/CCN2 expression to mediate myocardial fibrosis in cardiomyopathy caused by mutations in the lamin A/C gene.

S. Homma, F. Sera, Wei Wu, 2016, Human molecular genetics.

Extracellular matrix remodeling and transforming growth factor-β signaling abnormalities induced by lamin A/C variants that cause lipodystrophy[S]

Wei Wu, C. Vigouroux, J. Capeau, 2016, Journal of Lipid Research.

New PPARG mutation leads to lipodystrophy and loss of protein function that is partially restored by a synthetic ligand

H. Worman, H. Schmidt, A. Lüdtke, 2007, Journal of Medical Genetics.

Structural organization of the human gene encoding nuclear lamin A and nuclear lamin C.

H. Worman, F. Lin, 1993, The Journal of biological chemistry.

The lamin B receptor of the nuclear envelope inner membrane: a polytopic protein with eight potential transmembrane domains

G. Blobel, H. Worman, C. D. Evans, 1990, The Journal of cell biology.

Protein structural and mechanistic basis of progeroid laminopathies

S. Zinn-Justin, H. Worman, A. Marcelot, 2020, The FEBS journal.

A lamin A/C variant causing striated muscle disease provides insights into filament organization

O. Medalia, M. Eibauer, Wei Wu, 2020, Journal of Cell Science.

Human Diseases Related to Nuclear Envelope Proteins

H. Worman, 2016 .

Blocking farnesylation of the prelamin A variant in Hutchinson-Gilford progeria syndrome alters the distribution of A-type lamins

G. Gundersen, H. Worman, Yuexia Wang, 2012, Nucleus.

Blocking protein farnesylation improves nuclear shape abnormalities in keratinocytes of mice expressing the prelamin A variant in Hutchinson-Gilford progeria syndrome

H. Worman, Cecilia Östlund, Yuexia Wang, 2010, Nucleus.

Epidermal expression of the truncated prelamin A causing Hutchinson-Gilford progeria syndrome: effects on keratinocytes, hair and skin.

C. Stewart, H. Worman, Yuexia Wang, 2008, Human molecular genetics.

Inhibition of extracellular signal-regulated kinase 1/2 signaling has beneficial effects on skeletal muscle in a mouse model of Emery-Dreifuss muscular dystrophy caused by lamin A/C gene mutation

Wei Wu, H. Worman, Y. J. Kim, 2013, Skeletal Muscle.

Perturbation of nuclear lamin A causes cell death in chondrocytes.

S. Abramson, H. Worman, M. Attur, 2012, Arthritis and rheumatism.

TAN lines

G. Gundersen, H. Worman, G. Luxton, 2011 .

Risk factors and comorbidities in primary biliary cirrhosis: A controlled interview‐based study of 1032 patients

M. Kaplan, K. Lindor, E. Gold, 2005, Hepatology.

The nuclear envelope as a signaling node in development and disease.

Howard J Worman, William T Dauer, W. Dauer, 2009, Developmental cell.

Cell signaling abnormalities in cardiomyopathy caused by lamin A/C gene mutations.

H. Worman, 2017, Biochemical Society transactions.

Lamina-associated polypeptide 1 is dispensable for embryonic myogenesis but required for postnatal skeletal muscle growth

Wei Wu, W. Dauer, H. Worman, 2016, Human molecular genetics.

Lamina-associated polypeptide 1: protein interactions and tissue-selective functions.

W. Dauer, H. Worman, Ji-Yeon Shin, 2014, Seminars in cell & developmental biology.

Depletion of lamina-associated polypeptide 1 from cardiomyocytes causes cardiac dysfunction in mice

S. Homma, F. Sera, W. Dauer, 2014, Nucleus.

Nucleocytoplasmic connections and deafness.

N. Segil, H. Worman, 2013, The Journal of clinical investigation.

Inner nuclear membrane proteins: impact on human disease

H. Worman, I. Méndez-López, 2012, Chromosoma.

NMR Spectroscopy as a Tool to Provide Mechanistic Clues About Protein Function and Disease Pathogenesis

S. Zinn-Justin, H. Worman, Benjamin M. R. Bourgeois, 2012 .

LMNA cardiomyopathy: cell biology and genetics meet clinical medicine

Jonathan T. Lu, H. Worman, P. Nagy, 2011, Disease Models & Mechanisms.

Signaling defects and the nuclear envelope in progeria.

H. Worman, A. Muchir, 2010, Developmental cell.

Pathology and nuclear abnormalities in hearts of transgenic mice expressing M371K lamin A encoded by an LMNA mutation causing Emery-Dreifuss muscular dystrophy.

H. Worman, A. Herron, Yuexia Wang, 2006, Human molecular genetics.

Nuclear lamin A inhibits adipocyte differentiation: implications for Dunnigan-type familial partial lipodystrophy.

C. Stewart, H. Worman, R. L. Boguslavsky, 2006, Human molecular genetics.

Dynamics and molecular interactions of linker of nucleoskeleton and cytoskeleton (LINC) complex proteins

G. Gundersen, H. Worman, Cecilia Östlund, 2009, Journal of Cell Science.

Loss of a DNA binding site within the tail of prelamin A contributes to altered heterochromatin anchorage by progerin

E. Delbarre, B. Buendia, H. Worman, 2010, FEBS letters.

Abnormal p38α mitogen-activated protein kinase signaling in dilated cardiomyopathy caused by lamin A/C gene mutation.

S. Homma, Wei Wu, H. Worman, 2012, Human molecular genetics.

Protein-protein interactions between human nuclear lamins expressed in yeast.

H. Worman, Q. Ye, 1995, Experimental cell research.

Mitogen-activated protein kinase kinase 1/2 inhibition and angiotensin II converting inhibition in mice with cardiomyopathy caused by lamin A/C gene mutation.

S. Homma, F. Sera, Wei Wu, 2014, Biochemical and biophysical research communications.

Decreased WNT/&bgr;-catenin signalling contributes to the pathogenesis of dilated cardiomyopathy caused by mutations in the lamin a/C gene

S. Homma, F. Sera, H. Worman, 2017, Human molecular genetics.

Epithelial cell specificity and apotope recognition by serum autoantibodies in primary biliary cirrhosis

G. Gores, R. Coppel, Xiao-Song He, 2011, Hepatology.

Nuclear protein antigens in primary biliary cirrhosis

H. Worman, J. Courvalin, B. Terjung, 2000 .

Whole exome sequencing in the diagnosis of liver diseases

A. Gharavi, M. Marasà, E. Cocchi, 2022, medRxiv.

The nuclear envelope and human disease.

Howard J Worman, H. Worman, A. Muchir, 2004, Physiology.

Pharmacological inhibition of c-Jun N-terminal kinase signaling prevents cardiomyopathy caused by mutation in LMNA gene.

Wei Wu, H. Worman, G. Bonne, 2010, Biochimica et biophysica acta.

Emery-Dreifuss muscular dystrophy

H. Worman, A. Muchir, Howard J. Worman, 2007, Current neurology and neuroscience reports.

Activation of MAPK in hearts of EMD null mice: similarities between mouse models of X-linked and autosomal dominant Emery Dreifuss muscular dystrophy.

P. Pavlidis, Y. Hayashi, H. Worman, 2007, Human molecular genetics.

Proteasome-mediated degradation of integral inner nuclear membrane protein emerin in fibroblasts lacking A-type lamins.

H. Worman, B. V. van Engelen, G. Bonne, 2006, Biochemical and biophysical research communications.

Characterization of the human gene encoding LBR, an integral protein of the nuclear envelope inner membrane.

H. Worman, F. Lin, E. Schuler, 1994, The Journal of biological chemistry.

Nuclear envelope alterations in fibroblasts from patients with muscular dystrophy, cardiomyopathy, and partial lipodystrophy carrying lamin A/C gene mutations

I. Desguerre, T. Arimura, H. Worman, 2004, Muscle & nerve.

Diagnosis and treatment of chronic hepatitis C in incarcerated patients.

H. Worman, 2008, The virtual mentor : VM.

Molecular biological methods in diagnosis and treatment of liver diseases.

H. Worman, 1997, Clinical chemistry.

Components of the nuclear envelope and their role in human disease.

H. Worman, 2005, Novartis Foundation symposium.

Nuclear envelope protein autoantigens in primary biliary cirrhosis

H. Worman, 2007, Hepatology research : the official journal of the Japan Society of Hepatology.

Inner nuclear membrane and signal transduction

H. Worman, 2005, Journal of cellular biochemistry.

Lamin-associated proteins.

H. Worman, C. Ostlund, 2004, Methods in cell biology.

Risk factors for primary biliary cirrhosis in a cohort of patients from the United States

E. Gold, M. Gershwin, H. Worman, 2001, Hepatology.

Muscular Dystrophy-Associated SUN1 and SUN2 Variants Disrupt Nuclear-Cytoskeletal Connections and Myonuclear Organization

G. Gundersen, H. Worman, G. Lattanzi, 2014, PLoS genetics.

JCB_201409047 1..12

G. Gundersen, H. Worman, Wakam Chang, 2014 .

Peroxisome proliferator-activated receptor-gamma C190S mutation causes partial lipodystrophy.

Wei Wu, H. Worman, H. Schmidt, 2007, The Journal of clinical endocrinology and metabolism.

Hepatic Steatosis in Dunnigan-Type Familial Partial Lipodystrophy

M. Taupitz, J. Genschel, H. Worman, 2005, The American Journal of Gastroenterology.

Reactivation of autophagy ameliorates LMNA cardiomyopathy

H. Worman, Jason C. Choi, 2013, Autophagy.

Autoantibodies from patients with primary biliary cirrhosis recognize a restricted region within the cytoplasmic tail of nuclear pore membrane glycoprotein Gp210

H. Worman, R. E. Nickowitz, Howard J. Worman, 1993, The Journal of experimental medicine.

Vibration-controlled Transient Elastography for Assessment of Liver Fibrosis at a USA Academic Medical Center

H. Worman, J. Lefkowitch, M. Shen, 2021, Journal of clinical and translational hepatology.

Treatment with selumetinib preserves cardiac function and improves survival in cardiomyopathy caused by mutation in the lamin A/C gene.

S. Homma, Wei Wu, H. Worman, 2012, Cardiovascular research.

Effect of pathogenic mis-sense mutations in lamin A on its interaction with emerin in vivo

C. Stewart, H. Worman, I. Holt, 2003, Journal of Cell Science.

82nd ENMC international workshop, 5th international Emery–Dreifuss muscular dystrophy (EDMD) workshop, 1st Workshop of the MYO-CLUSTER project EUROMEN (European muscle envelope nucleopathies), 15–16 September 2000, Naarden, The Netherlands

F. Muntoni, D. Duboc, H. Worman, 2002, Neuromuscular Disorders.

Molecular mimicry of mitochondrial and nuclear autoantigens in primary biliary cirrhosis.

S. Matsushita, M. Harada, A. Tanaka, 2003, Gastroenterology.

Cofilin-1 phosphorylation catalyzed by ERK1/2 alters cardiac actin dynamics in dilated cardiomyopathy caused by lamin A/C gene mutation

W. H. Goldmann, W. Goldmann, P. Knaus, 2018, Human molecular genetics.

Cardiomyocyte-Specific Expression of Lamin A Improves Cardiac Function in Lmna −/− Mice

Richard L. Frock, B. Kennedy, P. Rabinovitch, 2012, PloS one.

Emery-Dreifuss muscular dystrophy: focal point nuclear envelope.

H. Worman, A. Muchir, 2019, Current opinion in neurology.

Autoantibodies from patients with primary biliary cirrhosis recognize a region within the nucleoplasmic domain of inner nuclear membrane protein LBR

H. Worman, J. Courvalin, F. Lin, 1996, Hepatology.

Permanently Farnesylated Prelamin A, Progeria, and Atherosclerosis

H. Worman, S. Michaelis, 2018, Circulation.

Prelamin A prenylation and the treatment of progeria1

H. Worman, 2010, Journal of Lipid Research.

Cellular intermediate filament networks and their derangement in alcoholic hepatitis.

H. Worman, 1990, Alcoholism, clinical and experimental research.

Expression of nuclear lamins in human tissues and cancer cell lines and transcription from the promoters of the lamin A/C and B1 genes.

H. Worman, F. Lin, Feng Lin, 1997, Experimental cell research.

Comparative studies of antimitochondrial autoantibodies in sera and bile in primary biliary cirrhosis

J. Neuberger, R. Coppel, J. Lake, 1997, Hepatology.

The lipid fluidity of rat colonic brush-border membrane vesicles modulates Na+-H+ exchange and osmotic water permeability.

H. Worman, P. Dudeja, T. Brasitus, 1986, Biochimica et biophysica acta.

Long‐term treatment experience in a subject with Dunnigan‐type familial partial lipodystrophy: efficacy of rosiglitazone

J. Genschel, H. Worman, H. Mehnert, 2005, Diabetic medicine : a journal of the British Diabetic Association.

Developmental changes in the amount and functional state of UDP-glucuronosyltransferase.

A. Dannenberg, H. Worman, S. Scarlata, 1992, Biochimica et biophysica acta.

Chromosomal assignment of human nuclear envelope protein genes LMNA, LMNB1, and LBR by fluorescence in situ hybridization.

J. Mcneil, J. Lawrence, H. Worman, 1996, Genomics.

Expression of lamin A mutated in the carboxyl-terminal tail generates an aberrant nuclear phenotype similar to that observed in cells from patients with Dunnigan-type partial lipodystrophy and Emery-Dreifuss muscular dystrophy.

C. Vigouroux, B. Buendia, J. Capeau, 2003, Experimental cell research.

PBC screen: an IgG/IgA dual isotype ELISA detecting multiple mitochondrial and nuclear autoantibodies specific for primary biliary cirrhosis.

D. Vergani, E. Tan, A. Czaja, 2010, Journal of autoimmunity.

Nuclear envelope protein autoantibodies in primary biliary cirrhosis.

H. Worman, J. Courvalin, 1997, Seminars in liver disease.

Autoantibodies against integral membrane proteins of the nuclear envelope in patients with primary biliary cirrhosis.

R. Wozniak, F. Schaffner, H. Worman, 1994, Gastroenterology.

Detection of Gp210 autoantibodies in primary biliary cirrhosis using a recombinant protein containing the predominant autoepitope

H. Worman, F. Tartakovsky, Flora Tartakovsky, 1995, Hepatology.

Identification and characterization of autoantibodies against the nuclear envelope lamin B receptor from patients with primary biliary cirrhosis

G. Blobel, K. Lassoued, H. Worman, 1990, The Journal of experimental medicine.

The antinuclear autoantibodies Sp100 and gp210 persist after orthotopic liver transplantation in patients with primary biliary cirrhosis.

M. Manns, H. Will, M. Gershwin, 1998, Journal of hepatology.

Autoantibodies against nuclear envelope proteins in liver disease

H. Worman, J. Courvalin, Jean‐Claude Courvalin, 1991, Hepatology.

Differentiation of antineutrophil nuclear antibodies in inflammatory bowel and autoimmune liver diseases from antineutrophil cytoplasmic antibodies (p‐ANCA) using immunofluorescence microscopy

T. Sauerbruch, U. Spengler, V. Herzog, 2001, Clinical and experimental immunology.

Autoantibodies in human chronic graft-versus-host disease after hematopoietic cell transplantation.

M. Manns, K. Tsuneyama, A. Ahmed, 1999, Clinical immunology.

Lamin A/C Depletion Enhances DNA Damage-Induced Stalled Replication Fork Arrest

Benjamin P. C. Chen, M. Löbrich, T. Pandita, 2013, Molecular and Cellular Biology.

Hepatocytes Deficient in Nuclear Envelope Protein Lamina-associated Polypeptide 1 are an Ideal Mammalian System to Study Intranuclear Lipid Droplets

W. Dauer, H. Worman, H. Ginsberg, 2022, bioRxiv.

Probable Bexarotene Hepatotoxicity Associated With Transient Serum Antimitochondrial Antibodies

H. Worman, 2012 .

Relationship between lipid fluidity and water permeability of bovine tracheal epithelial cell apical membranes.

H. Fozzard, H. Worman, P. Dudeja, 1986, Biochemistry.

Inner nuclear membrane proteins: impact on human disease

H. Worman, I. Méndez-López, 2012, Chromosoma.

Nuclear envelope, nuclear lamina, and inherited disease.

H. Worman, J. Courvalin, 2005, International review of cytology.

Molecular biology and the diagnosis and treatment of liver diseases.

H. Worman, N. Mamiya, Lin Feng, 1998, World journal of gastroenterology.

Hepatitis B virus reactivation after kidney transplantation and new onset lymphoma.

A. Larghi, H. Worman, D. Leffler, 2003, Journal of clinical gastroenterology.

Human Heterochromatin Protein 1 Isoforms HP1Hsα and HP1Hsβ Interfere with hTERT-Telomere Interactions and Correlate with Changes in Cell Growth and Response to Ionizing Radiation

T. Pandita, R. Wellinger, Arun Gupta, 2003, Molecular and Cellular Biology.

Structural analysis of emerin, an inner nuclear membrane protein mutated in X‐linked Emery–Dreifuss muscular dystrophy

S. Zinn-Justin, B. Gilquin, I. Callebaut, 2001, FEBS letters.

MAN1, an Inner Nuclear Membrane Protein That Shares the LEM Domain with Lamina-associated Polypeptide 2 and Emerin*

M. Paulin-Levasseur, M. McBurney, D. Blake, 2000, The Journal of Biological Chemistry.

Intracellular trafficking of emerin, the Emery-Dreifuss muscular dystrophy protein.

J. Lippincott-Schwartz, J. Ellenberg, E. Hallberg, 1999, Journal of cell science.

Molecular biological xxxmethods in diagnosis and treatment of liver diseases

H. Worman, 1997 .

Decreased and aberrant nuclear lamin expression in gastrointestinal tract neoplasms

S. Moss, H. Worman, P. Holt, 1999, Gut.

Accessorizing and anchoring the LINC complex for multifunctionality

G. Gundersen, H. Worman, Wakam Chang, 2015, The Journal of cell biology.

Peroxisome Proliferator-Activated Receptor-γ C190S Mutation Causes Partial Lipodystrophy

Wei Wu, S. Zinn-Justin, H. Worman, 2007 .

Neuronal Differentiation of NT2/D1 Teratocarcinoma Cells Is Accompanied by a Loss of Lamin A/C Expression and an Increase in Lamin B1 Expression

J. Holy, H. Worman, Tanya Pierce, 1999, Experimental Neurology.

Depletion of extracellular signal-regulated kinase 1 in mice with cardiomyopathy caused by lamin A/C gene mutation partially prevents pathology before isoenzyme activation.

S. Homma, Wei Wu, H. Worman, 2014, Human molecular genetics.

TorsinA controls TAN line assembly and the retrograde flow of dorsal perinuclear actin cables during rearward nuclear movement

Nathan J. Harris, W. Dauer, G. Gundersen, 2017, The Journal of cell biology.

Interaction between an Integral Protein of the Nuclear Envelope Inner Membrane and Human Chromodomain Proteins Homologous to Drosophila HP1*

H. Worman, Q. Ye, 1996, The Journal of Biological Chemistry.

Nuclear Positioning

G. Gundersen, H. Worman, 2013, Cell.

Structural characterization of the LEM motif common to three human inner nuclear membrane proteins.

N. Wolff, S. Zinn-Justin, B. Gilquin, 2001, Structure.

Nuclear envelope proteins and neuromuscular diseases

H. Worman, Cecilia Östlund, 2003, Muscle & nerve.

Postnatal Development of Mice with Combined Genetic Depletions of Lamin A/C, Emerin and Lamina-associated Polypeptide 1.

S. Homma, C. Stewart, H. Worman, 2019, Human molecular genetics.

Inner nuclear membrane proteins: functions and targeting

H. Worman, L. Holmér, 2001, Cellular and Molecular Life Sciences CMLS.

Signals and structural features involved in integral membrane protein targeting to the inner nuclear membrane

H. Worman, B. Soullam, Bruno Soullam, 1995, The Journal of cell biology.

Primary structure analysis and lamin B and DNA binding of human LBR, an integral protein of the nuclear envelope inner membrane.

H. Worman, Q. Ye, Howard J. Worman, 1994, The Journal of biological chemistry.

Portal vein thrombosis associated with Fusobacterium nucleatum septicemia in a patient with ulcerative colitis.

A. Larghi, E. Verna, H. Worman, 2004, Journal of clinical gastroenterology.

Next-Generation Sequencing and Mutational Analysis: Implications for Genes Encoding LINC Complex Proteins.

Peter L Nagy, Howard J Worman, H. Worman, 2018, Methods in molecular biology.

Dermal fibroblasts in Hutchinson-Gilford progeria syndrome with the lamin A G608G mutation have dysmorphic nuclei and are hypersensitive to heat stress

Howard J Worman, H. Worman, M. Paradisi, 2005, BMC Cell Biology.

Domain-specific Interactions of Human HP1-type Chromodomain Proteins and Inner Nuclear Membrane Protein LBR*

I. Callebaut, H. Worman, J. Courvalin, 1997, The Journal of Biological Chemistry.

Elevated dual specificity protein phosphatase 4 in cardiomyopathy caused by lamin A/C gene mutation is primarily ERK1/2-dependent and its depletion improves cardiac function and survival

S. Homma, F. Sera, Wei Wu, 2018, Human molecular genetics.

A lamin B receptor in the nuclear envelope.

G. Blobel, H. Worman, J. Yuan, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Hepatitis C Virus Core Protein Binds to a DEAD Box RNA Helicase*

H. Worman, N. Mamiya, 1999, The Journal of Biological Chemistry.

Apoptotic stress induces Bax-dependent, caspase-independent redistribution of LINC complex nesprins

C. Borner, D. Hodzic, G. Gundersen, 2020, Cell Death Discovery.

Localization and phosphorylation of HP1 proteins during the cell cycle in mammalian cells

Y. Allory, B. Buendia, H. Worman, 1999, Chromosoma.

Activation of MAPK pathways links LMNA mutations to cardiomyopathy in Emery-Dreifuss muscular dystrophy.

Paul Pavlidis, Howard J Worman, Gisèle Bonne, 2007, The Journal of clinical investigation.

The carboxyl-terminal region common to lamins A and C contains a DNA binding domain.

S. Zinn-Justin, H. Worman, J. Courvalin, 2003, Biochemistry.

Properties of lamin A mutants found in Emery-Dreifuss muscular dystrophy, cardiomyopathy and Dunnigan-type partial lipodystrophy.

H. Worman, K. Schwartz, G. Bonne, 2001, Journal of cell science.

The Ig-like structure of the C-terminal domain of lamin A/C, mutated in muscular dystrophies, cardiomyopathy, and partial lipodystrophy.

S. Zinn-Justin, B. Gilquin, J. Mornon, 2002, Structure.

The lamin B receptor of the inner nuclear membrane undergoes mitosis-specific phosphorylation and is a substrate for p34cdc2-type protein kinase.

G. Blobel, N. Segil, G. Blobel, 1992, The Journal of biological chemistry.

The R439C mutation in LMNA causes lamin oligomerization and susceptibility to oxidative stress

S. Zinn-Justin, J. Broers, P. Steijlen, 2009, Journal of cellular and molecular medicine.

Dependence of diffusional mobility of integral inner nuclear membrane proteins on A-type lamins.

C. Stewart, H. Worman, C. Ostlund, 2006, Biochemistry.

MAN1, an integral protein of the inner nuclear membrane, binds Smad2 and Smad3 and antagonizes transforming growth factor-beta signaling.

Wei Wu, H. Worman, F. Lin, 2005, Human molecular genetics.

membrane, binds Smad2 and Smad3 and antagonizes transforming growth factor-b signaling

Wei Wu, H. Worman, F. Lin, 2005 .

Lamina-associated polypeptide-1 interacts with the muscular dystrophy protein emerin and is essential for skeletal muscle maintenance.

P. Schulze, W. Dauer, H. Worman, 2013, Developmental cell.

Nuclear lamin-binding proteins.

H. Worman, Q. Ye, R. M. Barton, 1998, Sub-cellular biochemistry.

Altered protein dynamics of disease-associated lamin A mutants

W. Bickmore, N. Gilbert, H. Worman, 2004, BMC Cell Biology.

The Inner Nuclear Membrane

H. Worman, J. Courvalin, 2000, The Journal of Membrane Biology.

Cell cycle-dependent phosphorylation of nucleoporins and nuclear pore membrane protein Gp210.

R. Wozniak, H. Worman, J. Courvalin, 1996, Biochemistry.

Here come the SUNs: a nucleocytoskeletal missing link.

G. Gundersen, H. Worman, 2006, Trends in cell biology.

Nuclear membrane diversity: underlying tissue-specific pathologies in disease?

E. C. Schirmer, H. Worman, 2015, Current opinion in cell biology.

Nuclear lamina heterogeneity in mammalian cells. Differential expression of the major lamins and variations in lamin B phosphorylation.

H. Worman, I. Lazaridis, S. Georgatos, 1988, The Journal of biological chemistry.

The nuclear lamina and inherited disease.

Howard J Worman, H. Worman, J. Courvalin, 2002, Trends in cell biology.

The expression of nuclear lamins in human liver: an immunohistochemical study.

S. Thung, H. Worman, P. Hytiroglou, 1993, Human pathology.

TAN lines: a novel nuclear envelope structure involved in nuclear positioning.

G. Gundersen, H. Worman, G. Luxton, 2011, Nucleus.

"Atypical p-ANCA" in IBD and hepatobiliary disorders react with a 50-kilodalton nuclear envelope protein of neutrophils and myeloid cell lines.

T. Sauerbruch, U. Spengler, H. Worman, 2000, Gastroenterology.

A-type lamins: Guardians of the soma?

H. Worman, C. Hutchison, 2004, Nature Cell Biology.

Abolishing the prelamin A ZMPSTE24 cleavage site leads to progeroid phenotypes with near-normal longevity in mice

Eric D. Spear, Wei Wu, W. Hsu, 2021, bioRxiv.

The Nuclear Envelope: An Intriguing Focal Point for Neurogenetic Disease

W. Dauer, H. Worman, 2014, Neurotherapeutics.

Laminopathies and the long strange trip from basic cell biology to therapy.

S. Young, H. Worman, L. Fong, 2009, The Journal of clinical investigation.

Biliary apotopes and anti-mitochondrial antibodies activate innate immune responses in primary biliary cirrhosis.

G. Gores, R. Coppel, M. Gershwin, 2010, Hepatology.

The nuclear envelope: target and mediator of the apoptotic process

H. Worman, L. Lindenboim, R. Stein, 2020, Cell Death Discovery.

Imbalanced nucleocytoskeletal connections create common polarity defects in progeria and physiological aging

G. Gundersen, H. Worman, Wakam Chang, 2018, Proceedings of the National Academy of Sciences.

How do mutations in lamins A and C cause disease?

H. Worman, J. Courvalin, 2004, The Journal of clinical investigation.

to Ionizing Radiation Response with Changes in Cell Growth and Correlate hTERT-Telomere Interactions and Interfere with β Hs and HP1 α Hs HP1Heterochromatin Protein 1 Isoforms

R. Wellinger, R. Pandita, S. Dhar, 2014 .

ERK1/2 Phosphorylation of FHOD Connects Signaling and Nuclear Positioning Alternations in Cardiac Laminopathy.

Wei Wu, G. Gundersen, H. Worman, 2019, Developmental cell.

Anti-neutrophil antibodies in primary sclerosing cholangitis.

H. Worman, B. Terjung, 2001, Best practice & research. Clinical gastroenterology.

Lamin A/C Depletion Enhances DNA Damage-Induced Stalled Replication Fork Arrest

Benjamin P. C. Chen, M. Löbrich, T. Pandita, 2013, Molecular and Cellular Biology.

Structural analysis of the Smad2-MAN1 interaction that regulates transforming growth factor-β signaling at the inner nuclear membrane.

Wei Wu, S. Zinn-Justin, B. Gilquin, 2010, Biochemistry.

Epitope‐specific anti‐nuclear antibodies are expressed in a mouse model of primary biliary cirrhosis and are cytokine‐dependent

I. Mackay, R. Coppel, M. Gershwin, 2012, Clinical and experimental immunology.

The nuclear envelope from basic biology to therapy.

R. Foisner, H. Worman, 2010, Biochemical Society transactions.

Atypical antineutrophil cytoplasmic antibodies with perinuclear fluorescence in chronic inflammatory bowel diseases and hepatobiliary disorders colocalize with nuclear lamina proteins

T. Sauerbruch, U. Spengler, I. Gestmann, 1998, Hepatology.

Purification and Structural Analysis of LEM-Domain Proteins.

B. Buendia, S. Zinn-Justin, H. Worman, 2016, Methods in enzymology.

Nuclear envelope regulation of signaling cascades.

H. Worman, Jason C. Choi, 2014, Advances in experimental medicine and biology.

Inhibition of TGF-β Signaling at the Nuclear Envelope: Characterization of Interactions Between MAN1, Smad2 and Smad3, and PPM1A

F. Lallemand, Wei Wu, S. Zinn-Justin, 2013, Science Signaling.

The Carboxyl-terminal Nucleoplasmic Region of MAN1 Exhibits a DNA Binding Winged Helix Domain*

S. Zinn-Justin, B. Gilquin, H. Worman, 2006, Journal of Biological Chemistry.

Inner nuclear membrane and regulation of Smad-mediated signaling.

H. Worman, 2006, Biochimica et biophysica acta.

A mutation abolishing the ZMPSTE24 cleavage site in prelamin A causes a progeroid disorder

L. Clark, Jonathan T. Lu, G. Gundersen, 2016, Journal of Cell Science.

Intracellular trafficking and dynamics of double homeodomain proteins.

H. Worman, A. Belayew, C. Ostlund, 2005, Biochemistry.

Mitogen-Activated Protein Kinase Inhibitors Improve Heart Function and Prevent Fibrosis in Cardiomyopathy Caused by Mutation in Lamin A/C Gene

Wei Wu, H. Worman, G. Bonne, 2011, Circulation.

Lamin A variants that cause striated muscle disease are defective in anchoring transmembrane actin-associated nuclear lines for nuclear movement

G. Gundersen, H. Worman, G. Luxton, 2010, Proceedings of the National Academy of Sciences.

Inhibition of extracellular signal-regulated kinase signaling to prevent cardiomyopathy caused by mutation in the gene encoding A-type lamins.

S. Lehnart, H. Worman, G. Bonne, 2008, Human molecular genetics.

Gene regulation by human orthologs of Drosophila heterochromatin protein 1.

H. Worman, K. Hwang, 2002, Biochemical and biophysical research communications.

Intracellular trafficking of MAN1, an integral protein of the nuclear envelope inner membrane.

Wei Wu, H. Worman, F. Lin, 2002, Journal of cell science.

The human lamin B receptor/sterol reductase multigene family.

H. Worman, L. Holmer, H J Worman, 1998, Genomics.

A Human HP1 Pseudogene Maps to Chromosome 11p14

H. Worman, L. Holmer, A. Park, 1998, Somatic cell and molecular genetics.

Temsirolimus Activates Autophagy and Ameliorates Cardiomyopathy Caused by Lamin A/C Gene Mutation

S. Homma, Wei Wu, H. Worman, 2012, Science Translational Medicine.

The non-muscle ADF/cofilin-1 controls sarcomeric actin filament integrity and force production in striated muscle laminopathies

Wei Wu, H. Worman, A. Schmitt, 2021, Cell reports.

Mitogen-activated protein kinase inhibitor regulation of heart function and fibrosis in cardiomyopathy caused by lamin A/C gene mutation.

Wei Wu, H. Worman, A. Muchir, 2010, Trends in cardiovascular medicine.

Subcellular localization of SREBP1 depends on its interaction with the C-terminal region of wild-type and disease related A-type lamins.

B. Buendia, P. Roussel, S. Zinn-Justin, 2011, Experimental cell research.

Reduction of a 4q35-encoded nuclear envelope protein in muscle differentiation.

E. C. Schirmer, H. Worman, A. Hays, 2009, Biochemical and biophysical research communications.

Primary biliary cirrhosis: Report of a focus study group

David C. Jones, A. Floreani, N. Bergasa, 2004, Hepatology.

Nuclear Envelope Disease and Chromatin Organization 2009

R. Foisner, H. Worman, 2010 .

Dual Specificity Phosphatase 4 Mediates Cardiomyopathy Caused by Lamin A/C (LMNA) Gene Mutation*

S. Homma, Wei Wu, H. Worman, 2012, The Journal of Biological Chemistry.

Macrocyclic MEK1/2 inhibitor with efficacy in a mouse model of cardiomyopathy caused by lamin A/C gene mutation.

S. Homma, F. Sera, Wei Wu, 2017, Bioorganic & medicinal chemistry.

Targeting Mitogen-Activated Protein Kinase Signaling in Mouse Models of Cardiomyopathy Caused by Lamin A/C Gene Mutations.

H. Worman, A. Muchir, 2016, Methods in enzymology.

Reduced expression of A-type lamins and emerin activates extracellular signal-regulated kinase in cultured cells.

Wei Wu, H. Worman, A. Muchir, 2009, Biochimica et biophysica acta.

The nuclear envelope: target and mediator of the apoptotic process

H. Worman, L. Lindenboim, R. Stein, 2020, Cell Death Discovery.

Coronavirus Disease 2019 and Liver Injury: A Retrospective Analysis of Hospitalized Patients in New York City

H. Worman, J. Bender, 2021, Journal of clinical and translational hepatology.

13 'ANCA' in liver diseases

H. Worman, B. Terjung, 2000 .

‘ANCA’ in liver diseases

H. Worman, B. Terjung, 2000 .

Correlation of initial autoantibody profile and clinical outcome in primary biliary cirrhosis

J. Węsierska‐Gądek, E. Hitchman, E. Penner, 2006, Hepatology.

Emerin organizes actin flow for nuclear movement and centrosome orientation in migrating fibroblasts

G. Gundersen, H. Worman, Wakam Chang, 2013, Molecular biology of the cell.

Jaundice in patients with COVID‐19

H. Worman, J. Bender, 2021, JGH open : an open access journal of gastroenterology and hepatology.

Nuclear envelope-localized torsinA-LAP1 complex regulates hepatic VLDL secretion and steatosis.

Michael J. Lee, W. Dauer, H. Worman, 2019, The Journal of clinical investigation.

The LINC Complex

G. Gundersen, H. Worman, 2018, Methods in Molecular Biology.

Persistence of autoantibodies against recombinant mitochondrial and nuclear pore proteins after orthotopic liver transplantation for primary biliary cirrhosis.

M. Manns, M. Gershwin, M. Rizzetto, 1997, Journal of autoimmunity.

Quality of life and everyday activities in patients with primary biliary cirrhosis

M. Kaplan, K. Lindor, E. Gold, 2007, Hepatology.

Primary biliary cirrhosis and the nuclear pore complex.

J. Anaya, D. Bogdanos, M. Gershwin, 2012, Autoimmunity reviews.

Antinuclear antibodies specific for primary biliary cirrhosis.

Howard J Worman, H. Worman, J. Courvalin, 2003, Autoimmunity reviews.

Neurofilament light polypeptide gene N98S mutation in mice leads to neurofilament network abnormalities and a Charcot-Marie-Tooth Type 2E phenotype.

R. Liem, Chyuan-Sheng Lin, H. Worman, 2015, Human molecular genetics.

New messages in the nuclear envelope

W. Dauer, H. Worman, 2010, Cell cycle.

Linker of nucleoskeleton and cytoskeleton (LINC) complex-mediated actin-dependent nuclear positioning orients centrosomes in migrating myoblasts

G. Gundersen, H. Worman, Wakam Chang, 2015, Nucleus.

The Nuclear Envelope: An Intriguing Focal Point for Neurogenetic Disease

W. Dauer, H. Worman, 2014, Neurotherapeutics.

Letter to the Editor: 1H, 13C and 15N resonance assignments of the C-terminal domain of human lamin A/C

S. Zinn-Justin, H. Worman, I. Krimm, 2002, Journal of biomolecular NMR.

Caused by Lamin A / C Gene Mutation Temsirolimus Activates Autophagy and Ameliorates Cardiomyopathy

S. Homma, Wei Wu, H. Worman, 2012 .

Prenylated Prelamin A Interacts with Narf, a Novel Nuclear Protein*

H. Worman, Racine M. Barton, Howard J. Worman, 1999, The Journal of Biological Chemistry.

Hydrophobic cluster analysis reveals a third chromodomain in the Tetrahymena Pdd1p protein of the chromo superfamily.

I. Callebaut, H. Worman, J. Mornon, 1997, Biochemical and biophysical research communications.

Ryanodine receptor remodeling in cardiomyopathy and muscular dystrophy caused by lamin A/C gene mutation.

S. Reiken, A. Marks, Wei Wu, 2020, Human molecular genetics.

Acute liver injury associated with a newer formulation of the herbal weight loss supplement Hydroxycut

H. Worman, J. Araujo, 2015, BMJ Case Reports.

Genome‐wide association study in mice identifies loci affecting liver‐related phenotypes including Sel1l influencing serum bile acids

A. Gharavi, K. Kiryluk, Wei Wu, 2016, Hepatology.

Escalating interferon-alpha-2b dose for patients with chronic hepatitis C.

D. McMahon, H. Worman, R. Ligresti, 1998, Hepato-gastroenterology.

ATPase activity and ATP-dependent proton translocation in plasma membrane vesicles of turtle bladder epithelial cells.

H. Worman, S. Youmans, W. Brodsky, 1983, Biochimica et biophysica acta.

Functional status of patients with primary biliary cirrhosis

E. Gold, M. Gershwin, H. Worman, 2002, American Journal of Gastroenterology.

Molecular Pathology of Laminopathies.

H. Worman, Ji-yeon Shin, 2021, Annual review of pathology.

Muscular Dystrophy Mutations Impair the Nuclear Envelope Emerin Self-assembly Properties.

B. Buendia, S. Zinn-Justin, H. Worman, 2015, ACS chemical biology.

Osmotic water permeability of small intestinal brush-border membranes

H. Worman, M. Field, 2005, The Journal of Membrane Biology.

Comparative studies of antimitochondrial autoantibodies in sera and bile in primary biliary cirrhosis

J. Neuberger, R. Coppel, A. Nishio, 1997, Hepatology.

Bioartificial liver support for fulminant hepatic failure.

H. Worman, Robert S. Brown, 1999, World Journal of Gastroenterology.

Correction: Cardiomyocyte-Specific Expression of Lamin A Improves Cardiac Function in Lmna −/− Mice

Richard L. Frock, B. Kennedy, P. Rabinovitch, 2012, PLoS ONE.

Biliary cystadenocarcinoma arising in a liver with fibropolycystic disease.

S. Thung, H. Worman, M. Schwartz, 1993, Archives of Pathology & Laboratory Medicine.

An Introduction to Molecular Biology and Recombinant DNA Technology for the Hepatologist

H. Worman, P. Berk, 1992, Seminars in liver disease.

Both lamin A and lamin C mutations cause lamina instability as well as loss of internal nuclear lamin organization.

H. Worman, J. Endert, Cecilia Östlund, 2005, Experimental cell research.

Post‐mortem findings in Dunnigan‐type familial partial lipodystrophy

H. Worman, A. Lüdtke, H. Schmidt, 2010, Diabetic Medicine.

Re‐evaluating the use of growth factors as adjuvant treatment of chronic hepatitis C

H. Worman, 2007, Hepatology.

Mitogen-Activated Protein Kinase Inhibitors Improve Heart Function and Prevent Fibrosis in Cardiomyopathy Caused by Mutation in Lamin A/C Gene

Wei Wu, H. Worman, G. Bonne, 2011, Circulation.

Functional interaction of torsinA and its activators in liver lipid metabolism

W. Dauer, H. Worman, J. Murray, 2023, bioRxiv.

Nuclear Membrane Dynamics and Reassembly in Living Cells: Targeting of an Inner Nuclear Membrane Protein in Interphase and Mitosis

J. Lippincott-Schwartz, J. Ellenberg, E. Siggia, 1997, The Journal of cell biology.

Atypical antineutrophil cytoplasmic antibodies with perinuclear fluorescence in chronic inflammatory bowel diseases and hepatobiliary disorders colocalize with nuclear lamina proteins

T. Sauerbruch, U. Spengler, I. Gestmann, 1998, Hepatology.

Epidermal expression of the truncated prelamin A causing Hutchinson-Gilford progeria syndrome: effects on keratinocytes, hair and skin.

C. Stewart, H. Worman, Yuexia Wang, 2008, Human molecular genetics.

Diseases of the nuclear envelope.

H. Worman, C. Ostlund, Yuexia Wang, 2010, Cold Spring Harbor perspectives in biology.

Approach to the patient with alcoholic liver disease.

H. Worman, 2005, The virtual mentor : VM.

Primary biliary cirrhosis and the nuclear pore complex.

J. Anaya, D. Bogdanos, M. Gershwin, 2012, Autoimmunity reviews.

Excessive use of urine cultures for inpatients.

H. Worman, 1987, Annals of internal medicine.

Dynamic regulation of hepatic lipid metabolism by torsinA and its activators

H. Worman, A. Hernandez-Ono, Cecilia Östlund, 2024, JCI insight.

Prelamin A and ZMPSTE24 in premature and physiological aging

H. Worman, Susan Michaelis, 2023, Nucleus.