M. Uhlik

发表

Rac–MEKK3–MKK3 scaffolding for p38 MAPK activation during hyperosmotic shock

M. Dell'Acqua, Eric A. Horne, B. Cuevas, 2003, Nature Cell Biology.

Identification of LY2510924, a Novel Cyclic Peptide CXCR4 Antagonist That Exhibits Antitumor Activities in Solid Tumor and Breast Cancer Metastatic Models

Kelly M Credille, Donald Paul, Yu-Hua Hui, 2014, Molecular Cancer Therapeutics.

Modern phenotypic drug discovery is a viable, neoclassic pharma strategy.

D. Sall, Jonathan A. Lee, C. Moxham, 2012, Journal of medicinal chemistry.

A Quantitative, Facile, and High-Throughput Image-Based Cell Migration Method Is a Robust Alternative to the Scratch Assay

Jonathan A. Lee, M. Uhlik, W. Gough, 2011, Journal of biomolecular screening.

High-content multiplexed tissue imaging and quantification for cancer drug discovery.

M. Uhlik, J. Stewart, J. Wijsman, 2013, Drug discovery today.

A transforming mutation in the pleckstrin homology domain of AKT1 in cancer

Spyro Mousses, Michael Bittner, Galen Hostetter, 2007, Nature.

Discovery of LY2457546: a multi-targeted anti-angiogenic kinase inhibitor with a novel spectrum of activity and exquisite potency in the acute myelogenous leukemia-Flt-3-internal tandem duplication mutant human tumor xenograft model

D. Clawson, Eileen L. Considine, M. Uhlik, 2012, Investigational New Drugs.

Inhibition of Sphingosine Phosphate Receptor 1 Signaling Enhances the Efficacy of VEGF Receptor Inhibition

D. Alsop, P. Hipskind, Xiaoen Wang, 2019, Molecular Cancer Therapeutics.

An In Vitro Cord Formation Assay Identifies Unique Vascular Phenotypes Associated with Angiogenic Growth Factors

Jonathan A. Lee, R. Foreman, M. Uhlik, 2014, PloS one.

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two

Manish R. Patel, Charles J. Vaske, Joe Y. Chang, 2016, Journal for Immunotherapy of Cancer.

Somatic mutagenesis studies of NF-κB signaling in human T cells: evidence for an essential role of IKKγ in NF-κB activation by T-cell costimulatory signals and HTLV-I Tax protein

E. Harhaj, G. Xiao, Shao-Cong Sun, 2000, Oncogene.

Somatic mutagenesis studies of NF-kappa B signaling in human T cells: evidence for an essential role of IKK gamma in NF-kappa B activation by T-cell costimulatory signals and HTLV-I Tax protein.

E. Harhaj, G. Xiao, S. Sun, 2000, Oncogene.

Retroviral oncoprotein Tax induces processing of NF-kappaB2/p100 in T cells: evidence for the involvement of IKKalpha.

E. Harhaj, G. Xiao, S. Sun, 2001, The EMBO journal.

Recent advances in automated imaging have enabled high-content quantification of tumor phenotypes to aid cancer drug discovery

M. Uhlik, J. Stewart, J. Wijsman, 2012 .

Scratch Assay A Quantitative, Facile, and High-Throughput Image-Based Cell Migration Method Is a Robust Alternative to the

Lei Yan, Keren I. Hulkower, Wendy H. Gough, 2013 .

Development and characterization of a high-throughput in vitro cord formation model insensitive to VEGF inhibition

D. McEwen, G. Evans, M. Uhlik, 2013, Journal of Hematology & Oncology.

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): late breaking abstracts

Amanda R. Campbell, F. Lund-Johansen, Yair Benita, 2016 .

Inhibition of CXCR4 by LY2624587, a Fully Humanized Anti-CXCR4 Antibody Induces Apoptosis of Hematologic Malignancies

M. Uhlik, Sheng-Bin Peng, Xiaoyi Zhang, 2016, PloS one.

PB1 Domain-Dependent Signaling Complex Is Required for Extracellular Signal-Regulated Kinase 5 Activation

K. Hahn, G. Johnson, M. Uhlik, 2006, Molecular and Cellular Biology.

CCM1 and CCM2 protein interactions in cell signaling: implications for cerebral cavernous malformations pathogenesis.

D. Marchuk, B. Ancrile, G. Johnson, 2005, Human molecular genetics.

NF-κB-inducing Kinase and IκB Kinase Participate in Human T-cell Leukemia Virus I Tax-mediated NF-κB Activation*

E. Zandi, M. Karin, E. Harhaj, 1998, The Journal of Biological Chemistry.

MEKK1 regulates the AP-1 dimer repertoire via control of JunB transcription and Fra-2 protein stability

B. Cuevas, T. Garrington, G. Johnson, 2005, Oncogene.

Structural and evolutionary division of phosphotyrosine binding (PTB) domains.

Sompop Bencharit, D. Siderovski, G. Johnson, 2005, Journal of molecular biology.

Ablation of MEKK4 Kinase Activity Causes Neurulation and Skeletal Patterning Defects in the Mouse Embryo

T. Magnuson, A. Winter-Vann, L. Heasley, 2005, Molecular and Cellular Biology.

Retroviral oncoprotein Tax induces processing of NF‐κB2/p100 in T cells: evidence for the involvement of IKKα

E. Harhaj, G. Xiao, A. Fong, 2001 .

Stromal-Based Signatures for the Classification of Gastric Cancer.

Fiona Ginty, Yousef Al-Kofahi, Christopher J. Sevinsky, 2016, Cancer research.

NF-kappaB-inducing kinase and IkappaB kinase participate in human T-cell leukemia virus I Tax-mediated NF-kappaB activation.

E. Zandi, M. Karin, E. Harhaj, 1998, The Journal of biological chemistry.

Somatic Mutations in CCK2R Alter Receptor Activity that Promote Oncogenic Phenotypes

K. Kinzler, B. Vogelstein, V. Velculescu, 2012, Molecular Cancer Research.

Antagonist antibodies to vascular endothelial growth factor receptor 2 (VEGFR-2) as anti-angiogenic agents.

M. Uhlik, Beverly L. Falcón, B. Pytowski, 2016, Pharmacology & therapeutics.

Imprime PGG Enhances Anti-Tumor Effects of Tumor-Targeting, Anti-Angiogenic, and Immune Checkpoint Inhibitor Antibodies

J. Graff, M. Uhlik, N. Bose, 2022, Frontiers in Oncology.

Low-Dose Metronomic Oral Dosing of a Prodrug of Gemcitabine (LY2334737) Causes Antitumor Effects in the Absence of Inhibition of Systemic Vasculogenesis

R. Kerbel, Y. Shaked, S. Man, 2011, Molecular Cancer Therapeutics.

LY2801653 is an orally bioavailable multi-kinase inhibitor with potent activity against MET, MST1R, and other oncoproteins, and displays anti-tumor activities in mouse xenograft models

J. Graff, R. Walgren, C. Shih, 2012, Investigational New Drugs.

An Endothelial Cell/Mesenchymal Stem Cell Coculture Cord Formation Assay to Model Vascular Biology In Vitro.

M. Uhlik, Beverly L. Falcón, Sudhakar Chintharlapalli, 2018, Methods in molecular biology.

Binding of c-Rel to STAT5 target sequences in HTLV-I-transformed T cells

E. Harhaj, Shao-Cong Sun, M. Uhlik, 1999, Oncogene.

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part one

Charles J. Vaske, Rohan N. Borkar, Brian D. Kelly, 2016, Journal of Immunotherapy for Cancer.

Tasisulam Sodium, an Antitumor Agent That Inhibits Mitotic Progression and Induces Vascular Normalization

G. Evans, M. Uhlik, J. Stewart, 2011, Molecular Cancer Therapeutics.

Wiring diagrams of MAPK regulation by MEKK1, 2, and 3.

B. Cuevas, G. Johnson, M. Uhlik, 2004, Biochemistry and cell biology = Biochimie et biologie cellulaire.

Immune Pharmacodynamic Responses of the Novel Cancer Immunotherapeutic Imprime PGG in Healthy Volunteers

J. Graff, M. Uhlik, Kathryn A. Fraser, 2019, The Journal of Immunology.

Abstract LB-129: Imprime PGG, a soluble yeast β-glucan PAMP, in combination with Pembrolizumab induces infiltration and activation of both innate and adaptive immune cells within tumor sites in melanoma and triple-negative breast cancer (TNBC) patients

J. Graff, M. Uhlik, B. Osterwalder, 2018, Immunology.

Xerna™ TME Panel is a machine learning-based transcriptomic biomarker designed to predict therapeutic response in multiple cancers

Rafael D. Rosengarten, Jeeyun Lee, M. Uhlik, 2023, Frontiers in Oncology.

Abstract 1232: Xerna࣪ TME Panel: A pan-cancer RNA-based investigational assay designed to predict patient responses to angiogenic and immune targeted therapies

Rafael D. Rosengarten, Jeeyun Lee, M. Uhlik, 2022, Cancer Research.

Abstract PD1-02: Response and clinical benefit assessment of the combination of the dectin-1 agonist imprime PGG and anti-PD-1 pembrolizumab in chemotherapy-resistant metastatic triple negative breast cancer (TNBC)

A. Stopeck, V. Borges, J. Graff, 2020 .

A small molecule inhibitor of TGFβ RI kinase potentiates VEGF dependent angiogenesis in vitro

J. Yingling, R. Foreman, M. Uhlik, 2006 .

Multiple Structural Domains within IκBα Are Required for Its Inducible Degradation by both Cytokines and Phosphatase Inhibitors

Shao-Cong Sun, M. Uhlik, S. Maggirwar, 1996 .

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): late breaking abstracts

Amanda R. Campbell, F. Lund-Johansen, Yair Benita, 2016 .

Modern phenotypic drug discovery is a viable, neoclassic pharma strategy.

Jonathan A. Lee, C. Moxham, M. Uhlik, 2012, Journal of medicinal chemistry.

Identification of LY2510924, a Novel Cyclic Peptide CXCR4 Antagonist That Exhibits Antitumor Activities in Solid Tumor and Breast Cancer Metastatic Models

M. Uhlik, Sheng-Bin Peng, Xiaoyi Zhang, 2014, Molecular Cancer Therapeutics.

Kupffer cells prevent pancreatic ductal adenocarcinoma metastasis to the liver in mice

M. Uhlik, N. Bose, G. Beatty, 2023, Nature communications.

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two

Charles J. Vaske, Joe Y. Chang, Scott R. Presnell, 2016, Journal for ImmunoTherapy of Cancer.

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part one

Charles J. Vaske, Rohan N. Borkar, David M. Schauder, 2016, Journal for ImmunoTherapy of Cancer.