M. Horwitz

发表

Isolation of a Common Receptor for Coxsackie B Viruses and Adenoviruses 2 and 5

J. Bergelson, J. Cunningham, G. Droguett, 1997, Science.

DAP kinase activates a p19ARF/p53-mediated apoptotic checkpoint to suppress oncogenic transformation

Gustavo Droguett, Adi Kimchi, Ronald A. DePinho, 2000, Nature Cell Biology.

An Adenovirus Inhibitor of Tumor Necrosis Factor Alpha-Induced Apoptosis Complexes with Dynein and a Small GTPase

M. Horwitz, S. A. Lukashok, L. Tarassishin, 2000, Journal of Virology.

The Clinical, Immunohematological, and Molecular Study of Iranian Patients with Severe Congenital Neutropenia

C. Klein, N. Rezaei, R. Sherkat, 2007, Journal of Clinical Immunology.

The dl1520 Virus Is Found Preferentially in Tumor Tissue after Direct Intratumoral Injection in Oral Carcinoma

S. Wadler, M. Horwitz, H. Kaufman, 2005, Clinical Cancer Research.

HIF induces human embryonic stem cell markers in cancer cells.

M. Cleary, R. Vessella, M. Bar, 2011, Cancer research.

Expression of adenoviral E3 transgenes in beta cells prevents autoimmune diabetes.

M. V. von Herrath, S. Efrat, M. Horwitz, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Virus-induced autoimmune disease: transgenic approach to mimic insulin-dependent diabetes mellitus and multiple sclerosis.

M. V. von Herrath, M. Horwitz, M. Oldstone, 1996, Current topics in microbiology and immunology.

Whole-organism lineage tracing by combinatorial and cumulative genome editing

James A. Gagnon, A. McKenna, J. Shendure, 2016, Science.

Phylogenetic Fate Mapping: Theoretical and Experimental Studies Applied to the Development of Mouse Fibroblasts

James M Thompson, S. Salipante, M. Horwitz, 2008, Genetics.

Simultaneous brain cell type and lineage determined by scRNA-seq reveals stereotyped cortical development.

A. McKenna, J. Shendure, F. Pauler, 2022, Cell systems.

Simultaneous Identification of Brain Cell Type and Lineage via Single Cell RNA Sequencing

A. McKenna, J. Shendure, F. Pauler, 2021, bioRxiv.

Decoding cell lineage from acquired mutations using arbitrary deep sequencing

B. Preston, A. Kas, S. Salipante, 2011, Nature Methods.

Phylogenetic fate mapping.

S. Salipante, M. Horwitz, 2006, Proceedings of the National Academy of Sciences of the United States of America.

A phylogenetic approach to mapping cell fate.

S. Salipante, M. Horwitz, 2007, Current topics in developmental biology.

Prolonged pharmacological inhibition of cathepsin C results in elimination of neutrophil serine proteases

M. Si-Tahar, M. Horwitz, N. Heuzé-Vourc’h, 2017, Biochemical pharmacology.

Structure-function relationships in Escherichia coli promoter DNA.

L. Loeb, M. Horwitz, Lawrence A. Loeb, 1990, Progress in nucleic acid research and molecular biology.

Targeted transcriptional repression of Gfi1 by GFI1 and GFI1B in lymphoid cells.

Zhijun Duan, C Blake Gilks, H Leighton Grimes, 2004, Nucleic acids research.

Contributions to Neutropenia from PFAAP5 (N4BP2L2), a Novel Protein Mediating Transcriptional Repressor Cooperation between Gfi1 and Neutrophil Elastase

R. Person, Z. Duan, S. Salipante, 2009, Molecular and Cellular Biology.

A Novel Notch Protein, N2N, Targeted by Neutrophil Elastase and Implicated in Hereditary Neutropenia

Z. Duan, Feng-Qian Li, M. Horwitz, 2004, Molecular and Cellular Biology.

Mutations associated with neutropenia in dogs and humans disrupt intracellular transport of neutrophil elastase

G. Acland, R. Person, Z. Duan, 2003, Nature Genetics.

The impact of adenovirus infection on the immunocompromised host

M. Horwitz, T. Kojaoghlanian, P. Flomenberg, 2003, Reviews in medical virology.

Passenger mutations as a marker of clonal cell lineages in emerging neoplasia.

M. Horwitz, J. Salk, 2010, Seminars in cancer biology.

Persistent replication of the modified chimeric adenovirus ONYX-015 in both tumor and stromal cells from a patient with gall bladder carcinoma implants.

S. Wadler, M. Horwitz, A. Rozenblit, 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

Selection of new biological activities from random nucleotide sequences: evolutionary and practical considerations.

L. Loeb, M. Horwitz, D. Dube, 1989, Genome.

The adenovirus E3 14.7-kilodalton protein which inhibits cytolysis by tumor necrosis factor increases the virulence of vaccinia virus in a murine pneumonia model

M. Horwitz, S. Cho, J. Tufariello, 1994, Journal of virology.

Acute lymphoblastic leukemia in a child with Leri-Weill syndrome and complete SHOX gene deletion: A Case Report.

M. Hajdúch, M. Jarošová, V. Mihál, 2018, Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia.

TRANSCRIPTION FACTORS IN HEMATOPOIESIS AND HEMATOLOGIC DISEASE GATA factor mutations in hematologic disease

M. Horwitz, J. Crispino, 2017 .

GATA factor mutations in hematologic disease.

M. Horwitz, J. Crispino, 2017, Blood.

On the mechanism of DNA transfection: efficient gene transfer without viruses

M. Horwitz, A. Coonrod, F. Li, 1997, Gene Therapy.

Lymphoid Enhancer Factor-1 Links Two Hereditary Leukemia Syndromes through Core-binding Factor α Regulation of ELA2*

R. Moon, R. Person, K. Takemaru, 2004, Journal of Biological Chemistry.

Leukemia in Severe Congenital Neutropenia: Defective Proteolysis Suggests New Pathways to Malignancy and Opportunities for Therapy

R. Person, Z. Duan, Feng-Qian Li, 2003, Cancer investigation.

Congenital and acquired neutropenia.

M. Horwitz, T. Loughran, N. Berliner, 2004, Hematology. American Society of Hematology. Education Program.

Role of neutrophil elastase in bone marrow failure syndromes: molecular genetic revival of the chalone hypothesis

R. Person, Z. Duan, Feng-Qian Li, 2003, Current opinion in hematology.

Promoters selected from random DNA sequences.

L. Loeb, M. Horwitz, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Anticipation inFamilial Leukemia

M. Horwitz, 1996 .

THE EFFECT OF CD28/B7 BLOCKADE ON ALLOREACTIVE T AND B CELLS AFTER LIVER CELL TRANSPLANTATION 1

B. Reddy, G. Droguett, M. Horwitz, 2001, Transplantation.

Duffy (Fy), DARC, and neutropenia among women from the United States, Europe and the Caribbean

A. Neugut, E. Ziv, Ying Wei, 2008, British journal of haematology.

Neutropenia in 6 ethnic groups from the Caribbean and the U.S.

Ying Wei, J. Jacobson, M. Horwitz, 2008, Cancer.

Clonal Expansions and Short Telomeres Are Associated with Neoplasia in Early-onset, but not Late-onset, Ulcerative Colitis

M. Bronner, P. Rabinovitch, L. Loeb, 2013, Inflammatory bowel diseases.

Inhibition of Tumor Necrosis Factor Alpha-Induced NF-κB Activation by the Adenovirus E3-10.4/14.5K Complex

J. M. Friedman, M. Horwitz, 2002, Journal of Virology.

Adenovirus Gene Products that Affect Host Immune Mechanisms

M. Horwitz, P. Flomenberg, 1989 .

Identification of a cell protein (FIP-3) as a modulator of NF-κB activity and as a target of an adenovirus inhibitor of tumor necrosis factor α-induced apoptosis

D. Wallach, Jian Kang, M. Horwitz, 1999 .

implications for mechanisms of pathogenesis familial platelet disorder with predisposition to acute myelogenous leukemia: In vitro analyses of known and novel RUNX1/AML1 mutations in dominant

S. Antonarakis, C. Rossier, S. Israels, 2013 .

Adenovirus early region 3(E3) immunomodulatory genes decrease the incidence of autoimmune diabetes in NOD mice.

S. Efrat, M. Horwitz, D. Serreze, 2001, Diabetes.

Adenovirus early region 3 antiapoptotic 10.4K, 14.5K, and 14.7K genes decrease the incidence of autoimmune diabetes in NOD mice.

S. Efrat, M. Horwitz, D. Serreze, 2003, Diabetes.

Target protein interactions of indole‐3‐carbinol and the highly potent derivative 1‐benzyl‐I3C with the C‐terminal domain of human elastase uncouples cell cycle arrest from apoptotic signaling

Kathleen A. Durkin, G. Firestone, M. Preobrazhenskaya, 2012, Molecular carcinogenesis.

Gene trapping in differentiating cell lines: regulation of the lysosomal protease cathepsin B in skeletal myoblast growth and fusion

Bonnie F. Sloane, H. Weintraub, J. Gogos, 1996, The Journal of cell biology.

Intracellular degradation of HeLa and adenovirus type 2 DNA induced by camptothecin.

M. Horwitz, S. Horwitz, S. B. Horwitz, 1971, Biochemical and biophysical research communications.

Differential chemokine induction by the mouse adenovirus type-1 in the central nervous system of susceptible and resistant strains of mice.

C. Brosnan, P. Charles, M. Horwitz, 1999, Journal of neurovirology.

Prolonged survival of pancreatic islet allografts mediated by adenovirus immunoregulatory transgenes.

S. Efrat, M. Horwitz, G. Fejer, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Adenovirus RID (cid:2)(cid:3) Complex Inhibits Lipopolysaccharide Signaling without Altering TLR4 Cell Surface Expression†

M. Horwitz, F. Delgado-Lopez, 2006 .

Mutations in the zinc finger domain of IKK gamma block the activation of NF-kappa B and the induction of IL-2 in stimulated T lymphocytes.

M. Horwitz, A. S. Shifera, 2008, Molecular immunology.

Identification of a cell protein (FIP-3) as a modulator of NF-kappaB activity and as a target of an adenovirus inhibitor of tumor necrosis factor alpha-induced apoptosis.

J. Ye, D. Wallach, M. Horwitz, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Adenovirus immunoregulatory genes and their cellular targets.

M. Horwitz, Marshall S. Horwitz, 2001, Virology.

Regulation of the NF-κB Activation Pathway by Isolated Domains of FIP3/IKKγ, a Component of the IκB-α Kinase Complex*

M. Horwitz, Jianjiang Ye, L. Tarassishin, 2000, The Journal of Biological Chemistry.

The association of thymidine kinase activity and thymidine transport in Escherichia coli.

L. Loeb, M. Horwitz, D. Dube, 1991, Gene.

Expression of enzymatically active adenovirus DNA polymerase from cloned DNA requires sequences upstream of the main open reading frame.

J. Engler, M. Horwitz, L. Shu, 1987, Virology.

Inhibition of Adenovirus DNA Synthesis In Vitro by Sera from Patients with Systemic Lupus Erythematosus

M. Horwitz, H. Keiser, B. Friefeld, 1982, Molecular and cellular biology.

The Role of FIP-2 (optineurin) in Regulation of the Chemokines and Kinases

M. Horwitz, L. Tarassishin, 2014 .

Function of adenovirus E3 proteins and their interactions with immunoregulatory cell proteins

M. Horwitz, 2004, The journal of gene medicine.

A non-immunogenic adenoviral vector, coexpressing CTLA4Ig and bilirubin-uridine-diphosphoglucuronateglucuronosyltransferase permits long-term, repeatable transgene expression in the Gunn rat model of Crigler–Najjar syndrome

S. Lee, S. Ghosh, B. Reddy, 2002, Gene Therapy.

Analysis in vitro of Mutations in the Cloned Precursor to the Terminal Protein (pTP) and the Adenovirus DNA Polymerase (Ad Pol) Genes

S. Pettit, J. Engler, M. Horwitz, 1992 .

Lentivectors encoding immunosuppressive proteins genetically engineer pancreatic β-cells to correct diabetes in allogeneic mice

M. Horwitz, N. Fleischer, T. DiLorenzo, 2009, Gene Therapy.

Inhibition of Chemokine Expression by Adenovirus Early Region Three (E3) Genes

A. Lesokhin, M. Horwitz, F. Delgado-Lopez, 2002, Journal of Virology.

A family inheriting different subtypes of acute myelogenous leukemia

M. Horwitz, D. Sabath, W. A. Smithson, 1994, American journal of hematology.

Characterisation of a compound in-cis GATA2 germline mutation in a pedigree presenting with myelodysplastic syndrome/acute myeloid leukemia with concurrent thrombocytopenia

H. Scott, M. Horwitz, P. Venugopal, 2015, Leukemia.

Possibility of somatic mosaicism of ELA2 mutation overlooked in an asymptomatic father transmitting severe congenital neutropenia to two offspring.

M. Horwitz, K. Benson, 2002 .

Linker insertion mutations in the adenovirus preterminal protein that affect DNA replication activity in vivo and in vitro

S. Pettit, J. Engler, M. Horwitz, 1991, Journal of virology.

G-CSF receptor mutations mix it up

M. Horwitz, 2005 .

GTPase Complexes with Dynein and a Small Factor Alpha-Induced Apoptosis An Adenovirus Inhibitor of Tumor Necrosis

M. Horwitz, S. A. Lukashok, L. Tarassishin, 2000 .

Mechanism for Removal of Tumor Necrosis Factor Receptor 1 from the Cell Surface by the Adenovirus RIDα/β Complex

M. Horwitz, Y. Chin, 2005, Journal of Virology.

IKKγ (NEMO) is involved in the coordination of the AP-1 and NF-κB pathways

J. M. Friedman, M. Horwitz, A. S. Shifera, 2008, Molecular and Cellular Biochemistry.

Sites on FIP-3 (NEMO/IKKγ) Essential for Its Phosphorylation and NF-κB Modulating Activity

M. Horwitz, L. Tarassishin, 2001 .

Biliary atresia and reovirus type 3 infection.

M. Horwitz, S. Cho, W. Balistreri, 1982, The New England journal of medicine.

Intermediates in the Synthesis of Type 2 Adenovirus Deoxyribonucleic Acid

M. Horwitz, 1971, Journal of virology.

Hepatic gene transfer of the catalytic subunit of the apolipoprotein B mRNA editing enzyme results in a reduction of plasma LDL levels in normal and watanabe heritable hyperlipidemic rabbits.

M. Horwitz, N. Chowdhury, J. Chowdhury, 1996, Journal of lipid research.

Gfi1 Coordinates Epigenetic Repression of p21Cip/WAF1 by Recruitment of Histone Lysine Methyltransferase G9a and Histone Deacetylase 1

Z. Duan, H. Grimes, M. Horwitz, 2005, Molecular and Cellular Biology.

Evidence for the involvement of cathepsin B in skeletal myoblast differentiation

Bonnie F. Sloane, M. Horwitz, J. Koblinski, 2002, Journal of cellular biochemistry.

Synthesis of type 2 Adenovirus DNA in the Presence of Cycloheximide

M. Horwitz, S. Baum, C. Brayton, 1973, Journal of virology.

Model systems for studying the effects of adenovirus E3 genes on virulence in vivo.

M. Horwitz, G. Fejer, J. Tufariello, 1995, Current topics in microbiology and immunology.

Targets of the transcriptional repressor oncoprotein Gfi-1

Zhijun Duan, Z. Duan, M. Horwitz, 2003, Proceedings of the National Academy of Sciences of the United States of America.

(prokaryotic expression vector/chloramphenicol-affinity purification)

J. Sninsky, M. Horwitz, B. Friefeld, 2016 .

Phylogenetic analysis of developmental and postnatal mouse cell lineages

A. Kas, S. Salipante, M. Horwitz, 2010, Evolution & development.

Evolution of adenoviruses as gene therapy vectors.

J. Roy-Chowdhury, M. Horwitz, 2002, Molecular therapy : the journal of the American Society of Gene Therapy.

Expression of adenoviral E3 transgenes in b cells prevents autoimmune diabetes (insulin-dependent diabetes mellitusylymphocytic choriomeningitis virusymajor histocompatibility complex expression)

S. Efrat, M. Horwitz, M. Herrath, 1997 .

Insertion of the adenoviral E3 region into a recombinant viral vector prevents antiviral humoral and cellular immune responses and permits long-term gene expression.

G. Droguett, M. Horwitz, N. Chowdhury, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Chinese hamster ovary cells replicate adenovirus deoxyribonucleic acid

M. Horwitz, M. Longiaru, 1981, Molecular and cellular biology.

A cleavage product of the adenovirus DNA binding protein is active in DNA replication in vitro.

A. Levine, H. Ariga, M. Horwitz, 1980, Virology.

Synthesis and assembly of adenovirus polypeptides. III. Reversible inhibition of hexon assembly in adenovirus type 5 temperature-sensitive mutants.

M. Horwitz, J. Leibowitz, 1975, Virology.

Molecular Weight of Adenovirus Type 2 Hexon Polypeptide

J. Maizel, M. Horwitz, M. Scharff, 1970, Journal of virology.

The in vitro replication of adenovirus DNA.

J. Hurwitz, K. Nagata, R. Gronostajski, 1984, Current topics in microbiology and immunology.

Bidirectional replication of adenovirus type 2 DNA

M. Horwitz, 1976, Journal of virology.

Tumor necrosis factor-α and CD40L modulate cell surface morphology and induce aggregation in Ramos Burkitt's lymphoma cells

M. Horwitz, R. Laskov, M. Scharff, 2006 .

Heritable GATA2 Mutations Associated with Familial Myelodysplastic Syndrome and Acute Myeloid Leukemia

Anna L. Brown, Ian D. Lewis, Sarah Moore, 2011, Nature Genetics.

GATA2 deficiency: flesh and blood.

M. Horwitz, 2014, Blood.

Adenovirus RID complex enhances degradation of internalized tumour necrosis factor receptor 1 without affecting its rate of endocytosis.

M. Horwitz, Y. Chin, 2006, The Journal of general virology.

Inhibition of Tumor Necrosis Factor (TNF) Signal Transduction by the Adenovirus Group C RID Complex Involves Downregulation of Surface Levels of TNF Receptor 1

M. Horwitz, S. Fessler, Y. Chin, 2004, Journal of Virology.

Effects of camptothecin on the breakage and repair of DNA during the cell cycle.

M. Horwitz, S. Horwitz, 1973, Cancer research.

Mitochondrial DNA synthesis in adenovirus type 2-infected HeLa cells

P. Fisher, M. Horwitz, 1977, Journal of virology.

Location of the Origin of DNA Replication in Adenovirus Type 2

M. Horwitz, 1974, Journal of virology.

Camptothecin: mechanism of inhibition of adenovirus formation.

M. Horwitz, C. Brayton, 1972, Virology.

in a murine pneumonia model . factor increases the virulence of vaccinia virus which inhibits cytolysis by tumor necrosis The adenovirus E 3 14 . 7-kilodalton protein

M. Horwitz, S. Cho, J. Tufariello, 2022 .

Anticipation in familial leukemia.

E. Goode, G. Jarvik, M. Horwitz, 1996, American journal of human genetics.

Targeted correction of RUNX1 mutation in FPD patient-specific induced pluripotent stem cells rescues megakaryopoietic defects.

E. Kwon, A. Elkahloun, Linzhao Cheng, 2014, Blood.

PLATELETS AND THROMBOPOIESIS Targeted correction of RUNX1 mutation in FPD patient-speci ﬁ c induced pluripotent stem cells rescues megakaryopoietic defects

E. Kwon, A. Elkahloun, Linzhao Cheng, 2014 .

In vitro analyses of known and novel RUNX1/AML1 mutations in dominant familial platelet disorder with predisposition to acute myelogenous leukemia: implications for mechanisms of pathogenesis.

Yoshiaki Ito, Joëlle Michaud, Hamish S Scott, 2002, Blood.

Neutrophil Elastase, Proteinase 3, and Cathepsin G as Therapeutic Targets in Human Diseases

M. Horwitz, B. Korkmaz, D. Jenne, 2010, Pharmacological Reviews.

ELANE mutations in cyclic and severe congenital neutropenia: genetics and pathophysiology.

S. Corey, H. Grimes, M. Horwitz, 2013, Hematology/oncology clinics of North America.

The effect of aphidicolin on adenovirus DNA synthesis.

J. Ikeda, M. Horwitz, S. Horwitz, 1979, Nucleic acids research.

The DNA polymerases associated with the adenovirus type 2 replication complex: effect of 2'-3'-dideoxythymidine-5'-triphosphate on viral DNA synthesis.

M. Horwitz, M. Abboud, 1979, Nucleic acids research.

CHARACTERIZATION OF ADENOVIRUS ISOLATES FROM AIDS PATIENTS a

Roman Kern, M. Horwitz, I. Spigland, 1984, Annals of the New York Academy of Sciences.

ADENOVIRUS ISOLATES FROM URINE OF PATIENTS WITH ACQUIRED IMMUNODEFICIENCY SYNDROME

M. Horwitz, I. Spigland, P. D. Jong, 1983, The Lancet.

Epigenetic Regulation of Protein-Coding and MicroRNA Genes by the Gfi1-Interacting Tumor Suppressor PRDM5

Zhijun Duan, H. Leighton Grimes, Hu-Hui Lee, 2007, Molecular and Cellular Biology.

Mutations in the gene encoding neutrophil elastase in congenital and cyclic neutropenia.

C Bos, R. Person, K. Welte, 2000, Blood.

Mutations in ELA2, encoding neutrophil elastase, define a 21-day biological clock in cyclic haematopoiesis

David C. Dale, R. Person, M. Horwitz, 1999, Nature Genetics.

Lymphoproliferative diseases of fowl--immunologic factors associated with passage of a lymphoblastic leukemia (JM-V).

M. Horwitz, M. Sevoian, C. Helmboldt, 1969, Avian diseases.

Characterization of transgenic mice containing adenovirus early region 3 genomic DNA

M. Horwitz, G. Fejer, I. Győry, 1994, Journal of virology.

A family epidemic of vaccinia

M. Horwitz, P. Solomon, 1966 .

Immunoreactivity to antinucleoside antibodies in camptothecin treated HeLa cells.

M. Horwitz, S. Horwitz, K. Hsu, 1974, Experimental cell research.

Inducible expression of a disease-associated ELANE mutation impairs granulocytic differentiation, without eliciting an unfolded protein response

S. Corey, M. Horwitz, B. Garg, 2020, The Journal of Biological Chemistry.

Pathogenesis of ELANE-mutant severe neutropenia revealed by induced pluripotent stem cells.

Patrick J. Paddison, B. Aronow, P. Paddison, 2015, The Journal of clinical investigation.

The Murine CAR Homolog Is a Receptor for Coxsackie B Viruses and Adenoviruses

J. Bergelson, G. Droguett, A. Krithivas, 1998, Journal of Virology.

An E. coli promoter that regulates transcription by DNA superhelix-induced cruciform extrusion.

L. Loeb, M. Horwitz, Marshall S. Horwitz, 1988, Science.

Mutations in proto-oncogene GFI1 cause human neutropenia and target ELA2

George Eliopoulos, Zhijun Duan, Christina Kaufman, 2003, Nature Genetics.

Novel human endogenous sequences related to human immunodeficiency virus type 1

M. Boyce-Jacino, M. Horwitz, A. Faras, 1992, Journal of virology.

Molecular epidemiology of adenovirus type 35 infections in immunocompromised hosts.

M. Chen, M. Horwitz, P. Flomenberg, 1987, The Journal of infectious diseases.

Mouse adenovirus type-1 replication is restricted to vascular endothelium in the CNS of susceptible strains of mice.

C. Brosnan, P. Charles, M. Horwitz, 1998, Virology.

Mouse adenovirus type 1 causes a fatal hemorrhagic encephalomyelitis in adult C57BL/6 but not BALB/c mice

L. Pirofski, C. Brosnan, M. Horwitz, 1995, Journal of virology.

Studies of the Mechanism of Enhancement of Human Adenovirus Infection in Monkey Cells by Simian Virus 40

J. Maizel, M. Horwitz, S. Baum, 1972, Journal of virology.

Interaction of an Adenovirus E3 14.7-Kilodalton Protein with a Novel Tumor Necrosis Factor Alpha-Inducible Cellular Protein Containing Leucine Zipper Domains

Jian Kang, M. Horwitz, Yongan Li, 1998, Molecular and Cellular Biology.

Interaction of an adenovirus 14.7-kilodalton protein inhibitor of tumor necrosis factor alpha cytolysis with a new member of the GTPase superfamily of signal transducers

Y. Li, M. Horwitz, J. Kang, 1997, Journal of virology.

Sequence of the immunoregulatory early region 3 and flanking sequences of adenovirus type 35.

C. Basler, G. Droguett, M. Horwitz, 1996, Gene.

Artificial mutants generated by the insertion of random oligonucleotides into the putative nucleoside binding site of the HSV-1 thymidine kinase gene.

L. Loeb, M. Horwitz, D. Dube, 1991, Biochemistry.

Integrative analysis of RUNX1 downstream pathways and target genes

Matthew E Ritchie, Matthew E. Ritchie, Terence P Speed, 2008, BMC Genomics.

Genetic heterogeneity in familial acute myelogenous leukemia: evidence for a second locus at chromosome 16q21-23.2.

R I Richards, M. Leppert, R. Richards, 1997, American journal of human genetics.

HIF1α induced switch from bivalent to exclusively glycolytic metabolism during ESC‐to‐EpiSC/hESC transition

C. Ware, H. Ruohola-Baker, Jennifer Hesson, 2012, The EMBO journal.

Targeting of DNA polymerase to the adenovirus origin of DNA replication by interaction with nuclear factor I.

N. Mermod, M. Horwitz, M. Armentero, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Mechanisms and clinical applications of chromosomal instability in lymphoid malignancy

M. Krem, M. Horwitz, O. Press, 2015, British journal of haematology.

Correction: The Genomic Landscape of the Ewing Sarcoma Family of Tumors Reveals Recurrent STAG2 Mutation

Jun S. Wei, T. Triche, A. Llombart‐Bosch, 2014, PLoS Genetics.

Clonal expansions in ulcerative colitis identify patients with neoplasia

M. Bronner, P. Rabinovitch, L. Loeb, 2009, Proceedings of the National Academy of Sciences.

Adenovirus preterminal protein synthesized in COS cells from cloned DNA is active in DNA replication in vitro

S. Pettit, J. Engler, M. Horwitz, 1988, Journal of virology.

Activating PAX gene family paralogs to complement PAX5 leukemia driver mutations

Matthew R Hart, T. Neff, M. Horwitz, 2018, PLoS genetics.

Chromosome band 16q22‐linked familial AML: Exclusion of candidate genes, and possible disease risk modification by NQO1 polymorphisms

O. Olopade, H. Scott, M. Horwitz, 2004, Genes, chromosomes & cancer.

Whole-organism lineage tracing by combinatorial and cumulative genome editing

James A. Gagnon, A. McKenna, J. Shendure, 2016, Science.

Assessment of Hypoxia Inducible Factor Levels in Cancer Cell Lines upon Hypoxic Induction Using a Novel Reporter Construct

R. Moon, H. Ruohola-Baker, T. Biechele, 2011, PloS one.

Germline ETV6 mutations in familial thrombocytopenia and hematologic malignancy

David A. Williams, T. Walsh, M. King, 2015, Nature Genetics.

Isolation of proteins involved in the replication of adenoviral DNA in vitro.

J. Hurwitz, J. Ikeda, K. Nagata, 1983, Cold Spring Harbor symposia on quantitative biology.

Functional interactions of the domains of the adenovirus DNA binding protein.

M. Horwitz, M. Krevolin, 1987, Virology.

Effects of the adenovirus H5ts125 and H5ts107 DNA binding proteins on DNA replication in vitro.

M. Horwitz, M. Krevolin, B. Friefeld, 1983, Virology.

Temperature-sensitive replication of H5ts125 adenovirus DNA in vitro.

M. Horwitz, 1978, Proceedings of the National Academy of Sciences of the United States of America.

Replication of an adenovirus type 34 mutant DNA containing tandem reiterations of the inverted terminal repeat.

M. Chen, M. Horwitz, M. Chen, 1990, Virology.

Mutagenesis of conserved region I in the DNA polymerase from human adenovirus serotype 2.

J. Engler, M. Horwitz, I. Joung, 1991, Virology.

Mutations of the precursor to the terminal protein of adenovirus serotypes 2 and 5

S. Pettit, J. Engler, M. Horwitz, 1989, Journal of virology.

Adenovirus DNA synthesis in vitro is inhibited by the virus-coded major core protein.

M. Horwitz, R. Korn, 1986, Virology.

A recurrent germline PAX5 mutation confers susceptibility to pre-B cell acute lymphoblastic leukemia

Rohini Rau-Murthy, Jinghui Zhang, Kenneth Offit, 2013, Nature Genetics.

Synthesis and assembly of adenovirus type 2 polypeptides. II. Reversible inhibition of hexon assembly at 42

M. Horwitz, J. Leibowitz, 1974 .

Complementation of the temperature-sensitive defect in H5ts125 adenovirus DNA replication in vitro.

J. Hurwitz, H. Ariga, L. Kaplan, 1979, Proceedings of the National Academy of Sciences of the United States of America.

Adenovirus DNA replication in soluble extracts of infected cell nuclei.

L. Kaplan, L. Chow, M. Horwitz, 1979, Cold Spring Harbor symposia on quantitative biology.

Protein-protein interactions between adenovirus DNA polymerase and nuclear factor I mediate formation of the DNA replication preinitiation complex.

N. Mermod, M. Chen, M. Horwitz, 1990, The Journal of biological chemistry.

Separation of the adenovirus terminal protein precursor from its associated DNA polymerase: role of both proteins in the initiation of adenovirus DNA replication.

J. Hurwitz, J. Field, M. Horwitz, 1982, Proceedings of the National Academy of Sciences of the United States of America.

Formation of a covalent complex between the 80,000-dalton adenovirus terminal protein and 5'-dCMP in vitro.

J. Hurwitz, M. Horwitz, J. Lichy, 1981, Proceedings of the National Academy of Sciences of the United States of America.

Multiple rounds of adenovirus DNA synthesis in vitro.

H. Ariga, M. Horwitz, 1981, Proceedings of the National Academy of Sciences of the United States of America.

Evidence for an altered adenovirus DNA polymerase in cells infected with the mutant H5ts149.

J. Hurwitz, M. Horwitz, J. Lichy, 1983, Proceedings of the National Academy of Sciences of the United States of America.

RUNX1-mutated families show phenotype heterogeneity and a somatic mutation profile unique to germline predisposed AML.

Anna L. Brown, Paul P. S. Wang, S. Fröhling, 2020, Blood advances.

GATA2 deficiency and related myeloid neoplasms

Matthew Collin, M. Wlodarski, M. Horwitz, 2017, Seminars in hematology.

Oral tolerization to adenoviral proteins permits repeated adenovirus‐mediated gene therapy in rats with pre‐existing immunity to adenoviruses

M. Ott, B. Reddy, G. Droguett, 1998, Hepatology.

Long Term Correction of Bilirubin-UDP-glucuronosyltransferase Deficiency in Gunn Rats by Administration of a Recombinant Adenovirus during the Neonatal Period*

M. Horwitz, N. Chowdhury, J. Chowdhury, 1996, The Journal of Biological Chemistry.

Oral tolerization to adenoviral antigens permits long-term gene expression using recombinant adenoviral vectors.

G. Droguett, M. Horwitz, N. Chowdhury, 1997, The Journal of clinical investigation.

Induction of central tolerance by intrathymic inoculation of adenoviral antigens into the host thymus permits long-term gene therapy in Gunn rats.

M. Horwitz, N. Chowdhury, J. Chowdhury, 1996, The Journal of clinical investigation.

Loss-of-function germline GATA2 mutations in patients with MDS/AML or MonoMAC syndrome and primary lymphedema reveal a key role for GATA2 in the lymphatic vasculature.

J. Rosenfeld, T. Walsh, S. Holland, 2012, Blood.

Mutations in growth factor independent-1 associated with human neutropenia block murine granulopoiesis through colony stimulating factor-1.

John O. Trent, H. Leighton Grimes, S. Bertolone, 2008, Immunity.

The genetics of familial leukemia

M. Horwitz, Marshall S. Horwitz, 1997, Leukemia.

Support for the N-methyl-D-aspartate receptor hypofunction hypothesis of schizophrenia from exome sequencing in multiplex families.

Carl Baker, Santhosh Girirajan, Michael O Dorschner, 2013, JAMA psychiatry.

Neutrophil elastase in cyclic and severe congenital neutropenia.

Stephen J Salipante, Zhijun Duan, Hu-Hui Lee, 2007, Blood.

Genome Sequencing of Idiopathic Pulmonary Fibrosis in Conjunction with a Medical School Human Anatomy Course

John I. Clark, J. Shendure, Gregory M. Findlay, 2014, PloS one.

Neutrophil elastase: Nonsense lost in translation.

M. Horwitz, 2021, Cell stem cell.

Double de novo mutations of ELA2 in cyclic and severe congenital neutropenia

S. Salipante, N. Rezaei, M. Horwitz, 2007, Human mutation.

Heritable GATA2 mutations associated with familial AML-MDS: a case report and review of literature

O. Frankfurt, L. Peterson, J. Altman, 2014, Journal of Hematology & Oncology.

PHAGOCYTES , GRANULOCYTES , AND MYELOPOIESIS Neutropenia-associated ELANE mutations disrupting translation initiation produce novel neutrophil elastase isoforms

S. Corey, S. Salipante, H. Grimes, 2014 .

Neutropenia-Associated Mutations of PFAAP5, a Novel Protein Mediating Transcriptional Repressor Interaction between Gfi1 and Neutrophil Elastase.

R. Badolato, R. Person, S. Salipante, 2006 .

Lymphadenopathy as the primary manifestation of malignant transformation in two patients with severe congenital neutropenia

M. Borowitz, M. Horwitz, J. Strouse, 2008, Pediatric blood & cancer.

Hereditary neutropenia: dogs explain human neutrophil elastase mutations.

Zhijun Duan, R. Person, Z. Duan, 2004, Trends in molecular medicine.

Restoring RUNX1 deficiency in RUNX1 familial platelet disorder by inhibiting its degradation.

J. A. Maguire, Matthew R Hart, P. Gadue, 2021, Blood advances.

Neutropenia-Associated Mutations in PRDM5, a Novel Epigenetic Regulator of Hematopoiesis.

R. Badolato, R. Person, Z. Duan, 2006 .

Low levels of serum elastase are not associated with mutations in ELA-2 elastase encoding gene in chronic idiopathic neutropenia.

M. Horwitz, H. Papadaki, G. Eliopoulos, 2003, Blood.

Mutations in a gene encoding a midbody protein in binucleated Reed-Sternberg cells of Hodgkin lymphoma

M. Krem, S. Salipante, M. Horwitz, 2010, Cell cycle.

KLHDC8B in Hodgkin lymphoma and possibly twinning

M. Horwitz, A. Timms, 2010, Communicative & integrative biology.

Mutations in a gene encoding a midbody kelch protein in familial and sporadic classical Hodgkin lymphoma lead to binucleated cells

K. Offit, M. Tucker, T. Kirchhoff, 2009, Proceedings of the National Academy of Sciences.

Pseudoautosomal linkage of Hodgkin disease.

M. Horwitz, P. Wiernik, 1999, American journal of human genetics.

Characterization of Mutant Neutrophil Elastase in Severe Congenital Neutropenia*

Feng-Qian Li, M. Horwitz, F Q Li, 2001, The Journal of Biological Chemistry.

Mice expressing a neutrophil elastase mutation derived from patients with severe congenital neutropenia have normal granulopoiesis.

D. Link, M. Horwitz, Daniel C Link, 2002, Blood.

Contributions to Neutropenia from PFAAP5 (N4BP2L2), a Novel Protein Mediating Transcriptional Repressor Cooperation between Gfi1 and Neutrophil Elastase

R. Person, Z. Duan, S. Salipante, 2009 .

GATA2 in the lymphatic vasculature or MonoMAC syndrome and primary lymphedema reveal a key role for mutations in patients with MDS/AML GATA2 Loss-of-function germline

J. Rosenfeld, S. Holland, G. Secker, 2012 .

Synthesis and assembly of adenovirus 2. I. Polypeptide synthesis, assembly of capsomeres, and morphogenesis of the virion.

J. Maizel, M. Horwitz, M. Scharff, 1969, Virology.

Use of somatic mutations to quantify random contributions to mouse development

H. Ruohola-Baker, S. Salipante, M. Horwitz, 2013, BMC Genomics.

Gfi-1 takes center stage in hematopoietic stem cells.

Z. Duan, M. Horwitz, 2005, Trends in molecular medicine.

Atypical exanthem following exposure to natural measles: Eleven cases in children previously inoculated with killed vaccine

P. Nader, M. Horwitz, J. Rousseau, 1968 .

Paradoxical homozygous expression from heterozygotes and heterozygous expression from homozygotes as a consequence of transcriptional infidelity through a polyadenine tract in the AP3B1 gene responsible for canine cyclic neutropenia.

R. Person, Feng-Qian Li, M. Horwitz, 2004, Nucleic acids research.

Susceptibility gene for familial acute myeloid leukemia associated with loss of 5q and/or 7q is not localized on the commonly deleted portion of 5q

O. Olopade, N. Zhao, E. Freireich, 2000, Genes, chromosomes & cancer.

Use of green fluorescent protein in studies of apoptosis of transfected cells.

Y. Li, M. Horwitz, Y. Li, 1997, BioTechniques.

Gfi-1 Oncoproteins in Hematopoiesis

Z. Duan, M. Horwitz, 2003, Hematology.

Subgroup B adenovirus type 35 early region 3 mRNAs differ from those of the subgroup C adenoviruses.

C. Basler, M. Horwitz, 1996, Virology.

GATA2 is a New Predisposition Gene for Familial Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukemia (AML)

Anna L. Brown, K. Friend, P. Ekert, 2010 .

Genome sequencing in a case of Niemann–Pick type C

J. Shendure, T. Bird, S. Srivatsan, 2016, Cold Spring Harbor molecular case studies.

Dissection of functional domains of adenovirus DNA polymerase by linker-insertion mutagenesis.

M. Chen, M. Horwitz, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Selection of a Dominant Negative Retinoblastoma Protein (RB) Inhibiting Satellite Myoblast Differentiation Implies an Indirect Interaction between MyoD and RB

Feng-Qian Li, M. Horwitz, A. Coonrod, 2000, Molecular and Cellular Biology.

Adenovirus RIDαβ Complex Inhibits Lipopolysaccharide Signaling without Altering TLR4 Cell Surface Expression

M. Horwitz, F. Delgado-Lopez, 2006, Journal of Virology.

Preferential MyoD homodimer formation demonstrated by a general method of dominant negative mutation employing fusion with a lysosomal protease

M. Horwitz, A. Coonrod, F. Li, 1996, The Journal of cell biology.

Multiple functions of the adenovirus DNA-binding protein are required for efficient viral DNA synthesis.

D. Brough, D. Klessig, G. Droguett, 1993, Virology.

Purification and functional characterization of adenovirus ts111A DNA-binding protein. Fluorescence studies of protein-nucleic acid binding.

J. W. Chase, K. Williams, M. Horwitz, 1990, The Journal of biological chemistry.

A major internal initiation site for the in vitro translation of the adenovirus DNA polymerase.

M. Horwitz, D. Hassin, R. Korn, 1986, Virology.

Sequence and genetic organization of adenovirus type 35 early region 3

M. Chen, M. Horwitz, P. Flomenberg, 1988, Journal of virology.

Replication of adenovirus type 2 DNA in vitro.

L. Kaplan, M. Horwitz, R. E. Kelinman, 1977, Proceedings of the National Academy of Sciences of the United States of America.

Characterization of a major histocompatibility complex class I antigen-binding glycoprotein from adenovirus type 35, a type associated with immunocompromised hosts

M. Chen, M. Horwitz, P. Flomenberg, 1987, Journal of virology.

Further evidence for a pseudoautosomal gene for Hodgkin's lymphoma: Reply to ‘The familial risk of Hodgkin's lymphoma ranks among the highest in the Swedish Family-Cancer Database’ by Altieri A and Hemminki K

M. Horwitz, M. E. Mealiffe, 2007, Leukemia.

The metabolic and molecular bases of inherited disease on CD-ROM: edited by C.R. Scriver, A.L. Beaudet, W.S. Sly and D. Valle McGraw-Hill, 1997. £299.95/US$345.00 ISBN 1 007864187 X

M. Horwitz, 1997 .

The Kelch Protein KLHDC8B Guards against Mitotic Errors, Centrosomal Amplification, and Chromosomal Instability

M. Krem, M. Horwitz, P. Luo, 2012, The Journal of Biological Chemistry.

AWARD NUMBER: W81XWH-13-1-0066 TITLE: Translational Control in Bone Marrow Failure PRINCIPAL INVESTIGATOR:

M. Horwitz, 2016 .

Translational Control in Bone Marrow Failure

M. Horwitz, 2014 .

Mechanism for removal of tumor necrosis factor receptor 1 from the cell surface by the adenovirus RIDalpha/beta complex.

M. Horwitz, Y. Chin, 2005, Journal of Virology.

Prevention of hepatocyte allograft rejection in rats by transferring adenoviral early region 3 genes into donor cells

C. Guha, J. Roy-Chowdhury, M. Horwitz, 2007, Hepatology.

The mouse adenovirus type 1 contains an unusual E3 region

M. Horwitz, K. Raviprakash, A. Grunhaus, 1989, Journal of virology.

New perspectives in adenoviruses.

M. Horwitz, S. A. Lukashok, 1998, Current clinical topics in infectious diseases.

Case Report of an Adolescent Male With Unexplained Pancytopenia: GATA2-Associated Bone Marrow Failure and Genetic Testing

M. Horwitz, R. Abraham, A. Lorenzana, 2017, Global pediatric health.

The 140-kDa adenovirus DNA polymerase is recognized by antibodies to Escherichia coli-synthesized determinants predicted from an open reading frame on the adenovirus genome.

P. D. de Jong, J. Sninsky, M. Horwitz, 1985, Proceedings of the National Academy of Sciences of the United States of America.

Normal peripheral blood neutrophil numbers accompanying ELANE whole gene deletion mutation.

M. Horwitz, M. Laurino, Siobán B. Keel, 2019, Blood advances.

Novel Isoforms of Neutrophil Elastase Produced by Neutropenia-Associated Mutations of the Initiation Codon and an Internal Ribosomal Entry Site (IRES) of ELANE

M. Horwitz, J. Wechsler, T. Tidwell, 2012 .

Regulation of the NF-kappaB activation pathway by isolated domains of FIP3/IKKgamma, a component of the IkappaB-alpha kinase complex.

J. Ye, M. Horwitz, L. Tarassishin, 2000, The Journal of biological chemistry.

Comparative studies of biliary atresia in the human newborn and reovirus-induced cholangitis in weanling mice.

M. Horwitz, L. Gartner, R. Morecki, 1980, Laboratory investigation; a journal of technical methods and pathology.

cyclic neutropenia Mutations in the gene encoding neutrophil elastase in congenital and

K. Welte, M. Horwitz, D. Dale, 2013 .

Breakpoint Analysis of Transcriptional and Genomic Profiles Uncovers Novel Gene Fusions Spanning Multiple Human Cancer Types

Jonathan R. Pollack, Robert B. West, Nicole Clarke, 2013, PLoS genetics.

Ccdc94 Protects Cells from Ionizing Radiation by Inhibiting the Expression of p53

Bridgid E Hast, L. Zon, A. Look, 2012, PLoS genetics.

No evidence for core-binding factor CBFβ as a leukemia predisposing factor in chromosome 16q22-linked familial AML

O. Olopade, H. Scott, J. Michaud, 2004, Leukemia.

A Systems Genetics Approach Identifies CXCL14, ITGAX, and LPCAT2 as Novel Aggressive Prostate Cancer Susceptibility Genes

Ying Hu, Suiyuan Zhang, Jonathan Andreas, 2014, PLoS genetics.

Neutrophil elastase unleashed

M. Horwitz, 2005 .

Adenovirus, Infection and Immunity

L. Pirofski, M. Horwitz, 1998 .

Adenovirus E3 14.7-kilodalton protein, an antagonist of tumor necrosis factor cytolysis, increases the virulence of vaccinia virus in severe combined immunodeficient mice.

M. Horwitz, S. Cho, J. Tufariello, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Cell-Cycle Dependent Expression of a Translocation-Mediated Fusion Oncogene Mediates Checkpoint Adaptation in Rhabdomyosarcoma

C. Keller, J. Michalek, A. Wagers, 2014, PLoS genetics.

Mechanisms of dominant congenital neutropenias

S. Salipante, M. Horwitz, 2005 .

DNA sequences of random origin as probes of Escherichia coli promoter architecture.

L. Loeb, M. Horwitz, L A Loeb, 1988, The Journal of biological chemistry.

Elongation of primed DNA templates by eukaryotic DNA polymerases.

J. Hurwitz, J. Ikeda, M. Horwitz, 1980, Proceedings of the National Academy of Sciences of the United States of America.

Support for the N-methyl-D-aspartate receptor hypofunction hypothesis of schizophrenia from exome sequencing in multiplex families.

E. Eichler, O. Korvatska, K. Roche, 2013, JAMA psychiatry.

An extrahepatic bile duct growth factor: In vivo effect and preliminary characterization

M. Horwitz, R. Morecki, J. Glaser, 1987, Hepatology.

HIF induces human embryonic stem cell markers in cancer cells.

M. Cleary, R. Vessella, M. Bar, 2011, Cancer research.

Neutropenia in 6 ethnic groups from the Caribbean and the U.S.

Ying Wei, M. Horwitz, V. Grann, 2008, Cancer.

Adenovirus E3 MHC inhibitory genes but not TNF/Fas apoptotic inhibitory genes expressed in β cells prevent autoimmune diabetes

M. V. von Herrath, S. Efrat, M. Horwitz, 2009, Proceedings of the National Academy of Sciences.

Poor prognosis in familial acute myeloid leukaemia with combined biallelic CEBPA mutations and downstream events affecting the ATM, FLT3 and CDX2 genes

T. Speed, H. Bengtsson, H. Scott, 2010, British journal of haematology.

Phylogenetic fate mapping.

S. Salipante, M. Horwitz, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Passenger mutations as a marker of clonal cell lineages in emerging neoplasia.

M. Horwitz, J. Salk, 2010, Seminars in cancer biology.