J. Prehn

发表

Mathematical modelling of the mitochondrial apoptosis pathway.

Jakub Wenus, Heiko Duessmann, S. Kilbride, 2011, Biochimica et biophysica acta.

Systems modelling methodology for the analysis of apoptosis signal transduction and cell death decisions.

M. Rehm, J. Prehn, 2013, Methods.

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

S. Lipton, A. Ciechanover, T. Luedde, 2018, Cell Death & Differentiation.

Caspase-3 Cleavage and Nuclear Localization of Caspase-Activated DNase in Human Temporal Lobe Epilepsy

R. Simon, D. Henshall, J. Prehn, 2006, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Apoptosis signaling proteins as prognostic biomarkers in colorectal cancer: a review.

J. Prehn, S. Hector, 2009, Biochimica et biophysica acta.

Expanding the Substantial Interactome of NEMO Using Protein Microarrays

J. Prehn, B. Fenner, Beau J. Fenner, 2010, PloS one.

9-Benzylidene-naphtho[2,3-b]thiophen-4-ones and benzylidene-9(10H)-anthracenones as novel tubulin interacting agents with high apoptosis-inducing activity.

A. Zuse, M. Los, J. Prehn, 2007, European journal of pharmacology.

Genome-wide microRNA profiling of plasma from three different animal models identifies biomarkers of temporal lobe epilepsy

F. Rosenow, N. Delanty, E. Jimenez-Mateos, 2020, Neurobiology of Disease.

Potent and lasting seizure suppression by systemic delivery of antagomirs targeting miR-134 timed with blood-brain barrier disruption

T. Rüber, C. Mooney, D. Henshall, 2019 .

Electrical stimulation of the ventral hippocampal commissure delays experimental epilepsy and is associated with altered microRNA expression

J. Kjems, F. Rosenow, D. Henshall, 2019, Brain Stimulation.

The DAP kinase family of pro‐apoptotic proteins: novel players in the apoptotic game

K. Scheidtmann, D. Kögel, J. Prehn, 2001, BioEssays : news and reviews in molecular, cellular and developmental biology.

Cytoplasmic Inclusions of Htt Exon1 Containing an Expanded Polyglutamine Tract Suppress Execution of Apoptosis in Sympathetic Neurons

A. Tolkovsky, J. Prehn, A. Wyttenbach, 2008, The Journal of Neuroscience.

Apoptosis-Inducing Factor (AIF) in Physiology and Disease: The Tale of a Repented Natural Born Killer

J. Prehn, D. Bano, 2018, EBioMedicine.

Comparative analysis of CI- and CIV-containing respiratory supercomplexes at single-cell resolution

P. Nicotera, J. Prehn, D. Ehninger, 2021, Cell reports methods.

Comparative profiling of N-respirasomes predicts aberrant mitochondrial bioenergetics at single-cell resolution

P. Nicotera, J. Prehn, D. Ehninger, 2020, bioRxiv.

Paraoxonase promoter and intronic variants modify risk of sporadic amyotrophic lateral sclerosis

S. Cronin, O. Hardiman, J. Prehn, 2007, Journal of Neurology, Neurosurgery & Psychiatry.

Control of Motoneuron Survival by Angiogenin

O. Hardiman, C. Concannon, J. Prehn, 2008, The Journal of Neuroscience.

Riluzole does not improve lifespan or motor function in three ALS mouse models

J. Prehn, M. Hogg, L. Halang, 2018, Amyotrophic lateral sclerosis & frontotemporal degeneration.

Orexin-A/hypocretin-1 Immunoreactivity in the Lateral Hypothalamus is Reduced in Genetically Obese but not in Diet-induced Obese Mice

J. Prehn, J. A. González, J. Antonio González, 2018, Neuroscience.

Neuronal cell-based high-throughput screen for enhancers of mitochondrial function reveals luteolin as a modulator of mitochondria-endoplasmic reticulum coupling

David S. Park, D. Ferreira, J. Ruas, 2021, BMC Biology.

Glucose-starved Cells Do Not Engage in Prosurvival Autophagy*

K. Ryan, J. Prehn, A. Caro-Maldonado, 2013, The Journal of Biological Chemistry.

Orexin/hypocretin immunoreactivity in the lateral hypothalamus is reduced in genetically obese but not in diet-induced obese mice

J. Prehn, J. A. González, 2017, bioRxiv.

Endonuclease‐G and the pathways to dopaminergic neurodegeneration: a question of location?

J. Prehn, M. Hogg, 2013, The EMBO journal.

S100B in brain damage and neurodegeneration

V. Arolt, M. Rothermundt, J. Prehn, 2003, Microscopy research and technique.

Central roles of apoptotic proteins in mitochondrial function

J. Prehn, S. M. Kilbride, 2013, Oncogene.

Manifestations of Drug Toxicity on Mitochondria in the Nervous System

J. Prehn, I. Llorente-Folch, Irene Llorente‐Folch, 2018 .

Control of mitochondrial physiology and cell death by the Bcl-2 family proteins Bax and Bok

J. Prehn, B. D'Orsi, J. Mateyka, 2017, Neurochemistry International.

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

S. Lipton, A. Ciechanover, T. Luedde, 2018, Cell Death & Differentiation.

Single-cell imaging of the heat-shock response in colon cancer cells suggests that magnitude and length rather than time of onset determines resistance to apoptosis

H. Düssmann, C. Concannon, T. Bernaś, 2014, Journal of Cell Science.

MicroRNAs in epilepsy: pathophysiology and clinical utility

D. Goldstein, J. Kjems, H. Hamer, 2016, The Lancet Neurology.

Endoplasmic Reticulum Stress and Apoptosis Signaling in Human Temporal Lobe Epilepsy

D. Henshall, J. Prehn, W. Taki, 2006, Journal of neuropathology and experimental neurology.

Mislocalization of Mitochondrial Intermembrane Space Proteins

J. Prehn, Federico Lucantoni, L. Flanagan, 2016 .

Systems Biology of the Mitochondrial Apoptosis Pathway

H. Huber, J. Prehn, C. O'Connor, 2012 .

Dissipation of Potassium and Proton Gradients Inhibits Mitochondrial Hyperpolarization and Cytochrome c Release during Neural Apoptosis

H. Düssmann, D. Kögel, C. Reimertz, 2001, The Journal of Neuroscience.

Mitochondrial Depolarization Is Not Required for Neuronal Apoptosis

J. Prehn, Aaron J. Krohn, Tanja Wahlbrink, 1999, The Journal of Neuroscience.

Staurosporine-Induced Apoptosis of Cultured Rat Hippocampal Neurons Involves Caspase-1-Like Proteases as Upstream Initiators and Increased Production of Superoxide as a Main Downstream Effector

J. Prehn, Aaron J. Krohn, E. Preis, 1998, The Journal of Neuroscience.

Differential expression patterns of Puma and Hsp70 following proteasomal stress in the hippocampus are key determinants of neuronal vulnerability

C. Bonner, M. Ward, C. Concannon, 2010, Journal of neurochemistry.

ANG mutations segregate with familial and 'sporadic' amyotrophic lateral sclerosis

S. Ennis, Robert H. Brown, P. Andersen, 2006, Nature Genetics.

Fibroblast growth factor homologous factor 1 interacts with NEMO to regulate NF-&kgr;B signaling in neurons

T. Bernaś, J. Prehn, C. Jefferies, 2012, Journal of Cell Science.

Mannose metabolism inhibition sensitizes acute myeloid leukemia cells to cytarabine and FLT3 inhibitor therapy by modulating fatty acid metabolism to drive ferroptotic cell death

Pedro Madrigal, B. Huntly, G. Vassiliou, 2023, bioRxiv.

Bcl‐2 homology domain 3‐only proteins Puma and Bim mediate the vulnerability of CA1 hippocampal neurons to proteasome inhibition in vivo

J. Prehn, D. Henshall, M. Ward, 2011, The European journal of neuroscience.

Neuronal Apoptosis: BH3-Only Proteins the Real Killers?

D. Kögel, M. Ward, J. Prehn, 2004, Journal of bioenergetics and biomembranes.

Anti-apoptotic BCL-2 family proteins in acute neural injury

J. Prehn, U. Anilkumar, Ujval Anilkumar, 2014, Front. Cell. Neurosci..

p53 Expression Induces Apoptosis in Hippocampal Pyramidal Neuron Cultures

R. Weichselbaum, J. Prehn, G. Ghadge, 1997, The Journal of Neuroscience.

Identification of polyubiquitin binding proteins involved in NF-kappaB signaling using protein arrays.

J. Prehn, B. Fenner, Beau J. Fenner, 2009, Biochimica et biophysica acta.

The BCL-2 family protein Bid is critical for pro-inflammatory signaling in astrocytes

J. Prehn, Hans-Georg König, S. Kinsella, 2014, Neurobiology of Disease.

tRNA-derived fragments: A new class of non-coding RNA with key roles in nervous system function and dysfunction

M. Helm, J. Prehn, S. Fagan, 2021, Progress in Neurobiology.

Loss of angiogenin function is related to earlier ALS onset and a paradoxical increase in ALS duration

Joseph Peter Salisbury, Joseph P. Salisbury, J. Agar, 2020, Scientific Reports.

AMP‐Activated Protein Kinase (AMPK) as a Cellular Energy Sensor and Therapeutic Target for Neuroprotection

J. Prehn, P. Weisová, S. Pfeiffer, 2015 .

Motoneurons Secrete Angiogenin to Induce RNA Cleavage in Astroglia

Philippe Marin, P. Marin, C. Concannon, 2012, The Journal of Neuroscience.

Angiogenin induces modifications in the astrocyte secretome: relevance to amyotrophic lateral sclerosis.

P. Marin, J. Prehn, S. Urbach, 2013, Journal of proteomics.

Coincident enrichment of phosphorylated IκBα, activated IKK, and phosphorylated p65 in the axon initial segment of neurons

D. Kögel, C. Schultz, J. Prehn, 2006, Molecular and Cellular Neuroscience.

NMDA receptor‐mediated excitotoxic neuronal apoptosis in vitro and in vivo occurs in an ER stress and PUMA independent manner

J. Prehn, D. Henshall, C. Bonner, 2008, Journal of neurochemistry.

Delayed Mitochondrial Dysfunction in Excitotoxic Neuron Death: Cytochrome c Release and a Secondary Increase in Superoxide Production

J. Prehn, J. Krieglstein, Aaron J. Krohn, 2000, The Journal of Neuroscience.

Ceramide‐induced apoptosis of D283 medulloblastoma cells requires mitochondrial respiratory chain activity but occurs independently of caspases and is not sensitive to Bcl‐xL overexpression

D. Kögel, C. Reimertz, J. Prehn, 2002, Journal of neurochemistry.

p75 neurotrophin receptor is required for constitutive and NGF‐induced survival signalling in PC12 cells and rat hippocampal neurones

C. Culmsee, J. Prehn, J. Krieglstein, 2002, Journal of neurochemistry.

Molecular Mechanisms in Amyotrophic Lateral Sclerosis: The Role of Angiogenin, a Secreted RNase

J. Prehn, Isabela M. Aparicio-Erriu, 2012, Front. Neurosci..

Apoptotic cell death in disease—Current understanding of the NCCD 2023

S. Lipton, A. Ciechanover, T. Luedde, 2023, Cell Death & Differentiation.

BH3‐only protein Bid is dispensable for seizure‐induced neuronal death and the associated nuclear accumulation of apoptosis‐inducing factor

N. Plesnila, A. Strasser, D. Henshall, 2010, Journal of neurochemistry.

Reduced hippocampal damage and epileptic seizures after status epilepticus in mice lacking proapoptotic Puma

J. Prehn, E. Jimenez-Mateos, D. Henshall, 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

“Preconditioning” with latrepirdine, an adenosine 5′-monophosphate-activated protein kinase activator, delays amyotrophic lateral sclerosis progression in SOD1G93A mice

J. Prehn, M. Hogg, M. Mitchem, 2015, Neurobiology of Aging.

Caspase modelling to predict personalised risk in stage III colorectal cancer (CRC) patients.

M. Salto‐Tellez, D. Longley, P. Laurent-Puig, 2016 .

A systems model of BCL-2 dependent apoptosis to predict stage II CRC patients benefiting from adjuvant chemotherapy and as a prognostic tool for stage III CRC patients with increased risk of recurrence.

M. Salto‐Tellez, P. Johnston, P. Laurent-Puig, 2016 .

Depletion of 14‐3‐3 zeta elicits endoplasmic reticulum stress and cell death, and increases vulnerability to kainate‐induced injury in mouse hippocampal cultures

D. Henshall, M. Ward, J. Prehn, 2008, Journal of neurochemistry.

Imaging oxygen in neural cell and tissue models by means of anionic cell-permeable phosphorescent nanoparticles

Alexander V. Zhdanov, J. Pakan, I. Klimant, 2014, Cellular and Molecular Life Sciences.

Quantification of substoichiometric modification reveals global tsRNA hypomodification, preferences for angiogenin-mediated tRNA cleavage, and idiosyncratic epitranscriptomes of human neuronal cell-lines

M. Helm, J. Prehn, V. Marchand, 2022, Computational and structural biotechnology journal.

Pleiotropic activity of systemically delivered angiogenin in the SOD1G93A mouse model

J. Prehn, M. Hogg, S. Lewandowski, 2018, Neuropharmacology.

tsRNAsearch: a pipeline for the identification of tRNA and ncRNA fragments from small RNA-sequencing data

Paul D. Donovan, Natalie M. McHale, Morten T. Venø, 2021, Bioinform..

Loss of angiogenin function is related to earlier ALS onset and a paradoxical increase in ALS duration

Joseph Peter Salisbury, J. Agar, J. Prehn, 2020, Scientific Reports.

Correction: Vascular regression precedes motor neuron loss in the FUS (1-359) ALS mouse model

J. Prehn, M. Hogg, S. Lewandowski, 2019, Disease Models & Mechanisms.

Neuronal cell-based high-throughput screen for enhancers of mitochondrial function reveals luteolin as a modulator of mitochondria-endoplasmic reticulum coupling

David S. Park, D. Ferreira, J. Ruas, 2021, BMC biology.

Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes

R A Knight, G Melino, G M Cohen, 2009, Cell Death and Differentiation.

MicroRNAs 10a and 10b are potent inducers of neuroblastoma cell differentiation through targeting of nuclear receptor corepressor 2

R. Stallings, S. Das, J. Prehn, 2011, Cell Death and Differentiation.

Imaging of single cell responses to ER stress indicates that the relative dynamics of IRE1/XBP1 and PERK/ATF4 signalling rather than a switch between signalling branches determine cell survival

H. Düssmann, C. Concannon, J. Prehn, 2015, Cell Death and Differentiation.

KCa2 channels activation prevents [Ca2+]i deregulation and reduces neuronal death following glutamate toxicity and cerebral ischemia

N. Plesnila, C. Culmsee, A. Dolga, 2011, Cell Death and Disease.

Fusobacterium nucleatum associates with stages of colorectal neoplasia development, colorectal cancer and disease outcome

M. Ebert, P. Souček, P. Neary, 2014, European Journal of Clinical Microbiology & Infectious Diseases.

Human IgG antibody profiles differentiate between symptomatic patients with and without colorectal cancer

B. MacCraith, D. Murphy, J. Prehn, 2009, Gut.

Mitochondrial control of neuron death and its role in neurodegenerative disorders

J. Jordán, J. Prehn, J. Prehn, 2003, Journal of Physiology and Biochemistry.

Paracrine control of tissue regeneration and cell proliferation by Caspase-3

J. Prehn, J. Prehn, L. Flanagan, 2013, Cell Death and Disease.

Microsatellite instability and response to neoadjuvant chemoradiotherapy in rectal cancer: A systematic review and meta-analysis.

J. Prehn, J. Prehn, J. Burke, 2020, Surgical oncology.

Identification of circulating microRNAs in HNF1A-MODY carriers

R. Stallings, M. Byrne, J. Prehn, 2013, Diabetologia.

Interrogation of gossypol therapy in glioblastoma implementing cell line and patient-derived tumour models

K. Ligon, J. Prehn, W. Gallagher, 2014, British Journal of Cancer.

A structured approach to the study of metabolic control principles in intact and impaired mitochondria.

H. Huber, J. Prehn, N. Connolly, 2012, Molecular bioSystems.

Hypothesis review: are clathrin-mediated endocytosis and clathrin-dependent membrane and protein trafficking core pathophysiological processes in schizophrenia and bipolar disorder?

D. Cotter, J. Prehn, M. Föcking, 2012, Molecular Psychiatry.

Modulation of Mcl-1 sensitizes glioblastoma to TRAIL-induced apoptosis

A. Letai, D. Kögel, J. Prehn, 2013, Apoptosis.

AT-101 simultaneously triggers apoptosis and a cytoprotective type of autophagy irrespective of expression levels and the subcellular localization of Bcl-xL and Bcl-2 in MCF7 cells.

H. Düssmann, D. Kögel, C. Reimertz, 2016, Biochimica et biophysica acta.

Proteasome inhibition can induce an autophagy-dependent apical activation of caspase-8

Maike A. Laussmann, M. Rehm, H. Düssmann, 2011, Cell Death and Differentiation.

Identification of inter- and intra-tumoral molecular phenotypes steering temozolomide resistance in patient-derived glioblastoma cells

D. Lambrechts, M. Lamfers, S. Leenstra, 2023, bioRxiv.

Loss of p53 results in protracted electrographic seizures and development of an aggravated epileptic phenotype following status epilepticus

K. Tanaka, J. Prehn, E. Jimenez-Mateos, 2010, Cell Death and Disease.

Apoptosis induced by proteasome inhibition in cancer cells: predominant role of the p53/PUMA pathway

A. Strasser, D. Kögel, J. Prehn, 2007, Oncogene.

Anti-angiogenic drug scheduling optimisation with application to colorectal cancer

J. Prehn, J. Prehn, M. Sturrock, 2018, Scientific Reports.

Molecular Mechanisms in Amyotrophic Lateral Sclerosis: The Role of Angiogenin, a Secreted RNase

J. Prehn, Isabela M. Aparicio-Erriu, 2012, Front. Neurosci..

Angiogenin protects motoneurons against hypoxic injury

J. Prehn, J. Prehn, Susan F. Fitzpatrick, 2009, Cell Death and Differentiation.

Single-cell imaging of the heat-shock response in colon cancer cells suggests that magnitude and length rather than time of onset determines resistance to apoptosis

H. Düssmann, C. Concannon, T. Bernaś, 2014, Journal of Cell Science.

Platelet‐activating factor antagonists reduce excitotoxic damage in cultured neurons from embryonic chick telencephalon and protect the rat hippocampus and neocortex from ischemic injury in vivo

J. Prehn, J. Prehn, J. Krieglstein, 1993, Journal of neuroscience research.

Active secretion of S100B from astrocytes during metabolic stress

V. Seifert, A. Raabe, D. Kögel, 2006, Neuroscience.

Bcl‐2 homology domain 3‐only proteins Puma and Bim mediate the vulnerability of CA1 hippocampal neurons to proteasome inhibition in vivo

D. Henshall, M. Ward, C. Concannon, 2011, The European journal of neuroscience.

Elevated serum angiogenin levels in ALS

S. Ennis, S. Cronin, O. Hardiman, 2006, Neurology.

Deletion of puma protects hippocampal neurons in a model of severe status epilepticus

K. Tanaka, D. Henshall, J. Prehn, 2010, Neuroscience.