P. Cabrales

发表

Prediction of Recovery From Severe Hemorrhagic Shock Using Logistic Regression

Alexander T. Williams, Alfredo Lucas, P. Cabrales, 2019, IEEE Journal of Translational Engineering in Health and Medicine.

Notch-independent RBPJ controls angiogenesis in the adult heart

P. Ruiz-Lozano, K. Peterson, R. Dı́az-Trelles, 2016, Nature Communications.

CX3CL1-Fc treatment prevents atherosclerosis in Ldlr KO mice

A. Fanjul, K. Ley, J. Olefsky, 2018, Molecular metabolism.

Cardiovascular Signaling Malfunction Induced by Stored Blood Transfusion

P. Cabrales, 2012 .

Transfusion restores blood viscosity and reinstates microvascular conditions from hemorrhagic shock independent of oxygen carrying capacity.

P. Cabrales, M. Intaglietta, A. G. Tsai, 2007, Resuscitation.

IS RESUSCITATION FROM HEMORRHAGIC SHOCK LIMITED BY BLOOD OXYGEN-CARRYING CAPACITY OR BLOOD VISCOSITY?

P. Cabrales, M. Intaglietta, A. G. Tsai, 2007, Shock.

Plasma viscosity regulates systemic and microvascular perfusion during acute extreme anemic conditions.

P. Cabrales, A. G. Tsai, A. Tsai, 2006, American journal of physiology. Heart and circulatory physiology.

Increased hematocrit and reduced blood pressure following control of glycemia in diabetes.

P. Cabrales, M. Intaglietta, B. S. Salazar Vázquez, 2008, Clinical hemorheology and microcirculation.

Time-dependant oxygen partial pressure in capillaries and tissue in the hamster window chamber model.

P. Cabrales, M. Intaglietta, 2007, Antioxidants & redox signaling.

Oxygen distribution and respiration by the microcirculation.

P. Cabrales, M. Intaglietta, A. G. Tsai, 2004, Antioxidants & redox signaling.

Impact of hemoglobin nitrite to nitric oxide reductase on blood transfusion for resuscitation from hemorrhagic shock

P. Cabrales, B. Oronsky, J. Scicinski, 2015, Asian journal of transfusion science.

Intravital Microscopy of the Mouse Brain Microcirculation using a Closed Cranial Window

P. Cabrales, L. Carvalho, 2010, Journal of visualized experiments : JoVE.

Immunopathology and Infectious Diseases Murine Cerebral Malaria Is Associated with a Vasospasm-Like Microcirculatory Dysfunction , and Survival upon Rescue Treatment Is Markedly Increased by Nimodipine

J. Frangos, P. Cabrales, L. Carvalho, 2010 .

Exogenous nitric oxide decreases brain vascular inflammation, leakage and venular resistance during Plasmodium berghei ANKA infection in mice

J. Frangos, P. Cabrales, L. Carvalho, 2011, Journal of Neuroinflammation.

Exogenous intravascular nitric oxide enhances ventricular function after hemodilution with plasma expander.

P. Cabrales, S. Chatpun, 2012, Life sciences.

Cardiac mechanoenergetic cost of elevated plasma viscosity after moderate hemodilution.

P. Cabrales, S. Chatpun, 2010, Biorheology.

The Role of Blood and Plasma Viscosity in Restoring Oxygen Delivery Capacity

P. Cabrales, M. Intaglietta, A. G. Tsai, 2013 .

Microvascular and systemic effects following top load administration of saturated carbon monoxide-saline solution*

M. Suematsu, P. Cabrales, M. Intaglietta, 2007, Critical care medicine.

Loss of Function in Heparan Sulfate Elongation Genes EXT1 and EXT 2 Results in Improved Nitric Oxide Bioavailability and Endothelial Function

J. Kastelein, M. Nieuwdorp, J. Esko, 2014, Journal of the American Heart Association.

Replacing the Transfusion of 1–2 Units of Blood with Plasma Expanders that Increase Oxygen Delivery Capacity: Evidence from Experimental Studies

S. Subramaniam, D. Tartakovsky, E. Kistler, 2014, Journal of functional biomaterials.

Itaconate modulates tricarboxylic acid and redox metabolism to mitigate reperfusion injury

Christian M. Metallo, Ajit S. Divakaruni, C. Metallo, 2019, Molecular metabolism.

Partial Response in an RRx-001-Primed Patient with Refractory Small-Cell Lung Cancer after a Third Introduction of Platinum Doublets

P. Cabrales, T. Reid, B. Oronsky, 2016, Case Reports in Oncology.

Endothelin receptor B, a candidate gene from human studies at high altitude, improves cardiac tolerance to hypoxia in genetically engineered heterozygote mice

V. Bafna, A. McCulloch, R. Ronen, 2015, Proceedings of the National Academy of Sciences.

Nitrite may serve as a combination partner and a biomarker for the anti-cancer activity of RRx-001.

P. Cabrales, B. Oronsky, O. Yalcin, 2019, Biorheology.

Resuscitation from hemorrhagic shock: recovery of oxygen carrying capacity or perfusion? Efficacy of new plasma expanders

P. Cabrales, M. Intaglietta, S. Acharya, 2007 .

Rat red blood cell storage lesions in various additive solutions.

Alexander T. Williams, P. Cabrales, V. Jani, 2017, Clinical hemorheology and microcirculation.

Erythrocyte Aging, Protection via Vesiculation: An Analysis Methodology via Oscillatory Flow

R. Asaro, P. Cabrales, Q. Zhu, 2018, Front. Physiol..

Hemorrhagic shock resuscitation with carbon monoxide saturated blood.

P. Cabrales, M. Intaglietta, A. Tsai, 2007, Resuscitation.

The Beneficial Effects of Increasing Blood Viscosity

P. Cabrales, M. Intaglietta, B. Y. S. Vázquez, 2008 .

Mechanotransduction and the homeostatic significance of maintaining blood viscosity in hypotension, hypertension and haemorrhage

P. Cabrales, M. Intaglietta, J. Martini, 2006, Journal of internal medicine.

Blood viscosity: a factor in tissue survival?

P. Cabrales, M. Intaglietta, A. Tsai, 2005, Critical care medicine.

Alginate plasma expander maintains perfusion and plasma viscosity during extreme hemodilution.

P. Cabrales, M. Intaglietta, A. Tsai, 2005, American journal of physiology. Heart and circulatory physiology.

The Disconnect Between Extracorporeal Circulation and the Microcirculation: A Review

P. Cabrales, Vinay P Jani, Krianthan Govender, 2022, ASAIO journal.

Nitric Oxide Synthase Dysfunction Contributes to Impaired Cerebroarteriolar Reactivity in Experimental Cerebral Malaria

J. Frangos, B. Melchior, P. Ong, 2013, PLoS pathogens.

NEGATIVE PRESSURE INCREASES MICROVASCULAR PERFUSION DURING SEVERE HEMORRHAGIC SHOCK.

Alexander T. Williams, P. Cabrales, Carlos J. Munoz, 2020, Microvascular research.

Effects of erythrocyte flexibility on microvascular perfusion and oxygenation during acute anemia.

P. Cabrales, 2007, American journal of physiology. Heart and circulatory physiology.

Exogenous nitric oxide induces protection during hemorrhagic shock.

P. Cabrales, M. Intaglietta, A. Tsai, 2009, Resuscitation.

Perfluorocarbons as gas transporters for O2, NO, CO and volatile anesthetics

P. Cabrales, M. Intaglietta, A. C. Negrete, 2007 .

Extracorporeal circulation impairs microcirculation perfusion and organ function.

P. Cabrales, Krianthan Govender, 2022, Journal of applied physiology.

Cardiac-specific knockout and pharmacological inhibition of Endothelin receptor type B lead to cardiac resistance to extreme hypoxia

Alexander T. Williams, G. Haddad, Dan Zhou, 2018, Journal of Molecular Medicine.

Modulation of perfusion and oxygenation by red blood cell oxygen affinity during acute anemia.

P. Cabrales, M. Intaglietta, A. Tsai, 2008, American journal of respiratory cell and molecular biology.

Oxygen transport by low and normal oxygen affinity hemoglobin vesicles in extreme hemodilution.

S. Takeoka, E. Tsuchida, P. Cabrales, 2005, American journal of physiology. Heart and circulatory physiology.

Nitric Oxide Synthase Inhibition Attenuates Cardiac Response to Hemodilution with Viscogenic Plasma Expander

P. Cabrales, S. Chatpun, 2014, Korean circulation journal.

Reduction of Oxygen-Carrying Capacity Weakens the Effects of Increased Plasma Viscosity on Cardiac Performance in Anesthetized Hemodilution Model

P. Cabrales, S. Chatpun, 2012 .

Effects of plasma viscosity modulation on cardiac function during moderate hemodilution

P. Cabrales, S. Chatpun, 2010, Asian journal of transfusion science.

Cardiac Performance during Acute Hemmorrhagic Shock in Pentobarbital-Anesthetized Hamsters using Left Ventricular Pressure-Volume Measurement

P. Cabrales, S. Chatpun, 2010, BioMed 2010.

A look inside the mechanistic black box: Are red blood cells the critical effectors of RRx-001 cytotoxicity?

A. Oronsky, P. Cabrales, M. Fens, 2016, Medical Oncology.

Platelet inhibitory effects of the Phase 3 anticancer and normal tissue cytoprotective agent, RRx‐001

P. Cabrales, B. Oronsky, Neil Oronsky, 2018, Journal of cellular and molecular medicine.

inhibitory of the Phase anticancer and normal tissue cytoprotective agent, RRx-001.

P. Cabrales, B. Oronsky, Neil Oronsky, 2018 .

Conversion of Platinum-Etoposide-Resistant to Sensitive SCLC after Treatment with the Epi-Immunotherapeutic RRx-001: A Case Report

R. Day, A. Oronsky, P. Cabrales, 2016, Oncology Research and Treatment.

Increased tissue PO2 and decreased O2 delivery and consumption after 80% exchange transfusion with polymerized hemoglobin.

P. Cabrales, M. Intaglietta, A. Tsai, 2004, American journal of physiology. Heart and circulatory physiology.

Microvascular and capillary perfusion following glycocalyx degradation.

P. Cabrales, M. Intaglietta, A. Tsai, 2007, Journal of applied physiology.

Prospects for Human Erythrocyte Skeleton-Bilayer Dissociation during Splenic Flow.

R. Asaro, P. Cabrales, Sara Salehyar, 2017, Biophysical journal.

Title Prospects for Human Erythrocyte Skeleton-Bilayer Dissociation during Splenic

R. Asaro, P. Cabrales, Sara Salehyar, 2022 .

Radio: Epigenetic Inhibitors as Potential Radiopriming Agents.

A. Oronsky, P. Cabrales, T. Reid, 2016 .

RRx-001 Acts as a Dual Small Molecule Checkpoint Inhibitor by Downregulating CD47 on Cancer Cells and SIRP-α on Monocytes/Macrophages

P. Cabrales, 2019, Translational oncology.

Delaying Blood Transfusion in Experimental Acute Anemia with a Perfluorocarbon Emulsion

P. Cabrales, Juan Carlos Briceño, 2011, Anesthesiology.

glycocalyx degradation Microvascular and capillary perfusion following

H. H. Lipowsky, B. Janssen, P. Cabrales, 2015 .

UNIVERSITY OF CALIFORNIA, SAN DIEGO Identification of Mutations in Chronic Lymphocytic Leukemia using ccf-DNA Isolated by Dielectrophoresis A thesis submitted in partial satisfaction of the requirements for the degree Master of Science in Bioengineering

P. Cabrales, Sareh Manouchehri, 2015 .

RRx-001 protects normal tissues but not tumors via Nrf2 induction and Bcl-2 inhibition

P. Cabrales, R. Aggarwal, B. Oronsky, 2019, Journal of Cancer Research and Clinical Oncology.

Chapter 31. Perfluorocarbon Emulsions

P. Cabrales, 2010 .

Terminal lymphatics: the potential "lethal corner" in the distribution of tissue pO2.

P. Cabrales, M. Intaglietta, Nanae Hangai-Hoger, 2007, Lymphatic research and biology.

The vascular wall as a regulator of tissue oxygenation

P. Cabrales, M. Intaglietta, B. Friesenecker, 2006, Current opinion in nephrology and hypertension.

TISSUE OXIDATIVE METABOLISM AFTER EXTREME HEMODILUTION WITH PEG CONJUGATED HEMOGLOBIN

P. Cabrales, 2010, Journal of applied physiology.

Nonlinear cardiovascular regulation consequent to changes in blood viscosity.

P. Cabrales, M. Intaglietta, B. S. Salazar Vázquez, 2011, Clinical hemorheology and microcirculation.

Hematocrit and mean arterial blood pressure in pre- and postmenopause women

U. de Faire, P. Cabrales, M. Intaglietta, 2009, Vascular health and risk management.

Vascular Health and Risk Management Dovepress Open Access to Scientific and Medical Research Open Access Full Text Article Hematocrit and Mean Arterial Blood Pressure in Pre-and Postmenopause Women Ulf De Faire

U. de Faire, P. Cabrales, M. Intaglietta, 2022 .

Oxygen release from low and normal P50 Hb vesicles in transiently occluded arterioles of the hamster window model.

E. Tsuchida, P. Cabrales, M. Intaglietta, 2005, American journal of physiology. Heart and circulatory physiology.

Chapter 7 – Mechanisms of Oxygen Transport in the Microcirculation: Effects of Cell-Free Oxygen Carriers

P. Cabrales, M. Intaglietta, A. Tsai, 2006 .

Role of endothelial nitric oxide in microvascular oxygen delivery and consumption.

J. Frangos, P. Cabrales, M. Intaglietta, 2005, Free radical biology & medicine.

Hemoglobin encapsulated poly(ethylene glycol) surface conjugated vesicles attenuate vasoactivity of cell-free hemoglobin.

A. Palmer, P. Cabrales, Shahid Rameez, 2012, Current drug discovery technologies.

exchange during hypoxia and hyperoxia Nitric oxide regulation of microvascular oxygen

A. Palmer, P. Cabrales, M. Intaglietta, 2015 .

Nitric oxide regulation of microvascular oxygen exchange during hypoxia and hyperoxia.

P. Cabrales, M. Intaglietta, A. Tsai, 2006, Journal of applied physiology.

Increases Erythrocyte Preferential Adhesion to the Vasculature.

R. Asaro, P. Cabrales, B. Oronsky, 2021 .

Effects of Fibrinogen Concentrate After Shock/Resuscitation: A Comparison Between In Vivo Microvascular Clot Formation and Thromboelastometry*

P. Cabrales, M. Intaglietta, D. Fries, 2013, Critical care medicine.

Cerebral tissue oxygenation impairment during experimental cerebral malaria

J. Frangos, P. Ong, P. Cabrales, 2013, Virulence.

S-nitrosoglutathione Prevents Experimental Cerebral Malaria

J. Frangos, P. Cabrales, L. Carvalho, 2012, Journal of Neuroimmune Pharmacology.

New phosphorescence quenching oxygen measurements technique yields unusual tissue and plasma PO2 distributions.

Paul C. Johnson, P. Cabrales, M. Intaglietta, 2007, Journal of applied physiology.

Acute kidney function and morphology following topload administration of recombinant hemoglobin solution

P. Cabrales, M. Intaglietta, Y. Castiglia, 2017, Artificial cells, nanomedicine, and biotechnology.

Quantitative analysis of spatial irregularities in RBCs flows

M. Bucolo, F. Cairone, P. Cabrales, 2018, Chaos, Solitons & Fractals.

Microvascular effects following treatment with polyethylene glycol-albumin in lipopolysaccharide-induced endotoxemia

B. Manjula, P. Cabrales, M. Intaglietta, 2006, Critical care medicine.

Blood viscosity maintains microvascular conditions during normovolemic anemia independent of blood oxygen-carrying capacity.

P. Cabrales, M. Intaglietta, J. Martini, 2006, American journal of physiology. Heart and circulatory physiology.

Plasma expander and blood storage effects on capillary perfusion in transfusion after hemorrhage

P. Cabrales, M. Intaglietta, S. Acharya, 2013, Transfusion.

Perfusion vs. oxygen delivery in transfusion with "fresh" and "old" red blood cells: the experimental evidence.

Marcos Intaglietta, Pedro Cabrales, P. Cabrales, 2010, Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis.

MICROCIRCULATORY EFFECTS OF CHANGING BLOOD HEMOGLOBIN OXYGEN AFFINITY DURING HEMORRHAGIC SHOCK RESUSCITATION IN AN EXPERIMENTAL MODEL

P. Cabrales, M. Intaglietta, N. Villela, 2009, Shock.

Blood Substitutes: Evolution from Noncarrying to Oxygen- and Gas-Carrying Fluids

P. Cabrales, M. Intaglietta, 2013, ASAIO journal.

In small cell lung cancer patients treated with RRx-001, a downregulator of CD47, decreased expression of PD-L1 on circulating tumor cells significantly correlates with clinical benefit

J. Trepel, P. Cabrales, T. Reid, 2021, Translational lung cancer research.

Nitric oxide protection against murine cerebral malaria is associated with improved cerebral microcirculatory physiology.

John A. Frangos, Pedro Cabrales, J. Frangos, 2011, The Journal of infectious diseases.

Sustained release nitric oxide from long-lived circulating nanoparticles.

J. Friedman, A. Friedman, P. Cabrales, 2010, Free radical biology & medicine.

Tissue oxygenation after exchange transfusion with ultrahigh-molecular-weight tense- and relaxed-state polymerized bovine hemoglobins.

A. Palmer, P. Cabrales, D. Harris, 2010, American journal of physiology. Heart and circulatory physiology.

Effects of the molecular mass of tense-state polymerized bovine hemoglobin on blood pressure and vasoconstriction.

A. Palmer, P. Cabrales, M. Intaglietta, 2009, Journal of applied physiology.

no-flow conditions Oxygen release from arterioles with normal flow and

R. Pittman, P. Cabrales, M. Intaglietta, 2015 .

The physics of oxygen delivery: facts and controversies.

P. Cabrales, M. Intaglietta, A. Tsai, 2010, Antioxidants & redox signaling.

Microvascular perspective of oxygen-carrying and -noncarrying blood substitutes.

P. Cabrales, M. Intaglietta, A. Tsai, 2006, Annual review of biomedical engineering.

Oxygen release from arterioles with normal flow and no-flow conditions.

P. Cabrales, M. Intaglietta, A. Tsai, 2006, Journal of applied physiology.

Microvascular oxygen delivery and consumption following treatment with verapamil.

P. Cabrales, M. Intaglietta, B. Friesenecker, 2005, American journal of physiology. Heart and circulatory physiology.

Microvascular oxygen distribution in awake hamster window chamber model during hyperoxia.

Marcos Intaglietta, Pedro Cabrales, R. Winslow, 2003, American journal of physiology. Heart and circulatory physiology.

Effect of oxygenated polyethylene glycol decorated hemoglobin on microvascular diameter and functional capillary density in the transgenic mouse model of sickle cell anemia

R. Winslow, P. Cabrales, M. Intaglietta, 2015, Artificial cells, nanomedicine, and biotechnology.

Low oxygen-affinity hemoglobin solution increases oxygenation of partially ischemic tissue during acute anemia.

P. Cabrales, 2010, Journal of the American College of Surgeons.

Dissociation of local nitric oxide concentration and vasoconstriction in the presence of cell-free hemoglobin oxygen carriers.

B. Manjula, R. Winslow, P. Cabrales, 2006, Blood.

Oxygen delivery and consumption in the microcirculation after extreme hemodilution with perfluorocarbons

J. Frangos, P. Cabrales, M. Intaglietta, 2004 .

Radial displacement of red blood cells during hemodilution and the effect on arteriolar oxygen profile.

P. Cabrales, M. Intaglietta, J. Briceño, 2004, American journal of physiology. Heart and circulatory physiology.

Navigating the “No Man's Land” of TKI-Failed EGFR-Mutated Non–Small Cell Lung Cancer (NSCLC): A Review

P. Ma, A. Oronsky, P. Cabrales, 2017, Neoplasia.

RESUSCITATION FROM HEMORRHAGIC SHOCK WITH MalPEG-ALBUMIN: COMPARISON WITH MalPEG-HEMOGLOBIN

R. Winslow, P. Cabrales, M. Intaglietta, 2004, Shock.

Microvascular perfusion upon exchange transfusion with stored red blood cells in normovolemic anemic conditions

P. Cabrales, M. Intaglietta, A. Tsai, 2004, Transfusion.

Autoregulation and mechanotransduction control the arteriolar response to small changes in hematocrit.

D. Tartakovsky, P. Cabrales, M. Intaglietta, 2012, American journal of physiology. Heart and circulatory physiology.

Cardiac systolic function recovery after hemorrhage determines survivability during shock.

P. Cabrales, S. Chatpun, 2011, The Journal of trauma.

Oxygen-carrying blood substitutes: a microvascular perspective

P. Cabrales, M. Intaglietta, A. Tsai, 2004, Expert opinion on biological therapy.

Examining and mitigating acellular hemoglobin vasoactivity.

P. Cabrales, 2013, Antioxidants & redox signaling.

POLYMERIZED BOVINE HEMOGLOBIN CAN IMPROVE SMALL-VOLUME RESUSCITATION FROM HEMORRHAGIC SHOCK IN HAMSTERS

P. Cabrales, M. Intaglietta, A. Tsai, 2009, Shock.

Cardiovascular benefits in moderate increases of blood and plasma viscosity surpass those associated with lowering viscosity: Experimental and clinical evidence.

P. Johnson, P. Cabrales, M. Intaglietta, 2010, Clinical hemorheology and microcirculation.

Beneficial effects due to increasing blood and plasma viscosity.

P. Cabrales, M. Intaglietta, J. Martini, 2006, Clinical hemorheology and microcirculation.

RESUSCITATION FROM HEMORRHAGIC SHOCK WITH HYDROXYETHYL STARCH AND COAGULATION CHANGES

P. Cabrales, M. Intaglietta, A. Tsai, 2007, Shock.

HYPEROSMOTIC-HYPERONCOTIC VERSUS HYPEROSMOTIC-HYPERVISCOUS: SMALL VOLUME RESUSCITATION IN HEMORRHAGIC SHOCK

P. Cabrales, M. Intaglietta, A. Tsai, 2004, Shock.

Microvascular benefits of increasing plasma viscosity and maintaining blood viscosity: counterintuitive experimental findings.

P. Cabrales, M. Intaglietta, J. Martini, 2009, Biorheology.

Improved resuscitation from hemorrhagic shock with Ringer's lactate with increased viscosity in the hamster window chamber model.

P. Cabrales, M. Intaglietta, N. Villela, 2011, The Journal of trauma.

Microvascular pressure and functional capillary density in extreme hemodilution with low- and high-viscosity dextran and a low-viscosity Hb-based O2 carrier.

P. Cabrales, M. Intaglietta, A. Tsai, 2004, American journal of physiology. Heart and circulatory physiology.

Deferoxamine lowers tissue damage after 80% exchange transfusion with polymerized hemoglobin.

P. Cabrales, M. Intaglietta, A. Tsai, 2006, Antioxidants & redox signaling.

Integration of cardiovascular regulation by the blood/endothelium cell‐free layer

Marcos Intaglietta, Pedro Cabrales, D. Tartakovsky, 2011, Wiley interdisciplinary reviews. Systems biology and medicine.

Blood pressure directly correlates with blood viscosity in diabetes type 1 children but not in normals.

P. Cabrales, M. Intaglietta, M. A. Vázquez, 2010, Clinical hemorheology and microcirculation.

Elevated plasma viscosity in extreme hemodilution increases perivascular nitric oxide concentration and microvascular perfusion.

D. Buerk, J. Frangos, P. Cabrales, 2005, American journal of physiology. Heart and circulatory physiology.

A Review on Microvascular Hemodynamics: The Control of Blood Flow Distribution and Tissue Oxygenation.

Alexander T. Williams, Alfredo Lucas, P. Cabrales, 2020, Critical care clinics.

Balance between vasoconstriction and enhanced oxygen delivery

Marcos Intaglietta, Pedro Cabrales, P. Cabrales, 2008, Transfusion.

RRx-001: a systemically non-toxic M2-to-M1 macrophage stimulating and prosensitizing agent in Phase II clinical trials

Hongjuan Zhao, S. Kesari, W. Fitch, 2017, Expert opinion on investigational drugs.

RRx-001 Reset: Chemoresensitization via NO-Mediated M1 Macrophage Repolarization

J. Trepel, R. Day, A. Oronsky, 2017 .

Targeting tumor hypoxia with the epigenetic anticancer agent, RRx-001: a superagonist of nitric oxide generation

A. Oronsky, P. Cabrales, M. Fens, 2016, Medical Oncology.

Safety and activity of RRx-001 in patients with advanced cancer: a first-in-human, open-label, dose-escalation phase 1 study.

R. Korn, W. Fitch, H. Burris, 2015, The Lancet. Oncology.

Phase 1 pilot study of RRx-001 + nivolumab in patients with advanced metastatic cancer (PRIMETIME)

P. Cabrales, T. Reid, B. Oronsky, 2023, Frontiers in Immunology.

RRx-001, a downregulator of the CD47- SIRPα checkpoint pathway, does not cause anemia or thrombocytopenia

A. Oronsky, P. Cabrales, T. Reid, 2021, Expert opinion on drug metabolism & toxicology.

Desperate Times, Desperate Measures: The Case for RRx-001 in the Treatment of COVID-19

A. Oronsky, P. Cabrales, T. Reid, 2020, Seminars in Oncology.

A Review of Clinical Radioprotection and Chemoprotection for Oral Mucositis

A. Oronsky, P. Cabrales, S. Goyal, 2018, Translational oncology.

The macrophage stimulating anti-cancer agent, RRx-001, protects against ischemia-reperfusion injury

J. Trepel, A. Oronsky, P. Cabrales, 2017, Expert review of hematology.

RRx-001, A novel dinitroazetidine radiosensitizer

M. Bednarski, D. Peehl, A. Oronsky, 2016, Investigational New Drugs.

From METS to malaria: RRx-001, a multi-faceted anticancer agent with activity in cerebral malaria

P. Cabrales, B. Oronsky, J. Scicinski, 2015, Malaria Journal.

RRx-001 in Refractory Small-Cell Lung Carcinoma: A Case Report of a Partial Response after a Third Reintroduction of Platinum Doublets

A. Oronsky, P. Cabrales, T. Reid, 2016, Case Reports in Oncology.

Turning on the Radio: Epigenetic Inhibitors as Potential Radiopriming Agents

A. Oronsky, P. Cabrales, T. Reid, 2016, Biomolecules.

Microhemodynamic aberrations created by transfusion of stored blood

P. Cabrales, O. Yalcin, D. Ortiz, 2014, Transfusion.

GBT440 improves red blood cell deformability and reduces viscosity of sickle cell blood under deoxygenated conditions.

P. Cabrales, K. Dufu, D. Oksenberg, 2018, Clinical hemorheology and microcirculation.

Perfluorocarbon in microcirculation during ischemia reperfusion.

P. Cabrales, M. Intaglietta, A. Tsai, 2007, Journal of the American College of Surgeons.

transfusion with hemoglobin-based oxygen carriers Blood volume and cardiac index in rats after exchange

K. Ryan, B. Manjula, K. Vandegriff, 2015 .

Reversal of hemoglobin-induced vasoconstriction with sustained release of nitric oxide.

J. Friedman, A. Friedman, P. Cabrales, 2011, American journal of physiology. Heart and circulatory physiology.

Influence of serological factors and BMI on the blood pressure/hematocrit association in healthy young men and women

S. Subramaniam, G. Escobedo, P. Cabrales, 2014, Vascular health and risk management.

Increased cardiac output and microvascular blood flow during mild hemoconcentration in hamster window model.

P. Cabrales, M. Intaglietta, J. Martini, 2006, American journal of physiology. Heart and circulatory physiology.

Nonobese, exercising children diagnosed with dyslipidemia have normal C-reactive protein

P. Cabrales, M. Intaglietta, M. A. Vázquez, 2008, Vascular health and risk management.

RRx-001 protects against cisplatin-induced toxicities

A. Oronsky, P. Cabrales, T. Reid, 2017, Journal of Cancer Research and Clinical Oncology.

A Partial Response to Reintroduced Chemotherapy in a Resistant Small Cell Lung Cancer Patient After Priming with RRx-001

J. Trepel, R. Day, A. Oronsky, 2016, Clinical Medicine Insights. Oncology.

Cardioprotective Effect of Phase 3 Clinical Anticancer Agent, RRx-001, in Doxorubicin-Induced Acute Cardiotoxicity in Mice.

P. Cabrales, B. Oronsky, C. Carter, 2019, Molecular pharmaceutics.

The effects of acute nitric oxide synthase inhibition on systemic circulation and organ blood flow

P. Cabrales, S. Chatpun, 2012, The 5th 2012 Biomedical Engineering International Conference.

Microcirculatory changes during chronic adaptation to hypoxia.

P. Cabrales, M. Intaglietta, E. Saldívar, 2003, American journal of physiology. Heart and circulatory physiology.

Lowering of blood pressure by increasing hematocrit with non nitric oxide scavenging red blood cells.

P. Cabrales, M. Intaglietta, B. S. Salazar Vázquez, 2008, American journal of respiratory cell and molecular biology.

Extreme hemodilution with PEG-hemoglobin vs. PEG-albumin.

R. Winslow, P. Cabrales, M. Intaglietta, 2005, American journal of physiology. Heart and circulatory physiology.

Effects of extreme hemodilution with hemoglobin-based O2 carriers on microvascular pressure.

R. Winslow, P. Cabrales, M. Intaglietta, 2005, American journal of physiology. Heart and circulatory physiology.

Partial response to carboplatin in an RRx-001 pretreated patient with EGFR-inhibitor-resistance and T790M-negative NSCLC

Pedro Cabrales, Jan Scicinski, Bryan Oronsky, 2016, Respiratory medicine case reports.

Blood Quality Diagnostic Device Detects Storage Differences Between Donors

Vivek P. Jani, Shawn Mailo, Ali Athar, 2017, IEEE Transactions on Biomedical Circuits and Systems.

Microlymphatic and tissue oxygen tension in the rat mesentery.

P. Cabrales, M. Intaglietta, J. Briceño, 2004, American journal of physiology. Heart and circulatory physiology.

Hepatocyte-specific HIF-1α ablation improves obesity-induced glucose intolerance by reducing first-pass GLP-1 degradation

P. Cabrales, M. Riopel, Y. S. Lee, 2019, Science Advances.

Hexa-thiocarbamoyl Phenyl PEG5K Hb: Vasoactivity and Structure

B. Manjula, M. Prabhakaran, Fantao Meng, 2009, The protein journal.

Rockets, radiosensitizers, and RRx-001: an origin story part I.

M. Bednarski, D. Peehl, A. Oronsky, 2016, Discovery medicine.

A Review of RRx-001: A Late-Stage Multi-Indication Inhibitor of NLRP3 Activation and Chronic Inflammation

J. O'Sullivan, P. Cabrales, T. Reid, 2023, Drugs.

Abstract 1420: RRx-001 inhibits glucose erythrocyte and tumor glucose 6-phosphate dehydrogenase

P. Cabrales, B. Oronsky, J. Scicinski, 2014 .

Knockdown of Ant2 Reduces Adipocyte Hypoxia And Improves Insulin Resistance in Obesity

Jong Bae Seo, S. Klein, J. Olefsky, 2018, Nature Metabolism.

Perfusion pressure and blood flow determine microvascular apparent viscosity

Alexander T. Williams, P. Cabrales, O. Yalcin, 2015, Experimental physiology.

Increases in core temperature counterbalance effects of haemoconcentration on blood viscosity during prolonged exercise in the heat

Alexander T. Williams, P. Cabrales, M. Buono, 2016, Experimental physiology.

Hemodynamics and tissue oxygenation after hemodilution with ultrahigh molecular weight polymerized albumin.

A. Palmer, P. Cabrales, D. Ortiz, 2014, Minerva anestesiologica.

Small-volume resuscitation from hemorrhagic shock with polymerized human serum albumin.

A. Palmer, P. Cabrales, O. Yalcin, 2012, The American journal of emergency medicine.

Microvascular experimental evidence on the relative significance of restoring oxygen carrying capacity vs. blood viscosity in shock resuscitation.

P. Cabrales, M. Intaglietta, R. Wettstein, 2008, Biochimica et biophysica acta.

Oxygen transport during hemodilution with a perfluorocarbon-based oxygen carrier: effect of altitude and hyperoxia.

P. Cabrales, M. Intaglietta, J. Briceño, 2008, Journal of applied physiology.

Delaying Blood Transfusion in Experimental Acute Anemia With Perfluorocarbon Emulsion

P. Cabrales, J. Briceño, 2012 .

Oxygen delivery and consumption in the microcirculation after extreme hemodilution with perfluorocarbons.

J. Frangos, P. Cabrales, M. Intaglietta, 2004, American journal of physiology. Heart and circulatory physiology.

Low dose nitrite enhances perfusion after fluid resuscitation from hemorrhagic shock

P. Cabrales, 2009, Resuscitation.

EARLY DIFFERENCE IN TISSUE PH AND MICROVASCULAR HEMODYNAMICS IN HEMORRHAGIC SHOCK RESUSCITATION USING POLYETHYLENE GLYCOL-ALBUMIN- AND HYDROXYETHYL STARCH-BASED PLASMA EXPANDERS

B. Manjula, P. Cabrales, M. Intaglietta, 2005, Shock.

INCREASE PLASMA VISCOSITY SUSTAINS MICROCIRCULATION AFTER RESUSCITATION FROM HEMORRHAGIC SHOCK AND CONTINUOUS BLEEDING

P. Cabrales, M. Intaglietta, A. Tsai, 2005, Shock.

Intaglietta limits oxygen delivery due to vasoconstriction solutionconcentrations of low oxygen affinity hemoglobin

Marcos, P. Cabrales, A. Tsai, 2014 .

Transport of nitric oxide by perfluorocarbon emulsion

P. Cabrales, D. Ortiz, J. C. Briceño, 2013, Biotechnology progress.

Isovolemic exchange transfusion with increasing concentrations of low oxygen affinity hemoglobin solution limits oxygen delivery due to vasoconstriction.

P. Cabrales, M. Intaglietta, A. Tsai, 2008, American journal of physiology. Heart and circulatory physiology.

Measurement of the cardiac output in small animals by thermodilution.

P. Cabrales, M. Intaglietta, A. Tsai, 2003, Microvascular research.

S-nitrosoglutathione Prevents Experimental Cerebral Malaria

J. Frangos, P. Cabrales, L. Carvalho, 2012, Journal of Neuroimmune Pharmacology.

Volume resuscitation from hemorrhagic shock with albumin and hexaPEGylated human serum albumin.

P. Cabrales, M. Intaglietta, S. Acharya, 2008, Resuscitation.

Survival time in severe hemorrhagic shock after perioperative hemodilution is longer with PEG-conjugated human serum albumin than with HES 130/0.4: a microvascular perspective

P. Cabrales, M. Intaglietta, J. Martini, 2008, Critical care.

OXYGEN CARRIERS VASOCONSTRICTION IN THE PRESENCE OF CELL-FREE HEMOGLOBIN DISSOCIATION OF LOCAL NITRIC OXIDE CONCENTRATION AND

B. Manjula, R. Winslow, P. Cabrales, 2013 .

Emergent behaviors in RBCs flows in micro-channels using digital particle image velocimetry.

M Intaglietta, M Bucolo, F Cairone, 2018, Microvascular research.

Implications Enzymatic Degradation of the Endothelial Glycocalyx on the Microvascular Hemodynamics and the Arteriolar Red Cell Free Layer of the Rat Cremaster Muscle

P. Cabrales, V. Jani, O. Yalcin, 2018, Front. Physiol..

Prony Analysis of Left Ventricle Pressure and Volume.

Alexander T. Williams, P. Cabrales, V. Jani, 2023, Medical engineering & physics.

The Double-Edged Sword of Erythrocytes in Health and Disease via Their Adhesiveness

R. Asaro, P. Cabrales, B. Buttari, 2023, International journal of molecular sciences.

Senp1 drives hypoxia-induced polycythemia via GATA1 and Bcl-xL in subjects with Monge’s disease

V. Bafna, R. Ronen, G. Haddad, 2016, The Journal of experimental medicine.

Data Management 101 for Drug Developers: A Peek Behind the Curtain.

P. Cabrales, T. Reid, B. Oronsky, 2023, Clinical and translational science.

Brief report: RRx-001 is a c-Myc inhibitor that targets cancer stem cells

A. Oronsky, P. Cabrales, T. Reid, 2018, Oncotarget.

The direct NLRP3 inhibitor and Phase 3 small molecule anticancer agent, RRx‐001, protects aged triple transgenic Alzheimer’s disease model mice from CNS degeneration and cognitive decline

P. Cabrales, T. Reid, B. Oronsky, 2022, Alzheimer's & Dementia.

The NLRP3 inhibitor and Nrf2 Agonist, RRx-001, Ameliorates Non-alcoholic Fatty Liver Disease in Rats

P. Cabrales, T. Reid, B. Oronsky, 2022, Journal of Clinical Lipidology.

RRx-001, an epigenetic-based radio- and chemosensitizer, has vascular normalizing effects on SCCVII and U87 tumors

P. Cabrales, B. Oronsky, J. Scicinski, 2016, Clinical Epigenetics.

RRx-001, a novel clinical-stage chemosensitizer, radiosensitizer, and immunosensitizer, inhibits glucose 6-phosphate dehydrogenase in human tumor cells.

A. Oronsky, P. Cabrales, T. Reid, 2016, Discovery medicine.

Immune Reactivity and Pseudoprogression or Tumor Flare in a Serially Biopsied Neuroendocrine Patient Treated with the Epigenetic Agent RRx-001

P. Cabrales, T. Reid, B. Oronsky, 2016, Case Reports in Oncology.

Will fixing the vasoactivity caused by hemoglobin-based oxygen carriers be enough?

P. Cabrales, A. Tsai, 2009, Critical care medicine.

Microvascular Po2 during extreme hemodilution with hemoglobin site specifically PEGylated at Cys-93(β) in hamster window chamber

B. Manjula, P. Cabrales, M. Intaglietta, 2004 .

Excessive Erythrocytosis Does Not Elevate Capillary Oxygen Delivery in Subcutaneous Mouse Tissue

M. Gassmann, P. Cabrales, T. Frietsch, 2007, Microcirculation.

Posttransfusion Increase of Hematocrit per se Does Not Improve Circulatory Oxygen Delivery due to Increased Blood Viscosity

J. Friedman, D. Tartakovsky, D. Spahn, 2017, Anesthesia and analgesia.

Do Skeletal Dynamics Mediate Sugar Uptake and Transport in Human Erythrocytes?

R. Asaro, P. Cabrales, A. Carruthers, 2018, Biophysical journal.

The variability of blood pressure due to small changes of hematocrit.

P. Cabrales, M. Intaglietta, J. Martini, 2010, American journal of physiology. Heart and circulatory physiology.

Hemorheological implications of perfluorocarbon based oxygen carrier interaction with colloid plasma expanders and blood

P. Cabrales, O. Alvarez, J. Briceño, 2013, Biotechnology progress.

Chapter 8 – Shear Stress Mechanotransduction and the Flow Properties of Blood

J. Frangos, P. Cabrales, M. Intaglietta, 2006 .

Polymerized human hemoglobin increases the effectiveness of cisplatin-based chemotherapy in non-small cell lung cancer

Alexander T. Williams, A. Palmer, Alfredo Lucas, 2020, Oncotarget.

Blood pressure reduction due to hemoglobin glycosylation in type 2 diabetic patients

M. Rodríguez-Moran, F. Guerrero‐Romero, P. Cabrales, 2008, Vascular health and risk management.

Plasma expander viscosity effects on red cell-free layer thickness after moderate hemodilution.

A. Palmer, P. Cabrales, O. Yalcin, 2011, Biorheology.

Rrx-001 Is a Phase 3 Small Molecule Dual Inhibitor of CD47 and Sirpα with Activity in Multiple Myeloma

P. Cabrales, T. Reid, B. Oronsky, 2018, Blood.

Increased plasma viscosity prolongs microhemodynamic conditions during small volume resuscitation from hemorrhagic shock.

P. Cabrales, M. Intaglietta, A. Tsai, 2008, Resuscitation.

Knockdown of Ant2 Reduces Adipocyte Hypoxia And Improves Insulin Resistance in Obesity

Jong Bae Seo, S. Klein, J. Olefsky, 2018, Nature Metabolism.

Flushing Out Carcinoid Syndrome: Beneficial Effect of the Anticancer Epigenetic Agent RRx-001 in a Patient with a Treatment-Refractory Neuroendocrine Tumor

A. Oronsky, P. Cabrales, T. Reid, 2015, Case Reports in Oncology.

Cardiac-specific knockout and pharmacological inhibition of Endothelin receptor type B lead to cardiac resistance to extreme hypoxia

Alexander T. Williams, G. Haddad, Dan Zhou, 2018, Journal of molecular medicine.

Partial Response to Platinum Doublets in Refractory EGFR-Positive Non-Small Cell Lung Cancer Patients after RRx-001: Evidence of Episensitization

P. Cabrales, T. Reid, B. Oronsky, 2016, Case Reports in Oncology.

Impact of Enzymatic Degradation of the Endothelial Glycocalyx on Vascular Permeability in an Awake Hamster Model

P. Cabrales, M. Intaglietta, S. A. Landsverk, 2012, Critical care research and practice.

Increased plasma viscosity prolongs microhemodynamic conditions during small volume resuscitation from hemorrhagic shock.

P. Cabrales, M. Intaglietta, A. Tsai, 2008, Resuscitation.

Nonobese, exercising children diagnosed with dyslipidemia have normal C-reactive protein

P. Cabrales, M. A. Vázquez, B. Y. S. Vázquez, 2008, Vascular health and risk management.

NO supplementation for transfusion medicine and cardiovascular applications

J. Friedman, P. Cabrales, D. Ortiz, 2015, Future science OA.

Effect of oxygenated polyethylene glycol decorated hemoglobin on microvascular diameter and functional capillary density in the transgenic mouse model of sickle cell anemia

R. Winslow, P. Cabrales, M. Intaglietta, 2015, Artificial cells, nanomedicine, and biotechnology.

Tissue oxidative metabolism after extreme hemodilution with PEG-conjugated hemoglobin.

P. Cabrales, S. Acharya, Fantao Meng, 2010, Journal of applied physiology.

Can the effects of vasoactivity of molecular hemoglobin-based plasma expanders be ignored?

P. Cabrales, A. Tsai, 2006, Critical care medicine.

Effect of oxygen consumption by measuring method on PO2 transients associated with the passage of erythrocytes in capillaries of rat mesentery.

R. Pittman, P. Cabrales, M. Intaglietta, 2005, American journal of physiology. Heart and circulatory physiology.

Delaying Blood Transfusion in Experimental Acute Anemia with a Perfluorocarbon Emulsion

P. Cabrales, Juan Carlos Briceño, 2011, Anesthesiology.

Blood pressure reduction due to hemoglobin glycosylation in type 2 diabetic patients

M. Rodríguez-Moran, P. Cabrales, M. Intaglietta, 2008 .

Do Skeletal Dynamics Mediate Sugar Uptake and Transport in Human Erythrocytes?

R. Asaro, P. Cabrales, A. Carruthers, 2018, Biophysical journal.

GBT 1118 , a potent allosteric modifier of hemoglobin oxygen affinity increases 1 tolerance to severe hypoxia in mice

P. Cabrales, P. Cabrales, K. Dufu, 2017 .

RRx-001 Priming of PD-1 Inhibition in the Treatment of Small Cell Carcinoma of the Vagina: A Rare Gynecological Tumor

J. Trepel, R. Day, P. Cabrales, 2017, Case Reports in Oncology.

of red blood cells flowing in venules Effect of aggregation and shear rate on the dispersion

A. Popel, O. Baskurt, H. Meiselman, 2005 .

after a comparison between in vivo microvascular formation and

P. Cabrales, A. Tsai, Marcos Intaglietta, 2013 .

Perfusion pressure and blood flow determine microvascular apparent viscosity

Alexander T. Williams, P. Cabrales, O. Yalcin, 2015, Experimental physiology.

Microvascular experimental evidence on the relative significance of restoring oxygen carrying capacity vs. blood viscosity in shock resuscitation.

P. Cabrales, M. Intaglietta, R. Wettstein, 2008, Biochimica et biophysica acta.