S. Farrow

发表

The importance of chronobiology to drug discovery

T. Willson, S. Farrow, R. Solari, 2012, Expert opinion on drug discovery.

Glucocorticoid-induced osteopenia in the mouse as assessed by histomorphometry, microcomputed tomography, and biochemical markers.

S. Farrow, I. Uings, F. Mclaughlin, 2002, Bone.

Induction of the E-selectin promoter by interleukin 1 and tumour necrosis factor alpha, and inhibition by glucocorticoids.

S. Farrow, K. Ray, M. Daly, 1997, The Biochemical journal.

Use of gene expression profiling to identify a novel glucocorticoid sensitivity determining gene, BMPRII

R. Donn, A. Stevens, S. Farrow, 2007, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Glucocorticoid Ligands Specify Different Interactions with NF-κB by Allosteric Effects on the Glucocorticoid Receptor DNA Binding Domain*

H. Garside, A. Stevens, B. Houle, 2004, Journal of Biological Chemistry.

A Zebrafish Compound Screen Reveals Modulation of Neutrophil Reverse Migration as an Anti-Inflammatory Mechanism

V. Kadirkamanathan, D. Irimia, S. Walmsley, 2014, Science Translational Medicine.

Cell receptors and cell signalling

S. Farrow, I. Uings, I J Uings, 2000, Molecular pathology : MP.

Liver X Receptor Agonists Increase Airway Reactivity in a Model of Asthma via Increasing Airway Smooth Muscle Growth1

T. Willson, M. Belvisi, S. Farrow, 2008, The Journal of Immunology.

Increasing Airway Smooth Muscle Growth Reactivity in a Model of Asthma via Liver X Receptor Agonists Increase Airway

T. Willson, M. Belvisi, S. Farrow, 2008 .

Novel Role for the Liver X Nuclear Receptor in the Suppression of Lung Inflammatory Responses*

T. Willson, M. Belvisi, S. Farrow, 2007, Journal of Biological Chemistry.

Death Receptor 3 regulates distinct pathological attributes of acute versus chronic murine allergic lung inflammation

P. Taylor, E. Kidd, S. Farrow, 2017, Cellular immunology.

Inhibition of LPS Stimulated COPD Macrophage Inflammatory Gene Expression by Dexamethasone and the p38 MAPK Inhibitor SB706504

D. Ray, Dave Singh, S. Farrow, 2008 .

Encapsulation of the p38 MAPK inhibitor GSK 678361A in nanoparticles for inflammatory‐based disease states

S. Farrow, C. Scott, M. Greene, 2016 .

Cloning of a bcl-2 homologue by interaction with adenovirus E1B 19K

J. Martinou, I. Martinou, Julia H. M. White, 1995, Nature.

Secreted autotaxin through LPA suppresses chemotaxis and tumor infiltration of CD8+ T Cells

T. Schumacher, J. Koster, J. Haanen, 2020 .

Protein Kinase C Modulates Tumor Necrosis Factor-related Apoptosis-inducing Ligand-induced Apoptosis by Targeting the Apical Events of Death Receptor Signaling*

G. Cohen, M. MacFarlane, S. Farrow, 2003, Journal of Biological Chemistry.

Effects of the cyclin‐dependent kinase inhibitor R‐roscovitine on eosinophil survival and clearance

E. Chilvers, A. Cowburn, S. Farrow, 2011, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Ligand modulation of REV-ERBα function resets the peripheral circadian clock in a phasic manner

A. Loudon, R. Donn, S. Farrow, 2008, Journal of Cell Science.

Treatment with a peroxisomal proliferator activated receptor gamma agonist has a modest effect in the allergen challenge model in asthma: a randomised controlled trial.

S. Farrow, D. Quinn, P. Bareille, 2010, Respiratory medicine.

Circadian timing in the lung; a specific role for bronchiolar epithelial cells.

A. Loudon, D. Ray, S. Farrow, 2009, Endocrinology.

A New Strategy for the Identification of Novel Molecules with Targeted Proresolution of Inflammation Properties

D. Gilroy, S. Farrow, J. Bystrom, 2009, The Journal of Immunology.

e- Blood Transcriptomic analyses of murine resolution-phase macrophages

E. Camon, R. Lovering, D. Gilroy, 2011 .

Novel Molecules with Targeted Proresolution A New Strategy for the Identification of Bystrom

D. Gilroy, S. Farrow, Justine Newson, 2009 .

New members of the Bcl-2 family and their protein partners.

S. Farrow, R. Brown, Robin Brown, 1996, Current opinion in genetics & development.

Chronic glucocorticoid exposure potentiates placental chorionic plate artery constriction: implications for aberrant fetoplacental vascular resistance in fetal growth restriction.

D. Ray, C. Sibley, P. Baker, 2013, Endocrinology.

Pharmacological properties of the enhanced-affinity glucocorticoid fluticasone furoate in vitro and in an in vivo model of respiratory inflammatory disease.

S. Farrow, I. Uings, K. Biggadike, 2007, American journal of physiology. Lung cellular and molecular physiology.

Inhibition of NF-κB by a cell permeable form of IκBα induces apoptosis in eosinophils

C. Haslett, R. Hay, S. Farrow, 2005 .

A cell-based bioluminescence assay reveals dose-dependent and contextual repression of AP-1-driven gene expression by BACH2

K. Okkenhaug, Jingqing Yang, S. Walker, 2020, Scientific Reports.

Recent advances in chronotherapy for the management of asthma

D. Ray, S. Farrow, H. Durrington, 2014 .

Hypoxia causes IL‐8 secretion, Charcot Leyden crystal formation, and suppression of corticosteroid‐induced apoptosis in human eosinophils

E. Chilvers, A. Cowburn, J. Deighton, 2017, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Estrogen Receptor β: Expression Profile and Possible Anti-Inflammatory Role in Disease

M. Belvisi, S. Farrow, M. Birrell, 2008, Journal of Pharmacology and Experimental Therapeutics.

Nuclear receptors: doubling up in the lung.

S. Farrow, 2008, Current opinion in pharmacology.

Designing corticosteroid drugs for pulmonary selectivity.

S. Farrow, I. Uings, K. Biggadike, 2004, Proceedings of the American Thoracic Society.

Cigarette smoke extract induced cytokine and chemokine gene expression changes in COPD macrophages.

Dave Singh, S. Farrow, Laurie Scott, 2008, Cytokine.

Discovery of GW870086: a potent anti‐inflammatory steroid with a unique pharmacological profile

S. Farrow, I. Uings, K. Biggadike, 2013, British journal of pharmacology.

Mometasone furoate is a less specific glucocorticoid than fluticasone propionate

S. Farrow, I. Uings, E. Meldrum, 2002, European Respiratory Journal.

Apoptosis in a Fas‐resistant, T‐cell receptor‐sensitive human leukaemic T‐cell clone

J. A. Payne, B. Champion, S. Farrow, 1997, Immunology.

Inhibition of nuclear factor‐κB activation un‐masks the ability of TNF‐α to induce human eosinophil apoptosis

C. Haslett, C. Ward, R. Hay, 2002 .

Studies on the interaction between TWEAK and the death receptor WSL‐1/TRAMP (DR3)

J. Tschopp, J. Bodmer, M. Owen, 2000, FEBS letters.

A pharmacological approach to enhancing the therapeutic index of corticosteroids in airway inflammatory disease.

S. Farrow, I. Uings, 2005, Current opinion in pharmacology.

Inhibition of nuclear factor-kappaB activation un-masks the ability of TNF-alpha to induce human eosinophil apoptosis.

C. Haslett, C. Ward, R. Hay, 2002, European journal of immunology.

Functional Genomics for Target Identification

D. Gianni, S. Farrow, 2020, SLAS discovery : advancing life sciences R & D.

Optimized chemical probes for REV-ERBα.

A. Loudon, T. Willson, S. Farrow, 2013, Journal of medicinal chemistry.

Synthesis and biological properties of novel phosphotriesters: a new approach to the introduction of biologically active nucleotides into cells.

R. T. Walker, E. De Clercq, J. Balzarini, 1990, Journal of medicinal chemistry.

An epithelial circadian clock controls pulmonary inflammation and glucocorticoid action

A. Loudon, F. DeMayo, S. Farrow, 2014, Nature Medicine.

Identification of benzopyrone as a common structural feature in compounds with anti-inflammatory activity in a zebrafish phenotypic screen

M. J. Foulkes, P. Ingham, R. Flower, 2016, Disease Models & Mechanisms.

Cloning of a bcl-2 homologue by interaction with adenovirus E1B 19K

J. Martinou, I. Martinou, Julia H. M. White, 1995, Nature.

Resolution-phase macrophages possess a unique inflammatory phenotype that is controlled by cAMP

D. Gilroy, P. Colville-Nash, N. Van Rooijen, 2008, Blood.

Transcriptomic analyses of murine resolution-phase macrophages.

Ruth C Lovering, Sonia Shah, Sonia Shah, 2011, Blood.

PAK proteins and YAP-1 signalling downstream of integrin beta-1 in myofibroblasts promote liver fibrosis

S. Friedman, N. Hanley, C. Streuli, 2016, Nature Communications.

A death-domain-containing receptor that mediates apoptosis

D. Goeddel, S. Farrow, K. Pun, 1996, Nature.

DR3 Regulates Negative Selection during Thymocyte Development

A. Thern, M. Owen, S. Farrow, 2001, Molecular and Cellular Biology.

Pin1 promotes GR transactivation by enhancing recruitment to target genes

A. Loudon, D. Ray, S. Farrow, 2013, Nucleic acids research.

The Relationship between Intranuclear Mobility of the NF-κB Subunit p65 and Its DNA Binding Affinity*

E. Stylianou, S. Farrow, B. Hayes, 2006, Journal of Biological Chemistry.

A ligand-specific kinetic switch regulates glucocorticoid receptor trafficking and function

D. Ray, James M. Woolven, S. Farrow, 2013, Journal of Cell Science.

Interferon-inducible factor 16 is a novel modulator of glucocorticoid action

D. Ray, R. Donn, P. A. Wilson, 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Duplication of the DR3 gene on human chromosome 1p36 and its deletion in human neuroblastoma.

V. Valentine, S. Farrow, V. Kidd, 1998, Genomics.

Glucocorticoid receptor regulates accurate chromosome segregation and is associated with malignancy

Stephen S. Taylor, D. Ray, D. Spiller, 2015, Proceedings of the National Academy of Sciences.

Glucocorticoids impair type I IFN signalling and enhance rhinovirus replication.

S. Johnston, S. Farrow, R. Solari, 2020, European journal of pharmacology.

NF-κB Activation Is a Critical Regulator of Human Granulocyte Apoptosis in Vitro*

C. Haslett, C. Ward, E. Chilvers, 1999, The Journal of Biological Chemistry.

The nuclear receptor REV-ERBα mediates circadian regulation of innate immunity through selective regulation of inflammatory cytokines

A. Loudon, D. Ray, Dave Singh, 2011, Proceedings of the National Academy of Sciences.

Modulation of Tumor Necrosis Factor Apoptosis-inducing Ligand- induced NF-κB Activation by Inhibition of Apical Caspases*

G. Cohen, M. MacFarlane, S. Farrow, 2001, The Journal of Biological Chemistry.

Genomic structure, expression, and chromosome mapping of the mouse homologue for the WSL-1 (DR3, Apo3, TRAMP, LARD, TR3, TNFRSF12) gene

A. Thern, M. Owen, S. Farrow, 2001, Immunogenetics.

Inhibition of cyclo-oxygenase 2 expression in colon cells by the chemopreventive agent curcumin involves inhibition of NF-κB activation via the NIK/IKK signalling complex

L. Howells, S. Plummer, S. Farrow, 1999, Oncogene.

The Methyltransferase WBSCR22/Merm1 Enhances Glucocorticoid Receptor Function and Is Regulated in Lung Inflammation and Cancer

D. Ray, R. Donn, N. Hanley, 2014, The Journal of Biological Chemistry.

Inhibition of Lipopolysaccharide-Stimulated Chronic Obstructive Pulmonary Disease Macrophage Inflammatory Gene Expression by Dexamethasone and the p38 Mitogen-Activated Protein Kinase Inhibitor N-cyano-N′-(2-{[8-(2,6-difluorophenyl)-4-(4-fluoro-2-methylphenyl)-7-oxo-7,8-dihydropyrido[2,3-d] pyrimidi

D. Ray, Dave Singh, S. Farrow, 2008, Journal of Pharmacology and Experimental Therapeutics.

The transrepression arm of glucocorticoid receptor signaling is protective in mutant huntingtin-mediated neurodegeneration

J. L. Smalley, M. Butterworth, G. Cohen, 2015, Cell Death and Differentiation.

Prostaglandin D2 and Its Metabolites Induce Caspase-Dependent Granulocyte Apoptosis That Is Mediated Via Inhibition of IκBα Degradation Using a Peroxisome Proliferator-Activated Receptor-γ-Independent Mechanism1

C. Haslett, C. Ward, S. Farrow, 2002, The Journal of Immunology.

Proliferator-Activated Receptor-Degradation Using a Peroxisome α B κ That Is Mediated Via Inhibition of I Caspase-Dependent Granulocyte Apoptosis and Its Metabolites Induce 2 Prostaglandin

C. Haslett, C. Ward, S. Farrow, 2002 .

IFN‐γ synergistically enhances LPS signalling in alveolar macrophages from COPD patients and controls by corticosteroid‐resistant STAT1 activation

S. Farrow, T. Southworth, J. Plumb, 2012, British journal of pharmacology.

The effects of dexamethasone on cigarette smoke induced gene expression changes in COPD macrophages.

Dave Singh, S. Farrow, Lauren M Kent, 2010, International immunopharmacology.

Resolution-phase macrophages possess a unique inflammatory and bactericidal phenotype that is controlled by CAMP

D. Gilroy, P. Colville-Nash, S. Farrow, 2008 .

Serum and Glucocorticoid–Regulated Kinase 1 Regulates Neutrophil Clearance during Inflammation Resolution

William J. Zuercher, P. Ingham, W. Zuercher, 2014, The Journal of Immunology.

The circadian clock and asthma

David W Ray, A. Loudon, D. Ray, 2013, Thorax.

Prostaglandin D2 and its metabolites induce caspase-dependent granulocyte apoptosis that is mediated via inhibition of I kappa B alpha degradation using a peroxisome proliferator-activated receptor-gamma-independent mechanism.

C. Haslett, C. Ward, S. Farrow, 2002, Journal of immunology.

Estrogen Receptor β: Expression Profile and Possible Anti-Inflammatory Role in Disease

M. Belvisi, S. Farrow, M. Birrell, 2008 .

Death receptors, NF-κB activation and apoptosis: the potential for therapeutic intervention

S. Farrow, 1999 .

Death receptors, NF-kappa B activation and apoptosis: the potential for therapeutic intervention.

S. Farrow, 1999, Biochemical Society Transactions.