V. Rao

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Portal-Large Terminase Interactions of the Bacteriophage T4 DNA Packaging Machine Implicate a Molecular Lever Mechanism for Coupling ATPase to DNA Translocation

Venigalla B Rao, Shylaja Hegde, Dr Victor Padilla-Sanchez, PhD, 2012, Journal of Virology.

A prokaryotic-eukaryotic hybrid viral vector for delivery of large cargos of genes and proteins into human cells

J. Sha, A. Chopra, V. Rao, 2019, Science Advances.

A phage T4 in vitro packaging system for cloning long DNA molecules.

L. Black, V. Rao, V. Thaker, 1992, Gene.

Molecular architecture of bacteriophage T4 capsid: vertex structure and bimodal binding of the stabilizing accessory protein, Soc.

B L Trus, A C Steven, B. Trus, 2000, Virology.

Structure, assembly, and DNA packaging of the bacteriophage T4 head.

L. Black, V. Rao, 2012, Advances in virus research.

Bacteriophage T4 nanoparticles for vaccine delivery against infectious diseases.

V. Rao, Jingen Zhu, Pan Tao, 2019, Advanced drug delivery reviews.

A virus DNA gate: Zipping and unzipping the packed viral genome

V. Rao, 2009, Proceedings of the National Academy of Sciences.

Molecular architecture of the prolate head of bacteriophage T4.

Michael G Rossmann, Venigalla B Rao, M. Rossmann, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Specificity of Interactions among the DNA-packaging Machine Components of T4-related Bacteriophages*

V. Rao, Song Gao, 2010, The Journal of Biological Chemistry.

Analysis of capsid portal protein and terminase functional domains: interaction sites required for DNA packaging in bacteriophage T4.

L. Black, V. Rao, H. Lin, 1999, Journal of molecular biology.

The DNA translocating ATPase of bacteriophage T4 packaging motor.

V. Rao, Kiran Kondabagil, Zhihong Zhang, 2006, Journal of molecular biology.

Assembly of Human Immunodeficiency Virus (HIV) Antigens on Bacteriophage T4: a Novel In Vitro Approach To Construct Multicomponent HIV Vaccines

D. Birx, C. Alving, V. Rao, 2006, Journal of Virology.

A Bacteriophage T4 Nanoparticle-Based Dual Vaccine against Anthrax and Plague

J. Sha, A. Chopra, M. Moayeri, 2018, mBio.

Highly Effective Soluble and Bacteriophage T4 Nanoparticle Plague Vaccines Against Yersinia pestis.

V. Rao, Pan Tao, Marthandan Mahalingam, 2016, Methods in molecular biology.

Mutated and Bacteriophage T4 Nanoparticle Arrayed F1-V Immunogens from Yersinia pestis as Next Generation Plague Vaccines

J. Sha, A. Chopra, V. Rao, 2013, PLoS pathogens.

Preparation of a Bacteriophage T4-based Prokaryotic-eukaryotic Hybrid Viral Vector for Delivery of Large Cargos of Genes and Proteins into Human Cells.

V. Rao, Jingen Zhu, Pan Tao, 2020, Bio-protocol.

HIV-1 variable loop 2 and its importance in HIV-1 infection and vaccine development.

N. Michael, C. Alving, V. Rao, 2013, Current HIV research.

CRISPR Engineering of Bacteriophage T4 to Design Vaccines Against SARS-CoV-2 and Emerging Pathogens.

V. Rao, Jingen Zhu, Himanshu Batra, 2021, Methods in molecular biology.

Selection and immune recognition of HIV-1 MPER mimotopes.

V. Polonis, N. Steers, V. Rao, 2020, Virology.

Liposomes containing glucosyl ceramide specifically bind T4 bacteriophage: a self-assembling nanocarrier formulation

C. Alving, V. Rao, M. Rao, 2011, Journal of liposome research.

A universal bacteriophage T4 nanoparticle platform to design multiplex SARS-CoV-2 vaccine candidates by CRISPR engineering

J. Sha, A. Chopra, V. Rao, 2021, bioRxiv.

A universal bacteriophage T4 nanoparticle platform to design multiplex SARS-CoV-2 vaccine candidates by CRISPR engineering

J. Sha, A. Chopra, V. Rao, 2021, Science advances.

A Bacteriophage-Based, Highly Efficacious, Needle- and Adjuvant-Free, Mucosal COVID-19 Vaccine

J. Sha, A. Chopra, V. Rao, 2022, bioRxiv.

Engineered Bacteriophage T4 Nanoparticle as a Potential Targeted Activator of HIV-1 Latency in CD4+ Human T-cells

V. Rao, F. Maldarelli, Jingen Zhu, 2021, bioRxiv.

Sequence analysis of bacteriophage T4 DNA packaging/terminase genes 16 and 17 reveals a common ATPase center in the large subunit of viral terminases.

V. Rao, M. Mitchell, S. Imai, 2002, Nucleic acids research.

Anthrax LFn-PA Hybrid Antigens: Biochemistry, Immunogenicity, and Protection Against Lethal Ames Spore Challenge in Rabbits.

J. Peterson, L. Sower, S. Leppla, 2009, The Open Vaccine Journal.

Cryo-electron microscopy study of bacteriophage T4 displaying anthrax toxin proteins.

M. Rossmann, V. Bowman, A. Fokine, 2007, Virology.

Genetic Engineering of Bacteriophages Against Infectious Diseases

V. Rao, Pan Tao, Himanshu Batra, 2019, Front. Microbiol..

Highly effective generic adjuvant systems for orphan or poverty-related vaccines.

Qin Li, G. Matyas, C. Alving, 2011, Vaccine.

The complex roles of genomic DNA modifications of bacteriophage T4 in resistance to nuclease-based defense systems of E. coli

V. Rao, Pan Tao, P. Qian, 2022, bioRxiv.

Defining the bacteriophage T4 DNA packaging machine: evidence for a C-terminal DNA cleavage domain in the large terminase/packaging protein gp17.

V. Rao, F. Rentas, 2003, Journal of molecular biology.

A viral genome packaging ring-ATPase is a flexibly coordinated pentamer

T. Ha, Y. Chemla, V. Rao, 2021, Nature Communications.

Single-molecule packaging initiation in real time by a viral DNA packaging machine from bacteriophage T4

K. Dahmen, T. Ha, T. Earnest, 2014, Proceedings of the National Academy of Sciences.

Bacteriophage Vaccines

V. Rao, Pan Tao, 2021, Encyclopedia of Virology.

Regulation by interdomain communication of a headful packaging nuclease from bacteriophage T4

Bonnie Draper, V. Rao, T. I. Alam, 2010, Nucleic acids research.

Membrane-associated assembly of a phage T4 DNA entrance vertex structure studied with expression vectors.

G. Michaud, L. Black, V. Rao, 1989, Journal of molecular biology.

A phage-encoded nucleoid associated protein compacts both host and phage DNA and derepresses H-NS silencing.

E. Dimitriadis, D. Hinton, V. Rao, 2021, Nucleic acids research.

DNA packaging of bacteriophage T4 proheads in vitro. Evidence that prohead expansion is not coupled to DNA packaging.

L. Black, V. Rao, 1985, Journal of molecular biology.

Bacteriophage T4 as a nanovehicle for delivery of genes and therapeutics into human cells.

V. Rao, Jingen Zhu, 2022, Current opinion in virology.

THE CATHOLIC UNIVERSITY OF AMERICA

J. J. Greene, V. Rao, P. Tuma, 2011 .

A Promiscuous DNA Packaging Machine from Bacteriophage T4

T. Ha, Y. Chemla, V. Rao, 2011, PLoS biology.

Evidence that a phage T4 DNA packaging enzyme is a processed form of the major capsid gene product

L. Black, V. Rao, 1985, Cell.

Structure and assembly of bacteriophage T4 head

Venigalla B Rao, L. Black, V. Rao, 2010, Virology Journal.

The bacteriophage DNA packaging motor.

M. Feiss, V. Rao, 2008, Annual review of genetics.

A discontinuous headful packaging model for packaging less than headful length DNA molecules by bacteriophage T4.

V. Rao, G. Leffers, 1996, Journal of molecular biology.

Function of a viral genome packaging motor from bacteriophage T4 is insensitive to DNA sequence

S. Harvey, Douglas E. Smith, V. Rao, 2020, Nucleic acids research.

Bacteriophage T4 Vaccine Platform for Next-Generation Influenza Vaccine Development

V. Rao, Wanpo Zhang, Pan Tao, 2021, bioRxiv.

Assembly of the small outer capsid protein, Soc, on bacteriophage T4: a novel system for high density display of multiple large anthrax toxins and foreign proteins on phage capsid.

V. Rao, Qin Li, S. B. Shivachandra, 2007, Journal of molecular biology.

Bacteriophage T4 Escapes CRISPR Attack by Minihomology Recombination and Repair

V. Rao, Jingen Zhu, Pan Tao, 2021, mBio.

Covalent Modifications of the Bacteriophage Genome Confer a Degree of Resistance to Bacterial CRISPR Systems

V. Rao, Jingen Zhu, Pan Tao, 2020, Journal of Virology.

Strategies for direct sequencing of PCR-amplified DNA.

V. Rao, V B Rao, 1994, PCR methods and applications.

Mechanisms of DNA Packaging by Large Double-Stranded DNA Viruses.

M. Feiss, V. Rao, 2015, Annual review of virology.

Adenine recognition is a key checkpoint in the energy release mechanism of phage T4 DNA packaging motor.

Bonnie Draper, V. Rao, Kiran Kondabagil, 2012, Journal of molecular biology.

Single phage T4 DNA packaging motors exhibit large force generation, high velocity, and dynamic variability

Derek N. Fuller, Dorian M. Raymer, Venigalla B Rao, 2007, Proceedings of the National Academy of Sciences.

An ATP hydrolysis sensor in the DNA packaging motor from bacteriophage T4 suggests an inchworm-type translocation mechanism.

Bonnie Draper, V. Rao, 2007, Journal of molecular biology.

The structure of the ATPase that powers DNA packaging into bacteriophage T4 procapsids.

Michael G Rossmann, Venigalla B Rao, Kiran Kondabagil, 2007, Molecular cell.

Molecular anatomy of the receptor binding module of a bacteriophage long tail fiber

M. Rossmann, A. Fokine, V. Rao, 2019, PLoS pathogens.

Structure of the Three N-Terminal Immunoglobulin Domains of the Highly Immunogenic Outer Capsid Protein from a T4-Like Bacteriophage

M. Rossmann, V. Bowman, A. Fokine, 2011, Journal of Virology.

Dynamic Shifts in the HIV Proviral Landscape During Long Term Combination Antiretroviral Therapy: Implications for Persistence and Control of HIV Infections

S. Hughes, E. Boritz, J. Coffin, 2020, Viruses.

The Small Terminase, gp16, of Bacteriophage T4 Is a Regulator of the DNA Packaging Motor*

V. Rao, Kiran Kondabagil, N. Kelly, 2009, The Journal of Biological Chemistry.

The Structure of the Phage T4 DNA Packaging Motor Suggests a Mechanism Dependent on Electrostatic Forces

Michael G. Rossmann, Valorie D. Bowman, Venigalla B. Rao, 2008, Cell.

Structure and function of the small terminase component of the DNA packaging machine in T4-like bacteriophages

M. Rossmann, Y. Xiang, V. Rao, 2011, Proceedings of the National Academy of Sciences.

Engineering of Bacteriophage T4 Genome Using CRISPR-Cas9.

V. Rao, Jingen Zhu, Pan Tao, 2017, ACS synthetic biology.

A novel terminase activity associated with the DNA packaging protein gp17 of bacteriophage T4.

V. Rao, S. Bhattacharyya, S. Bhattacharyya, 1993, Virology.

The bacteriophage DNA packaging machine.

M. Feiss, V. Rao, 2012, Advances in experimental medicine and biology.

Genome packaging in viruses.

M. Rossmann, V. Rao, Siyang Sun, 2010, Current opinion in structural biology.

A Bivalent Anthrax–Plague Vaccine That Can Protect against Two Tier-1 Bioterror Pathogens, Bacillus anthracis and Yersinia pestis

A. Chopra, M. Moayeri, V. Rao, 2017, Front. Immunol..

Bacteriophage T4 Head: Structure, Assembly, and Genome Packaging

A. Fokine, V. Rao, Q. Fang, 2023, Viruses.

Exclusion of small terminase mediated DNA threading models for genome packaging in bacteriophage T4

V. Rao, Song Gao, Liang Zhang, 2016, Nucleic acids research.

Cryo-EM structure of the bacteriophage T4 portal protein assembly at near-atomic resolution

Sriram Subramaniam, Michael G. Rossmann, Venigalla B. Rao, 2015, Nature Communications.

The headful packaging nuclease of bacteriophage T4

M. Rossmann, Bonnie Draper, V. Rao, 2008, Molecular microbiology.

Biochemical Characterization of an ATPase Activity Associated with the Large Packaging Subunit gp17 from Bacteriophage T4*

V. Rao, G. Leffers, 2000, The Journal of Biological Chemistry.

Cloning, overexpression and purification of the terminase proteins gp16 and gp17 of bacteriophage T4. Construction of a defined in-vitro DNA packaging system using purified terminase proteins.

L. Black, V. Rao, 1988, Journal of molecular biology.

Effect of cytokines on Siglec-1 and HIV-1 entry in monocyte–derived macrophages: the importance of HIV-1 envelope V1V2 region

Jerome H. Kim, N. Michael, C. Alving, 2015, Journal of leukocyte biology.

A sequestered fusion peptide in the structure of an HIV-1 transmitted founder envelope trimer

M. Rossmann, M. Robb, Zhenguo Chen, 2019, Nature Communications.

A sequestered fusion peptide in the structure of an HIV-1 transmitted founder envelope trimer

M. Rossmann, M. Robb, Zhenguo Chen, 2019, Nature Communications.

Structural morphing in a symmetry-mismatched viral vertex

M. Rossmann, A. Fokine, V. Rao, 2020, Nature Communications.

Cryo-EM structure of the bacteriophage T4 isometric head at 3.3-Å resolution and its relevance to the assembly of icosahedral viruses

M. Rossmann, D. Hanein, Zhenguo Chen, 2017, Proceedings of the National Academy of Sciences.

In vitro and in vivo delivery of genes and proteins using the bacteriophage T4 DNA packaging machine

A. Chopra, V. Rao, Pan Tao, 2013, Proceedings of the National Academy of Sciences.

Fc receptor engagement of HIV-1 Env-specific antibodies in mothers and infants predicts reduced vertical transmission

E. Sanders-Buell, M. Robb, G. Ferrari, 2022, Frontiers in Immunology.

Rapid Development of a Mucosal Nanoparticle Flu Vaccine by Genetic Engineering of Bacteriophage T4 using CRISPR-Cas

V. Rao, Wanpo Zhang, Jingen Zhu, 2022, bioRxiv.

Structural analysis of DNA cleaved in vivo by bacteriophage T4 terminase.

V. Rao, S. Bhattacharyya, 1994, Gene.

Nucleotide-dependent DNA gripping and an end-clamp mechanism regulate the bacteriophage T4 viral packaging motor

Douglas E. Smith, V. Rao, Marthandan Mahalingam, 2018, Nature Communications.

Mutations Altering a Structurally Conserved Loop-Helix-Loop Region of a Viral Packaging Motor Change DNA Translocation Velocity and Processivity

Douglas E. Smith, B. T. Andrews, J. Sippy, 2010, The Journal of Biological Chemistry.

A critical coiled coil motif in the small terminase, gp16, from bacteriophage T4: insights into DNA packaging initiation and assembly of packaging motor.

V. Rao, Kiran Kondabagil, 2006, Journal of molecular biology.

Designing a Soluble Near Full-length HIV-1 gp41 Trimer*

V. Polonis, C. Alving, V. Rao, 2012, The Journal of Biological Chemistry.

Defining the ATPase center of bacteriophage T4 DNA packaging machine: requirement for a catalytic glutamate residue in the large terminase protein gp17.

V. Rao, K. Goetzinger, 2003, Journal of molecular biology.

Correlation between Lethal Toxin-Neutralizing Antibody Titers and Protection from Intranasal Challenge with Bacillus anthracis Ames Strain Spores in Mice after Transcutaneous Immunization with Recombinant Anthrax Protective Antigen

S. Leppla, G. Matyas, C. Alving, 2006, Infection and Immunity.

Bacteriophage T4 as a Nanoparticle Platform to Display and Deliver Pathogen Antigens: Construction of an Effective Anthrax Vaccine.

V. Rao, Pan Tao, Qin Li, 2017, Methods in molecular biology.

Anthrax Vaccine Antigen-Adjuvant Formulations Completely Protect New Zealand White Rabbits against Challenge with Bacillus anthracis Ames Strain Spores

G. Matyas, C. Alving, V. Rao, 2011, Clinical and Vaccine Immunology.

Multicomponent anthrax toxin display and delivery using bacteriophage T4.

S. Leppla, G. Matyas, C. Alving, 2007, Vaccine.

Engineering T4 Bacteriophage for In Vivo Display by Type V CRISPR-Cas Genome Editing.

V. Rao, Jingen Zhu, Pan Tao, 2021, ACS synthetic biology.

Unexpected evolutionary benefit to phages imparted by bacterial CRISPR-Cas9

V. Rao, Pan Tao, Xiaorong Wu, 2018, Science Advances.

Structure of the small outer capsid protein, Soc: a clamp for stabilizing capsids of T4-like phages.

M. Rossmann, A. Fokine, L. Qin, 2010, Journal of molecular biology.

Bacteriophage T4 capsid: a unique platform for efficient surface assembly of macromolecular complexes.

Qin Li, Venigalla B Rao, S. Leppla, 2006, Journal of molecular biology.

In vitro binding of anthrax protective antigen on bacteriophage T4 capsid surface through Hoc-capsid interactions: a strategy for efficient display of large full-length proteins.

S. Leppla, G. Matyas, C. Alving, 2006, Virology.

Glycosylation and oligomeric state of envelope protein might influence HIV-1 virion capture by α4β7 integrin.

M. Robb, V. Rao, S. Chand, 2017, Virology.

Quantitative analyses reveal distinct sensitivities of the capture of HIV-1 primary viruses and pseudoviruses to broadly neutralizing antibodies.

M. Robb, N. Michael, V. Rao, 2017, Virology.

Recombinant DNA Principles and Methodologies

J. J. Greene, V. Rao, 2021 .

The N-terminal ATPase site in the large terminase protein gp17 is critically required for DNA packaging in bacteriophage T4.

V. Rao, M. Mitchell, 2001, Journal of molecular biology.

Structure-function analysis of the DNA translocating portal of the bacteriophage T4 packaging machine.

Daisuke Kihara, Michael G Rossmann, Venigalla B Rao, 2014, Journal of molecular biology.

Primary HIV-1 and Infectious Molecular Clones Are Differentially Susceptible to Broadly Neutralizing Antibodies

V. Rao, M. Rao, Jiae Kim, 2020, Vaccines.

Designing a nine cysteine-less DNA packaging motor from bacteriophage T4 reveals new insights into ATPase structure and function.

T. Ha, Bonnie Draper, V. Rao, 2014, Virology.

Altering the speed of a DNA packaging motor from bacteriophage T4

Y. Chemla, V. Rao, Vishal I Kottadiel, 2017, Nucleic acids research.

The dynamic pause-unpackaging state, an off-translocation recovery state of a DNA packaging motor from bacteriophage T4

Y. Chemla, V. Rao, Vishal I Kottadiel, 2012, Proceedings of the National Academy of Sciences.

Novel and deviant Walker A ATP-binding motifs in bacteriophage large terminase-DNA packaging proteins.

V. Rao, M. Mitchell, 2004, Virology.

Functional Analysis of the Bacteriophage T4 DNA-packaging ATPase Motor*

V. Rao, M. Mitchell, 2006, Journal of Biological Chemistry.

DNA Packaging in Bacteriophage T4

L. Black, V. Rao, 2013 .

A bacteriophage T4 DNA packaging related DNA-dependent ATPase-endonuclease.

L. Black, V. Rao, V. Manne, 1982, Journal of Biological Chemistry.

Functional analysis of the DNA-packaging/terminase protein gp17 from bacteriophage T4.

V. Rao, D. Kuebler, 1998, Journal of molecular biology.

Novel mutants in the 5' upstream region of the portal protein gene 20 overcome a gp40-dependent prohead assembly block in bacteriophage T4.

V. Rao, N. Yap, 1996, Journal of molecular biology.

A New Approach to Produce HIV-1 Envelope Trimers

V. Rao, Marthandan Mahalingam, G. Gao, 2015, The Journal of Biological Chemistry.

Functional analysis of the highly antigenic outer capsid protein, Hoc, a virus decoration protein from T4‐like bacteriophages

M. Rossmann, A. Fokine, V. Rao, 2010, Molecular microbiology.

The molecular architecture of the bacteriophage T4 neck.

M. Rossmann, A. Aksyuk, V. Bowman, 2013, Journal of molecular biology.

A genetic shift in an escaped transmitted / founder virus guides 1 combinatorial vaccine design against HIV-1 2 3

Jerome H. Kim, D. Kihara, M. Robb, 2021 .

Structural morphing in a symmetry-mismatched viral vertex

M. Rossmann, A. Fokine, V. Rao, 2020, Nature Communications.

Structure-function Analyses Reveal Key Molecular Determinants of HIV-1 CRF01_AE Resistance to the Entry Inhibitor Temsavir

D. Matthies, Rick Huang, M. Pazgier, 2023, bioRxiv.

A sequestered fusion peptide in the structure of an HIV-1 transmitted founder envelope trimer

M. Rossmann, M. Robb, Zhenguo Chen, 2019, Nature Communications.

The Functional Domains of Bacteriophage T4 Terminase*

M. Rossmann, S. Kanamaru, V. Rao, 2004, Journal of Biological Chemistry.

Structures of a large prolate virus capsid in unexpanded and expanded states generate insights into the icosahedral virus assembly

M. Rossmann, A. Fokine, V. Rao, 2022, Proceedings of the National Academy of Sciences of the United States of America.

T4 bacteriophage nanoparticles engineered through CRISPR provide a versatile platform for rapid development of flu mucosal vaccines.

V. Rao, G. Peng, Wanpo Zhang, 2023, Antiviral research.

The remarkable viral portal vertex: structure and a plausible model for mechanism.

A. Fokine, V. Rao, Q. Fang, 2021, Current opinion in virology.

Structure and Function of Hoc—A Novel Environment Sensing Device Encoded by T4 and Other Bacteriophages

Zhenguo Chen, A. Fokine, V. Rao, 2023, Viruses.

Studies of viral DNA packaging motors with optical tweezers: a comparison of motor function in bacteriophages φ29, λ, and T4

Douglas E. Smith, Derek N. Fuller, Shelley N Grimes, 2007, SPIE NanoScience + Engineering.

Evidence for an electrostatic mechanism of force generation by the bacteriophage T4 DNA packaging motor

Amy D. Migliori, Douglas E. Smith, G. Arya, 2014, Nature Communications.

Cryo-EM structure of T/F100 SOSIP.664 HIV-1 Env trimer in complex with 8ANC195 Fab

M. Rossmann, M. Robb, Zhenguo Chen, 2019 .

Viral Molecular Machines

Michael G. Rossmann, Venigalla B. Rao, M. Rossmann, 2012, Advances in Experimental Medicine and Biology.

Landscape of New Nuclease-Containing Antiphage Systems in Escherichia coli and the Counterdefense Roles of Bacteriophage T4 Genome Modifications

V. Rao, Pan Tao, P. Qian, 2023, Journal of virology.

Mechanisms of DNA Packaging by Large Double-Stranded DNA Viruses.

M. Feiss, V. Rao, 2015, Annual review of virology.

DNA Packaging in Barteriophage T4

L. Black, V. Rao, 2005 .

Functional analysis of the highly antigenic outer capsid protein, Hoc, a virus decoration protein from T4‐like bacteriophages

M. Rossmann, A. Fokine, V. Rao, 2010, Molecular microbiology.

Structure-function analyses reveal key molecular determinants of HIV-1 CRF01_AE resistance to the entry inhibitor temsavir

D. Matthies, M. Pazgier, W. Tolbert, 2023, Nature communications.