Z. Debyser

发表

Diffusion of Myelin Oligodendrocyte Glycoprotein in Living OLN-93 Cells Investigated by Raster-Scanning Image Correlation Spectroscopy (RICS)

Zeger Debyser, Johan Hofkens, Marcel Ameloot, 2008, Journal of Fluorescence.

Post-mitotic BET-induced reshaping of integrase quaternary structure supports wild-type MLV integration

Jelle Hendrix, A. Cereseto, Z. Debyser, 2018, Nucleic acids research.

N-terminal half of transportin SR2 interacts with HIV integrase

Z. Debyser, V. G. Tsirkone, J. Blokken, 2017, The Journal of Biological Chemistry.

Cellular Cofactors of Lentiviral Integrase: From Target Validation to Drug Discovery

Z. Debyser, B. Desimmie, F. Christ, 2012, Molecular biology international.

Transportin-SR2 Imports HIV into the Nucleus

Zeger Debyser, Rik Gijsbers, Richard Benarous, 2008, Current Biology.

Nuclear localization of human immunodeficiency virus type 1 integrase expressed as a fusion protein with green fluorescent protein.

E. De Clercq, P. Cherepanov, Z. Debyser, 1999, Virology.

HIV-1 Integrase Forms Stable Tetramers and Associates with LEDGF/p75 Protein in Human Cells*

Zeger Debyser, Yves Engelborghs, Bart Devreese, 2003, The Journal of Biological Chemistry.

Integrase Mutants Defective for Interaction with LEDGF/p75 Are Impaired in Chromosome Tethering and HIV-1 Replication*

Myriam Witvrouw, Zeger Debyser, Linos Vandekerckhove, 2005, Journal of Biological Chemistry.

The Interaction of LEDGF/p75 with Integrase Is Lentivirus-specific and Promotes DNA Binding*

R. Benarous, J. Vercammen, Z. Debyser, 2005, Journal of Biological Chemistry.

The central DNA flap of the human immunodeficiency virus type 1 is important for viral replication.

Z. Debyser, J. De Rijck, 2006, Biochemical and biophysical research communications.

Measuring protein‐protein interactions inside living cells using single color fluorescence correlation spectroscopy. Application to human immunodeficiency virus type 1 integrase and LEDGF/p75

J. Vercammen, Z. Debyser, Y. Engelborghs, 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Efficient purification and metabolite analysis of radiotracers using high-performance liquid chromatography and on-line solid-phase extraction.

L. Mortelmans, G. Bormans, C. Deroose, 2008, Journal of chromatography. A.

Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication.

A. Marchand, A. Voet, M. de Maeyer, 2010, Nature chemical biology.

Track A Basic Science

S. Sugden, D. Hazuda, F. Pereyra, 2012, Journal of the International AIDS Society.

Identification of the LEDGF/p75 binding site in HIV-1 integrase.

J. Rain, R. Benarous, A. Voet, 2007, Journal of molecular biology.

Potent and highly selective human immunodeficiency virus type 1 (HIV-1) inhibition by a series of alpha-anilinophenylacetamide derivatives targeted at HIV-1 reverse transcriptase.

R. Pauwels, A. Vandamme, E. Clercq, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Design, synthesis, and biological evaluation of a series of 2-hydroxyisoquinoline-1,3(2H,4H)-diones as dual inhibitors of human immunodeficiency virus type 1 integrase and the reverse transcriptase RNase H domain.

F. Bailly, J. Mouscadet, Z. Debyser, 2008, Journal of medicinal chemistry.

Phage display-directed discovery of LEDGF/p75 binding cyclic peptide inhibitors of HIV replication.

M. Humbert, U. Dietrich, Jelle Hendrix, 2012, Molecular therapy : the journal of the American Society of Gene Therapy.

Targeting integration beyond strand transfer: development of second-generation HIV integrase inhibitors

A. Voet, Z. Debyser, F. Christ, 2011 .

In search of second-generation HIV integrase inhibitors: targeting integration beyond strand transfer.

A. Voet, Z. Debyser, F. Christ, 2009, Future medicinal chemistry.

Rational Design, Synthesis and Evaluation of Coumarin Derivatives as Protein‐protein Interaction Inhibitors

Z. Debyser, F. Christ, S. Ferro, 2016, Molecular informatics.

Pharmacophore‐Based Discovery of Small‐Molecule Inhibitors of Protein–Protein Interactions between HIV‐1 Integrase and Cellular Cofactor LEDGF/p75

Z. Debyser, F. Christ, S. Ferro, 2009, ChemMedChem.

Optimization of rhodanine scaffold for the development of protein-protein interaction inhibitors.

Z. Debyser, F. Christ, S. Ferro, 2015, Bioorganic & medicinal chemistry.

Diketoacid chelating ligands as dual inhibitors of HIV-1 integration process.

N. Neamati, Z. Debyser, F. Christ, 2014, European journal of medicinal chemistry.

A new potential approach to block HIV-1 replication via protein-protein interaction and strand-transfer inhibition.

Z. Debyser, F. Christ, S. Ferro, 2014, Bioorganic & medicinal chemistry.

Fragment hopping approach directed at design of HIV IN-LEDGF/p75 interaction inhibitors

Z. Debyser, F. Christ, S. Ferro, 2013, Journal of enzyme inhibition and medicinal chemistry.

New scaffolds of natural origin as Integrase-LEDGF/p75 interaction inhibitors: virtual screening and activity assays.

Z. Debyser, F. Christ, S. Ferro, 2013, European journal of medicinal chemistry.

Discovery of novel inhibitors of LEDGF/p75-IN protein-protein interactions.

T. Sanchez, N. Neamati, Z. Debyser, 2013, Bioorganic & medicinal chemistry.

A Symmetric Region of the HIV-1 Integrase Dimerization Interface Is Essential for Viral Replication

Erik Serrao, N. Neamati, Laith Q. Al‐Mawsawi, 2012, PloS one.

Small molecules targeting protein-protein interactions: A promising anti-HIV strategy

Z. Debyser, F. Christ, S. Ferro, 2010 .

Small molecules targeting the interaction between HIV-1 integrase and LEDGF/p75 cofactor.

Zeger Debyser, Alba Chimirri, Rosaria Gitto, 2010, Bioorganic & medicinal chemistry.

Inhibitory profile of a LEDGF/p75 peptide against HIV‐1 integrase: Insight into integrase–DNA complex formation and catalysis

Zeger Debyser, Nouri Neamati, Frauke Christ, 2008, FEBS letters.

Docking studies on a new human immunodeficiency virus integrase-Mg-DNA complex: phenyl ring exploration and synthesis of 1H-benzylindole derivatives through fluorine substitutions.

Z. Debyser, F. Christ, M. Witvrouw, 2009, Journal of medicinal chemistry.

The fetal respiratory system as target for antenatal therapy

K. Devriendt, R. Devlieger, M. Carlon, 2011, Facts, views & vision in ObGyn.

The fetal patient – ethical aspects of fetal therapy

J. Deprest, L. Lewi, R. Devlieger, 2011, Facts, views & vision in ObGyn.

Non-invasive imaging of neuropathology in a rat model of α-synuclein overexpression

J. Nuyts, L. Mortelmans, G. Bormans, 2007, Neurobiology of Aging.

Positional effects of the central DNA flap in HIV-1-derived lentiviral vectors.

Z. Debyser, B. Van Maele, J. De Rijck, 2005, Biochemical and biophysical research communications.

Expression of HIV‐1 integrase in CEM cells inhibits HIV‐1 replication

E. De Clercq, P. Cherepanov, J. van Griensven, 2004, The journal of gene medicine.

In Search of Authentic Inhibitors of HIV-1 Integration

E. De Clercq, P. Cherepanov, Z. Debyser, 2002, Antiviral chemistry & chemotherapy.

New tetrahydroimidazo[4,5,1-jk][1,4]-benzodiazepin-2(1H)-one and -thione derivatives are potent inhibitors of human immunodeficiency virus type 1 replication and are synergistic with 2',3'-dideoxynucleoside analogs

E. De Clercq, R. Pauwels, Z. Debyser, 1994, Antimicrobial Agents and Chemotherapy.

New [4,5,1-JK][1,4]benzodiazepin-2(1H)-one and -thione derivatives are potent inhibitors of human immunodeficiency virus type 1 and are synergistic with 2',3'-dideoxynucleoside analogs

R. Pauwels, E. Clercq, Z. Debyser, 1994 .

Depletion of PINK1 affects mitochondrial metabolism, calcium homeostasis and energy maintenance

R. Rodenburg, V. Baekelandt, G. Callewaert, 2011, Journal of Cell Science.

Affinity switching of the LEDGF/p75 IBD interactome is governed by kinase-dependent phosphorylation

V. Veverka, M. Hubálek, K. Cermakova, 2018, Proceedings of the National Academy of Sciences.

Integrase as a Novel Target for the Inhibition of Human Immunodeficiency Virus Type 1 Infection: Current Status and Future Perspectives

J. Schapiro, A. Voet, Z. Debyser, 2009 .

Overexpression of the Lens Epithelium-Derived Growth Factor/p75 Integrase Binding Domain Inhibits Human Immunodeficiency Virus Replication

Jelle Hendrix, J. Vercammen, R. Gijsbers, 2006, Journal of Virology.

Hematopoietic stem cell-based gene therapy against HIV infection: promises and caveats.

E. De Clercq, J. van Griensven, Z. Debyser, 2005, AIDS reviews.

HIV-1 integration: an interplay between HIV-1 integrase, cellular and viral proteins.

Z. Debyser, B. Van Maele, 2005, AIDS reviews.

Bioluminescence imaging of stroke-induced endogenous neural stem cell response

M. Hoehn, K. Laere, V. Baekelandt, 2014, Neurobiology of Disease.

The chromatin landscape at the HIV-1 provirus integration site determines viral expression

Guillaume J. Filion, E. Zorita, G. Filion, 2020, Nucleic acids research.

Impact of LEDGIN treatment during virus production on residual HIV-1 transcription

R. Gijsbers, Z. Debyser, Irena Zurnić, 2019, Retrovirology.

Interaction of the HIV-1 Intasome with Transportin 3 Protein (TNPO3 or TRN-SR2)*

Zeger Debyser, Mark P Foster, Frauke Christ, 2012, The Journal of Biological Chemistry.

Microwave‐Assisted Palladium‐Catalyzed Heterogeneous Vinylation of 2(1H)‐Pyridones

E. V. D. Eycken, V. S. Parmar, Z. Debyser, 2009 .

Four-tiered pi interaction at the dimeric interface of HIV-1 integrase critical for DNA integration and viral infectivity.

R. Dayam, N. Neamati, Laith Q. Al‐Mawsawi, 2008, Virology.

env Chimeric Virus Technology for Evaluating Human Immunodeficiency Virus Susceptibility to Entry Inhibitors

E. De Clercq, C. Pannecouque, A. Vandamme, 2002, Antimicrobial Agents and Chemotherapy.

Formation of a DNA Loop at the Replication Fork Generated by Bacteriophage T7 Replication Proteins*

J. Griffith, Z. Debyser, C. Richardson, 1998, The Journal of Biological Chemistry.

Coordination of leading and lagging strand DNA synthesis at the replication fork of bacteriophage T7

Z. Debyser, C. Richardson, S. Tabor, 1994, Cell.

HIV-1 integrase variants retarget viral integration and are associated with disease progression in a chronic infection cohort.

T. Ndung’u, M. de Maeyer, R. Gijsbers, 2014, Cell host & microbe.

The BET family of proteins targets moloney murine leukemia virus integration near transcription start sites.

F. Bushman, S. Husson, Nirav Malani, 2013, Cell reports.

High-resolution profiling of the LEDGF/p75 chromatin interaction in the ENCODE region

H. Ceulemans, R. Gijsbers, Z. Debyser, 2009, Nucleic acids research.

LEDGINs inhibit late stage HIV-1 replication by modulating integrase multimerization in the virions

C. Weydert, N. Bannert, J. Hofkens, 2013, Retrovirology.

HIV-1 integrase inhibition: looking at cofactor interactions.

Z. Debyser, F. Christ, 2015, Future medicinal chemistry.

Comparative Analysis of HIV-1 and Murine Leukemia Virus Three-Dimensional Nuclear Distributions

L. Mulder, A. Cereseto, R. Gijsbers, 2016, Journal of Virology.

Role of the PWWP domain of lens epithelium-derived growth factor (LEDGF)/p75 cofactor in lentiviral integration targeting.

F. Bushman, Nirav Malani, R. Gijsbers, 2018, The Journal of Biological Chemistry.

Investigation of a novel series of 2-hydroxyisoquinoline-1,3(2H,4H)-diones as human immunodeficiency virus type 1 integrase inhibitors.

F. Bailly, Z. Debyser, C. Calmels, 2014, Journal of medicinal chemistry.

Differential interaction of HIV-1 integrase and JPO2 with the C terminus of LEDGF/p75.

R. Benarous, R. Gijsbers, Z. Debyser, 2007, Journal of molecular biology.

Lens Epithelium-derived Growth Factor/p75 Interacts with the Transposase-derived DDE Domain of PogZ*

J. Rain, R. Benarous, Jelle Hendrix, 2009, Journal of Biological Chemistry.

The Stress Oncoprotein LEDGF/p75 Interacts with the Methyl CpG Binding Protein MeCP2 and Influences Its Transcriptional Activity

Sandy S. Tungteakkhun, Z. Debyser, F. Christ, 2012, Molecular Cancer Research.

Impairing MLL-fusion gene-mediated transformation by dissecting critical interactions with the lens epithelium-derived growth factor (LEDGF/p75)

K. Cermakova, R. Gijsbers, Z. Debyser, 2013, Leukemia.

Engineering Next-Generation BET-Independent MLV Vectors for Safer Gene Therapy

R. Gijsbers, Z. Debyser, J. Demeulemeester, 2017, Molecular therapy. Nucleic acids.

Synthesis and antiviral properties of some polyphenols related to Salvia genus.

F. Bailly, J. Mouscadet, Z. Debyser, 2008, Bioorganic & medicinal chemistry letters.

Antiviral resistance to diketo acids is associated with the mutations T66I, L74M and S230R in the HIV-1 integrase gene

C. Pannecouque, N. Neamati, T. Burke, 2002 .

Rilpivirine: a step forward in tailored HIV treatment

Z. Debyser, B. Desimmie, R. Schrijvers, 2011, The Lancet.

Potent and selective inhibition of human immunodeficiency virus (HIV)-1 and HIV-2 replication by a class of bicyclams interacting with a viral uncoating event.

E. De Clercq, R. Pauwels, M. Baba, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Synthesis, in vitro and in vivo evaluation of fluorine-18 labelled FE-GW405833 as a PET tracer for type 2 cannabinoid receptor imaging.

G. Bormans, V. Baekelandt, K. Van Laere, 2011, Bioorganic & medicinal chemistry.

Assays for evaluation of HIV-1 integrase enzymatic activity, DNA binding, and cofactor interaction

Jelle Hendrix, Z. Debyser, Y. Engelborghs, 2011 .

Activity of recombinant HIV-1 integrase on mini-HIV DNA.

E. De Clercq, J. Griffith, P. Cherepanov, 1999, Nucleic Acids Research.

Mode of interaction of G-quartets with the integrase of human immunodeficiency virus type 1.

E. De Clercq, P. Cherepanov, G. Reekmans, 1997, Molecular pharmacology.

Long‐term reversal of diabetes in non‐obese diabetic mice by liver‐directed gene therapy

M. Wei, N. Nassif, A. Simpson, 2013, The journal of gene medicine.

Galectin-1 in melanoma biology and related neo-angiogenesis processes.

T. Mohr, R. Kiss, O. Feron, 2012, The Journal of investigative dermatology.

Selected talk 2 MCMV exploits the spleen as a transfer hub for systemic dissemination upon oronasal inoculation

W. Fiers, G. Wilkie, B. Graham, 2015 .

Hope for non-responders with hepatitis C virus and cirrhosis

Z. Debyser, 2015 .

High-content analysis of α-synuclein aggregation and cell death in a cellular model of Parkinson's disease

V. Baekelandt, S. Munck, H. Pottel, 2016, Journal of Neuroscience Methods.

Switching STRATEGIES in HIV treatment.

Z. Debyser, R. Schrijvers, 2014, The Lancet. Infectious diseases.

Quad's in it for antiretroviral therapy?

Z. Debyser, R. Schrijvers, 2012, The Lancet.

Comparison of lentiviral vector titration methods

V. Baekelandt, R. Gijsbers, Z. Debyser, 2006, BMC biotechnology.

Upscaling of lentiviral vector production by tangential flow filtration

V. Baekelandt, R. Gijsbers, Z. Debyser, 2005, The journal of gene medicine.

Propargylated Purine Deoxynucleosides: New Tools for Fluorescence Imaging Strategies

A. Venkatesham, Z. Debyser, A. Van Aerschot, 2019, Molecules.

Parkin protects against neurotoxicity in the 6-hydroxydopamine rat model for Parkinson's disease.

V. Baekelandt, C. Van den Haute, R. Gijsbers, 2006, Molecular therapy : the journal of the American Society of Gene Therapy.

Toward the Discovery of Novel Anti‐HIV Drugs. Second‐Generation Inhibitors of the Cellular ATPase DDX3 with Improved Anti‐HIV Activity: Synthesis, Structure–Activity Relationship Analysis, Cytotoxicity Studies, and Target Validation

F. Baldanti, M. Radi, S. Zanoli, 2011, ChemMedChem.

Lessons Learned: HIV Points the Way Towards Precision Treatment of Mixed-Lineage Leukemia.

C. Weydert, K. Cermakova, Z. Debyser, 2016, Trends in pharmacological sciences.

Synthesis and biological evaluation of (11)C-labeled beta-galactosyl triazoles as potential PET tracers for in vivo LacZ reporter gene imaging.

L. Mortelmans, G. Bormans, T. D. de Groot, 2009, Bioorganic & medicinal chemistry.

Gene therapeutic strategies for neurodegenerative diseases.

B. de Strooper, B. Nuttin, V. Baekelandt, 2000, Current opinion in molecular therapeutics.

Efficient gene transfer into the mouse lung by fetal intratracheal injection of rAAV2/6.2.

V. Baekelandt, U. Himmelreich, J. Deprest, 2010, Molecular therapy : the journal of the American Society of Gene Therapy.

IMMUNISATION OF AFRICAN PRETEEN / ADOLESCENT GIRLS AND YOUNG WOMEN WITH THE HPV-16 / 18 AS 04-ADJUVANTED VACCINE

Roberta, J. Deprest, M. Carlon, 2011 .

Highly potent and selective inhibition of human immunodeficiency virus by the bicyclam derivative JM3100

E. De Clercq, R. Pauwels, B. Rosenwirth, 1994, Antimicrobial Agents and Chemotherapy.

Evaluation of LV and AAV vector systems for stable delivery of MRI reporter genes to the rodent brain

T. Dresselaers, V. Baekelandt, U. Himmelreich, 2009 .

Fk506&reduces&neuroinflammation&and&dopaminergic& Neurodegeneration&in&an&α8synuclein8based&rat&model&for& Parkinson's&disease.% Fk506 Reduces Neuroinflammation and Dopaminergic Neurodegeneration in an - Synuclein-based Rat Model for Parkinson's Disease Authors

V. Baekelandt, C. Van den Haute, M. Carlon, 2022 .

Analysis of ex vivo HIV-1 infection in a controller-discordant couple

K. Van Laethem, R. Gijsbers, Z. Debyser, 2018, Journal of virus eradication.

Quantitative assessment of gene-based versus particle based MRI contrast agents for progenitor cell tracking in rodent brain

Zeger Debyser, Frederik Maes, Tom Dresselaers, 2010 .

Quantitative evaluation of MRI-based tracking of ferritin-labeled endogenous neural stem cell progeny in rodent brain

Zeger Debyser, Frederik Maes, Annemarie van der Linden, 2012, NeuroImage.

Bioluminescence Imaging of Stroke-1 Induced Endogenous Neural Stem

M. Hoehn, K. Laere, V. Baekelandt, 2014 .

Seeing genes at work in the living brain with non-invasive molecular imaging.

V. Baekelandt, C. Deroose, Z. Debyser, 2009, Current gene therapy.

Expansion microscopy allows high resolution single cell analysis of epigenetic readers

T. Voet, J. Hofkens, Susana Rocha, 2022, Nucleic acids research.

A novel surgical approach for intratracheal administration of bioactive agents in a fetal mouse model.

J. Nuyts, U. Himmelreich, J. Deprest, 2012, Journal of visualized experiments : JoVE.

Efficient and stable transduction of dopaminergic neurons in rat substantia nigra by rAAV 2/1, 2/2, 2/5, 2/6.2, 2/7, 2/8 and 2/9

F. Coun, V. Baekelandt, J. Wilson, 2011, Gene Therapy.

Noninvasive Imaging Reveals Stable Transgene Expression in Mouse Airways After Delivery of a Nonintegrating Recombinant Adeno-Associated Viral Vector.

V. Baekelandt, A. Liston, D. Vidovic, 2016, Human gene therapy.

Immunological ignorance allows long-term gene expression after perinatal recombinant adeno-associated virus-mediated gene transfer to murine airways.

V. Baekelandt, J. Deprest, A. Liston, 2014, Human gene therapy.

Immunological ignorance allows long-term gene expression following perinatal rAAV-mediated gene transfer to murine airways

V. Baekelandt, J. Deprest, A. Liston, 2013 .

Failure to quantify viral load with two of the three commercial methods in a pregnant woman harboring an HIV type 1 subtype G strain.

E. De Clercq, A. Vandamme, K. Van Laethem, 1998, AIDS research and human retroviruses.

Human immunodeficiency virus glycoprotein gp120 as the primary target for the antiviral action of AR177 (Zintevir).

E. De Clercq, C. Pannecouque, B. Clotet, 1998, Molecular pharmacology.

LEDGF/p75-mediated chemoresistance of mixed-lineage leukemia involves cell survival pathways and super enhancer activators

G. Nigita, A. Canella, M. Carlon, 2021, Cancer Gene Therapy.

DNA substrates for studying replication mechanisms: synthetic replication forks.

Z. Debyser, 1995, Methods in enzymology.

Mutations in Both env and gag genes are required for HIV-1 resistance to the polysulfonic dendrimer SPL2923, as corroborated by chimeric virus technology

E. De Clercq, A. Vandamme, Z. Debyser, 2005, Antiviral chemistry & chemotherapy.

env Chimeric Virus Technology for Evaluating Human Immunodeficiency Virus Susceptibility to Entry Inhibitors

C. Pannecouque, A. Vandamme, K. Van Laethem, 2003, Antimicrobial Agents and Chemotherapy.

Magnesium chelating 2-hydroxyisoquinoline-1,3(2H,4H)-diones, as inhibitors of HIV-1 integrase and/or the HIV-1 reverse transcriptase ribonuclease H domain: discovery of a novel selective inhibitor of the ribonuclease H function.

F. Bailly, H. Vezin, Z. Debyser, 2011, Journal of medicinal chemistry.

An antiviral target on reverse transcriptase of human immunodeficiency virus type 1 revealed by tetrahydroimidazo-[4,5,1-jk] [1,4]benzodiazepin-2 (1H)-one and -thione derivatives.

E. De Clercq, R. Pauwels, Z. Debyser, 1991, Proceedings of the National Academy of Sciences of the United States of America.

2-hydroxyisoquinoline-1,3(2H,4H)-diones as inhibitors of HIV-1 integrase and reverse transcriptase RNase H domain: influence of the alkylation of position 4.

F. Bailly, Z. Debyser, C. Calmels, 2011, European journal of medicinal chemistry.

Mutations in Human Immunodeficiency Virus Type 1 Integrase Confer Resistance to the Naphthyridine L-870,810 and Cross-Resistance to the Clinical Trial Drug GS-9137

A. Voet, M. de Maeyer, Z. Debyser, 2008, Antimicrobial Agents and Chemotherapy.

Preclinical Evaluation of a P2X7 Receptor–Selective Radiotracer: PET Studies in a Rat Model with Local Overexpression of the Human P2X7 Receptor and in Nonhuman Primates

W. Vanduffel, G. Bormans, X. Langlois, 2016, The Journal of Nuclear Medicine.

PET imaging of TSPO in a rat model of local neuroinflammation induced by intracerebral injection of lipopolysaccharide.

G. Bormans, T. Dresselaers, A. Planas, 2015, Nuclear medicine and biology.

High‐level expression of active HIV‐1 integrase from a synthetic gene in human cells

P. Proost, P. Cherepanov, E. Clercq, 2000, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

A short course on virology / vectorology / gene therapy.

Z. Debyser, 2003, Current gene therapy.

Toward novel HIV-1 integrase binding inhibitors: molecular modeling, synthesis, and biological studies.

C. Tintori, M. Botta, Z. Debyser, 2007, Bioorganic & medicinal chemistry letters.

Assays for the evaluation of HIV-1 integrase inhibitors.

E. De Clercq, Z. Debyser, W. Pluymers, 2001, Methods in molecular biology.

Preclinical evaluation of [11C]NE40, a type 2 cannabinoid receptor PET tracer.

G. Bormans, R. Sciot, V. Baekelandt, 2012, Nuclear medicine and biology.

Evaluation of the expression pattern of rAAV2/1, 2/5, 2/7, 2/8, and 2/9 serotypes with different promoters in the mouse visual cortex

L. Arckens, V. Baekelandt, C. Van den Haute, 2015, The Journal of comparative neurology.

Lens epithelium-derived growth factor/p75 qualifies as a target for HIV gene therapy in the NSG mouse model.

R. Gijsbers, Z. Debyser, D. von Laer, 2012, Molecular therapy : the journal of the American Society of Gene Therapy.

BET-Independent Murine Leukemia Virus Integration Is Retargeted In Vivo and Selects Distinct Genomic Elements for Lymphomagenesis

R. Gijsbers, Z. Debyser, F. Christ, 2022, Microbiology spectrum.

Scientific program

Z. Debyser, J. Desmyter, P. Janssen, 2008, Journal of Clinical Virology.

Identification of Novel 3-Hydroxy-pyran-4-One Derivatives as Potent HIV-1 Integrase Inhibitors Using in silico Structure-Based Combinatorial Library Design Approach

A. Fassihi, L. Saghaie, Simone Brogi, 2019, Front. Chem..

The Stress Oncoprotein LEDGF/p75 Interacts with the Methyl CpG Binding Protein MeCP2 and Influences Its Transcriptional Activity

Sandy S. Tungteakkhun, Z. Debyser, F. Christ, 2012, Molecular Cancer Research.

Regulator of G‐protein signaling 18 controls megakaryopoiesis and the cilia‐mediated vertebrate mechanosensory system

R. Gijsbers, Z. Debyser, J. Metz, 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Single-Cell Imaging Shows That the Transcriptional State of the HIV-1 Provirus and Its Reactivation Potential Depend on the Integration Site

Z. Debyser, N. Parveen, F. De Wit, 2022, mBio.

Inhibition of Human Immunodeficiency Virus Type 1 Integration by Diketo Derivatives

E. De Clercq, C. Pannecouque, N. Neamati, 2002, Antimicrobial Agents and Chemotherapy.

A Versatile and Practical Synthesis toward the Development of Novel HIV‐1 Integrase Inhibitors

C. Tintori, G. Vignaroli, M. Botta, 2011, ChemMedChem.

Biosafety of lentiviral vectors.

Z. Debyser, 2003, Current gene therapy.

Investigations on the 4-quinolone-3-carboxylic acid motif. 1. Synthesis and structure-activity relationship of a class of human immunodeficiency virus type 1 integrase inhibitors.

C. Tintori, M. Botta, Z. Debyser, 2008, Journal of medicinal chemistry.

Synthesis of New Potential HIV-1 Integrase Inhibitors

Z. Debyser, M. Witvrouw, S. Ferro, 2004 .

Block-And-Lock Strategies to Cure HIV Infection

Z. Debyser, Gerlinde Vansant, Anne Bruggemans, 2020, Viruses.

New 4‐[(1‐Benzyl‐1H‐indol‐3‐yl)carbonyl]‐3‐hydroxyfuran‐2(5H)‐ones, β‐Diketo Acid Analogs as HIV‐1 Integrase Inhibitors

Z. Debyser, M. Witvrouw, S. Ferro, 2007, Archiv der Pharmazie.

4-Substituted 2-Hydroxyisoquinoline-1,3(2H,4H)-diones as a Novel Class of HIV-1 Integrase Inhibitors.

F. Bailly, Z. Debyser, C. Calmels, 2013, ACS medicinal chemistry letters.

Selection of human immunodeficiency virus type 1 resistance against the pyranodipyrimidine V-165 points to a multimodal mechanism of action.

J. Vercammen, Z. Debyser, Y. Engelborghs, 2007, The Journal of antimicrobial chemotherapy.

Identification of Authentic Inhibitors of HIV-1 Integration

J. Vercammen, Z. Debyser, Y. Engelborghs, 2005 .

Novel inhibitors of HIV-1 integration.

C. Pannecouque, J. Vercammen, Z. Debyser, 2004, Current drug metabolism.

Pharmacophore-based design of HIV-1 integrase strand-transfer inhibitors.

Myriam Witvrouw, Zeger Debyser, Angela Rao, 2005, Journal of medicinal chemistry.

HIV-1 Integrase Drug Discovery Comes of Age

Z. Debyser, J. Demeulemeester, M. Maeyer, 2013 .

Quinolone 3-carboxylic acid pharmacophore: design of second generation HIV-1 integrase inhibitors.

Myriam Witvrouw, Zeger Debyser, Laith Q Al-Mawsawi, 2008, Journal of medicinal chemistry.

N-aminoimidazole derivatives inhibiting retroviral replication via a yet unidentified mode of action.

E. De Clercq, C. Pannecouque, P. Herdewijn, 2003, Journal of medicinal chemistry.

Discovery of novel non-cytotoxic salicylhydrazide containing HIV-1 integrase inhibitors.

R. Dayam, N. Neamati, Laith Q. Al‐Mawsawi, 2007, Bioorganic & medicinal chemistry letters.

Preliminary validation of varicella zoster virus thymidine kinase as a novel reporter gene for PET.

J. Nuyts, L. Mortelmans, G. Bormans, 2012, Nuclear medicine and biology.

Preclinical Evaluation of 1H-Benzylindole Derivatives as Novel Human Immunodeficiency Virus Integrase Strand Transfer Inhibitors

L. Vrang, Z. Debyser, F. Christ, 2008, Antimicrobial Agents and Chemotherapy.

A refined pharmacophore model for HIV-1 integrase inhibitors: Optimization of potency in the 1H-benzylindole series.

Myriam Witvrouw, Zeger Debyser, Alba Chimirri, 2008, Bioorganic & medicinal chemistry letters.

Microwave-assisted synthesis of fluoroquinolones and their nucleosides as inhibitors of HIV integrase

J. Bats, Z. Debyser, M. Witvrouw, 2006 .

Exploration of novel thiobarbituric acid-, rhodanine- and thiohydantoin-based HIV-1 integrase inhibitors.

C. Tintori, M. Botta, Z. Debyser, 2009, Bioorganic & medicinal chemistry letters.

New chloro,fluorobenzylindole derivatives as integrase strand-transfer inhibitors (INSTIs) and their mode of action.

Z. Debyser, F. Christ, S. Ferro, 2010, Bioorganic & medicinal chemistry.

Synthesis and antiviral properties of some polyphenols related to Salvia genus.

F. Bailly, J. Mouscadet, Z. Debyser, 2008, Bioorganic & medicinal chemistry letters.

SRR-SB3, a disulfide-containing macrolide that inhibits a late stage of the replicative cycle of human immunodeficiency virus

E. De Clercq, C. Pannecouque, A. Vandamme, 1997, Antimicrobial agents and chemotherapy.

Unraveling the Role of Peptidyl-Prolyl Isomerases in Neurodegeneration

V. Baekelandt, Z. Debyser, J. Demeulemeester, 2011, Molecular Neurobiology.

Mechanism of anti-human immunodeficiency virus action of polyoxometalates, a class of broad-spectrum antiviral agents.

E. De Clercq, R. Pauwels, M. Hosoya, 1992, Molecular pharmacology.

Synthesis, anti-HIV-1 and antiproliferative evaluation of novel 4-nitroimidazole derivatives combined with 5-hydroxy-4-pyridinone moiety

A. Fassihi, L. Saghaie, Z. Debyser, 2020 .

Synthesis and biological evaluation of novel antiviral agents as protein–protein interaction inhibitors

Zeger Debyser, Alba Chimirri, Rosaria Gitto, 2014, Journal of enzyme inhibition and medicinal chemistry.

4-[1-(4-Fluorobenzyl)-4-hydroxy-1H-indol-3-yl]-2-hydroxy-4-oxobut-2-enoic acid as a prototype to develop dual inhibitors of HIV-1 integration process.

Zeger Debyser, Alba Chimirri, Rosaria Gitto, 2011, Antiviral research.

New 4‐[(1‐Benzyl‐1H‐indol‐3‐yl)carbonyl]‐3‐hydroxyfuran‐2(5H)‐ones, β‐Diketo Acid Analogues as HIV‐1 Integrase Inhibitors.

Z. Debyser, M. Witvrouw, S. Ferro, 2007 .

Efficient 3D Database Screening for Novel HIV-1 IN Inhibitors

Myriam Witvrouw, Zeger Debyser, M. Letizia Barreca, 2004, J. Chem. Inf. Model..

Design, Synthesis and antiHIV activity of Novel Isatine-Sulphonamides

Z. Debyser, M. Witvrouw, P. Selvam, 2008, Indian journal of pharmaceutical sciences.

Synthesis, Molecular Modelling and Biological Studies of 3-hydroxy-pyrane-4-one and 3-hydroxy-pyridine-4-one Derivatives as HIV-1 Integrase Inhibitors.

Zeger Debyser, Afshin Fassihi, Simone Brogi, 2018, Medicinal chemistry (Shariqah (United Arab Emirates)).

Reaction of rosmarinic acid with nitrite ions in acidic conditions: discovery of nitro- and dinitrorosmarinic acids as new anti-HIV-1 agents.

F. Bailly, J. Mouscadet, Z. Debyser, 2008, Journal of medicinal chemistry.

Determinants of Retroviral Integration and Implications for Gene Therapeutic MLV—Based Vectors and for a Cure for HIV-1 Infection

Z. Debyser, F. Christ, Anayat Bhat, 2022, Viruses.

Host factors for retroviral integration site selection.

R. Gijsbers, Z. Debyser, F. Christ, 2015, Trends in biochemical sciences.

BET-independent MLV-based Vectors Target Away From Promoters and Regulatory Elements

K. Cermakova, R. Gijsbers, Z. Debyser, 2014, Molecular therapy. Nucleic acids.

Insight in HIV Integration Site Selection Provides a Block-and-Lock Strategy for a Functional Cure of HIV Infection

Z. Debyser, F. Christ, Gerlinde Vansant, 2018, Viruses.

Inhibition of visna virus replication and cytopathic effect in sheep choroid plexus cell cultures by selected anti-HIV agents.

E. De Clercq, J. Balzarini, Z. Debyser, 1995, Antiviral research.

2-Hydroxyisoquinoline-1,3(2H,4H)-diones (HIDs), novel inhibitors of HIV integrase with a high barrier to resistance.

F. Bailly, Z. Debyser, B. Desimmie, 2013, ACS chemical biology.

Inhibition of visna virus replication by 2',3'-dideoxynucleosides and acyclic nucleoside phosphonate analogs

E. De Clercq, J. Balzarini, Z. Debyser, 1993, Antimicrobial Agents and Chemotherapy.

Specific HIV-1 reverse transcriptase inhibitors.

E. De Clercq, R. Pauwels, Z. Debyser, 1992, Journal of enzyme inhibition.

Proceedings of the Frontiers of Retrovirology Conference 2016

R. König, D. Elleder, R. Sachidanandam, 2016, Retrovirology.

Development of a series of 3-hydroxyquinolin-2(1H)-ones as selective inhibitors of HIV-1 reverse transcriptase associated RNase H activity.

F. Bailly, Z. Debyser, F. Christ, 2012, Bioorganic & medicinal chemistry letters.

Design, synthesis, in silico studies, and antiproliferative evaluations of novel indolin-2-one derivatives containing 3-hydroxy-4-pyridinone fragment.

A. Fassihi, L. Saghaie, Z. Debyser, 2022, Bioorganic & medicinal chemistry letters.

Discovery of a novel 5-carbonyl-1H-imidazole-4-carboxamide class of inhibitors of the HIV-1 integrase-LEDGF/p75 interaction.

Erik Serrao, N. Neamati, Z. Debyser, 2013, Bioorganic & medicinal chemistry.

Fragment-based discovery of 8-hydroxyquinoline inhibitors of the HIV-1 integrase-lens epithelium-derived growth factor/p75 (IN-LEDGF/p75) interaction.

Zeger Debyser, Nouri Neamati, Frauke Christ, 2013, Journal of medicinal chemistry.

Alternative Splicing and Caspase-Mediated Cleavage Generate Antagonistic Variants of the Stress Oncoprotein LEDGF/p75

R. Gijsbers, Z. Debyser, M. Filippova, 2008, Molecular Cancer Research.

Alternative Splicing and Caspase-Mediated Cleavage Generate Antagonistic Variants of the Stress Oncoprotein LEDGF / p 75

R. Gijsbers, Z. Debyser, M. Filippova, 2008 .

A two plasmid co-expression system in Escherichia coli for the production of virion-like reverse transcriptase of the human immunodeficiency virus type 1.

E. De Clercq, J. Vandekerckhove, J. Balzarini, 1996, Journal of virological methods.

Design and discovery of 5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxamide inhibitors of HIV-1 integrase.

N. Neamati, Yang Liu, Daoguang Zhang, 2014, Bioorganic & medicinal chemistry.

Development of an AlphaScreen-Based HIV-1 Integrase Dimerization Assay for Discovery of Novel Allosteric Inhibitors

C. Tintori, M. Botta, Z. Debyser, 2012, Journal of biomolecular screening.

Alpba-Oligodeoxynucleotides as Inhibitors of HIV Reverse Transcriptase

R. Pauwels, M. Baba, J. Balzarini, 1989 .

Small-Molecule Inhibitors of the LEDGF/p75 Binding Site of Integrase Block HIV Replication and Modulate Integrase Multimerization

Stephen M. Shaw, A. Marchand, S. Butler, 2012, Antimicrobial Agents and Chemotherapy.

Multimerizationand Modulate Integrase Binding Site of Integrase Block HIV Small-Molecule Inhibitors of the LEDGF/p75

Stephen M. Shaw, A. Marchand, Z. Debyser, 2012 .

Combinational therapies for HIV: a focus on EVG/COBI/FTC/TDF

Z. Debyser, R. Schrijvers, 2012, Expert opinion on pharmacotherapy.

Characterization of HIV-1 strains isolated from patients treated with TIBO R82913.

B. Gazzard, R. Pauwels, M. Youle, 1994, AIDS research and human retroviruses.

Polyanionic (i.e., polysulfonate) dendrimers can inhibit the replication of human immunodeficiency virus by interfering with both virus adsorption and later steps (reverse transcriptase/integrase) in the virus replicative cycle.

E. De Clercq, C. Pannecouque, E. Clercq, 2000, Molecular pharmacology.

Insight into HIV-2 latency may disclose strategies for a cure for HIV-1 infection

R. Gijsbers, Z. Debyser, F. Christ, 2017, Journal of virus eradication.

Chemical crosslinking of the subunits of HIV‐1 reverse transcriptase

E. De Clercq, Z. Debyser, 1996, Protein science : a publication of the Protein Society.

Novel targets for HIV therapy.

W. Greene, E. Freed, Y. Ikeda, 2008, Antiviral research.

Common features in the interaction of tetrahydroimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-one and -thione and 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine derivatives with the human immunodeficiency virus type 1 reverse transcriptase.

E. De Clercq, R. Pauwels, M. Baba, 1992, Molecular pharmacology.

State-of-the-art lentiviral vectors for research use: risk assessment and biosafety recommendations.

Zeger Debyser, Rik Gijsbers, Jaan Toelen, 2009, Current gene therapy.

SRR-SB 3 , a Disulfide-Containing Macrolide That Inhibits a Late Stage of the Replicative Cycle of Human Immunodeficiency Virus

C. Pannecouque, A. Vandamme, J. Balzarini, 1997 .

BET-independent MLV integration is retargeted in vivo and selects distinct genomic elements for lymphomagenesis

R. Gijsbers, Z. Debyser, F. Christ, 2022, bioRxiv.

Lentiviral nuclear import: a complex interplay between virus and host

Z. Debyser, F. Christ, L. Vandekerckhove, 2007, BioEssays : news and reviews in molecular, cellular and developmental biology.

Identification and Characterization of a Functional Nuclear Localization Signal in the HIV-1 Integrase Interactor LEDGF/p75*

A. Engelman, P. Cherepanov, Z. Debyser, 2004, Journal of Biological Chemistry.

Longitudinal follow-up and characterization of a robust rat model for Parkinson's disease based on overexpression of alpha-synuclein with adeno-associated viral vectors

R. D'Hooge, Y. Michotte, G. Bormans, 2015, Neurobiology of Aging.

miR669a and miR669q prevent skeletal muscle differentiation in postnatal cardiac progenitors

B. Zupan, Tomaž Curk, S. Janssens, 2011, The Journal of cell biology.

Y-box-binding protein 1 supports the early and late steps of HIV replication

R. König, C. Weydert, S. Husson, 2018, PloS one.

RNAi-based treatment of HIV/AIDS: Current status and perspectives

R. Gijsbers, Z. Debyser, F. Christ, 2006 .

The HIV-1 Integrase Mutant R263A/K264A Is 2-fold Defective for TRN-SR2 Binding and Viral Nuclear Import*

Susana Rocha, R. Gijsbers, Z. Debyser, 2014, The Journal of Biological Chemistry.

Binding and Viral Nuclear R 263 A / K 264 A Is 2-fold Defective for The HIV-1 Integrase Mutant Microbiology :

Susana Rocha, R. Gijsbers, Z. Debyser, 2014 .

Cellular Cofactors of HIV Integration

Z. Debyser, W. Thys, J. D. Rijck, 2011 .

Lentiviral vector-mediated delivery of short hairpin RNA results in persistent knockdown of gene expression in mouse brain.

B. Nuttin, V. Baekelandt, C. Van den Haute, 2003, Human gene therapy.

Optimized lentiviral vector production and purification procedure prevents immune response after transduction of mouse brain

B. Nuttin, V. Baekelandt, Z. Debyser, 2003, Gene Therapy.

LEDGF/p75 Is Essential for Nuclear and Chromosomal Targeting of HIV-1 Integrase in Human Cells*

E. De Clercq, P. Cherepanov, Z. Debyser, 2003, Journal of Biological Chemistry.

HIV Virions as Nanoscopic Test Tubes for Probing Oligomerization of the Integrase Enzyme

C. Weydert, P. Dedecker, J. Hofkens, 2014, ACS nano.

Characterization of lentiviral vector-mediated gene transfer in adult mouse brain.

Zeger Debyser, Bart Nuttin, Veerle Baekelandt, 2002, Human gene therapy.

Towards a Safer, More Randomized Lentiviral Vector Integration Profile Exploring Artificial LEDGF Chimeras

Zeger Debyser, Rik Gijsbers, Jonas Demeulemeester, 2016, PloS one.

LEDGIN-mediated Inhibition of Integrase–LEDGF/p75 Interaction Reduces Reactivation of Residual Latent HIV

C. Weydert, E. Verdin, A. Cereseto, 2016, EBioMedicine.

LEDGF/p75-Independent HIV-1 Replication Demonstrates a Role for HRP-2 and Remains Sensitive to Inhibition by LEDGINs

F. Bushman, R. Gijsbers, Z. Debyser, 2012, PLoS pathogens.

Noninvasive monitoring of long-term lentiviral vector-mediated gene expression in rodent brain with bioluminescence imaging.

L. Mortelmans, G. Bormans, V. Baekelandt, 2006, Molecular therapy : the journal of the American Society of Gene Therapy.

Phenotyping of Rare CFTR Mutations Reveals Distinct Trafficking and Functional Defects

A. Ramalho, R. Farré, M. Ensinck, 2020, Cells.

Resistance to Inhibitors of HIV‐1 Integrase

R. Clayton, A. Voet, Z. Debyser, 2011 .

Multiple mutations in human immunodeficiency virus-1 integrase confer resistance to the clinical trial drug S-1360

E. De Clercq, C. Pannecouque, M. de Maeyer, 2004, AIDS.

Development of Resistance against Diketo Derivatives of Human Immunodeficiency Virus Type 1 by Progressive Accumulation of Integrase Mutations

E. De Clercq, C. Pannecouque, M. de Maeyer, 2003, Journal of Virology.

Targeting Virus-host Interactions of HIV Replication.

C. Weydert, Z. Debyser, F. Christ, 2015, Current topics in medicinal chemistry.

Kinetics of inhibition of endogenous human immunodeficiency virus type 1 reverse transcription by 2',3'-dideoxynucleoside 5'-triphosphate, tetrahydroimidazo-[4,5,1-jk][1,4]-benzodiazepin-2(1H)-thion e, and 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine derivatives.

E. De Clercq, R. Pauwels, A. Vandamme, 1992, The Journal of biological chemistry.

Protein-protein and protein-chromatin interactions of LEDGF/p75 as novel drug targets.

Z. Debyser, J. Blokken, F. Christ, 2017, Drug discovery today. Technologies.

Design of cell-permeable stapled peptides as HIV-1 integrase inhibitors.

N. Neamati, Z. Debyser, Stéphanie De Houwer, 2013, Journal of medicinal chemistry.

Retroviral integration: Site matters

Zeger Debyser, Rik Gijsbers, Jonas Demeulemeester, 2015, BioEssays : news and reviews in molecular, cellular and developmental biology.

Impact of the Central Polypurine Tract on the Kinetics of Human Immunodeficiency Virus Type 1 Vector Transduction

E. De Clercq, Z. Debyser, B. Van Maele, 2003, Journal of Virology.

Local origin and activity-dependent generation of nestin-expressing protoplasmic astrocytes in CA1

V. Baekelandt, H. Kettenmann, G. Kempermann, 2007, Brain Structure and Function.

Establishment of latent HIV-1 reservoirs: what do we really know?

Z. Debyser, Jef Vanhamel, Anne Bruggemans, 2019, Journal of virus eradication.

LEDGINs, non-catalytic site inhibitors of HIV-1 integrase: a patent review (2006 – 2014)

A. Marchand, M. de Maeyer, Z. Debyser, 2014, Expert opinion on therapeutic patents.

HIV-1 integration as a target for antiretroviral therapy: a review.

E. De Clercq, Z. Debyser, W. Pluymers, 2001, Current drug targets. Infectious disorders.

Dual role of the chromatin-binding factor PHF13 in the pre- and post-integration phases of HIV-1 replication

M. Schindler, Z. Debyser, S. Bolduan, 2017, Open Biology.

CRISPR/Cas9-Induced Mutagenesis Corroborates the Role of Transportin-SR2 in HIV-1 Nuclear Import

R. Gijsbers, Z. Debyser, J. Blokken, 2021, Microbiology spectrum.

LEDGF/p75 and transportin-SR2 are cellular cofactors of HIV integrase and novel targets for antiviral therapy

A. Voet, Z. Debyser, F. Christ, 2009 .

In search of small molecules blocking interactions between HIV proteins and intracellular cofactors.

Z. Debyser, F. Christ, K. Busschots, 2009, Molecular bioSystems.

Towards a Functional Cure of HIV-1: Insight Into the Chromatin Landscape of the Provirus

Z. Debyser, F. Christ, Anne Bruggemans, 2021, Frontiers in Microbiology.

LEDGINs inhibit late stage HIV-1 replication by modulating integrase multimerization in the virions

C. Weydert, N. Bannert, J. Hofkens, 2013, Retrovirology.

Fetal surgery is a clinical reality.

Zeger Debyser, Joris Vermeesch, Gunnar Naulaers, 2010, Seminars in fetal & neonatal medicine.

Allele specific repair of splicing mutations in cystic fibrosis through AsCas12a genome editing

Zeger Debyser, Marianne S Carlon, Anabela S Ramalho, 2019, Nature Communications.

rAAV-CFTRΔR Rescues the Cystic Fibrosis Phenotype in Human Intestinal Organoids and Cystic Fibrosis Mice.

V. Baekelandt, M. Ferrante, A. Ramalho, 2016, American journal of respiratory and critical care medicine.

LEDGINs, Inhibitors of the Interaction Between HIV-1 Integrase and LEDGF/p75, Are Potent Antivirals with a Potential to Cure HIV Infection.

Z. Debyser, F. Christ, S. van Belle, 2021, Advances in experimental medicine and biology.

Dynamic Oligomerization of Integrase Orchestrates HIV Nuclear Entry

J. Hofkens, Jelle Hendrix, Susana Rocha, 2016, Scientific Reports.

The LEDGF/p75 integrase interaction, a novel target for anti-HIV therapy.

Z. Debyser, F. Christ, 2013, Virology.

In vitro DNA tethering of HIV-1 integrase by the transcriptional coactivator LEDGF/p75.

Jelle Hendrix, Z. Debyser, F. Christ, 2011, Journal of molecular biology.

Optimization of Multimodal Imaging of Mesenchymal Stem Cells Using the Human Sodium Iodide Symporter for PET and Cerenkov Luminescence Imaging

C. Casteels, K. Van Laere, C. Verfaillie, 2014, PloS one.

Structure of transportin SR2, a karyopherin involved in human disease, in complex with Ran.

Z. Debyser, V. G. Tsirkone, F. Christ, 2014, Acta crystallographica. Section F, Structural biology communications.

Comparative analysis of adeno-associated viral vector serotypes 1, 2, 5, 7, and 8 in mouse brain.

Zeger Debyser, Luc Mortelmans, Veerle Baekelandt, 2007, Human gene therapy.

Alteration of Cardiac Progenitor Cell Potency in GRMD Dogs

I. Barthélémy, S. Blot, M. Sampaolesi, 2012, Cell transplantation.

A ubiquitous disordered protein interaction module orchestrates transcription elongation

Eric A. Smith, K. Adelman, V. Veverka, 2021, Science.

Resistance of human immunodeficiency virus type 1 reverse transcriptase to TIBO derivatives induced by site-directed mutagenesis.

E. De Clercq, R. Pauwels, A. Vandamme, 1992, Virology.

Association of polymorphisms in the LEDGF/p75 gene (PSIP1) with susceptibility to HIV-1 infection and disease progression

T. Ndung’u, C. Winkler, P. An, 2011, AIDS.

Rapid, simple, and versatile manufacturing of recombinant adeno-associated viral vectors at scale.

M. R. Delgado Alvira, M. Lock, James M. Wilson, 2010, Human gene therapy.

Synthesis and evaluation of 18F- and 11C-labeled phenyl-galactopyranosides as potential probes for in vivo visualization of LacZ gene expression using positron emission tomography.

L. Mortelmans, G. Bormans, T. D. de Groot, 2008, Bioconjugate chemistry.

GS-9822, a Preclinical LEDGIN Candidate, Displays a Block-and-Lock Phenotype in Cell Culture

Z. Debyser, F. Christ, Ruby Z Cai, 2021, Antimicrobial Agents and Chemotherapy.

Design of a novel cyclotide-based CXCR4 antagonist with anti-human immunodeficiency virus (HIV)-1 activity.

N. Neamati, Z. Debyser, F. Christ, 2012, Journal of medicinal chemistry.

Role of Transportin-SR2 in HIV-1 Nuclear Import

Z. Debyser, F. Christ, Iván Nombela, 2021, Viruses.

LEDGF hybrids efficiently retarget lentiviral integration into heterochromatin.

Zeger Debyser, Rik Gijsbers, Frederic D Bushman, 2010, Molecular therapy : the journal of the American Society of Gene Therapy.

In vivo bioluminescence imaging in an experimental mouse model for dendritic cell based immunotherapy against malignant glioma

V. Baekelandt, J. Ceuppens, S. Gool, 2008, Journal of Neuro-Oncology.

Validation of host factors of HIV integration as novel drug targets for anti-HIV therapy

Z. Debyser, B. Desimmie, F. Christ, 2014 .

Role of the PWWP Domain of Lens Epithelium-derived Growth Factor (LEDGF)/p75 Cofactor in Lentiviral Integration Targeting*

F. Bushman, Nirav Malani, R. Gijsbers, 2011, The Journal of Biological Chemistry.

Interplay between HIV Entry and Transportin-SR2 Dependency

R. Gijsbers, Z. Debyser, Stéphanie De Houwer, 2011, Retrovirology.

Single-Cell Imaging of HIV-1 Provirus (SCIP)

A. Cereseto, D. Arosio, R. Gijsbers, 2013, Proceedings of the National Academy of Sciences.

The remarkable conformational plasticity of alpha-synuclein: blessing or curse?

Zeger Debyser, Veerle Baekelandt, V. Baekelandt, 2013, Trends in molecular medicine.

Novel CFTR modulator combinations maximise rescue of G85E and N1303K in rectal organoids

A. Ramalho, L. Dupont, M. Ensinck, 2022, ERJ Open Research.

Noninvasive Bioluminescence Imaging of α-Synuclein Oligomerization in Mouse Brain Using Split Firefly Luciferase Reporters

V. Baekelandt, C. Van den Haute, R. Gijsbers, 2014, The Journal of Neuroscience.

Cellular co-factors of HIV-1 integration.

Z. Debyser, F. Christ, K. Busschots, 2006, Trends in biochemical sciences.

The mutation of Transportin 3 gene that causes limb girdle muscular dystrophy 1F induces protection against HIV-1 infection

Susana Rocha, Z. Debyser, F. De Wit, 2019, PLoS pathogens.

Identification of Residues in the C-terminal Domain of HIV-1 Integrase That Mediate Binding to the Transportin-SR2 Protein*

Z. Debyser, Stéphanie De Houwer, F. Christ, 2012, The Journal of Biological Chemistry.

A novel translational model for fetoscopic intratracheal delivery of nanoparticles in piglets

J. Deprest, D. Vidovic, M. Carlon, 2016, Prenatal diagnosis.

Immunohistochemical detection of transgene expression in the brain using small epitope tags

V. Baekelandt, C. Van den Haute, R. Gijsbers, 2010, BMC biotechnology.

An integrated multi-electrode-optrode array for in vitro optogenetics

Robert Puers, Georges Gielen, Zeger Debyser, 2016, Scientific Reports.

Inhibition of FK506 Binding Proteins Reduces α-Synuclein Aggregation and Parkinson's Disease-Like Pathology

V. Baekelandt, S. Munck, H. Pottel, 2010, The Journal of Neuroscience.

Structure, mechanics, and binding mode heterogeneity of LEDGF/p75-DNA nucleoprotein complexes revealed by scanning force microscopy.

J. Lipfert, Z. Debyser, W. Vanderlinden, 2014, Nanoscale.

Chicoric acid analogues as HIV-1 integrase inhibitors.

K. Kohn, Y. Pommier, E. De Clercq, 1999, Journal of medicinal chemistry.

Establishment of an in vitro assay system mimicking human immunodeficiency virus type 1-induced neural cell death and evaluation of inhibitors thereof.

E. De Clercq, M. Baba, Z. Debyser, 2003, Journal of virological methods.

DNA-Dependent Protein Kinase Is Not Required for Efficient Lentivirus Integration

B. de Strooper, E. De Clercq, B. Nuttin, 2000, Journal of Virology.

Unlike its Paralog LEDGF/p75, HRP-2 Is Dispensable for MLL-R Leukemogenesis but Important for Leukemic Cell Survival

P. Van Vlierberghe, V. Veverka, A. Canella, 2021, Cells.

Molecular Mechanism of LEDGF/p75 Dimerization.

J. Brynda, V. Veverka, K. Cermakova, 2020, Structure.

Targeted editing of the PSIP1 gene encoding LEDGF/p75 protects cells against HIV infection

R. Gijsbers, Z. Debyser, Y. Lampi, 2019, Scientific Reports.

LEDGF/p75 is dispensable for hematopoiesis but essential for MLL-rearranged leukemogenesis.

A. Engelman, P. Van Vlierberghe, Z. Debyser, 2018, Blood.

Multiple cellular proteins interact with LEDGF/p75 through a conserved unstructured consensus motif

V. Veverka, K. Cermakova, K. Procházková, 2015, Nature Communications.

HIV-1 IN/Pol recruits LEDGF/p75 into viral particles

C. Weydert, I. Paron, N. Bannert, 2015, Retrovirology.

Role of LEDGF/p75 in cell biology and disease pathogenesis

Z. Debyser, R. Schrijvers, 2015 .

Identification of small peptides inhibiting the integrase‐LEDGF/p75 interaction through targeting the cellular co‐factor

Kam Y. J. Zhang, A. Voet, M. de Maeyer, 2013, Journal of peptide science : an official publication of the European Peptide Society.

Transient Expression of an LEDGF/p75 Chimera Retargets Lentivector Integration and Functionally Rescues in a Model for X-CGD

F. Bushman, R. Gijsbers, Z. Debyser, 2013, Molecular therapy. Nucleic acids.

Pathway specific gene expression profiling reveals oxidative stress genes potentially regulated by transcription co‐activator LEDGF/p75 in prostate cancer cells

R. Gijsbers, Z. Debyser, C. Casiano, 2012, The Prostate.

De novo design of small molecule inhibitors targeting the LEDGF/p75-HIV integrase interaction

A. Voet, E. V. D. Eycken, Z. Debyser, 2012 .

TheStressOncoproteinLEDGF/p75InteractswiththeMethyl CpG Binding Protein MeCP2 and Influences Its

Sandy S. Tungteakkhun, Z. Debyser, F. Christ, 2012 .

The transcriptional co-activator LEDGF/p75 displays a dynamic scan-and-lock mechanism for chromatin tethering

J. Hofkens, J. Hotta, A. Voet, 2010, Nucleic acids research.

Neuropathology and Neurodegeneration in Rodent Brain Induced by Lentiviral Vectormediated Overexpression of α‐Synuclein

B. Strooper, B. Nuttin, V. Baekelandt, 2003, Brain pathology.

FK506 binding protein 12 differentially accelerates fibril formation of wild type alpha‐synuclein and its clinical mutants A30P or A53T

Zeger Debyser, Veerle Baekelandt, Yves Engelborghs, 2008, Journal of neurochemistry.

Elvitegravir: a once daily alternative to raltegravir.

Z. Debyser, B. Desimmie, R. Schrijvers, 2012, The Lancet. Infectious diseases.

Discovery of N-aryl-naphthylamines as in vitro inhibitors of the interaction between HIV integrase and the cofactor LEDGF/p75.

E. Novellino, R. Di Santo, R. Costi, 2015, European journal of medicinal chemistry.

Viral entry as the primary target for the anti-HIV activity of chicoric acid and its tetra-acetyl esters.

Y. Pommier, E. De Clercq, C. Pannecouque, 2000, Molecular pharmacology.

Comparative evaluation of three ELISA techniques and an indirect immunofluorescence assay for the serological diagnosis of Epstein-Barr virus infection.

Z. Debyser, J. Desmyter, P. Goubau, 1997, Clinical and diagnostic virology.

Differential inhibitory effects of TIBO derivatives on different strains of simian immunodeficiency virus.

E. De Clercq, R. Pauwels, Z. Debyser, 1992, The Journal of general virology.

Transient and Stable Knockdown of the Integrase Cofactor LEDGF/p75 Reveals Its Role in the Replication Cycle of Human Immunodeficiency Virus

C. Van den Haute, R. Gijsbers, Z. Debyser, 2006, Journal of Virology.

A PET Brain Reporter Gene System Based on Type 2 Cannabinoid Receptors

G. Bormans, V. Baekelandt, K. Van Laere, 2011, The Journal of Nuclear Medicine.

Naturally occurring singleton residues in AAV capsid impact vector performance and illustrate structural constraints

James M. Wilson, M. Agbandje-McKenna, Ru Xiao, 2009, Gene Therapy.

Serotype-dependent transduction efficiencies of recombinant adeno-associated viral vectors in monkey neocortex

Zeger Debyser, Wim Vanduffel, Marie-Eve Laramée, 2015, Neurophotonics.

Imaging the Replication of Single Viruses: Lessons Learned from HIV and Future Challenges To Overcome.

J. Hofkens, Jelle Hendrix, Susana Rocha, 2020, ACS nano.

Five-drug antiretroviral therapy for primary HIV infection?

Z. Debyser, R. Schrijvers, 2015, The Lancet. Infectious diseases.

Comparative Analysis of Different Peptidyl-Prolyl Isomerases Reveals FK506-binding Protein 12 as the Most Potent Enhancer of α-Synuclein Aggregation*

L. Buée, V. Baekelandt, H. Pottel, 2011, The Journal of Biological Chemistry.

Longitudinal follow-up and characterization of a robust rat model for Parkinson’s disease based on overexpression of alpha-synuclein with adeno-associated viral vectors. Authors:

Gijsbers, R. D'Hooge, Y. Michotte, 2015 .

Nitrogen-containing polyhydroxylated aromatics as HIV-1 integrase inhibitors: synthesis, structure-activity relationship analysis, and biological activity

N. Neamati, Z. Debyser, F. Christ, 2012, Journal of enzyme inhibition and medicinal chemistry.

The total synthesis of fukiic acid, an HIV-1 integrase inhibitor.

F. Bailly, J. Mouscadet, Z. Debyser, 2008, European journal of medicinal chemistry.

Kuwanon‐L as a New Allosteric HIV‐1 Integrase Inhibitor: Molecular Modeling and Biological Evaluation

C. Tintori, M. Botta, Z. Debyser, 2015, Chembiochem : a European journal of chemical biology.

Rational design of LEDGINs as first allosteric integrase inhibitors for the treatment of HIV infection.

Z. Debyser, B. Desimmie, F. Christ, 2013, Drug discovery today. Technologies.

Simple criterion for selection of flavonoid compounds with anti-HIV activity.

J. Mouscadet, N. Veljkovic, S. Glišić, 2007, Bioorganic & medicinal chemistry letters.

Highly efficient multicistronic lentiviral vectors with peptide 2A sequences.

G. Bormans, V. Baekelandt, C. Deroose, 2009, Human gene therapy.

Microwave‐Assisted Silver(I)‐Mediated Selective O‐Alkylation of Aromatic Imidate Systems.

E. V. D. Eycken, Z. Debyser, Claudia Cavalluzzo, 2010 .

Microwave-Assisted Silver(I)-Mediated Selective O-Alkylation of Aromatic Imidate Systems

E. V. D. Eycken, Z. Debyser, Claudia Cavalluzzo, 2009 .

The α Crystallin Domain of Small Heat Shock Protein b8 (Hspb8) Acts as Survival and Differentiation Factor in Adult Hippocampal Neurogenesis

V. Baekelandt, K. Fabel, G. Kempermann, 2013, The Journal of Neuroscience.

Concise Review: Therapeutic Strategies for Parkinson Disease Based on the Modulation of Adult Neurogenesis

V. Baekelandt, Z. Debyser, M. Geraerts, 2007, Stem cells.

Noninvasive and Quantitative Monitoring of Adult Neuronal Stem Cell Migration in Mouse Brain Using Bioluminescence Imaging

Zeger Debyser, Johan Nuyts, Luc Mortelmans, 2008, Stem cells.

Lentiviral vectors mediate efficient and stable gene transfer in adult neural stem cells in vivo.

Zeger Debyser, Veerle Baekelandt, J. García-Verdugo, 2006, Human gene therapy.

Evaluation of the specificity and sensitivity of ferritin as an MRI reporter gene in the mouse brain using lentiviral and adeno-associated viral vectors

U Himmelreich, F Maes, R Vreys, 2011, Gene Therapy.

Differential effects of progenitor cell populations on left ventricular remodeling and myocardial neovascularization after myocardial infarction.

F. Van de Werf, F. Maes, J. Bogaert, 2010, Journal of the American College of Cardiology.

Viral vectors expressing a single microRNA-based short-hairpin RNA result in potent gene silencing in vitro and in vivo.

V. Baekelandt, C. Van den Haute, R. Gijsbers, 2014, Journal of biotechnology.

Photoconversion of Far‐Red Organic Dyes: Implications for Multicolor Super‐Resolution Imaging

J. Hofkens, E. Fron, Susana Rocha, 2018 .

DNA-induced Polymerization of HIV-1 Integrase Analyzed with Fluorescence Fluctuation Spectroscopy*

Jo Vercammen, Zeger Debyser, Yves Engelborghs, 2002, The Journal of Biological Chemistry.

HIV-1 IN/Pol recruits LEDGF/p75 into viral particles

C. Weydert, I. Paron, N. Bannert, 2015, Retrovirology.

Virus Evolution Reveals an Exclusive Role for LEDGF/p75 in Chromosomal Tethering of HIV

Myriam Witvrouw, Zeger Debyser, Linos Vandekerckhove, 2007, PLoS pathogens.

Article Transportin-SR2 Imports HIV into the Nucleus

J. Rain, R. Benarous, A. Cereseto, 2008 .

Fetal gene transfer with lentiviral vectors: long-term in vivo follow-up evaluation in a rat model.

L. Mortelmans, G. Bormans, J. Deprest, 2007, American journal of obstetrics and gynecology.

New Class of HIV Integrase Inhibitors that Block Viral Replication in Cell Culture

Myriam Witvrouw, Zeger Debyser, Erik De Clercq, 2002, Current Biology.

Preclinical Evaluation of 1H-Benzylindole Derivatives as Novel Human Immunodeﬁciency Virus Integrase Strand Transfer Inhibitors (cid:1)

L. Vrang, Z. Debyser, F. Christ, 2008 .

Correction to: HIV-1 IN/Pol recruits LEDGF/p75 into viral particles

C. Weydert, I. Paron, N. Bannert, 2020, Retrovirology.

HRP-2 determines HIV-1 integration site selection in LEDGF/p75 depleted cells

F. Bushman, Nirav Malani, R. Gijsbers, 2012, Retrovirology.

Capsid-Labelled HIV To Investigate the Role of Capsid during Nuclear Import and Integration

J. Hofkens, Jelle Hendrix, Susana Rocha, 2020, Journal of Virology.

Discovery of small molecule HIV-1 integrase dimerization inhibitors.

Cristina Tintori, Silvio Massa, Zeger Debyser, 2012, Bioorganic & medicinal chemistry letters.

A p-[18F]fluoroethoxyphenyl bicyclic nucleoside analogue as a potential positron emission tomography imaging agent for varicella-zoster virus thymidine kinase gene expression.

L. Mortelmans, G. Bormans, C. Deroose, 2007, Journal of Medicinal Chemistry.

Synthesis and biological evaluation of an 123I-labeled bicyclic nucleoside analogue (BCNA) as potential SPECT tracer for VZV-tk reporter gene imaging.

Zeger Debyser, Jan Balzarini, Luc Mortelmans, 2007, Bioorganic & Medicinal Chemistry Letters.

Morphologic and functional changes in the unilateral 6-hydroxydopamine lesion rat model for Parkinson’s disease discerned with μSPECT and quantitative MRI

Zeger Debyser, Jan Sijbers, Marleen Verhoye, 2010, Magnetic Resonance Materials in Physics, Biology and Medicine.

New 2-arylnaphthalenediols and triol inhibitors of HIV-1 integrase--discovery of a new polyhydroxylated antiviral agent.

F. Bailly, H. Vezin, J. Mouscadet, 2010, Bioorganic & medicinal chemistry.

Impact of LEDGIN treatment during virus production on residual HIV-1 transcription

R. Gijsbers, Z. Debyser, Irena Zurnić, 2019, Retrovirology.

HIV-1 integrase strand-transfer inhibitors: design, synthesis and molecular modeling investigation.

Z. Debyser, F. Christ, S. Ferro, 2011, European journal of medicinal chemistry.

Synthesis and Anti-HIV Profile of a Novel Tetrahydroindazolylbenzamide Derivative Obtained by Oxazolone Chemistry

A. Scala, Z. Debyser, F. Christ, 2018, ACS medicinal chemistry letters.

Design of reverse transcriptase–specific nucleosides to visualize early steps of HIV-1 replication by click labeling

A. Venkatesham, Z. Debyser, A. Van Aerschot, 2019, The Journal of Biological Chemistry.

MX2 restricts HIV-1 and herpes simplex virus-1 by forming cytoplasmic biomolecular condensates that mimic nuclear pore complexes

S. Eyckerman, E. Parthoens, Z. Debyser, 2023, bioRxiv.

Particle-based phasor-FLIM-FRET resolves protein-protein interactions inside single viral particles

J. Hofkens, Jelle Hendrix, Z. Debyser, 2023, bioRxiv.

Proceedings of the Frontiers of Retrovirology Conference 2016

Sebastian A. Wagner, R. König, D. Elleder, 2016, Retrovirology.

Inhibitors of the integrase–transportin-SR2 interaction block HIV nuclear import

A. Marchand, Z. Debyser, Lieve Dirix, 2018, Retrovirology.

Interaction of Transportin-SR2 with Ras-related Nuclear Protein (Ran) GTPase*

Z. Debyser, V. G. Tsirkone, Stéphanie De Houwer, 2013, The Journal of Biological Chemistry.

Role of Transportin-SR2 (Transportin-3, TRN-SR2, TNPO3) in HIV replication

Z. Debyser, F. Christ, 2015 .

Interaction of TRN-SR 2 with Ran 1 Interaction of Transportin-SR 2 with Ras-related nuclear protein ( Ran ) GTPase *

Z. Debyser, V. G. Tsirkone, F. Christ, 2013 .

LEDGINs reveal a role for LEDGF/p75 in late stage HIV replication

C. Weydert, N. Bannert, Jelle Hendrix, 2013 .

Full-length genomic sequence of an HIV type 1 subtype G from Kinshasa.

F. McCutchan, K. Van Laethem, A. Vandamme, 1999, AIDS research and human retroviruses.

2-hydroxyisoquinoline-1,3(2H,4H)-diones (HIDs) as human immunodeficiency virus type 1 integrase inhibitors: Influence of the alkylcarboxamide substitution of position 4.

F. Bailly, Z. Debyser, M. Andreola, 2016, European journal of medicinal chemistry.

Evaluation of the activity of HIV-1 integrase over-expressed in eukaryotic cells.

Z. Debyser, W. Pluymers, B. Van Maele, 2005, Biochemical and biophysical research communications.

Non-invasive imaging of neuropathology in a rat model of alpha-synuclein overexpression.

Zeger Debyser, Johan Nuyts, Koen Van Laere, 2007, Neurobiology of aging.

Interaction of the HIV-1 intasome with Transportin 3 ( TNPO 3 or TRN-SR 2 )

G. Duyne, M. Foster, Kushol Gupta, 2012 .

The aggregation of alpha‐synuclein is stimulated by FK506 binding proteins as shown by fluorescence correlation spectroscopy

Zeger Debyser, Veerle Baekelandt, Yves Engelborghs, 2006, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Mutations in Human Immunodeﬁciency Virus Type 1 Integrase Confer Resistance to the Naphthyridine L-870,810 and Cross-Resistance to the Clinical Trial Drug GS-9137 (cid:1)

A. Voet, Z. Debyser, M. Witvrouw, 2008 .

Targeted editing of the PSIP1 gene encoding LEDGF/p75 protects cells against HIV infection

R. Gijsbers, Z. Debyser, Y. Lampi, 2019, Scientific Reports.

Inhibitors of the integrase–transportin-SR2 interaction block HIV nuclear import

A. Marchand, Z. Debyser, Lieve Dirix, 2018, Retrovirology.

Characterization of rare lens epithelium-derived growth factor/p75 genetic variants identified in HIV-1 long-term nonprogressors

R. Gijsbers, Z. Debyser, F. Christ, 2013, AIDS (London).

CRISPR/Cas9-Induced Mutagenesis Corroborates the Role of Transportin-SR2 in HIV-1 Nuclear Import

K. Steel, A. Forge, N. Ingham, 2014, Stem Cell Research & Therapy.

Allosteric inhibition of human immunodeficiency virus type 1 reverse transcriptase by tetrahydroimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-one and -thione compounds.

E. De Clercq, R. Pauwels, Z. Debyser, 1992, Molecular Pharmacology.