P. Storici

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From protein structure to function via single crystal optical spectroscopy

Paola Storici, Andrea Mozzarelli, Luca Ronda, 2015, Front. Mol. Biosci..

Emerging SARS-CoV-2 mutation hot spots include a novel RNA-dependent-RNA polymerase variant

M. Ciccozzi, R. Gallo, P. Storici, 2020, Journal of Translational Medicine.

A novel cDNA sequence encoding a pig leukocyte antimicrobial peptide with a cathelin-like pro-sequence.

P. Storici, M. Zanetti, 1993, Biochemical and biophysical research communications.

Baculovirus-driven protein expression in insect cells: A benchmarking study.

L. Lua, T. Bergbrede, P. Storici, 2018, Journal of structural biology.

PHA-739358, a potent inhibitor of Aurora kinases with a selective target inhibition profile relevant to cancer

Paola Storici, Cristina Alli, Maurizio Rocchetti, 2007, Molecular Cancer Therapeutics.

A Blueprint for High Affinity SARS-CoV-2 Mpro Inhibitors from Activity-Based Compound Library Screening Guided by Analysis of Protein Dynamics

R. Wade, E. Lindahl, F. Spyrakis, 2020, bioRxiv.

Identification of small-molecule EGFR allosteric inhibitors by high-throughput docking.

G. Rastelli, M. Broggini, P. Storici, 2018, Future medicinal chemistry.

Combination of SAXS and Protein Painting Discloses the Three-Dimensional Organization of the Bacterial Cysteine Synthase Complex, a Potential Target for Enhancers of Antibiotic Action

A. Mozzarelli, L. Ronda, S. Bettati, 2019, International journal of molecular sciences.

Structure–Activity Relationships of Hexahydrocyclopenta[c]quinoline Derivatives as Allosteric Inhibitors of CDK2 and EGFR

L. Lo Presti, G. Rastelli, M. Broggini, 2018, ChemMedChem.

PHA-680632, a Novel Aurora Kinase Inhibitor with Potent Antitumoral Activity

D. Ballinari, V. Croci, P. Cappella, 2006, Clinical Cancer Research.

Investigational Studies on a Hit Compound Cyclopropane-Carboxylic Acid Derivative Targeting O-Acetylserine Sulfhydrylase as a Colistin Adjuvant.

A. Mozzarelli, S. Bettati, Marialaura Marchetti, 2021, ACS infectious diseases.

Identification of inhibitors of SARS-CoV-2 3CL-Pro enzymatic activity using a small molecule in-vitro repurposing screen

F. Musiani, Daniela Iaconis, V. Summa, 2020, bioRxiv.

Comparative analysis of fusion tags used to functionalize recombinant antibodies.

A. de Marco, P. Storici, B. Medagli, 2020, Protein expression and purification.

Mechanistic crystallography. Mechanism of inactivation of gamma-aminobutyric acid aminotransferase by (1R,3S,4S)-3-amino-4-fluorocyclopentane-1-carboxylic acid as elucidated by crystallography.

P. Storici, R. Silverman, Tilman Schirmer, 2004, Biochemistry.

Crystal structure of human ornithine aminotransferase complexed with the highly specific and potent inhibitor 5-fluoromethylornithine.

G. Capitani, J. Jansonius, P. Storici, 1999, Journal of molecular biology.

Crystal Structure of GABA-Aminotransferase, a Target for Antiepileptic Drug Therapy†

G. Capitani, J. Jansonius, P. Storici, 1999 .

A cDNA derived from pig bone marrow cells predicts a sequence identical to the intestinal antibacterial peptide PR-39.

P. Storici, M. Zanetti, 1993, Biochemical and biophysical research communications.

Molecular cloning and chemical synthesis of a novel antibacterial peptide derived from pig myeloid cells.

P. Storici, R. Gennaro, A. Tossi, 1994, The Journal of biological chemistry.

The cDNA of the neutrophil antibiotic Bac5 predicts a pro-sequence homologous to a cysteine proteinase inhibitor that is common to other neutrophil antibiotics.

G. Del Sal, C. Schneider, G. Sal, 1993, The Journal of biological chemistry.

cDNA cloning of the neutrophil bactericidal peptide indolicidin.

G. Del Sal, C. Schneider, P. Storici, 1992, Biochemical and biophysical research communications.

Molecular architecture of the glycogen- committed PP1/PTG holoenzyme

P. Storici, N. Demitri, A. Cassetta, 2022, Nature Communications.

A covalent PIN1 inhibitor selectively targets cancer cells by a dual mechanism of action

A. Rosato, P. Carloni, E. Baloglu, 2017, Nature Communications.

Easy access to α-ketoamides as SARS-CoV-2 and MERS Mpro inhibitors via the PADAM oxidation route

M. Brindisi, V. Summa, P. Storici, 2022, European Journal of Medicinal Chemistry.

Fourier transform infrared microspectroscopy reveals biochemical changes associated with glioma stem cell differentiation.

P. Storici, L. Vaccari, A. Vindigni, 2015, Biophysical chemistry.

Structures of GABA Aminotransferase, a Pyridoxal 5'-Phosphate and [2Fe-2S] Cluster Containing Enzyme, Complexed with g -EthynylGABA and with the Antiepilepsy Drug Vigabatrin

A. Mozzarelli, F. Bossa, S. Bruno, 2003 .

An approach combining rapid cDNA amplification and chemical synthesis for the identification of novel, cathelicidin-derived, antimicrobial peptides.

P. Storici, R. Gennaro, A. Tossi, 1997, Methods in molecular biology.

Structures of γ-Aminobutyric Acid (GABA) Aminotransferase, a Pyridoxal 5′-Phosphate, and [2Fe-2S] Cluster-containing Enzyme, Complexed with γ-Ethynyl-GABA and with the Antiepilepsy Drug Vigabatrin*

Paola Storici, Francesco Bossa, Andrea Mozzarelli, 2003, Journal of Biological Chemistry.

Identification of 4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline derivatives as a new class of orally and selective Polo-like kinase 1 inhibitors.

D. Ballinari, V. Croci, D. Volpi, 2010, Journal of medicinal chemistry.

1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles: identification of a potent Aurora kinase inhibitor with a favorable antitumor kinase inhibition profile.

Paola Storici, Maurizio Rocchetti, Enrico Pesenti, 2006, Journal of medicinal chemistry.

Potent and selective Aurora inhibitors identified by the expansion of a novel scaffold for protein kinase inhibition.

A. Vulpetti, F. Roletto, P. Cappella, 2005, Journal of medicinal chemistry.

Thieno[3,2-c]pyrazoles: a novel class of Aurora inhibitors with favorable antitumor activity.

V. Croci, D. Volpi, F. Roletto, 2010, Bioorganic & medicinal chemistry.

A Triazolotriazine‐Based Dual GSK‐3β/CK‐1δ Ligand as a Potential Neuroprotective Agent Presenting Two Different Mechanisms of Enzymatic Inhibition

A. Cavalli, Maicol Bissaro, S. Moro, 2019, ChemMedChem.

Structure of 1-aminocyclopropane-1-carboxylate synthase, a key enzyme in the biosynthesis of the plant hormone ethylene.

G Capitani, J. Kirsch, G. Capitani, 1999, Journal of molecular biology.

Emerging SARS-CoV-2 mutation hot spots include a novel RNA-dependent-RNA polymerase variant

M. Ciccozzi, R. Gallo, P. Storici, 2020, Journal of Translational Medicine.

Engineering methionine γ-lyase from Citrobacter freundii for anticancer activity.

A. Mozzarelli, L. Pollegioni, E. Gabellieri, 2018, Biochimica et biophysica acta. Proteins and proteomics.

Crystal structure of osmoporin OmpC from E. coli at 2.0 A.

Paola Storici, Arnaud Baslé, G. Rummel, 2006, Journal of molecular biology.

Design of a conformationally restricted analogue of the antiepilepsy drug Vigabatrin that directs its mechanism of inactivation of gamma-aminobutyric acid aminotransferase.

Sun Choi, P. Storici, R. Silverman, 2002, Journal of the American Chemical Society.

Purification and structural characterization of bovine cathelicidins, precursors of antimicrobial peptides.

B. Lenarčič, P. Storici, A. Tossi, 1996, European journal of biochemistry.

PMAP-37, a novel antibacterial peptide from pig myeloid cells. cDNA cloning, chemical synthesis and activity.

P. Storici, R. Gennaro, A. Tossi, 1995, European journal of biochemistry.

Chemical synthesis and biological activity of a novel antibacterial peptide deduced from a pig myeloid cDNA

P. Storici, R. Gennaro, A. Tossi, 1994, FEBS letters.

cDNA sequence analysis of an antibiotic dodecapeptide from neutrophils

G. Del Sal, C. Schneider, P. Storici, 1992, FEBS letters.

Structural and Biochemical Analysis of the Dual Inhibition of MG-132 against SARS-CoV-2 Main Protease (Mpro/3CLpro) and Human Cathepsin-L

G. Rossetti, P. Storici, N. Demitri, 2021, International journal of molecular sciences.

Structural basis of the specificity of USP18 toward ISG15

K. Knobeloch, H. Ovaa, P. Storici, 2017, Nature Structural &Molecular Biology.

Identification of Novel GSK-3β Hits Using Competitive Biophysical Assays

A. Cavalli, T. Bandiera, M. Veronesi, 2022, International journal of molecular sciences.

A consensus protocol for the in silico optimisation of antibody fragments.

Alessandro Laio, Paola Storici, Miguel A. Soler, 2019, Chemical communications.

Topoisomerase IIβ mediates the resistance of glioblastoma stem cells to replication stress-inducing drugs

M. Skrap, T. Ius, P. Storici, 2016, Cancer Cell International.

Crystallization and preliminary crystallographic investigations of rhodanese from Azotobacter vinelandii.

M. Bolognesi, P. Storici, D. Bordo, 1999, Acta crystallographica. Section D, Biological crystallography.

Community-wide experimental evaluation of the PROSS stability-design method.

Y. Peleg, O. Dym, S. Albeck, 2021, Journal of molecular biology.

Investigating Drug-Target Residence Time in Kinases through Enhanced Sampling Simulations.

A. Cavalli, R. D. Di Martino, P. Storici, 2019, Journal of chemical theory and computation.

L‐serine biosynthesis in the human central nervous system: Structure and function of phosphoserine aminotransferase

A. Mozzarelli, G. Murtas, L. Pollegioni, 2023, Protein science : a publication of the Protein Society.

Identification of Inhibitors of SARS-CoV-2 3CL-Pro Enzymatic Activity Using a Small Molecule in Vitro Repurposing Screen

F. Musiani, Daniela Iaconis, V. Summa, 2021, ACS pharmacology & translational science.

Design, synthesis, biological evaluation and structural characterization of novel GEBR library PDE4D inhibitors.

C. Brullo, Tommaso Prosdocimi, E. Parisini, 2021, European journal of medicinal chemistry.

Insight into GEBR-32a: Chiral Resolution, Absolute Configuration and Enantiopreference in PDE4D Inhibition

C. Brullo, F. Vasile, E. Parisini, 2020, Molecules.

Further insights into the assessment of cell cycle phases by FTIR microspectroscopy

P. Storici, L. Vaccari, S. Kenig, 2014 .

Binding of tyrosine kinase inhibitor to epidermal growth factor receptor: surface-enhanced infrared absorption microscopy reveals subtle protein secondary structure variations.

A. Hubarevich, P. Storici, L. Vaccari, 2021, Nanoscale.

An anti-HER2 nanobody binds to its antigen HER2 via two independent paratopes.

C. Iacobucci, A. Sinz, R. Grandori, 2021, International journal of biological macromolecules.

Soft X-Ray Microscopy Radiation Damage On Fixed Cells Investigated With Synchrotron Radiation FTIR Microscopy

M. Kiskinova, G. Kourousias, A. Gianoncelli, 2015, Scientific Reports.

Broad-spectrum coronavirus 3C-like protease peptidomimetic inhibitors effectively block SARS-CoV-2 replication in cells: Design, synthesis, biological evaluation, and X-ray structure determination

M. Brindisi, V. Summa, P. Storici, 2023, European Journal of Medicinal Chemistry.

Known Drugs Identified by Structure-Based Virtual Screening Are Able to Bind Sigma-1 Receptor and Increase Growth of Huntington Disease Patient-Derived Cells

A. Vescovi, A. Ilari, A. Fiorillo, 2021, International Journal of Molecular Sciences.

Topoisomerase IIβ mediates the resistance of glioblastoma stem cells to replication stress-inducing drugs

M. Skrap, T. Ius, P. Storici, 2016, Cancer Cell International.

Synthesis, characterization, and optimization for in vivo delivery of a nonselective isopeptidase inhibitor as new antineoplastic agent.

C. Brancolini, P. Storici, F. Berti, 2015, Journal of medicinal chemistry.

ARN25068, a versatile starting point towards triple GSK-3β/FYN/DYRK1A inhibitors to tackle tau-related neurological disorders.

R. Abagyan, A. Cavalli, R. D. Di Martino, 2021, European journal of medicinal chemistry.

Identification of inhibitors of SARS-CoV-2 3CL-Pro enzymatic activity using a small molecule in-vitro repurposing screen

F. Musiani, Daniela Iaconis, J. Neyts, 2020 .

Identification of Inhibitors of SARS-CoV-2 3CL-Pro Enzymatic Activity Using a Small Molecule in Vitro Repurposing Screen

F. Musiani, Daniela Iaconis, J. Neyts, 2021, ACS Pharmacology & Translational Science.

A. Mozzarelli, F. Bossa, S. Bruno, 2003, Journal of Biological Chemistry.