P. Smits

C. Tack, F. Verheugt, P. Smits, 2010, EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology.

Alpha‐receptor blockade improves muscle perfusion and glucose uptake in heart failure

C. Tack, F. Verheugt, P. Smits, 2010, European journal of heart failure.

Short-term glucosamine infusion does not affect insulin sensitivity in humans.

P. Span, C. Tack, P. Smits, 2001, The Journal of clinical endocrinology and metabolism.

Insulin stimulates epinephrine release under euglycemic conditions in humans.

C. Tack, P. Smits, T. Thien, 1998, Metabolism: clinical and experimental.

Nonobese patients with familial combined hyperlipidemia are insulin resistant compared with their nonaffected relatives.

C. Tack, A. Stalenhoef, P. Smits, 1997, Arteriosclerosis, thrombosis, and vascular biology.

Activation of the sodium-potassium pump contributes to insulin-induced vasodilation in humans.

C. Tack, P. Smits, T. Thien, 1996, Hypertension.

Beta2-adrenoceptor stimulation has no effect on skeletal muscle glucose uptake

C. Tack, P. Smits, A. Mulder, 2014, Clinical Autonomic Research.

Regional hyperinsulinemia induces vasodilation but does not modulate adrenergic responsiveness in humans.

C. Tack, P. Smits, T. Thien, 1996, Journal of cardiovascular pharmacology.

Intravenous AICAR administration reduces hepatic glucose output and inhibits whole body lipolysis in type 2 diabetic patients

W. Saris, C. Tack, P. Smits, 2008, Diabetologia.

Vascular adaptation to 4 wk of deconditioning by unilateral lower limb suspension.

M. Hopman, M. Bleeker, P. Smits, 2005, American journal of physiology. Heart and circulatory physiology.

Preserved contribution of nitric oxide to baseline vascular tone in deconditioned human skeletal muscle

M. Hopman, M. Bleeker, P. Smits, 2005, The Journal of physiology.

False-negative dipyridamole-thallium-201 myocardial imaging after caffeine infusion.

F. Wackers, P. Smits, T. Thien, 1991, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

Diuretic efficiency of furosemide during continuous administration versus bolus injection in healthy volunteers

F. Russel, P. Smits, F. Gribnau, 1992, Clinical pharmacology and therapeutics.

The Glu298Asp polymorphism of the NOS 3 gene as a determinant of the baseline production of nitric oxide

P. Doevendans, W. Spiering, A. Kroon, 2002, Journal of hypertension.

Direct vascular effects of furosemide in humans.

A. Hughes, P. Pickkers, F. Russel, 1997, Circulation.

Sympathoinhibitory effect of statins in chronic heart failure

C. Tack, F. Verheugt, J. Lenders, 2009, Clinical Autonomic Research.

Clinical Pharmacokinetics and Efficacy of Renin Inhibitors

J. Lenders, P. Smits, T. Thien, 1995, Clinical pharmacokinetics.

Reduced adenosine receptor stimulation as a pathogenic factor in hyperhomocysteinemia

H. Blom, G. Boers, P. Smits, 2005, Clinical chemistry and laboratory medicine.

The impact of blood pressure measurement methods on the assessment of differences in blood pressure levels between patients with normoalbuminuric type 1 diabetes and healthy controls

P. Smits, T. Thien, J. Lutterman, 1999, Journal of Human Hypertension.

The effect of an advanced glycation end-product crosslink breaker and exercise training on vascular function in older individuals: A randomized factorial design trial

B. Levine, M. Hopman, M. Rikkert, 2013, Experimental Gerontology.

VASOVAGAL SYNCOPE AND SYMPATHETIC ACTIVITY 757

D. Goldstein, P. Smits, T. Thien, 2017 .

Mechanisms of adenosine-induced renal vasodilatation in hypertensive patients

J. V. van Engelshoven, A. Kroon, P. D. de Leeuw, 2005, Journal of hypertension.

Hypoglycaemia downregulates endotoxin-induced production of tumour necrosis factor-α, but does not affect IL-1β, IL-6, or IL-10

M. Netea, J. Meer, P. Smits, 2003 .

Neurohumoral antecedents of vasodepressor reactions

D. Goldstein, P. Smits, T. Thien, 1995, European journal of clinical investigation.

Hemodynamic and humoral effects of coffee after β1‐selective and nonselective β‐blockade

P. Smits, T. Thien, H. Houben, 1983 .

Thiazide-induced vasodilation in humans is mediated by potassium channel activation.

A. Hughes, P. Pickkers, F. Russel, 1998, Hypertension.

Transcapillary escape rate of albumin is increased and related to haemodynamic changes in normo-albuminuric type 1 diabetic patients.

P. Smits, J. Lutterman, G. Vervoort, 1999, Journal of hypertension.

Anti-inflammatory effects of troglitazone in nondiabetic obese subjects independent of changes in insulin sensitivity.

C. Sweep, C. Tack, L. V. van Tits, 2005, The Netherlands journal of medicine.

Real‐Time Contrast Imaging: A New Method to Monitor Capillary Recruitment in Human Forearm Skeletal Muscle

C. Tack, P. Smits, A. V. van Dijk, 2008, Microcirculation.

Effect of the 34C>T variant in the AMPD1 gene on the clinical response to methotrexate in patients with rheumatoid arthritis: comment on the article by Wessels et al.

P. V. van Riel, P. Barrera, P. Smits, 2007, Arthritis and rheumatism.

How systemic inflammation modulates adenosine metabolism and adenosine receptor expression in humans in vivo

J. G. van der Hoeven, P. Pickkers, P. Smits, 2012, Critical care medicine.

Measurement of the endogenous adenosine concentration in humans in vivo: methodological considerations.

P. Pickkers, P. Smits, G. Rongen, 2008, Current drug metabolism.

The effect of adenosine receptor agonists on cytokine release by human mononuclear cells depends on the specific Toll-like receptor subtype used for stimulation.

J. G. van der Hoeven, P. Pickkers, P. Smits, 2006, Cytokine.

In vivo evidence against a role for adenosine in the exercise pressor reflex in humans.

P. Smits, G. Rongen, N. Riksen, 2005, Journal of applied physiology.

Discontinuation of Antihypertensive Medications on the Outcome of Hospitalized Patients With Severe Acute Respiratory Syndrome-Coronavirus 2

P. Smits, S. Simsek, P. D. van der Linden, 2021, Hypertension.

Nicotine enhances the circulatory effects of adenosine in human beings

P. Smits, T. Thien, A. Eijsbouts, 1989, Clinical pharmacology and therapeutics.

Hypothesis: Normalisation of cytokine dysbalance explains the favourable effects of strict glucose regulation in the critically ill.

M. Netea, P. Pickkers, M. Deuren, 2004, The Netherlands journal of medicine.

Effect of Genetic Polymorphisms in UDP-Glucuronosyltransferase 1A6 (UGT1A6) on Acetylsalicylic Acid Metabolism in Healthy Female Volunteers

M. V. van Oijen, M. Janssen, R. Laheij, 2009, Pharmacology.

Are the effects of local treatment with glucocorticoids only local ?

P. Smits, J. V. D. Meer, K. Rahn, 2002 .

Adenosine-induced renal vasodilatation is prolonged in renal artery stenosis.

A. Kroon, P. D. de Leeuw, P. Smits, 1998, Journal of hypertension.

Abstracts of papers

J. Lammers, H. Petri, M. Danhof, 1966, Journal of Symbolic Logic.

Atorvastatin does not affect ischaemia-induced phosphatidylserine exposition in humans in-vivo.

W. Oyen, C. Janssen, O. Boerman, 2012, Journal of atherosclerosis and thrombosis.

Short-term Statin Treatment Does Not Prevent Ischemia and Reperfusion-induced Endothelial Dysfunction in Humans

P. Smits, K. Wever, G. Rongen, 2012, Journal of cardiovascular pharmacology.

Role of potassium channels in the modulation of insulin release

P. Smits, 1996, Diabetologia.

Effects of sulfonylurea derivatives on ischemia-induced loss of function in the isolated rat heart.

B. Oeseburg, P. Smits, R. J. Legtenberg, 2001, European journal of pharmacology.

Reduced plasma total homocysteine concentrations in Type 1 diabetes mellitus is determined by increased renal clearance

P. Smits, H. Blom, G. Vervoort, 2005, Diabetic medicine : a journal of the British Diabetic Association.

Hemodynamic changes caused by glibenclamide in isolated, working, erythrocyte perfused rat heart.

B. Oeseburg, P. Smits, R. J. Legtenberg, 1999, Advances in experimental medicine and biology.

Blockade of vascular ATP-sensitive potassium channels reduces the vasodilator response to ischaemia in humans

F. Russel, P. Smits, T. Thien, 1996, Diabetologia.

Effect of Long‐Term Angiotensin‐Converting Enzyme Inhibition on Endothelial Function in Patients with the Insulin‐Resistance Syndrome

P. Smits, J. Lutterman, T. Thien, 1995, Journal of cardiovascular pharmacology.

Evidence for an Antagonism Between Caffeine and Adenosine in the Human Cardiovascular System

P. Smits, T. Thien, R. D. Abreu, 1987, Journal of cardiovascular pharmacology.

Salvia Miltiorrhiza Root Water-Extract (Danshen) Has No Beneficial Effect on Cardiovascular Risk Factors. A Randomized Double-Blind Cross-Over Trial

C. Tack, R. Donders, F. Russel, 2015, PloS one.

capillariesefflux pumps in isolated fish brain

F. Russel, K. Choe, P. Smits, 2013 .

Effect of chronic smoking on endothelium-dependent vascular relaxation in humans.

P. Smits, T. Thien, J. Lenders, 1993, Clinical science.

Glomerular hyperfiltration in type 1 diabetes mellitus results from primary changes in proximal tubular sodium handling without changes in volume expansion

P. Smits, J. Berden, G. Vervoort, 2005, European journal of clinical investigation.

The role of 11β-hydroxysteroid dehydrogenase in the pathogenesis of hypertension

S. Van Uum, J. Lenders, P. Smits, 1998 .

Vascular effects of loop diuretics.

P. Pickkers, F. Russel, P. Smits, 1996, Cardiovascular research.

Review Vascular effects of loop diuretics

P. Pickkers, P. Smits, 1996 .

No specific effect of fluoxetine treatment on fasting glucose, insulin, lipid levels, and blood pressure in healthy men with abdominal obesity.

M. Visser, J. Seidell, P. Smits, 1994, Obesity research.

Intravenous AICAR During Hyperinsulinemia Induces Systemic Hemodynamic Changes but Has No Local Metabolic Effect

C. Tack, P. Smits, M. Bosselaar, 2011, Journal of clinical pharmacology.

Rapid vascular adaptations to training and detraining in persons with spinal cord injury.

M. Hopman, P. Smits, D. Thijssen, 2006, Archives of physical medicine and rehabilitation.

Preserved &agr;-Adrenergic Tone in the Leg Vascular Bed of Spinal Cord–Injured Individuals

M. Hopman, P. Smits, G. Rongen, 2003, Circulation.

ATP‐induced vasodilation in human skeletal muscle

P. Smits, G. Rongen, N. Verkaik, 2004, British journal of pharmacology.

Vascular Effects of Metabolic Inhibition by 2-Deoxy-D-Glucose in Humans

C. Tack, P. Smits, E. Abbink, 2001, Journal of cardiovascular pharmacology.

Preserved vasodilator response to adenosine in insulin‐dependent diabetes mellitus

P. Smits, T. Thien, G. Rongen, 1996, European journal of clinical investigation.

Sodium–lithium countertransport is increased in normoalbuminuric type 1 diabetes but is not related to other risk factors for microangiopathy

J. Wetzels, P. Smits, J. De Pont, 2002, European journal of clinical investigation.

Vascular and metabolic effects of the haem oxygenase-1 inducer haem arginate in subjects with the metabolic syndrome: A translational cross-over study

P. Smits, W. Peters, F. Wagener, 2016, Diabetes & vascular disease research.

The nonspecific anti-inflammatory therapy with methotrexate for patients with chronic heart failure.

P. Smits, G. Rongen, N. Riksen, 2006, American heart journal.

Atrial natriuretic peptide increases albuminuria in type 1 diabetic patients: evidence for blockade of tubular protein reabsorption.

J. Wetzels, P. Smits, I. Klasen, 1999, European journal of clinical investigation.

Impaired Vasodilator Response to Atrial Natriuretic Factor in IDDM

P. Smits, T. Thien, J. Lutterman, 1993, Diabetes.

Intra-arterial AICA-riboside administration induces NO-dependent vasodilation in vivo in human skeletal muscle.

L. V. van Loon, C. Tack, P. Smits, 2009, American journal of physiology. Endocrinology and metabolism.

Response to Howard and Howard

C. Tack, P. Demacker, A. Stalenhoef, 1998, Diabetes Care.

Preserved Response to Diuretics in Rosiglitazone‐Treated Subjects With Insulin Resistance: A Randomized Double‐Blind Placebo‐Controlled Crossover Study

P. Smits, R. Masereeuw, P. Deen, 2011, Clinical pharmacology and therapeutics.

Autonomic neuropathy predisposes to rosiglitazone-induced vascular leakage in insulin-treated patients with type 2 diabetes: a randomised, controlled trial on thiazolidinedione-induced vascular leakage

C. Tack, P. Smits, M. Stewart, 2010, Diabetologia.

Vascular K(ATP) channel blockade by glibenclamide, but not by acarbose, in patients with Type II diabetes.

C. Tack, P. Pickkers, F. Russel, 2002, Clinical science.

Vascular KATP channel blockade by glibenclamide , but not by acarbose , in patients with Type II diabetes

C. Tack, P. Pickkers, F. Russel, 2022 .

Calcitonin gene–related peptide: Exploring its vasodilating mechanism of action in humans

H. Struijker‐Boudier, L. V. Van Bortel, P. Pickkers, 2003, Clinical pharmacology and therapeutics.

Forearm Resistance Vessels Induced Vasodilation Is Dependent On Hyperpolarization in − C-Type Natriuretic Peptide

P. Smits, J. Burnett, P. Morrison, 2001 .

No role of calcium‐ and ATP‐dependent potassium channels in insulin‐induced vasodilation in humans in vivo

C. Tack, P. Smits, E. Abbink, 2002, Diabetes/metabolism research and reviews.

Elevated skeletal muscle blood flow in noncomplicated type 1 diabetes mellitus: role of nitric oxide and sympathetic tone.

P. Smits, J. Lutterman, G. Vervoort, 1999, Hypertension.

Pharmacodynamics of L-NMMA in Type 1 Diabetes Patients and Control Subjects

P. Smits, B. Veldman, M. Waanders, 2004, Journal of cardiovascular pharmacology.

NG-Monomethyl-l-ARG Reduces the Forearm Vasodilator Response to Acetylcholine but Not to Methacholine in Humans

P. Smits, T. Thien, G. Rongen, 1993, Journal of cardiovascular pharmacology.

The Bilirubin-Increasing Drug Atazanavir Improves Endothelial Function in Patients With Type 2 Diabetes Mellitus

P. Smits, F. Wagener, D. Dekker, 2011, Arteriosclerosis, thrombosis, and vascular biology.

The effect of antecedent hypoglycaemia on β2-adrenergic sensitivity in healthy participants with the Arg16Gly polymorphism of the β2-adrenergic receptor

C. Tack, P. Smits, B. D. de Galan, 2011, Diabetologia.

Plasma metanephrine levels are decreased in type 1 diabetic patients with a severely impaired epinephrine response to hypoglycemia, indicating reduced adrenomedullary stores of epinephrine.

C. Sweep, C. Tack, J. Lenders, 2004, The Journal of clinical endocrinology and metabolism.

Antecedent adrenaline attenuates the responsiveness to but not the release of counterregulatory hormones during subsequent hypoglycemia.

C. Sweep, C. Tack, J. Lenders, 2003, The Journal of clinical endocrinology and metabolism.

Enhanced endothelin-1-mediated leg vascular tone in healthy older subjects.

M. Hopman, P. Smits, G. Rongen, 2007, Journal of applied physiology.

Presence and mechanism of direct vascular effects of amiloride in humans.

A. Hughes, P. Pickkers, F. Russel, 1999, Journal of cardiovascular pharmacology.

Rosiglitazone reduces ischaemia-reperfusion injury in patients with the metabolic syndrome.

W. Oyen, C. Tack, O. Boerman, 2010, European heart journal.

Does it matter whether blood pressure measurements are taken with subjects sitting or supine?

R. Netea, J. Lenders, P. Smits, 1998, Journal of hypertension.

The role of adenosine in insulin-induced vasodilation.

C. Tack, P. Smits, J. Lutterman, 1999, Journal of cardiovascular pharmacology.

The effect of fluoxetine on body weight, body composition and visceral fat accumulation.

M. Visser, J. Seidell, P. Smits, 1993, International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity.

Short-term glucosamine infusion does not affect insulin sensitivity in humans.

P. Span, C. Tack, P. Smits, 2001, The Journal of clinical endocrinology and metabolism.

Local vasoconstriction in spinal cord-injured and able-bodied individuals.

M. Hopman, P. Smits, G. Rongen, 2007, Journal of applied physiology.

Diuretic efficacy of high dose furosemide in severe heart failure: bolus injection versus continuous infusion.

F. Russel, P. Smits, T. Dormans, 1996, Journal of the American College of Cardiology.

Atrial natriuretic peptide-induced microalbuminuria is associated with endothelial dysfunction in noncomplicated type 1 diabetes patients.

J. Wetzels, B. Bravenboer, P. Smits, 2002, American journal of kidney diseases : the official journal of the National Kidney Foundation.

Angiotensin II Type 1 Receptor Blockade Does Not Enhance Apoptotic Cell Death During Ischemia and Reperfusion in Humans In Vivo

W. Oyen, O. Boerman, G. Scheffer, 2011, Journal of cardiovascular pharmacology.

Possibility of downregulation of atrial natriuretic peptide receptor coupled to guanylate cyclase in peripheral vascular beds of patients with chronic severe heart failure.

P. Smits, T. Thien, T. Jansen, 1993, Circulation.

Stress Susceptibility as a Determinant of the Response to Adrenergic Stimuli in Mesenteric Resistance Arteries of the Rat

A. Cools, B. Ellenbroek, F. Russel, 2002, Journal of cardiovascular pharmacology.

Nitric oxide-mediated vascular tone in the fetal placental circulation of patients with type 1 diabetes mellitus.

E. Steegers, F. Russel, P. Smits, 2003, Placenta.

Improving Myocardial Perfusion by Percutaneous Coronary Intervention Reduces Central Sympathetic Activity in Stable Angina

C. Tack, F. Verheugt, J. Lenders, 2010, Clinical cardiology.

Influence of angiotensin converting enzyme inhibition and angiotensin II type 1 receptor antagonism on renal sodium and water handling and albuminuria during infusion of atrial natriuretic factor into healthy volunteers

J. Wetzels, P. Smits, G. Vervoort, 1998, Journal of hypertension.

Summary: Flosequinan (BTS 49465, 7-fluoro-1-methyl-3-methyl-

P. Smits, T. Thien, M. Janssen, 1995 .

Presynaptic inhibition of norepinephrine release from sympathetic nerve endings by endogenous adenosine.

P. Smits, T. Thien, J. Lenders, 1996, Hypertension.

Probenecid interferes with renal oxidative metabolism: A potential pitfall in its use as an inhibitor of drug transport

F. Russel, P. Willems, P. Smits, 2000, British journal of pharmacology.

Boiled Coffee and Blood Pressure A 14-Week Controlled Trial

M. Katan, J. Lenders, P. Smits, 1991, Hypertension.

The cardiovascular effects of regular and decaffeinated coffee.

P. Smits, T. Thien, A. van 't Laar, 1985, British journal of clinical pharmacology.

Involvement of guanylyl cyclase and cGMP in the regulation of Mrp2-mediated transport in the proximal tubule.

F. Russel, P. Smits, R. Masereeuw, 2004, American journal of physiology. Renal physiology.

Effects of coffee on cardiovascular responses to stress: a 14‐week controlled trial.

M. Katan, P. Smits, T. Thien, 1992, Psychosomatic medicine.

Physical (in)activity and endothelium‐derived constricting factors: overlooked adaptations

D. Thijssen, M. Hopman, P. Smits, 2008, The Journal of physiology.

Adenosine induces renal vasodilation in primary hypertensive patients.

P. D. de Leeuw, P. Smits, T. Thien, 1991, Journal of hypertension. Supplement : official journal of the International Society of Hypertension.

Only weak vasorelaxant properties of loop diuretics in isolated resistance arteries from man, rat and guinea pig.

A. Hughes, P. Pickkers, F. Russel, 2003, European journal of pharmacology.

Effect of Sex on the Cardiovascular Response to Adrenaline in Humans

P. Smits, B. D. de Galan, B. Schouwenberg, 2006, Journal of cardiovascular pharmacology.

Impaired KATP channel function in the fetoplacental circulation of patients with type 1 diabetes mellitus.

J. A. van der Laak, E. Steegers, F. Russel, 2005, American journal of obstetrics and gynecology.

Verapamil causes decreased diaphragm endurance but no decrease of nocturnal O2 saturation in patients with chronic obstructive pulmonary disease

H. Folgering, M. Broeders, P. Smits, 2000, European Journal of Clinical Pharmacology.

VASCULAR ENDOTHELIAL GROWTH FACTOR IS INCREASED DURING THE FIRST 48 HOURS OF HUMAN SEPTIC SHOCK AND CORRELATES WITH VASCULAR PERMEABILITY

P. Pickkers, M. Deuren, T. Sprong, 2005, Shock.

Upregulation of Ecto-5′-Nucleotidase by Rosuvastatin Increases the Vasodilator Response to Ischemia

G. Scheffer, P. Smits, M. de Rooij, 2010, Hypertension.

Coronary heart disease Augmented hyperaemia and reduced tissue injury in response to ischaemia in subjects with the 34 C > T variant of the AMPD 1 gene

W. Oyen, G. Borm, O. Boerman, 2017 .

Augmented hyperaemia and reduced tissue injury in response to ischaemia in subjects with the 34C > T variant of the AMPD1 gene.

W. Oyen, G. Borm, O. Boerman, 2007, European heart journal.

A comparison of 5 days of dirithromycin and 7 days of clarithromycin in acute bacterial exacerbation of chronic bronchitis.

P. Smits, J. Hosie, G. Sides, 1995, The Journal of antimicrobial chemotherapy.

Effects of adenosine on human coronary arterial circulation.

P. Smits, T. Thien, 1991, Circulation.

Ischaemic preconditioning: from molecular characterisation to clinical application--part II.

P. Smits, G. Rongen, N. Riksen, 2004, The Netherlands journal of medicine.

Parenteral bilirubin in healthy volunteers: a reintroduction in translational research

P. Pickkers, F. Russel, P. Smits, 2018, British journal of clinical pharmacology.

Interaction of sulphonylurea derivatives with vascular ATP-sensitive potassium channels in humans

F. Russel, P. Smits, T. Thien, 1996, Diabetologia.

Effects of tolbutamide on vascular ATP-sensitive potassium channels in humans. Comparison with literature data on glibenclamide and glimepiride.

F. Russel, P. Smits, T. Thien, 1996, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

The 1976C>T polymorphism in the adenosine A2A receptor gene does not affect the vasodilator response to adenosine in humans in vivo

B. Franke, P. Smits, G. Rongen, 2007, Pharmacogenetics & Genomics.

Enhanced Cellular Adenosine Uptake Limits Adenosine Receptor Stimulation in Patients With Hyperhomocysteinemia

H. Blom, G. Boers, P. Smits, 2004, Arteriosclerosis, thrombosis, and vascular biology.

Abstracts of papers clinical pharmacological meeting

D. J. Veldhuisen, J. Remon, J. Ottervanger, 2005, Pharmacy World and Science.

Endothelium-dependent vasodilation in hypercholesterolaemic subjects

G. Watts, J. Ritter, P. Chowienczyk, 1993, The Lancet.

Microvascular permeability during experimental human endotoxemia: an open intervention study

J. G. van der Hoeven, P. Pickkers, P. Smits, 2005 .

Attenuated Forearm Vasodilator Response to Atrial Natriuretic Factor in the Elderly

P. Smits, T. Thien, T. Thien, 1991, Hypertension.

TNFα AND IL-1β EXERT NO DIRECT VASOACTIVITY IN HUMAN ISOLATED RESISTANCE ARTERIES

M. Netea, J. Meer, P. Pickkers, 2002 .

The role of the α‐adrenergic receptor in the leg vasoconstrictor response to orthostatic stress

M. Hopman, P. Smits, G. Rongen, 2009, Acta physiologica.

Comparison of two indices for forearm noradrenaline release in humans.

J. Floras, P. Smits, J. Lenders, 2000, Clinical science.

The Arg16Gly variant of the &bgr;2-adrenergic receptor predisposes to hypoglycemia unawareness in type 1 diabetes mellitus

B. Franke, W. Spiering, M. Coenen, 2008, Pharmacogenetics and genomics.

Differential effects of low- and high-intensity lower body negative pressure on noradrenaline and adrenaline kinetics in humans.

D. Goldstein, P. Smits, T. Thien, 1996, Clinical science.

Effect of troglitazone on lipoprotein(a) levels in obese subjects.

C. Tack, P. Demacker, A. Stalenhoef, 1999, Diabetes care.

Cardiovascular effects of sulphonylurea derivatives

P. Smits, 1997, Diabetologia.

Activation of ATP-sensitive potassium channels contributes to reactive hyperemia in humans.

P. Ganz, M. Creager, P. Smits, 1996, The American journal of physiology.

Cardiovascular effects of sulphonylurea derivatives. Implications for the treatment of NIDDM?

P. Smits, T. Thien, 1995, Diabetologia.

ACTIVATION OF THE ATP-DEPENDENT POTASSIUM CHANNEL ATTENUATES NOREPINEPHRINE-INDUCED VASOCONSTRICTION IN THE HUMAN FOREARM

J. G. van der Hoeven, P. Pickkers, P. Smits, 2004, Shock.

The role of myocardial KATP-channel blockade in the protective effects of glibenclamide against ischaemia in the rat heart.

B. Oeseburg, P. Smits, G. Rongen, 2002, Pharmacology & toxicology.

Glibenclamide attenuates ischemia-induced acidosis and loss of cardiac function in rats.

A. Heerschap, B. Oeseburg, P. Smits, 2002, European journal of pharmacology.

Hemodynamic effects of atrial natriuretic factor in young and elderly subjects

T. Benraad, P. Smits, T. Thien, 1990, Clinical pharmacology and therapeutics.

N-acetylcysteine restores nitric oxide-mediated effects in the fetoplacental circulation of preeclamptic patients.

E. Steegers, P. Smits, W. Peters, 2004, American journal of obstetrics and gynecology.

Effects of allopregnanolone on sedation in men, and in women on oral contraceptives

J. Buitelaar, E. Luijtelaar, R. Verkes, 2007, Psychoneuroendocrinology.

The dipeptidyl peptidase-4 inhibitor vildagliptin does not affect ex vivo cytokine response and lymphocyte function in patients with type 2 diabetes mellitus.

M. Netea, C. Tack, M. Gresnigt, 2014, Diabetes research and clinical practice.

trial. Effect of decaffeinated versus regular coffee on blood pressure. A 12-week, double-blind

M. Katan, P. Smits, T. Thien, 2013 .

double-blind trial Effect of decaffeinated versus regular coffee on blood pressure. A 12- week,

M. Katan, P. Smits, T. Thien, 2011 .

Influence of slow calcium-channel blockade on the cardiovascular effects of coffee

P. Smits, T. Thien, A. Laar, 2004, European Journal of Clinical Pharmacology.

The role of epinephrine in the circulatory effects of coffee

P. Smits, T. Thien, G. Pieters, 1986, Clinical pharmacology and therapeutics.

Circulatory effects of coffee in relation to the pharmacokinetics of caffeine.

P. Smits, T. Thien, A. van't Laar, 1985, The American journal of cardiology.

Unilateral lower limb suspension can cause deep venous thrombosis.

M. Hopman, M. Bleeker, P. Smits, 2004, American journal of physiology. Regulatory, integrative and comparative physiology.

Acute intrarenal administration of cortisol has no effect on renal blood flow in hypertensive individuals

C. Sweep, B. Walker, A. Kroon, 2002, Journal of hypertension.

Metformin improves cardiac functional recovery after ischemia in rats.

B. Oeseburg, P. Smits, R. J. Legtenberg, 2002, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

The effect of α‐human atrial natriuretic peptide on the incidence of acute renal failure in cadaveric kidney transplantation

A. Hoitsma, P. Smits, F. Huysmans, 1989, Transplant international : official journal of the European Society for Organ Transplantation.

Dysfunction of the cyclo‐oxygenase pathway in the foetoplacental circulation in Type 1 diabetes mellitus

E. Steegers, F. Russel, P. Smits, 2005, Diabetic medicine : a journal of the British Diabetic Association.

Flow ratios to express results obtained with the human in vivo 'perfused forearm technique'.

P. Smits, G. Rongen, G. Lambrou, 2005, British journal of clinical pharmacology.

Dose‐dependent inhibition of the hemodynamic response to dipyridamole by caffeine

P. Smits, T. Thien, E. Pijpers, 1991, Clinical pharmacology and therapeutics.

Inhibition of carbonic anhydrase accounts for the direct vascular effects of hydrochlorothiazide.

A. Hughes, P. Pickkers, P. Smits, 1999, Hypertension.

Impaired effect of relaxin on vasoconstrictor reactivity in spontaneous hypertensive rats

P. Smits, Jonathan H. Gooi, J. Drongelen, 2013, Peptides.

Impaired vascular responses to relaxin in diet-induced overweight female rats.

F. Sweep, L. Parry, P. Smits, 2012, Journal of applied physiology.

Aging attenuates the vasodilator response to relaxin.

F. Sweep, P. Smits, Jonathan H. Gooi, 2011, American journal of physiology. Heart and circulatory physiology.

Effect of atrial natriuretic factor on skin microcirculation versus skeletal muscle blood flow.

H. Wollersheim, P. Smits, T. Thien, 1996, Journal of cardiovascular pharmacology.

Glibenclamide depletes ATP in renal proximal tubular cells by interfering with mitochondrial metabolism

F. Russel, P. Smits, R. Masereeuw, 2005, British journal of pharmacology.

Sulphonylurea drugs reduce hypoxic damage in the isolated perfused rat kidney

F. Russel, P. Smits, H. Dijkman, 2000, British journal of pharmacology.

renal proximal tubule Role of NO in endothelin-regulated drug transport in the

F. Russel, P. Smits, David S. Miller, 2016 .

Role of NO in endothelin-regulated drug transport in the renal proximal tubule.

F. Russel, P. Smits, R. Masereeuw, 2002, American journal of physiology. Renal physiology.

Hemodynamic and humoral effects of coffee after beta 1-selective and nonselective beta-blockade.

P. Smits, T. Thien, A. van't Laar, 1983, Clinical pharmacology and therapeutics.

Nitric oxide and potassium channels are involved in brain natriuretic peptide induced vasodilatation in man

A. Kroon, P. D. de Leeuw, P. Smits, 2002, Journal of hypertension.

Role of the wrist cuff in forearm plethysmography.

P. Smits, T. Thien, J. Lenders, 1991, Clinical science.

The case for case reports in the Netherlands Journal of Medicine.

J. Drenth, A. Stalenhoef, P. Smits, 2006, The Netherlands journal of medicine.

Dipyridamole enhances ischaemia‐induced reactive hyperaemia by increased adenosine receptor stimulation

G. Scheffer, P. Smits, G. Rongen, 2008, British journal of pharmacology.

Diadenosine pentaphosphate vasodilates the forearm vascular bed: Inhibition by theophylline and augmentation by dipyridamole

F. Russel, P. Smits, G. Rongen, 2002, Clinical pharmacology and therapeutics.

Hydrochlorothiazide exerts no direct vasoactivity in the human forearm

P. Pickkers, P. Smits, T. Thien, 1995, Journal of hypertension.

Long-Term ßr Adrenergic Blockade Restores Adrenomedullary Activity in Primary Hypertension

C. Tack, P. Smits, T. Thien, 2017 .

Long-term beta 1-adrenergic blockade restores adrenomedullary activity in primary hypertension.

C. Tack, P. Smits, T. Thien, 1997, Journal of cardiovascular pharmacology.

Glomerular filtration and saturable absorption of iohexol in the rat isolated perfused kidney

F. Russel, P. Smits, R. Masereeuw, 1996, British journal of pharmacology.

overweight female rats Impaired vascular responses to relaxin in diet-induced

F. Sweep, C. Leo, H. Parkington, 2015 .

Iso-osmolar prehydration shifts the cytokine response towards a more anti-inflammatory balance in human endotoxemia

M. Netea, J. G. van der Hoeven, P. Pickkers, 2005, Journal of endotoxin research.

Combination Diuretic Therapy in Severe Congestive Heart Failure

F. Russel, P. Smits, T. Dormans, 1998, Drugs.

Insulin-induced vasodilatation and endothelial function in obesity/insulin resistance. Effects of troglitazone

C. Tack, P. Smits, J. Lutterman, 1998, Diabetologia.

Haemodynamic actions of insulin

D. Goldstein, J. Lenders, P. Smits, 1998, Current opinion in nephrology and hypertension.

Arm position is important for blood pressure measurement

P. Smits, T. Thien, J. Lenders, 1999, Journal of Human Hypertension.

Tissue distribution Juxtaglomerular cells Sympathetic efferent nerves Sympathetic afferent nerves Smooth muscle cells in glomerular afferent arterioles and possibly in pulmonary vascular bed Cardiac conduction system Cardiomyocytes Vascular smooth muscle cells

J. Floras, P. Smits, T. Thien, 2017 .

Characterization of ATP-induced vasodilation in the human forearm vascular bed.

P. Smits, T. Thien, G. Rongen, 1994, Circulation.

Nifedipine vs Placebo for Treatment of Chronic Chilblains: A Randomized Controlled Trial

P. Smits, A. Lagro-Janssen, J. Bor, 2016, The Annals of Family Medicine.

Short-Term Exposure of Renal Proximal Tubules to Gentamicin Increases Long-Term Multidrug Resistance Protein 2 (Abcc2) Transport Function and Reduces Nephrotoxicant Sensitivity

F. Russel, P. Smits, R. Masereeuw, 2005, Journal of Pharmacology and Experimental Therapeutics.

Adrenergic receptor stimulation attenuates insulin-stimulated glucose uptake in 3T3-L1 adipocytes by inhibiting GLUT4 translocation.

F. Sweep, C. Tack, P. Smits, 2005, American journal of physiology. Endocrinology and metabolism.

The cardiovascular effects of methylxanthines.

P. Smits, G. Rongen, N. Riksen, 2011, Handbook of experimental pharmacology.

Upregulation of renal inducible nitric oxide synthase during human endotoxemia and sepsis is associated with proximal tubule injury.

J. G. van der Hoeven, P. Pickkers, F. Russel, 2006, Clinical journal of the American Society of Nephrology : CJASN.

Haematopoietic stem cells and endothelial progenitor cells in healthy men: effect of aging and training

F. Sweep, M. Hopman, A. V. van Zonneveld, 2006, Aging cell.

Influence of the arm position on intra-arterial blood pressure measurement

P. Smits, T. Thien, J. Lenders, 1998, Journal of Human Hypertension.

Effect of different sympathetic stimuli-autonomic dysreflexia and head-up tilt-on leg vascular resistance in spinal cord injury.

A. Geurts, M. Hopman, P. Smits, 2010, Archives of physical medicine and rehabilitation.

ffect of Different Sympathetic Stimuli – Autonomic Dysreflexia nd Head-up Tilt – on Leg Vascular Resistance in pinal Cord Injury

A. Geurts, P. Smits, G. Rongen, 2010 .

In Vivo Evidence for Nitric Oxide–Mediated Calcium-Activated Potassium-Channel Activation During Human Endotoxemia

J. G. van der Hoeven, P. Pickkers, P. Smits, 2006, Circulation.

Sympathetic Nonadrenergic Transmission Contributes to Autonomic Dysreflexia in Spinal Cord–Injured Individuals

A. Geurts, M. Hopman, P. Pickkers, 2010, Hypertension.

Angiotensin II contributes to the increased baseline leg vascular resistance in spinal cord-injured individuals

A. Geurts, M. Hopman, P. Smits, 2010, Journal of hypertension.

The Influence of Diazepam and Midazolam on Adenosine-Induced Forearm Vasodilation in Humans

P. Smits, G. Rongen, E. V. van Ginneken, 2004, Journal of cardiovascular pharmacology.

Dipyridamole augments the antiinflammatory response during human endotoxemia

J. G. van der Hoeven, P. Pickkers, P. Smits, 2011, Critical care.

Gender differences in the innate immune response and vascular reactivity following the administration of endotoxin to human volunteers*

M. Netea, J. G. van der Hoeven, P. Pickkers, 2007, Critical care medicine.

Role of potassium channel blockade in the treatment of sepsis-induced vascular hyporeactivity.

P. Pickkers, P. Smits, H. van der Hoeven, 2006, Critical care medicine.

TNFalpha and IL-1beta exert no direct vasoactivity in human isolated resistance arteries.

M. Netea, J. V. D. van der Meer, P. Pickkers, 2002, Cytokine.

Potential role for adenosine in the pathogenesis of the vascular complications of hyperhomocysteinemia.

H. Blom, G. Boers, F. Russel, 2003, Cardiovascular research.

Stress Susceptibility As a Determinant of Endothelium-dependent Vascular Reactivity in Rat Mesenteric Arteries

A. Cools, B. Ellenbroek, F. Russel, 2003, Journal of cardiovascular pharmacology.

Caffeine and theophylline attenuate adenosine‐induced vasodilation in humans

J. Lenders, P. Smits, T. Thien, 1990, Clinical pharmacology and therapeutics.

Caffeine prevents protection in two human models of ischemic preconditioning.

W. Oyen, O. Boerman, P. Smits, 2006, Journal of the American College of Cardiology.

Absorption of High Dose Furosemide (Frusemide) in Congestive Heart Failure

F. Russel, P. Smits, F. Gribnau, 1992, Clinical pharmacokinetics.

[Lavage almost never indicated after an autointoxication].

F. Russel, P. Smits, C. Kramers, 2000, Nederlands tijdschrift voor geneeskunde.

The Netherlands Journal of Medicine's hit list: best cited articles in 2003.

J. Drenth, A. Stalenhoef, P. Smits, 2005, The Netherlands journal of medicine.

Abstracts of papers

Eck, J. Neijt, J. Nortier, 2005, Pharmaceutisch Weekblad.

Endothelium-Dependent Vascular Relaxation in Patients With Type I Diabetes

P. Smits, J. Lutterman, M. Jacobs, 1993, Diabetes.

Acute elevation of plasma non-esterified fatty acids increases pulse wave velocity and induces peripheral vasodilation in humans in vivo.

R. Heine, S. Bakker, C. Tack, 2007, Clinical science.

Endothelial release of nitric oxide contributes to the vasodilator effect of adenosine in humans.

M. Creager, D. Lipson, P. Smits, 1995, Circulation.

Repeated ischaemic isometric exercise increases muscle fibre conduction velocity in humans: involvement of Na+‐K+‐ATPase

D. Stegeman, M. Zwarts, J. P. Dijk, 2002, The Journal of physiology.

Excretion and accumulation of diatrizoate in the isolated perfused rat kidney

F. Russel, P. Smits, R. Masereeuw, 1997 .

Leg blood flow measurements using venous occlusion plethysmography during head-up tilt

M. Hopman, P. Smits, G. Rongen, 2007, Clinical Autonomic Research.

Caffeine can decrease insulin sensitivity in humans.

C. Tack, G. Keijzers, P. Smits, 2002, Diabetes care.

Acute and long-term cardiovascular effects of coffee: implications for coronary heart disease.

P. Smits, G. Rongen, N. Riksen, 2009, Pharmacology & therapeutics.

Human in vivo research on the vascular effects of adenosine.

D. Yellon, P. Smits, G. Rongen, 2008, European journal of pharmacology.

Reproducibility of skin microcirculatory measurements in humans, with special emphasis on capillaroscopy

H. Wollersheim, P. Smits, E. Abbink, 2001, Vascular medicine.

Sympathoinhibition by atorvastatin in hypertensive patients.

C. Tack, F. Verheugt, J. Lenders, 2010, Circulation journal : official journal of the Japanese Circulation Society.

Preserved sensitivity to beta2-adrenergic receptor agonists in patients with type 1 diabetes mellitus and hypoglycemia unawareness.

P. Smits, B. D. de Galan, L. Wennekes, 2006, The Journal of clinical endocrinology and metabolism.

Theophylline improves hypoglycemia unawareness in type 1 diabetes.

J. Pasman, C. Tack, F. Russel, 2002, Diabetes.

Effect of Decaffeinated Versus Regular Coffee on Blood Pressure A 12‐Week, Double‐Blind Trial

M. Katan, P. Smits, T. Thien, 1989, Hypertension.

Endothelium-dependent and -independent vasodilation of the superficial femoral artery in spinal cord-injured subjects.

D. Green, M. Hopman, M. Bleeker, 2008, Journal of applied physiology.

Vascular adaptation to deconditioning and the effect of an exercise countermeasure: results of the Berlin Bed Rest study.

Dieter Felsenberg, Jörn Rittweger, D. Felsenberg, 2005, Journal of applied physiology.

Vascular adaptations to 8‐week cycling training in older men

P. Smits, D. Thijssen, D. Thijssen, 2007, Acta physiologica.

Sympathetic nervous system contributes to the age-related impairment of flow-mediated dilation of the superficial femoral artery.

M. Hopman, P. Smits, D. Thijssen, 2006, American journal of physiology. Heart and circulatory physiology.

Vildagliptin Improves Endothelium-Dependent Vasodilatation in Type 2 Diabetes

M. Netea, C. Tack, P. Smits, 2011, Diabetes Care.

Methotrexate modulates the kinetics of adenosine in humans in vivo

P. van Riel, P. Barrera, P. Smits, 2005, Annals of the rheumatic diseases.

Association of Fitness Level With Cardiovascular Risk and Vascular Function in Older Nonexercising Individuals.

M. O. Olde Rikkert, M. Hopman, P. Smits, 2015, Journal of Aging and Physical Activity.

The effect of acute exercise on glycogen synthesis rate in obese subjects studied by 13C MRS

M. van der Graaf, A. Heerschap, C. Tack, 2010, European Journal of Applied Physiology.

Fluid retention and vascular effects of rosiglitazone in obese, insulin-resistant, nondiabetic subjects.

C. Tack, P. Smits, M. Stewart, 2006, Diabetes care.

Pathophysiology and management of recurrent hypoglycaemia and hypoglycaemia unawareness in diabetes.

C. Tack, P. Smits, B. D. de Galan, 2006, The Netherlands journal of medicine.

Metformin Prevents Myocardial Reperfusion Injury by Activating the Adenosine Receptor

M. Mocanu, D. Yellon, S. Davidson, 2009, Journal of cardiovascular pharmacology.

High dose ascorbic acid does not reverse central sympathetic overactivity in chronic heart failure

C. Tack, F. Verheugt, J. Lenders, 2011, Journal of clinical pharmacy and therapeutics.

Effect of glycyrrhetinic acid on 11 beta-hydroxysteroid dehydrogenase activity in normotensive and hypertensive subjects.

C. Sweep, B. Walker, P. D. de Leeuw, 2002, Clinical science.

Role of Endogenous Vascular Endothelial Growth Factor in Endothelium-Dependent Vasodilation in Humans

F. Sweep, A. Geurts-Moespot, C. V. van Herpen, 2013, Hypertension.

Functional Vascular Changes of the Kidney during Pregnancy in Animals: A Systematic Review and Meta-Analysis

P. Smits, R. D. de Vries, F. Lotgering, 2014, PloS one.

Adaptive changes of mesenteric arteries in pregnancy: a meta-analysis.

P. Smits, C. Hooijmans, F. Lotgering, 2012, American journal of physiology. Heart and circulatory physiology.

Reproducibility of the blood pressure fall at night in healthy normotensive volunteers.

P. Smits, T. Thien, J. Lenders, 1991, Journal of hypertension. Supplement : official journal of the International Society of Hypertension.

Forearm vasoconstrictor response in uncomplicated type 1 diabetes mellitus

P. Smits, J. Willemsen, H. Ross, 2006, European journal of clinical investigation.

Life-threatening hypokalaemia and lactate accumulation after autointoxication with Stacker 2, a 'powerful slimming agent'.

P. Smits, B. Koch, A. Bartelink, 2008, British journal of clinical pharmacology.

Contribution of different local vascular responses to mid-gestational vasodilation.

F. Sweep, P. Smits, F. Lotgering, 2011, American journal of obstetrics and gynecology.

Modulation of Innate Immunity by Adenosine Receptor Stimulation

J. G. van der Hoeven, P. Pickkers, P. Smits, 2011, Shock.

Long-term effect of inhibition of the angiotensin-converting enzyme (ACE) on cavernosal perfusion in men with atherosclerotic erectile dysfunction: a pilot study.

L. Kiemeney, P. Smits, T. Thien, 2005, The journal of sexual medicine.

Troglitazone Decreases the Proportion of Small, Dense LDL and Increases the Resistance of LDL to Oxidation in Obese Subjects

C. Tack, P. Demacker, A. Stalenhoef, 1998, Diabetes Care.

Adenosine Attenuates the Response to Sympathetic Stimuli in Humans

J. Lenders, P. Smits, J. Willemsen, 1991, Hypertension.

Rosuvastatin increases extracellular adenosine formation in humans in vivo: a new perspective on cardiovascular protection.

W. Oyen, O. Boerman, G. Scheffer, 2009, Arteriosclerosis, thrombosis, and vascular biology.

The cardiovascular interaction between caffeine and nicotine in humans

P. Smits, T. Thien, Liesbeth Temme, 1993, Clinical pharmacology and therapeutics.

Placental folate transport and binding are not impaired in pregnancies complicated by fetal growth restriction.

E. Steegers, R. Steegers-Theunissen, F. Russel, 2004, Placenta.

Compared to glibenclamide, repaglinide treatment results in a more rapid fall in glucose level and beta‐cell secretion after glucose stimulation

C. Tack, P. Smits, E. Abbink, 2004, Diabetes/metabolism research and reviews.

Coffee and the human cardiovascular system.

P. Smits, T. Thien, A. van 't Laar, 1987, The Netherlands journal of medicine.

Effects of Insulin on Vascular Tone and Sympathetic Nervous System in NIDDM

C. Tack, J. Lenders, P. Smits, 1996, Diabetes.

Hydroquinine pharmacokinetics after oral administration in adult patients with muscle cramps

A. Verbeek, P. Smits, H. V. van Kan, 2000, European Journal of Clinical Pharmacology.

Circulating adenosine increases during human experimental endotoxemia but blockade of its receptor does not influence the immune response and subsequent organ injury

B. Franke, J. G. van der Hoeven, P. Pickkers, 2011, Critical care.

Rosuvastatin increases extracellular adenosine in humans in vivo: A New perspective on cardiovascular protection

W. Oyen, O. Boerman, G. Scheffer, 2008 .

The 22G>A polymorphism in the adenosine deaminase gene impairs catalytic function but does not affect reactive hyperaemia in humans in vivo

B. Franke, M. Naber, P. Smits, 2008, Pharmacogenetics and genomics.

Reproducibility of blood flow and post-occlusive reactive hyperaemia as measured by venous occlusion plethysmography.

M. Hopman, M. Bleeker, P. Smits, 2005, Clinical science.

A Causal Role for Endothelin-1 in the Vascular Adaptation to Skeletal Muscle Deconditioning in Spinal Cord injury

M. Hopman, P. Pickkers, P. Smits, 2006, Arteriosclerosis, thrombosis, and vascular biology.

Preserved vascular reactivity of rat renal arteries after cold storage.

F. Russel, P. Smits, C. Kramers, 2004, Cryobiology.

Direct vasoactivity of frusemide

P. Pickkers, P. Smits, T. Dormans, 1996, The Lancet.

Effects of the 34C>T Variant of the AMPD1 Gene on Immune Function, Multi-Organ Dysfunction, and Mortality in Sepsis Patients

M. Coenen, S. Vermeulen, J. G. van der Hoeven, 2015, Shock.

The effect of arginine vasopressin on endothelin production in the human forearm vascular bed.

P. Smits, T. Thien, C. Postma, 2005, The Netherlands journal of medicine.

Genetic determinants of impaired awareness of hypoglycemia in type 1 diabetes

A. Paterson, M. Coenen, C. Tack, 2017, Pharmacogenetics and genomics.

Severe vagal response after endotoxin administration in humans

J. G. van der Hoeven, P. Pickkers, P. Smits, 2004, Intensive Care Medicine.

Endothelium and the regulation of vascular tone with emphasis on the role of nitric oxide. Physiology, pathophysiology and clinical implications.

P. Smits, T. Thien, G. Rongen, 1994, Netherlands Journal of Medicine.

PLASMA OBTAINED DURING HUMAN ENDOTOXEMIA INCREASES ENDOTHELIAL ALBUMIN PERMEABILITY IN VITRO

M. Netea, J. G. van der Hoeven, P. Pickkers, 2006, Shock.

Physiological insulin concentrations protect against ischemia-induced loss of cardiac function in rats.

B. Oeseburg, P. Smits, R. J. Legtenberg, 2002, Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.

Calcitonin gene-related peptide induced vasodilation does not depend on the activation of potassium channels in man

L. Bortel, P. Pickkers, P. Smits, 1999 .

The effect of caffeine on renal vein renin concentration in patients with renal arterial disease.

G. Rosenbusch, P. Smits, T. Thien, 1991, American Journal of Hypertension.

Activation of ATP-sensitive potassium channels contributes to reactive hyperemia in humans

P. Ganz, M. Creager, P. Smits, 1996 .

Absence of magnesium sparing effect of a single dose of triamterene in combination with frusemide in healthy male adults.

P. Smits, F. Gribnau, J. van Meyel, 1990, British journal of clinical pharmacology.

Microvascular permeability during experimental human endotoxemia : an open intervention study

P. Pickkers, P. Smits, M. Bouw, 2017 .

Vascular Effects of Pentoxifylline in Humans

P. Smits, T. Thien, Janine A. M. Kamphuis, 1994, Journal of cardiovascular pharmacology.

Assessing the effectiveness of topical betamethasone to treat chronic chilblains: a randomised clinical trial in primary care.

P. Smits, A. Lagro-Janssen, J. Bor, 2017, The British journal of general practice : the journal of the Royal College of General Practitioners.

Endothelin-1 in patients with Raynaud's phenomenon

H. Wollersheim, P. Smits, T. Thien, 1991, The Lancet.

Cell-type-specific downregulation of heme oxygenase-1 by lipopolysaccharide via Bach1 in primary human mononuclear cells.

R. Blasczyk, B. Eiz-Vesper, J. G. van der Hoeven, 2015, Free radical biology & medicine.

Ischaemic preconditioning: from molecular characterisation to clinical application--part I.

P. Smits, G. Rongen, N. Riksen, 2004, Netherlands Journal of Medicine.

Endothelium-Dependent Vascular Relaxation in Patients With Type I Diabetes

P. Smits, J. Lutterman, M. Jacobs, 1993, Diabetes.

Characterization of ATP-induced vasodilation in the human forearm vascular bed.

P. Smits, G. Rongen, T. Thien, 1994, Circulation.

Effect of Long‐Term Angiotensin‐Converting Enzyme Inhibition on Endothelial Function in Patients with the Insulin‐Resistance Syndrome

P. Smits, J. Lutterman, T. Thien, 1995, Journal of cardiovascular pharmacology.

Effect of glycyrrhetinic acid on 11β-hydroxysteroid dehydrogenase activity in normotensive and hypertensive subjects

C. Sweep, B. Walker, J. Lenders, 2002 .

Over a Perfusate Concentration Range of 5 -2 0 /¿g Ml 2 at a Concentration of 5 ¿¿g M L ' \ a Ratio of Renal Clearance over Clearance by Glomerular Ratio Mcreas 1.02 + 0.06 at /ig Ml

P. Smits, R. Masereeuw, M. M. Moons, 2017 .

O R I G I N a L I N V E S T I G a T I O N Open Access

W. Oyen, B. Bravenboer, C. Tack, 2022 .

Atazanavir-induced unconjugated hyperbilirubinemia prevents vascular hyporeactivity during experimental human endotoxemia

J. G. van der Hoeven, P. Pickkers, P. Smits, 2023, Frontiers in Immunology.

Nifedipine vs Placebo for Treatment of Chronic Chilblains: A Randomized Controlled Trial

P. Smits, A. Lagro-Janssen, J. Bor, 2016, The Annals of Family Medicine.