J. Huwyler

发表

Development of Covalent Chitosan-Polyethylenimine Derivatives as Gene Delivery Vehicle: Synthesis, Characterization, and Evaluation

L. Nicolle, J. Casper, Melanie Willimann, 2021, International journal of molecular sciences.

Engineered nanomaterial uptake and tissue distribution: from cell to organism

Peter Wick, Jörg Huwyler, P. Wick, 2013, International journal of nanomedicine.

Drug transport to brain with targeted liposomes

J. Huwyler, A. Schnyder, 2011, NeuroRX.

Regulation of BCRP (ABCG2) and P-Glycoprotein (ABCB1) by Cytokines in a Model of the Human Blood–Brain Barrier

S. Krähenbühl, J. Drewe, J. Huwyler, 2009, Cellular and Molecular Neurobiology.

Computational Prediction of Blood-Brain Barrier Permeability Using Decision Tree Induction

Jörg Huwyler, Felix Hammann, Claudia Suenderhauf, 2012, Molecules.

Selective stimulation of the JAK/STAT signaling pathway by silica nanoparticles in human endothelial cells.

J. Huwyler, H. Kettiger, E. Fasler-Kan, 2017, Toxicology in vitro : an international journal published in association with BIBRA.

Synthesis and biological evaluation of fenobam analogs as mGlu5 receptor antagonists.

W. Guba, B. Kuhn, W. Spooren, 2007, Bioorganic & medicinal chemistry letters.

Synthesis and characterization of 1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: Part 3. New potent non-competitive metabotropic glutamate receptor 2/3 antagonists.

J. Kew, T. Woltering, G. Adam, 2008, Bioorganic & medicinal chemistry letters.

Rational design, synthesis, and structure-activity relationship of benzoxazolones: new potent mglu5 receptor antagonists based on the fenobam structure.

W. Spooren, J. Peters, S. Ceccarelli, 2007, Bioorganic & medicinal chemistry letters.

Arylmethoxypyridines as novel, potent and orally active mGlu5 receptor antagonists.

W. Spooren, J. Peters, S. Ceccarelli, 2006, Bioorganic & medicinal chemistry letters.

Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases.

W. Guba, W. Spooren, J. Peters, 2015, Journal of medicinal chemistry.

Nanomaterials: Therapeutic Applications

Jörg Huwyler, Marine Camblin, Dominik Witzigmann, 2015 .

Rapid optimization of liposome characteristics using a combined microfluidics and design-of-experiment approach

Jörg Huwyler, Sandro Sieber, Mohammad-Ali Shahbazi, 2018, Drug Delivery and Translational Research.

Bioinspired Molecular Factories with Architecture and In Vivo Functionalities as Cell Mimics

C. Palivan, W. Meier, T. Einfalt, 2020, Advanced science.

Zebrafish as a predictive screening model to assess macrophage clearance of liposomes in vivo.

P. Detampel, J. Huwyler, D. Witzigmann, 2019, Nanomedicine : nanotechnology, biology, and medicine.

Zebrafish as an early stage screening tool to study the systemic circulation of nanoparticulate drug delivery systems in vivo

P. Detampel, J. Huwyler, D. Witzigmann, 2017, Journal of controlled release : official journal of the Controlled Release Society.

Comparative safety evaluation of silica-based particles.

J. Rosenholm, J. Huwyler, H. Kettiger, 2015, Toxicology in vitro : an international journal published in association with BIBRA.

Shedding Light on Metal-Based Nanoparticles in Zebrafish by Computed Tomography with Micrometer Resolution.

C. Alexiou, B. Müller, P. Detampel, 2020, Small.

Mechanisms of increased bioavailability through amorphous solid dispersions: a review

J. Huwyler, M. Puchkov, A. Schittny, 2019, Drug delivery.

PEG‐PCL‐based nanomedicines: A biodegradable drug delivery system and its application

J. Huwyler, D. Witzigmann, S. Sieber, 2017, Journal of controlled release : official journal of the Controlled Release Society.

Functionalized Solid-Sphere PEG-b-PCL Nanoparticles to Target Brain Capillary Endothelial Cells In Vitro

J. Huwyler, D. Witzigmann, C. Prescianotto-Baschong, 2016 .

Impact of Insoluble Separation Layer Mechanical Properties on Disintegration and Dissolution Kinetics of Multilayer Tablets

J. Huwyler, M. Puchkov, K. Hosoya, 2020, Pharmaceutics.

A cell-based, multiparametric sensor approach characterises drug-induced cytotoxicity in human liver HepG2 cells.

M. Hafner, J. Huwyler, H. Kettiger, 2013, Toxicology in vitro : an international journal published in association with BIBRA.

Mucoadhesive microparticles for local treatment of gastrointestinal diseases.

J. Huwyler, M. Puchkov, Roberto Bravo, 2016, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Microdosed midazolam for the determination of cytochrome P450 3A activity: Development and clinical evaluation of a buccal film.

W. Haefeli, S. Krähenbühl, J. Huwyler, 2019, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Hard X-ray microtomography of Zebrafish larvae

J. Huwyler, G. Schulz, Griffin Rodgers, 2021, International Conference on X-Ray Lasers 2020.

In vitro assessment of the formation of ceftriaxone-calcium precipitates in human plasma.

P. Detampel, J. Huwyler, H. Schmutz, 2011, Journal of pharmaceutical sciences.

Protein-Polydimethylsiloxane Particles in Liquid Vial Monoclonal Antibody Formulations Containing Poloxamer 188.

R. S. Kishore, J. Huwyler, W. Friess, 2020, Journal of pharmaceutical sciences.

Formation of lipid and polymer based gold nanohybrids using a nanoreactor approach

T. Pfohl, J. Huwyler, D. Witzigmann, 2015 .

By-passing of P-glycoprotein Using Immunoliposomes

J. Drewe, J. Huwyler, A. Eberle, 2002, Journal of drug targeting.

Sub-visible particulate contamination in cell therapy products - Can we distinguish?

J. Huwyler, D. Jere, Hanns‐Christian Mahler, 2019, Journal of pharmaceutical sciences.

Current In Vitro Methods to Determine Hepatic Kpuu: A Comparison of Their Usefulness and Limitations.

J. Huwyler, G. Camenisch, B. Poller, 2017, Journal of pharmaceutical sciences.

DNA-directed arrangement of soft synthetic compartments and their behavior in vitro and in vivo.

C. Palivan, T. Einfalt, J. Huwyler, 2020, Nanoscale.

Characterization of new functionalized calcium carbonate-polycaprolactone composite material for application in geometry-constrained drug release formulation development

J. Huwyler, M. Puchkov, J. Schoelkopf, 2017, Drug development and industrial pharmacy.

Duloxetine Inhibits Effects of MDMA (“Ecstasy") In Vitro and in Humans in a Randomized Placebo-Controlled Laboratory Study

S. Krähenbühl, M. Liechti, J. Huwyler, 2012, PloS one.

Targeting of daunomycin using biotinylated immunoliposomes: Pharmacokinetics, tissue distribution and in vitro pharmacological effects

S. Krähenbühl, J. Drewe, J. Huwyler, 2005, Journal of drug targeting.

Oxantel pamoate-albendazole for Trichuris trichiura infection.

J. Utzinger, J. Keiser, S. Ame, 2014, The New England journal of medicine.

Biocompatible polymer-Peptide hybrid-based DNA nanoparticles for gene delivery.

W. Meier, J. Huwyler, V. Balasubramanian, 2015, ACS applied materials & interfaces.

Induction of cytochrome P450 3A4 and P-glycoprotein by the isoxazolyl-penicillin antibiotic flucloxacillin.

J. Huwyler, M. Wright, H. Gutmann, 2006, Current drug metabolism.

Evaluation of the pharmacokinetic profile of artesunate, artemether and their metabolites in sheep naturally infected with Fasciola hepatica.

J. Keiser, L. Rinaldi, G. Cringoli, 2012, Veterinary parasitology.

Development and validation of a liquid chromatography and ion spray tandem mass spectrometry method for the quantification of artesunate, artemether and their major metabolites dihydroartemisinin and dihydroartemisinin-glucuronide in sheep plasma.

J. Keiser, J. Huwyler, U. Duthaler, 2011, Journal of mass spectrometry : JMS.

Development and validation of a liquid chromatography/mass spectrometry method for pharmacokinetic studies of OZ78, a fasciocidal drug candidate.

J. Keiser, J. Huwyler, C. Kirchhofer, 2010, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Pooled Population Pharmacokinetic Analysis of Tribendimidine for the Treatment of Opisthorchis viverrini Infections

J. Keiser, M. Penny, J. Huwyler, 2019, Antimicrobial Agents and Chemotherapy.

Pharmacokinetics and phenotyping properties of the Basel phenotyping cocktail combination capsule in healthy male adults

S. Krähenbühl, J. Huwyler, M. Haschke, 2019, British journal of clinical pharmacology.

CombiCap: A novel drug formulation for the basel phenotyping cocktail.

S. Krähenbühl, J. Huwyler, M. Haschke, 2016, International journal of pharmaceutics.

Polymersomes conjugated to 83-14 monoclonal antibodies: in vitro targeting of brain capillary endothelial cells.

C. Palivan, J. Huwyler, V. Balasubramanian, 2014, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Interactions between silica nanoparticles and phospholipid membranes.

J. Huwyler, H. Kettiger, Gabriela Québatte, 2016, Biochimica et biophysica acta.

On-line identification of P-glycoprotein substrates by monitoring of extracellular acidification and respiration rates in living cells.

M. Hafner, J. Huwyler, A. Treiber, 2011, Biochimica et biophysica acta.

Stable human brain microvascular endothelial cell line retaining its barrier‐specific nature independent of the passage number

T. Kanda, J. Huwyler, F. Shimizu, 2013 .

Improvement of DNA Vector Delivery of DOTAP Lipoplexes by Short-Chain Aminolipids

H. M. Grisch-Chan, B. Thöny, J. Huwyler, 2020, ACS omega.

Pharmacokinetics of the fasciocidal drug candidates MT04 and OZ78 in uninfected rats and in vitro pharmacodynamic studies.

J. Keiser, J. Huwyler, M. Vargas, 2012, International journal for parasitology. Drugs and drug resistance.

Spontaneous In Situ Formation of Liposomes from Inert Porous Microparticles for Oral Drug Delivery

J. Huwyler, M. Puchkov, J. Schoelkopf, 2020, Pharmaceutics.

Oral delivery of vancomycin by tetraether lipid liposomes

J. Huwyler, G. Hofhaus, D. Witzigmann, 2017, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Efficacy and tolerability of moxidectin alone and in co-administration with albendazole and tribendimidine versus albendazole plus oxantel pamoate against Trichuris trichiura infections: a randomised, non-inferiority, single-blind trial.

J. Keiser, S. Ame, J. Huwyler, 2018, The Lancet. Infectious diseases.

Efficacy and safety of tribendimidine, tribendimidine plus ivermectin, tribendimidine plus oxantel pamoate, and albendazole plus oxantel pamoate against hookworm and concomitant soil-transmitted helminth infections in Tanzania and Côte d'Ivoire: a randomised, controlled, single-blinded, non-inferior

J. Keiser, J. Coulibaly, S. Ame, 2017, The Lancet. Infectious diseases.

LC-MS/MS method for the determination of two metabolites of tribendimidine, deacylated amidantel and its acetylated metabolite in plasma, blood and dried blood spots.

J. Keiser, J. Huwyler, U. Duthaler, 2015, Journal of pharmaceutical and biomedical analysis.

Treatment of large solid tumors in mice with daunomycin-loaded sterically stabilized liposomes.

J. Huwyler, W. Pardridge, P. L. Golden, 1998, Drug delivery.

Efficacy and tolerability of triple drug therapy with albendazole, pyrantel pamoate, and oxantel pamoate compared with albendazole plus oxantel pamoate, pyrantel pamoate plus oxantel pamoate, and mebendazole plus pyrantel pamoate and oxantel pamoate against hookworm infections in school-aged childre

J. Keiser, J. Huwyler, J. Hattendorf, 2018, The Lancet. Infectious diseases.

4-Hydroxynonenal is An Oxidative Degradation Product of Polysorbate 80.

J. Huwyler, A. Koulov, M. Jahn, 2021, Journal of pharmaceutical sciences.

Uptake of Cationized Albumin Coupled Liposomes by Cultured Porcine Brain Microvessel Endothelial Cells and Intact Brain Capillaries

J. Huwyler, G. Fricker, S. Nobmann, 2002, Journal of drug targeting.

Isolation of multiantennary N-glycans from glycoproteins for hepatocyte specific targeting via the asialoglycoprotein receptor

P. Detampel, J. Huwyler, D. Witzigmann, 2016 .

Design, synthesis and characterization of a paclitaxel formulation activated by extracellular MMP9.

H. E. Meyer zu Schwabedissen, J. Huwyler, M. Hamburger, 2020, Bioconjugate chemistry.

Drug transport to brain with targeted liposomes

J. Huwyler, A. Schnyder, 2005 .

Evidence for P‐glycoprotein‐modulated penetration of morphine‐6‐glucuronide into brain capillary endothelium

J. Drewe, J. Huwyler, G. Fricker, 1996, British journal of pharmacology.

Self‐assembling chitosan hydrogel: A drug‐delivery device enabling the sustained release of proteins

P. Detampel, J. Huwyler, Fabiola Porta, 2018 .

Drug loading into porous calcium carbonate microparticles by solvent evaporation.

J. Huwyler, M. Puchkov, F. Varum, 2014, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Propagation-based X-ray Phase Contrast Microtomography of Zebrafish Embryos to Understand Drug Delivery

A. Rack, H. Deyhle, P. Thalmann, 2018, Microscopy and Microanalysis.

Investigation of Disintegration and Dissolution Behavior of Mefenamic Acid Drug Formulation Using Numeric Solution of Noyes-Whitney Equation with Cellular Automata Model on Microtomographic Surfaces and Rational Arrangements of Tablet Components

J. Huwyler, C. Schlepütz, M. Puchkov, 2018 .

Marker-ion analysis for quantification of mucoadhesivity of microparticles in particle-retention assays.

J. Huwyler, M. Puchkov, F. Varum, 2015, International journal of pharmaceutics.

Part I: Significant reduction of lyophilization process times by using novel matrix based scaffolds.

J. Huwyler, D. Kullmann, Carmen Lema Martinez, 2022, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Part II: Matrix based scaffold lyophilization facilitates processing as a prerequisite for an innovative packaging system.

J. Huwyler, D. Kullmann, Carmen Lema Martinez, 2022, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Buprenorphine loaded PLGA microparticles: Characterization of a sustained-release formulation

P. Jirkof, P. Detampel, J. Huwyler, 2021 .

9H-Xanthene-9-carboxylic acid [1,2,4]oxadiazol-3-yl- and (2H-tetrazol-5-yl)-amides as potent, orally available mGlu1 receptor enhancers.

V. Mutel, F. Knoflach, J. Huwyler, 2005, Bioorganic & medicinal chemistry letters.

5-hydroxyindole-2-carboxylic acid amides: novel histamine-3 receptor inverse agonists for the treatment of obesity.

J. Huwyler, S. Raab, F. Schuler, 2009, Journal of medicinal chemistry.

HIV protease inhibitor ritonavir: a more potent inhibitor of P-glycoprotein than the cyclosporine analog SDZ PSC 833.

C. Beglinger, J. Drewe, J. Huwyler, 1999, Biochemical pharmacology.

Fluorinated 9H-xanthene-9-carboxylic acid oxazol-2-yl-amides as potent, orally available mGlu1 receptor enhancers.

V. Mutel, F. Knoflach, J. Huwyler, 2009, Bioorganic & medicinal chemistry letters.

Transferrin-conjugated liposome targeting of photosensitizer AlPcS4 to rat bladder carcinoma cells.

Jörg Huwyler, Peter A M de Witte, Dirk De Vos, 2004, Journal of the National Cancer Institute.

Compaction of functionalized calcium carbonate, a porous and crystalline microparticulate material with a lamellar surface.

P. Gane, J. Huwyler, M. Puchkov, 2014, International journal of pharmaceutics.

Nanomedicine in cancer therapy: challenges, opportunities, and clinical applications.

Jörg Huwyler, Andreas Wicki, Dominik Witzigmann, 2015, Journal of controlled release : official journal of the Controlled Release Society.

Efficacy and safety of ascending dosages of moxidectin and moxidectin-albendazole against Trichuristrichiura in adolescents: a randomized controlled trial.

J. Keiser, S. Ame, J. Huwyler, 2019, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Efficacy and safety of oxantel pamoate in school-aged children infected with Trichuris trichiura on Pemba Island, Tanzania: a parallel, randomised, controlled, dose-ranging study.

J. Keiser, S. Ame, J. Huwyler, 2016, The Lancet. Infectious diseases.

Cryoprotection in Human Mesenchymal Stromal/Stem Cells: Synergistic Impact of Urea and Glucose.

J. Huwyler, D. Jere, Lea L Sorret, 2023, Journal of pharmaceutical sciences.

Human cytokines activate JAK–STAT signaling pathway in porcine ocular tissue

J. Flammer, J. Huwyler, N. Barteneva, 2013, Xenotransplantation.

The use of 4-Hexylresorcinol as antibiotic adjuvant

J. Huwyler, S. Sidorenko, V. Gostev, 2020, PloS one.

Biomimetic artificial organelles with in vitro and in vivo activity triggered by reduction in microenvironment

A. Najer, C. Palivan, T. Einfalt, 2018, Nature Communications.

Efficacy and safety of albendazole plus ivermectin, albendazole plus mebendazole, albendazole plus oxantel pamoate, and mebendazole alone against Trichuris trichiura and concomitant soil-transmitted helminth infections: a four-arm, randomised controlled trial.

I. Bogoch, J. Utzinger, J. Keiser, 2015, The Lancet. Infectious diseases.

Pharmacokinetic Study of Praziquantel Enantiomers and Its Main Metabolite R-trans-4-OH-PZQ in Plasma, Blood and Dried Blood Spots in Opisthorchis viverrini-Infected Patients

J. Keiser, J. Huwyler, P. Odermatt, 2016, PLoS neglected tropical diseases.

Indocyanine green loaded biocompatible nanoparticles: Stabilization of indocyanine green (ICG) using biocompatible silica-poly(ε-caprolactone) grafted nanocomposites

M. Frenz, J. Huwyler, U. Pieles, 2013 .

Functionalized Calcium Carbonate as a Novel Pharmaceutical Excipient for the Preparation of Orally Dispersible Tablets

J. Huwyler, M. Puchkov, D. E. Gerard, 2013, Pharmaceutical Research.

Functionalized calcium carbonate microparticles for the delivery of proteins

J. Huwyler, M. Puchkov, J. Schoelkopf, 2018, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Scientific Basis for Regulatory Decision-Making of Nanomaterials Report on the Workshop, 20-21 January 2014, Center of Applied Ecotoxicology, Dübendorf.

Christoph Studer, Peter Wick, Jörg Huwyler, 2015, Chimia.

Directing Nanoparticle Biodistribution through Evasion and Exploitation of Stab2-Dependent Nanoparticle Uptake

A. Kros, J. Huwyler, Frederick Campbell, 2018, ACS nano.

Lipid-Based DNA Therapeutics: Hallmarks of Non-Viral Gene Delivery.

P. Cullis, J. Huwyler, D. Witzigmann, 2019, ACS nano.

In vitro investigation on the impact of the surface-active excipients Cremophor EL, Tween 80 and Solutol HS 15 on the metabolism of midazolam.

Jörg Huwyler, Isabelle Walter, J. Huwyler, 2004, Biopharmaceutics & drug disposition.

In Vitro and In Vivo Drug-Drug Interaction Study of the Effects of Ivermectin and Oxantel Pamoate on Tribendimidine

J. Keiser, J. Huwyler, Jessica D. Schulz, 2018, Antimicrobial Agents and Chemotherapy.

oColonic delivery of metronidazole-loaded capsules for local treatment of bacterial infections: a clinical pharmacoscintigraphy study.

J. Huwyler, M. Haschke, D. Wild, 2021, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

High Acceptability of an Orally Dispersible Tablet Formulation by Children

J. Huwyler, J. Bielicki, M. Puchkov, 2021, Children.

Challenges for cell-based medicinal products from a pharmaceutical product perspective.

Jörg Huwyler, Hanns-Christian Mahler, Dhananjay Jere, 2020, Journal of pharmaceutical sciences.

Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery.

Jörg Huwyler, Holger Fischer, J. Huwyler, 2003, Journal of medicinal chemistry.

Relevance of p‐glycoprotein for the enteral absorption of cyclosporin A: in vitro‐in vivo correlation

C. Beglinger, J. Drewe, J. Huwyler, 1996, British journal of pharmacology.

A Binary Ant Colony Optimization Classifier for Molecular Activities

Jörg Huwyler, Felix Hammann, Claudia Suenderhauf, 2011, J. Chem. Inf. Model..

Design and Characterization of Mutated Variants of the Oncotoxic Parvoviral Protein NS1

J. Huwyler, J. Nüesch, K. Buczak, 2023, Viruses.

Zebrafish as a preclinical in vivo screening model for nanomedicines.

Jörg Huwyler, Sandro Sieber, Alexander Kros, 2019, Advanced drug delivery reviews.

[Significance of flexibility in ballet dancers].

J. Huwyler, 1984, Der Orthopade.

Efficacy and Safety of Ivermectin Against Trichuris trichiura in Preschool-aged and School-aged Children: A Randomized Controlled Dose-finding Trial

J. Keiser, J. Coulibaly, J. Huwyler, 2018, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Efficacy of Moxidectin Versus Ivermectin Against Strongyloides stercoralis Infections: A Randomized, Controlled Noninferiority Trial

J. Keiser, J. Huwyler, P. Odermatt, 2017, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Efficacy, safety and pharmacokinetics of 1,2,4-trioxolane OZ78 against an experimental infection with Fasciola hepatica in sheep.

J. Keiser, R. Kaminsky, J. Huwyler, 2010, Veterinary parasitology.

Efficacy and pharmacokinetics of OZ78 and MT04 against a natural infection with Fasciola hepatica in sheep.

J. Keiser, L. Rinaldi, G. Cringoli, 2013, Veterinary parasitology.

Pharmacokinetics of a Pediatric Tribendimidine Dose-Finding Study To Treat Hookworm Infection in African Children

P. Bonate, J. Keiser, J. Coulibaly, 2018, Antimicrobial Agents and Chemotherapy.

Transport of clonidine across cultured brain microvessel endothelial cells.

J. Drewe, J. Huwyler, G. Fricker, 1997, The Journal of pharmacology and experimental therapeutics.

Modulation of transendothelial permeability and expression of ATP-binding cassette transporters in cultured brain capillary endothelial cells by astrocytic factors and cell-culture conditions

J. Drewe, J. Huwyler, G. Fricker, 2003, Experimental Brain Research.

Transport of the β-Lactam Antibiotic Benzylpenicillin and the Dipeptide Glycylsarcosine by Brain Capillary Endothelial Cells In Vitro

J. Drewe, J. Huwyler, G. Fricker, 1998 .

TRANSPORT OF THE b-LACTAM ANTIBIOTIC BENZYLPENICILLIN AND THE DIPEPTIDE GLYCYLSARCOSINE BY BRAIN CAPILLARY ENDOTHELIAL CELLS IN VITRO

J. Drewe, J. Huwyler, G. Fricker, 1998 .

Variable asialoglycoprotein receptor 1 expression in liver disease: Implications for therapeutic intervention

L. Terracciano, C. Quintavalle, J. Huwyler, 2016, Hepatology research : the official journal of the Japan Society of Hepatology.

High-performance liquid chromatographic method for an automated determination of local anaesthetics in human plasma.

J. Drewe, J. Huwyler, E. Küsters, 1997, Journal of chromatography. B, Biomedical sciences and applications.

Mechanistic insights into effect of surfactants on oral bioavailability of amorphous solid dispersions.

P. Detampel, J. Huwyler, M. Puchkov, 2020, Journal of controlled release : official journal of the Controlled Release Society.

A combined mathematical model linking the formation of amorphous solid dispersions with hot‐melt‐extrusion process parameters

J. Huwyler, M. Puchkov, A. Schittny, 2018, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Brain drug delivery of small molecules using immunoliposomes.

J. Huwyler, W. Pardridge, Dafang Wu, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Pediatric Dispersible Tablets: a Modular Approach for Rapid Prototyping

Jörg Huwyler, Jonas Buck, Peter Kühl, 2016, Pharmaceutical Research.

Functionalized Calcium Carbonate as a Novel Pharmaceutical Excipient for the Preparation of Orally Dispersible Tablets

J. Huwyler, N. D. Maiuta, M. Puchkov, 2013, Pharmaceutical Research.

In silico and in vitro methods to optimize the performance of experimental gastroretentive floating mini-tablets

Jörg Huwyler, Maxim Puchkov, Joachim Schoelkopf, 2016, Drug development and industrial pharmacy.

Modeling of Disintegration and Dissolution Behavior of Mefenamic Acid Formulation Using Numeric Solution of Noyes-Whitney Equation with Cellular Automata on Microtomographic and Algorithmically Generated Surfaces

J. Huwyler, C. Schlepütz, M. Puchkov, 2018, Pharmaceutics.

In vitro characterization and mouthfeel study of functionalized calcium carbonate in orally disintegrating tablets.

J. Huwyler, M. Puchkov, J. Schoelkopf, 2017, International journal of pharmaceutics.

Modulation of multidrug resistance protein expression in porcine brain capillary endothelial cells in vitro.

C. Beglinger, J. Drewe, J. Huwyler, 1999, Drug metabolism and disposition: the biological fate of chemicals.

Particle Forming Amorphous Solid Dispersions: A Mechanistic Randomized Pharmacokinetic Study in Humans

S. Krähenbühl, J. Huwyler, U. Duthaler, 2021, Pharmaceutics.

Combined cerium oxide nanocapping and layer-by-layer coating of porous silicon containers for controlled drug release

J. Huwyler, M. Shahbazi, D. Witzigmann, 2018, Journal of Materials Science.

The human brain endothelial cell line hCMEC/D3 as a human blood‐brain barrier model for drug transport studies

S. Krähenbühl, P. Couraud, J. Drewe, 2008, Journal of neurochemistry.

Impact of solutol HS 15 on the pharmacokinetic behaviour of colchicine upon intravenous administration to male Wistar rats

J. Huwyler, I. Walter, B. Bittner, 2003, Biopharmaceutics & drug disposition.

Cytokine signaling in the human brain capillary endothelial cell line hCMEC/D3

J. Huwyler, N. Barteneva, C. Suenderhauf, 2010, Brain Research.

ATP-induced cellular stress and mitochondrial toxicity in cells expressing purinergic P2X7 receptor

S. Krähenbühl, M. Hafner, J. Huwyler, 2015, Pharmacology research & perspectives.

Controlled Tyrosine Kinase Inhibitor Delivery to Liver Cancer Cells by Gate-Capped Mesoporous Silica Nanoparticles.

T. Einfalt, J. Huwyler, M. Shahbazi, 2019, ACS applied bio materials.

Non-viral gene delivery of the oncotoxic protein NS1 for treatment of hepatocellular carcinoma.

W. Berger, S. Krähenbühl, L. Terracciano, 2021, Journal of controlled release : official journal of the Controlled Release Society.

Assessing the Risk of Drug-Induced Cholestasis Using Unbound Intrahepatic Concentrations

J. Huwyler, G. Camenisch, B. Poller, 2017, Drug Metabolism and Disposition.

Drug targeting using OX7-immunoliposomes: Correlation between Thy1.1 antigen expression and tissue distribution in the rat

J. Huwyler, E. Waelti, H. Marti, 2008 .

Rapid and highly automated determination of morphine and morphine glucuronides in plasma by on-line solid-phase extraction and column liquid chromatography.

J. Drewe, J. Huwyler, E. Küsters, 1995, Journal of chromatography. B, Biomedical applications.

PDMS‐b‐PMOXA polymersomes for hepatocyte targeting and assessment of toxicity

J. Huwyler, D. Witzigmann, Fabiola Porta, 2017, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Hepatocyte targeting using pegylated asialofetuin-conjugated liposomes

S. Krähenbühl, P. Detampel, J. Huwyler, 2014, Journal of drug targeting.

Immunoliposome targeting to mesangial cells: a promising strategy for specific drug delivery to the kidney.

Jörg Huwyler, J. Huwyler, E. Waelti, 2005, Journal of the American Society of Nephrology : JASN.

Interaction of the antiviral drug telaprevir with renal and hepatic drug transporters.

Jörg Huwyler, J. Huwyler, Gian Camenisch, 2012, Biochemical pharmacology.

Extensive Chemical Modifications in the Primary Protein Structure of IgG1 Subvisible Particles Are Necessary for Breaking Immune Tolerance.

J. Huwyler, A. Koulov, Patrick Bulau, 2017, Molecular pharmaceutics.

Selective Oxidation of Methionine and Tryptophan Residues in a Therapeutic IgG1 Molecule.

Jörg Huwyler, Hanns-Christian Mahler, Christof Finkler, 2015, Journal of pharmaceutical sciences.

Targeting of skeletal muscle in vitro using biotinylated immunoliposomes.

J. Drewe, J. Huwyler, A. Schnyder, 2004, The Biochemical journal.

Receptor mediated delivery of daunomycin using immunoliposomes: pharmacokinetics and tissue distribution in the rat.

J. Huwyler, W. Pardridge, J. Yang, 1997, The Journal of pharmacology and experimental therapeutics.

Application of the extended clearance concept classification system (ECCCS) to predict the victim drug-drug interaction potential of statins

J. Huwyler, G. Camenisch, B. Poller, 2015, Drug metabolism and personalized therapy.

Targeting of the photocytotoxic compound AlPcS4 to hela cells by transferrin conjugated peg‐liposomes

D. D. De Vos, L. Missiaen, J. Huwyler, 2002, International journal of cancer.

Single-Ascending-Dose Pharmacokinetic Study of Tribendimidine in Opisthorchis viverrini-Infected Patients

J. Keiser, M. Penny, J. Huwyler, 2016, Antimicrobial Agents and Chemotherapy.

High-throughput viscosity measurement using capillary electrophoresis instrumentation and its application to protein formulation.

J. Huwyler, Andrea Allmendinger, Stefan Fischer, 2014, Journal of pharmaceutical and biomedical analysis.

Development and validation of an enantioselective LC-MS/MS method for the analysis of the anthelmintic drug praziquantel and its main metabolite in human plasma, blood and dried blood spots.

J. Keiser, J. Huwyler, U. Duthaler, 2016, Journal of pharmaceutical and biomedical analysis.

Prediction of Organic Anion-Transporting Polypeptide 1B1- and 1B3-Mediated Hepatic Uptake of Statins Based on Transporter Protein Expression and Activity Data

J. Huwyler, G. Camenisch, B. Poller, 2014, Drug Metabolism and Disposition.

Optimization-by-design of hepatotropic lipid nanoparticles targeting the sodium-taurocholate cotransporting polypeptide

H. E. Meyer zu Schwabedissen, T. Einfalt, J. Huwyler, 2019, eLife.

Drug interaction potential of resveratrol

S. Krähenbühl, P. Detampel, J. Huwyler, 2012, Drug metabolism reviews.

Preclinical hazard evaluation strategy for nanomedicines

Stefan Siegrist, Emre Cörek, Pascal Detampel, 2018, Nanotoxicology.

Study of Drug Particle Distributions within Mini-tablets Using Synchrotron X-ray Microtomography and Superpixel Image Clustering.

J. Keiser, J. Huwyler, C. Schlepütz, 2019, International journal of pharmaceutics.

Efficacy and Safety of Moxidectin, Synriam, Synriam-Praziquantel versus Praziquantel against Schistosoma haematobium and S. mansoni Infections: A Randomized, Exploratory Phase 2 Trial

J. Keiser, J. Coulibaly, J. Huwyler, 2016, PLoS neglected tropical diseases.

Polymersomes containing quantum dots for cellular imaging

P. Detampel, J. Huwyler, H. Kettiger, 2014, International journal of nanomedicine.

Polymersomes containing quantum dots for cellular imaging Marine camblin

P. Detampel, J. Huwyler, H. Kettiger, 2014 .

Floating gastroretentive drug delivery systems: Comparison of experimental and simulated dissolution profiles and floatation behavior.

P. Gane, J. Huwyler, M. Puchkov, 2014, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Rapid optimization of liposome characteristics using a combined microfluidics and design-of-experiment approach

J. Huwyler, M. Shahbazi, D. Witzigmann, 2018, Drug Delivery and Translational Research.

Improved oral bioavailability of cyclosporin A in male Wistar rats. Comparison of a Solutol HS 15 containing self-dispersing formulation and a microsuspension.

J. Huwyler, I. Walter, B. Bittner, 2002, International journal of pharmaceutics.

Computational aqueous solubility prediction for drug-like compounds in congeneric series.

Jörg Huwyler, Manfred Kansy, Lei Du-Cuny, 2008, European journal of medicinal chemistry.

Poly(Sarcosine) Surface Modification Imparts Stealth-Like Properties to Liposomes.

J. Huwyler, S. Barnert, D. Witzigmann, 2019, Small.

Determination of the Density of Protein Particles Using a Suspended Microchannel Resonator.

Jörg Huwyler, Hanns-Christian Mahler, Christof Finkler, 2015, Journal of pharmaceutical sciences.

New IVIVE method for the prediction of total human clearance and relative elimination pathway contributions from in vitro hepatocyte and microsome data.

J. Huwyler, G. Camenisch, K. Umehara, 2016, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

The extended clearance model and its use for the interpretation of hepatobiliary elimination data

Jörg Huwyler, J. Huwyler, Gian Camenisch, 2015 .

Activation of the JAK-STAT intracellular pathway in human retinal pigment epithelial cell line ARPE-19

J. Flammer, J. Huwyler, N. Barteneva, 2010 .

Secreted Matrix Metalloproteinase-9 of Proliferating Smooth Muscle Cells as a Trigger for Drug Release from Stent Surface Polymers in Coronary Arteries.

A. Schmidt, Timo Glatter, H. E. Meyer zu Schwabedissen, 2016, Molecular pharmaceutics.

The effect of the mGlu5 receptor antagonist MPEP in rodent tests of anxiety and cognition: a comparison

W. Spooren, J. Huwyler, E. Prinssen, 2005, Psychopharmacology.

Synthesis and characterization of 1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: Part 4. In vivo active potent and selective non-competitive metabotropic glutamate receptor 2/3 antagonists.

T. Woltering, F. Knoflach, S. Gatti, 2010, Bioorganic & medicinal chemistry letters.

Pharmacokinetics of the Antischistosomal Lead Ozonide OZ418 in Uninfected Mice Determined by Liquid Chromatography-Tandem Mass Spectrometry

J. Keiser, J. Huwyler, A. Leonidova, 2016, Antimicrobial Agents and Chemotherapy.

Pharmacokinetics of the antischistosomal lead OZ418 in uninfected mice determined by LC-MS/MS

J. Keiser, J. Huwyler, A. Leonidova, 2016 .

Combinatorial QSAR modeling of human intestinal absorption.

Jörg Huwyler, Andreas Maunz, Christoph Helma, 2011, Molecular pharmaceutics.

Immobilization of Enzymes on PLGA Sub-Micrometer Particles by Crosslinked Layer-by-Layer Deposition.

Jörg Huwyler, Sandro Sieber, S. Schwarz, 2017, Macromolecular bioscience.

Microsoft Word-88502077-file00

J. Huwyler, G. Camenisch, B. Poller, 2014 .

Metamizole is a Moderate Cytochrome P450 Inducer Via the Constitutive Androstane Receptor and a Weak Inhibitor of CYP1A2

S. Krähenbühl, H. E. Meyer zu Schwabedissen, J. Huwyler, 2020, Clinical pharmacology and therapeutics.

Tumor targeting using liposomal antineoplastic drugs

Jörg Huwyler, Stephan Krähenbühl, S. Krähenbühl, 2008, International journal of nanomedicine.

In vitro-in vivo extrapolation method to predict human renal clearance of drugs.

Jörg Huwyler, J. Huwyler, Gian Camenisch, 2014, Journal of pharmaceutical sciences.

In silico prediction of brain and CSF permeation of small molecules using PLS regression models.

Jörg Huwyler, Manfred Kansy, Stefanie Bendels, 2008, European journal of medicinal chemistry.

Three-dimensional x-ray microscopy of zebrafish larvae

Christine Tanner, Emre Cörek, Jörg Huwyler, 2021, Smart Structures and Materials + Nondestructive Evaluation and Health Monitoring.

Design and in vivo evaluation of a microparticulate depot formulation of buprenorphine for veterinary use

P. Jirkof, M. Arras, P. Detampel, 2020, Scientific Reports.

Loading of Porous Functionalized Calcium Carbonate Microparticles: Distribution Analysis with Focused Ion Beam Electron Microscopy and Mercury Porosimetry

J. Huwyler, M. Puchkov, J. Schoelkopf, 2019, Pharmaceutics.

Discovery of potent and selective histamine H3 receptor inverse agonists based on the 3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one scaffold.

J. Huwyler, S. Raab, F. Schuler, 2010, Bioorganic & medicinal chemistry letters.

Stability investigation of FCC-based tablets for oral suspension with caffeine and oxantel pamoate as model drugs

J. Huwyler, M. Puchkov, J. Schoelkopf, 2018, Drug Development and Industrial Pharmacy.

Arylmethoxypyridines as novel, potent and orally active mGlu5 receptor antagonists.

W. Spooren, J. Peters, S. Ceccarelli, 2006, Bioorganic & medicinal chemistry letters.

Modulation of morphine-6-glucuronide penetration into the brain by P-glycoprotein.

J. Drewe, J. Huwyler, G. Fricker, 1998, International journal of clinical pharmacology and therapeutics.

Low Volume Aseptic Filling: Impact of Pump Systems on Shear Stress.

J. Huwyler, Julien Boeuf, Tim Dreckmann, 2019, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Characterization of transferrin receptor in an immortalized cell line of rat brain endothelial cells, RBE4.

J. Huwyler, A. Eberle, S. Froidevaux, 1999, Journal of receptor and signal transduction research.

Brain‐Specific Drug Targeting Strategies

J. Huwyler, U. Bickel, Young-Sook Kang, 2001 .

Histamine-3 Receptor Inverse Agonists for the Treatment of Obesity: Validation of the Target and Identification of Novel Series

J. Huwyler, S. Raab, F. Schuler, 2009 .

Secreted Matrix Metalloproteinase-9 of Proliferating Smooth Muscle Cells as a Trigger for Drug Release from Stent Surface Polymers in Coronary Arteries.

A. Schmidt, Timo Glatter, J. Huwyler, 2016, Molecular pharmaceutics.

Comparative safety evaluation of silica-based particles.

J. Rosenholm, J. Huwyler, D. Şen Karaman, 2015, Toxicology in vitro : an international journal published in association with BIBRA.

Impact of non-ideal analyte behavior on the separation of protein aggregates by asymmetric flow field-flow fractionation.

J. Huwyler, Atanas V. Koulov, Christof Finkler, 2018, Journal of separation science.