S. Sukharev

C. Kung, S. Sukharev, P. Blount, 1997, Gravitational and space biology bulletin : publication of the American Society for Gravitational and Space Biology.

Supplemental Information GsMTx 4 : Mechanism of Inhibiting Mechanosensitive Ion Channels

A. Ladokhin, F. Sachs, S. Sukharev, 2022 .

The membrane lateral pressure-perturbing capacity of parabens and their effects on the mechanosensitive channel directly correlate with hydrophobicity.

S. Sukharev, K. Kamaraju, 2008, Biochemistry.

Mechanosensitive channels: what can we learn from ‘simple’ model systems?

Sergei Sukharev, S. Sukharev, Andriy Anishkin, 2004, Trends in Neurosciences.

Properties of diphytanoyl phospholipids at the air-water interface.

S. Sukharev, Anthony Yasmann, 2015, Langmuir : the ACS journal of surfaces and colloids.

Searching for the molecular arrangement of transmembrane ceramide channels.

S. Sukharev, M. Colombini, M Colombini, 2006, Biophysical journal.

In vivo electroporation and stable transformation of skin cells of newborn mice by plasmid DNA.

S. Sukharev, A V Titomirov, S Sukharev, 1991, Biochimica et biophysica acta.

Electrically-Induced DNA Transfer into Cells. Electrotransfection in Vivo

S. Sukharev, V. A. Klenchin, A. V. Titomirov, 1994 .

Electrical properties of cell pellets and cell electrofusion in a centrifuge.

D. Zhelev, S. Sukharev, I. G. Abidor, 1993, Biochimica et biophysica acta.

The control of DNA replication in hybrids between neutrophils and fibroblasts

V. Prasolov, T. Pospelova, S. Sukharev, 1993, Cell proliferation.

Catalytic Role of the Substrate Defines Specificity of Therapeutic l-Asparaginase.

J. Weinstein, D. Rogers, Preeti Purwaha, 2015, Journal of molecular biology.

Glutaminase Activity of L-Asparaginase Contributes to Durable Preclinical Activity against Acute Lymphoblastic Leukemia

J. Weinstein, M. Konopleva, T. Link, 2019, Molecular Cancer Therapeutics.

High-Affinity Interactions of Beryllium(2+) with Phosphatidylserine Result in a Cross-Linking Effect Reducing Surface Recognition of the Lipid.

S. Sukharev, A. Dunina-Barkovskaya, Y. Ermakov, 2017, Biochemistry.

On the Conformation of the COOH-terminal Domain of the Large Mechanosensitive Channel MscL

H. Guy, S. Sukharev, A. Anishkin, 2003, The Journal of general physiology.

The mechanoelectrical response of the cytoplasmic membrane of Vibrio cholerae

A. Huq, S. Sukharev, I. Rowe, 2013, The Journal of general physiology.

Electroporation and electrophoretic DNA transfer into cells. The effect of DNA interaction with electropores.

L. Chernomordik, S. Sukharev, V. A. Klenchin, 1992, Biophysical journal.

The glutaminase activity of L-asparaginase is not required for anticancer activity against ASNS-negative cells.

J. Weinstein, D. Rogers, Preeti Purwaha, 2013, Blood.

Structural models of TREK channels and their gating mechanism

Carson C. Chow, H. Guy, A. Milac, 2011, Channels.

CHAPTER 29 – Microbial Channels

C. Kung, A. Kubalski, B. Martinac, 1994 .

Single residue substitutions that change the gating properties of a mechanosensitive channel in Escherichia coli.

C. Kung, S. Nagle, S. Sukharev, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Membrane topology and multimeric structure of a mechanosensitive channel protein of Escherichia coli.

H. Guy, C. Kung, S. Sukharev, 1996, The EMBO journal.

Mechanical Activation of MscL Revealed by a Locally Distributed Tension Molecular Dynamics Approach

S. Sukharev, J. Vanegas, A. Anishkin, 2020, bioRxiv.

Functional Reconstitution as an Assay for Biochemical Isolation of Channel Proteins: Application to the Molecular Identification of a Bacterial Mechanosensitive Channel

C. Kung, B. Martinac, S. Sukharev, 1994 .

Activation of bacterial channel MscL in mechanically stimulated droplet interface bilayers

D. Leo, J. Najem, M. Dunlap, 2015, Scientific Reports.

Mechanosensitive channels in microbes.

Boris Martinac, Sergei Sukharev, C. Kung, 2010, Annual review of microbiology.

Hydration properties of mechanosensitive channel pores define the energetics of gating

S. Sukharev, B. Akitake, K. Kamaraju, 2010, Journal of physics. Condensed matter : an Institute of Physics journal.

Structural models of the MscL gating mechanism.

H. Guy, S. Durell, S. Sukharev, 2001, Biophysical journal.

The gating mechanism of the large mechanosensitive channel MscL

H. Robert Guy, Sergei Sukharev, H. Guy, 2001, Nature.

MscL: a mechanosensitive channel in Escherichia coli.

H. Guy, C. Kung, B. Martinac, 1996, Society of General Physiologists series.

Capping transmembrane helices of MscL with aromatic residues changes channel response to membrane stretch.

S. Sukharev, C. Chiang, L. Shirinian, 2005, Biochemistry.

activity against ASNS-negative cells The glutaminase activity of l-asparaginase is not required for anticancer

J. Weinstein, D. Rogers, Preeti Purwaha, 2014 .

The mechanism of catalysis by L-asparaginase.

J. Weinstein, A. Wlodawer, D. Fushman, 2020, Biochemistry.

GsMTx4: Mechanism of Inhibiting Mechanosensitive Ion Channels.

A. Ladokhin, F. Sachs, S. Sukharev, 2017, Biophysical journal.

Membrane Affinity of Platensimycin and Its Dialkylamine Analogs

S. Sukharev, H. Sintim, I. Rowe, 2015, International journal of molecular sciences.

The mechanoelectrical response of droplet interface bilayer membranes.

D. Leo, J. Najem, M. Philen, 2016, Soft matter.

Gain-of-function Mutations Reveal Expanded Intermediate States and a Sequential Action of Two Gates in MscL

S. Sukharev, A. Anishkin, C. Chiang, 2005, The Journal of general physiology.

Mechanosensitive channels of Escherichia coli: the MscL gene, protein, and activities.

C Kung, C. Kung, B. Martinac, 1997, Annual review of physiology.

MscS inactivation and recovery are slow voltage-dependent processes sensitive to interactions with lipids

S. Sukharev, A. Anishkin, Joseph Maramba, 2023, bioRxiv.

A novel mechanosensitive channel controls osmoregulation, differentiation, and infectivity in Trypanosoma cruzi

S. Sukharev, A. Anishkin, N. Lander, 2021, eLife.

A bacterial-like mechanosensitive channel controls osmoregulation and infectivity in Trypanosoma cruzi

S. Sukharev, A. Anishkin, N. Lander, 2018, bioRxiv.

Tight hydrophobic core and flexible helices yield MscL with a high tension gating threshold and a membrane area mechanical strain buffer

Arjun Sharma, S. Sukharev, J. Vanegas, 2023, bioRxiv.

Mechanosensitive Channels: History, Diversity, and Mechanisms

S. Sukharev, A. Anishkin, S. Sukharev, 2022, Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology.

The voltage-dependence of MscL has dipolar and dielectric contributions and is governed by local intramembrane electric field

D. Leo, J. Najem, S. Sukharev, 2018, Scientific Reports.

Handbook of Ion Channels

S. Sukharev, A. Anishkin, 2023 .

Effects of Lys to Glu mutations in GsMTx4 on membrane binding, peptide orientation, and self-association propensity, as analyzed by molecular dynamics simulations.

F. Sachs, S. Sukharev, M. Nishizawa, 2015, Biochimica et biophysica acta.

Straightening and sequential buckling of the pore-lining helices define the gating cycle of MscS

Sergei Sukharev, Bradley Akitake, S. Sukharev, 2007, Nature Structural &Molecular Biology.

Towards an understanding of the structural and functional properties of MscL, a mechanosensitive channel in bacteria

C. Kung, S. Nagle, S. Sukharev, 1996, Biology of the cell.

Adaptive MscS gating in the osmotic permeability response in E. coli: the question of time.

S. Sukharev, A. Anishkin, Miriam Boer, 2011, Biochemistry.

Towards an understanding of the structural and functional properties of MscL, a mechanosensitive channel in bacteria

C. Kung, S. Nagle, S. Sukharev, 2004 .

Stoichiometry of the Large Conductance Bacterial Mechanosensitive Channel of E. coli. A Biochemical Study

S. Sukharev, D. McCaslin, S. I. Sukharev, 1999, The Journal of Membrane Biology.

Differential interactions of Piscidins with phospholipids and lipopolysaccharides at membrane interfaces.

Alison J. Scott, S. Sukharev, M. Cotten, 2020, Langmuir : the ACS journal of surfaces and colloids.

Biotechnology development for biomedical applications.

Stephen P. Buerger, Vincent De Sapio, Kirsten N. Cicotte, 2010 .

2,2,2-Trifluoroethanol changes the transition kinetics and subunit interactions in the small bacterial mechanosensitive channel MscS.

J. Killian, B. de Kruijff, S. Sukharev, 2007, Biophysical journal.

The Bacterial Mechanosensitive Channel MscS: Emerging Principles of Gating and Modulation

S. Sukharev, A. Anishkin, Bradley Akitake, 2007 .

Mechanosensitive channel MscS is critical for termination of the bacterial hypoosmotic permeability response

S. Sukharev, A. Anishkin, Anthony Schams, 2023, The Journal of general physiology.

Mechanosensitive channel MscS is critical for termination of the bacterial hypoosmotic permeability response

S. Sukharev, A. Anishkin, Anthony Schams, 2023, bioRxiv.

MSCS is a Critical Component for Osmotic Survival of Vibrio Cholerae

S. Sukharev, Blake Ushijima, A. Anishkin, 2020, Biophysical Journal.

Spatiotemporal relationships defining the adaptive gating of the bacterial mechanosensitive channel MscS

S. Sukharev, U. Çetiner, 2017, bioRxiv.

The cytoplasmic cage domain of the mechanosensitive channel MscS is a sensor of macromolecular crowding

S. Sukharev, K. Kamaraju, A. Anishkin, 2014, The Journal of general physiology.

The pathway and spatial scale for MscS inactivation

S. Sukharev, V. Belyy, K. Kamaraju, 2011, The Journal of general physiology.

Mechanosensitive Channel MscS in the Open State: Modeling of the Transition, Explicit Simulations, and Experimental Measurements of Conductance

Sergei Sukharev, S. Sukharev, Andriy Anishkin, 2008, The Journal of general physiology.

State-stabilizing Interactions in Bacterial Mechanosensitive Channel Gating and Adaptation*

Sergei Sukharev, S. Sukharev, Andriy Anishkin, 2009, The Journal of Biological Chemistry.

Mechanosensitive channels in bacteria as membrane tension reporters

S. Sukharev, 1999, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Partitioning of Seven Different Classes of Antibiotics into LPS Monolayers Supports Three Different Permeation Mechanisms through the Outer Bacterial Membrane.

Alison J. Scott, S. Rempe, S. Sukharev, 2021, Langmuir.

Effects on membrane lateral pressure suggest permeation mechanisms for bacterial quorum signaling molecules.

W. Bentley, S. Sukharev, Varnika Roy, 2011, Biochemistry.

High-Affinity Interactions of Beryllium(2+) with Phosphatidylserine Result in a Cross-Linking Effect Reducing Surface Recognition of the Lipid.

S. Sukharev, A. Dunina-Barkovskaya, Y. Ermakov, 2017, Biochemistry.

Isothermal Titration Calorimetry of Be2+ with Phosphatidylserine Models Guides All-Atom Force-Field Development for Lipid-Ion Interactions.

Jeffery B. Klauda, S. Sukharev, Alison N. Leonard, 2019, The journal of physical chemistry. B.

467—The reversible electrical breakdown of bilayer lipid membranes modified by uranyl ions

L. Chernomordik, Y. Chizmadzhev, S. Sukharev, 1982 .

The dynamic hypoosmotic response of Vibrio cholerae relies on the mechanosensitive channel MscS

S. Sukharev, A. Anishkin, Joseph Maramba, 2023, bioRxiv.

MscL, a Bacterial Mechanosensitive Channel

H. Guy, S. Sukharev, A. Anishkin, 2005 .

Membranetopology andmultimeric structure ofa mechanosensitive channel protein ofEscherichia coli

H. Guy, S. Sukharev, P. Blount, 1996 .