S. Iwai

发表

Identification of cryptochrome DASH from vertebrates

K. Kuma, T. Todo, H. Toh, 2004, Genes to cells : devoted to molecular & cellular mechanisms.

Xeroderma pigmentosum group C protein complex is the initiator of global genome nucleotide excision repair.

P. J. van der Spek, J. Hoeijmakers, K. Sugasawa, 1998, Molecular cell.

Polymerization by DNA polymerase eta is blocked by cis-diamminedichloroplatinum(II) 1,3-d(GpTpG) cross-link: implications for cytotoxic effects in nucleotide excision repair-negative tumor cells.

F. Hanaoka, S. Iwai, C. Masutani, 2010, Carcinogenesis.

Conserved XPB core structure and motifs for DNA unwinding: implications for pathway selection of transcription or excision repair.

J. Tainer, F. Hanaoka, S. Iwai, 2006, Molecular cell.

Topoisomerase I-driven repair of UV-induced damage in NER-deficient cells

Samuel H. Wilson, Y. Pommier, T. Matsunaga, 2020, Proceedings of the National Academy of Sciences.

Diversity of the damage recognition step in the global genomic nucleotide excision repair in vitro.

K. Sugasawa, F. Hanaoka, S. Iwai, 2001, Mutation research.

A multistep damage recognition mechanism for global genomic nucleotide excision repair.

K. Sugasawa, F. Hanaoka, S. Iwai, 2001, Genes & development.

Characterization of DNA Recognition by the Human UV-damaged DNA-binding Protein*

F. Hanaoka, J. Kondo, S. Iwai, 1999, The Journal of Biological Chemistry.

Mechanism and regulation of DNA damage recognition in nucleotide excision repair

W. Sakai, K. Sugasawa, S. Iwai, 2019, Genes and Environment.

Kobe University Repository : Kernel タイトル Tit le SUMOylat ion of xeroderma pigmentosum group C protein regulates DNA damage recognit ion during nucleot ide excision repair

W. Sakai, K. Sugasawa, F. Hanaoka, 2018 .

SUMOylation of xeroderma pigmentosum group C protein regulates DNA damage recognition during nucleotide excision repair

W. Sakai, K. Sugasawa, F. Hanaoka, 2015, Scientific Reports.

The Molecular Basis of CRL4DDB2/CSA Ubiquitin Ligase Architecture, Targeting, and Activation

K. Sugasawa, F. Hanaoka, M. Wakasugi, 2011, Cell.

In Vivo Destabilization and Functional Defects of the Xeroderma Pigmentosum C Protein Caused by a Pathogenic Missense Mutation

K. Sugasawa, F. Hanaoka, D. Orioli, 2007, Molecular and Cellular Biology.

The XPC-HR23B complex displays high affinity and specificity for damaged DNA in a true-equilibrium fluorescence assay.

G. Krauss, K. Sugasawa, F. Hanaoka, 2002, Biochemistry.

Preparation of Oligodeoxyribonucleotides Containing the Pyrimidine(6–4)pyrimidone Photoproduct by Using a Dinucleotide Building Block

S. Iwai, 2013, Current protocols in nucleic acid chemistry.

Structural Basis of UV DNA-Damage Recognition by the DDB1–DDB2 Complex

P. Jeffrey, N. Pavletich, Y. Nakatani, 2008, Cell.

Characterization of distamycin A binding to damaged DNA.

S. Yoshikawa, T. Kodama, S. Iwai, 2008, Bioorganic & medicinal chemistry.

Xeroderma pigmentosum group C protein interacts physically and functionally with thymine DNA glycosylase

K. Sugasawa, F. Hanaoka, S. Iwai, 2003, The EMBO journal.

A molecular mechanism for DNA damage recognition by the xeroderma pigmentosum group C protein complex.

K. Sugasawa, F. Hanaoka, S. Iwai, 2002, DNA Repair.

Synthesis of Thymine Glycol Containing Oligonucleotides from a Building Block with the Oxidized Base.

S. Iwai, 2000, Angewandte Chemie.

Chemical synthesis of oligonucleotides containing the (6-4) photoproduct at the thymine-cytosine site and its repair by (6-4) photolyase.

T. Todo, S. Iwai, T. Mizukoshi, 1999, Nucleosides & nucleotides.

Benzimidazolium triflate-activated synthesis of (6-4) photoproduct-containing oligonucleotides and its application.

F. Hanaoka, S. Iwai, C. Masutani, 1999, Nucleic acids research.

Synthesis of a Phosphoramidite Coupling Unit of the Pyrimidine (6−4) Pyrimidone Photoproduct and Its Incorporation into Oligodeoxynucleotides

E. Ohtsuka, S. Iwai, H. Kamiya, 1996 .

Efficient conversion of thymine glycol into the formamide lesion in oligonucleotides

S. Iwai, Tatsuya Toga, J. Yamamoto, 2009 .

Lesion bypass by S. cerevisiae Pol ζ alone.

T. Kunkel, Sara K. Binz, S. Iwai, 2011, DNA repair.

The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase η

Chikahide Masutani, Shigenori Iwai, Fumio Hanaoka, 1999, Nature.

Synthesis of oligoribonucleotides by the phosphoramidite approach using 5′-levulinyl and 2′-tetrahydrofuranyl protection

E. Ohtsuka, S. Iwai, 1988 .

Flavin adenine dinucleotide chromophore charge controls the conformation of cyclobutane pyrimidine dimer photolyase α-helices.

E. Getzoff, J. Kennis, S. Iwai, 2014, Biochemistry.

Detection of distinct α-helical rearrangements of cyclobutane pyrimidine dimer photolyase upon substrate binding by Fourier transform infrared spectroscopy.

E. Getzoff, S. Iwai, K. Hitomi, 2013, Biochemistry.

Misreading of DNA templates containing 8-hydroxydeoxyguanosine at the modified base and at adjacent residues

H. Kasai, E. Ohtsuka, Y. Kuchino, 1987, Nature.

Spectroscopic analysis of the pyrimidine(6-4)pyrimidone photoproduct: insights into the (6-4) photolyase reaction.

S. Iwai, J. Yamamoto, Yoshiyuki Tanaka, 2009, Organic & biomolecular chemistry.

Quantitative analysis of isolated and clustered DNA damage induced by gamma-rays, carbon ion beams, and iron ion beams.

S. Iwai, H. Ide, Y. Furusawa, 2008, Journal of radiation research.

Studies of the interactions between Escherichia coli ribonuclease HI and its substrate.

Y. Uchiyama, E. Ohtsuka, Y. Ueno, 1994, Journal of molecular biology.

Synthesis and hybridization studies on two complementary nona(2'-O-methyl)ribonucleotides.

E. Ohtsuka, S. Iwai, A. Imura, 1987, Nucleic acids research.

Eukaryotic Class II Cyclobutane Pyrimidine Dimer Photolyase Structure Reveals Basis for Improved Ultraviolet Tolerance in Plants*

J. Tainer, E. Getzoff, S. Iwai, 2011, The Journal of Biological Chemistry.

Post-synthetic Modification of 3′ Terminus of RNA with Propargylamine: A Versatile Scaffold for RNA Labeling through Copper-catalyzed Azide-Alkyne Cycloaddition

S. Iwai, J. Yamamoto, Shohei Ebisuda, 2017 .

Bisnaphthalimidopropyl diaminodicyclohexylmethane induces DNA damage and repair instability in triple negative breast cancer cells via p21 expression.

S. Iwai, I. Kuraoka, G. Bermano, 2015, Chemico-biological interactions.

Analysis of ATP and AMP binding to a DNA aptamer and its imidazole-tethered derivatives by surface plasmon resonance.

K. Yamasaki, M. Miyagishi, S. Iwai, 2015, The Analyst.

A Molecular Basis for the Selective Recognition of 2-Hydroxy-dATP and 8-Oxo-dGTP by Human MTH1*

M. Shirakawa, M. Furuichi, Y. Nakabeppu, 2002, The Journal of Biological Chemistry.

Repair synthesis step involving ERCC1-XPF participates in DNA repair of the Top1-DNA damage complex.

S. Iwai, I. Kuraoka, A. Takedachi, 2015, Carcinogenesis.

Eukaryotic stress–induced mutagenesis is limited by a local control of translesion synthesis

S. Iwai, Vincent Pagès, Florencia Villafañez, 2022, Nucleic acids research.

Eukaryotic stress induced mutagenesis is limited by a local control of Translesion Synthesis

S. Iwai, Vincent Pagès, Florencia Villafañez, 2021 .

An RNA synthesis inhibition assay for detecting toxic substances using click chemistry.

S. Iwai, I. Kuraoka, Yuki Kametani, 2014, The Journal of toxicological sciences.

The Journal of Toxicological Sciences

S. Iwai, I. Kuraoka, Yuki Kametani, 2014 .

A non-isotopic assay uses bromouridine and RNA synthesis to detect DNA damage responses.

S. Iwai, I. Kuraoka, Mayu Hasegawa, 2010, Mutation research.

Structure and Function of T4 Endonuclease V

E. Ohtsuka, S. Iwai, 1994 .

Guanine- 5-carboxylcytosine base pairs mimic mismatches during DNA replication

J. Swenberg, F. Hanaoka, H. Koseki, 2014, Scientific Reports.

Molecular cloning and sequence determination of cDNAs for alpha subunits of the guanine nucleotide-binding proteins Gs, Gi, and Go from rat brain.

H. Kawasaki, K. Suzuki, T. Katada, 1986, Proceedings of the National Academy of Sciences of the United States of America.

DNA damage detection in nucleosomes involves DNA register shifting

D. Schübeler, H. Kurumizaka, K. Sugasawa, 2019, Nature.

Simultaneous Disruption of Two DNA Polymerases, Polη and Polζ, in Avian DT40 Cells Unmasks the Role of Polη in Cellular Response to Various DNA Lesions

J. Sale, F. Hanaoka, A. Lehmann, 2010, PLoS genetics.

Sequence-specific cleavage of RNA using chimeric DNA splints and RNase H.

E. Ohtsuka, S. Iwai, H. Inoue, 1988, Nucleic acids symposium series.

Analysis of CPD Ultraviolet Lesion Bypass in Chicken DT40 Cells: Polymerase η and PCNA Ubiquitylation Play Identical Roles

S. Iwai, D. Szüts, Á. Varga, 2012, PloS one.

Chemical synthesis and translesion replication of a cis-syn cyclobutane thymine-uracil dimer.

F. Hanaoka, S. Iwai, C. Masutani, 2004, Nucleic acids research.

REV1 restrains DNA polymerase ζ to ensure frame fidelity during translesion synthesis of UV photoproducts in vivo

J. Sale, S. Iwai, D. Szüts, 2008, Nucleic acids research.

DNA polymerase iota-dependent translesion replication of uracil containing cyclobutane pyrimidine dimers.

R. Woodgate, S. Iwai, A. Vaisman, 2006, DNA repair.

Effects of DNA lesions on the transcription reaction of mitochondrial RNA polymerase: implications for bypass RNA synthesis on oxidative DNA lesions.

D. Kang, S. Iwai, I. Kuraoka, 2013, Mutagenesis.

Simultaneous disruption of two DNA polymerases ,

J. Sale, A. Lehmann, K. Hirota, 2019 .

An in vitro method for detecting genetic toxicity based on inhibition of RNA synthesis by DNA lesions

S. Iwai, I. Kuraoka, Yuina Sonohara, 2015, Genes and Environment.

Characterization of a Y-Family DNA Polymerase eta from the Eukaryotic Thermophile Alvinella pompejana

J. Tainer, F. Hanaoka, David S. Shin, 2010, Journal of nucleic acids.

Stimulatory effect of an indirectly attached RNA helicase-recruiting sequence on the suppression of gene expression by antisense oligonucleotides.

K. Taira, M. Miyagishi, T. Futami, 2003, Antisense & nucleic acid drug development.

Effects of acetaldehyde-induced DNA lesions on DNA metabolism

S. Iwai, I. Kuraoka, Yuina Sonohara, 2020, Genes and Environment.

A method for detecting genetic toxicity using the RNA synthesis response to DNA damage.

S. Iwai, I. Kuraoka, Y. Morita, 2011, The Journal of toxicological sciences.

In vivo evidence for translesion synthesis by the replicative DNA polymerase δ

Mohiuddin, Z. Livneh, J. Sale, 2016, Nucleic acids research.

Roles of the polymerase and BRCT domains of Rev1 protein in translesion DNA synthesis in yeast in vivo.

S. Iwai, C. Otsuka, D. Loakes, 2005, Mutation research.

Excision of translesion synthesis errors orchestrates responses to helix-distorting DNA lesions

N. de Wind, G. Hendriks, Piya Temviriyanukul, 2015, The Journal of cell biology.

Binding of MutS mismatch repair protein to DNA containing UV photoproducts, "mismatched" opposite Watson--Crick and novel nucleotides, in different DNA sequence contexts.

J. Hays, F. Hanaoka, S. Iwai, 2005, DNA repair.

Chemical synthesis of oligodeoxyribonucleotides containing the Dewar valence isomer of the (6–4) photoproduct and their use in (6–4) photolyase studies

T. Todo, S. Iwai, K. Hitomi, 2006, Nucleic acids research.

Effect of sequence context on Polζ-dependent error-prone extension past (6-4) photoproducts.

N. de Wind, F. Hanaoka, S. Iwai, 2019, DNA repair.

Structural Changes of the Active Center during the Photoactivation of Xenopus (6-4) Photolyase.

Daichi Yamada, E. Getzoff, S. Iwai, 2016, Biochemistry.

Structural role of two histidines in the (6-4) photolyase reaction

Daichi Yamada, E. Getzoff, T. Todo, 2015, Biophysics and physicobiology.

Analysis of Structural Flexibility of Damaged DNA Using Thiol-Tethered Oligonucleotide Duplexes

S. Iwai, J. Yamamoto, M. Fujita, 2015, PloS one.

Strand breakage of a (6-4) photoproduct-containing DNA at neutral pH and its repair by the ERCC1-XPF protein complex.

S. Iwai, I. Kuraoka, J. Yamamoto, 2013, Organic & biomolecular chemistry.

Mechanism of the alkali degradation of (6-4) photoproduct-containing DNA.

S. Iwai, T. Mizukoshi, J. Yamamoto, 2012, Organic & biomolecular chemistry.

FTIR study of light-dependent activation and DNA repair processes of (6-4) photolyase.

E. Getzoff, T. Todo, S. Iwai, 2011, Biochemistry.

Endonuclease V from bacteriophage T4 interacts with its substrate in the minor groove.

E. Ohtsuka, N. Hori, H. Morioka, 1994, Biochemistry.

Nucleic Acids Research

E. Ohtsuka, S. Iwai, H. Inoue, 2016, Nucleic acids research.

Investigation of the Cyclobutane Pyrimidine Dimer (CPD) Photolyase DNA Recognition Mechanism by NMR Analyses*

T. Todo, K. Morikawa, T. Torizawa, 2004, Journal of Biological Chemistry.

Chemical Incorporation of Chain-Terminating Nucleoside Analogs as 3′-Blocking DNA Damage and Their Removal by Human ERCC1-XPF Endonuclease

K. Hirota, S. Iwai, I. Kuraoka, 2016, Molecules.

Substrate Assignment of the (6-4) Photolyase Reaction by FTIR Spectroscopy

Daichi Yamada, E. Getzoff, T. Todo, 2011 .

Nanosecond to submillisecond dynamics in dye-labeled single-stranded DNA, as revealed by ensemble measurements and photon statistics at single-molecule level.

S. Iwai, H. Miyasaka, T. Kaji, 2009, The journal of physical chemistry. B.

Sequence‐dependent hydrolysis of RNA using modified oligonucleotide splints and RNase H

E. Ohtsuka, S. Iwai, H. Inoue, 1987, Nucleic acids symposium series.

Solid-phase synthesis of protected oligonucleotide blocks : Applications to block condensation on a polymer support and synthesis of a 3'-modified oligonucleotides

E. Ohtsuka, M. Ikehara, S. Iwai, 1987 .

Catalysis by Escherichia coli ribonuclease HI is facilitated by a phosphate group of the substrate.

S. Kanaya, M. Haruki, S. Iwai, 2000, Biochemistry.

SOLUTION STRUCTURE OF AN RNA 2'-O-METHYLATED RNA DUPLEX CONTAINING AN RNA/DNA HYBRID SEGMENT AT THE CENTER, NMR, MINIMIZED AVERAGE STRUCTURE

E. Ohtsuka, S. Iwai, Haruki Nakamura, 1997 .

A novel Nudix hydrolase for oxidized purine nucleoside triphosphates encoded by ORFYLR151c (PCD1 gene) in Saccharomyces cerevisiae.

Y. Nakabeppu, T. Nunoshiba, S. Iwai, 2004, Nucleic acids research.

Repriming by PrimPol is critical for DNA replication restart downstream of lesions and chain-terminating nucleosides

A. Doherty, K. Hirota, Kaori Kobayashi, 2016, Cell cycle.

Solution structure of an RNA.2'-O-methylated RNA hybrid duplex containing an RNA.DNA hybrid segment at the center.

H. Nakamura, E. Ohtsuka, S. Iwai, 1997, Biochemistry.

Role of the Mg2+ ion in the Escherichia coli ribonuclease HI reaction.

Y. Uchiyama, E. Ohtsuka, Y. Ueno, 1994, Journal of biochemistry.

FEN1 participates in repair of the 5'-phosphotyrosyl terminus of DNA single-strand breaks.

S. Iwai, I. Kuraoka, Kiyoji Tanaka, 2016, Carcinogenesis.

Misinsertion and bypass of thymine–thymine dimers by human DNA polymerase ι

J P McDonald, E. G. Frank, R. Woodgate, 2000, The EMBO journal.

Human replicative DNA polymerase δ can bypass T‐T (6‐4) ultraviolet photoproducts on template strands

K. Hirota, S. Iwai, T. Tsurimoto, 2010, Genes to cells : devoted to molecular & cellular mechanisms.

Palm mutants in DNA polymerases alpha and eta alter DNA replication fidelity and translesion activity.

E. Kool, Siripan Limsirichaikul, F. Hanaoka, 2004, Molecular and cellular biology.

5 – Chemical Synthesis of RNA

E. Ohtsuka, S. Iwai, 1987 .

Role of tryptophan residues in the recognition of mutagenic oxidized nucleotides by human antimutator MTH1 protein.

M. Shirakawa, Y. Nakabeppu, M. Sekiguchi, 2002, Journal of molecular biology.

The intricate structural chemistry of base excision repair machinery: implications for DNA damage recognition, removal, and repair.

J. Tainer, S. Iwai, K. Hitomi, 2007, DNA repair.

Advanced Organic Chemistry

S. Iwai, Y. Tobe, Y. Imada, 2012 .

Large scale synthesis of oligoribonucleotides on a solid support: synthesis of a catalytic RNA duplex

E. Ohtsuka, S. Iwai, Toshiro Sasaki, 1990 .

5'-Levulinyl and 2'-tetrahydrofuranyl protection for the synthesis of oligoribonucleotides by the phosphoramidite approach.

E. Ohtsuka, S. Iwai, 1988, Nucleic acids research.

The GT to GC single nucleotide polymorphism at the beginning of an alternative exon 2C of human MTH1 gene confers an amino terminal extension that functions as a mitochondrial targeting signal

T. Hara, M. Furuichi, Y. Nakabeppu, 2006, Journal of molecular medicine.

Blockage of RNA polymerase II at a cyclobutane pyrimidine dimer and 6-4 photoproduct.

H. Handa, E. Kobatake, S. Iwai, 2004, Biochemical and biophysical research communications.

Atomic model of a pyrimidine dimer excision repair enzyme complexed with a dna substrate: Structural basis for damaged DNA recognition

Shigenori Iwai, Mariko Ariyoshi, D. Vassylyev, 1995, Cell.

An assay to detect DNA-damaging agents that induce nucleotide excision-repairable DNA lesions in living human cells.

S. Iwai, I. Kuraoka, Reine Takatsuka, 2017, Mutation research.

ATP‐dependent chromatin remodeling facilitates nucleotide excision repair of UV‐induced DNA lesions in synthetic dinucleosomes

Y. Kaneda, F. Hanaoka, S. Iwai, 2001, The EMBO journal.

DDB1-DDB2 (Xeroderma Pigmentosum Group E) Protein Complex Recognizes a Cyclobutane Pyrimidine Dimer, Mismatches, Apurinic/Apyrimidinic Sites, and Compound Lesions in DNA*

R. Wood, S. Iwai, Birgitte Ø. Wittschieben, 2005, Journal of Biological Chemistry.

Photoaffinity labeling of T4 endonuclease V with a substrate containing a phenyldiazirine derivative.

E. Ohtsuka, N. Hori, S. Iwai, 1992, The Journal of biological chemistry.

Chemical Synthesis of Oligonucleotides Containing Damaged Bases for Biological Studies

S. Iwai, 2006, Nucleosides, nucleotides & nucleic acids.

Synthesis of a gene for human growth hormone and its expression in Escherichia coli.

E. Ohtsuka, M. Ikehara, S. Miyamoto, 1984, Proceedings of the National Academy of Sciences of the United States of America.

Centrin 2 Stimulates Nucleotide Excision Repair by Interacting with Xeroderma Pigmentosum Group C Protein

K. Sugasawa, F. Hanaoka, S. Iwai, 2005, Molecular and Cellular Biology.

Facile preparation of a fluorescent probe to detect the cellular ability of nucleotide excision repair.

S. Iwai, I. Kuraoka, Hana Tawarahara, 2017, Analytical biochemistry.

Fluorescence detection of cellular nucleotide excision repair of damaged DNA

K. Sugasawa, S. Iwai, I. Kuraoka, 2014, Scientific Reports.

Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4): an archaeal DinB-like DNA polymerase with lesion-bypass properties akin to eukaryotic poleta.

R. Woodgate, F. Hanaoka, S. Iwai, 2001, Nucleic acids research.

A cyclobutane thymine–N4-methylcytosine dimer is resistant to hydrolysis but strongly blocks DNA synthesis

F. Hanaoka, S. Iwai, C. Masutani, 2013, Nucleic acids research.

Photosensitized [2 + 2] cycloaddition of N-acetylated cytosine affords stereoselective formation of cyclobutane pyrimidine dimer

F. Hanaoka, S. Iwai, C. Masutani, 2010, Nucleic acids research.

How does RNase H recognize a DNA.RNA hybrid?

H. Nakamura, K. Morikawa, S. Kanaya, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Synthesis and Thermal Stability of Dodecadeoxyribonucleotides Containing Deoxyinosine Pairing with Four Major Bases

E. Ohtsuka, S. Iwai, Y. Kawase, 1989 .

Studies on nucleic acid interactions. I. Stabilities of mini-duplexes (dG2A4XA4G2-dC2T4YT4C2) and self-complementary d(GGGAAXYTTCCC) containing deoxyinosine and other mismatched bases.

E. Ohtsuka, S. Iwai, Y. Kawase, 1986, Nucleic acids research.

Deoxyribonucleic Acids and Related Compounds. VIII. Solid-Phase Synthesis of Deoxyribooligonucleotides with 3'-Modification by Elongation in the 3'-Direction

E. Ohtsuka, M. Ikehara, S. Iwai, 1984 .

Effects of 5',8-cyclodeoxyadenosine triphosphates on DNA synthesis.

P. J. Brooks, S. Iwai, I. Kuraoka, 2012, Chemical research in toxicology.

Human Mitochondrial DNA Polymerase Metal Dependent UV Lesion Bypassing Ability

S. Iwai, L. Brieba, Y. Yin, 2022, Frontiers in Molecular Biosciences.

Decoy approach using RNA-DNA chimera oligonucleotides to inhibit the regulatory function of human immunodeficiency virus type 1 Rev protein

K. Ikuta, K. Fujinaga, S. Iwai, 1997, Antimicrobial agents and chemotherapy.

Role of the carbonyl group of the (6-4) photoproduct in the (6-4) photolyase reaction.

E. Getzoff, S. Iwai, K. Hitomi, 2009, Biochemistry.

Functional motifs in the (6-4) photolyase crystal structure make a comparative framework for DNA repair photolyases and clock cryptochromes

J. Tainer, E. Getzoff, S. Panda, 2009, Proceedings of the National Academy of Sciences.

Role of Two Histidines in the (6-4) Photolyase Reaction*

T. Todo, T. Ishikawa, S. Iwai, 2001, The Journal of Biological Chemistry.

Cleavage of specific sites of RNA by designed ribozymes

E. Ohtsuka, S. Iwai, M. Koizumi, 1988, FEBS letters.

Identification and Characterization of an Intermediate in the Alkali Degradation of (6-4) Photoproduct-containing DNA*

T. Ohtsuki, F. Hanaoka, S. Iwai, 2003, Journal of Biological Chemistry.

Mechanisms of accurate translesion synthesis by human DNA polymerase η

F. Hanaoka, S. Iwai, C. Masutani, 2000, The EMBO journal.

Synthesis and characterization of a substrate for T4 endonuclease V containing a phosphorodithioate linkage at the thymine dimer site.

E. Ohtsuka, S. Iwai, T. Murata, 1990, Nucleic acids research.

A new solid-phase synthesis of oligoribonucleotides by the phosphoro-p-anisidate method using tetrahydrofuranyl protection of 2'-hydroxyl groups.

E. Ohtsuka, S. Iwai, H. Inoue, 1987, Nucleic acids research.

Synthesis and characterization of oligonucleotides containing 2′-fluorinated thymidine glycol as inhibitors of the endonuclease III reaction

Yusuke Doi, Shigenori Iwai, John A. Tainer, 2006, Nucleic acids research.

Plant organellar DNA polymerases bypass Thymine Glycol using two conserved lysine residues.

S. Iwai, L. Brieba, J. Yamamoto, 2020, The Biochemical journal.

Fate of DNA replication fork encountering a single DNA lesion during oriC plasmid DNA replication in vitro

H. Maki, T. Katayama, M. Hidaka, 2003, Genes to cells : devoted to molecular & cellular mechanisms.

Complementation of defective translesion synthesis and UV light sensitivity in xeroderma pigmentosum variant cells by human and mouse DNA polymerase

Ayumi Yamada, Chikahide Masutani, Shigenori Iwai, 2000, Nucleic Acids Res..

DNA binding properties of human DNA polymerase η: implications for fidelity and polymerase switching of translesion synthesis

F. Hanaoka, S. Iwai, C. Masutani, 2004, Genes to cells : devoted to molecular & cellular mechanisms.

Xeroderma pigmentosum variant (XP‐V) correcting protein from HeLa cells has a thymine dimer bypass DNA polymerase activity

F. Hanaoka, S. Iwai, C. Masutani, 1999, The EMBO journal.

Structure of Human MTH1, a Nudix Family Hydrolase That Selectively Degrades Oxidized Purine Nucleoside Triphosphates*

M. Shirakawa, Y. Yamagata, M. Furuichi, 2004, Journal of Biological Chemistry.

High‐efficiency bypass of DNA damage by human DNA polymerase Q

I. Bahar, Lee-Wei Yang, R. Wood, 2004, The EMBO journal.

Sequence context-dependent replication of DNA templates containing UV-induced lesions by human DNA polymerase iota.

E. G. Frank, R. Woodgate, F. Hanaoka, 2003, DNA repair.

An Oxidized Purine Nucleoside Triphosphatase, MTH1, Suppresses Cell Death Caused by Oxidative Stress*

M. Ohno, K. Sakumi, M. Furuichi, 2003, Journal of Biological Chemistry.

Construction of a series of several self‐cleaving RNA duplexes using synthetic 21‐mers

E. Ohtsuka, S. Iwai, M. Koizumi, 1988, FEBS letters.

UV-Induced Ubiquitylation of XPC Protein Mediated by UV-DDB-Ubiquitin Ligase Complex

Keiji Tanaka, K. Sugasawa, G. Chu, 2005, Cell.

Synthesis and expression of a synthetic gene for the activated human c-Ha-ras protein.

E. Ohtsuka, M. Ikehara, S. Iwai, 1986, Japanese journal of cancer research : Gann.

Molecular analysis of zebrafish photolyase/cryptochrome family: two types of cryptochromes present in zebrafish

T. Todo, H. Toh, H. Daiyasu, 2000, Genes to cells : devoted to molecular & cellular mechanisms.

Two-step recognition of DNA damage for mammalian nucleotide excision repair: Directional binding of the XPC complex and DNA strand scanning.

K. Sugasawa, F. Hanaoka, S. Iwai, 2009, Molecular cell.

Repair of apurinic/apyrimidinic sites by UV damage endonuclease; a repair protein for UV and oxidative damage.

A. Yasui, S. Iwai, S. Kanno, 1999, Nucleic acids research.

The Gly-952 Residue of Saccharomyces cerevisiae DNA Polymerase α Is Important in Discriminating Correct Deoxyribonucleotides from Incorrect Ones*

Siripan Limsirichaikul, S. Yoshida, M. Ogawa, 2003, Journal of Biological Chemistry.

Arabidopsis thaliana endonuclease V is a ribonuclease specific for inosine-containing single-stranded RNA

S. Iwai, I. Kuraoka, N. Shioi, 2021, Open Biology.

Inosine‐specific ribonuclease activity of natural variants of human endonuclease V

S. Iwai, I. Kuraoka, J. I. Kim, 2016, FEBS letters.

Human endonuclease V is a ribonuclease specific for inosine-containing RNA

K. Nishikura, S. Iwai, I. Kuraoka, 2013, Nature Communications.

Biochemical properties and base excision repair complex formation of apurinic/apyrimidinic endonuclease from Pyrococcus furiosus

Y. Ishino, T. Shirai, S. Iwai, 2009, Nucleic acids research.

Chlorella virus pyrimidine dimer glycosylase and Escherichia coli endonucleases IV and V have incision activity on 2,2,4-triamino-5(2H)-oxazolone

S. Iwai, H. Miyazawa, K. Kino, 2015, Genes and Environment.

Molecular Basis of Substrate Recognition of Endonuclease Q from the Euryarchaeon Pyrococcus furiosus

S. Iwai, Miyako Shiraishi, 2019, Journal of bacteriology.

Endonuclease V from the archaeon Thermococcus kodakarensis is an inosine-specific ribonuclease.

S. Iwai, Miyako Shiraishi, Michihi Hidaka, 2021, Bioscience, biotechnology and biochemistry.

Differential Specificity of Human and Escherichia coli Endonuclease III and VIII Homologues for Oxidative Base Lesions*

F. Hanaoka, S. Iwai, H. Ide, 2004, Journal of Biological Chemistry.

Chlorella virus pyrimidine dimer glycosylase and Escherichia coli endonucleases IV and V have incision activity on 2,2,4-triamino-5(2H)-oxazolone

S. Iwai, H. Miyazawa, K. Kino, 2015, Genes and Environment.

Mutational analysis of Thermococcus kodakarensis Endonuclease III reveals the roles of evolutionarily conserved residues.

S. Iwai, J. Yamamoto, Miyako Shiraishi, 2020, DNA repair.

A Role for DNA Polymerase β in Mutagenic UV Lesion Bypass*

F. Hanaoka, S. Iwai, C. Cazaux, 2002, The Journal of Biological Chemistry.

Human DNA Polymerase N (POLN) Is a Low Fidelity Enzyme Capable of Error-free Bypass of 5S-Thymine Glycol*

R. Wood, K. Takata, S. Iwai, 2006, Journal of Biological Chemistry.

Translesion synthesis by human DNA polymerase eta across thymine glycol lesions.

F. Hanaoka, S. Iwai, C. Masutani, 2002, Biochemistry.

The Molecular Basis of Crl4(Ddb2/Csa) Ubiquitin Ligase Architecture, Targeting, and Activation.

Shigenori Iwai, Nicolas H. Thomä, Eric S. Fischer, 2011 .

Palm Mutants in DNA Polymerases α and η Alter DNA Replication Fidelity and Translesion Activity

E. Kool, Siripan Limsirichaikul, F. Hanaoka, 2004, Molecular and Cellular Biology.

Preferential cis–syn thymine dimer bypass by DNA polymerase η occurs with biased fidelity

T. Kunkel, F. Hanaoka, S. Iwai, 2004, Nature.

Error-prone bypass of certain DNA lesions by the human DNA polymerase kappa.

F. Hanaoka, S. Iwai, C. Masutani, 2000, Genes & development.

The oxidative DNA glycosylases of Mycobacterium tuberculosis exhibit different substrate preferences from their Escherichia coli counterparts.

Xiaobei Zhao, J. Bond, M. Dizdaroglu, 2010, DNA repair.

Human thymine DNA glycosylase (TDG) and methyl-CpG-binding protein 4 (MBD4) excise thymine glycol (Tg) from a Tg:G mispair.

G. Pfeifer, T. O'Connor, S. Iwai, 2003, Nucleic acids research.

Reaction mechanism of T4 endonuclease V determined by analysis using modified oligonucleotide duplexes.

E. Ohtsuka, S. Iwai, Y. Shimada, 1995, Biochemistry.

Use of yeast transformation by oligonucleotides to study DNA lesion bypass in vivo.

V. Noskov, S. Iwai, C. Otsuka, 2002, Mutation research.

Generic expansion of the substrate spectrum of a DNA polymerase by directed evolution

R. Woodgate, F. Ghadessy, S. Iwai, 2004, Nature Biotechnology.

The (6-4) photoproduct of thymine-thymine induces targeted substitution mutations in mammalian cells.

S. Iwai, H. Kamiya, H. Kasai, 1998, Nucleic acids research.

Crystal structure of the DNA repair enzyme ultraviolet damage endonuclease.

J. Abrahams, N. Pannu, S. Iwai, 2007, Structure.

Identification of the amino acid residues involved in an active site of Escherichia coli ribonuclease H by site-directed mutagenesis.

S. Kanaya, E. Ohtsuka, M. Ikehara, 1990, The Journal of biological chemistry.

Light-induced conformational change and product release in DNA repair by (6-4) photolyase.

E. Getzoff, T. Todo, S. Iwai, 2011, Journal of the American Chemical Society.

Bacterial cryptochrome and photolyase: characterization of two photolyase-like genes of Synechocystis sp. PCC6803.

T. Todo, H. Toh, H. Daiyasu, 2000, Nucleic acids research.

Design of RNA enzymes distinguishing a single base mutation in RNA.

E. Ohtsuka, S. Iwai, H. Kamiya, 1989, Nucleic acids research.

Hydrogen-bonding contacts in the major groove are required for human immunodeficiency virus type-1 tat protein recognition of TAR RNA.

J Grasby, J. Karn, J. Grasby, 1993, Journal of molecular biology.

Recognition of the high affinity binding site in rev-response element RNA by the human immunodeficiency virus type-1 rev protein.

J. Karn, S. Iwai, D. Mann, 1992, Nucleic acids research.

Cloning and characterization of a gene (UVR3) required for photorepair of 6-4 photoproducts in Arabidopsis thaliana.

T. Todo, S. Iwai, K. Hitomi, 1998, Nucleic acids research.

Interaction of T4 Endonuclease V with DNA

K. Morikawa, S. Iwai, Bong‐Jin Lee, 2003, Journal of Biological Chemistry.

Abacavir, an anti–HIV-1 drug, targets TDP1-deficient adult T cell leukemia

N. Kadowaki, K. Hirota, S. Iwai, 2015, Science Advances.

Xeroderma pigmentosum variant: from a human genetic disorder to a novel DNA polymerase.

T. Eki, F. Hanaoka, S. Iwai, 2000, Cold Spring Harbor symposia on quantitative biology.

Mechanism and regulation of DNA damage recognition in nucleotide excision repair

W. Sakai, K. Sugasawa, S. Iwai, 2019, Genes and Environment.

NMR Study of Repair Mechanism of DNA Photolyase by FAD-induced Paramagnetic Relaxation Enhancement*

T. Torizawa, I. Shimada, S. Kuramitsu, 2004, Journal of Biological Chemistry.

Recognition of 2′‐hydroxyl groups by Escherichia coli ribonuclease HI

E. Ohtsuka, S. Iwai, S. Kataoka, 1995, FEBS letters.

Distinct Function of Conserved Amino Acids in the Fingers of Saccharomyces cerevisiae DNA Polymerase α*

Siripan Limsirichaikul, S. Yoshida, M. Ogawa, 2003, Journal of Biological Chemistry.

The dominant role of proofreading exonuclease activity of replicative polymerase ε in cellular tolerance to cytarabine (Ara-C)

Y. Pommier, J. Sale, K. Hirota, 2017, Oncotarget.

Acetaldehyde induces NER repairable mutagenic DNA lesions.

S. Iwai, C. Masutani, I. Kuraoka, 2021, Carcinogenesis.

UV damage endonuclease employs a novel dual-dinucleotide flipping mechanism to recognize different DNA lesions

Shigenori Iwai, Navraj S. Pannu, N. Pannu, 2012, Nucleic acids research.

Identification of human MutY homolog (hMYH) as a repair enzyme for 2-hydroxyadenine in DNA and detection of multiple forms of hMYH located in nuclei and mitochondria

Y. Nakabeppu, K. Nishioka, S. Iwai, 2000, Nucleic acids research.

Nuclear magnetic resonance study of the interaction of T4 endonuclease V with DNA.

Y. Kyōgoku, K. Morikawa, E. Ohtsuka, 1994, Biochemistry.

Synthesis and thermodynamic studies of oligonucleotides containing the two isomers of thymine glycol.

S. Iwai, 2001, Chemistry.

Nucleosomal structure of undamaged DNA regions suppresses the non-specific DNA binding of the XPC complex.

Shigenori Iwai, Fumio Hanaoka, Takeshi Yasuda, 2005, DNA repair.

Binding and Catalytic Properties of Xenopus (6-4) Photolyase*

T. Todo, M. Ikenaga, S. Iwai, 1997, The Journal of Biological Chemistry.

Structural study of DNA duplexes containing the (6-4) photoproduct by fluorescence resonance energy transfer.

T. Kodama, T. Furuno, M. Nakanishi, 2001, Nucleic acids research.

Biochemical evolution of DNA polymerase eta: properties of plant, human, and yeast proteins.

J. Hays, S. Iwai, P. Hoffman, 2008, Biochemistry.

Human Nei‐like protein NEIL3 has AP lyase activity specific for single‐stranded DNA and confers oxidative stress resistance in Escherichia coli mutant

A. Yasui, Kumiko Kobayashi, S. Iwai, 2009, Genes to cells : devoted to molecular & cellular mechanisms.

Structural analysis of the human Rad51 protein-DNA complex filament by tryptophan fluorescence scanning analysis: transmission of allosteric effects between ATP binding and DNA binding.

H. Kurumizaka, S. Iwai, Y. Takizawa, 2008, Journal of molecular biology.

DNA polymerases η and κ are responsible for error-free translesion DNA synthesis activity over a cis–syn thymine dimer in Xenopus laevis oocyte extracts

H. Maki, F. Hanaoka, S. Iwai, 2005 .

Expression of a synthetic human growth hormone gene in yeast.

E. Ohtsuka, M. Ikehara, S. Iwai, 1985, Gene.

Limited solvation of an electron donating tryptophan stabilizes a photoinduced charge-separated state in plant (6–4) photolyase

Hirotaka Kitoh-Nishioka, S. Iwai, J. Yamamoto, 2022, Scientific Reports.

Acetaldehyde forms covalent GG intrastrand crosslinks in DNA

S. Iwai, T. Matsuda, I. Kuraoka, 2019, Scientific Reports.

Molecular analyses of an unusual translesion DNA polymerase from Methanosarcina acetivorans C2A.

S. Koike, R. Mackie, Y. Ishino, 2010, Journal of molecular biology.

Novel plasmids for the fluorescence-based evaluation of DNA mismatch repair in human cells.

M. Hidaka, R. Fujikane, S. Iwai, 2022, Mutation research.

Fluorescence detection of DNA mismatch repair in human cells

S. Iwai, I. Kuraoka, J. Yamamoto, 2018, Scientific Reports.

DNA polymerases eta and kappa are responsible for error-free translesion DNA synthesis activity over a cis-syn thymine dimer in Xenopus laevis oocyte extracts.

H. Maki, F. Hanaoka, S. Iwai, 2005, DNA repair.

Novel mechanisms for the removal of strong replication-blocking HMCES- and thiazolidine-DNA adducts in humans.

S. Iwai, C. Masutani, Y. Masuda, 2023, Nucleic acids research.

Repair of the (6-4) photoproduct by DNA photolyase requires two photons.

S. Iwai, J. Yamamoto, K. Brettel, 2013, Angewandte Chemie.

Coulomb and CH–π interactions in (6–4) photolyase–DNA complex dominate DNA binding and repair abilities

T. Todo, R. Harada, Tomoko Ishikawa-Fujiwara, 2018, Nucleic acids research.

Loss of Fourth Electron-Transferring Tryptophan in Animal (6-4) Photolyase Impairs DNA Repair Activity in Bacterial Cells.

S. Iwai, J. Yamamoto, Y. Hosokawa, 2017, Biochemistry.

Implications of a Water Molecule for Photoactivation of Plant (6-4) Photolyase.

S. Iwai, J. Yamamoto, Ryuma Sato, 2019, The journal of physical chemistry. B.

Functional Conversion of CPD and (6-4) Photolyases by Mutation.

Daichi Yamada, E. Getzoff, T. Todo, 2016, Biochemistry.

FTIR study of CPD photolyase with substrate in single strand DNA

E. Getzoff, S. Iwai, K. Hitomi, 2015, Biophysics.

Discovery and functional analysis of a 4th electron-transferring tryptophan conserved exclusively in animal cryptochromes and (6-4) photolyases.

S. Iwai, J. Yamamoto, K. Brettel, 2015, Chemical communications.

Key interactions with deazariboflavin cofactor for light-driven energy transfer in Xenopus (6–4) photolyase

S. Iwai, J. Yamamoto, R. K. Verma, 2021, Photochemical & Photobiological Sciences.

Monitoring Repair of UV-Induced 6-4-Photoproducts with a Purified DDB2 Protein Complex

Mathew R Schnorenberg, M. Dreze, D. Fisher, 2014, PloS one.

Structural basis of pyrimidine-pyrimidone (6–4) photoproduct recognition by UV-DDB in the nucleosome

H. Kurumizaka, A. Osakabe, K. Sugasawa, 2015, Scientific Reports.

Crystal structure of the nucleosome containing ultraviolet light-induced cyclobutane pyrimidine dimer.

H. Kurumizaka, A. Osakabe, K. Sugasawa, 2016, Biochemical and biophysical research communications.

Functional regulation of the DNA damage-recognition factor DDB2 by ubiquitination and interaction with xeroderma pigmentosum group C protein

W. Sakai, K. Sugasawa, F. Hanaoka, 2015, Nucleic acids research.

DNA damage detection in nucleosomes involves DNA register shifting

D. Schübeler, H. Kurumizaka, K. Sugasawa, 2019, Nature.

Mutagenic and Nonmutagenic Bypass of DNA Lesions byDrosophila DNA Polymerases dpolη and dpolι *

H. Iwasaki, T. Todo, R. Ueda, 2001, The Journal of Biological Chemistry.

Cyclobutane thymine dimers in a ras proto-oncogene hot spot activate the gene by point mutation.

F. Hanaoka, A. Matsukage, E. Ohtsuka, 1993, Nucleic acids research.

Enhanced DNA repair by DNA photolyase bearing an artificial light-harvesting chromophore

S. Iwai, J. Yamamoto, Ryuma Sato, 2020, Nucleic acids research.

A role for DNA polymerase beta in mutagenic UV lesion bypass.

F. Hanaoka, S. Iwai, C. Cazaux, 2002, Journal of Biological Chemistry.

Inhibiting guanine oxidation and enhancing the excess-electron-transfer efficiency of a pyrene-modified oligonucleotide by introducing an electron-donating group on pyrene.

T. Takagi, S. Iwai, S. Obika, 2019, Chemical communications.

Interaction of the basic protrusion of Escherichia coli ribonuclease HI with its substrate.

A. Kidera, H. Nakamura, S. Kanaya, 1996, Journal of Molecular Biology.

An in vitro method for detecting genetic toxicity based on inhibition of RNA synthesis by DNA lesions

S. Iwai, I. Kuraoka, Yuina Sonohara, 2015, Genes and Environment.

Solution Strucutres of DNA duplexes containing a DNA x RNA hybrid region, d(GG)r(AGAU)d(GAC) x d(GTCATCTCC) and d(GGAGA)r(UGAC) x d(GTCATCTCC).

H. Nakamura, Y. Kyōgoku, E. Ohtsuka, 1996, Biochemistry.

Binding of nucleic acids to E. coli RNase HI observed by NMR and CD spectroscopy.

H. Nakamura, E. Ohtsuka, M. Ikehara, 1993, Nucleic acids research.

Xeroderma pigmentosum group F protein binds to Eg5 and is required for proper mitosis: implications for XP‐F and XFE

S. Iwai, I. Kuraoka, Kiyoji Tanaka, 2012, Genes to cells : devoted to molecular & cellular mechanisms.

DNA polymerase iota and related rad30-like enzymes.

E. G. Frank, R. Woodgate, F. Hanaoka, 2001, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

DNA Damage, Mutagenesis, and DNA Repair

S. Broyde, C. Kisker, S. Iwai, 2010, Journal of Nucleic Acids.

STUDIES ON THE CHEMICAL SYNTHESIS OF OLIGONUCLEOTIDES CONTAINING THE (6-4)PHOTOPRODUCT OF THYMINE-CYTOSINE AND ITS REPAIR BY (6-4) PHOTOLYASE

T. Todo, S. Iwai, T. Mizukoshi, 1998 .

Repair of topoisomerase 1–induced DNA damage by tyrosyl-DNA phosphodiesterase 2 (TDP2) is dependent on its magnesium binding

S. Iwai, N. Shimizu, M. Tsuda, 2023, The Journal of biological chemistry.

A formamidopyrimidine derivative from the deoxyguanosine adduct produced by food contaminant acrylamide induces DNA replication block and mutagenesis

K. Sugasawa, F. Hanaoka, T. Shirai, 2023, The Journal of biological chemistry.

Fluorescent probes for the analysis of DNA strand scission in base excision repair

K. Sugasawa, S. Iwai, I. Kuraoka, 2010, Nucleic acids research.

High-efficiency bypass of DNA damage by human DNA polymerase Q.

I. Bahar, Lee-Wei Yang, R. Wood, 2004, The EMBO journal.

Cyclobutane thymine dimers ina rasproto-oncogene hot spotactivate thegenebypoint mutation

S. Iwai, H. Kamiya, C. Masutani, 1993 .

Kobe University Repository : Kernel タイトル Tit le DNA damage detect ion in nucleosomes involves DNA register shift

D. Schübeler, H. Kurumizaka, K. Sugasawa, 2020 .

Fluorescence detection of DNA mismatch repair in human cells

S. Iwai, I. Kuraoka, J. Yamamoto, 2018, Scientific Reports.

High‐efficiency bypass of DNA damage by human DNA polymerase Q

I. Bahar, S. Iwai, C. Masutani, 2004, The EMBO journal.

Abacavir, an anti–HIV-1 drug, targets TDP1-deficient adult T cell leukemia

N. Kadowaki, K. Hirota, S. Iwai, 2015, Science Advances.

Synthesis of Wobble Pairing Oligoribonucleotides

E. Ohtsuka, S. Iwai, M. Koizumi, 1989 .

Studies on nucleic acid interactions. I. Stabilities of mini-duplexes (dG2A4XA4G2-dC2T4YT4C2) and self-complementary d(GGGAAXYTTCCC) containing deoxyinosine and other mismatched bases.

E. Ohtsuka, S. Iwai, Y. Kawase, 1986, Nucleic acids research.

Mechanism of the alkali degradation of (6-4) photoproduct-containing DNA.

S. Iwai, T. Mizukoshi, Aki Inase, 2012, Organic & biomolecular chemistry.

The oxidative DNA glycosylases of Mycobacterium tuberculosis exhibit different substrate preferences from their Escherichia coli counterparts.

Xiaobei Zhao, J. Bond, M. Dizdaroglu, 2010, DNA repair.

Preferential formation of (5S,6R)-thymine glycol for oligodeoxyribonucleotide synthesis and analysis of drug binding to thymine glycol-containing DNA

S. Yoshikawa, S. Iwai, Y. Kawasaki, 2006, Nucleic acids research.

Electronic Supplementary Information Discovery and Functional Analysis of a 4 Th Electron-transferring Tryptophan Conserved Exclusively in Animal Cryptochromes and (6-4) Photolyases

S. Iwai, K. Brettel, P. Müller, 2022 .