A. Seelig

发表

Neutron diffraction studies on selectively deuterated phospholipid bilayers

G. Zaccai, J. Seelig, G. Büldt, 1978, Nature.

Neutron diffraction studies on phosphatidylcholine model membranes. II. Chain conformation and segmental disorder.

G Büldt, G. Zaccai, J. Seelig, 1979, Journal of molecular biology.

Inhibitors of multidrug efflux transporters: their membrane and protein interactions.

A. Seelig, E. Gatlik-Landwojtowicz, A Seelig, 2005, Mini reviews in medicinal chemistry.

Bilayers of dipalmitoyl-3-sn-phosphatidylcholine. Conformational differences between the fatty acyl chains.

J. Seelig, A. Seelig, 1975, Biochimica et biophysica acta.

Lipid conformation in model membranes and biological membranes

J. Seelig, A. Seelig, J Seelig, 1980, Quarterly Reviews of Biophysics.

Label-free assay for the assessment of nonspecific binding of positron emission tomography tracer candidates.

A. Seelig, E. Borroni, H. Fischer, 2015, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Protein transduction domains of HIV-1 and SIV TAT interact with charged lipid vesicles. Binding mechanism and thermodynamic analysis.

J. Seelig, A. Seelig, A. Ziegler, 2003, Biochemistry.

A general pattern for substrate recognition by P-glycoprotein.

A. Seelig, 1998, European journal of biochemistry.

P-Glycoprotein: One Mechanism, Many Tasks and the Consequences for Pharmacotherapy of Cancers

A. Seelig, 2020, Frontiers in Oncology.

The brain entry of HIV-1 protease inhibitors is facilitated when used in combination.

M. Battegay, C. Marzolini, A. Seelig, 2013, Molecular pharmaceutics.

P-glycoprotein-ATPase modulation: the molecular mechanisms.

A. Seelig, A. Beck, X. Li-Blatter, 2012, Biophysical journal.

Detergents as intrinsic P-glycoprotein substrates and inhibitors.

Anna Seelig, Xiaochun Li-Blatter, A. Seelig, 2009, Biochimica et biophysica acta.

Toward Understanding P‐Glycoprotein Structure–Activity Relationships

A. Seelig, 2008 .

P-glycoprotein senses its substrates and the lateral membrane packing density: consequences for the catalytic cycle.

A. Seelig, E. Gatlik-Landwojtowicz, Päivi Aänismaa, 2008, Biochemistry.

Paclitaxel succinate analogs: Anionic and amide introduction as a strategy to impart blood-brain barrier permeability.

R. Himes, K. Audus, G. Georg, 2008, Bioorganic & medicinal chemistry letters.

The Role of Size and Charge for Blood–Brain Barrier Permeation of Drugs and Fatty Acids

Anna Seelig, A. Seelig, 2007, Journal of Molecular Neuroscience.

Single-site chemical modification at C10 of the baccatin III core of paclitaxel and Taxol C reduces P-glycoprotein interactions in bovine brain microvessel endothelial cells.

R. Himes, K. Audus, G. Georg, 2006, Bioorganic & medicinal chemistry letters.

Interaction of verapamil with lipid membranes and P-glycoprotein: connecting thermodynamics and membrane structure with functional activity.

J. Seelig, A. Seelig, X. L. Blatter, 2006, Biophysical journal.

Quantification and characterization of P-glycoprotein-substrate interactions.

Anna Seelig, A. Seelig, E. Gatlik-Landwojtowicz, 2006, Biochemistry.

Structure-activity relationship of P-glycoprotein substrates and modifiers.

A. Seelig, A Seelig, E. Landwojtowicz, 2000, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Blood-Brain Barrier Permeation: Molecular Parameters Governing Passive Diffusion

A. Seelig, H. Fischer, R. Gottschlich, 1998, The Journal of Membrane Biology.

How does P-glycoprotein recognize its substrates?

A. Seelig, 1998, International journal of clinical pharmacology and therapeutics.

Carrier Mediated Distribution System (CAMDIS): a new approach for the measurement of octanol/water distribution coefficients.

M. Kansy, A. Seelig, H. Fischer, 2015, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Deuterium magnetic resonance studies of phospholipid bilayers.

J. Seelig, A. Seelig, 1974, Biochemical and biophysical research communications.

Real-time monitoring of P-glycoprotein activation in living cells.

A. Seelig, P. Nervi, E. Landwojtowicz, 2002, Biochemistry.

Copper and manganese electron spin resonance studies of cytochrome c oxidase from Paracoccus denitrificans.

J. Seelig, A. Seelig, B. Ludwig, 1981, Biochimica et biophysica acta.

Phospholipid composition and organization of cytochrome c oxidase preparations as determined by 31P-nuclear magnetic resonance.

J. Seelig, A. Seelig, 1985, Biochimica et biophysica acta.

Molecular determinants of the reversible membrane anchorage of the G-protein transducin.

A. Seelig, K. Hofmann, M. Heck, 1999, Biochemistry.

Binding of a neuropeptide, substance P, to neutral and negatively charged lipids.

A. Seelig, P. Macdonald, 1989, Biochemistry.

Octyl-beta-D-glucopyranoside partitioning into lipid bilayers: thermodynamics of binding and structural changes of the bilayer.

M. Wenk, J. Seelig, A. Seelig, 1997, Biophysical journal.

The rate of P-glycoprotein activation depends on the metabolic state of the cell.

A. Seelig, E. Gatlik-Landwojtowicz, Päivi Aänismaa, 2004, Biochemistry.

P-glycoprotein substrate transport assessed by comparing cellular and vesicular ATPase activity.

A. Seelig, P. Nervi, X. Li-Blatter, 2010, Biochimica et biophysica acta.

High Relaxivity for Monomeric Gd(DOTA)‐Based MRI Contrast Agents, Thanks to Micellar Self‐Organization

A. Seelig, H. Fischer, É. Tóth, 1999 .

IRIV-adjuvanted hepatitis A vaccine: in vivo absorption and biophysical characterization.

A. Seelig, R. Glück, R. Zurbriggen, 2000, Progress in lipid research.

Binding of hisactophilin I and II to lipid membranes is controlled by a pH-dependent myristoyl-histidine switch.

G. Gerisch, A. Seelig, F. Hanakam, 1996, Biochemistry.

Phospholipid Binding of Synthetic Talin Peptides Provides Evidence for an Intrinsic Membrane Anchor of Talin*

A. Seelig, G. Isenberg, X. L. Blatter, 2000, The Journal of Biological Chemistry.

Unraveling membrane-mediated substrate-transporter interactions.

A. Seelig, 2006, Biophysical journal.

Local anesthetics and pressure: a comparison of dibucaine binding to lipid monolayers and bilayers.

A. Seelig, Anna Seelig, 1987, Biochimica et biophysica acta.

Halogenation of Drugs Enhances Membrane Binding and Permeation

Grégori Gerebtzoff, Anna Seelig, Holger Fischer, 2004, Chembiochem : a European journal of chemical biology.

The dynamic structure of fatty acyl chains in a phospholipid bilayer measured by deuterium magnetic resonance.

J. Seelig, A. Seelig, J Seelig, 1974, Biochemistry.

New Drugs for the Na+/H+ Exchanger. Influence of Na+ Concentration and Determination of Inhibition Constants with a Microphysiometer

J. Seelig, A. Seelig, N. Beier, 1999, Journal of Membrane Biology.

Binding of substance P agonists to lipid membranes and to the neurokinin-1 receptor.

A. Seelig, G. Hölzemann, S. Lotz, 1996, Biochemistry.

Interaction of a substance P agonist and of substance P antagonists with lipid membranes. A thermodynamic analysis.

A. Seelig, 1992, Biochemistry.

Enhancement of drug absorption by noncharged detergents through membrane and P-glycoprotein binding

Grégori Gerebtzoff, Anna Seelig, A. Seelig, 2006, Expert opinion on drug metabolism & toxicology.

Effect of a single cis double bond on the structures of a phospholipid bilayer.

J. Seelig, A. Seelig, J Seelig, 1977, Biochemistry.

Lipid-protein interaction in reconstituted cytochrome c oxidase/phospholipid membranes.

J. Seelig, A. Seelig, 1978, Hoppe-Seyler's Zeitschrift fur physiologische Chemie.

Partitioning of local anesthetics into membranes: surface charge effects monitored by the phospholipid head-group.

J. Seelig, A. Seelig, P. Allegrini, 1988, Biochimica et biophysica acta.

Allocrite Sensing and Binding by the Breast Cancer Resistance Protein (ABCG2) and P-Glycoprotein (ABCB1).

S. Bernèche, A. Seelig, G. Merino, 2015, Biochemistry.

P-Glycoprotein kinetics measured in plasma membrane vesicles and living cells.

A. Seelig, Päivi Aänismaa, 2007, Biochemistry.

How Phosphorylation and ATPase Activity Regulate Anion Flux though the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)*

A. Seelig, Manuel Hellstern, Cinzia Esposito, 2016, The Journal of Biological Chemistry.

Substance P and antagonists. Surface activity and molecular shapes.

A. Seelig, 1990, Biochimica et biophysica acta.

The Anthelmintic Triclabendazole and Its Metabolites Inhibit the Membrane Transporter ABCG2/BCRP

A. Seelig, G. Merino, B. Barrera, 2012, Antimicrobial Agents and Chemotherapy.

Predicting Activators and Inhibitors of the Breast Cancer Resistance Protein (ABCG2) and P-Glycoprotein (ABCB1) Based on Mechanistic Considerations.

A. Seelig, G. Merino, X. Li-Blatter, 2015, Molecular pharmaceutics.

A method to determine the ability of drugs to diffuse through the blood-brain barrier.

A. Seelig, A Seelig, R Gottschlich, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Sav1866 from Staphylococcus aureus and P-glycoprotein: similarities and differences in ATPase activity assessed with detergents as allocrites.

R. Dawson, K. Locher, A. Seelig, 2013, Biochemistry.

Protein Unfolding—Thermodynamic Perspectives and Unfolding Models

J. Seelig, A. Seelig, 2022, bioRxiv.

On the interaction of ionic detergents with lipid membranes. Thermodynamic comparison of n-alkyl-+N(CH₃)₃ and n-alkyl-SO₄⁻.

J. Seelig, A. Seelig, A. Beck, 2010, The journal of physical chemistry. B.

Protein Stability—Analysis of Heat and Cold Denaturation without and with Unfolding Models

J. Seelig, A. Seelig, 2023, The journal of physical chemistry. B.

Molecular understanding of calorimetric protein unfolding experiments

J. Seelig, A. Seelig, 2021, bioRxiv.

Unidirectional Transport Mechanism in an ATP Dependent Exporter

S. Bernèche, A. Seelig, Yanyan Xu, 2017, ACS central science.

Substance P and Antagonists

A. Seelig, R. Doelz, 1991 .

Quantification and characterization of P-glycoprotein-substrate interactions.

Anna Seelig, A. Seelig, E. Gatlik-Landwojtowicz, 2006, Biochemistry.

Atomic force microscopy reveals defects within mica supported lipid bilayers induced by the amyloidogenic human amylin peptide.

U. Aebi, M. Stolz, A. Seelig, 2004, Journal of molecular biology.

P-glycoprotein (ABCB1) - weak dipolar interactions provide the key to understanding allocrite recognition, binding, and transport

A. Seelig, X. Li-Blatter, 2023, Cancer drug resistance.

Exploring the P-glycoprotein binding cavity with polyoxyethylene alkyl ethers.

A. Seelig, X. Li-Blatter, 2010, Biophysical journal.

In Silico Prediction of Blood-Brain Barrier Permeation Using the Calculated Molecular Cross-Sectional Area as Main Parameter

Grégori Gerebtzoff, Anna Seelig, A. Seelig, 2006, J. Chem. Inf. Model..

The use of monolayers for simple and quantitative analysis of lipid-drug interactions exemplified with dibucaine and substance P.

A. Seelig, 1990, Cell biology international reports.

Cholesterol-induced rod-like motion of fatty acyl chains in lipid bilayers a deuterium magnetic resonance study.

J. Seelig, H. Gally, A. Seelig, 1976, Hoppe-Seyler's Zeitschrift fur physiologische Chemie.

Do substance P agonists insert into the lipid membrane?

G. Barnickel, A. Seelig, J. Harting, 1992, Regulatory Peptides.

Synthesis and interactions of 7-deoxy-, 10-deacetoxy, and 10-deacetoxy-7-deoxypaclitaxel with NCI/ADR-RES cancer cells and bovine brain microvessel endothelial cells.

R. Himes, K. Audus, G. Georg, 2006, Bioorganic & medicinal chemistry letters.

Substrate recognition by P-glycoprotein and the multidrug resistance-associated protein MRP1: a comparison.

A. Seelig, X. L. Blatter, A Seelig, 2000, International journal of clinical pharmacology and therapeutics.

The Q loops of the human multidrug resistance transporter ABCB1 are necessary to couple drug binding to the ATP catalytic cycle

K. Linton, P. Chiba, A. Seelig, 2014, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Chemical protein unfolding - A simple cooperative model

J. Seelig, A. Seelig, 2023, bioRxiv.

31P and 1H NMR Studies of the Molecular Organization of Lipids in the Parallel Artificial Membrane Permeability Assay.

A. Ross, J. Seelig, A. Seelig, 2017, Molecular pharmaceutics.

In Silico Prediction of Blood-Brain Barrier Permeation Using the Calculated Molecular Cross-Sectional Area as Main Parameter

A. Seelig, Grégori Gerebtzoff, 2006, J. Chem. Inf. Model..

Paclitaxel succinate analogs: Anionic and amide introduction as a strategy to impart blood-brain barrier permeability.

R. Himes, K. Audus, A. Seelig, 2008, Bioorganic & medicinal chemistry letters.

The role of the lipid membrane for the function of the ABC transporter P-glycoprotein

A. Seelig, 2007 .

Membrane Structure

A. Seelig, Joachim Seelig, 2003 .