N. Oku

N. Oku, T. Asai, Hiroyasu Toyota, 2017, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Formation of giant liposomes from lipids in chaotropic ion solutions

R. Macdonald, N. Oku, 1983 .

Differential effects of alkali metal chlorides on formation of giant liposomes by freezing and thawing and dialysis.

R. Macdonald, N. Oku, 1983, Biochemistry.

Activation of the serum response element and 12-O-tetradecanoylphorbol-13-acetate response element by the activated c-raf-1 protein in a manner independent of protein kinase C.

K. Kaibuchi, T. Yamamoto, Y. Takai, 1989, The Journal of biological chemistry.

Imaging Cell Trafficking

N. Oku, T. Asai, 2005 .

Challenge for oral delivery of middle-molecular drugs: Use of osmolarity-sensitive liposome as a drug carrier in the GI tract

M. Kataoka, S. Yamashita, N. Oku, 2020 .

Size-dependent induction of accelerated blood clearance phenomenon by repeated injections of polymeric micelles.

M. Yokoyama, K. Shiraishi, N. Oku, 2012, International journal of pharmaceutics.

Temperature-dependent transfer of amphotericin B from liposomal membrane of AmBisome to fungal cell membrane.

N. Oku, T. Asai, K. Shimizu, 2010, Journal of controlled release : official journal of the Controlled Release Society.

Particle size-dependent triggering of accelerated blood clearance phenomenon.

M. Yokoyama, N. Oku, Hiroyuki Koide, 2008, International journal of pharmaceutics.

Sulphatide binds to human and animal influenza A viruses, and inhibits the viral infection.

Y. Kawaoka, T. Ito, M. Kiso, 1996, The Biochemical journal.

Effect of serum protein binding on real-time trafficking of liposomes with different charges analyzed by positron emission tomography.

H. Tsukada, M. Endo, N. Oku, 1996, Biochimica et biophysica acta.

Proapoptotic action of p53-Tom5 in p53-resistant A549 human non-small cell lung cancer cells through direct mitochondrial dysfunction.

M. Mihara, N. Oku, T. Asai, 2011, Biological & pharmaceutical bulletin.

Engineering of Lipid Nanoparticles by the Multifunctionalization of the Surface with Amino Acid Derivatives for the Neutralization of a Target Toxic Peptide

Kazuhiro Saito, N. Oku, Hiroyuki Koide, 2020, Advanced Functional Materials.

Tyrosine Phosphorylation of β-Catenin and Plakoglobin Enhanced by Hepatocyte Growth Factor and Epidermal Growth Factor in Human Carcinoma Cells

K. Miyazawa, M. Takeichi, K. Takeuchi, 1994 .

Phototoxicity of coproporphyrin as a novel photodynamic therapy was enhanced by liposomalization.

N. Oku, N. Kanayama, Y. Sadzuka, 2008, Toxicology letters.

Current Status of siRNA Delivery Technology and siRNA Drug Development

N. Oku, T. Urakami, 2007 .

Suppression of tumor growth by novel peptides homing to tumor‐derived new blood vessels

N. Oku, T. Asai, K. Kurohane, 2002, FEBS letters.

Influence of manganese on the release of neurotransmitters in rat striatum

N. Sotogaku, N. Oku, A. Takeda, 2003, Brain Research.

Region-specific loss of zinc in the brain in pentylentetrazole-induced seizures and seizure susceptibility in zinc deficiency

N. Oku, A. Takeda, Hiromasa Itoh, 2006, Epilepsy Research.

Involvement of unusual glutamate release in kainate-induced seizures in zinc-deficient adult rats

N. Oku, A. Takeda, H. Tamano, 2005, Epilepsy Research.

Ameliorative effect of Yokukansan on social isolation-induced aggressive behavior of zinc-deficient young mice

N. Oku, A. Takeda, H. Tamano, 2010, Brain Research Bulletin.

Impairment of GABAergic neurotransmitter system in the amygdala of young rats after 4-week zinc deprivation

N. Oku, A. Takeda, Hiromasa Itoh, 2006, Neurochemistry International.

Zinc homeostasis in the hippocampus of zinc-deficient young adult rats

N. Oku, A. Takeda, H. Tamano, 2005, Neurochemistry International.

Responsiveness to kainate in young rats after 2-week zinc deprivation

N. Oku, A. Takeda, Hiromasa Itoh, 2006, Biometals.

Combination therapy with liposomal neuroprotectants and tissue plasminogen activator for treatment of ischemic stroke

N. Oku, Hiroyuki Koide, T. Asai, 2017, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Application and Utility of Liposomal Neuroprotective Agents and Biomimetic Nanoparticles for the Treatment of Ischemic Stroke

K. Kogure, N. Oku, T. Fukuta, 2022, Pharmaceutics.

Co-administration of liposomal fasudil and tissue plasminogen activator ameliorated ischemic brain damage in occlusion model rats prepared by photochemically induced thrombosis.

N. Oku, T. Asai, T. Fukuta, 2018, Biochemical and biophysical research communications.

Decoration of fibrinogen γ-chain peptide on adenosine diphosphate-encapsulated liposomes enhances binding of the liposomes to activated platelets.

N. Watanabe, S. Takeoka, N. Oku, 2011, International journal of pharmaceutics.

Biomembrane damage caused by exposure to multi-walled carbon nanotubes.

N. Oku, K. Shimizu, A. Hirose, 2013, The Journal of toxicological sciences.

Cell-penetrating peptide-conjugated lipid nanoparticles for siRNA delivery.

M. Nango, N. Oku, Ayaka Okamoto, 2014, Biochemical and biophysical research communications.

Usefulness of Liposomal Neuroprotectants for the Treatment of Ischemic Stroke

N. Oku, T. Asai, T. Fukuta, 2017 .

Liposomes Conjugated with a Pilot Molecule

N. Oku, K. Shimizu, 2019, Cancer Drug Delivery Systems Based on the Tumor Microenvironment.

Macrophage-targeted, enzyme-triggered fluorescence switch-on system for detection of embolism-vulnerable atherosclerotic plaques.

Y. Magata, N. Oku, K. Shimizu, 2019, Journal of controlled release : official journal of the Controlled Release Society.

Visualization of Sialidase Activity in Mammalian Tissues and Cancer Detection with a Novel Fluorescent Sialidase Substrate

K. Ikeda, N. Oku, K. Shimizu, 2014, PloS one.

Stress response caused by chronic alcohol intake in aged rat brain.

N. Oku, S. Okada, K. Unno, 2002, Alcoholism, clinical and experimental research.

Increase in basal level of Hsp70, consisting chiefly of constitutively expressed Hsp70 (Hsc70) in aged rat brain.

N. Oku, S. Okada, K. Unno, 2000, The journals of gerontology. Series A, Biological sciences and medical sciences.

Specific delivery of an immunosuppressive drug to splenic B cells by antigen-modified liposomes and its antiallergic effect

N. Oku, T. Asai, K. Shimizu, 2016, Journal of drug targeting.

Suppression of choroidal neovascularization by intravitreal injection of liposomal SU5416.

N. Oku, T. Asai, Y. Araki, 2011, Archives of ophthalmology.

Antiangiogenic cancer therapy using tumor vasculature-targeted liposomes encapsulating 3-(3,5-dimethyl-1H-pyrrol-2-ylmethylene)-1,3-dihydro-indol-2-one, SU5416.

N. Oku, T. Asai, K. Shimizu, 2008, Cancer letters.

Overexpression of the Csk homologous kinase (Chk tyrosine kinase) induces multinucleation: a possible role for chromosome-associated Chk in chromosome dynamics.

T. Suda, N. Oku, N. Yamaguchi, 2001, Journal of cell science.

Treatment of cerebral ischemia‐reperfusion injury with PEGylated liposomes encapsulating FK506

N. Oku, T. Asai, K. Shimizu, 2013, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Daily consumption of green tea catechin delays memory regression in aged mice

N. Oku, K. Unno, M. Hoshino, 2007, Biogerontology.

Elimination of zinc-65 from the brain under kainate-induced seizures

N. Oku, A. Takeda, Maki Hirate, 2004, Biometals.

Sequestering and inhibiting a vascular endothelial growth factor in vivo by systemic administration of a synthetic polymer nanoparticle

Y. Miura, Y. Hoshino, N. Oku, 2019, Journal of controlled release : official journal of the Controlled Release Society.

Rational designing of an antidote nanoparticle decorated with abiotic polymer ligands for capturing and neutralizing target toxins

Y. Hoshino, N. Oku, Hiroyuki Koide, 2017, Journal of controlled release : official journal of the Controlled Release Society.

Enhanced Susceptibility to Spontaneous Seizures of Noda Epileptic Rats by Loss of Synaptic Zn2+

N. Oku, A. Takeda, H. Tamano, 2013, PloS one.

Vulnerability to Seizures Induced by Potassium Dyshomeostasis in the Hippocampus in Aged Rats

N. Oku, A. Takeda, M. Ando, 2008 .

Increased gene expression by cationic liposomes (TFL-3) in lung metastases following intravenous injection.

N. Oku, T. Ishida, H. Kiwada, 2005, Biological & pharmaceutical bulletin.

Enhanced Active Targeting via Cooperative Binding of Ligands on Liposomes to Target Receptors

N. Oku, T. Asai, K. Shimizu, 2013, PloS one.

A novel DDS strategy, "dual-targeting", and its application for antineovascular therapy.

N. Oku, T. Asai, K. Shimizu, 2010, Cancer letters.

Imaging technology for the research and the development of DDS nanocarriers and nanomedicines

N. Oku, T. Urakami, 2008 .

Role of integrin αvβ3 in the early phase of liver metastasis: PET and IVM analyses

T. Kakiuchi, H. Tsukada, Y. Takada, 2004, Clinical & Experimental Metastasis.

Abnormal iron accumulation in the brain of neonatal hypotransferrinemic mice

J. Connor, N. Oku, A. Takeda, 2001, Brain Research.

Chemoprevention of tumor metastasis by liposomal beta-sitosterol intake.

N. Oku, Hiroyuki Koide, T. Asai, 2008, Biological & pharmaceutical bulletin.

Enhanced experimental tumor metastasis with age in senescence-accelerated mouse.

H. Tsukada, N. Oku, T. Asai, 2008, Biological & pharmaceutical bulletin.

Effects of tumor necrosis factor on cell growth and expression of transferrin receptors in human fibroblasts.

T. Hori, M. Tsujimoto, N. Oku, 1988, Cell structure and function.

Involvement of prostaglandin-producing pathway in the cytotoxic action of tumor necrosis factor.

K. Takeuchi, T. Hori, M. Tsujimoto, 1991, Cell structure and function.

Decline in glutathione peroxidase activity is a reason for brain senescence: consumption of green tea catechin prevents the decline in its activity and protein oxidative damage in ageing mouse brain

N. Oku, K. Unno, S. Asahina, 2007, Biogerontology.

Suppressive effect of green tea catechins on morphologic and functional regression of the brain in aged mice with accelerated senescence (SAMP10)

N. Oku, K. Unno, F. Takabayashi, 2004, Experimental Gerontology.

PET imaging of nobiletin based on a practical total synthesis.

N. Harada, H. Tsukada, N. Oku, 2011, Chemical communications.

Influence of iron-saturation of plasma transferrin in iron distribution in the brain

N. Sotogaku, N. Oku, A. Takeda, 2002, Neurochemistry International.

Design of synthetic polymer nanoparticles that inhibit glucose absorption from the intestine.

Y. Hoshino, N. Oku, Hiroyuki Koide, 2021, Biochemical and Biophysical Research Communications - BBRC.

Manganese concentration in mouse brain after intravenous injection

N. Sotogaku, N. Oku, A. Takeda, 2000, Journal of neuroscience research.

Liposomalization of hydroxyphenyl fluorescein as a reagent for detecting highly reactive oxygen species

N. Oku, Y. Sadzuka, I. Sugiyama, 2010 .

Therapeutic effect of Yokukansan on social isolation-induced aggressive behavior of zinc-deficient and pair-fed mice

N. Oku, A. Takeda, K. Ide, 2012, Brain Research Bulletin.

(-)-Epigallocatechin gallate inhibits membrane-type 1 matrix metalloproteinase, MT1-MMP, and tumor angiogenesis.

N. Oku, T. Asai, T. Akizawa, 2004, Cancer letters.

Inhibitory effect of green tea polyphenols on membrane-type 1 matrix metalloproteinase, MT1-MMP.

N. Oku, T. Asai, S. Yahara, 2003, Biological & pharmaceutical bulletin.

Therapeutic Silencing of Centromere Protein X Ameliorates Hyperglycemia in Zebrafish and Mouse Models of Type 2 Diabetes Mellitus

M. Shiota, N. Oku, Ayaka Okamoto, 2019, Front. Genet..

Hepatocyte growth factor and transforming growth factor-beta stimulate both cell growth and migration of human gastric adenocarcinoma cells.

K. Miyazawa, T. Hori, N. Kitamura, 1992, Cell structure and function.

Liposomal modification with uronate, which endows liposomes with long circulation in vivo, reduces the uptake of liposomes by J774 cells in vitro.

N. Oku, S. Okada, Y. Namba, 1992, Life sciences.

Tumor accumulation of novel RES-avoiding liposomes.

N. Oku, S. Okada, Y. Namba, 1992, Biochimica et biophysica acta.

Neuroprotection against cerebral ischemia/reperfusion injury by intravenous administration of liposomal fasudil.

N. Oku, Hiroyuki Koide, T. Asai, 2016, International journal of pharmaceutics.

Glucuronate-modified, long-circulating liposomes for the delivery of anticancer agents.

N. Oku, Y. Namba, 2005, Methods in enzymology.

Enhancement of anticancer activity in antineovascular therapy is based on the intratumoral distribution of the active targeting carrier for anticancer drugs.

H. Tsukada, N. Oku, T. Asai, 2006, Biological & pharmaceutical bulletin.

Antiangiogenic photodynamic therapy (PDT) by using long-circulating liposomes modified with peptide specific to angiogenic vessels.

N. Oku, T. Asai, Y. Takeuchi, 2005, Biochimica et biophysica acta.

Anti-neovascular therapy using novel peptides homing to angiogenic vessels

H. Tsukada, N. Oku, T. Asai, 2002, Oncogene.

Prostaglandins antagonize fibroblast proliferation stimulated by tumor necrosis factor.

T. Hori, M. Tsujimoto, N. Oku, 1991, Biochemical and biophysical research communications.

Ability of fibrinogen γ-derived dodecapeptides with different sequences to bind to rat platelets.

N. Watanabe, S. Takeoka, N. Oku, 2012, International journal of pharmaceutics.

A new interpretation of salicylic acid transport across the lipid bilayer: implications of pH-dependent but not carrier-mediated absorption from the gastrointestinal tract.

S. Yamashita, N. Oku, T. Nadai, 1998, The Journal of pharmacology and experimental therapeutics.

Anti-obesity effect of phosphatidylinositol on diet-induced obesity in mice.

N. Oku, T. Asai, K. Shimizu, 2010, Journal of agricultural and food chemistry.

Liposomal Amiodarone Augments Anti-arrhythmic Effects and Reduces Hemodynamic Adverse Effects in an Ischemia/Reperfusion Rat Model

I. Komuro, H. Asanuma, S. Sanada, 2013, Cardiovascular Drugs and Therapy.

Design and synthesis of high-avidity tetravalent glycoclusters as probes for Sambucus sieboldiana agglutinin and characterization of their binding properties.

E. Park, N. Oku, T. Asai, 2012, Bioconjugate chemistry.

Targeted Therapy for Acute Autoimmune Myocarditis with Nano-Sized Liposomal FK506 in Rats

Y. Sakata, H. Asanuma, S. Sanada, 2016, PloS one.

Prolonged targeting of ischemic/reperfused myocardium by liposomal adenosine augments cardioprotection in rats.

M. Sugimachi, N. Mochizuki, H. Asanuma, 2009, Journal of the American College of Cardiology.

In Vivo Quantitative Autoradiographic Analysis of Brain Muscarinic Receptor Occupancy by Antimuscarinic Agents for Overactive Bladder Treatment

S. Yamada, S. Nishiyama, T. Kakiuchi, 2008, Journal of Pharmacology and Experimental Therapeutics.

Suppression of GD1α ganglioside‐mediated tumor metastasis by liposomalized WHW‐peptide

N. Oku, T. Asai, N. Yamaguchi, 2000, FEBS letters.

DNA-strand breaks induced by dimethylarsinic acid, a metabolite of inorganic arsenics, are strongly enhanced by superoxide anion radicals.

N. Oku, S. Okada, K. Kawaguchi, 1995, Biological & pharmaceutical bulletin.

Arachidonic acid-selective cytosolic phospholipase A2 is crucial in the cytotoxic action of tumor necrosis factor.

K. Takeuchi, T. Hori, M. Tsujimoto, 1993, The Journal of biological chemistry.

Real-time PET analysis of metastatic tumor cell trafficking in vivo and its relation to adhesion properties.

T. Irimura, H. Tsukada, N. Oku, 1995, Biochimica et biophysica acta.

A new approach for drug discovery from glycobiology and phage-displayed peptide library technology.

N. Oku, T. Asai, K. Ogino, 2008, Biochimica et biophysica acta.

Anti-angiogenic activity and intracellular distribution of epigallocatechin-3-gallate analogs.

N. Oku, K. Shimizu, T. Asakawa, 2011, Biological & pharmaceutical bulletin.

Concise synthesis of catechin probes enabling analysis and imaging of EGCg.

M. Ohshima, K. Itoh, N. Oku, 2011, Chemical communications.

Release of glutamate and GABA in the hippocampus under zinc deficiency

N. Oku, A. Takeda, Maki Hirate, 2003, Journal of neuroscience research.

Activation of the serum-response and TPA-response elements by expression of the v-abl protein: comparison of the mode of action of the v-abl protein with those of protein kinase C, cyclic AMP-dependent protein kinase, and the activated c-raf protein.

K. Kaibuchi, Y. Takai, N. Oku, 1990, Oncogene.

Activation of the c-fos serum-response element by the activated c-Ha-ras protein in a manner independent of protein kinase C and cAMP-dependent protein kinase.

K. Kaibuchi, Y. Takai, N. Oku, 1990, The Journal of biological chemistry.

65Zn localization in rat brain after intracerebroventricular injection of 65Zn-histidine

N. Oku, S. Okada, A. Takeda, 2000, Brain Research.

Antitumor activity of liposomal naphthoquinone esters isolated from Thai medicinal plant: Rhinacanthus nasutus KURZ.

N. Oku, T. Asai, K. Shimizu, 2006, Biological & pharmaceutical bulletin.

Role of Sialylglycoconjugate(s) in the Initial Phase of Metastasis of Liver‐metastatic RAW117 Lymphoma Cells

T. Irimura, H. Tsukada, D. Miyamoto, 1998, Japanese journal of cancer research : Gann.

Targeting and anti-tumor efficacy of liposomal 5'-O-dipalmitoylphosphatidyl 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine in mice lung bearing B16BL6 melanoma.

S. Shuto, H. Ohba, H. Tsukada, 2001, Cancer letters.

Involvement of Tumor Lymphatic System in Translocation of Intratumorally Injected Liposomes.

N. Oku, K. Shimizu, Genki Nakamura, 2018, Biological & pharmaceutical bulletin.

Liposomal Applications to Cancer Therapy

N. Oku, Y. Namba, 1993 .

Nobiletin Reduces Intracellular and Extracellular β-Amyloid in iPS Cell-Derived Alzheimer's Disease Model Neurons.

J. Kimura, Y. Ohizumi, N. Oku, 2018, Biological & pharmaceutical bulletin.

Studies on the interaction of HVJ (Sendai Virus) with liposomal membranes. HVJ-induced permeability increase of liposomes containing glycophorin.

N. Oku, S. Nojima, K. Inoue, 1982, Virology.

Studies on the interaction of Sendai virus with liposomal membranes. Sendai virus-induced agglutination of liposomes containing glycophorin.

N. Oku, S. Nojima, K. Inoue, 1981, Biochimica et biophysica acta.

Release rate is a key variable affecting the therapeutic effectiveness of liposomal fasudil for the treatment of cerebral ischemia/reperfusion injury.

N. Oku, T. Asai, T. Fukuta, 2020, Biochemical and biophysical research communications.

Deuterium-Resistant Algal Cell Line for D Labeling of Heterotrophs Expresses Enhanced Level of Hsp60 in D2O Medium

N. Oku, S. Okada, K. Unno, 2005, Applied and Environmental Microbiology.

Cell-nuclear accumulation of 72-kDa stress protein induced by dimethylated arsenics.

N. Oku, S. Okada, K. Yamanaka, 1997, Biological & pharmaceutical bulletin.

A simple procedure for the determination of the trapped volume of liposomes

R. Macdonald, N. Oku, D. Kendall, 1982 .

Anticancer Efficacy of the Combination of Berberine and PEGylated Liposomal Doxorubicin in Meth A Sarcoma-Bearing Mice.

N. Oku, T. Asai, P. Siripong, 2018, Biological & pharmaceutical bulletin.

Identification of oligopeptides binding to peritoneal tumors of gastric cancer

D. Kerr, N. Oku, T. Asai, 2006, Cancer science.

Accumulation of macromolecules in brain parenchyma in acute phase of cerebral infarction/reperfusion

N. Oku, T. Asai, T. Urakami, 2010, Brain Research.

Isolation of a novel peptide homing to tumor-derived neovasculature that suppresses tumor growth.

N. Oku, T. Asai, K. Ogino, 2002, Biological & pharmaceutical bulletin.

Amelioration of cerebral ischemia-reperfusion injury based on liposomal drug delivery system with asialo-erythropoietin.

N. Oku, T. Asai, K. Shimizu, 2012, Journal of controlled release : official journal of the Controlled Release Society.

Comparison of the mode of action of ras p21 with those of protein kinases A and C in the stimulation of gene expression in NIH/3T3 cells

K. Kaibuchi, Y. Takai, N. Oku, 1990, FEBS letters.

Functional role of sialyl Lewis X and fibronectin‐derived RGDS peptide analogue on tumor‐cell arrest in lungs followed by extravasation

H. Tsukada, I. Saiki, J. Murata, 1996, International journal of cancer.

Increased expression of Hsp70 for resistance to deuterium oxide in a yeast mutant cell line.

M. Morioka, N. Oku, S. Okada, 2003, Biological & pharmaceutical bulletin.

Neuroprotective effect of nobiletin on cerebral ischemia–reperfusion injury in transient middle cerebral artery-occluded rats

S. Yamada, Y. Ohizumi, N. Oku, 2014, Brain Research.

Development of a Simple Cell Invasion Assay System.

N. Oku, S. Yamakawa, Y. Furuyama, 2000, Biological & pharmaceutical bulletin.

New strategy for MS treatment with autoantigen-modified liposomes and their therapeutic effect.

Y. Magata, N. Oku, T. Asai, 2021, Journal of controlled release : official journal of the Controlled Release Society.

Increase in hippocampal cell death after treatment with kainate in zinc deficiency

N. Oku, A. Takeda, Kohei Yamada, 2005, Neurochemistry International.

High K+-induced Increase in Extracellular Glutamate in Zinc Deficiency and Endogenous Zinc Action

N. Oku, A. Takeda, Hiromasa Itoh, 2009 .

Response of hippocampal mossy fiber zinc to excessive glutamate release

N. Oku, A. Takeda, A. Minami, 2007, Neurochemistry International.

Release of amino acids by zinc in the hippocampus

Yumiko Seki, N. Oku, A. Takeda, 2004, Brain Research Bulletin.

Inhibitory function of zinc against excitation of hippocampal glutamatergic neurons

Yumiko Seki, N. Oku, A. Takeda, 2003, Epilepsy Research.

Susceptibility to kainate‐induced seizures under dietary zinc deficiency

N. Oku, A. Takeda, Maki Hirate, 2003, Journal of neurochemistry.

Zinc movement in the brain under kainate-induced seizures

N. Oku, A. Takeda, Maki Hirate, 2003, Epilepsy Research.

Alteration of zinc concentrations in the brain implanted with C6 glioma

N. Oku, A. Takeda, H. Tamano, 2003, Brain Research.

Distribution of trace elements in the brain of EL (epilepsy) mice

N. Oku, A. Takeda, S. Enomoto, 2002, Epilepsy Research.

Relationship between zinc and neurotransmitters released into the amygdalar extracellular space

N. Oku, A. Takeda, A. Minami, 2002, Brain Research.

Cadmium toxicity in synaptic neurotransmission in the brain

N. Oku, A. Takeda, A. Minami, 2001, Brain Research.

Release of zinc from the brain of El (epilepsy) mice during seizure induction

N. Oku, S. Okada, A. Ishige, 1999, Brain Research.

Formulation Design and Evaluation of Liposomal Sepantronium Bromide (YM155), a Small-Molecule Survivin Suppressant, Based on Pharmacokinetic Modeling and Simulation

N. Oku, K. Sako, A. Maeda, 2014, Pharmaceutical Research.

Lipid Nanoparticle-mediated Delivery of Small Interfering RNA for Cancer Therapy

N. Oku, T. Asai, Takehisa Dewa, 2016 .

Polycation liposomes as a vector for potential intracellular delivery of microRNA

N. Oku, Ayaka Okamoto, T. Asai, 2013, The journal of gene medicine.

GD1α‐replica peptides functionally mimic GD1α, an adhesion molecule of metastatic tumor cells, and suppress the tumor metastasis

Y. Hirabayashi, N. Oku, K. Ogino, 1998 .

Electron microscopic study on the interaction of Sendai virus with liposomes containing glycophorin.

Y. Nozawa, N. Oku, S. Nojima, 1982, Biochimica et Biophysica Acta.

In vivo trafficking of endothelial progenitor cells their possible involvement in the tumor neovascularization.

H. Tsukada, M. Nakajima, N. Oku, 2004, Life sciences.

Potential usage of thermosensitive liposomes for macromolecule delivery.

N. Oku, S. Okada, R. Naruse, 1994, Biochimica et biophysica acta.

Development of a liposomal drug delivery system for the treatment of ischemic stroke

N. Oku, T. Asai, T. Fukuta, 2015 .

Upregulatory Effects of Nobiletin, a Citrus Flavonoid with Anti-dementia Activity, on the Gene Expression of mAChR, ChAT, and CBP

J. Kimura, Y. Ohizumi, N. Oku, 2015 .

HYDROPHOBIC MODIFICATION OF POLY(MA-CDA) TO ENHANCE BIOLOGICAL ACTIVITY*

N. Oku, Y. Suda, R. Ottenbrite, 2002 .

Modified Polyanionic Polymers for Enhanced Cell Membrane Interaction

S. Kusumoto, N. Oku, Y. Suda, 1992 .

Solubilization of human placental tumor necrosis factor receptors as a complex with a guanine nucleotide-binding protein.

T. Hori, M. Tsujimoto, N. Oku, 1991, Archives of biochemistry and biophysics.

Development of tissue factor-targeted liposomes for effective drug delivery to stroma-rich tumors.

Y. Magata, N. Oku, K. Shimizu, 2020, Journal of controlled release : official journal of the Controlled Release Society.

Antineovascular therapy with angiogenic vessel‐targeted polyethyleneglycol‐shielded liposomal DPP–CNDAC

S. Shuto, N. Oku, T. Asai, 2008, Cancer science.

Enhanced desensitization efficacy by liposomal conjugation of a specific antigen.

N. Oku, T. Asai, T. Urakami, 2007, International journal of pharmaceutics.

PEI6, a new basic secretagogue in rat peritoneal mast cells: characteristics of polyethylenimine PEI6 resemble those of compound 48/80.

M. Nango, N. Oku, M. Uchida, 1995, General pharmacology.

1-O-Palmityl-D-glucuronate Endows Liposomes with Long Half-Life In Vivo

N. Oku, Y. Namba, M. Masada, 1989 .

Suppression of cerebral ischemia/reperfusion injury by efficient release of encapsulated ifenprodil from liposomes under weakly acidic pH conditions.

N. Oku, Hiroyuki Koide, T. Asai, 2019, Journal of pharmaceutical sciences.

Selective release of non-electrolytes from liposomes upon perturbation of bilayers by temperature change or polyene antibiotics.

N. Oku, S. Nojima, K. Inoue, 1980, Biochimica et biophysica acta.

Molecular genetic analysis of the regulatory and catalytic domains of protein kinase C.

K. Arai, M. Muramatsu, K. Kaibuchi, 1989, The Journal of biological chemistry.

Intensive tumor suppression by anti-angiogenic photodynamic therapy with polycation-modified liposomal photosensitizer.

M. Nango, N. Oku, Y. Takeuchi, 2002, Cellular & molecular biology letters.

Growth inhibition of human fibroblasts by epidermal growth factor in the presence of arachidonic acid.

T. Hori, N. Oku, S. Shibamoto, 1990, Biochemical and biophysical research communications.

Preferential uptake of zinc, manganese, and rubidium in rat brain tumor.

N. Oku, A. Takeda, S. Enomoto, 2002, Nuclear medicine and biology.

Zinc-65 imaging of rat brain tumors.

N. Oku, A. Takeda, S. Enomoto, 2001, Cancer research.

Junctional Adhesion Molecule-C Promotes Metastatic Potential of HT1080 Human Fibrosarcoma*

N. Oku, T. Asai, T. Hikita, 2007, Journal of Biological Chemistry.

Therapeutic effect of adriamycin encapsulated in long‐circulating liposomes on meth‐a‐sarcoma‐bearing mice

N. Oku, S. Okada, Y. Namba, 1994, International journal of cancer.

Literature Search on the Interaction Between Warfarin and Vitamin K

H. Noguchi, S. Onoue, S. Yamada, 2009 .

Design of a Novel PEGylated Liposomal Vector for Systemic Delivery of siRNA to Solid Tumors.

N. Oku, Ayaka Okamoto, Hiroyuki Koide, 2019, Biological & pharmaceutical bulletin.

Usefulness of positron emission tomographic visualization for examination of in vivo susceptibility to metastasis

H. Tsukada, N. Oku, H. Kikkawa, 2000, Cancer.

Possible role of immune surveillance at the initial phase of metastasis produced by B16BL6 melanoma cells

H. Tsukada, N. Oku, H. Kikkawa, 2000, FEBS letters.

How platelet aggregation affects B16BL6 melanoma cell trafficking

T. Irimura, H. Tsukada, N. Oku, 1998, FEBS letters.

Tyrosine phosphorylation of beta-catenin and plakoglobin enhanced by hepatocyte growth factor and epidermal growth factor in human carcinoma cells.

K. Miyazawa, M. Takeichi, K. Takeuchi, 1994, Cell adhesion and communication.

Stimulation of prostaglandin production by hepatocyte growth factor in human gastric carcinoma cells

K. Miyazawa, K. Takeuchi, T. Hori, 1993, FEBS letters.

Possible role of prostaglandins as negative regulators in growth stimulation by tumor necrosis factor and epidermal growth factor in human fibroblasts

T. Hori, M. Tsujimoto, N. Oku, 1989, Journal of cellular physiology.

Suppressed permeation of linoleic acid in a liposomal formulation through reconstructed skin tissue.

N. Oku, N. Baba, S. Yonezawa, 2004, Biological & pharmaceutical bulletin.

Enhanced antitumor activity of xanthohumol, a diacylglycerol acyltransferase inhibitor, under hypoxia.

N. Oku, T. Asai, H. Tomoda, 2005, Cancer letters.

Synthetic hydrogel nanoparticles for sepsis therapy

Kazuhiro Saito, K. Goda, Y. Hoshino, 2021, Nature Communications.

A new and known cytotoxic aryltetralin-type lignans from stems of Bursera graveolens.

M. Iinuma, N. Oku, M. A. P. Farrera, 2005, Chemical & pharmaceutical bulletin.

Synthesis of Chemical-Biology Tools Enabling in vivo Imaging and Analysis of Epigallocatechin Gallate

K. Itoh, N. Oku, K. Shimizu, 2016 .

Inhibitory effect of liposomal rhinacanthin-N isolated from Rhinacanthus nasutus on pulmonary metastasis in mice.

N. Oku, Hiroyuki Koide, K. Shimizu, 2012, Biological & pharmaceutical bulletin.

Induction of apoptosis by rhinacanthone isolated from Rhinacanthus nasutus roots in human cervical carcinoma cells.

N. Oku, S. Ruchirawat, K. Kanokmedhakul, 2009, Biological & pharmaceutical bulletin.

Antiproliferative naphthoquinone esters from Rhinacanthus nasutus Kurz. roots on various cancer cells

N. Oku, S. Ruchirawat, P. Siripong, 2006 .

Induction of apoptosis in tumor cells by three naphthoquinone esters isolated from Thai medicinal plant: Rhinacanthus nasutus KURZ.

N. Oku, T. Asai, K. Shimizu, 2006, Biological & pharmaceutical bulletin.

Involvement of glucocorticoid-mediated Zn2+ signaling in attenuation of hippocampal CA1 LTP by acute stress

Miki Suzuki, N. Oku, A. Takeda, 2012, Neurochemistry International.

Involvement of N‐methyl‐D‐aspartate receptor subunits in zinc‐mediated modification of CA1 long‐term potentiation in the developing hippocampus

N. Oku, A. Takeda, K. Itagaki, 2012, Journal of neuroscience research.

Unique Induction of CA1 LTP Components After Intake of Theanine, an Amino Acid in Tea Leaves and its Effect on Stress Response

Miki Suzuki, Kazuhiro Sakamoto, N. Oku, 2011, Cellular and Molecular Neurobiology.

Differential effects of zinc influx via AMPA/kainate receptor activation on subsequent induction of hippocampal CA1 LTP components

Miki Suzuki, N. Oku, A. Takeda, 2010, Brain Research.

Zinc differentially acts on components of long-term potentiation at hippocampal CA1 synapses

Miki Suzuki, N. Oku, A. Takeda, 2010, Brain Research.

The rational design of a synthetic polymer nanoparticle that neutralizes a toxic peptide in vivo

Hiroyuki Koide, Yu Hoshino, Shih-Hui Lee, 2011, Proceedings of the National Academy of Sciences.

Metabolic methylation is a possible genotoxicity-enhancing process of inorganic arsenics.

N. Oku, S. Okada, K. Yamanaka, 1997, Mutation research.

In vivo recognition of cyclopentadienyltricarbonylrhenium (CpTR) derivatives.

N. Oku, T. Uehara, Y. Arano, 2003, Nuclear medicine and biology.

Transmembrane electron transfer as catalyzed by poly(ethylenimine)-linked manganese porphyrins.

M. Nango, N. Oku, T. Dannhauser, 1986, Journal of the American Chemical Society.

Design of abiotic polymer ligand-decorated lipid nanoparticles for effective neutralization of target toxins in the blood.

Y. Hoshino, N. Oku, Hiroyuki Koide, 2021, Biomaterials science.

Enhancement of target toxin neutralization effect in vivo by PEGylation of multifunctionalized lipid nanoparticles.

N. Oku, Hiroyuki Koide, H. Egami, 2021, Biochemical and biophysical research communications.

Design of synthetic polymer nanoparticles that capture and neutralize a toxic peptide.

Hiroyuki Koide, Yoshio Okahata, Yu Hoshino, 2009, Small.

Skin whitening effect of linoleic acid is enhanced by liposomal formulations.

N. Oku, N. Baba, H. Ando, 2004, Biological & pharmaceutical bulletin.

Liposomal Formulation for Oral Delivery of Cyclosporine A: Usefulness as a Semisolid-Dispersion System

M. Kataoka, S. Yamashita, N. Oku, 2022, Pharmaceutical Research.

Unique response of zinc in the hippocampus to behavioral stress and attenuation of subsequent mossy fiber long-term potentiation.

N. Oku, A. Takeda, M. Ando, 2009, Neurotoxicology.

Evaluating tamsulosin hydrochloride-released microparticles prepared using single-step matrix coating.

T. Shinoda, N. Oku, A. Maeda, 2011, International journal of pharmaceutics.

Effect of freeze-thawing on phospholipid/surfactant mixed bilayers.

N. Oku, S. Okada, K. Kurohane, 1996, Chemical and pharmaceutical bulletin.

Beta-thujaplicin zinc chelate induces apoptosis in mouse high metastatic melanoma B16BL6 cells.

D. Miyamoto, N. Oku, Y. Suzuki, 1998, Biological & pharmaceutical bulletin.

Liposomal Arg-Gly-Asp analogs effectively inhibit metastatic B16 melanoma colonization in murine lungs.

I. Saiki, N. Oku, Y. Tokudome, 1996, Life sciences.

Enhancement of antitumor activity of OK-432 (picibanil) by Triton X-114 phase partitioning.

M. Hashimoto, S. Kusumoto, N. Oku, 2008, International immunopharmacology.

Non-invasive evaluation of neuroprotective drug candidates for cerebral infarction by PET imaging of mitochondrial complex-I activity

N. Harada, H. Tsukada, N. Oku, 2016, Scientific Reports.

Preventive effect of green tea catechins on experimental tumor metastasis in senescence-accelerated mice.

Kosuke Shimizu, Keiko Unno, Tomohiro Asai, 2010, Biological & pharmaceutical bulletin.

Tumor necrosis factor is cytotoxic to human fibroblasts in the presence of exogenous arachidonic acid.

T. Hori, M. Tsujimoto, N. Oku, 1989, Experimental cell research.

Application of liposomes for cancer metastasis

H. Tsukada, I. Saiki, J. Murata, 1997 .

Evaluation of O-[(18)F]fluoromethyl-D-tyrosine as a radiotracer for tumor imaging with positron emission tomography.

H. Tsukada, D. Fukumoto, N. Oku, 2009, Nuclear medicine and biology.

Antitumor efficacy and biodistribution of liposomal sepantronium bromide (YM155), a novel small-molecule survivin suppressant.

N. Oku, K. Sako, A. Maeda, 2014, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Speaker Abstracts

K. White, D. Ward, P. Sax, 2017, Journal of the International AIDS Society.

A New Bioassay of Environmental Chemicals Based on Their Effects on Tumor Cell Invasion

Y. Ueda, N. Oku, M. Kunimoto, 2002 .

Anti‐neovascular therapy by liposomal DPP‐CNDAC targeted to angiogenic vessels

S. Shuto, A. Matsuda, N. Oku, 2002, FEBS letters.

Systemic delivery of small RNA using lipid nanoparticles.

N. Oku, T. Asai, 2014, Biological & pharmaceutical bulletin.

Release mechanisms of tacrolimus-loaded PLGA and PLA microspheres and immunosuppressive effects of the microspheres in a rat heart transplantation model.

N. Oku, M. Maeda, R. Kojima, 2015, International journal of pharmaceutics.

Relationship between brain zinc and transient learning impairment of adult rats fed zinc-deficient diet

N. Oku, S. Okada, A. Takeda, 2000, Brain Research.

Argonaute2 is a potential target for siRNA-based cancer therapy for HT1080 human fibrosarcoma

N. Yamazaki, N. Oku, T. Asai, 2011, Drug Delivery and Translational Research.

Disappearance of the angiogenic potential of endothelial cells caused by Argonaute2 knockdown.

Tomohiro Asai, Naoto Oku, J. Yokota, 2008, Biochemical and biophysical research communications.

Antibody-modified lipid nanoparticles for selective delivery of siRNA to tumors expressing membrane-anchored form of HB-EGF.

E. Mekada, N. Oku, Ayaka Okamoto, 2014, Biochemical and biophysical research communications.

Possible involvement of plasma histidine in differential brain permeability to zinc and cadmium

N. Oku, A. Takeda, Mai Suzuki, 2002, Biometals.

Inhibition of Akt (ser473) phosphorylation and rapamycin-resistant cell growth by knockdown of mammalian target of rapamycin with small interfering RNA in vascular endothelial growth factor receptor-1-targeting vector.

M. Nango, N. Oku, Hiroyuki Koide, 2011, Biological & pharmaceutical bulletin.

Charge-reversible Lipid Derivative: A Novel Type of pH-responsive Lipid for Nanoparticle-mediated siRNA Delivery.

N. Oku, Hiroyuki Koide, Yusuke Hirai, 2020, International journal of pharmaceutics.

One-step encapsulation of siRNA between lipid-layers of multi-layer polycation liposomes by lipoplex freeze-thawing.

N. Oku, Ayaka Okamoto, Hiroyuki Koide, 2016, Journal of controlled release : official journal of the Controlled Release Society.

Liposomes and nanotechnology in drug development: focus on ocular targets

Yoshihiko Araki, Tomohiro Asai, Naoto Oku, 2012, International journal of nanomedicine.

Potential usage of liposomal 4beta-aminoalkyl-4'-O-demethyl-4-desoxypodophyllotoxin (TOP-53) for cancer chemotherapy.

Kosuke Shimizu, Miki Takada, Tomohiro Asai, 2002, Biological & pharmaceutical bulletin.

Polycation liposome-mediated gene transfer in vivo.

M. Nango, N. Oku, M. Sugiyama, 2003, Biochimica et biophysica acta.

Identification of melanoma‐specific serological markers using proteomic analyses

T. Ashizawa, K. Yamaguchi, Y. Akiyama, 2009 .

Key determinants of siRNA delivery mediated by unique pH-responsive lipid-based liposomes.

N. Oku, Ayaka Okamoto, Hiroyuki Koide, 2019, International journal of pharmaceutics.

Facilitation of zinc influx via AMPA/kainate receptor activation in the hippocampus

N. Oku, A. Takeda, M. Ando, 2009, Neurochemistry International.

Behavior in the forced swim test and neurochemical changes in the hippocampus in young rats after 2-week zinc deprivation

N. Oku, A. Takeda, H. Tamano, 2009, Neurochemistry International.

Prediction of the Oral Pharmacokinetics and Food Effects of Gabapentin Enacarbil Extended-Release Tablets Using Biorelevant Dissolution Tests.

N. Oku, T. Asai, A. Kambayashi, 2018, Biological & pharmaceutical bulletin.

Dynamic analysis of fluid distribution in the gastrointestinal tract in rats: positron emission tomography imaging after oral administration of nonabsorbable marker, [(18)F]Deoxyfluoropoly(ethylene glycol).

Yasuyoshi Watanabe, Y. Sugiyama, Masaaki Suzuki, 2013, Molecular pharmaceutics.

Drug Carrier Systems for Anticancer Agents

N. Oku, Hiroyuki Koide, T. Asai, 2019 .

Targeted delivery of anticancer drugs to tumor vessels by use of liposomes modified with a peptide identified by phage biopanning with human endothelial progenitor cells.

N. Oku, T. Asai, H. Kikuchi, 2017, International journal of pharmaceutics.

Anticancer Agents: Drug Carrier Systems

N. Oku, Hiroyuki Koide, T. Asai, 2015 .

Cancer anti-angiogenic therapy.

N. Oku, K. Shimizu, 2004, Biological & pharmaceutical bulletin.

Application of polyethyleneglycol (PEG)-modified liposomes for oral vaccine: effect of lipid dose on systemic and mucosal immunity.

S. Yamashita, N. Oku, M. Kakemi, 2003, Journal of controlled release : official journal of the Controlled Release Society.

Suppression of immune response by antigen-modified liposomes encapsulating model agents: a novel strategy for the treatment of allergy.

N. Oku, T. Asai, T. Ishida, 2013, Journal of controlled release : official journal of the Controlled Release Society.

In vitro efficacy of a sterically stabilized immunoliposomes targeted to membrane type 1 matrix metalloproteinase (MT1-MMP).

Hideo Kobayashi, Takanori Aoki, Hiroshi Kikuchi, 2007, Biological & pharmaceutical bulletin.

DNA single-strand breaks in L-132 cells resulting from inhibition of repair polymerization shortly after exposure to dimethylarsinic acid.

N. Oku, S. Okada, K. Yamanaka, 1997, Biological & pharmaceutical bulletin.

Dimethylarsenics reveal DNA damage induced by superoxide anion radicals.

N. Oku, S. Okada, K. Kawaguchi, 1996, Biological & pharmaceutical bulletin.

Design of Synthetic Polymer Nanoparticles Specifically Capturing Indole, a Small Toxic Molecule.

Y. Hoshino, N. Oku, Hiroyuki Koide, 2019, Biomacromolecules.

Chronopharmacologic cancer treatment with an angiogenic vessel-targeted liposomal drug.

N. Oku, T. Asai, K. Shimizu, 2008, Biological & pharmaceutical bulletin.

Tumor cells with organ-specific metastatic ability show distinctive trafficking in vivo: analyses by positron emission tomography and bioimaging.

T. Irimura, H. Tsukada, N. Oku, 1997, Cancer research.

Proteomic characterization of angiogenic endothelial cells stimulated with cancer cell-conditioned medium.

N. Oku, T. Asai, N. Ohashi, 2007, Biological & pharmaceutical bulletin.

Role of integrin alpha(v)beta3 in the early phase of liver metastasis: PET and IVM analyses.

T. Kakiuchi, H. Tsukada, Y. Takada, 2002, Clinical & experimental metastasis.

Evaluation of drug targeting strategies and liposomal trafficking.

H. Tsukada, N. Oku, T. Asai, 2000, Current pharmaceutical design.

Antineovascular therapy, a novel antiangiogenic approach

N. Oku, T. Asai, K. Shimizu, 2005, Expert opinion on therapeutic targets.

Enhanced Efficacy of Doxorubicin by microRNA-499-Mediated Improvement of Tumor Blood Flow

N. Oku, Ayaka Okamoto, T. Asai, 2016, Journal of Clinical Medicine.

Significance of serum glucocorticoid and chelatable zinc in depression and cognition in zinc deficiency

N. Oku, A. Takeda, H. Tamano, 2012, Behavioural Brain Research.

Suppressive effect of Yokukansan on excessive release of glutamate and aspartate in the hippocampus of zinc-deficient rats

N. Oku, M. Yuzurihara, A. Takeda, 2008, Nutritional neuroscience.

A polymer nanoparticle with engineered affinity for a vascular endothelial growth factor (VEGF165).

Y. Miura, Y. Hoshino, N. Oku, 2017, Nature chemistry.

Attenuation of abnormal glutamate release in zinc deficiency by zinc and Yokukansan

N. Oku, A. Takeda, Hiromasa Itoh, 2008, Neurochemistry International.

Cancer antineovascular therapy with liposome drug delivery systems targeted to BiP/GRP78

N. Oku, T. Asai, N. Ohashi, 2010, International journal of cancer.

Tumor Imaging with Long Circulating Liposomes

N. Oku, 1998 .

Amelioration of Citrobacter rodentium proliferation in early stage of infection in mice by pretreatment with Lactobacillus brevis KB290 and verification using in vivo bioluminescence imaging

N. Oku, Hiroyuki Koide, N. Ohashi, 2016, FEMS microbiology letters.

Anti‐neovascular therapy by liposomal drug targeted to membrane type‐1 matrix metalloproteinase

H. Tsukada, N. Oku, T. Asai, 2004, International journal of cancer.

Long-circulating liposomes.

N. Oku, Y. Namba, N Oku, 1994, Critical reviews in therapeutic drug carrier systems.

Applications of Liposomal Drug Delivery Systems to Develop Neuroprotective Agents for the Treatment of Ischemic Stroke.

N. Oku, T. Asai, T. Fukuta, 2019, Biological & pharmaceutical bulletin.

Treatment of PTEN-null breast cancer by a synthetic lethal approach involving PARP1 gene silencing.

N. Oku, Ayaka Okamoto, Hiroyuki Koide, 2023, Journal of pharmaceutical sciences.

Enhancement of social isolation-induced aggressive behavior of young mice by zinc deficiency.

N. Oku, A. Takeda, Kohei Yamada, 2008, Life sciences.

Anxiety-like behavior of young rats after 2-week zinc deprivation

Hiromasa Itoh, Atsushi Takeda, Naoto Oku, 2007, Behavioural Brain Research.

Abnormal Ca2+ mobilization in hippocampal slices of epileptic animals fed a zinc-deficient diet

N. Oku, A. Takeda, Hiromasa Itoh, 2009, Epilepsy Research.

Oral delivery of insulin by using surface coating liposomes improvement of stability of insulin in GI tract

S. Yamashita, M. Nango, N. Oku, 1997 .

Application of surface-coated liposomes for oral delivery of peptide: effects of coating the liposome's surface on the GI transit of insulin.

S. Yamashita, N. Oku, Y. Namba, 1999, Journal of pharmaceutical sciences.

Development of double-stranded siRNA labeling method using positron emitter and its in vivo trafficking analyzed by positron emission tomography.

N. Harada, H. Tsukada, N. Oku, 2010, Bioconjugate chemistry.

109Cd transport in rat brain

N. Oku, S. Okada, A. Takeda, 1999, Brain Research Bulletin.

RGD-based active targeting of novel polycation liposomes bearing siRNA for cancer treatment.

Kosuke Shimizu, Tomohiro Asai, Naoto Oku, 2012, Journal of controlled release : official journal of the Controlled Release Society.

Differential effects of zinc on glutamatergic and GABAergic neurotransmitter systems in the hippocampus

Yumiko Seki, N. Oku, A. Takeda, 2004, Journal of neuroscience research.

Solubilization of phospholipids by chaotropic ion solutions.

R. Macdonald, N. Oku, 1983, The Journal of biological chemistry.

Polyamine – Lipid Conjugates as Effective Gene Carriers: Chemical Structure, Morphology, and Gene Transfer Activity

M. Nango, N. Oku, T. Asai, 2011 .

Manganese influences the levels of neurotransmitters in synapses in rat brain

N. Sotogaku, N. Oku, A. Takeda, 2002, Neuroscience.

Intracellular target for photosensitization in cancer antiangiogenic photodynamic therapy mediated by polycation liposome.

M. Nango, N. Oku, Y. Takeuchi, 2004, Journal of controlled release : official journal of the Controlled Release Society.

Polycation liposome enhances the endocytic uptake of photosensitizer into cells in the presence of serum.

M. Nango, N. Oku, Y. Takeuchi, 2003, Bioconjugate chemistry.

PET imaging of brain cancer with positron emitter-labeled liposomes.

H. Tsukada, N. Oku, T. Asai, 2011, International journal of pharmaceutics.

Bauhinia purprea agglutinin‐modified liposomes for human prostate cancer treatment

N. Oku, K. Shimizu, M. Shimizu, 2015, Cancer science.

Development of anti-HB-EGF immunoliposomes for the treatment of breast cancer.

E. Mekada, S. Takashima, N. Oku, 2012, Journal of controlled release : official journal of the Controlled Release Society.

Innovations in Liposomal DDS Technology and Its Application for the Treatment of Various Diseases.

N. Oku, 2017, Biological & pharmaceutical bulletin.

Increases in extracellular zinc in the amygdala in acquisition and recall of fear experience and their roles in response to fear

N. Oku, A. Takeda, S. Imano, 2010, Neuroscience.

Susceptibility of PTEN-positive metastatic tumors to small interfering RNA targeting the mammalian target of rapamycin.

M. Nango, N. Oku, Hiroyuki Koide, 2015, Nanomedicine : nanotechnology, biology, and medicine.

[Activation of retinoic acid (RA)-differentiated HL-60 cells by saponins].

N. Oku, S. Okada, Y. Sagesaka, 1995, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

Advanced cancer therapy by integrative antitumor actions via systemic administration of miR-499.

N. Oku, Ayaka Okamoto, Hiroyuki Koide, 2014, Journal of controlled release : official journal of the Controlled Release Society.

T cell-independent B cell response is responsible for ABC phenomenon induced by repeated injection of PEGylated liposomes.

H. Tsukada, N. Oku, Hiroyuki Koide, 2010, International journal of pharmaceutics.

The phototoxicity of photofrin was enhanced by PEGylated liposome in vitro.

Toru Hirano, Naoto Oku, Hiroyuki Konno, 2006, Cancer letters.

Dorsal Air Sac Model

N. Oku, T. Asai, S. Yonezawa, 2007 .

Transient Increase in Zn2+ in Hippocampal CA1 Pyramidal Neurons Causes Reversible Memory Deficit

Miki Suzuki, N. Oku, A. Takeda, 2011, PloS one.

Positron emission tomography analysis of metastatic tumor cell trafficking.

T Irimura, T. Irimura, H. Tsukada, 1994, Cancer research.

Impairment of recognition memory and hippocampal long-term potentiation after acute exposure to clioquinol

N. Oku, A. Takeda, H. Tamano, 2010, Neuroscience.

Distinct effects of Na+ and Li+ on the induction of morphological changes in A431 cells mediated by epidermal growth factor.

N. Oku, S. Shibamoto, F. Ito, 1987, Cell structure and function.

Treatment of stroke with liposomal neuroprotective agents under cerebral ischemia conditions.

N. Oku, T. Asai, K. Shimizu, 2015, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Nanoparticles accumulate in ischemic core and penumbra region even when cerebral perfusion is reduced.

N. Oku, T. Asai, K. Shimizu, 2013, Biochemical and biophysical research communications.

Synthesis of angiogenesis-targeted peptide and hydrophobized polyethylene glycol conjugate.

N. Oku, Y. Takeuchi, Y. Namba, 2004, Bioorganic & medicinal chemistry letters.

Tumor imaging with technetium-99m-DTPA encapsulated in RES-avoiding liposomes.

N. Oku, S. Okada, Y. Namba, 1993, Nuclear medicine and biology.

GD1alpha-replica peptides functionally mimic GD1alpha, an adhesion molecule of metastatic tumor cells, and suppress the tumor metastasis.

Y. Hirabayashi, N. Oku, K. Ogino, 1998, FEBS letters.

Molecular Assembly of Zinc–Nickel Hybrid Porphyrin Dimer Using Synthetic 4α-Helix Polypeptides

T. Nagamura, M. Nango, N. Oku, 2002 .

Unique Induction of CA1 LTP Components After Intake of Theanine, an Amino Acid in Tea Leaves and its Effect on Stress Response

Miki Suzuki, Kazuhiro Sakamoto, N. Oku, 2011, Cellular and Molecular Neurobiology.

Enhancement of hippocampal mossy fiber activity in zinc deficiency and its influence on behavior

N. Oku, A. Takeda, Kohei Yamada, 2008, BioMetals.

Role of zinc influx via AMPA/kainate receptor activation in metabotropic glutamate receptor‐mediated calcium release

N. Oku, A. Takeda, A. Minami, 2007, Journal of neuroscience research.

Zinc release in the lateral nucleus of the amygdala by stimulation of the entorhinal cortex

Hiromasa Itoh, Atsushi Takeda, Naoto Oku, 2006, Brain Research.

Chemoprevention of Tumor Metastasis by Liposomal β-Sitosterol Intake

N. Oku, Hiroyuki Koide, T. Asai, 2008 .

Applicability of anti-neovascular therapy to drug-resistant tumor: suppression of drug-resistant P388 tumor growth with neovessel-targeted liposomal adriamycin.

N. Oku, T. Asai, K. Shimizu, 2005, International journal of pharmaceutics.

Brain Tumor Diagnosis Using PET with Angiogenic Vessel-Targeting Liposomes

N. Oku, K. Shimizu, 2011 .

Positive modulation of long-term potentiation at hippocampal CA1 synapses by low micromolar concentrations of zinc

N. Oku, A. Takeda, M. Ando, 2009, Neuroscience.

Zinc homeostasis in the brain of adult rats fed zinc‐deficient diet

N. Oku, A. Takeda, A. Minami, 2001, Journal of neuroscience research.

Inhibition of presynaptic activity by zinc released from mossy fiber terminals during tetanic stimulation

K. Kikuchi, T. Nagano, N. Oku, 2006, Journal of neuroscience research.

Effective tumor regression by anti-neovascular therapy in hypovascular orthotopic pancreatic tumor model.

N. Oku, T. Asai, S. Yonezawa, 2007, Journal of controlled release : official journal of the Controlled Release Society.

Dicetyl phosphate-tetraethylenepentamine-based liposomes for systemic siRNA delivery.

M. Nango, N. Oku, Hiroyuki Koide, 2011, Bioconjugate chemistry.

Upregulation of N-methyl-D-aspartate receptor subunits and c-Fos expressing genes in PC12D cells by nobiletin.

J. Kimura, Y. Ohizumi, N. Oku, 2014, Biological & pharmaceutical bulletin.

Liposomal polyamine-dialkyl phosphate conjugates as effective gene carriers: chemical structure, morphology, and gene transfer activity.

M. Nango, N. Oku, T. Asai, 2010, Bioconjugate chemistry.

Systemic Administration of siRNA with Anti-HB-EGF Antibody-Modified Lipid Nanoparticles for the Treatment of Triple-Negative Breast Cancer.

N. Oku, Ayaka Okamoto, Hiroyuki Koide, 2018, Molecular pharmaceutics.

Systemic delivery of small interfering RNA by use of targeted polycation liposomes for cancer therapy.

H. Tsukada, M. Nango, N. Oku, 2013, Biological & pharmaceutical bulletin.

Antiangiogenic photodynamic therapy (PDT) using Visudyne causes effective suppression of tumor growth.

N. Oku, Y. Takeuchi, Y. Namba, 2004, Cancer letters.

Liposomes modified with a synthetic Arg-Gly-Asp mimetic inhibit lung metastasis of B16BL6 melanoma cells.

N. Oku, Y. Namba, K. Kurohane, 2000, Life sciences.

A single injection of liposomal asialo-erythropoietin improves motor function deficit caused by cerebral ischemia/reperfusion.

N. Oku, T. Asai, K. Shimizu, 2012, International journal of pharmaceutics.

Cooling-induced, localized release of cytotoxic peptides from engineered polymer nanoparticles in living mice for cancer therapy.

Y. Hoshino, N. Oku, Hiroyuki Koide, 2023, Journal of controlled release : official journal of the Controlled Release Society.

Antitumor activity of vincristine encapsulated in glucuronide-modified long-circulating liposomes in mice bearing Meth A sarcoma.

N. Oku, Y. Tokudome, S. Okada, 1996, Biochimica et biophysica acta.

Preparation of giant liposomes.

R. Macdonald, N. Oku, N Oku, 1982, Biochimica et biophysica acta.

Site-specific protein synthesis in liver regeneration determined by PET.

H. Tsukada, N. Oku, S. Okada, 1995, Journal of Nuclear Medicine.

Nobiletin Reduces Intracellular and Extracellular β-Amyloid in iPS Cell-Derived Alzheimer's Disease Model Neurons.

J. Kimura, Y. Ohizumi, N. Oku, 2018, Biological & pharmaceutical bulletin.

Hippocampal calcium dyshomeostasis and long-term potentiation in 2-week zinc deficiency

N. Oku, A. Takeda, Kohei Yamada, 2008, Neurochemistry International.

Response of extracelluar zinc in the ventral hippocampus against novelty stress

N. Oku, A. Takeda, A. Minami, 2006, Journal of neurochemistry.

Suppression in mice of immunosurveillance against PEGylated liposomes by encapsulated doxorubicin.

N. Oku, T. Asai, H. Kikuchi, 2014, Journal of controlled release : official journal of the Controlled Release Society.

Development of anti-HB-EGF immunoliposomes for the treatment of breast cancer.

E. Mekada, S. Takashima, N. Oku, 2012, Journal of controlled release : official journal of the Controlled Release Society.

Suppressive effect of Yokukansan on excessive release of glutamate and aspartate in the hippocampus of zinc-deficient rats

N. Oku, M. Yuzurihara, A. Takeda, 2008, Nutritional neuroscience.

Suppression of choroidal neovascularization by intravitreal injection of liposomal SU5416.

N. Oku, T. Asai, Y. Araki, 2011, Archives of ophthalmology.

Zinc-mediated attenuation of hippocampal mossy fiber long-term potentiation induced by forskolin

N. Oku, A. Takeda, M. Ando, 2010, Neurochemistry International.

Metastasis of Breast Cancer Promoted by Circadian Rhythm Disruption due to Light/Dark Shift and its Prevention by Dietary Quercetin in Mice

N. Miura, N. Oku, T. Asai, 2021, Journal of circadian rhythms.

PET imaging of nobiletin based on a practical total synthesis.

N. Harada, H. Tsukada, N. Oku, 2011, Chemical communications.

Evaluation of O-[(18)F]fluoromethyl-D-tyrosine as a radiotracer for tumor imaging with positron emission tomography.

H. Tsukada, D. Fukumoto, N. Oku, 2009, Nuclear medicine and biology.

Prolonged targeting of ischemic/reperfused myocardium by liposomal adenosine augments cardioprotection in rats.

M. Sugimachi, N. Mochizuki, H. Asanuma, 2009, Journal of the American College of Cardiology.

PET imaging of brain cancer with positron emitter-labeled liposomes.

H. Tsukada, N. Oku, T. Asai, 2011, International journal of pharmaceutics.

Enhanced excitability of hippocampal mossy fibers and CA3 neurons under dietary zinc deficiency

T. Nagano, N. Oku, A. Takeda, 2005, Epilepsy Research.

Involvement of amygdalar extracellular zinc in rat behavior for passive avoidance

N. Oku, A. Takeda, A. Minami, 2004, Neuroscience Letters.

Ameliorating Effects of Sphingomyelin-Based Liposomes on Sarcopenia in Senescence-Accelerated Mice.

N. Oku, T. Asai, Yuuki Ishida, 2016, Biological & pharmaceutical bulletin.

Development of a miR‐92a delivery system for anti‐angiogenesis‐based cancer therapy

N. Oku, Ayaka Okamoto, T. Asai, 2013, The journal of gene medicine.

Modified Polyanionic Polymers. I: Grafting of Hydrophobic Group onto Poly(maleic acid-alt-3,4- dihydroxyphenylprop-1-ene) to Improve the Affinity for Cell Membranes

S. Yamashita, N. Oku, Y. Suda, 1992 .

Chaperonin-Repairable Subtle Incompleteness of Protein Assembly Induced by a Substitution of Hydrogen with Deuterium: Effect of GroE on Deuterated Ribulose 1,5-Bisphosphate Carboxylase

N. Oku, S. Okada, K. Unno, 1995 .

Negative modulation of presynaptic activity by zinc released from schaffer collaterals

N. Oku, A. Takeda, Sayuri Fuke, 2007, Journal of neuroscience research.

Zinc release from Schaffer collaterals and its significance

N. Oku, A. Takeda, A. Minami, 2006, Brain Research Bulletin.

Therapeutic effect of reticuloendothelial system (RES)-avoiding liposomes containing a phospholipid analogue of 5-fluorouracil, dipalmitoylphosphatidylfluorouridine, in Meth A sarcoma-bearing mice.

S. Shuto, N. Oku, S. Okada, 1994, Biological & pharmaceutical bulletin.

Ability of fibrinogen γ-derived dodecapeptides with different sequences to bind to rat platelets.

N. Watanabe, S. Takeoka, N. Oku, 2012, International journal of pharmaceutics.

Inhibitory effect of local anesthetics on Na+/H+ antiporter in brush border membrane-reconstituted vesicles.

T. Hori, M. Nango, N. Oku, 1990, Life sciences.

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