S. Mobashery

发表

Discoidin Domain Receptors: Unique Receptor Tyrosine Kinases in Collagen-mediated Signaling*

Paul H. Huang, R. Fridman, Malika Kumarasiri, 2013, The Journal of Biological Chemistry.

Kinetic mechanism of enterococcal aminoglycoside phosphotransferase 2"-Ib.

J. Zajicek, S. Mobashery, M. Tóth, 2007, Biochemistry.

Synthetic Peptidoglycan Motifs for Germination of Bacterial Spores

J. Dworkin, A. Oliver, Ishita M. Shah, 2010, Chembiochem : a European journal of chemical biology.

Endless Resistance. Endless Antibiotics?

S. Mobashery, J. Fisher, 2016, MedChemComm.

The Importance of a Critical Protonation State and the Fate of the Catalytic Steps in Class A β-Lactamases and Penicillin-binding Proteins*

S. Meroueh, T. Stemmler, D. Golemi-Kotra, 2004, Journal of Biological Chemistry.

An antibiotic-resistance enzyme from a deep-sea bacterium.

S. Mobashery, M. Tóth, Clyde A. Smith, 2010, Journal of the American Chemical Society.

Mechanistic Basis for the Action of New Cephalosporin Antibiotics Effective against Methicillin- and Vancomycin-resistant Staphylococcus aureus*

S. Mobashery, S. Vakulenko, Mijoon Lee, 2006, Journal of Biological Chemistry.

Structural aspects for evolution of beta-lactamases from penicillin-binding proteins.

Samy O Meroueh, Brian K Shoichet, B. Shoichet, 2003, Journal of the American Chemical Society.

Activation of progelatinase B (MMP-9) by gelatinase A (MMP-2).

R. Fridman, S. Mobashery, M. Tóth, 1995, Cancer research.

Kinetic Analysis of the Binding of Human Matrix Metalloproteinase-2 and -9 to Tissue Inhibitor of Metalloproteinase (TIMP)-1 and TIMP-2*

R. Fridman, S. Mobashery, S Mobashery, 1997, The Journal of Biological Chemistry.

Characterization of the Monomeric and Dimeric Forms of Latent and Active Matrix Metalloproteinase-9

L. Kotra, I. Massova, M. Bernardo, 2000, The Journal of Biological Chemistry.

Constructing and deconstructing the bacterial cell wall

S. Mobashery, J. Fisher, 2019, Protein science : a publication of the Protein Society.

Discovery of a New Class of Non-β-lactam Inhibitors of Penicillin-Binding Proteins with Gram-Positive Antibacterial Activity

M. Suckow, Malika Kumarasiri, Hualiang Pi, 2014, Journal of the American Chemical Society.

Molecular Basis and Phenotype of Methicillin Resistance in Staphylococcus aureus and Insights into New β-Lactams That Meet the Challenge

S. Mobashery, J. Fisher, Leticia I. Llarrull, 2009, Antimicrobial Agents and Chemotherapy.

The Basis for Resistance to β-Lactam Antibiotics by Penicillin-binding Protein 2a of Methicillin-resistant Staphylococcus aureus*

S. Mobashery, S. Vakulenko, Shahriar Mobashery, 2004, Journal of Biological Chemistry.

Revealing cell-surface intramolecular interactions in the BlaR1 protein of methicillin-resistant Staphylococcus aureus by NMR spectroscopy.

Jeffrey W. Peng, Thomas E Frederick, S. Mobashery, 2014, Biochemistry.

X-ray Structure of Catenated Lytic Transglycosylase SltB1.

David A. Dik, R. Molina, J. Hermoso, 2017, Biochemistry.

8.13 – Enzymology of Bacterial Resistance

S. Mobashery, J. Fisher, 2010 .

Recent advances in MMP inhibitor design

S. Mobashery, J. Fisher, Shahriar Mobashery, 2006, Cancer and Metastasis Reviews.

Structural insights into the bactericidal mechanism of human peptidoglycan recognition proteins

Q. Wang, R. Mariuzza, S. Mobashery, 2007, Proceedings of the National Academy of Sciences.

Effects of Asp-179 mutations in TEMpUC19 beta-lactamase on susceptibility to beta-lactams

S. Mobashery, M. Tóth, S. Vakulenko, 1995, Antimicrobial agents and chemotherapy.

Susceptibility of Methicillin-Resistant Staphylococcus aureus to Five Quinazolinone Antibacterials

S. Mobashery, Choonkeun Kim, S. Ceballos, 2019, Antimicrobial Agents and Chemotherapy.

Exolytic and endolytic turnover of peptidoglycan by lytic transglycosylase Slt of Pseudomonas aeruginosa

David A. Dik, C. Millán, J. Hermoso, 2018, Proceedings of the National Academy of Sciences.

β-Lactam antibiotics, β-lactamases and bacterial resistance

L. Kotra, S. Mobashery, 1998 .

Acceleration of diabetic wound healing using a novel protease–anti-protease combination therapy

M. Suckow, S. Mobashery, W. Wolter, 2015, Proceedings of the National Academy of Sciences.

Substrate Hydrolysis by Matrix Metalloproteinase-9*

J W Smith, Jeffrey W. Smith, S. Kridel, 2001, The Journal of Biological Chemistry.

β-Lactam Antibiotics

S. Mobashery, J. Fisher, S. Testero, 2010 .

Kinship and Diversification of Bacterial Penicillin-Binding Proteins and β-Lactamases

I. Massova, S. Mobashery, 1998, Antimicrobial Agents and Chemotherapy.

Penicillin-Binding Protein 5 of Escherichia coli

Malika Kumarasiri, S. Mobashery, J. Fisher, 2013 .

Structural Analysis of the Role of Pseudomonas aeruginosa Penicillin-Binding Protein 5 in β-Lactam Resistance

Malika Kumarasiri, S. Mobashery, M. Tóth, 2013, Antimicrobial Agents and Chemotherapy.

A Novel β-Lactamase Activity from a Penicillin-binding Protein of Treponema pallidum and Why Syphilis Is Still Treatable with Penicillin*

S. Mobashery, J. Cha, A. Ishiwata, 2004, Journal of Biological Chemistry.

6-(Hydroxyalkyl)penicillanates as Probes for Mechanisms of β-Lactamases

I. Massova, L. Mourey, J. Samama, 2000 .

Evidence for Structural Elasticity of Class A β-Lactamases in the Course of Catalytic Turnover of the Novel Cephalosporin Cefepime

I. Massova, S. Mobashery, S. Vakulenko, 1996 .

Nuances of Mechanisms and Their Implications for Evolution of the Versatile β-Lactamase Activity: From Biosynthetic Enzymes to Drug Resistance Factors

I. Massova, S. Mobashery, K. Miyashita, 1997 .

Investigation of the mechanism of the cell wall DD-carboxypeptidase reaction of penicillin-binding protein 5 of Escherichia coli by quantum mechanics/molecular mechanics calculations.

Samy O Meroueh, S. Meroueh, S. Mobashery, 2008, Journal of the American Chemical Society.

Reactions of the three AmpD enzymes of Pseudomonas aeruginosa.

S. Mobashery, Mijoon Lee, D. Hesek, 2013, Journal of the American Chemical Society.

High-resolution X-ray structure of an acyl-enzyme species for the class D OXA-10 beta-lactamase.

J. Samama, D. Golemi-Kotra, S. Mobashery, 2002, Journal of the American Chemical Society.

High-resolution X-ray structure of an acyl-enzyme species for the class D OXA-10, β-lactamase

J. Samama, D. Golemi-Kotra, S. Mobashery, 2002 .

Synthesis, Kinetic Characterization and Metabolism of Diastereomeric 2‐(1‐(4‐Phenoxyphenylsulfonyl)ethyl)thiiranes as Potent Gelatinase and MT1‐MMP Inhibitors

R. Fridman, A. Oliver, S. Mobashery, 2009, Chemical biology & drug design.

Resistance to beta-Lactam Antibiotics Mediated by beta-Lactamases: Structure, Mechanism, and Evolution

L. Kotra, S. Mobashery, J. Cha, 2007 .

The basis for resistance to beta-lactam antibiotics by penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus.

S. Mobashery, S. Vakulenko, C. Fuda, 2004, The Journal of biological chemistry.

Structure-based inhibitor design for reshaping bacterial morphology

Yan Lee, Kiran V. Mahasenan, S. Mobashery, 2022, Communications Biology.

Catalytic Cycle of Glycoside Hydrolase BglX from Pseudomonas aeruginosa and Its Implication in Biofilm Formation.

J. Hermoso, Kiran V. Mahasenan, S. Mobashery, 2019, ACS chemical biology.

Conformational Dynamics in Penicillin-Binding Protein 2a of Methicillin-Resistant Staphylococcus aureus, Allosteric Communication Network and Enablement of Catalysis.

R. Molina, J. Hermoso, Kiran V. Mahasenan, 2017, Journal of the American Chemical Society.

Three-dimensional QSAR analysis and design of new 1,2,4-oxadiazole antibacterials.

Malika Kumarasiri, Kiran V. Mahasenan, S. Mobashery, 2016, Bioorganic & medicinal chemistry letters.

Prostate cancer-associated membrane type 1-matrix metalloproteinase: a pivotal role in bone response and intraosseous tumor growth.

R. Vessella, R. Fridman, J. T. Trindade Filho, 2007, The American journal of pathology.

Structural and mechanistic aspects of evolution of beta-lactamases and penicillin-binding proteins.

I. Massova, S. Mobashery, 1999, Current pharmaceutical design.

Aminoglycosides modified by resistance enzymes display diminished binding to the bacterial ribosomal aminoacyl-tRNA site.

L. Kotra, S. Mobashery, C. Chow, 2002, Chemistry & biology.

Pharmacological Stabilization of Intracranial Aneurysms in Mice

S. Mobashery, T. Hashimoto, Kosuke Wada, 2012 .

Pharmacological Stabilization of Intracranial Aneurysms in Mice: A Feasibility Study

S. Mobashery, H. Makino, T. Hashimoto, 2012, Stroke.

A light-inactivated antibiotic.

Z. H. Li, S. Vakulenko, S. Mobashery, 2000, Journal of medicinal chemistry.

Discovery of Mechanism-Based Inactivators for Human Pancreatic Carboxypeptidase A from a Focused Synthetic Library.

F. Avilés, D. Reverter, I. Pallarès, 2017, ACS medicinal chemistry letters.

The X‐Ray Structure of Carboxypeptidase A Inhibited by a Thiirane Mechanism‐Based Inhibitor

F. Avilés, S. Mobashery, J. Vendrell, 2010, Chemical biology & drug design.

The crystal structure of the major pneumococcal autolysin LytA in complex with a large peptidoglycan fragment reveals the pivotal role of glycans for lytic activity

S. Mobashery, P. Mellroth, B. Henriques-Normark, 2016, Molecular microbiology.

Tackling antibiotic resistance

Timothy R. Walsh, Alexander Tomasz, Christopher M. Thomas, 2011, Nature Reviews Microbiology.

The β-Lactam Antibiotics: Their Future in the Face of Resistance

S. Mobashery, J. Fisher, Erika Leemans, 2014 .

Antibiotics as physiological stress inducers and bacterial response to the challenge.

D. Mazel, S. Mobashery, 2012, Current opinion in microbiology.

MT1-MMP shedding involves an ADAM and is independent of its localization in lipid rafts.

R. Fridman, A. Sohail, S. Mobashery, 2006, Biochemical and biophysical research communications.

Allosteric Inhibition of Bacterial Targets: An Opportunity for Discovery of Novel Antibacterial Classes

S. Mobashery, J. Fisher, Mayland Chang, 2017 .

Glycosylation at Asn211 Regulates the Activation State of the Discoidin Domain Receptor 1 (DDR1)*

Paul H. Huang, R. Fridman, Malika Kumarasiri, 2014, The Journal of Biological Chemistry.

Roles of Matrix Metalloproteinases in Flow-Induced Outward Vascular Remodeling

W. Young, A. Sakamoto, S. Mobashery, 2009, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

The Quinazolinone Allosteric Inhibitor of PBP 2a Synergizes with Piperacillin and Tazobactam against Methicillin-Resistant Staphylococcus aureus

J. Hermoso, Kiran V. Mahasenan, S. Mobashery, 2019, Antimicrobial Agents and Chemotherapy.

Muropeptide Binding and the X-ray Structure of the Effector Domain of the Transcriptional Regulator AmpR of Pseudomonas aeruginosa.

David A. Dik, L. Hellman, J. Hermoso, 2017, Journal of the American Chemical Society.

2007 Foundation Host-Guest Chemistry of the Peptidoglycan

S. Mobashery, J. Fisher, 2011 .

A Type VI secretion system delivers a cell-wall amidase to target bacterial competitors.

Haihua Liang, Min Wu, S. Mobashery, 2020, Molecular microbiology.

Metabolism of the Selective Matrix Metalloproteinase-9 Inhibitor (R)-ND-336.

S. Mobashery, J. Fisher, Mayland Chang, 2021, ACS pharmacology & translational science.

Elucidation of the Molecular Recognition of Bacterial Cell Wall by Modular Pneumococcal Phage Endolysin CPL-1*

J. García, N. Campillo, B. Monterroso, 2007, Journal of Biological Chemistry.

Extracellular proteases as targets for treatment of cancer metastases.

R. Fridman, S. Mobashery, Mijoon Lee, 2004, Chemical Society reviews.

Regiospecific syntheses of 6alpha-(1R-Hydroxyoctyl)penicillanic acid and 6beta-(1R-hydroxyoctyl)penicillanic acid as mechanistic probes of class D beta-lactamases.

S. Mobashery, Mijoon Lee, D. Hesek, 2009, Organic letters.

Synthesis and NMR characterization of (Z,Z,Z,Z,E,E,ω)-heptaprenol.

J. Zajicek, S. Mobashery, J. Fisher, 2012, Journal of the American Chemical Society.

β-Lactam Resistance Mechanisms: Gram-Positive Bacteria and Mycobacterium tuberculosis.

S. Mobashery, J. Fisher, 2016, Cold Spring Harbor perspectives in medicine.

The use of triphosgene in preparation of N-carboxy .alpha.-amino acid anhydrides

S. Mobashery, R. Wilder, 1992 .

Evaluation of inhibition of the carbenicillin‐hydrolyzing β‐lactamase PSE‐4 by the clinically used mechanism‐based inhibitors

L. Kotra, F. Sanschagrin, S. Mobashery, 2000, FEBS letters.

The use of neamine as a molecular template: inactivation of bacterial antibiotic resistance enzyme aminoglycoside 3'-phosphotransferase type IIa.

S. Mobashery, J. Roestamadji, 1998, Bioorganic & medicinal chemistry letters.

Quantification of the extent of attenuation of the rate of turnover chemistry of the TEM-1 β-lactamase by the α-1R-hydroxyethyl group in substrates

I. Massova, S. Mobashery, K. Miyashita, 1996 .

Mechanistic support for the stepwise process for inactivation of class A β-lactamases by clavulanate

S. Mobashery, K. Miyashita, 1995 .

b -Lactam Resistance Mechanisms: Gram-Positive Bacteria and Mycobacterium tuberculosis

S. Mobashery, J. Fisher, 2016 .

MMP-1 and ADAM10 as Targets for Therapeutic Intervention in Idiopathic Pulmonary Fibrosis.

S. Mobashery, Mayland Chang, Man Wang, 2022, ACS pharmacology & translational science.

Selective MMP-9 Inhibitor (R)-ND-336 Alone or in Combination with Linezolid Accelerates Wound Healing in Infected Diabetic Mice.

S. Mobashery, Mijoon Lee, D. Hesek, 2020, ACS pharmacology & translational science.

Endogenous matrix metalloproteinases 2 and 9 regulate activation of CD4+ and CD8+ T cells.

Gerald N. Smith, S. Mobashery, F. Kheradmand, 2011, American journal of respiratory cell and molecular biology.

The complex of a designer antibiotic with a model aminoacyl site of the 30S ribosomal subunit revealed by X-ray crystallography.

J. Murray, R. Russell, S. Mobashery, 2003, Journal of the American Chemical Society.

Targeting extracellular matrix remodeling sensitizes glioblastoma to ionizing radiation

S. Welford, B. Bedogni, V. Thakur, 2022, Neuro-oncology advances.

Exploration of the structure-activity relationship of 1,2,4-oxadiazole antibiotics.

S. Mobashery, E. Lastochkin, Peter I. O’Daniel, 2015, Bioorganic & medicinal chemistry letters.

Synthesis of an inhibitor-tethered resin for detection of active matrix metalloproteinases involved in disease.

R. Fridman, S. Mobashery, M. Tóth, 2006, The Journal of organic chemistry.

Glyoxylyl Chloride p‐Toluenesulfonylhydrazone

J. Wang, S. Mobashery, Mingyi Liao, 2009 .

Investigation of signal transduction routes within the sensor/transducer protein BlaR1 of Staphylococcus aureus.

Jeffrey W. Peng, Thomas E Frederick, S. Mobashery, 2015, Biochemistry.

From Genome to Proteome to Elucidation of Reactions for All Eleven Known Lytic Transglycosylases from Pseudomonas aeruginosa.

David A. Dik, S. Mobashery, J. Fisher, 2017, Angewandte Chemie.

Catalytic Spectrum of the Penicillin-Binding Protein 4 of Pseudomonas aeruginosa, a Nexus for the Induction of β-Lactam Antibiotic Resistance

S. Mobashery, J. Fisher, Mijoon Lee, 2014, Journal of the American Chemical Society.

A chemical biological strategy to facilitate diabetic wound healing.

M. Suckow, Hualiang Pi, S. Mobashery, 2014, ACS chemical biology.

Fluorescence Assessment of the AmpR-Signaling Network of Pseudomonas aeruginosa to Exposure to β-Lactam Antibiotics.

David A. Dik, S. Mobashery, Choonkeun Kim, 2020, ACS chemical biology.

Structural and Functional Insights into Peptidoglycan Access for the Lytic Amidase LytA of Streptococcus pneumoniae

D. Svergun, S. Normark, A. Kikhney, 2014, mBio.

Crystal structure of CbpF, a bifunctional choline‐binding protein and autolysis regulator from Streptococcus pneumoniae

N. Campillo, R. Molina, J. Hermoso, 2009, EMBO reports.

Effect of synthetic matrix metalloproteinase inhibitors on lipopolysaccharide-induced blood–brain barrier opening in rodents: Differences in response based on strains and solvents

S. Mobashery, G. Rosenberg, Eduardo Y. Estrada, 2007, Brain Research.

Bis(trichloromethyl) Carbonate

Abhisek Banerjee, S. Mobashery, J. Roestamadji, 2006 .

The Use of Triphosgene in Preparation of N-Carboxy-α-amino Acid Anhydrides.

S. Mobashery, R. Wilder, 1992 .

Proteomics Identification of Targets for Intervention in Pressure Ulcers.

S. Mobashery, Valerie A. Schroeder, W. Wolter, 2022, ACS chemical biology.

The use of neamine as a molecular template: identification of active site residues in the bacterial antibiotic resistance enzyme aminoglycoside 3'-phosphotransferase type IIa by mass spectroscopy.

S. Mobashery, R. Orlando, Y. Yang, 1998, Bioorganic & medicinal chemistry letters.

MOLECULAR BASES FOR INTERACTIONS BETWEEN BETA -LACTAM ANTIBIOTICS AND BETA-LACTAMASES

I. Massova, S. Mobashery, 1997 .

Dissection of events in the resistance to β-lactam antibiotics mediated by the protein BlaR1 from Staphylococcus aureus.

S. Mobashery, Leticia I. Llarrull, 2012, Biochemistry.

Binding of the gene repressor BlaI to the bla operon in methicillin-resistant Staphylococcus aureus.

S. Mobashery, Leticia I. Llarrull, M. Prorok, 2010, Biochemistry.

Crystallization and preliminary X-ray diffraction analysis of the lytic transglycosylase MltE from Escherichia coli.

J. Hermoso, S. Mobashery, E. Lastochkin, 2011, Acta crystallographica. Section F, Structural biology and crystallization communications.

Potent and Selective Mechanism-Based Inhibition of Gelatinases

L. Kotra, M. Bernardo, R. Fridman, 2000 .

Active Site Ring‐Opening of a Thiirane Moiety and Picomolar Inhibition of Gelatinases

R. Fridman, S. Mobashery, Michael Gossing, 2009, Chemical biology & drug design.

Exploration of mild copper-mediated coupling of organotrifluoroborates in the synthesis of thiirane-based inhibitors of matrix metalloproteinases.

S. Mobashery, J. Fisher, R. Bouley, 2011, Bioorganic & medicinal chemistry letters.

Amidase Activity of AmiC Controls Cell Separation and Stem Peptide Release and Is Enhanced by NlpD in Neisseria gonorrhoeae*

K. Fisher, S. Mobashery, H. Seifert, 2016, The Journal of Biological Chemistry.

Bacterial Resistance to β‐Lactam Antibiotics: Compelling Opportunism, Compelling Opportunity

S. Meroueh, S. Mobashery, J. Fisher, 2005 .

Structure-activity relationship of the cinnamamide family of antibiotic potentiators for methicillin-resistant Staphylococcus aureus (MRSA).

S. Mobashery, Jennifer Fishovitz, Enrico Speri, 2018, MedChemComm.

Phosphorylation of BlaR1 in Manifestation of Antibiotic Resistance in Methicillin-Resistant Staphylococcus aureus and Its Abrogation by Small Molecules.

S. Mobashery, M. Boudreau, Leticia I. Llarrull, 2015, ACS infectious diseases.

Selective Inhibition of MMP-2 Does Not Alter Neurological Recovery after Spinal Cord Injury.

M. Suckow, Kiran V. Mahasenan, S. Mobashery, 2016, ACS chemical neuroscience.

X-ray Absorption Studies of Human Matrix Metalloproteinase-2 (MMP-2) Bound to a Highly Selective Mechanism-based Inhibitor COMPARISON WITH THE LATENT AND ACTIVE FORMS OF THE ENZYME*

L. Kotra, M. Bernardo, R. Fridman, 2001 .

AD Award Number : DAMD 1797-1-7174 TITLE : Novel and Selective Inactivators for Matrix . Metalloproteases Involved in Breast Cancer Metastasis

S. Mobashery, Jun, 2022 .

Lytic transglycosylases LtgA and LtgD perform distinct roles in remodeling, recycling and releasing peptidoglycan in Neisseria gonorrhoeae

S. Mobashery, Mijoon Lee, D. Hesek, 2016, Molecular microbiology.

Conformational analyses of thiirane-based gelatinase inhibitors.

S. Mobashery, J. Fisher, Mijoon Lee, 2008, Bioorganic & medicinal chemistry letters.

Muropeptides in Pseudomonas aeruginosa and their Role as Elicitors of β-Lactam-Antibiotic Resistance.

K. Mathee, S. Mobashery, Mijoon Lee, 2016, Angewandte Chemie.

Monitoring 1-Lactamase Activity In Vivo by 13C Nuclear Magnetic Resonance Spectroscopy

S. Mobashery, S. Lerner, 2022 .

The future of the β-lactams.

S. Mobashery, J. Fisher, S. Testero, 2010, Current opinion in microbiology.

The future of the b-lactams

S. Mobashery, J. Fisher, S. Testero, 2010 .

An Atypical ABC Transporter Is Involved in Antifungal Resistance and Host Interactions in the Pathogenic Fungus Cryptococcus neoformans

S. Mobashery, Yuanyuan Qian, F. Santiago-Tirado, 2022, bioRxiv.

Phosphoryl transfer by aminoglycoside 3'-phosphotransferases and manifestation of antibiotic resistance.

S. Mobashery, Choonkeun Kim, 2005, Bioorganic chemistry.

Source of Phosphate in the Enzymic Reaction as a Point of Distinction among Aminoglycoside 2″-Phosphotransferases*

S. Mobashery, M. Tóth, J. Chow, 2009, Journal of Biological Chemistry.

Activation by Allostery in Cell-Wall Remodeling by a Modular Membrane-Bound Lytic Transglycosylase from Pseudomonas aeruginosa.

David A. Dik, J. Hermoso, Kiran V. Mahasenan, 2016, Structure.

Unconventional Antibacterials and Adjuvants.

J. Hermoso, Kiran V. Mahasenan, S. Mobashery, 2021, Accounts of chemical research.

Total Syntheses of Bulgecins A, B, and C and Their Bactericidal Potentiation of the β-Lactam Antibiotics

David A. Dik, S. Mobashery, J. Fisher, 2018, ACS infectious diseases.

Bacterial AmpD at the crossroads of peptidoglycan recycling and manifestation of antibiotic resistance.

S. Mobashery, Mijoon Lee, D. Hesek, 2009, Journal of the American Chemical Society.

Potentiation of the activity of β-lactam antibiotics by farnesol and its derivatives.

S. Mobashery, Choonkeun Kim, Mijoon Lee, 2018, Bioorganic & medicinal chemistry letters.

In vitro studies of the protein-interaction network of cell-wall lytic transglycosylase RlpA of Pseudomonas aeruginosa

S. Mobashery, Choonkeun Kim, J. Fisher, 2022, Communications Biology.

Structure-activity relationship for the oxadiazole class of antibiotics.

M. Suckow, Hualiang Pi, S. Mobashery, 2015, Journal of medicinal chemistry.

Inactivation of the catalytic subunit of bovine cAMP‐dependent protein kinase by a peptide‐based affinity inactivator

E. Kaiser, S. Mobashery, M. Doughty, 1990, Biopolymers.

Aminoglycoside-modifying enzymes: mechanisms of catalytic processes and inhibition.

S. Mobashery, E. Azucena, 2001, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.

Versatility of Aminoglycosides and Prospects for Their Future

S. Mobashery, S. Vakulenko, Shahriar Mobashery, 2003, Clinical Microbiology Reviews.

Structure–Activity Relationship for the 4(3H)-Quinazolinone Antibacterials

Wei Song, Mark A. Suckow, M. Suckow, 2016, Journal of medicinal chemistry.

Synthesis of chiral 2-(4-phenoxyphenylsulfonylmethyl)thiiranes as selective gelatinase inhibitors.

S. Meroueh, M. Bernardo, R. Fridman, 2005, Organic letters.

Preparation of ceph-3-em esters unaccompanied by .DELTA.3 .fwdarw. .DELTA.2 isomerization of the cephalosporin

S. Mobashery, M. Johnston, 1986 .

Use of silver carbonate in the Wittig reaction.

S. Mobashery, J. Fisher, Mijoon Lee, 2013, The Journal of organic chemistry.

Methoxycarbonylsulfamoyl)triethylammonium Hydroxide

S. Mobashery, A. C. Hart, P. Taibi, 2008 .

The Natural Product Essramycin and Three of Its Isomers Are Devoid of Antibacterial Activity.

A. Oliver, S. Mobashery, Mijoon Lee, 2016, Journal of natural products.

Medicinal Chemistry of β‐Lactam Antibiotics

S. Mobashery, J. Fisher, S. Testero, 2021 .

Bacterial resistance to beta-lactam antibiotics: compelling opportunism, compelling opportunity.

Samy O Meroueh, S. Meroueh, S. Mobashery, 2005, Chemical reviews.

Synthesis and evaluation of 1,2,4-triazolo[1,5-a]pyrimidines as antibacterial agents against Enterococcus faecium.

Malika Kumarasiri, S. Mobashery, Mijoon Lee, 2015, Journal of medicinal chemistry.

Discovery of antibiotic (E)-3-(3-carboxyphenyl)-2-(4-cyanostyryl)quinazolin-4(3H)-one.

M. Suckow, J. Hermoso, Malika Kumarasiri, 2015, Journal of the American Chemical Society.

Aminoglycoside Antibiotics: Structures and Mechanisms of Action

L. Kotra, S. Mobashery, J. Haddad, 2001 .

Resolving the antibiotic paradox: progress in understanding drug resistance and development of new antibiotics.

S. Mobashery, B. Rosen, 1998 .

How β-Lactamases Have Driven Pharmaceutical Drug Discovery

K. Bush, S. Mobashery, 1998 .

Inhibition of the NMC-A β-Lactamase by a Penicillanic Acid Derivative and the Structural Bases for the Increase in Substrate Profile of This Antibiotic Resistance Enzyme

L. Mourey, J. Samama, S. Mobashery, 1998 .

Crystal Structure of 6Alpha-Hydroxymethylpenicillanate Complexed to the Tem-1 Beta-Lactamase from Escherichia Coli: Evidence on the Mechanism of Action of a Novel Inhibitor Designed by a Computer-Aided Process

Laurent Maveyraud, Irina Massova, I. Massova, 1996 .

Design, Synthesis, and Evaluation of a Potent Mechanism-Based Inhibitor for the TEM .beta.-Lactamase with Implications for the Enzyme Mechanism

I. Massova, S. Mobashery, K. Miyashita, 1995 .

β-Lactams against the Fortress of the Gram-Positive Staphylococcus aureus Bacterium.

S. Mobashery, J. Fisher, 2020, Chemical reviews.

N-Sulfonyloxy-β-lactam Inhibitors for β-Lactamases

J. Samama, M. O’Brien, S. Mobashery, 2000 .

Co-opting the cell wall in fighting methicillin-resistant Staphylococcus aureus: potent inhibition of PBP 2a by two anti-MRSA beta-lactam antibiotics.

S. Mobashery, S. Vakulenko, Mijoon Lee, 2008, Journal of the American Chemical Society.

Structural Basis for Clinical Longevity of Carbapenem Antibiotics in the Face of Challenge by the Common Class A Beta-Lactamases from Antibiotic-Resistant Bacteria

Laurent Maveyraud, Lakshmi P. Kotra, L. Kotra, 1998 .

Resolving the Antibiotic Paradox

S. Mobashery, B. Rosen, 1998, Advances in Experimental Medicine and Biology.

Insertion of Epicatechin Gallate into the Cytoplasmic Membrane of Methicillin-resistant Staphylococcus aureus Disrupts Penicillin-binding Protein (PBP) 2a-mediated β-Lactam Resistance by Delocalizing PBP2

J. Hinds, M. G. Pinho, S. Mobashery, 2010, The Journal of Biological Chemistry.

Messenger functions of the bacterial cell wall-derived muropeptides.

S. Mobashery, J. Fisher, M. Boudreau, 2012, Biochemistry.

Effects on Substrate Profile by Mutational Substitutions at Positions 164 and 179 of the Class A TEMpUC19 β-Lactamase from Escherichia coli*

I. Massova, S. Mobashery, M. Tóth, 1999, The Journal of Biological Chemistry.

Inhibitors for Bacterial Cell-Wall Recycling.

A. Oliver, S. Mobashery, J. Fisher, 2012, ACS medicinal chemistry letters.

Total synthesis of N-acetylglucosamine-1,6-anhydro-N-acetylmuramylpentapeptide and evaluation of its turnover by AmpD from Escherichia coli.

S. Mobashery, Mijoon Lee, D. Hesek, 2009, Journal of the American Chemical Society.

Stereoselective reduction of alpha-bromopenicillanates by tributylphosphine.

L. Kotra, S. Mobashery, K. Miyashita, 2000, Organic letters.

O-phenyl carbamate and phenyl urea thiiranes as selective matrix metalloproteinase-2 inhibitors that cross the blood-brain barrier.

M. Suckow, Kiran V. Mahasenan, S. Mobashery, 2013, Journal of medicinal chemistry.

Thermodynamics of interactions of vancomycin and synthetic surrogates of bacterial cell wall.

S. Meroueh, S. Mobashery, Y. Inoue, 2006, Journal of the American Chemical Society.

A Convenient Triphosgene-Mediated Synthesis of Symmetric Carboxylic Acid Anhydrides

S. Mobashery, J. Roestamadji, R. Kocz, 1994 .

Design, synthesis, and evaluation of a mechanism-based inhibitor for gelatinase A.

S. Meroueh, M. Bernardo, R. Fridman, 2005, The Journal of organic chemistry.

Preparation of Ceph-3-em Esters Unaccompanied by δ3 → δ2 Isomerization of the Cephalosporin.

S. Mobashery, M. Johnston, 1987 .

1H-NMR analysis of copper-aminoglycoside complexes in solution and its implication for regioselective modification of multifunctional aminoglycoside antibiotics

I. Massova, S. Mobashery, I. Grapsas, 1998 .

Short Alkylated Peptoid Mimics of Antimicrobial Lipopeptides

Amy J. Karlsson, A. Barron, S. Palecek, 2010, Antimicrobial Agents and Chemotherapy.

Synthesis and shift-reagent-assisted full NMR assignment of bacterial (Z8,E2,ω)-undecaprenol.

J. Zajicek, S. Mobashery, J. Fisher, 2017, Chemical communications.

A Potent Gelatinase Inhibitor with Anti‐Tumor‐Invasive Activity and its Metabolic Disposition

M. Suckow, M. Bernardo, R. Fridman, 2009, Chemical biology & drug design.

Discrete steps in sensing of beta-lactam antibiotics by the BlaR1 protein of the methicillin-resistant Staphylococcus aureus bacterium.

C. Wharton, S. Mobashery, J. Fisher, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Dynamics of the Lipopolysaccharide Assembly on the Surface of Escherichia coli

L. Kotra, Gang-yu Liu, S. Mobashery, 1999 .

Selection and Characterization of β-Lactam–β-Lactamase Inactivator-Resistant Mutants following PCR Mutagenesis of the TEM-1 β-Lactamase Gene

Lakshmi P. Kotra, L. Kotra, S. Mobashery, 1998, Antimicrobial Agents and Chemotherapy.

Selection and characterization of beta-lactam-beta-lactamase inactivator-resistant mutants following PCR mutagenesis of the TEM-1 beta-lactamase gene.

L. Kotra, S. Mobashery, S. Vakulenko, 1998, Antimicrobial agents and chemotherapy.

Cell-Wall Recycling of the Gram-Negative Bacteria and the Nexus to Antibiotic Resistance.

David A. Dik, S. Mobashery, J. Fisher, 2018, Chemical reviews.

Roles of Matrix Metalloproteinases in Cutaneous Wound Healing

S. Mobashery, Mayland Chang, Trung T. Nguyen, 2016 .

Reversal of clavulanate resistance conferred by a Ser-244 mutant of TEM-1 beta-lactamase as a result of a second mutation (Arg to Ser at position 164) that enhances activity against ceftazidime

S. Mobashery, S. Lerner, E. Manavathu, 1994, Antimicrobial Agents and Chemotherapy.

Resistance -Lactam β Penicillin-Binding Protein 5 in Pseudomonas aeruginosa Structural Analysis of the Role of

Malika Kumarasiri, S. Mobashery, M. Tóth, 2014 .

Mutational Replacement of Leu-293 in the Class C Enterobacter cloacae P99 β-Lactamase Confers Increased MIC of Cefepime

S. Mobashery, S. Vakulenko, S. Lerner, 2002, Antimicrobial Agents and Chemotherapy.

Class C β-Lactamases Operate at the Diffusion Limit for Turnover of Their Preferred Cephalosporin Substrates

S. Mobashery, A. Bulychev, 1999, Antimicrobial Agents and Chemotherapy.

Antibacterials: Volume II

S. Mobashery, J. Fisher, Marvin J. Miller, 2018 .

Bacterial cell‐wall recycling

S. Mobashery, J. Fisher, Jed F Fisher, 2013, Annals of the New York Academy of Sciences.

Three-dimensional structure of the bacterial cell wall peptidoglycan.

S. Meroueh, T. Stemmler, S. Mobashery, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Integrative structural biology of the penicillin-binding protein-1 from Staphylococcus aureus, an essential component of the divisome machinery

I. Muñoz, R. Molina, J. Hermoso, 2021, Computational and structural biotechnology journal.

Exploration of the Structural Space in 4(3H)-Quinazolinone Antibacterials.

Kiran V. Mahasenan, S. Mobashery, E. Lastochkin, 2020, Journal of medicinal chemistry.

Mechanistic Basis for the Emergence of Catalytic Competence against Carbapenem Antibiotics by the GES Family of β-Lactamases

S. Mobashery, S. Vakulenko, Hilary Frase, 2009, The Journal of Biological Chemistry.

β-Lactam resistance in Staphylococcus aureus: the adaptive resistance of a plastic genome

S. Mobashery, J. Fisher, C. Fuda, 2005, Cellular and Molecular Life Sciences.

The sentinel role of peptidoglycan recycling in the β-lactam resistance of the Gram-negative Enterobacteriaceae and Pseudomonas aeruginosa.

S. Mobashery, J. Fisher, 2014, Bioorganic chemistry.

Molecular dynamics at the root of expansion of function in the M69L inhibitor-resistant TEM beta-lactamase from Escherichia coli.

Yun Zhang, Laurent Maveyraud, Samy O Meroueh, 2002, Journal of the American Chemical Society.

Strategies for Circumventing Bacterial Resistance Mechanisms

S. Mobashery, J. Fisher, J. Johnson, 2014 .

Strategies to Counter Resistance Mechanisms of Action and Resistance and Aminoglycosides : Perspectives on

L. Kotra, S. Mobashery, J. Haddad, 2000 .

Aminoglycoside antibiotics. Structures, functions, and resistance.

G. Wright, A. Berghuis, S. Mobashery, 1998, Advances in experimental medicine and biology.

Structural basis for carbapenemase activity of the OXA-23 β-lactamase from Acinetobacter baumannii.

Malika Kumarasiri, S. Mobashery, M. Tóth, 2013, Chemistry and Biology.

Critical involvement of a carbamylated lysine in catalytic function of class D β-lactamases

J. Samama, S. Mobashery, L. Maveyraud, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Mechanism of anchoring of OmpA protein to the cell wall peptidoglycan of the gram‐negative bacterial outer membrane

Jung Hyun Song, Malika Kumarasiri, S. Mobashery, 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

The external PASTA domain of the essential serine/threonine protein kinase PknB regulates mycobacterial growth

P. Barthe, W. Vollmer, A. Bottrill, 2015, Open Biology.

Recognition of peptidoglycan and β‐lactam antibiotics by the extracellular domain of the Ser/Thr protein kinase StkP from Streptococcus pneumoniae

L. Nováková, P. Branny, S. Mobashery, 2011, FEBS letters.

Key side products due to reactivity of dimethylmaleoyl moiety as amine protective group

S. Mobashery, Mijoon Lee, D. Hesek, 2009, Chemicke zvesti.

Design of novel antibiotics that bind to the ribosomal acyltransfer site.

Lakshmi P Kotra, L. Kotra, S. Mobashery, 2002, Journal of the American Chemical Society.

An Antibiotic Cloaked by Its Own Resistance Enzyme

S. Mobashery, J. Haddad, and Sergei Vakulenko, 1999 .

Aminoglycosides: Perspectives on Mechanisms of Action and Resistance and Strategies to Counter Resistance

L. Kotra, S. Mobashery, J. Haddad, 2000, Antimicrobial Agents and Chemotherapy.

The bifunctional enzymes of antibiotic resistance.

S. Mobashery, J. Fisher, Weilie Zhang, 2009, Current opinion in microbiology.

LOSS OF INDIVIDUAL ELECTROSTATIC INTERACTIONS BETWEEN AMINOGLYCOSIDE ANTIBIOTICS AND RESISTANCE ENZYMES AS AN EFFECTIVE MEANS TO OVERCOMING BACTERIAL DRUG RESISTANCE

S. Mobashery, J. Roestamadji, I. Grapsas, 1995 .

Interactions of designer antibiotics and the bacterial ribosomal aminoacyl-tRNA site.

Samy O Meroueh, J. Murray, S. Meroueh, 2006, Chemistry & biology.

Conformational Transition in the Aminoacyl t‐RNA Site of the Bacterial Ribosome both in the Presence and Absence of an Aminoglycoside Antibiotic

S. Meroueh, S. Mobashery, 2007, Chemical biology & drug design.

Recognition of aminoglycoside antibiotics by enterococcal-staphylococcal aminoglycoside 3'-phosphotransferase type IIIa: role of substrate amino groups

G. Wright, S. Mobashery, G. McKay, 1996, Antimicrobial agents and chemotherapy.

HYDROLYSIS OF ATP BY AMINOGLYCOSIDE 3’- PHOSPHOTRANSFERASES: AN UNEXPECTED COST TO BACTERIA FOR HARBORING AN ANTIBIOTIC RESISTANCE ENZYME

Honggao Yan, S. Mobashery, Choonkeun Kim, 2005 .

Purification, characterization, and investigation of the mechanism of aminoglycoside 3'-phosphotransferase type Ia.

S. Mobashery, K. Miroshnikov, J. Siregar, 1995, Biochemistry.

Purification and characterization of aminoglycoside 3'-phosphotransferase type IIa and kinetic comparison with a new mutant enzyme

S. Mobashery, S. Lerner, J. Siregar, 1994, Antimicrobial Agents and Chemotherapy.

The Cell Shape-determining Csd6 Protein from Helicobacter pylori Constitutes a New Family of l,d-Carboxypeptidase

Nam Ki Lee, M. Cui, Sun Choi, 2015, The Journal of Biological Chemistry.

In Search of Selectivity in Inhibition of ADAM10.

M. Suckow, Kiran V. Mahasenan, S. Mobashery, 2018, ACS medicinal chemistry letters.

Collagen-mediated Signaling Receptor Tyrosine Kinases in Discoidin Domain Receptors : Unique Minireviews :

Paul H. Huang, R. Fridman, Malika Kumarasiri, 2013 .

Structural basis for the recognition of muramyltripeptide by Helicobacter pylori Csd4, a d,l-carboxypeptidase controlling the helical cell shape

S. Suh, S. Mobashery, B. Han, 2014, Acta crystallographica. Section D, Biological crystallography.

Lytic transglycosylases: concinnity in concision of the bacterial cell wall

David A. Dik, S. Mobashery, J. Fisher, 2017, Critical reviews in biochemistry and molecular biology.

Shedding of Discoidin Domain Receptor 1 by Membrane-type Matrix Metalloproteinases*

M. Bernardo, R. Fridman, Malika Kumarasiri, 2013, The Journal of Biological Chemistry.

Cell surface association of matrix metalloproteinase-9 (gelatinase B)

S. Meroueh, R. Fridman, S. Mobashery, 2003, Cancer and Metastasis Reviews.

Matrix metalloproteinases: structures, evolution, and diversification

L. Kotra, I. Massova, R. Fridman, 1998, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Protonation states of active‐site lysines of penicillin‐binding protein 6 from Escherichia coli and the mechanistic implications

Malika Kumarasiri, S. Mobashery, J. Fisher, 2014, Proteins.

Testosterone-Induced Matrix Metalloproteinase Activation Is a Checkpoint for Neuronal Addition to the Adult Songbird Brain

S. Goldman, Zhuoxun Chen, S. Mobashery, 2008, The Journal of Neuroscience.

How allosteric control of Staphylococcus aureus penicillin binding protein 2a enables methicillin resistance and physiological function

J. Hermoso, Malika Kumarasiri, C. Carrasco-López, 2013, Proceedings of the National Academy of Sciences.

Validation of Matrix Metalloproteinase-9 (MMP-9) as a Novel Target for Treatment of Diabetic Foot Ulcers in Humans and Discovery of a Potent and Selective Small-Molecule MMP-9 Inhibitor That Accelerates Healing.

M. Suckow, Kiran V. Mahasenan, S. Mobashery, 2018, Journal of medicinal chemistry.

Structure-Activity Relationship for the Picolinamide Antibacterials that Selectively Target Clostridioides difficile.

A. Oliver, S. Mobashery, J. Fisher, 2021, ACS medicinal chemistry letters.

Insights into the three-dimensional structure of crotalase: Implications for biological activity and substrate specificity

I. Massova, B. Edwards, S. Mobashery, 1997 .

Mechanism-based profiling of MMPs.

S. Mobashery, J. Fisher, 2010, Methods in molecular biology.

In Vitro and In Vivo Synergy of the Oxadiazole Class of Antibacterials with β-Lactams

S. Mobashery, Jeshina Janardhanan, Derong Ding, 2016, Antimicrobial Agents and Chemotherapy.

Exploitation of Conformational Dynamics in Imparting Selective Inhibition for Related Matrix Metalloproteinases.

M. Suckow, Kiran V. Mahasenan, S. Mobashery, 2017, ACS medicinal chemistry letters.

β-Lactams from the Ocean

S. Mobashery, J. Fisher, 2023, Marine drugs.

From genes to sequences to antibiotics: prospects for future developments from microbial genomics.

L. Kotra, S. Vakulenko, S. Mobashery, 2000, Microbes and infection.

Identification and Role of the Homodimerization Interface of the Glycosylphosphatidylinositol-anchored Membrane Type 6 Matrix Metalloproteinase (MMP25)*

R. Fridman, A. Sohail, S. Mobashery, 2008, Journal of Biological Chemistry.

UPDATES AND DEVELOPMENTS IN ONCOLOGY

R. Fridman, S. Mobashery, M. Cher, 2006 .

Antimetastatic activity of a novel mechanism-based gelatinase inhibitor.

A. Krüger, M. Bernardo, R. Fridman, 2005, Cancer research.

13 Bacterial Cell Wall Morphology and Biochemistry

S. Mobashery, J. Fisher, M. Suvorov, 2009 .

Bacterial Cell Wall

S. Mobashery, J. Fisher, 2015 .

Nanomolecular and Supramolecular Paths toward Peptidoglycan Structure

S. Meroueh, S. Mobashery, J. Fisher, 2006 .

Insights into pneumococcal fratricide from the crystal structures of the modular killing factor LytC

J. García, J. Hermoso, W. Vollmer, 2010, Nature Structural &Molecular Biology.

Crystal Structures of Bacterial

T. Krell, J. Hermoso, S. Mobashery, 2011 .

Reactions of all Escherichia coli lytic transglycosylases with bacterial cell wall.

Hualiang Pi, S. Mobashery, Mijoon Lee, 2013, Journal of the American Chemical Society.

Catalytic mechanism of penicillin-binding protein 5 of Escherichia coli.

S. Meroueh, S. Mobashery, S. Vakulenko, 2007, Biochemistry.

Slt, MltD, and MltG of Pseudomonas aeruginosa as Targets of Bulgecin A in Potentiation of β-Lactam Antibiotics.

David A. Dik, W. Boggess, S. Mobashery, 2019, ACS chemical biology.

Catalytic Cycle of the N-Acetylglucosaminidase NagZ from Pseudomonas aeruginosa.

J. Hermoso, Kiran V. Mahasenan, S. Mobashery, 2017, Journal of the American Chemical Society.

Corrigendum: Muropeptides in Pseudomonas aeruginosa and their Role as Elicitors of β-Lactam-Antibiotic Resistance.

K. Mathee, S. Mobashery, Mijoon Lee, 2016, Angewandte Chemie.

Orthologous and Paralogous AmpD Peptidoglycan Amidases from Gram-Negative Bacteria

R. Molina, J. Hermoso, S. Mobashery, 2016, Microbial drug resistance.

Turnover of Bacterial Cell Wall by SltB3, a Multidomain Lytic Transglycosylase of Pseudomonas aeruginosa.

J. Hermoso, Kiran V. Mahasenan, S. Mobashery, 2016, ACS chemical biology.

Cell-wall remodeling by the zinc-protease AmpDh3 from Pseudomonas aeruginosa.

L. Hellman, J. Hermoso, C. Carrasco-López, 2013, Journal of the American Chemical Society.

Reaction products and the X-ray structure of AmpDh2, a virulence determinant of Pseudomonas aeruginosa.

L. Hellman, J. Hermoso, C. Carrasco-López, 2013, Journal of the American Chemical Society.

Effect of ablation or inhibition of stromal matrix metalloproteinase-9 on lung metastasis in a breast cancer model is dependent on genetic background.

B. Fingleton, L. Matrisian, S. Mobashery, 2008, Cancer research.

Tissue Inhibitor of Metalloproteinase (TIMP)-2 Acts Synergistically with Synthetic Matrix Metalloproteinase (MMP) Inhibitors but Not with TIMP-4 to Enhance the (Membrane Type 1)-MMP-dependent Activation of Pro-MMP-2*

C. Overall, M. Bernardo, R. Fridman, 2000, The Journal of Biological Chemistry.

Crystal Structures of Bacterial Peptidoglycan Amidase AmpD and an Unprecedented Activation Mechanism*

I. André, J. Hermoso, C. Carrasco-López, 2011, The Journal of Biological Chemistry.

Identification of colchicine in placental blood from patients using herbal medicines.

H. Petty, S. Mobashery, M. Ksebati, 2001, Chemical research in toxicology.

Kinship and Diversification of Bacterial Penicillin-Binding Proteins and β-Lactamases

I. Massova, S. Mobashery, 1998, Antimicrobial Agents and Chemotherapy.

Inhibition of Class A β-Lactamases

S. Meroueh, S. Mobashery, J. Cha, 2007 .

Structure and Cell Wall Cleavage by Modular Lytic Transglycosylase MltC of Escherichia coli

J. Hermoso, Hualiang Pi, Kiran V. Mahasenan, 2014, ACS chemical biology.

Three Decades of the Class A β-Lactamase Acyl-Enzyme

S. Mobashery, J. Fisher, Shahriar Mobashery, 2009 .

Structural basis of denuded glycan recognition by SPOR domains in bacterial cell division

David A. Dik, J. Hermoso, Daniel López, 2019, Nature Communications.

Inhibition of human prostate cancer growth, osteolysis and angiogenesis in a bone metastasis model by a novel mechanism‐based selective gelatinase inhibitor

M. Bernardo, R. Fridman, S. Mobashery, 2006, International journal of cancer.

Turnover of Bacterial Cell Wall by SltB3, a Multidomain Lytic Transglycosylase of Pseudomonas aeruginosa.

J. Hermoso, Kiran V. Mahasenan, S. Mobashery, 2016, ACS chemical biology.

High-resolution crystal structure of MltE, an outer membrane-anchored endolytic peptidoglycan lytic transglycosylase from Escherichia coli.

J. Hermoso, Malika Kumarasiri, C. Carrasco-López, 2011, Biochemistry.

Purification of recombinant pp60v-src protein tyrosine kinase and phosphorylation of peptides with different secondary structure preference.

W. Miller, C. Radziejewski, E. Kaiser, 1989, Biochemistry.

Mutational and Structural Analyses of the Hinge Region of Membrane Type 1-Matrix Metalloproteinase and Enzyme Processing*

S. Meroueh, R. Fridman, S. Mobashery, 2005, Journal of Biological Chemistry.

Identification of amino acid residues involved in substrate recognition by the catalytic subunit of bovine cyclic AMP dependent protein kinase: peptide-based affinity labels.

E. Kaiser, S. Mobashery, 1988, Biochemistry.

Characterization of the Dimerization Interface of Membrane Type 4 (MT4)-Matrix Metalloproteinase*

R. Fridman, A. Sohail, S. Mobashery, 2011, The Journal of Biological Chemistry.

Synergistic, collaterally sensitive β-lactam combinations suppress resistance in MRSA

Brent A. Biddy, G. Dantas, M. Suckow, 2015, Nature chemical biology.

A Highly Specific Inhibitor of Matrix Metalloproteinase-9 Rescues Laminin from Proteolysis and Neurons from Apoptosis in Transient Focal Cerebral Ischemia

Jiankun Cui, A. Strongin, S. Lipton, 2005, The Journal of Neuroscience.

Lysine Nζ-Decarboxylation Switch and Activation of the β-Lactam Sensor Domain of BlaR1 Protein of Methicillin-resistant Staphylococcus aureus*

Jeffrey W. Peng, B. Baker, Malika Kumarasiri, 2011, The Journal of Biological Chemistry.

Regioselective Control of the SNAr Amination of 5-Substituted-2,4-Dichloropyrimidines Using Tertiary Amine Nucleophiles.

A. Oliver, S. Mobashery, J. Fisher, 2015, The Journal of organic chemistry.

Structural consequences of the inhibitor-resistant Ser130Gly substitution in TEM beta-lactamase.

Brian K Shoichet, B. Shoichet, D. Golemi-Kotra, 2005, Biochemistry.

A dynamic structure for the acyl-enzyme species of the antibiotic aztreonam with the Citrobacter freundii beta-lactamase revealed by infrared spectroscopy and molecular dynamics simulations.

M. Page, C. Wharton, P. K. Bryant, 2003, Biochemistry.

Bacterial Antibiotic Resistance

S. Mobashery, E. Azucena, 2003 .

Resistance to the third-generation cephalosporin ceftazidime by a deacylation-deficient mutant of the TEM β-lactamase by the uncommon covalent-trapping mechanism.

S. Mobashery, M. Tóth, S. Vakulenko, 2011, Biochemistry.

B -lactamases And Resistance To B-lactam Antibiotics

L. Kotra, J. Samama, S. Mobashery, 2001 .

An Amino Acid Position at Crossroads of Evolution of Protein Function

B. Baker, Malika Kumarasiri, S. Mobashery, 2012, The Journal of Biological Chemistry.

A structure-based analysis of the inhibition of class A beta-lactamases by sulbactam.

S. Mobashery, E. Billings, J. Knox, 1994, Biochemistry.

Selection and Characterization of b-Lactam – b-Lactamase Inactivator-Resistant Mutants following PCR Mutagenesis of the TEM-1 b-Lactamase Gene

L. Kotra, S. Mobashery, S. Vakulenko, 1998 .

Elucidation of the role of arginine-244 in the turnover processes of class A beta-lactamases.

S. Mobashery, S. Lerner, E. Manavathu, 1992, Biochemistry.

Regioselective Control of the SNAr Amination of 5‐Substituted‐2,4‐dichloropyrimidines Using Tertiary Amine Nucleophiles.

A. Oliver, S. Mobashery, J. Fisher, 2015 .

Selective water-soluble gelatinase inhibitor prodrugs.

M. Suckow, S. Mobashery, Mijoon Lee, 2011, Journal of medicinal chemistry.

Metabolism of (4‐Phenoxyphenylsulfonyl)methylthiirane, a Selective Gelatinase Inhibitor

M. Suckow, S. Mobashery, Mijoon Lee, 2008 .

Metabolism of a Highly Selective Gelatinase Inhibitor Generates Active Metabolite

R. Fridman, S. Mobashery, M. Tóth, 2007, Chemical biology & drug design.

The oxadiazole antibacterials.

S. Mobashery, Jeshina Janardhanan, Mayland Chang, 2016, Current opinion in microbiology.

Structure-Activity Relationship for the Oxadiazole Class of Antibacterials.

M. Suckow, S. Mobashery, E. Lastochkin, 2019, ACS medicinal chemistry letters.

Whole-Genome Shotgun Sequencing of Two β-Proteobacterial Species in Search of the Bulgecin Biosynthetic Cluster

Ryan A Oliver, C. Townsend, S. Emrich, 2017, ACS chemical biology.

Insights into class D beta-lactamases are revealed by the crystal structure of the OXA10 enzyme from Pseudomonas aeruginosa.

L. Kotra, J. Samama, S. Tranier, 2000, Structure.

Inhibition of MMP-9 by a selective gelatinase inhibitor protects neurovasculature from embolic focal cerebral ischemia

Jiankun Cui, Z. Gu, Fanjun Meng, 2012, Molecular Neurodegeneration.

Production of Proteins of the SARS-CoV-2 Proteome for Drug Discovery

A. Bhardwaj, O. Wiest, Kiran V. Mahasenan, 2021, ACS omega.

Characterization of the bifunctional aminoglycoside-modifying enzyme ANT(3'')-Ii/AAC(6')-IId from Serratia marcescens.

J. Zajicek, S. Mobashery, Choonkeun Kim, 2006, Biochemistry.

Aminoglycoside 2″-Phosphotransferase Type IIIa from Enterococcus*

J. Zajicek, S. Mobashery, J. Chow, 2008, Journal of Biological Chemistry.

Selective Inhibition of Matrix Metalloproteinase-9 Attenuates Secondary Damage Resulting from Severe Traumatic Brain Injury

B. N. Tomlinson, Jiankun Cui, Dmitriy Shin, 2013, PloS one.

Pronounced Diversity in Electronic and Chemical Properties between the Catalytic Zinc Sites of Tumor Necrosis Factor-α-converting Enzyme and Matrix Metalloproteinases despite Their High Structural Similarity*

M. Milla, S. Mobashery, A. Solomon, 2004, Journal of Biological Chemistry.

Antibacterials: Volume I

S. Mobashery, R. Melander, C. Melander, 2018 .

Mutations in mmpL and in the Cell Wall Stress Stimulon Contribute to Resistance to Oxadiazole Antibiotics in Methicillin-Resistant Staphylococcus aureus

S. Mobashery, S. Vakulenko, Mayland Chang, 2014, Antimicrobial Agents and Chemotherapy.

aureusstant Staphylococcus to Oxadiazole Antibiotics in Stress Stimulon Contribute to Resistance and in the Cell Wall mmpL Mutations in

S. Mobashery, S. Vakulenko, Mayland Chang, 2014 .

Inactivation of alanine racemase by beta-chloro-L-alanine released enzymatically from amino acid and peptide C10-esters of deacetylcephalothin.

S. Mobashery, M. Johnston, 1987, Biochemistry.

Monitoring beta-lactamase activity in vivo by 13C nuclear magnetic resonance spectroscopy

S. Mobashery, S. Lerner, M. Johnston, 1988, Antimicrobial Agents and Chemotherapy.

Conscripting β-Lactamase for Use in Drug Delivery. Synthesis and Biological Activity of a Cephalosporin C10-Ester of an Antibiotic Dipeptide.

S. Mobashery, S. Lerner, M. Johnston, 1986 .

Substrate recognition and catalysis by LytB, a pneumococcal peptidoglycan hydrolase involved in virulence

M. Menéndez, W. Vollmer, S. Mobashery, 2015, Scientific Reports.

Structural Basis for Potent Slow Binding Inhibition of Human Matrix Metalloproteinase-2 (MMP-2)*

S. Meroueh, R. Fridman, S. Mobashery, 2003, Journal of Biological Chemistry.

Quest for selectivity in inhibition of matrix metalloproteinases.

S. Meroueh, R. Fridman, S. Mobashery, 2004, Current topics in medicinal chemistry.

Complex Pattern of Membrane Type 1 Matrix Metalloproteinase Shedding

L. Kotra, Y. Shimura, M. Bernardo, 2002, The Journal of Biological Chemistry.

The Allosteric Site for the Nascent Cell Wall in Penicillin-Binding Protein 2a: An Achilles' Heel of Methicillin-Resistant Staphylococcus aureus.

J. Hermoso, S. Mobashery, Mayland Chang, 2015, Current medicinal chemistry.

Restoration of Susceptibility of Methicillin-resistant Staphylococcus aureus to β-Lactam Antibiotics by Acidic pH

S. Mobashery, P. Tulkens, F. Van Bambeke, 2008, Journal of Biological Chemistry.

Penicillin‐binding protein 2a of methicillin‐resistant Staphylococcus aureus

J. Hermoso, S. Mobashery, Mayland Chang, 2014, IUBMB life.

The Tipper-Strominger Hypothesis and Triggering of Allostery in Penicillin-Binding Protein 2a of Methicillin-Resistant Staphylococcus aureus (MRSA).

S. Mobashery, J. Fisher, Mayland Chang, 2015, Journal of the American Chemical Society.

Shared functional attributes between the mecA gene product of Staphylococcus sciuri and penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus.

S. Mobashery, Mijoon Lee, D. Hesek, 2007, Biochemistry.

Lysine carboxylation in proteins: OXA‐10 β‐lactamase

H. Schlegel, T. Vreven, S. Meroueh, 2005 .

The First Structural and Mechanistic Insights for Class D beta-Lactamases: Evidence for a Novel Catalytic Process for Turnover of beta-Lactam Antibiotics

L. Kotra, J. Samama, S. Tranier, 2000 .

Templates for design of inhibitors for serine proteases: application of the program DOCK to the discovery of novel inhibitors for thrombin.

I. Massova, B. Edwards, S. Mobashery, 1998, Bioorganic & medicinal chemistry letters.

Early Abrogation of Gelatinase Activity Extends the Time Window for tPA Thrombolysis after Embolic Focal Cerebral Ischemia in Mice

Jiankun Cui, Hailong Song, Z. Gu, 2018, eNeuro.

AAC(3)-XI, a New Aminoglycoside 3-N-Acetyltransferase from Corynebacterium striatum

V. Barbe, J. Zajicek, S. Mobashery, 2015, Antimicrobial Agents and Chemotherapy.

A computational evaluation of the mechanism of penicillin-binding protein-catalyzed cross-linking of the bacterial cell wall.

S. Meroueh, S. Mobashery, J. Fisher, 2011, Journal of the American Chemical Society.

Discovery of a potent picolinamide antibacterial active against Clostridioides difficile.

S. Mobashery, J. Fisher, E. Lastochkin, 2020, ACS infectious diseases.

Cinnamonitrile Adjuvants Restore Susceptibility to β-Lactams against Methicillin-Resistant Staphylococcus aureus.

S. Mobashery, Choonkeun Kim, J. Fisher, 2019, ACS medicinal chemistry letters.

Crystal structures of penicillin-binding protein 6 from Escherichia coli.

B. Shoichet, S. Mobashery, Yu Chen, 2009, Journal of the American Chemical Society.

Sulfonate-containing thiiranes as selective gelatinase inhibitors.

S. Mobashery, M. Tóth, Mijoon Lee, 2011, ACS medicinal chemistry letters.

Potent mechanism-based inhibition of the TEM-1 .beta.-lactamase by novel N-sulfonyloxy .beta.-lactams

I. Massova, M. O’Brien, S. Mobashery, 1995 .

Selective gelatinase inhibitor neuroprotective agents cross the blood-brain barrier.

M. Suckow, S. Mobashery, Valerie A. Schroeder, 2012, ACS chemical neuroscience.

MECHANISM OF TURNOVER OF IMIPENEM BY THE TEM BETA -LACTAMASE REVISITED

S. Mobashery, P. Taibi, 1995 .

Inactivation of class A β-lactamases by clavulanic acid : the role of arginine-244 in a proposed nonconcerted sequence of events

Eric M. Billings, S. Mobashery, E. Billings, 1993 .

Structural basis for progression toward the carbapenemase activity in the GES family of β-lactamases.

Malika Kumarasiri, S. Mobashery, M. Tóth, 2012, Journal of the American Chemical Society.

Cytoplasmic-Membrane Anchoring of a Class A β-Lactamase and Its Capacity in Manifesting Antibiotic Resistance

S. Mobashery, S. Vakulenko, M. Suvorov, 2007, Antimicrobial Agents and Chemotherapy.

Ab initio QM/MM study of class A beta-lactamase acylation: dual participation of Glu166 and Lys73 in a concerted base promotion of Ser70.

Samy O Meroueh, H. Schlegel, S. Meroueh, 2005, Journal of the American Chemical Society.

Three decades of the class A beta-lactamase acyl-enzyme.

S. Mobashery, J. Fisher, Jed F Fisher, 2009, Current protein & peptide science.

X-ray structure of the Asn276Asp variant of the Escherichia coli TEM-1 beta-lactamase: direct observation of electrostatic modulation in resistance to inactivation by clavulanic acid.

S. Cabantous, J. Samama, S. Mobashery, 1999, Biochemistry.

Facilitation of the .DELTA.2 .fwdarw. .DELTA.1 pyrroline tautomerization of carbapenem antibiotics by the highly conserved arginine-244 of class A .beta.-lactamases during the course of turnover

S. Mobashery, G. Zafaralla, 1992 .

Identification of Products of Inhibition of GES-2 β-Lactamase by Tazobactam by X-ray Crystallography and Spectrometry*

S. Mobashery, M. Tóth, Clyde A. Smith, 2011, The Journal of Biological Chemistry.

Activation of BlaR1 Protein of Methicillin-resistant Staphylococcus aureus, Its Proteolytic Processing, and Recovery from Induction of Resistance*

S. Mobashery, M. Tóth, M. Champion, 2011, The Journal of Biological Chemistry.

Lysine N(zeta)-decarboxylation in the BlaR1 protein from Staphylococcus aureus at the root of its function as an antibiotic sensor.

S. Mobashery, J. Cha, 2007, Journal of the American Chemical Society.

X-ray crystal structure of the acylated beta-lactam sensor domain of BlaR1 from Staphylococcus aureus and the mechanism of receptor activation for signal transduction.

C. Schulze-Briese, H. Schlegel, C. Birck, 2004, Journal of the American Chemical Society.

A practical synthesis of nitrocefin.

S. Mobashery, Mijoon Lee, D. Hesek, 2005, The Journal of organic chemistry.

Synthetic peptidoglycan substrates for penicillin-binding protein 5 of Gram-negative bacteria.

S. Mobashery, S. Vakulenko, Mijoon Lee, 2004, The Journal of organic chemistry.

Antibacterials as wonder drugs and how their effectiveness is being compromised

L. Kotra, L. Mourey, J. Samama, 2002 .

Turnover Chemistry and Structural Characterization of the Cj0843c Lytic Transglycosylase of Campylobacter jejuni.

V. Kumar, S. Mobashery, Jun Lin, 2021, Biochemistry.

Mechanism of the Escherichia coli MltE lytic transglycosylase, the cell-wall-penetrating enzyme for Type VI secretion system assembly

David A. Dik, J. Hermoso, Malika Kumarasiri, 2018, Scientific Reports.

1-(t-Butoxycarbonyl)imidazole

S. Mobashery, I. Grapsas, 2001 .

Water-Soluble MMP-9 Inhibitor Reduces Lesion Volume after Severe Traumatic Brain Injury.

B. N. Tomlinson, M. Suckow, Z. Gu, 2015, ACS chemical neuroscience.

Design and characterization of a metalloproteinase inhibitor-tethered resin for the detection of active MMPs in biological samples.

W. Sakr, S. Meroueh, R. Fridman, 2006, Chemistry & biology.

Potent Mechanism-based Inhibitors for Matrix Metalloproteinases*

M. Bernardo, R. Fridman, S. Mobashery, 2005, Journal of Biological Chemistry.

Cleavage at the stem region releases an active ectodomain of the membrane type 1 matrix metalloproteinase.

W. Sakr, S. Meroueh, R. Fridman, 2005, The Biochemical journal.

Design, Synthesis, and Characterization of Potent, Slow-binding Inhibitors That Are Selective for Gelatinases*

M. Bernardo, R. Fridman, S. Mobashery, 2002, The Journal of Biological Chemistry.

X-ray Absorption Studies of Human Matrix Metalloproteinase-2 (MMP-2) Bound to a Highly Selective Mechanism-based Inhibitor

L. Kotra, M. Bernardo, R. Fridman, 2001, The Journal of Biological Chemistry.

N-Glycosylation pattern of the zymogenic form of human matrix metalloproteinase-9.

L. Kotra, R. Fridman, S. Mobashery, 2002, Bioorganic chemistry.

Insight into the complex and dynamic process of activation of matrix metalloproteinases.

L. Kotra, H. Schlegel, Y. Shimura, 2001, Journal of the American Chemical Society.

Structure-Activity Relationship for Thiirane-Based Gelatinase Inhibitors.

Malika Kumarasiri, S. Mobashery, M. Tóth, 2012, ACS medicinal chemistry letters.

Chapter 10:Thiirane Class of Gelatinase Inhibitors as a Privileged Template that Crosses the Blood–Brain Barrier

S. Mobashery, Mayland Chang, Major Gooyit, 2015 .

Characterization of a selective inhibitor for matrix metalloproteinase-8 (MMP-8)

Hualiang Pi, S. Mobashery, Derong Ding, 2014 .

Matrix metalloproteinase 2 inhibition: combined quantum mechanics and molecular mechanics studies of the inhibition mechanism of (4-phenoxyphenylsulfonyl)methylthiirane and its oxirane analogue.

Thom Vreven, Peng Tao, H. Schlegel, 2009, Biochemistry.

Properties of analogues of an intermediate in the process of mechanism-based inactivation of carboxypeptidase A.

S. Mobashery, S. Dakoji, Y. J. Cho, 1996, Bioorganic & medicinal chemistry.

Crystallographic and computational insight on the mechanism of zinc-ion-dependent inactivation of carboxypeptidase a by 2-benzyl-3-iodopropanoate.

Irina Massova, I. Massova, S. Mobashery, 1996 .

Why clinically used tazobactam and sulbactam are poor inhibitors of OXA-10 beta-lactamase: Raman crystallographic evidence.

P. Carey, Benlian Wang, S. Mobashery, 2008, Biochemistry.

Structural Basis of the Heterodimer Formation between Cell Shape-Determining Proteins Csd1 and Csd2 from Helicobacter pylori

S. Suh, Soon-jong Kim, S. Mobashery, 2016, PloS one.

Lytic transglycosylase MltB of Escherichia coli and its role in recycling of peptidoglycan strands of bacterial cell wall.

S. Mobashery, Mijoon Lee, D. Hesek, 2008, Journal of the American Chemical Society.

Structural Insights into the Catalytic Domains of Human Matrix Metalloprotease-2 and Human Matrix Metalloprotease-9: Implications for Substrate Specificities

I. Massova, R. Fridman, S. Mobashery, 1997 .

Structural insight into the binding motifs for the calcium ion and the non-catalytic zinc in matrix metalloproteases.

L. Kotra, I. Massova, S. Mobashery, 1998, Bioorganic & medicinal chemistry letters.

Disruption of Allosteric Response as an Unprecedented Mechanism of Resistance to Antibiotics

J. Hermoso, C. Carrasco-López, S. Mobashery, 2014, Journal of the American Chemical Society.

Hydrolysis of ATP by Aminoglycoside 3′-Phosphotransferases

Honggao Yan, S. Mobashery, Choonkeun Kim, 2006, Journal of Biological Chemistry.

MMP-9 inhibitors impair learning in spontaneously hypertensive rats

Jeffrey F. Thompson, S. Mobashery, G. Rosenberg, 2018, PloS one.

Synthesis of a fragment of bacterial cell wall.

S. Mobashery, Mijoon Lee, D. Hesek, 2004, The Journal of organic chemistry.

Structural basis of the Escherichi coli outer-membrane permeability

Nabil A. Amro, Kapila Wadu-Mesthrige, Lakshmi P. Kotra, 1999, Photonics West - Biomedical Optics.

Expression of active matrix metalloproteinase‐9 as a likely contributor to the clinical failure of aclerastide in treatment of diabetic foot ulcers

M. Suckow, S. Mobashery, Mijoon Lee, 2018, European journal of pharmacology.

Penetration through Outer Membrane and Efflux Potential in Pseudomonas aeruginosa of Bulgecin A as an Adjuvant to β-Lactam Antibiotics

H. Zgurskaya, S. Mobashery, Choonkeun Kim, 2023, Antibiotics.

Horizontal-Acquisition of a Promiscuous Peptidoglycan-Recycling Enzyme Enables Aphids To Influence Symbiont Cell Wall Metabolism

N. Moran, M. Person, S. Mobashery, 2021, mBio.

Molecular basis of the final step of cell division in Streptococcus pneumoniae

F. Gago, I. Muñoz, R. Molina, 2023, Cell reports.

Bacterial Cell Wall: Morphology and Biochemistry

S. Mobashery, J. Fisher, Stefania De Benedetti, 2022, Practical Handbook of Microbiology.

A 1.2-A snapshot of the final step of bacterial cell wall biosynthesis.

Z. H. Li, L. Kotra, N. Silvaggi, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Mechanistic characterization of the bifunctional aminoglycoside-modifying enzyme AAC(3)-Ib/AAC(6')-Ib' from Pseudomonas aeruginosa.

S. Mobashery, Choonkeun Kim, D. Hesek, 2007, Biochemistry.

Synthesis of Muramyl‐δ‐Lactam in Spore Peptidoglycan of Clostridioides difficile

S. Mobashery, Choonkeun Kim, Mijoon Lee, 2023, Chembiochem : a European journal of chemical biology.

Targeting renal dipeptidase (dehydropeptidase I) for inactivation by mechanism-based inactivators.

S. Mobashery, Y. Wu, 1991, Journal of medicinal chemistry.

Resistance to β-Lactam Antibiotics and Its Mediation by the Sensor Domain of the Transmembrane BlaR Signaling Pathway in Staphylococcus aureus * 210

S. Meroueh, D. Golemi-Kotra, S. Mobashery, 2003, The Journal of Biological Chemistry.

Critical hydrogen bonding by serine 235 for cephalosporinase activity of TEM-1 beta-lactamase

S. Mobashery, S. Lerner, E. Manavathu, 1993, Antimicrobial Agents and Chemotherapy.

Molecular structures and dynamics of the stepwise activation mechanism of a matrix metalloproteinase zymogen: challenging the cysteine switch dogma.

S. Meroueh, R. Fridman, S. Mobashery, 2007, Journal of the American Chemical Society.

Structure of Csd3 from Helicobacter pylori, a cell shape-determining metallopeptidase

J. Yoon, S. Suh, Soon-jong Kim, 2015, Acta crystallographica. Section D, Biological crystallography.

Discoidin Domain Receptors: Unique Receptor Tyrosine Kinases in Collagen-mediated Signaling*

Paul H. Huang, R. Fridman, Malika Kumarasiri, 2013, The Journal of Biological Chemistry.

Discoidin Domain Receptors: Unique Receptor Tyrosine Kinases in Collagen-mediated

Paul H. Huang, R. Fridman, Malika Kumarasiri, 2013 .

Synergistic, collaterally sensitive β-lactam combinations suppress resistance in MRSA

Brent A. Biddy, G. Dantas, M. Suckow, 2015, Nature chemical biology.

Regulation of the Expression of the β-Lactam Antibiotic-Resistance Determinants in Methicillin-Resistant Staphylococcus aureus (MRSA)

S. Mobashery, C. Alfonso, J. R. Luque-Ortega, 2014, Biochemistry.

Activation for catalysis of penicillin-binding protein 2a from methicillin-resistant Staphylococcus aureus by bacterial cell wall.

S. Mobashery, Mijoon Lee, D. Hesek, 2005, Journal of the American Chemical Society.

Peptidoglycan reshaping by a noncanonical peptidase for helical cell shape in Campylobacter jejuni

S. Suh, S. Mobashery, H. Yoon, 2020, Nature Communications.

A mechanism-based inhibitor targeting the DD-transpeptidase activity of bacterial penicillin-binding proteins.

Sergei Vakulenko, S. Mobashery, S. Vakulenko, 2003, Journal of the American Chemical Society.

Matrix Metalloproteinase-14 as an Instigator of Fibrosis in Human Pterygium and Its Pharmacological Intervention.

J. Hovanesian, S. Mobashery, Mayland Chang, 2022, ACS pharmacology & translational science.

Activities of Oxadiazole Antibacterials against Staphylococcus aureus and Other Gram-Positive Bacteria

S. Mobashery, Choonkeun Kim, S. Ceballos, 2018, Antimicrobial Agents and Chemotherapy.

Design and synthesis of a structurally constrained aminoglycoside.

S. Mobashery, D. Hesek, Q. Shi, 2007, The Journal of organic chemistry.

Conjoint molecules of cephalosporins and aminoglycosides

S. Mobashery, S. Lerner, I. Grapsas, 2001, Archiv der Pharmazie.

Tethered bisubstrate derivatives as probes for mechanism and as inhibitors of aminoglycoside 3'-phosphotransferases.

L. Kotra, S. Mobashery, E. Azucena, 2000, The Journal of organic chemistry.

DFT studies of the ring-opening mechanism of SB-3CT, a potent inhibitor of matrix metalloproteinase 2.

Peng Tao, S. Mobashery, Jed F. Fisher, 2009, Organic Letters.

Host-guest chemistry of the peptidoglycan.

S. Mobashery, J. Fisher, 2010, Journal of medicinal chemistry.

Exploration of mild copper-mediated coupling of organotrifluoroborates in the synthesis of thiirane-based inhibitors of matrix metalloproteinases.

S. Mobashery, J. Fisher, R. Bouley, 2011, Bioorganic & medicinal chemistry letters.

Hyperbaric oxygen therapy accelerates wound healing in diabetic mice by decreasing active matrix metalloproteinase‐9

M. Suckow, S. Mobashery, Mijoon Lee, 2019, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

Metabolism of (4‐Phenoxyphenylsulfonyl)methylthiirane, a Selective Gelatinase Inhibitor

M. Suckow, S. Mobashery, Mijoon Lee, 2008, Chemical Biology and Drug Design.

A convenient synthesis of a selective gelatinase inhibitor as an antimetastatic agent.

S. Mobashery, Stephen M. Brown, I. Lim, 2004, The Journal of organic chemistry.

Strategy in inhibition of cathepsin B, a target in tumor invasion and metastasis.

S. Meroueh, S. Mobashery, Mijoon Lee, 2004, Journal of the American Chemical Society.

Transferase Versus Hydrolase: The Role of Conformational Flexibility in Reaction Specificity.

S. Light, Laty A. Cahoon, A. Halavaty, 2017, Structure.

Elucidation of the structure of the membrane anchor of penicillin-binding protein 5 of Escherichia coli.

J. Zajicek, S. Mobashery, J. Fisher, 2010, Journal of the American Chemical Society.

Transition State Stabilization

L. Kotra, S. Mobashery, 2002 .

Are matrix metalloproteinases relevant therapeutic targets for prostate cancer bone metastasis?

S. Mobashery, M. Cher, R. Bonfil, 2008, Current oncology.

Mechanism of anchoring of OmpA protein to the cell wall peptidoglycan of the gram‐negative bacterial outer membrane

Jung Hyun Song, Malika Kumarasiri, S. Mobashery, 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Faculty Opinions recommendation of Ultra-large library docking for discovering new chemotypes.

Shahriar Mobashery, S. Mobashery, 2019, Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature.

A Potent and Narrow-Spectrum Antibacterial against Clostridioides difficile Infection.

S. Mobashery, Jeshina Janardhanan, Derong Ding, 2023, Journal of medicinal chemistry.

Co-opting the cell wall in fighting methicillin-resistant Staphylococcus aureus: potent inhibition of PBP 2a by two anti-MRSA beta-lactam antibiotics.

S. Mobashery, S. Vakulenko, Mijoon Lee, 2008, Journal of the American Chemical Society.

Characterization of the β-Lactam Antibiotic Sensor Domain of the MecR1 Signal Sensor/Transducer Protein from Methicillin-Resistant Staphylococcus aureus†

S. Mobashery, S. Vakulenko, J. Cha, 2007 .

The Basis for Resistance to b -Lactam Antibiotics by Penicillin-Binding Protein 2a (PBP2a) of Methicillin-Resistant Staphylococcus aureus

S. Mobashery, S. Vakulenko, M. Suvorov, 2004 .

Three-dimensional QSAR analysis and design of new 1,2,4-oxadiazole antibacterials.

Malika Kumarasiri, Kiran V. Mahasenan, S. Mobashery, 2016, Bioorganic & medicinal chemistry letters.

Matrix metalloproteinase 2 (MMP2) inhibition: DFT and QM/MM studies of the deprotonation-initialized ring-opening reaction of the sulfoxide analogue of SB-3CT.

Peng Tao, H. Schlegel, Peng Tao, 2010, The journal of physical chemistry. B.

Lysine carboxylation in proteins: OXA-10 beta-lactamase.

J. Li, H. Schlegel, T. Vreven, 2005, Proteins.

Amber‐codon suppression for spatial localization and in vivo photoaffinity capture of the interactome of the Pseudomonas aeruginosa rare lipoprotein A lytic transglycosylase

S. Mobashery, J. Fisher, Luis F. Avila-Cobian, 2023, Protein science : a publication of the Protein Society.

Lytic transglycosylases: concinnity in concision of the bacterial cell wall

David A. Dik, S. Mobashery, J. Fisher, 2017, Critical reviews in biochemistry and molecular biology.

Structural characterization of lytic transglycosylase MltD of Pseudomonas aeruginosa, a target for the natural product bulgecin A.

S. Mobashery, M. Batuecas, Stefania De Benedetti, 2024, International journal of biological macromolecules.

A dual-action antibiotic that kills Clostridioides difficile vegetative cells and inhibits spore germination

S. Mobashery, Choonkeun Kim, Jeshina Janardhanan, 2023, Proceedings of the National Academy of Sciences of the United States of America.

Application of 2D-ITC to the Elucidation of the Enzymatic Mechanism of N-Acetylmuramic Acid/N-Acetylglucosamine Kinase (AmgK) from Pseudomonas aeruginosa.

S. Mobashery, Choonkeun Kim, Amr M. El-Araby, 2023, Biochemistry.

A Structural Dissection of the Active Site of the Lytic Transglycosylase MltE from Escherichia coli.

David A. Dik, J. Hermoso, Kiran V. Mahasenan, 2018, Biochemistry.

Muropeptide Binding and the X-ray Structure of the Effector Domain of the Transcriptional Regulator AmpR of Pseudomonas aeruginosa.

David A. Dik, L. Hellman, J. Hermoso, 2017, Journal of the American Chemical Society.

Lytic transglycosylases LtgA and LtgD perform distinct roles in remodeling, recycling and releasing peptidoglycan in Neisseria gonorrhoeae

S. Mobashery, Mijoon Lee, D. Hesek, 2016, Molecular Microbiology.

Crystal Structure of an Outer Membrane-Anchored Endolytic Peptidoglycan Lytic Transglycosylase (MltE) from Escherichia coli

J. Hermoso, Malika Kumarasiri, C. Carrasco-López, 2011 .

Catalytic process of anhydro-N-acetylmuramic acid kinase from Pseudomonas aeruginosa

J. Hermoso, S. Mobashery, J. Fisher, 2023, The Journal of biological chemistry.

Structure-activity relationship for the oxadiazole class of antibiotics.

M. Suckow, S. Mobashery, S. Vakulenko, 2015, Journal of medicinal chemistry.

Lytic transglycosylase MltB of Escherichia coli and its role in recycling of peptidoglycan strands of bacterial cell wall.

S. Mobashery, Mijoon Lee, D. Hesek, 2008, Journal of the American Chemical Society.

The Cell Shape-determining Csd6 Protein from Helicobacter pylori Constitutes a New Family of l,d-Carboxypeptidase

Nam Ki Lee, Sun Choi, J. Yoon, 2015, The Journal of Biological Chemistry.

Bacterial AmpD at the crossroads of peptidoglycan recycling and manifestation of antibiotic resistance.

S. Mobashery, Mijoon Lee, D. Hesek, 2009, Journal of the American Chemical Society.

Deciphering the Nature of Enzymatic Modifications of Bacterial Cell Walls

David A. Dik, S. Mobashery, Mijoon Lee, 2017, Chembiochem : a European journal of chemical biology.

Reactions of Escherichia coli TEM beta-lactamase with cephalothin and with C10-dipeptidyl cephalosporin esters.

S. Mobashery, M. Johnston, 1986, The Journal of biological chemistry.

Activation of BlaR1 Protein of Methicillin-resistant Staphylococcus aureus, Its Proteolytic Processing, and Recovery from Induction of Resistance*

S. Mobashery, M. Tóth, M. Champion, 2011, The Journal of Biological Chemistry.

β-Lactams from the Ocean

S. Mobashery, J. Fisher, 2023, Marine drugs.