J. Arch

J. Arch, S. Wilson, 1996, International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity.

Down-regulation of orexin gene expression by severe obesity in the rats: studies in Zucker fatty and zucker diabetic fatty rats and effects of rosiglitazone.

X. Cai, G. Williams, J. R. Arch, 2000, Brain research. Molecular brain research.

Effects of (−)‐RO363 at human atrial β‐adrenoceptor subtypes, the human cloned β3‐adrenoceptor and rodent intestinal β3‐adrenoceptors

J. Arch, P. Molenaar, A. Kaumann, 1997 .

Effects of chronic murine and human leptin infusion on plasma leptin and corticosterone levels and energy balance in lean Zucker rats

J. Arch, M. Tadayyon, K. Al-Barazanji, 2001, Diabetes, obesity & metabolism.

Inhibitory action of the potassium channel opener BRL 38227 on agonist-stimulated phosphoinositide metabolism in bovine tracheal smooth muscle.

R. Challiss, J. Arch, N. Patel, 1992, Biochemical pharmacology.

beta(3)-Adrenoceptor agonists: potential, pitfalls and progress.

J. Arch, 2002, European journal of pharmacology.

Identification of a novel agonist of peroxisome proliferator-activated receptors alpha and gamma that may contribute to the anti-diabetic activity of guggulipid in Lep(ob)/Lep(ob) mice.

M. Cawthorne, J. Arch, B. Strongitharm, 2009, The Journal of nutritional biochemistry.

A new, highly selective murine peroxisome proliferator‐activated receptor δ agonist increases responsiveness to thermogenic stimuli and glucose uptake in skeletal muscle in obese mice

T. Willson, M. Cawthorne, J. R. Arch, 2011, Diabetes, obesity & metabolism.

Central exendin-4 infusion reduces body weight without altering plasma leptin in (fa/fa) Zucker rats.

J. Arch, M. Tadayyon, K. Al-Barazanji, 2000, Obesity research.

Improvement of glucose tolerance in Zucker diabetic fatty rats by long‐term treatment with the dipeptidyl peptidase inhibitor P32/98: comparison with and combination with rosiglitazone

T. Hoffmann, P. Heinke, P. Augstein, 2005, Diabetes, obesity & metabolism.

5-HT2A and 5-HT2C receptors as hypothalamic targets of developmental programming in male rats

A. Garfield, G. Yeo, S. Ozanne, 2016, Disease Models & Mechanisms.

An investigation of the β-adrenoceptor that mediates metabolic responses to the novel agonist BRL28410 in rat soleus muscle

Shelagh Wilson, R. Challiss, J. Arch, 1988 .

Orexins and feeding: special occasions or everyday occurrence?

Shelagh Wilson, R. Morris, J. Clapham, 2002, Regulatory Peptides.

Orexins and the treatment of obesity.

J. Arch, A. Haynes, D. Smart, 2002, European journal of pharmacology.

Prevention of diet-induced obesity and impaired glucose tolerance in rats following administration of leptin to their mothers.

J. Speakman, M. Cawthorne, J. Arch, 2007, American journal of physiology. Regulatory, integrative and comparative physiology.

following administration of leptin to their mothers

J. Speakman, M. Cawthorne, J. Arch, 2007 .

The role of substrate cycles in metabolic regulation.

E. Newsholme, J. Arch, B. Surholt, 1983, Biochemical Society transactions.

Orexins, feeding and the big picture

J. Arch, 2000, British Journal of Nutrition.

Evaluation of the novel potassium channel activator BRL 55834 as an inhaled bronchodilator in guinea-pigs and rats: comparison with levcromakalim and salbutamol.

J. Arch, D. Buckle, N. Bowring, 1994, Pulmonary pharmacology.

Effects of dexamethasone in a model of lung hyperresponsiveness in the rat

J. Arch, V. Piercy, R. Baker, 1993, Agents and Actions.

Evaluation of the potassium channel activator BRL 38227 as an inhaled bronchodilator in the guinea-pig: contrast with nifedipine and salbutamol.

J. Arch, G. Clarke, D. Buckle, 1991, Pulmonary pharmacology.

Hypoglycemia activates orexin neurons and selectively increases hypothalamic orexin-B levels: responses inhibited by feeding and possibly mediated by the nucleus of the solitary tract.

X. Cai, Shelagh Wilson, M. Evans, 2001, Diabetes.

Beta 3-adrenoceptors and the regulation of metabolism in adipose tissues.

J. Arch, S. Wilson, 1996, Biochemical Society transactions.

Hypothalamic orexin expression: modulation by blood glucose and feeding.

X. Cai, Shelagh Wilson, G. Williams, 1999, Diabetes.

The rate of substrate cycling between fructose 6-phosphate and fructose 1,6-bisphosphate in skeletal muscle from cold-exposed, hyperthyroid or acutely exercised rats.

E. Newsholme, J. Arch, R. Challis, 1985, The Biochemical journal.

Measurement of the rate of substrate cycling between fructose 6-phosphate and fructose 1,6-bisphosphate in skeletal muscle by using a single-isotope technique.

B. Crabtree, E. Newsholme, R. Challiss, 1984, The Biochemical journal.

Effects of isoprenaline, adrenaline and selective α1- and α2- adrenoceptor stimulation on hypoxic pulmonary vasoconstriction in rat isolated perfused lungs

J. Arch, V. Piercy, H. Smith, 1990 .

Targeting thermogenesis and related pathways in anti-obesity drug discovery.

J. Clapham, J. Arch, 2011, Pharmacology & therapeutics.

Do low‐affinity states of β‐adrenoceptors have roles in physiology and medicine?

J. Arch, 2004 .

Ciglitazone is not itself thermogenic but increases the potential for thermogenesis in lean mice

J. Arch, S. Wilson, P. Thurlby, 1987, Bioscience reports.

Effect of some hormones on the rate of the triacylglycerol/fatty-acid substrate cycle in adipose tissue of the mouse in vivo

E. Newsholme, J. Arch, B. Brooks, 1983, Bioscience reports.

Effects of hormones on the rate of the triacylglycerol/fatty acid substrate cycle in adipocytes and epididymal fat cells (1982) FEBS Letters 146, 327–330.

E. Newsholme, J. Arch, B. Brooks, 1982 .

β2-adrenoceptor agonists can both stimulate and inhibit glucose uptake in mouse soleus muscle through ligand-directed signalling

M. Cawthorne, J. Arch, C. Stocker, 2013, Naunyn-Schmiedeberg's Archives of Pharmacology.

The rate of substrate cycling between fructose 6-phosphate and fructose 1,6-bisphosphate in skeletal muscle.

E. Newsholme, R. Challiss, J. Arch, 1984, The Biochemical journal.

Genetically obese C57BL/6 ob/ob mice respond normally to sympathomimetic compounds.

J. Arch, S. Wilson, P. Thurlby, 1984, Life sciences.

Inhibition of Cyclic Nucleotide Phosphodiesterase by Derivatives of 1, 3‐Bis(cyclopropylmethyl)xanthine.

J. Arch, K. Murray, K. Foster, 2010 .

Inhibition of cyclic nucleotide phosphodiesterase by derivatives of 1,3-bis(cyclopropylmethyl)xanthine.

J. Arch, K. Murray, K. Foster, 1994, Journal of medicinal chemistry.

Relaxant activity of 6-cyano-2,2-dimethyl-2H-1-benzopyran-4-carboxamides and -thiocarboxamides and their analogues in guinea pig trachealis.

J. Arch, A. Faller, K. Foster, 1991, Journal of medicinal chemistry.

Synthesis and smooth muscle relaxant activity of a new series of potassium channel activators: 3-amido-1,1-dimethylindan-2-ols.

J. Arch, C. Edge, J. Tedder, 1991, Journal of medicinal chemistry.

Substrate supply for thermogenesis induced by the beta-adrenoceptor agonist BRL 26830A.

J. Arch, S. Wilson, P. Thurlby, 1987, Canadian journal of physiology and pharmacology.

Activities and some properties of 5'-nucleotidase, adenosine kinase and adenosine deaminase in tissues from vertebrates and invertebrates in relation to the control of the concentration and the physiological role of adenosine.

E. Newsholme, J. Arch, 1978, The Biochemical journal.

The control of the metabolism and the hormonal role of adenosine.

E. Newsholme, J. Arch, 1978, Essays in biochemistry.

Relaxant effects of the potassium channel activators BRL 38227 and pinacidil on guinea-pig and human airway smooth muscle, and blockade of their effects by glibenclamide and BRL 31660.

J. Arch, D. Shaw, K. Foster, 1993, Pulmonary pharmacology.

Evaluation of the potassium channel activator cromakalim (BRL 34915) as a bronchodilator in the guinea‐pig: comparison with nifedipine

J. Arch, J. Arch, G. Clarke, 1988, British journal of pharmacology.

Expression of uncoupling protein mRNA in thermogenic or weakly thermogenic brown adipose tissue. Evidence for a rapid beta-adrenoreceptor-mediated and transcriptionally regulated step during activation of thermogenesis.

L. Pénicaud, J. Arch, D. Ricquier, 1986, The Journal of biological chemistry.

Activities and some properties of adenylate cyclase and phosphodiesterase in muscle, liver and nervous tissues from vertebrates and invertebrates in relation to the control of the concentration of adenosine 3':5'-cyclic monophosphate.

E. Newsholme, J. Arch, 1976, The Biochemical journal.

Effect of Rb+ on cromakalim-induced relaxation and ion fluxes in guinea pig trachea.

J. Arch, D. Shaw, K. Foster, 1992, European journal of pharmacology.

Male mice that lack the G-protein-coupled receptor GPR41 have low energy expenditure and increased body fat content

M. Cawthorne, J. Arch, M. Bellahcene, 2012, British Journal of Nutrition.

Interactions Between Leptin and Hypothalamic Neuropeptide Y Neurons in the Control of Food Intake and Energy Homeostasis in the Rat

Shelagh Wilson, J. Arch, R. Buckingham, 1997, Diabetes.

Detection of thermogenesis in rodents in response to anti-obesity drugs and genetic modification

J. Arch, P. Trayhurn, 2013, Front. Physiol..

Developmental programming of appetite and growth in male rats increases hypothalamic serotonin (5-HT)5A receptor expression and sensitivity

G. Yeo, S. Ozanne, L. Heisler, 2020, International Journal of Obesity.

5-HT2A and 5-HT2C receptors as hypothalamic targets of developmental programming in male rats

A. Garfield, G. Yeo, S. Ozanne, 2016, Development.

Stimulation of glucose uptake in murine soleus muscle and adipocytes by 5-(4-phenoxybutoxy)psoralen (PAP-1) may be mediated by Kv1.5 rather than Kv1.3

M. Cawthorne, J. Arch, K. Langlands, 2014, PeerJ.

Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior.

S. Carr, D. Bergsma, N. Elshourbagy, 1998, Cell.

Thermogenesis and related metabolic targets in anti-diabetic therapy.

J. Arch, 2011, Handbook of experimental pharmacology.

The discovery of drugs for obesity, the metabolic effects of leptin and variable receptor pharmacology: perspectives from β3-adrenoceptor agonists

J. Arch, 2008, Naunyn-Schmiedeberg's Archives of Pharmacology.

The β3-Adrenergic System and β3-Adrenergic Agonists

J. Arch, 2001, Reviews in Endocrine and Metabolic Disorders.

Differential distribution of orexin-A and orexin-B immunoreactivity in the rat brain and spinal cord☆

Shelagh Wilson, R. Morris, D. Cutler, 1999, Peptides.

Modulation of susceptibility to weight gain and insulin resistance in low birthweight rats by treatment of their mothers with leptin during pregnancy and lactation

J. Seckl, S. Glund, M. Sennitt, 2004, International Journal of Obesity.

Comparison of potential preventive effects of pomegranate flower, peel and seed oil on insulin resistance and inflammation in high-fat and high-sucrose diet-induced obesity mice model

M. Cawthorne, J. Arch, M. Zaibi, 2016, Archives of physiology and biochemistry.

Effects of single and chronic intracerebroventricular administration of the orexins on feeding in the rat

Shelagh Wilson, J. Arch, R. Buckingham, 1999, Peptides.

E(cid:128)ects of ( (cid:55) )-RO363 at human atrial (cid:98) -adrenoceptor subtypes, the human cloned (cid:98) 3 -adrenoceptor and rodent intestinal (cid:98) 3 -adrenoceptors

J. Arch, P. Molenaar, A. Kaumann, 1997 .

Acute effects of a beta-adrenoceptor agonist (BRL 26830A) on rat brown-adipose-tissue mitochondria. Increased GDP binding and GDP-sensitive proton conductance without changes in the concentration of uncoupling protein.

J. Arch, P. Trayhurn, S. Wilson, 1988, The Biochemical journal.

High fat-fed GPR55 null mice display impaired glucose tolerance without concomitant changes in energy balance or insulin sensitivity but are less responsive to the effects of the cannabinoids rimonabant or Δ(9)-tetrahydrocannabivarin on weight gain

J. Arch, C. Stocker, M. Zaibi, 2020, PeerJ.

The rat lipolytic beta-adrenoceptor: studies using novel beta-adrenoceptor agonists.

M. Sennitt, J. Arch, V. Piercy, 1984, European journal of pharmacology.

Anti-hyperglycaemic action of BRL 26830, a novel beta-adrenoceptor agonist, in mice and rats.

M. Sennitt, M. Cawthorne, J. Arch, 1985, Biochemical pharmacology.

35th Annual meeting of the European Association for the Study of Diabetes. Brussels, Belgium, 28 September-2 October, 1999. Abstracts.

Thomas J. Smith, B. M. Rasmussen, V. C. Phan, 1999, Diabetologia.

Sympathetic and hormonal regulation of brown adipose tissue thermogenesis.

J. Arch, S. Wilson, P. Thurlby, 1986, Biochemical Society transactions.

Preventive effects of Salvia officinalis leaf extract on insulin resistance and inflammation in a model of high fat diet-induced obesity in mice that responds to rosiglitazone

J. Arch, M. Zaibi, M. Hammami, 2018, PeerJ.

Preventive effects of salvia officinalis leaf extract on insulin resistance and inflammation, in high fat diet-induced-obesity mice model

J. Arch, M. Zaibi, M. Hammami, 2017 .

Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function

Robin J. W. Willows, Parvathy E. Harikumar, Nathan R. Qi, 2016, Cell Metabolism.

A simple apparatus for comparative measurements of energy expenditure in human subjects: the thermic effect of caffeine.

M. Hollands, M. Cawthorne, J. Arch, 1981, The American journal of clinical nutrition.

The inhibitory effects of cromakalim and its active enantiomer BRL 38227 against various agonists in guinea pig and human airways: comparison with pinacidil and verapamil.

J. Arch, J. Ward, D. Shaw, 1992, Journal of Pharmacology and Experimental Therapeutics.

Relaxant activity of 4-amido-3,4-dihydro-2H-1-benzopyran-3-ols and 4-amido-2H-1-benzopyrans on guinea pig isolated trachealis.

J. Arch, J. Tedder, D. G. Smith, 1990, Journal of medicinal chemistry.

Beta 3 and atypical beta-adrenoceptors.

J. Arch, A. Kaumann, 1993, Medicinal research reviews.

The effects of sarcolipin over-expression in mouse skeletal muscle on metabolic activity

M. Cawthorne, J. Arch, N. Smyth, 2015, Archives of biochemistry and biophysics.

Insulin stimulates pancreatic-duodenal homoeobox factor-1 (PDX1) DNA-binding activity and insulin promoter activity in pancreatic beta cells.

K. Docherty, J. Arch, H. Wu, 1999, The Biochemical journal.

Influencing energy expenditure and substrate utilisation

J. Clapham, J. Arch, 2008 .

Effects of intracerebroventricular infusion of leptin in obese Zucker rats.

J. Arch, A. Haynes, D. Mossakowska, 1997, Obesity research.

ob gene expression and secretion of leptin following differentiation of rat preadipocytes to adipocytes in primary culture.

W. Rees, J. Arch, N. Hoggard, 1997, Biochemical and biophysical research communications.

Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function

Robin J. W. Willows, Parvathy E. Harikumar, Nathan R. Qi, 2016, Cell metabolism.

Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function

Robin J. W. Willows, Parvathy E. Harikumar, Nathan R. Qi, 2016, Cell Metabolism.

Challenges in β3-adrenoceptor agonist drug development

J. Arch, 2011, Therapeutic Advances in Endocrinology and Metabolism.

Leanness in postnatally nutritionally programmed rats is associated with increased sensitivity to leptin and a melanocortin receptor agonist, and decreased sensitivity to neuropeptide Y

Claire J. Stocker, Edward T. Wargent, S. Ozanne, 2011, International Journal of Obesity.

Do low-affinity states of beta-adrenoceptors have roles in physiology and medicine?

J. Arch, 2004, British journal of pharmacology.

Effects of (-)-RO363 at human atrial beta-adrenoceptor subtypes, the human cloned beta 3-adrenoceptor and rodent intestinal beta 3-adrenoceptors.

J. Arch, P. Molenaar, A. Kaumann, 1997, British journal of pharmacology.