Nicholas H Williams

发表

Photocatalytic Nanolithography of Self-Assembled Monolayers and Proteins

Nicholas D. Spencer, Esther Amstad, Graham J. Leggett, 2013, ACS nano.

Atomic details of near-transition state conformers for enzyme phosphoryl transfer revealed by MgF 3 - rather than by phosphoranes

N. J. Baxter, A. Hounslow, J. Waltho, 2010, Proceedings of the National Academy of Sciences.

15 Bioinspired organic chemistry

Nicholas H Williams, 2004 .

Models for biological phosphoryl transfer.

Nicholas H Williams, 2004, Biochimica et biophysica acta.

Highly selective colorimetric sensing pyrophosphate in water by a NBD-phenoxo-bridged dinuclear Zn(II) complex.

Nicholas H Williams, Shengjun Yang, Guoqiang Feng, 2012, Organic & biomolecular chemistry.

Modeling the Alkaline Hydrolysis of Diaryl Sulfate Diesters: A Mechanistic Study

Shina Caroline Lynn Kamerlin, A. Hengge, Nicholas H Williams, 2020, The Journal of organic chemistry.

Metal-ion catalysed phosphate diester transesterification: quantifying double Lewis-acid activation

Nicholas H Williams, J. Chin, 1996 .

Enhancing Phosphate Diester Cleavage by a Zinc Complex through Controlling Nucleophile Coordination.

Nicholas H Williams, Emmanuel Y Tirel, 2015, Chemistry.

Phosphate diester hydrolysis within a highly reactive dinuclear cobalt(III) complex. Ligand effect on reactivity, transition state and dissociation

P. Wyman, Nicholas H Williams, 2001 .

The rate of hydrolysis of phosphomonoester dianions and the exceptional catalytic proficiencies of protein and inositol phosphatases

R. Wolfenden, Nicholas H Williams, Chetan Lad, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Intramolecular general base catalysis in the hydrolysis of a phosphate diester. Calculational guidance to a choice of mechanism.

Nicholas H Williams, F. Nome, J. R. Mora, 2013, The Journal of organic chemistry.

Phosphylated tyrosine in albumin as a biomarker of exposure to organophosphorus nerve agents

Nicholas H Williams, R. Read, R. Black, 2007, Archives of Toxicology.

The Alkaline Hydrolysis of Sulfonate Esters: Challenges in Interpreting Experimental and Theoretical Data

Shina Caroline Lynn Kamerlin, Nicholas H Williams, F. Duarte, 2013, The Journal of organic chemistry.

Binding of Hydrophobic Guests in a Coordination Cage Cavity is Driven by Liberation of “High‐Energy” Water

M. Ward, Nicholas H Williams, W. Cullen, 2017, Chemistry.

Coordination‐Cage‐Catalysed Hydrolysis of Organophosphates: Cavity‐ or Surface‐Based?

M. Ward, Fatma M. Ashour, Nicholas H Williams, 2019, Chemistry.

Modeling the Alkaline Hydrolysis of Diaryl Sulfate Diesters: A Mechanistic Study

Shina Caroline Lynn Kamerlin, A. Hengge, Nicholas H Williams, 2020, The Journal of organic chemistry.

Controlled membrane translocation provides a mechanism for signal transduction and amplification.

C. Hunter, Nicholas H Williams, Matthew J. Langton, 2017, Nature chemistry.

Adhesion between oppositely charged polyelectrolytes in salt solution

Nicholas H Williams, M. Geoghegan, L. Alfhaid, 2020, Journal of Applied Polymer Science.

Synthesis and anticholinesterase activity of some new fluorogenic analogues of organophosphorus nerve agents

Gareth R. Williams, Nicholas H Williams, C. Timperley, 2006 .

A Synthetic Vesicle-to-Vesicle Communication System.

C. Hunter, Nicholas H Williams, Yudi Ding, 2019, Journal of the American Chemical Society.

Three Metal Ions Participate in the Reaction Catalyzed by T5 Flap Endonuclease*

J. Tainer, J. Grasby, Nicholas H Williams, 2008, Journal of Biological Chemistry.

Adhesion of Grafted-to Polyelectrolyte Brushes Functionalized with Calix[4]resorcinarene and Deposited as a Monolayer.

Nicholas H Williams, A. Dunbar, M. Geoghegan, 2020, Langmuir : the ACS journal of surfaces and colloids.

Cleavage and isomerization of UpU promoted by dinuclear metal ion complexes.

Nicholas H Williams, S. Mikkola, Guoqiang Feng, 2008, Journal of the American Chemical Society.

A highly reactive mononuclear Zn(II) complex for phosphodiester cleavage.

Nicholas H Williams, Guoqiang Feng, R. Torres Martín de Rosales, 2005, Journal of the American Chemical Society.

Guest Binding and Catalysis in the Cavity of a Cubic Coordination Cage

C. Hunter, M. Ward, Nicholas H Williams, 2017 .

Structure and Nuclease Activity of Simple Dinuclear Metal Complexes: Quantitative Dissection of the Role of Metal Ions

Nicholas H Williams, J. Chin, M. Wall, 1999 .

Reactivity of Phosphate Diesters Doubly Coordinated to a Dinuclear Cobalt(III) Complex: Dependence of the Reactivity on the Basicity of the Leaving Group

Nicholas H Williams, J. Chin, William K. Cheung, 1998 .

The time required for water attack at the phosphorus atom of simple phosphodiesters and of DNA.

R. Wolfenden, P. Wyman, Nicholas H Williams, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Efficient phosphodiester binding and cleavage by a ZnII complex combining hydrogen-bonding interactions and double Lewis acid activation.

Nicholas H Williams, R. Prabaharan, D. Natale, 2006, Angewandte Chemie.

Comparing a mononuclear Zn(II) complex with hydrogen bond donors with a dinuclear Zn(II) complex for catalysing phosphate ester cleavage.

Nicholas H Williams, Guoqiang Feng, J. Mareque‐Rivas, 2006, Chemical communications.

Altered mechanisms of reactions of phosphate esters bridging a dinuclear metal center.

A. Hengge, Nicholas H Williams, M. Forconi, 2004, Journal of the American Chemical Society.

An altered mechanism of hydrolysis for a metal-complexed phosphate diester.

A. Hengge, Nicholas H Williams, M. Forconi, 2002, Journal of the American Chemical Society.

A Structural and Functional Model of Dinuclear Metallophosphatases

Nicholas H Williams, J. Chin, ‡. A. A. Lebuis, 1999 .

Dinuclear Zn(II) complex promotes cleavage and isomerization of 2-hydroxypropyl alkyl phosphates by a common cyclic phosphate intermediate.

D. Edwards, Nicholas H Williams, R. S. Brown, 2009, Journal of the American Chemical Society.

βLG values in mechanistic studies on the transesterification of RNA models and their application in a metal ion complex promoted transesterification

Heidi J. Korhonen, Nicholas H Williams, S. Mikkola, 2013 .

The mechanism of cleavage and isomerisation of RNA promoted by an efficient dinuclear Zn2+ complex.

Heidi J. Korhonen, Nicholas H Williams, S. Mikkola, 2012, Chemistry.

Mononuclear Co(III)-complex promoted phosphate diester hydrolysis: dependence of reactivity on the leaving group†

P. Wyman, Nicholas H Williams, M. Padovani, 2004 .

Phosphate ester analogues as probes for understanding enzyme catalysed phosphoryl transfer

A. Warshel, Nicholas H Williams, S. C. Kamerlin, 2010 .

Identification of iso- and n-propylphosphonates using liquid chromatography-tandem mass spectrometry and gas chromatography-Fourier transform infrared spectroscopy.

D. B. Cooper, Nicholas H Williams, C. Timperley, 2004, Journal of chromatography. A.

A novel solid support for synthesis of 2′,3′-cyclic phosphate terminated oligonucleotides

J. Grasby, Nicholas H Williams, J. S. Vyle, 1998 .

13 Bioinspired organic chemistry

Nicholas H Williams, 2003 .

Highly efficient catalysis of the Kemp elimination in the cavity of a cubic coordination cage.

C. Hunter, M. Ward, Nicholas H Williams, 2016, Nature chemistry.

Trimorphism in solid resorcinarenes.

Nicholas H Williams, C. Stirling, L. J. Fundin, 2007, Chemical communications.

Triggered Release from Lipid Bilayer Vesicles by an Artificial Transmembrane Signal Transduction System.

C. Hunter, Nicholas H Williams, Matthew J. Langton, 2017, Journal of the American Chemical Society.

Recognition-Controlled Membrane Translocation for Signal Transduction across Lipid Bilayers.

C. Hunter, Nicholas H Williams, Matthew J. Langton, 2017, Journal of the American Chemical Society.

14 Bioinspired organic chemistry

Nicholas H Williams, 2005 .

Catalysis in a Cationic Coordination Cage Using a Cavity-Bound Guest and Surface-Bound Anions: Inhibition, Activation, and Autocatalysis.

M. Ward, Nicholas H Williams, A. Wragg, 2018, Journal of the American Chemical Society.

Coordination Cages Based on Bis(pyrazolylpyridine) Ligands: Structures, Dynamic Behavior, Guest Binding, and Catalysis.

C. Hunter, M. Ward, Nicholas H Williams, 2018, Accounts of chemical research.

Transmission of binding information across lipid bilayers.

C. Hunter, H. Dijkstra, Nicholas H Williams, 2007, Chemistry.

Mechanism and transition state structure of aryl methylphosphonate esters doubly coordinated to a dinuclear cobalt(III) center.

H. Adams, A. Hengge, Nicholas H Williams, 2009, Journal of the American Chemical Society.

Catalytic Zinc Complexes for Phosphate Diester Hydrolysis

H. Adams, Nicholas H Williams, F. Duarte, 2014, Angewandte Chemie.

Cooperative binding at lipid bilayer membrane surfaces.

C. Hunter, Emma L. Doyle, Nicholas H Williams, 2003, Journal of the American Chemical Society.

Evaluation of anti-inflammatory calixarene-peptides for biomaterial modification

J. Haycock, Nicholas H Williams, K. Fairfull‐Smith, 2006 .

Comment on "The Pentacovalent Phosphorus Intermediate of a Phosphoryl Transfer Reaction"

S. Smerdon, S. Gamblin, Nicholas H Williams, 2003, Science.

Fibre optic absorbance meter with low limit of detection for waterborne cations

M. Grell, Nicholas H Williams, Kirwa Abraham Tuwei, 2016 .

Analogues with fluorescent leaving groups for screening and selection of enzymes that efficiently hydrolyze organophosphorus nerve agents.

Gareth R. Williams, A. Fersht, A. Griffiths, 2006, Journal of medicinal chemistry.

Generation of Bioactive Materials with Rapid Self‐Assembling Resorcinarene‐Peptides

J. Haycock, Nicholas H Williams, K. Fairfull‐Smith, 2009 .

Amino-functionalized DNA: the properties of C5-amino-alkyl substituted 2′-deoxyuridines and their application in DNA triplex formation

B. F. Taylor, Nicholas H Williams, David M Williams, 2005, Nucleic acids research.

Oligonucleotide based artificial nuclease (OBAN) systems. Bulge size dependence and positioning of catalytic group in cleavage of RNA-bulges.

R. Strömberg, Nicholas H Williams, Hans Åström, 2003, Organic & biomolecular chemistry.

Transmembrane signal transduction by cofactor transport

I. Kocsis, Nicholas H Williams, Yudi Ding, 2021, Chemical science.

The effect of magnesium ions on triphosphate hydrolysis

Nicholas H Williams, S. C. Kamerlin, Alexandre Barrozo, 2017 .

The solvolysis mechanism of simple secondary tosylates in 50% aqueous TFE†

Nicholas H Williams, Dian Li, 2016 .

DNA Hydrolysis: Mechanism and Reactivity

Nicholas H Williams, 2004 .

Fabrication of molecular nanopatterns at aluminium oxide surfaces by nanoshaving of self-assembled monolayers of alkylphosphonates.

G. Leggett, Nicholas H Williams, I. Barlow, 2013, Nanoscale.

Resolving Apparent Conflicts between Theoretical and Experimental Models of Phosphate Monoester Hydrolysis

Shina Caroline Lynn Kamerlin, Nicholas H Williams, F. Duarte, 2014, Journal of the American Chemical Society.

The Competing Mechanisms of Phosphate Monoester Dianion Hydrolysis

Shina Caroline Lynn Kamerlin, Nicholas H Williams, F. Duarte, 2016, Journal of the American Chemical Society.

Simulating the reactions of substituted pyridinio-N-phosphonates with pyridine as a model for biological phosphoryl transfer.

Nicholas H Williams, A. Pabis, S. C. Kamerlin, 2017, Organic & biomolecular chemistry.

Neutralizing Mutations of Carboxylates That Bind Metal 2 in T5 Flap Endonuclease Result in an Enzyme That Still Requires Two Metal Ions*

J. Tainer, J. Grasby, Nicholas H Williams, 2011, The Journal of Biological Chemistry.

Activating water: important effects of non-leaving groups on the hydrolysis of phosphate triesters.

Nicholas H Williams, F. Nome, Elisa S. Orth, 2011, Chemistry.

Kinetic analysis of beta-phosphoglucomutase and its inhibition by magnesium fluoride.

F. Hollfelder, N. J. Baxter, J. Waltho, 2009, Journal of the American Chemical Society.

A Trojan horse transition state analogue generated by MgF3− formation in an enzyme active site

F. Hollfelder, N. J. Baxter, A. Hounslow, 2006, Proceedings of the National Academy of Sciences.

'Rough guide' evanescent wave optrode for colorimetric metalloporphyrine sensors.

M. Grell, R. Paolesse, C. Di Natale, 2017, Talanta.

Amphiphilic spin probes based on disulfide-bridged bisnitroxides

Nicholas H Williams, V. Chechik, V. Khlestkin, 2008 .

Generic methods for micrometer- and nanometer-scale surface derivatization based on photochemical coupling of primary amines to monolayers of aryl azides on gold and aluminum oxide surfaces.

E. ul-Haq, G. Leggett, Nicholas H Williams, 2013, Langmuir : the ACS journal of surfaces and colloids.

Transition States and Control of Substrate Preference in the Promiscuous Phosphatase PP1.

A. Hengge, Nicholas H Williams, Y. Chu, 2017, Biochemistry.

Mechanistic study of protein phosphatase-1 (PP1), a catalytically promiscuous enzyme.

A. Hengge, Nicholas H Williams, Q. I. Sheikh, 2008, Journal of the American Chemical Society.

Anionic charge is prioritized over geometry in aluminum and magnesium fluoride transition state analogs of phosphoryl transfer enzymes.

F. Hollfelder, D. Wemmer, N. J. Baxter, 2008, Journal of the American Chemical Society.

Evaluation of Anti-Inflammatory and Antimicrobial Resorcinarene-Peptides for Biomaterial Modification

J. Haycock, Nicholas H Williams, C. Douglas, 2007 .

Double-network hydrogels improve pH-switchable adhesion.

Nicholas H Williams, M. Geoghegan, L. Alfhaid, 2016, Soft matter.

How to name atoms in phosphates, polyphosphates, their derivatives and mimics, and transition state analogues for enzyme-catalysed phosphoryl transfer reactions (IUPAC Recommendations 2016)

G. P. Moss, J. Cherfils, A. Wittinghofer, 2017 .

Brønsted analysis and rate-limiting steps for the T5 flap endonuclease catalyzed hydrolysis of exonucleolytic substrates.

J. Grasby, Nicholas H Williams, J. Sayers, 2010, Biochemistry.

Cleavage and isomerization of UpU promoted by dinuclear metal ion complexes.

Nicholas H Williams, S. Mikkola, Guoqiang Feng, 2008, Journal of the American Chemical Society.

MgF(3)(-) and alpha-galactose 1-phosphate in the active site of beta-phosphoglucomutase form a transition state analogue of phosphoryl transfer.

N. J. Baxter, A. Hounslow, J. Waltho, 2009, Journal of the American Chemical Society.