F. Sakurai

发表

Effects of erythrocytes and serum proteins on lung accumulation of lipoplexes containing cholesterol or DOPE as a helper lipid in the single-pass rat lung perfusion system.

M. Hashida, F. Yamashita, F. Sakurai, 2001, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Innate immune response induced by gene delivery vectors.

Shinsaku Nakagawa, Hiroyuki Mizuguchi, S. Nakagawa, 2008, International journal of pharmaceutics.

Interaction between DNA–cationic liposome complexes and erythrocytes is an important factor in systemic gene transfer via the intravenous route in mice: the role of the neutral helper lipid

M. Hashida, F. Yamashita, F. Sakurai, 2001, Gene Therapy.

Effect of DNA/liposome mixing ratio on the physicochemical characteristics, cellular uptake and intracellular trafficking of plasmid DNA/cationic liposome complexes and subsequent gene expression.

M. Hashida, F. Yamashita, F. Sakurai, 2000, Journal of controlled release : official journal of the Controlled Release Society.

Effects of positive charge density on the liposomal surface on disposition kinetics of liposomes in rats

F. Sakurai, H. Aoki, K. Fuji, 1997 .

Hexon-specific PEGylated adenovirus vectors utilizing avidin-biotin interaction.

S. Nakagawa, H. Mizuguchi, F. Sakurai, 2011, Biomaterials.

Approaches to improving the kinetics of adenovirus-delivered genes and gene products.

H. Mizuguchi, T. Hayakawa, F. Sakurai, 2005, Advanced drug delivery reviews.

Type I Interferons Impede Short Hairpin RNA-Mediated RNAi via Inhibition of Dicer-Mediated Processing to Small Interfering RNA

H. Mizuguchi, F. Sakurai, M. Tachibana, 2016, Molecular therapy. Nucleic acids.

Improving adenovirus vector-mediated RNAi efficiency by lacking the expression of virus-associated RNAs.

H. Mizuguchi, F. Sakurai, K. Katayama, 2013, Virus research.

An effective gene-knockdown using multiple shRNA-expressing adenovirus vectors.

Masahide Takahashi, H. Mizuguchi, Takuya Kato, 2011, Journal of controlled release : official journal of the Controlled Release Society.

Optimal human iPS cell culture method for efficient hepatic differentiation.

H. Mizuguchi, T. Yamashita, F. Sakurai, 2018, Differentiation; research in biological diversity.

Modeling of drug-mediated CYP3A4 induction by using human iPS cell-derived enterocyte-like cells.

H. Mizuguchi, F. Sakurai, M. Tachibana, 2016, Biochemical and biophysical research communications.

Detection of circulating tumor cells in cervical cancer using a conditionally replicative adenovirus targeting telomerase‐positive cells

T. Sasagawa, S. Kyo, M. Takakura, 2017, Cancer science.

Fiber-modified adenovirus vectors mediate efficient gene transfer into undifferentiated and adipogenic-differentiated human mesenchymal stem cells.

H. Mizuguchi, T. Hayakawa, F. Sakurai, 2005, Biochemical and biophysical research communications.

Hepatic maturation of human iPS cell-derived hepatocyte-like cells by ATF5, c/EBPα, and PROX1 transduction.

H. Mizuguchi, F. Sakurai, M. Tachibana, 2016, Biochemical and biophysical research communications.

Adenovirus vector-based vaccine for infectious diseases

H. Mizuguchi, F. Sakurai, M. Tachibana, 2021, Drug Metabolism and Pharmacokinetics.

Induction of type I interferon by adenovirus-encoded small RNAs

K. Ishii, S. Akira, H. Mizuguchi, 2010, Proceedings of the National Academy of Sciences.

Tumor-specific delivery of biologics by a novel T-cell line HOZOT

T. Fujiwara, H. Mizuguchi, Y. Umeda, 2016, Scientific Reports.

Reduction of Natural Adenovirus Tropism to Mouse Liverby Fiber-Shaft Exchange in Combination with both CAR- andαv Integrin-BindingAblation

H. Mizuguchi, T. Hayakawa, F. Sakurai, 2003, Journal of Virology.

Adenovirus vector-mediated doxycycline-inducible RNA interference.

S. Nakagawa, T. Mayumi, H. Mizuguchi, 2004, Human gene therapy.

A TGFβ Signaling Inhibitor, SB431542, Inhibits Reovirus-mediated Lysis of Human Hepatocellular Carcinoma Cells in a TGFβ-independent Manner

H. Mizuguchi, F. Sakurai, I. Ishigami, 2021, AntiCancer Research.

Human induced-pluripotent stem cell-derived hepatocyte-like cells as an in vitro model of human hepatitis B virus infection

H. Mizuguchi, Yasuhito Tanaka, T. Wakita, 2017, Scientific Reports.

Systemically Administered Reovirus-Induced Downregulation of Hypoxia Inducible Factor-1α in Subcutaneous Tumors

H. Mizuguchi, F. Sakurai, T. Hotani, 2018, Molecular therapy oncolytics.

A dopamine antagonist, domperidone enhances the replication of an oncolytic adenovirus in human tumour cells.

H. Mizuguchi, F. Sakurai, Kosuke Takayama, 2022, The Journal of general virology.

Optimization of an E1A Gene Expression Cassette in an Oncolytic Adenovirus for Efficient Tumor Cell Killing Activity

H. Mizuguchi, F. Sakurai, Kosuke Takayama, 2021, AntiCancer Research.

Development of a Novel Oncolytic Adenovirus Expressing a Short-hairpin RNA Against Cullin 4A

T. Fujiwara, H. Mizuguchi, F. Sakurai, 2020, AntiCancer Research.

LY341495, an mGluR2/3 Antagonist, Regulates the Immunosuppressive Function of Myeloid-Derived Suppressor Cells and Inhibits Melanoma Tumor Growth.

H. Mizuguchi, F. Sakurai, Y. Ago, 2018, Biological & pharmaceutical bulletin.

Generation of safe and therapeutically effective human induced pluripotent stem cell‐derived hepatocyte‐like cells for regenerative medicine

O. Ohara, K. Sekiguchi, T. Morio, 2017, Hepatology communications.

Reovirus double-stranded RNA genomes and polyI:C induce down-regulation of hypoxia-inducible factor 1α.

H. Mizuguchi, F. Sakurai, M. Tachibana, 2015, Biochemical and biophysical research communications.

Tumor‐targeted fluorescence labeling systems for cancer diagnosis and treatment

Takeshi Imamura, Hisataka Kobayashi, T. Fujiwara, 2022, Cancer science.

Adenovirus serotype 35 vector-mediated transduction following direct administration into organs of nonhuman primates

H. Mizuguchi, T. Hayakawa, K. Terao, 2009, Gene Therapy.

Prediction of interindividual differences in hepatic functions and drug sensitivity by using human iPS-derived hepatocytes

K. Harada, H. Mizuguchi, E. Noguchi, 2014, Proceedings of the National Academy of Sciences.

A targeted adenovirus vector displaying a human fibronectin type III domain-based monobody in a fiber protein.

H. Mizuguchi, F. Sakurai, K. Katayama, 2013, Biomaterials.

Adenovirus Vector–Induced IL-6 Promotes Leaky Adenoviral Gene Expression, Leading to Acute Hepatotoxicity

H. Mizuguchi, Y. Fujio, F. Sakurai, 2020, The Journal of Immunology.

Intramuscular DNA immunization with in vivo electroporation induces antigen-specific cellular and humoral immune responses in both systemic and gut-mucosal compartments.

H. Mizuguchi, F. Sakurai, K. Katayama, 2012, Vaccine.

Type-I IFN signaling is required for the induction of antigen-specific CD8(+) T cell responses by adenovirus vector vaccine in the gut-mucosa.

K. Ishii, S. Akira, H. Mizuguchi, 2012, Biochemical and biophysical research communications.

Enhanced in vivo gene transfer into the placenta using RGD fiber-mutant adenovirus vector.

S. Nakagawa, H. Mizuguchi, T. Nakanishi, 2011, Biomaterials.

Transduction Properties of an Adenovirus Vector Containing Sequences Complementary to a Liver-Specific microRNA, miR-122a, in the 3'-Untranslated Region of the E4 Gene in Human Hepatocytes from Chimeric Mice with Humanized Liver.

K. Chayama, H. Mizuguchi, F. Sakurai, 2021, Biological & pharmaceutical bulletin.

Adenoviral Expression of Suppressor of Cytokine Signaling-1 Reduces Adenovirus Vector-Induced Innate Immune Responses1

S. Nakagawa, H. Mizuguchi, F. Sakurai, 2008, The Journal of Immunology.

Transplantation of a human iPSC-derived hepatocyte sheet increases survival in mice with acute liver failure.

H. Mizuguchi, F. Sakurai, K. Kawabata, 2016, Journal of hepatology.

Fiber-Modified Adenovirus Vectors Decrease Liver Toxicity through Reduced IL-6 Production1

H. Mizuguchi, T. Hayakawa, F. Sakurai, 2007, The Journal of Immunology.

Effective tumor targeted gene transfer using PEGylated adenovirus vector via systemic administration.

Y. Yoshioka, Y. Tsutsumi, S. Nakagawa, 2007, Journal of controlled release : official journal of the Controlled Release Society.

Enhancement of survival rate by human iPSC-derived hepatocyte sheet transplantation in acute liver failure mice

H. Mizuguchi, F. Sakurai, K. Kawabata, 2016 .

Adenovirus Vector-Derived VA-RNA-Mediated Innate Immune Responses

H. Mizuguchi, F. Sakurai, K. Katayama, 2011, Pharmaceutics.

Role of MyD88 and TLR9 in the innate immune response elicited by serotype 5 adenoviral vectors.

H. Mizuguchi, N. Okada, K. Yamanishi, 2007, Human gene therapy.

T Helper 17 Promotes Induction of Antigen-Specific Gut-Mucosal Cytotoxic T Lymphocytes following Adenovirus Vector Vaccination

K. Ishii, S. Akira, H. Mizuguchi, 2017, Front. Immunol..

The Early Activation of CD8+ T Cells Is Dependent on Type I IFN Signaling following Intramuscular Vaccination of Adenovirus Vector

K. Ishii, S. Akira, H. Mizuguchi, 2014, BioMed research international.

Efficient gene transfer into murine pancreatic islets using adenovirus vectors.

H. Mizuguchi, F. Sakurai, K. Kawabata, 2007, Journal of controlled release : official journal of the Controlled Release Society.

A Flow Cytometry-Based Method to Determine the Titer of Adenoviruses Expressing an Extraneous Gene.

H. Mizuguchi, F. Sakurai, Y. Urata, 2018, Biological & pharmaceutical bulletin.

Gene delivery into stem cells by modified adenovirus vectors

H. Mizuguchi, F. Sakurai, K. Kawabata, 2007 .

Evaluation of Transduction Properties of an Adenovirus Vector in Neonatal Mice

H. Mizuguchi, F. Sakurai, K. Ohashi, 2015, BioMed research international.

Dicer functions as an antiviral system against human adenoviruses via cleavage of adenovirus-encoded noncoding RNA

H. Mizuguchi, F. Sakurai, M. Tachibana, 2016, Scientific Reports.

Suppressive effects of sugar-modified cationic liposome/NF-kappaB decoy complexes on adenovirus vector-induced innate immune responses.

S. Kawakami, M. Hashida, H. Mizuguchi, 2009, Journal of controlled release : official journal of the Controlled Release Society.

Efficient Gene Transduction of Dispersed Islet Cells in Culture Using Fiber-Modified Adenoviral Vectors.

T. Okano, H. Mizuguchi, F. Sakurai, 2015, Cell medicine.

The role of tissue macrophages in the induction of proinflammatory cytokine production following intravenous injection of lipoplexes

M. Hashida, F. Yamashita, F. Sakurai, 2002, Gene Therapy.

Asymmetric profiles of infection and innate immunological responses in human iPS cell-derived small intestinal epithelial-like cell monolayers following infection with mammalian reovirus.

H. Mizuguchi, F. Sakurai, Kazuo Takayama, 2021, Virus research.

Optimization of adenovirus serotype 35 vectors for efficient transduction in human hematopoietic progenitors: comparison of promoter activities

H. Mizuguchi, T. Hayakawa, F. Sakurai, 2005, Gene Therapy.

NF-κB promotes leaky expression of adenovirus genes in a replication-incompetent adenovirus vector

H. Mizuguchi, F. Sakurai, M. Tachibana, 2016, Scientific Reports.

Development of fiber-substituted adenovirus vectors containing foreign peptides in the adenovirus serotype 35 fiber knob

H. Mizuguchi, K. Yamanishi, F. Sakurai, 2009, Gene Therapy.

Laminin 411 and 511 promote the cholangiocyte differentiation of human induced pluripotent stem cells.

K. Sekiguchi, H. Mizuguchi, F. Sakurai, 2016, Biochemical and biophysical research communications.

Modification of pIX or hexon based on fiberless Ad vectors is not effective for targeted Ad vectors.

S. Nakagawa, H. Mizuguchi, F. Sakurai, 2008, Journal of Controlled Release.

Fiber-modified adenovirus vectors containing the TAT peptide derived from HIV-1 in the fiber knob have efficient gene transfer activity

S. Nakagawa, H. Okamoto, H. Mizuguchi, 2007, Gene Therapy.

Characterization of capsid-modified adenovirus vectors containing heterologous peptides in the fiber knob, protein IX, or hexon

S. Nakagawa, H. Mizuguchi, T. Hayakawa, 2007, Gene Therapy.

Long-Term Self-Renewal of Human ES/iPS-Derived Hepatoblast-like Cells on Human Laminin 111-Coated Dishes

H. Mizuguchi, T. Hayakawa, F. Sakurai, 2013, Stem cell reports.

Billion-scale production of hepatocyte-like cells from human induced pluripotent stem cells.

H. Mizuguchi, T. Yamashita, F. Sakurai, 2018, Biochemical and biophysical research communications.

Efficient gene transfer into human CD34+ cells by an adenovirus type 35 vector

H. Mizuguchi, T. Hayakawa, F. Sakurai, 2003, Gene Therapy.

Efficient osteoblast differentiation from mouse bone marrow stromal cells with polylysin-modified adenovirus vectors.

H. Mizuguchi, T. Hayakawa, K. Yamanishi, 2009, Biochemical and biophysical research communications.

Liver-specific overexpression of lipoprotein lipase improves glucose metabolism in high-fat diet-fed mice

Yuka Egusa, H. Mizuguchi, F. Sakurai, 2022, PloS one.

Development of recombinant viruses containing microRNA-regulated gene expression system

H. Mizuguchi, F. Sakurai, K. Kawabata, 2009 .

TANK-binding kinase 1-dependent or -independent signaling elicits the cell-type-specific innate immune responses induced by the adenovirus vector.

K. Ishii, S. Akira, H. Mizuguchi, 2016, International immunology.

Evaluation of the Immune Response After Administration of Plasmid DNA-Non-viral Vector Complexes

M. Hashida, F. Sakurai, Y. Takakura, 2005 .

Enhanced Oncolytic Activities of the Telomerase-Specific Replication-Competent Adenovirus Expressing Short-Hairpin RNA against Dicer

T. Fujiwara, H. Mizuguchi, F. Sakurai, 2016, Molecular Cancer Therapeutics.

Enhanced transduction efficiency of fiber-substituted adenovirus vectors by the incorporation of RGD peptides in two distinct regions of the adenovirus serotype 35 fiber knob.

H. Mizuguchi, F. Sakurai, K. Katayama, 2011, Virus research.

[Characterization of adenovirus serotype 35 vectors using genetically modified animals and non-human primates].

H. Mizuguchi, F. Sakurai, K. Kawabata, 2006, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

Expression of coxsackie and adenovirus receptor reduces the lung metastatic potential of murine tumor cells

H. Mizuguchi, F. Sakurai, K. Kawabata, 2007, International journal of cancer.

Antibodies against adenovirus fiber and penton base proteins inhibit adenovirus vector-mediated transduction in the liver following systemic administration

H. Mizuguchi, H. Kamada, F. Sakurai, 2018, Scientific Reports.

Development of a recombinant adenovirus vector production system free of replication-competent adenovirus by utilizing a packaging size limit of the viral genome.

K. Yagi, H. Mizuguchi, T. Hayakawa, 2011, Virus research.

[Development of improved adenovirus vectors and transduction into neural cells].

H. Mizuguchi, F. Sakurai, K. Katayama, 2011, Nihon yakurigaku zasshi. Folia pharmacologica Japonica.

Development of an adenovirus vector lacking the expression of virus-associated RNAs.

H. Mizuguchi, H. Miyoshi, F. Sakurai, 2011, Journal of controlled release : official journal of the Controlled Release Society.

Downregulation of human CD46 by adenovirus serotype 35 vectors

H. Mizuguchi, T. Hayakawa, F. Sakurai, 2007, Gene Therapy.

Characterization of in vitro and in vivo gene transfer properties of adenovirus serotype 35 vector.

H. Mizuguchi, T. Hayakawa, F. Sakurai, 2003, Molecular therapy : the journal of the American Society of Gene Therapy.

Efficient generation of functional hepatocytes from human embryonic stem cells and induced pluripotent stem cells by HNF4α transduction.

Takao Hayakawa, Hiroyuki Mizuguchi, H. Mizuguchi, 2012, Molecular therapy : the journal of the American Society of Gene Therapy.

Efficient Generation of Functional Hepatocytes From Human Embryonic Stem Cells and Induced Pluripotent Stem Cells by HNF4α Transduction.

Takao Hayakawa, Hiroyuki Mizuguchi, H. Mizuguchi, 2012, Molecular therapy : the journal of the American Society of Gene Therapy.

Efficient Generation of Hepatoblasts From Human ES Cells and iPS Cells by Transient Overexpression of Homeobox Gene HEX

Hidenori Akutsu, Takao Hayakawa, Akihiro Umezawa, 2010, Molecular therapy : the journal of the American Society of Gene Therapy.

miR-27b-mediated suppression of aquaporin-11 expression in hepatocytes reduces HCV genomic RNA levels but not viral titers

N. Sakamoto, H. Mizuguchi, T. Imaizumi, 2019, Virology Journal.

Use of human hepatocyte-like cells derived from induced pluripotent stem cells as a model for hepatocytes in hepatitis C virus infection.

Yoshiharu Matsuura, Hiroyuki Mizuguchi, Masuo Kondoh, 2011, Biochemical and biophysical research communications.

miR-122a-regulated expression of a suicide gene prevents hepatotoxicity without altering antitumor effects in suicide gene therapy.

K. Yagi, H. Mizuguchi, F. Sakurai, 2008, Molecular therapy : the journal of the American Society of Gene Therapy.

miR-122a-Regulated Expression of a Suicide Gene Prevents Hepatotoxicity Without Altering Antitumor Effects in Suicide Gene Therapy.

K. Yagi, H. Mizuguchi, F. Sakurai, 2008, Molecular therapy : the journal of the American Society of Gene Therapy.

MicroRNA miR-27 Inhibits Adenovirus Infection by Suppressing the Expression of SNAP25 and TXN2

H. Mizuguchi, F. Sakurai, M. Tachibana, 2017, Journal of Virology.

Suppression of leaky expression of adenovirus genes by insertion of microRNA-targeted sequences in the replication-incompetent adenovirus vector genome

H. Mizuguchi, F. Sakurai, K. Katayama, 2014, Molecular therapy. Methods & clinical development.

A mammalian mirtron miR-1224 promotes tube-formation of human primary endothelial cells by targeting anti-angiogenic factor epsin2

H. Mizuguchi, F. Sakurai, K. Kawabata, 2017, Scientific Reports.

MicroRNA-regulated transgene expression systems for gene therapy and virotherapy.

H. Mizuguchi, F. Sakurai, K. Katayama, 2011, Frontiers in bioscience.

Optimization of a microRNA expression vector for function analysis of microRNA.

N. Seki, H. Mizuguchi, F. Sakurai, 2011, Journal of controlled release : official journal of the Controlled Release Society.

Activation of LDL receptor expression by small RNAs complementary to a noncoding transcript that overlaps the LDLR promoter.

D. Corey, M. Manoharan, S. Elbashir, 2010, Chemistry & biology.

Neonatal Gene Therapy for Hemophilia B by a Novel Adenovirus Vector Showing Reduced Leaky Expression of Viral Genes

H. Mizuguchi, F. Sakurai, K. Ohashi, 2017, Molecular therapy. Methods & clinical development.

Efficient adenovirus vector‐mediated PPAR gamma gene transfer into mouse embryoid bodies promotes adipocyte differentiation

H. Mizuguchi, K. Yamanishi, F. Sakurai, 2008, The journal of gene medicine.

Hepatocyte Nuclear Factor 4 Alpha Promotes Definitive Endoderm Differentiation from Human Induced Pluripotent Stem Cells

H. Mizuguchi, F. Sakurai, M. Tachibana, 2017, Stem Cell Reviews and Reports.

Nanaomycin A treatment promotes hepatoblast differentiation from human iPS cells

H. Mizuguchi, F. Sakurai, Kazuo Takayama, 2018 .

Efficient Adipocyte and Osteoblast Differentiation from Mouse Induced Pluripotent Stem Cells by Adenoviral Transduction

H. Mizuguchi, T. Hayakawa, K. Yamanishi, 2009, Stem cells.

Direct conversion of human fibroblasts into hepatocyte-like cells by ATF5, PROX1, FOXA2, FOXA3, and HNF4A transduction

H. Mizuguchi, F. Sakurai, Kazuo Takayama, 2017, Scientific Reports.

Generation of a bile salt export pump deficiency model using patient-specific induced pluripotent stem cell-derived hepatocyte-like cells

K. Harada, H. Mizuguchi, E. Noguchi, 2017, Scientific Reports.

Generation of enterocyte-like cells from human induced pluripotent stem cells for drug absorption and metabolism studies in human small intestine

H. Mizuguchi, F. Sakurai, K. Kawabata, 2015, Scientific Reports.

Efficient generation of adenovirus vectors carrying the Clustered regularly interspaced short palindromic repeat (CRISPR)-CRISPR associated proteins (Cas)12a system by suppressing Cas12a expression in packaging cells.

H. Mizuguchi, F. Sakurai, E. Sakai, 2019, Journal of biotechnology.

Generation of the Adenovirus Vector-Mediated CRISPR/Cpf1 System and the Application for Primary Human Hepatocytes Prepared from Humanized Mice with Chimeric Liver.

H. Mizuguchi, F. Sakurai, E. Sakai, 2018, Biological & pharmaceutical bulletin.

Efficient and Directive Generation of Two Distinct Endoderm Lineages from Human ESCs and iPSCs by Differentiation Stage-Specific SOX17 Transduction

H. Mizuguchi, T. Hayakawa, F. Sakurai, 2011, PloS one.

Upregulation of RECK gene expression by small double-stranded RNA targeting the promoter region

H. Mizuguchi, F. Sakurai, M. Tachibana, 2014, Cancer Gene Therapy.

Ablation of IL-17A leads to severe colitis in IL-10-deficient mice: implications of myeloid-derived suppressor cells and NO production

H. Mizuguchi, O. Kaminuma, F. Sakurai, 2019, International immunology.

Efficient antitumor effects of carrier cells loaded with a fiber-substituted conditionally replicating adenovirus on CAR-negative tumor cells

H. Mizuguchi, M. Tagawa, M. Kawabata, 2011, Cancer Gene Therapy.

Efficient Generation of Small Intestinal Epithelial-like Cells from Human iPSCs for Drug Absorption and Metabolism Studies

K. Harada, H. Mizuguchi, F. Sakurai, 2018, Stem cell reports.

Rapid construction of small interfering RNA-expressing adenoviral vectors on the basis of direct cloning of short hairpin RNA-coding DNAs.

Takao Hayakawa, Hiroyuki Mizuguchi, H. Mizuguchi, 2006, Human gene therapy.

Adenovirus serotype 35 vector-mediated transduction into human CD46-transgenic mice

M. Okabe, H. Mizuguchi, T. Hayakawa, 2006, Gene Therapy.

Suppression of Oncolytic Adenovirus-Mediated Hepatotoxicity by Liver-Specific Inhibition of NF-κB

N. Kato, T. Fujiwara, H. Mizuguchi, 2017, Molecular therapy oncolytics.

Correlation between adenovirus-neutralizing antibody titer and adenovirus vector-mediated transduction efficiency following intratumoral injection.

H. Mizuguchi, F. Sakurai, M. Tachibana, 2012, Anticancer research.

Transduction properties of adenovirus serotype 35 vectors after intravenous administration into nonhuman primates.

H. Mizuguchi, T. Hayakawa, K. Terao, 2008, Molecular therapy : the journal of the American Society of Gene Therapy.

The short consensus repeats 1 and 2, not the cytoplasmic domain, of human CD46 are crucial for infection of subgroup B adenovirus serotype 35.

H. Mizuguchi, T. Hayakawa, N. Okada, 2006, Journal of controlled release : official journal of the Controlled Release Society.

Modified adenoviral vectors ablated for coxsackievirus-adenovirus receptor, alphav integrin, and heparan sulfate binding reduce in vivo tissue transduction and toxicity.

H. Mizuguchi, T. Hayakawa, F. Sakurai, 2006, Human gene therapy.

Promotion of hematopoietic differentiation from mouse induced pluripotent stem cells by transient HoxB4 transduction.

H. Mizuguchi, T. Hayakawa, F. Sakurai, 2012, Stem cell research.

Proteolytic Disassembly of Viral Outer Capsid Proteins Is Crucial for Reovirus-Mediated Type-I Interferon Induction in Both Reovirus-Susceptible and Reovirus-Refractory Tumor Cells

H. Mizuguchi, F. Sakurai, M. Tachibana, 2015, BioMed research international.

Adenovirus vector-mediated gene transfer into stem cells.

H. Mizuguchi, T. Hayakawa, F. Sakurai, 2006, Molecular pharmaceutics.

Efficient gene transfer into mouse embryonic stem cells with adenovirus vectors.

H. Mizuguchi, T. Hayakawa, F. Sakurai, 2005, Molecular therapy : the journal of the American Society of Gene Therapy.

Sensitive detection of viable circulating tumor cells using a novel conditionally telomerase-selective replicating adenovirus in non-small cell lung cancer patients

Kenji Suzuki, H. Mizuguchi, Kazuhisa Takahashi, 2017, Oncotarget.

The infectivity of progeny adenovirus in the presence of neutralizing antibody

H. Mizuguchi, F. Sakurai, M. Fujii, 2021, The Journal of general virology.

Factors involved in the maturation of murine dendritic cells transduced with adenoviral vector variants.

S. Nakagawa, H. Mizuguchi, T. Fujita, 2008, Virology.

[Development of a replication-incompetent adenovirus vector derived from subgroup B adenovirus serotype 35].

F. Sakurai, 2008, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

Development and evaluation of a novel gene delivery vehicle composed of adenovirus serotype 35.

F. Sakurai, 2008, Biological & pharmaceutical bulletin.

Interaction of penton base Arg-Gly-Asp motifs with integrins is crucial for adenovirus serotype 35 vector transduction in human hematopoietic cells

H. Mizuguchi, T. Hayakawa, T. Fujita, 2007, Gene Therapy.

Highly efficient biallelic genome editing of human ES/iPS cells using a CRISPR/Cas9 or TALEN system

H. Mizuguchi, Takashi Yamamoto, F. Sakurai, 2017, Nucleic acids research.

Antibodies against adenovirus fiber and penton base proteins inhibit adenovirus vector-mediated transduction in the liver following systemic administration

H. Mizuguchi, H. Kamada, F. Sakurai, 2018, Scientific Reports.

Oncolytic Reovirus Inhibits Immunosuppressive Activity of Myeloid-Derived Suppressor Cells in a TLR3-Dependent Manner

K. Ishii, S. Akira, H. Mizuguchi, 2018, The Journal of Immunology.

Transduction Properties of Adenovirus Serotype 35 Vectors After Intravenous Administration Into Nonhuman Primates.

Takao Hayakawa, Hiroaki Shibata, Hiroyuki Mizuguchi, 2008, Molecular therapy : the journal of the American Society of Gene Therapy.

Clonal Rett Syndrome cell lines to test compounds for activation of wild-type MeCP2 expression.

D. Corey, F. Sakurai, Dongbo Yu, 2011, Bioorganic & medicinal chemistry letters.

Enhanced Safety Profiles of the Telomerase-Specific Replication- Competent Adenovirus by Incorporation of Normal Cell-Specific microRNA-Targeted Sequences

T. Fujiwara, H. Mizuguchi, T. Hayakawa, 2011, Clinical Cancer Research.

Modified method for differentiation of myeloid-derived suppressor cells in vitro enhances immunosuppressive ability via glutathione metabolism

H. Mizuguchi, D. Okuzaki, F. Sakurai, 2022, Biochemistry and biophysics reports.

Tight positive regulation of transgene expression by a single adenovirus vector containing the rtTA and tTS expression cassettes in separate genome regions.

T. Mayumi, H. Mizuguchi, T. Hayakawa, 2003, Human gene therapy.

Efficient detection of human circulating tumor cells without significant production of false-positive cells by a novel conditionally replicating adenovirus

T. Fujiwara, H. Mizuguchi, F. Sakurai, 2016, Molecular therapy. Methods & clinical development.

Efficient gene delivery in human and rodent mast cells using adenovirus vectors.

H. Mizuguchi, F. Sakurai, K. Kawabata, 2008, Journal of controlled release : official journal of the Controlled Release Society.

Efficient regulation of gene expression using self-contained fiber-modified adenovirus vectors containing the tet-off system.

H. Mizuguchi, T. Hayakawa, F. Sakurai, 2005, Journal of controlled release : official journal of the Controlled Release Society.

Oncolytic adenovirus serotype 35 mediated tumor growth suppression via efficient activation and tumor infiltration of natural killer cells

H. Mizuguchi, F. Sakurai, R. Ono, 2022, bioRxiv.

Adenovirus vectors composed of subgroup B adenoviruses.

H. Mizuguchi, F. Sakurai, K. Kawabata, 2007, Current gene therapy.

Further reduction in adenovirus vector-mediated liver transduction without largely affecting transgene expression in target organ by exploiting microrna-mediated regulation and the Cre-loxP recombination system.

H. Mizuguchi, F. Sakurai, K. Katayama, 2012, Molecular pharmaceutics.

Development of mice exhibiting hepatic microsomal activity of human CYP3A4 comparable to that in human liver microsomes by intravenous administration of an adenovirus vector expressing human CYP3A4.

H. Mizuguchi, F. Sakurai, T. Yokoi, 2014, Drug metabolism and pharmacokinetics.

Quantitative analysis of the leaky expression of adenovirus genes in cells transduced with a replication-incompetent adenovirus vector.

H. Mizuguchi, F. Sakurai, K. Katayama, 2011, Molecular pharmaceutics.

Vector-Induced Innate Immune Responses Cytokine Signaling-1 Reduces Adenovirus Adenoviral Expression of Suppressor of

H. Mizuguchi, F. Sakurai, K. Kawabata, 2010 .

Therapeutic effect of intravenous delivery of lipoplexes containing the interferon-β gene and poly I: poly C in a murine lung metastasis model

M. Hashida, F. Yamashita, F. Sakurai, 2003, Cancer Gene Therapy.

Generation of metabolically functioning hepatocytes from human pluripotent stem cells by FOXA2 and HNF1α transduction.

H. Mizuguchi, T. Hayakawa, F. Sakurai, 2012, Journal of hepatology.

The promotion of hepatic maturation of human pluripotent stem cells in 3D co-culture using type I collagen and Swiss 3T3 cell sheets.

Takao Hayakawa, Hiroyuki Mizuguchi, H. Mizuguchi, 2012, Biomaterials.

3D spheroid culture of hESC/hiPSC-derived hepatocyte-like cells for drug toxicity testing.

Takao Hayakawa, Hiroyuki Mizuguchi, K. Kanda, 2013, Biomaterials.

Prevention of hepatic ischemia-reperfusion injury by pre-administration of catalase-expressing adenovirus vectors.

K. Yagi, H. Mizuguchi, F. Sakurai, 2010, Journal of controlled release : official journal of the Controlled Release Society.

Enrichment of high-functioning human iPS cell-derived hepatocyte-like cells for pharmaceutical research.

K. Sekiguchi, H. Mizuguchi, F. Sakurai, 2018, Biomaterials.

miR-27b antagonizes BMP signaling in early differentiation of human induced pluripotent stem cells

H. Mizuguchi, F. Sakurai, E. Sakai, 2021, Scientific Reports.

HHEX Promotes Hepatic-Lineage Specification through the Negative Regulation of Eomesodermin

H. Mizuguchi, F. Sakurai, K. Katayama, 2014, PloS one.

Inhibition of CRISPR/Cas9-Mediated Genome Engineering by a Type I Interferon-Induced Reduction in Guide RNA Expression.

H. Mizuguchi, F. Sakurai, M. Tachibana, 2017, Biological & pharmaceutical bulletin.

A hexon-specific PEGylated adenovirus vector utilizing blood coagulation factor X.

S. Nakagawa, H. Mizuguchi, F. Sakurai, 2012, Biomaterials.

CCAAT/enhancer binding protein-mediated regulation of TGFβ receptor 2 expression determines the hepatoblast fate decision

T. Okano, H. Mizuguchi, T. Hayakawa, 2014, Development.

Inhibition of Lnk in mouse induced pluripotent stem cells promotes hematopoietic cell generation.

H. Mizuguchi, S. Takaki, F. Sakurai, 2012, Stem cells and development.

Adenovirus vector-mediated efficient transduction into human embryonic and induced pluripotent stem cells.

H. Mizuguchi, T. Hayakawa, F. Sakurai, 2010, Cellular reprogramming.

Adenovirus Vector With ADP Gene Induces Cytopathic Effects in HEK293 Cells Without Significant Elevation of Virus Titers

H. Mizuguchi, F. Sakurai, Fumitaka Nishimae, 2022, AntiCancer Research.

ZFAND3 Overexpression in the Mouse Liver Improves Glucose Tolerance and Hepatic Insulin Resistance.

H. Mizuguchi, F. Sakurai, T. Nishinaka, 2021, Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association.

Efficient antitumor effects of a novel oncolytic adenovirus fully composed of species B adenovirus serotype 35

H. Mizuguchi, F. Sakurai, Kosuke Takayama, 2021, Molecular therapy oncolytics.

A MicroRNA Derived from Adenovirus Virus-Associated RNAII Promotes Virus Infection via Posttranscriptional Gene Silencing

H. Mizuguchi, F. Sakurai, M. Tachibana, 2018, Journal of Virology.

Human ESC/iPSC-Derived Hepatocyte-like Cells Achieve Zone-Specific Hepatic Properties by Modulation of WNT Signaling.

H. Mizuguchi, F. Sakurai, M. Tachibana, 2017, Molecular therapy : the journal of the American Society of Gene Therapy.

Adenovirus vector-mediated macrophage erythroblast attacher (MAEA) overexpression in primary mouse hepatocytes attenuates hepatic gluconeogenesis

H. Mizuguchi, F. Sakurai, T. Nishinaka, 2017, Biochemistry and biophysics reports.

Identification of Adenovirus-Derived Cell-Penetrating Peptide.

H. Mizuguchi, F. Sakurai, M. Fujii, 2017, Biological & pharmaceutical bulletin.

Efficient Engraftment of Human Induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cells in uPA/SCID Mice by Overexpression of FNK, a Bcl-xLMutant Gene

H. Mizuguchi, Yasuhito Tanaka, F. Sakurai, 2015, Cell transplantation.

Title : Inhibition of Lnk in mouse induced pluripotent stem cells promotes hematopoietic cell generation Running title : The role of Lnk in hematopoietic differentiation

H. Mizuguchi, S. Takaki, F. Sakurai, 2012 .

Adenovirus serotype 35 vector-induced innate immune responses in dendritic cells derived from wild-type and human CD46-transgenic mice: Comparison with a fiber-substituted Ad vector containing fiber proteins of Ad serotype 35.

H. Mizuguchi, T. Hayakawa, F. Sakurai, 2010, Journal of controlled release : official journal of the Controlled Release Society.

Comparison of gene expression efficiency and innate immune response induced by Ad vector and lipoplex.

S. Nakagawa, H. Mizuguchi, F. Sakurai, 2007, Journal of controlled release : official journal of the Controlled Release Society.

Quantitative Analysis of Virus-associated RNAI Expression following Transduction with a Replication-incompetent Adenovirus Vector In Vitro and In Vivo

H. Mizuguchi, F. Sakurai, M. Tachibana, 2014 .

FGF signal is not required for hepatoblast differentiation of human iPS cells

H. Mizuguchi, F. Sakurai, Kazuo Takayama, 2019, Scientific Reports.

Hepatitis C virus-induced innate immune responses in human iPS cell-derived hepatocyte-like cells.

N. Sakamoto, H. Mizuguchi, T. Wakita, 2017, Virus research.

Pre-treatment of oncolytic reovirus improves tumor accumulation and intratumoral distribution of PEG-liposomes.

H. Mizuguchi, F. Sakurai, A. Kasai, 2023, Journal of controlled release : official journal of the Controlled Release Society.

Activity levels of cathepsins B and L in tumor cells are a biomarker for efficacy of reovirus-mediated tumor cell killing

H. Mizuguchi, F. Sakurai, M. Tachibana, 2015, Cancer Gene Therapy.

Clinical features of squamous cell lung cancer with anaplastic lymphoma kinase (ALK)-rearrangement: a retrospective analysis and review

H. Mizuguchi, Kazuhisa Takahashi, F. Sakurai, 2018, Oncotarget.

Direct conversion of human fibroblasts into hepatocyte-like cells by ATF5, PROX1, FOXA2, FOXA3, and HNF4A transduction

H. Mizuguchi, F. Sakurai, Kazuo Takayama, 2017, Scientific Reports.

A mammalian mirtron miR-1224 promotes tube-formation of human primary endothelial cells by targeting anti-angiogenic factor epsin2

H. Mizuguchi, F. Sakurai, K. Kawabata, 2017, Scientific Reports.

Cationic liposome-mediated delivery of reovirus enhances the tumor cell-killing efficiencies of reovirus in reovirus-resistant tumor cells.

H. Mizuguchi, F. Sakurai, M. Tachibana, 2017, International journal of pharmaceutics.

Oncolytic reovirus-mediated killing of mouse cancer-associated fibroblasts.

H. Mizuguchi, F. Sakurai, I. Ishigami, 2021, International journal of pharmaceutics.

miR-27b-mediated suppression of aquaporin-11 expression in hepatocytes reduces HCV genomic RNA levels but not viral titers

N. Sakamoto, H. Mizuguchi, T. Imaizumi, 2019, Virology Journal.

miR-27b targets MAIP1 to mediate lipid accumulation in cultured human and mouse hepatic cells

H. Mizuguchi, F. Sakurai, Eiko Sakai, 2023, Communications biology.

Effects of pre-existing anti-adenovirus antibodies on transgene expression levels and therapeutic efficacies of arming oncolytic adenovirus

H. Mizuguchi, F. Sakurai, Fumitaka Nishimae, 2022, Scientific reports.

Suppression of hepatitis C virus replicon by adenovirus vector-mediated expression of tough decoy RNA against miR-122a.

N. Sakamoto, K. Yagi, H. Mizuguchi, 2012, Virus research.

Human iPS Cell–based Liver-like Tissue Engineering at Extrahepatic Sites in Mice as a New Cell Therapy for Hemophilia B

H. Suemizu, H. Mizuguchi, F. Sakurai, 2018, Cell transplantation.

H. Mizuguchi, F. Sakurai, K. Katayama, 2012, Molecular pharmaceutics.

Activation of LDL receptor expression by small RNAs complementary to a noncoding transcript that overlaps the LDLR promoter.

D. Corey, M. Manoharan, F. Sakurai, 2010, Chemistry & biology.

Type-I IFN signaling is required for the induction of antigen-specific CD8(+) T cell responses by adenovirus vector vaccine in the gut-mucosa.

K. Ishii, S. Akira, H. Mizuguchi, 2012, Biochemical and biophysical research communications.

Novel conditionally replicating adenovirus-mediated efficient detection of circulating tumor cells in lung cancer patients

T. Yamashita, F. Sakurai, S. Togo, 2023, PLoS ONE.

3D spheroid culture of hESC/hiPSC-derived hepatocyte-like cells for drug toxicity testing.

K. Kanda, H. Mizuguchi, T. Hayakawa, 2013, Biomaterials.

FGF signal is not required for hepatoblast differentiation of human iPS cells

H. Mizuguchi, F. Sakurai, Kazuo Takayama, 2019, Scientific Reports.

Suppression of hepatitis C virus replicon by adenovirus vector-mediated expression of tough decoy RNA against miR-122a.

N. Sakamoto, K. Yagi, H. Mizuguchi, 2012, Virus research.

Identification of Adenovirus-Derived Cell-Penetrating Peptide.

H. Mizuguchi, F. Sakurai, M. Fujii, 2017, Biological & pharmaceutical bulletin.

Overexpression of lysophospholipid acyltransferase, LPLAT10/LPCAT4/LPEAT2, in the mouse liver increases glucose‐stimulated insulin secretion

F. Sakurai, T. Nishinaka, S. Michinaga, 2024, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Modeling of drug-mediated CYP3A4 induction by using human iPS cell-derived enterocyte-like cells.

H. Mizuguchi, F. Sakurai, M. Tachibana, 2016, Biochemical and biophysical research communications.

Factors involved in the maturation of murine dendritic cells transduced with adenoviral vector variants.

S. Nakagawa, H. Mizuguchi, T. Fujita, 2008, Virology.

Use of human hepatocyte-like cells derived from induced pluripotent stem cells as a model for hepatocytes in hepatitis C virus infection.

N. Sakamoto, K. Yagi, H. Mizuguchi, 2011, Biochemical and biophysical research communications.

Development of a recombinant adenovirus vector production system free of replication-competent adenovirus by utilizing a packaging size limit of the viral genome.

K. Yagi, H. Mizuguchi, T. Hayakawa, 2011, Virus research.