T. Neelands

发表

Expression of Functional GABAA Receptors in Transfected L929 Cells Isolated by Immunomagnetic Bead Separation

L. Greenfield, R. Macdonald, S. Fang, 1997, Neuropharmacology.

BL-1249 [(5,6,7,8-Tetrahydro-naphthalen-1-yl)-[2-(1H-tetrazol-5-yl)-phenyl]-amine]: A Putative Potassium Channel Opener with Bladder-Relaxant Properties

T. Neelands, Ronald J. Knox, S. Tertyshnikova, 2005, Journal of Pharmacology and Experimental Therapeutics.

Distribution and functional characterization of human Nav1.3 splice variants

M Gopalakrishnan, T. Neelands, M. Gopalakrishnan, 2005, The European journal of neuroscience.

[3H]A-778317 [1-((R)-5-tert-Butyl-indan-1-yl)-3-isoquinolin-5-yl-urea]: a Novel, Stereoselective, High-Affinity Antagonist Is a Useful Radioligand for the Human Transient Receptor Potential Vanilloid-1 (TRPV1) Receptor

A. Gomtsyan, Chih-Hung Lee, T. Neelands, 2007, Journal of Pharmacology and Experimental Therapeutics.

Small‐conductance calcium‐activated potassium currents in mouse hyperexcitable denervated skeletal muscle

J. Adelman, J. Maylie, T. Neelands, 2001, The Journal of physiology.

Repeated dosing of ABT-102, a potent and selective TRPV1 antagonist, enhances TRPV1-mediated analgesic activity in rodents, but attenuates antagonist-induced hyperthermia

A. Gomtsyan, P. Mantyh, J. Sullivan, 2009, Pain.

Incorporation of the pi subunit into functional gamma-aminobutyric Acid(A) receptors.

R. Macdonald, T. Neelands, R. L. MacDonald, 1999, Molecular pharmacology.

Involvement of the TTX-resistant sodium channel Nav 1.8 in inflammatory and neuropathic, but not post-operative, pain states

J. Sullivan, C. Shieh, S. Baker, 2006, Pain.

SK channels are necessary but not sufficient for denervation‐induced hyperexcitability

J. Adelman, J. Maylie, T. Neelands, 2002, Muscle & nerve.

Comparative analysis of inactivated-state block of N-type (Cav2.2) calcium channels

D. Donnelly-roberts, A. Swensen, T. Neelands, 2011, Inflammation Research.

A Novel, Stereoselective, High-Affinity Antagonist is a Useful Radioligand For The Human TRPV1 Receptor

Chih-Hung Lee, T. Neelands, R. Moreland, 2007 .

Properties of recombinant gamma-aminobutyric acid A receptor isoforms containing the alpha 5 subunit subtype.

R. Macdonald, T. Neelands, E. Burgard, 1996, Molecular pharmacology.

GABAA Receptors Expressed in Undifferentiated Human Teratocarcinoma NT2 Cells Differ from Those Expressed by Differentiated NT2-N Cells

R. Macdonald, T. Neelands, Jie Zhang, 1999, The Journal of Neuroscience.

A-425619 [1-Isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a Novel and Selective Transient Receptor Potential Type V1 Receptor Antagonist, Blocks Channel Activation by Vanilloids, Heat, and Acid

A. Gomtsyan, J. Sullivan, Chih-Hung Lee, 2005, Journal of Pharmacology and Experimental Therapeutics.

Spontaneous and gamma-aminobutyric acid (GABA)-activated GABA(A) receptor channels formed by epsilon subunit-containing isoforms.

M. Bianchi, R. Macdonald, T. Neelands, 1999, Molecular pharmacology.

Discovery of (R)-1-(7-chloro-2,2-bis(fluoromethyl)chroman-4-yl)-3-(3-methylisoquinolin-5-yl)urea (A-1165442): a temperature-neutral transient receptor potential vanilloid-1 (TRPV1) antagonist with analgesic efficacy.

A. Gomtsyan, J. Segreti, A. King, 2014, Journal of medicinal chemistry.

Coexpression and activation of TRPV1 suppress the activity of the KCNQ2/3 channel

T. Neelands, C. Surowy, P. Honore, 2011, The Journal of general physiology.

A-995662 [(R)-8-(4-methyl-5-(4-(trifluoromethyl)phenyl)oxazol-2-ylamino)-1,2,3,4-tetrahydronaphthalen-2-ol], a novel, selective TRPV1 receptor antagonist, reduces spinal release of glutamate and CGRP in a rat knee joint pain model

S. Baker, T. Neelands, P. Honore, 2010, PAIN.

Characterization of A-425619 at native TRPV1 receptors: a comparison between dorsal root ganglia and trigeminal ganglia.

T. Neelands, R. Moreland, H. McDonald, 2008, European journal of pharmacology.

TRPV1 Receptors in the CNS Play a Key Role in Broad-Spectrum Analgesia of TRPV1 Antagonists

A. Gomtsyan, J. Sullivan, M. Decker, 2006, The Journal of Neuroscience.

Pharmacology of Modality-Specific Transient Receptor Potential Vanilloid-1 Antagonists That Do Not Alter Body Temperature

A. Gomtsyan, P. Mantyh, J. Segreti, 2012, Journal of Pharmacology and Experimental Therapeutics.

Synthesis and Pharmacology of (Pyridin-2-yl)methanol Derivatives as Novel and Selective Transient Receptor Potential Vanilloid 3 Antagonists.

Bruce Clapham, Bin Li, A. Gomtsyan, 2016, Journal of medicinal chemistry.

Inhibition of calcium-dependent motility of cochlear outer hair cells by the protein kinase inhibitor, ML-9

T. Neelands, D. Coling, S. Bartolami, 1998, Hearing Research.

Respiration and parturition affected by conditional overexpression of the Ca2+-activated K+ channel subunit, SK3.

P. Seeburg, R. Sprengel, T. Storck, 2000, Science.

Functional expression of L-, N-, P/Q-, and R-type calcium channels in the human NT2-N cell line.

R. Macdonald, T. Neelands, A. King, 2000, Journal of neurophysiology.

Biological Characterization of F508delCFTR Protein Processing by the CFTR Corrector ABBV-2222/GLPG2222

C. Tse, D. Cyr, A. Swensen, 2019, The Journal of Pharmacology and Experimental Therapeutics.

Mechanistic insights into the analgesic efficacy of A-1264087, a novel neuronal Ca(2+) channel blocker that reduces nociception in rat preclinical pain models.

A. Swensen, Chih-Hung Lee, T. Neelands, 2014, The journal of pain : official journal of the American Pain Society.

(R)-(5-tert-Butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)-urea (ABT-102) Blocks Polymodal Activation of Transient Receptor Potential Vanilloid 1 Receptors in Vitro and Heat-Evoked Firing of Spinal Dorsal Horn Neurons in Vivo

A. Gomtsyan, J. Sullivan, Chih-Hung Lee, 2008, Journal of Pharmacology and Experimental Therapeutics.

Contrasting actions of lanthanum on different recombinant gamma-aminobutyric acid receptor isoforms expressed in L929 fibroblasts.

R. Macdonald, T. Neelands, N. Saxena, 1997, Molecular pharmacology.

Molecular Determinants of Species-Specific Activation or Blockade of TRPA1 Channels

P. Hajduk, J. R. Huth, Chaohong Sun, 2008, The Journal of Neuroscience.

Elevated temperatures alter TRPV1 agonist-evoked excitability of dorsal root ganglion neurons

T. Neelands, C. Surowy, M. Jarvis, 2008, Inflammation Research.

TRPV1b overexpression negatively regulates TRPV1 responsiveness to capsaicin, heat and low pH in HEK293 cells

T. Neelands, R. Moreland, P. Kroeger, 2006, Journal of neurochemistry.

Expression and purification of human TRPV1 in baculovirus-infected insect cells for structural studies.

M. Chiu, T. Neelands, R. Moreland, 2009, Protein expression and purification.

A-1048400 is a novel, orally active, state-dependent neuronal calcium channel blocker that produces dose-dependent antinociception without altering hemodynamic function in rats.

A. Swensen, T. Neelands, T. Vortherms, 2012, Biochemical pharmacology.

Activation of TRPA1 Channels by the Fatty Acid Amide Hydrolase Inhibitor 3′-Carbamoylbiphenyl-3-yl cyclohexylcarbamate (URB597)

T. Holzman, T. Neelands, R. Moreland, 2007, Molecular Pharmacology.

Structural mechanism for STI-571 inhibition of abelson tyrosine kinase.

P. Seeburg, R. Sprengel, J. Kuriyan, 2000, Science.

Transient receptor potential A1 mediates an osmotically activated ion channel

T. Neelands, R. Moreland, C. Faltynek, 2008, The European journal of neuroscience.

Domains Responsible for Constitutive and Ca2+-Dependent Interactions between Calmodulin and Small Conductance Ca2+-Activated Potassium Channels

A. Janowsky, B. Fakler, J. Adelman, 1999, The Journal of Neuroscience.

Short Communication Elevated temperatures alter TRPV1 agonist-evoked excitability of dorsal root ganglion neurons

T. Neelands, C. Surowy, M. Jarvis, 2008 .

GABAA Receptor Pharmacology and Subtype mRNA Expression in Human Neuronal NT2-N Cells

L. Greenfield, R. Turner, R. Turner, 1998, The Journal of Neuroscience.

Development and validation of a medium-throughput electrophysiological assay for KCNQ2/3 channel openers using QPatch HT.

T. Neelands, C. Surowy, M. Jarvis, 2013, Assay and drug development technologies.

Acidification of rat TRPV1 alters the kinetics of capsaicin responses

T. Neelands, C. Surowy, M. Jarvis, 2005, Molecular pain.

CryoEM structures of the human CLC-2 voltage gated chloride channel reveal a ball and chain gating mechanism

G. Pintilie, M. Maduke, T. Neelands, 2023, bioRxiv.

Activation of TRPA 1 Channels by the Fatty Acid Amide Hydrolase Inhibitor 3-Carbamoylbiphenyl-3-yl cyclohexylcarbamate ( URB 597 )

T. Holzman, T. Neelands, R. Moreland, 2007 .

534 Defining a mechanistic link between TRPV3 activity and psoriasis through IL-1α and EGFR signaling pathways

S. Gauld, T. Neelands, L. Miller, 2016 .

Discovery of (R)-(3-fluoropyrrolidin-1-yl)(6-((5-(trifluoromethyl)pyridin-2-yl)oxy)quinolin-2-yl)methanone (ABBV-318) and analogs as small molecule Nav1.7/ Nav1.8 blockers for the treatment of pain.

G. Gintant, R. Gum, T. Neelands, 2022, Bioorganic & medicinal chemistry.

Substituted Indazoles as Nav1.7 Blockers for the Treatment of Pain.

R. Gum, T. Neelands, M. Kort, 2016, Journal of medicinal chemistry.

A. Gomtsyan, J. Sullivan, Chih-Hung Lee, 2008, Journal of Pharmacology and Experimental Therapeutics.

Mechanistic insights into the analgesic efficacy of A-1264087, a novel neuronal Ca(2+) channel blocker that reduces nociception in rat preclinical pain models.

A. Swensen, Chih-Hung Lee, T. Neelands, 2014, The journal of pain : official journal of the American Pain Society.

Synthesis and Pharmacology of (Pyridin-2-yl)methanol Derivatives as Novel and Selective Transient Receptor Potential Vanilloid 3 Antagonists.

A. Gomtsyan, J. Segreti, R. Henry, 2016, Journal of medicinal chemistry.

CryoEM structures of the human CLC-2 voltage-gated chloride channel reveal a ball-and-chain gating mechanism

G. Pintilie, M. Maduke, T. Neelands, 2024, eLife.