Y. Kozutsumi

发表

Down-regulation of caveolin-1 in mouse Lewis lung cancer P29 is a causal factor for the malignant properties in a high-metastatic subline.

Kazuro Furukawa, T. Urano, Qing Zhang, 2006, Oncology reports.

Cholesterol-dependent Formation of GM1 Ganglioside-bound Amyloid β-Protein, an Endogenous Seed for Alzheimer Amyloid*

Y. Kozutsumi, K. Yanagisawa, K. Matsuzaki, 2001, The Journal of Biological Chemistry.

Interaction between amyloid β‐protein aggregates and membranes

Y. Kozutsumi, K. Matsuzaki, Y. Yano, 2004 .

Ribosomal protein uS7/Rps5 serine-223 in protein kinase-mediated phosphorylation and ribosomal small subunit maturation

H. Takematsu, M. Kitabatake, M. Ohno, 2018, Scientific Reports.

In vivo role of aldehyde reductase.

T. Soga, N. Taniguchi, J. Fujii, 2012, Biochimica et biophysica acta.

Anomalous expression of Thy1 (CD90) in B-cell lymphoma cells and proliferation inhibition by anti-Thy1 antibody treatment.

K. Honke, Y. Kozutsumi, N. Kotani, 2010, Biochemical and biophysical research communications.

Synthetic glycan ligand excludes CD22 from antigen receptor-containing lipid rafts.

H. Takematsu, T. Adachi, T. Tsubata, 2007, Biochemical and biophysical research communications.

Hypoxic culture induces expression of sialin, a sialic acid transporter, and cancer-associated gangliosides containing non-human sialic acid on human cancer cells.

H. Takematsu, R. Kannagi, Jun Yin, 2006, Cancer research.

Identification of immunoglobulin heavy chain binding protein as glucose-regulated protein 78 on the basis of amino acid sequence, immunological cross-reactivity, and functional activity

J. Sambrook, M. Gething, C. Slaughter, 1989, Journal of Cell Science.

Interactions of amyloid beta-protein with various gangliosides in raft-like membranes: importance of GM1 ganglioside-bound form as an endogenous seed for Alzheimer amyloid.

Y. Kozutsumi, K. Yanagisawa, K. Matsuzaki, 2002, Biochemistry.

Human B-lymphocytes Express α2-6-Sialylated 6-Sulfo-N-acetyllactosamine Serving as a Preferred Ligand for CD22/Siglec-2*

H. Takematsu, R. Kannagi, Y. Kozutsumi, 2007, Journal of Biological Chemistry.

Correlation Index-Based Responsible-Enzyme Gene Screening (CIRES), a Novel DNA Microarray-Based Method for Enzyme Gene Involved in Glycan Biosynthesis

H. Takematsu, G. Tsujimoto, Y. Okuno, 2007, PloS one.

Identification and characterization of functional domains in a mixed lineage kinase LZK

Y. Kozutsumi, S. Oka, T. Kawasaki, 2001, FEBS letters.

Synthesis and binding analysis of unique AG2 pentasaccharide to human Siglec-2 using NMR techniques.

H. Takematsu, Y. Yamaguchi, S. Hanashima, 2010, Bioorganic & medicinal chemistry.

Molecular Cloning of Cytidine Monophospho-N-acetylneuraminic Acid Hydroxylase. REGULATION OF SPECIES- AND TISSUE-SPECIFIC EXPRESSION OF N-GLYCOLYLNEURAMINIC ACID (*)

H. Kawasaki, H. Takematsu, Y. Kozutsumi, 1995, The Journal of Biological Chemistry.

The Molecular Basis for the Absence ofN-Glycolylneuraminic Acid in Humans*

Y. Kozutsumi, A. Suzuki, A. Irie, 1998, The Journal of Biological Chemistry.

Association of GPI-Anchored Protein TAG-1 with Src-Family Kinase Lyn in Lipid Rafts of Cerebellar Granule Cells

Y. Kozutsumi, Tadashi Yamamoto, A. Oohira, 2002, Neurochemical Research.

Structures of Oligomannoside Chains of α-Mannosidase from Porcine Kidney

Y. Kozutsumi, J. Vliegenthart, H. Halbeek, 1986 .

Functional Evaluation of Activation-dependent Alterations in the Sialoglycan Composition of T Cells*

H. Takematsu, Yoshinobu Kano, T. Tsubata, 2013, The Journal of Biological Chemistry.

Sli2 (Ypk1), a Homologue of Mammalian Protein Kinase SGK, Is a Downstream Kinase in the Sphingolipid-Mediated Signaling Pathway of Yeast

H. Takematsu, K. Mori, Yidi Sun, 2000, Molecular and Cellular Biology.

Disturbance of Sphingolipid Biosynthesis Abrogates the Signaling of Mss4, Phosphatidylinositol-4-phosphate 5-Kinase, in Yeast*

H. Takematsu, Y. Kozutsumi, T. Yamaji, 2005, Journal of Biological Chemistry.

Synthesis of biotinylated sialoside to probe CD22–ligand interactions

H. Takematsu, Kozo Watanabe, T. Tsubata, 2009 .

Dual Roles of Sphingolipids in Signaling of the Escape from and Onset of Apoptosis in a Mouse Cytotoxic T-cell Line, CTLL-2 (*)

Y. Sun, Yidi Sun, Y. Miyake, 1996, The Journal of Biological Chemistry.

CD22 serves as a receptor for soluble IgM

H. Takematsu, M. Wabl, M. Fujimoto, 2012, European journal of immunology.

Participation of cytochrome b5 in CMP-N-acetylneuraminic acid hydroxylation in mouse liver cytosol.

Y. Kozutsumi, A. Suzuki, T. Yamakawa, 1990, Journal of biochemistry.

Reaction mechanism underlying CMP-N-acetylneuraminic acid hydroxylation in mouse liver: formation of a ternary complex of cytochrome b5, CMP-N-acetylneuraminic acid, and a hydroxylation enzyme.

H. Takematsu, Y. Kozutsumi, A. Suzuki, 1994, Journal of biochemistry.

Differential CXCR4 expression and function in subpopulations of the feline lymphoma cell line 3201 susceptible to feline immunodeficiency virus

Y. Kozutsumi, A. Tanabe-Tochikura, T. Tochikura, 2010, Journal of feline medicine and surgery.

Wheat germ agglutinin stains dispersed post‐golgi vesicles after treatment with the cytokinesis inhibitor psychosine

H. Takematsu, A. Yamamoto, Y. Kozutsumi, 2008, Journal of cellular physiology.

The requirement for the hydrophobic motif phosphorylation of Ypk1 in yeast differs depending on the downstream events, including endocytosis, cell growth, and resistance to a sphingolipid biosynthesis inhibitor, ISP-1.

H. Takematsu, Yidi Sun, Y. Kozutsumi, 2005, Archives of biochemistry and biophysics.

Orm protein phosphoregulation mediates transient sphingolipid biosynthesis response to heat stress via the Pkh-Ypk and Cdc55-PP2A pathways

Chao Zhang, K. Shokat, H. Takematsu, 2012, Molecular biology of the cell.

Oligosaccharides on cathepsin D from porcine spleen.

Y. Kozutsumi, J. Vliegenthart, Y. Nakao, 1984, Archives of biochemistry and biophysics.

Formation of a membrane-active form of amyloid beta-protein in raft-like model membranes.

Y. Kozutsumi, K. Matsuzaki, S. Nishimoto, 2003, Biochemical and biophysical research communications.

Induction of apoptosis by fumonisin B1 in HT29 cells is mediated by the accumulation of endogenous free sphingoid bases.

A. Merrill, Y. Kozutsumi, P. C. Roberts, 1998, Toxicology and applied pharmacology.

Inhibition of Cytokinesis by a Lipid Metabolite, Psychosine

H. Takematsu, H. Sabe, A. Yamamoto, 2000, The Journal of cell biology.

Immunological Property of Antibodies against N-Glycolylneuraminic Acid Epitopes in Cytidine Monophospho–N-Acetylneuraminic Acid Hydroxylase-Deficient Mice

H. Takematsu, H. Ohdan, Y. Kozutsumi, 2010, The Journal of Immunology.

Sphingolipids involved in the induction of multinuclear cell formation.

H. Takematsu, Yidi Sun, Y. Kozutsumi, 2002, Biochimica et biophysica acta.

Induction of feline immunodeficiency virus from a chronically infected feline T-lymphocyte cell line.

Y. Kozutsumi, T. Tochikura, T. Hohdatsu, 2012, Research in veterinary science.

Antitumor activity of mannan-binding protein in vivo as revealed by a virus expression system: mannan-binding proteindependent cell-mediated cytotoxicity.

Y. Kozutsumi, S. Oka, T. Kawasaki, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Regulation of biosynthesis ofN-glycolylneuraminic acid-containing glycoconjugates: characterization of factors required for NADH-dependent cytidine 5′monophosphate-N-acetylneuraminic acid hydroxylation

H. Takematsu, Y. Kozutsumi, A. Suzuki, 1993, Glycoconjugate Journal.

Effects of exogenous β-galactosidase on cultured fibroblasts with β-galactosidase deficiency

Y. Kozutsumi, Y. Nakao, T. Kawasaki, 1987 .

Isolation and characterization of a receptor lectin specific for galactose/N-acetylgalactosamine from macrophages.

Y. Kozutsumi, T. Kawasaki, I. Yamashina, 1986, Carbohydrate research.

[The molecular basis for the absence of N-glycolylneuraminic acid in humans].

Y. Kozutsumi, A. Suzuki, A. Irie, 1998, Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme.

Physical and Functional Association of Glucuronyltransferases and Sulfotransferase Involved in HNK-1 Biosynthesis*

H. Takematsu, Yasuhiko Kizuka, Y. Kozutsumi, 2006, Journal of Biological Chemistry.

Biosynthesis of N-glycolylneuraminic acid-containing glycoconjugates. Purification and characterization of the key enzyme of the cytidine monophospho-N-acetylneuraminic acid hydroxylation system.

Y. Kozutsumi, A. Suzuki, T. Kawasaki, 1994, The Journal of biological chemistry.

Prediction of Glycan Structures from Glycosyltransferase Expression Profiles

M. Kanehisa, S. Goto, H. Takematsu, 2003 .

Cloning and functional expression of a novel glucuronyltransferase involved in the biosynthesis of the carbohydrate epitope HNK-1.

Y. Kozutsumi, K. Takio, S. Oka, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Isolation and characterization of a mannan-binding protein from rabbit serum.

Y. Kozutsumi, T. Kawasaki, I. Yamashina, 1978, Biochemical and biophysical research communications.

Molecular cloning of rabbit cytochrome b5 genes: evidence for the occurrence of two separate genes encoding the soluble and microsomal forms.

H. Takematsu, Y. Kozutsumi, A. Suzuki, 1992, Biochemical and biophysical research communications.

Isolation and characterization of a mannan-binding protein from rat liver.

Y. Kozutsumi, T. Kawasaki, I. Yamashina, 1981, The Journal of biological chemistry.

Aberrant expression of N-acetylglucosaminyltransferase-IVa and IVb (GnT-IVa and b) in pancreatic cancer.

Naoyuki Taniguchi, Eiji Miyoshi, J. Gu, 2006, Biochemical and biophysical research communications.

Isolation and characterization of the rabbit cytochrome b5 gene.

H. Takematsu, Y. Kozutsumi, A. Suzuki, 1996, DNA sequence : the journal of DNA sequencing and mapping.

Reconstitution of CMP-N-acetylneuraminic acid hydroxylation activity using a mouse liver cytosol fraction and soluble cytochrome b5 purified from horse erythrocytes.

H. Kawasaki, K. Suzuki, Y. Kozutsumi, 1991, Journal of biochemistry.

A naturally occurring 46-amino acid deletion of cytidine monophospho-N-acetylneuraminic acid hydroxylase leads to a change in the intracellular distribution of the protein

H. Takematsu, Y. Kozutsumi, A. Suzuki, 1996, Glycoconjugate Journal.

SLI1 (YGR212W) is a major gene conferring resistance to the sphingolipid biosynthesis inhibitor ISP-1, and encodes an ISP-1 N-acetyltransferase in yeast.

H. Takematsu, Yidi Sun, Y. Kozutsumi, 2004, The Biochemical journal.

Serine palmitoyltransferase is the primary target of a sphingosine-like immunosuppressant, ISP-1/myriocin.

Y. Miyake, Y. Kozutsumi, T. Kawasaki, 1995, Biochemical and biophysical research communications.

Germinal Center Marker GL7 Probes Activation-Dependent Repression of N-Glycolylneuraminic Acid, a Sialic Acid Species Involved in the Negative Modulation of B-Cell Activation

S. Itohara, H. Takematsu, G. Tsujimoto, 2007, Molecular and Cellular Biology.

Role of the collagen-like domain of the human serum mannan-binding protein in the activation of complement and the secretion of this lectin.

H. Kurata, Y. Kozutsumi, T. Kawasaki, 1993, Biochemical and biophysical research communications.

S. cerevisiae encodes an essential protein homologous in sequence and function to mammalian BiP

J. Sambrook, M. Gething, Y. Kozutsumi, 1989, Cell.

The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteins

J. Sambrook, M. Gething, Y. Kozutsumi, 1988, Nature.

Molecular Cloning and Functional Expression of a cDNA Encoding a New Member of Mixed Lineage Protein Kinase from Human Brain*

Y. Kozutsumi, S. Oka, J. Zanetta, 1997, The Journal of Biological Chemistry.

Fpk1/2 kinases regulate cellular sphingoid long-chain base abundance and alter cellular resistance to LCB elevation or depletion

H. Takematsu, Y. Kozutsumi, Mitsugu Shimobayashi, 2014, MicrobiologyOpen.

Interleukin-2-induced survival of natural killer (NK) cells involving phosphatidylinositol-3 kinase-dependent reduction of ceramide through acid sphingomyelinase, sphingomyelin synthase, and glucosylceramide synthase.

Y. Kozutsumi, H. Umehara, T. Kondo, 2004, Blood.

Structural and functional roles of the amino‐terminal region and collagen‐like domain of human serum mannan‐binding protein

Y. Kozutsumi, T. Kawasaki, Y. Yokota, 1996, Biochemistry and molecular biology international.

Identification of Ypk1 as a Novel Selective Substrate for Nitrogen Starvation-triggered Proteolysis Requiring Autophagy System and Endosomal Sorting Complex Required for Transport (ESCRT) Machinery Components*

H. Takematsu, Y. Kozutsumi, Mitsugu Shimobayashi, 2010, The Journal of Biological Chemistry.

Tropoelastin regulates chemokine expression in fibroblasts in Costello syndrome.

D. Tsuji, Reiko Fujinawa, Y. Kozutsumi, 2008, Biochemical and biophysical research communications.

Hypoxia induces adhesion molecules on cancer cells: A missing link between Warburg effect and induction of selectin-ligand carbohydrates.

K. Kumamoto, H. Takematsu, A. Taniguchi, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Quantitative Transcriptomic Profiling of Branching in a Glycosphingolipid Biosynthetic Pathway*

H. Takematsu, Y. Okuno, Yoshimasa Tanaka, 2011, The Journal of Biological Chemistry.

Psychosine-triggered endomitosis is modulated by membrane sphingolipids through regulation of phosphoinositide 4,5-bisphosphate production at the cleavage furrow

H. Takematsu, Toshihide Kobayashi, Y. Kozutsumi, 2016, Molecular biology of the cell.

Regulation of BiP Gene Expression by Cyclopentenone Prostaglandins through Unfolded Protein Response Element*

Y. Kozutsumi, A. Ichikawa, M. Negishi, 1996, The Journal of Biological Chemistry.

DNA Microarray in Glycobiology

H. Takematsu, Y. Kozutsumi, Harumi Yamamoto, 2008 .

Establishment of the culture model system that reflects the process of terminal differentiation of connective tissue‐type mast cells

H. Takematsu, G. Tsujimoto, Y. Okuno, 2008, FEBS letters.

A Unique CD45 Glycoform Recognized by the Serum Mannan-binding Protein in Immature Thymocytes (*)

Y. Kozutsumi, T. Kawasaki, K. Uemura, 1996, The Journal of Biological Chemistry.

Sphingosylphosphorylcholine and lysosulfatide have inverse regulatory functions in monocytic cell differentiation into macrophages.

H. Takematsu, Y. Kozutsumi, Hiroshi Yamamoto, 2011, Archives of biochemistry and biophysics.

Protective effect of N -glycan bisecting GlcNAc residues on β -amyloid production in Alzheimer’s disease

N. Taniguchi, S. Murayama, Y. Kozutsumi, 2009 .

N-Glycolylneuraminic Acid Deficiency in Mice: Implications for Human Biology and Evolution

A. Varki, H. Takematsu, A. Wynshaw-Boris, 2007, Molecular and Cellular Biology.

Renal expression of serum-type mannan-binding protein in rat.

H. Kurata, Y. Kozutsumi, S. Oka, 1997, European journal of biochemistry.

Characterization of Genes Conferring Resistance Against ISP-1/Myriocin-Induced Sphingolipid Depletion in Yeast

H. Takematsu, Y. Kozutsumi, 2006 .

Protective effect of N-glycan bisecting GlcNAc residues on beta-amyloid production in Alzheimer's disease.

N. Taniguchi, S. Murayama, Y. Kozutsumi, 2010, Glycobiology.

Dihydroceramide:sphinganine C-4-hydroxylation requires Des2 hydroxylase and the membrane form of cytochrome b5.

Y. Kozutsumi, A. Suzuki, T. Yubisui, 2006, The Biochemical journal.

GM1 ganglioside-mediated accumulation of amyloid beta-protein on cell membranes.

Masaki Wakabayashi, Takuma Okada, Katsumi Matsuzaki, 2005, Biochemical and biophysical research communications.

Structures of oligosaccharides on β-galactosidase from Aspergillus oryzae

J. Vliegenthart, Y. Kozutsumi, H. Halbeek, 1987 .

Neutral glycosphingolipids induce cell-cell aggregation of a variety of hematopoietic cell lines.

Y. Miyake, Y. Kozutsumi, T. Yamaji, 1997, European journal of biochemistry.

Structural studies on phosphorylated oligosaccharides derived from yeast mannan by 1H(31P) relayed spin-echo difference spectroscopy (RESED).

P. de Waard, Y. Kozutsumi, J. Vliegenthart, 1989, The Journal of biological chemistry.

CD22-antagonists with nanomolar potency: the synergistic effect of hydrophobic groups at C-2 and C-9 of sialic acid scaffold.

H. Takematsu, Kozo Watanabe, T. Tsubata, 2011, Bioorganic & medicinal chemistry.