J. G. García Fernández

发表

Trifaceted Mickey Mouse Amphiphiles for Programmable Self‐Assembly, DNA Complexation and Organ‐Selective Gene Delivery

Ana I. Carbajo‐Gordillo, M. González-Cuesta, J. L. Jiménez Blanco, 2021, Chemistry.

Molecular determinants for cyclo-oligosaccharide-based nanoparticle-mediated effective siRNA transfection.

F. González-Nilo, J. L. Jiménez Blanco, J. G. García Fernández, 2017, Nanomedicine.

Cyclodextrin- and calixarene-based polycationic amphiphiles as gene delivery systems: a structure-activity relationship study.

V. Franceschi, G. Donofrio, F. Sansone, 2015, Organic & biomolecular chemistry.

Polycationic amphiphilic cyclodextrins as gene vectors: effect of the macrocyclic ring size on the DNA complexing and delivery properties.

J. L. Jiménez Blanco, C. Di Giorgio, C. Ortiz Mellet, 2012, Organic & biomolecular chemistry.

β-Cyclodextrin-based polycationic amphiphilic "click" clusters: effect of structural modifications in their DNA complexing and delivery properties.

F. Santoyo-González, C. Di Giorgio, C. Ortiz Mellet, 2011, The Journal of organic chemistry.

Cyclodextrin-based gene delivery systems.

J. M. Benito, C. Ortiz Mellet, J. G. García Fernández, 2011, Chemical Society reviews.

Polycationic amphiphilic cyclodextrins for gene delivery: synthesis and effect of structural modifications on plasmid DNA complex stability, cytotoxicity, and gene expression.

Nicolas Guilloteau, Alejandro Díaz-Moscoso, J. M. Benito, 2009, Chemistry.

Preorganized macromolecular gene delivery systems: amphiphilic beta-cyclodextrin "click clusters".

F. Santoyo-González, R. Salto, M. Girón, 2009, Organic & biomolecular chemistry.

Revealing cooperative binding of polycationic cyclodextrins with DNA oligomers by capillary electrophoresis coupled to mass spectrometry.

J. M. Benito, C. Przybylski, J. G. García Fernández, 2018, Analytica chimica acta.

Conformationally-locked N-glycosides with selective β-glucosidase inhibitory activity: identification of a new non-iminosugar-type pharmacological chaperone for Gaucher disease.

Yoshiyuki Suzuki, K. Higaki, E. Nanba, 2012, Journal of medicinal chemistry.

Pharmacological chaperone therapy for Gaucher disease: a patent review

J. M. Benito, J. G. García Fernández, C. O. Mellet, 2011, Expert opinion on therapeutic patents.

A Fluorescent sp2‐Iminosugar With Pharmacological Chaperone Activity for Gaucher Disease: Synthesis and Intracellular Distribution Studies

Yoshiyuki Suzuki, K. Higaki, E. Nanba, 2010, Chembiochem : a European journal of chemical biology.

Chaperone Activity of Bicyclic Nojirimycin Analogues for Gaucher Mutations in Comparison with N‐(n‐nonyl)Deoxynojirimycin

Yoshiyuki Suzuki, K. Higaki, C. Ortiz Mellet, 2009, Chembiochem : a European journal of chemical biology.

Glycomimetic-based pharmacological chaperones for lysosomal storage disorders: lessons from Gaucher, GM1-gangliosidosis and Fabry diseases.

J. G. García Fernández, C. O. Mellet, E. Sánchez-Fernández, 2016, Chemical communications.

Synthesis of polyfluoroalkyl sp2-iminosugar glycolipids and evaluation of their immunomodulatory properties towards anti-tumor, anti-leishmanial and anti-inflammatory therapies.

F. Gamarro, C. Ortiz Mellet, J. G. García Fernández, 2019, European journal of medicinal chemistry.

The sp2-iminosugar glycolipid 1-dodecylsulfonyl-5N,6O-oxomethylidenenojirimycin (DSO2-ONJ) as selective anti-inflammatory agent by modulation of hemeoxygenase-1 in Bv.2 microglial cells and retinal explants.

Á. Valverde, J. G. García Fernández, C. O. Mellet, 2018, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Monodisperse nanoparticles from self-assembling amphiphilic cyclodextrins: modulable tools for the encapsulation and controlled release of pharmaceuticals.

J. Putaux, J. M. Benito, C. Ortiz Mellet, 2012, Medicinal chemistry (Shariqah (United Arab Emirates)).

Bicyclic Picomolar OGA Inhibitors Enable Chemoproteomic Mapping of Its Endogenous Post-translational Modifications.

L. Foster, G. Davies, M. González-Cuesta, 2022, Journal of the American Chemical Society.

Toward a suitable structural analysis of gene delivery carrier based on polycationic carbohydrates by electron transfer dissociation tandem mass spectrometry.

J. M. Benito, C. Przybylski, J. G. García Fernández, 2016, Analytica chimica acta.

Probing carbohydrate-lectin recognition in heterogeneous environments with monodisperse cyclodextrin-based glycoclusters.

J. L. Jiménez Blanco, J. M. Benito, C. Ortiz Mellet, 2012, The Journal of organic chemistry.

Fullerene-sp2-iminosugar balls as multimodal ligands for lectins and glycosidases: a mechanistic hypothesis for the inhibitory multivalent effect.

C. Ortiz Mellet, J. G. García Fernández, J. Nierengarten, 2013, Chemistry.

Docetaxel-Loaded Nanoparticles Assembled from β-Cyclodextrin/Calixarene Giant Surfactants: Physicochemical Properties and Cytotoxic Effect in Prostate Cancer and Glioblastoma Cells

F. Sansone, C. Ortiz Mellet, J. G. García Fernández, 2017, Front. Pharmacol..

(Pseudo)amide-linked oligosaccharide mimetics: molecular recognition and supramolecular properties

J. L. Jiménez Blanco, C. Ortiz Mellet, J. G. García Fernández, 2010, Beilstein journal of organic chemistry.

Biophysics and protein corona analysis of Janus cyclodextrin-DNA nanocomplexes. Efficient cellular transfection on cancer cells.

G. Caracciolo, J. M. Benito, C. Ortiz Mellet, 2017, Biochimica et biophysica acta. General subjects.

Structure of the Hafnia alvei strain PCM 1188 O-specific polysaccharide.

A. Gamian, J. G. García Fernández, J. Defaye, 1995, Carbohydrate research.

Difructose dianhydrides from sucrose and fructo-oligosaccharides and their use as building blocks for the preparation of amphiphiles, liquid crystals, and polymers.

J. G. García Fernández, J. Defaye, A. Gadelle, 1994, Carbohydrate research.

Selective protonic activation of isomeric glycosylfructoses with pyridinium poly(hydrogen fluoride) and synthesis of spirodioxanyl oligosaccharides.

J. G. García Fernández, J. Defaye, 1992, Carbohydrate research.

Nitrogen starvation induces extensive changes in the redox proteome of Prochlorococcus sp. strain SS120.

M. A. Dominguez-Martin, J. Bárcena, J. G. García Fernández, 2012, Environmental microbiology reports.

Amplified detection of breast cancer autoantibodies using MUC1-based Tn antigen mimics.

S. Nishimura, C. Ortiz Mellet, J. G. García Fernández, 2020, Journal of medicinal chemistry.

Synthesis of N-, S-, and C-glycoside castanospermine analogues with selective neutral alpha-glucosidase inhibitory activity as antitumour agents.

C. Ortiz Mellet, J. G. García Fernández, H. Ouadid‐Ahidouch, 2010, Chemical communications.

Di-D-fructose dianhydride-enriched caramels: effect on colon microbiota, inflammation, and tissue damage in trinitrobenzenesulfonic acid-induced colitic rats.

C. Ortiz Mellet, J. G. García Fernández, A. Zarzuelo, 2010, Journal of agricultural and food chemistry.

Preorganized, macromolecular, gene-delivery systems.

J. M. Benito, C. Ortiz Mellet, J. G. García Fernández, 2010, Chemistry.

Cyclodextrin-Based Functional Glyconanomaterials

J. M. Benito, C. Ortiz Mellet, J. G. García Fernández, 2020, Nanomaterials.

Trehalose-based Janus cyclooligosaccharides: the "Click" synthesis and DNA-directed assembly into pH-sensitive transfectious nanoparticles.

J. L. Jiménez Blanco, T. Carmona, C. Ortiz Mellet, 2016, Chemical communications.

Urea-, thiourea-, and guanidine-linked glycooligomers as phosphate binders in water.

J. L. Jiménez Blanco, J. M. Benito, J. G. García Fernández, 2006, The Journal of organic chemistry.

Tailoring beta-cyclodextrin for DNA complexation and delivery by homogeneous functionalization at the secondary face.

C. Di Giorgio, J. G. García Fernández, C. O. Mellet, 2008, Organic letters.

Probing secondary carbohydrate-protein interactions with highly dense cyclodextrin-centered heteroglycoclusters: the heterocluster effect.

R. Gutiérrez Gallego, J. M. Benito, C. Ortiz Mellet, 2005, Journal of the American Chemical Society.

A general entry to linear, dendritic and branched thiourea-linked glycooligomers as new motifs for phosphate ester recognition in water.

R. Gutiérrez Gallego, J. L. Jiménez Blanco, C. Ortiz Mellet, 2004, Chemical communications.

Multivalent cyclooligosaccharides: versatile carbohydrate clusters with dual role as molecular receptors and lectin ligands.

C. Ortiz Mellet, J. G. García Fernández, J. Defaye, 2002, Chemistry.

Multivalency as an action principle in multimodal lectin recognition and glycosidase inhibition: a paradigm shift driven by carbon-based glyconanomaterials.

C. Ortiz Mellet, J. G. García Fernández, J. Nierengarten, 2017, Journal of materials chemistry. B.

Synthesis and Biophysical Study of Disassembling Nanohybrid Bioconjugates with a Cubic Octasilsesquioxane Core

E. Sundberg, J. G. García Fernández, Alejandro Méndez‐Ardoy, 2012 .

Supramolecular control of oligosaccharide-protein interactions: switchable and tunable ligands for concanavalin A based on beta-cyclodextrin.

J. M. Benito, J. G. García Fernández, V. Moreau, 2006, Angewandte Chemie.

sp2-Iminosugars targeting human lysosomal β-hexosaminidase as pharmacological chaperone candidates for late-onset Tay-Sachs disease

K. Higaki, E. Nanba, M. González-Cuesta, 2022, Journal of enzyme inhibition and medicinal chemistry.

Inhibitor versus chaperone behaviour of d-fagomine, DAB and LAB sp(2)-iminosugar conjugates against glycosidases: A structure-activity relationship study in Gaucher fibroblasts.

K. Higaki, E. Nanba, C. Ortiz Mellet, 2016, European journal of medicinal chemistry.

Conformationally-locked C-glycosides: tuning aglycone interactions for optimal chaperone behaviour in Gaucher fibroblasts.

K. Higaki, E. Nanba, C. Ortiz Mellet, 2016, Organic & biomolecular chemistry.

Conformationally-locked N-glycosides: exploiting long-range non-glycone interactions in the design of pharmacological chaperones for Gaucher disease.

Yoshiyuki Suzuki, K. Higaki, E. Nanba, 2015, European journal of medicinal chemistry.

High-Pressure Nebulization as Application Route for the Peritoneal Administration of siRNA Complexes.

J. M. Benito, J. G. García Fernández, S. D. De Smedt, 2017, Macromolecular bioscience.

A bicyclic 1-deoxygalactonojirimycin derivative as a novel pharmacological chaperone for GM1 gangliosidosis.

Kei Yura, Yasubumi Sakakibara, Katsumi Higaki, 2013, Molecular therapy : the journal of the American Society of Gene Therapy.

Pharmacological Chaperones for the Treatment of α-Mannosidosis.

K. Higaki, E. Nanba, C. Ortiz Mellet, 2019, Journal of medicinal chemistry.

Targeted delivery of pharmacological chaperones for Gaucher disease to macrophages by a mannosylated cyclodextrin carrier.

Yoshiyuki Suzuki, K. Higaki, E. Nanba, 2014, Organic & biomolecular chemistry.

Stereoselective synthesis of 2-acetamido-1,2-dideoxyallonojirimycin (DAJNAc), a new potent hexosaminidase inhibitor.

A. Riera, C. Ortiz Mellet, J. G. García Fernández, 2013, Organic letters.

Synthesis and evaluation of isourea-type glycomimetics related to the indolizidine and trehazolin glycosidase inhibitor families.

C. Ortiz Mellet, J. G. García Fernández, M. I. García-Moreno, 2003, The Journal of organic chemistry.

Tuning glycosidase inhibition through aglycone interactions: pharmacological chaperones for Fabry disease and GM1 gangliosidosis.

Y. Sakakibara, K. Yura, K. Higaki, 2012, Chemical communications.

Generalized anomeric effect in action: synthesis and evaluation of stable reducing indolizidine glycomimetics as glycosidase inhibitors.

F. Cañada, C. Ortiz Mellet, J. G. García Fernández, 2000, The Journal of organic chemistry.

Multivalent glycoligands with lectin/enzyme dual specificity: self-deliverable glycosidase regulators.

K. Higaki, E. Nanba, O. Renaudet, 2019, Chemical communications.

Functional Evaluation of Carbohydrate‐Centred Glycoclusters by Enzyme‐Linked Lectin Assay: Ligands for Concanavalin A

M. Köhn, J. M. Benito, C. Ortiz Mellet, 2004, Chembiochem : a European journal of chemical biology.

Tethered Blatter Radical for Molecular Grafting: Synthesis of 6-Hydroxyhexyloxy, Hydroxymethyl, and Bis(hydroxymethyl) Derivatives and Their Functionalization

J. G. García Fernández, P. Bartos, P. Kaszyński, 2022, Molecules.

Catalyst-Free Synthesis of Alkylpolyglycosides Induced by High-Frequency Ultrasound.

D. Gigmes, C. Ortiz Mellet, J. G. García Fernández, 2018, ChemSusChem.

One-step synthesis of non-anomeric sugar isothiocyanates from sugar azides.

J. M. Benito, C. Ortiz Mellet, J. G. García Fernández, 2002, Carbohydrate research.

Selective Antimicrobial and Antibiofilm Disrupting Properties of Functionalized Diamond Nanoparticles Against Escherichia coli and Staphylococcus aureus

R. Boukherroub, S. Szunerits, L. Mikhalovska, 2015 .

Synthesis of multibranched australine derivatives from reducing castanospermine analogues through the Amadori rearrangement of gem-diamine intermediates: selective inhibitors of β-glucosidase.

E. Álvarez, C. Ortiz Mellet, J. G. García Fernández, 2014, The Journal of organic chemistry.

sp2-Iminosugar glycolipids as inhibitors of lipopolysaccharide-mediated human dendritic cell activation in vitro and of acute inflammation in mice in vivo.

C. Ortiz Mellet, J. G. García Fernández, Jean-Daniel Fauny, 2019, European journal of medicinal chemistry.

Scalable syntheses of both enantiomers of DNJNAc and DGJNAc from glucuronolactone: the effect of N-alkylation on hexosaminidase inhibition.

Andreas F. G. Glawar, T. Butters, C. Ortiz Mellet, 2012, Chemistry.

Glycoligand-targeted core-shell nanospheres with tunable drug release profiles from calixarene-cyclodextrin heterodimers.

F. Sansone, C. Ortiz Mellet, J. G. García Fernández, 2014, Chemical communications.

Inhibition of type 1 fimbriae-mediated Escherichia coli adhesion and biofilm formation by trimeric cluster thiomannosides conjugated to diamond nanoparticles.

Sabine Szunerits, Rabah Boukherroub, R. Boukherroub, 2015, Nanoscale.

Sugar-modified foldamers as conformationally defined and biologically distinct glycopeptide mimics.

R. Woods, Keigo Ito, J. Ghigo, 2013, Angewandte Chemie.

Di-D-fructose dianhydride-enriched products by acid ion-exchange resin-promoted caramelization of D-fructose: chemical analyses.

S. Pilard, C. Ortiz Mellet, J. G. García Fernández, 2010, Journal of agricultural and food chemistry.

Stereoselective Synthesis of Iminosugar 2-Deoxy(thio)glycosides from Bicyclic Iminoglycal Carbamates Promoted by Cerium(IV) Ammonium Nitrate and Cooperative Brønsted Acid-Type Organocatalysis.

C. Ortiz Mellet, J. G. García Fernández, C. Nativi, 2020, The Journal of organic chemistry.

Stereoselective Synthesis of Nojirimycin α-C-Glycosides from a Bicyclic Acyliminium Intermediate: A Convenient Entry to N,C-Biantennary Glycomimetics

M. González-Cuesta, C. Ortiz Mellet, J. G. García Fernández, 2022, ACS omega.

Synthesis of sp2-Iminosugar Selenoglycolipids as Multitarget Drug Candidates with Antiproliferative, Leishmanicidal and Anti-Inflammatory Properties

F. Gamarro, C. Ortiz Mellet, J. G. García Fernández, 2021, Molecules.

Influence of the configurational pattern of sp(2)-iminosugar pseudo N-, S-, O- and C-glycosides on their glycoside inhibitory and antitumor properties.

C. Ortiz Mellet, J. G. García Fernández, J. Padrón, 2016, Carbohydrate research.

o-Xylylene protecting group in carbohydrate chemistry: application to the regioselective protection of a single vic-diol segment in cyclodextrins.

J. L. Jiménez Blanco, C. Ortiz Mellet, J. G. García Fernández, 2013, The Journal of organic chemistry.

sp2-Iminosugar O-, S-, and N-glycosides as conformational mimics of α-linked disaccharides; implications for glycosidase inhibition.

J. Angulo, P. Nieto, C. Ortiz Mellet, 2012, Chemistry.

Intramolecular benzyl protection delivery: a practical synthesis of DMDP and DGDP from D-fructose.

C. Ortiz Mellet, J. G. García Fernández, M. I. García-Moreno, 2006, Organic letters.

Stereoselective synthesis of 2-acetamido-1,2-dideoxynojirimycin (DNJNAc) and ureido-DNJNAc derivatives as new hexosaminidase inhibitors.

A. Riera, C. Ortiz Mellet, J. G. García Fernández, 2015, Organic & biomolecular chemistry.

Synthesis of thiohydantoin-castanospermine glycomimetics as glycosidase inhibitors.

J. G. García Fernández, M. Aguilar-Moncayo, M. I. García-Moreno, 2009, The Journal of organic chemistry.

Synthesis and evaluation of sulfamide-type indolizidines as glycosidase inhibitors.

C. Ortiz Mellet, J. G. García Fernández, Mahmoud Benltifa, 2008, Bioorganic & medicinal chemistry letters.

Influence of the macroring size on the self-association thermodynamics of cyclodextrins with a double-linked naphthalene at the secondary face.

J. M. Benito, C. Ortiz Mellet, F. Mendicuti, 2013, The journal of physical chemistry. B.

Microwave-assisted synthesis of prebiotic di-D-fructose dianhydride-enriched caramels.

Jean-Louis Havet, C. Porte, J. G. García Fernández, 2012, Food chemistry.

Efficient stereoselective synthesis of 2-acetamido-1,2-dideoxyallonojirimycin (DAJNAc) and sp(2)-iminosugar conjugates: Novel hexosaminidase inhibitors with discrimination capabilities between the mature and precursor forms of the enzyme.

K. Higaki, A. Riera, E. Nanba, 2016, European journal of medicinal chemistry.

Cyclodextrin-based multivalent glycodisplays: covalent and supramolecular conjugates to assess carbohydrate-protein interactions.

C. Ortiz Mellet, J. G. García Fernández, Álvaro Martínez, 2013, Chemical Society reviews.

Host-Guest-Mediated DNA Templation of Polycationic Supramolecules for Hierarchical Nanocondensation and the Delivery of Gene Material.

J. M. Benito, T. Carmona, C. Ortiz Mellet, 2015, Chemistry.

Promoting helicity in carbohydrate-containing foldamers through long-range hydrogen bonds.

J. M. Benito, J. G. García Fernández, David Rodríguez-Lucena, 2007, Chemical communications.

Carbohydrate-based receptors with multiple thiourea binding sites. Multipoint hydrogen bond recognition of dicarboxylates and monosaccharides.

J. L. Jiménez Blanco, J. M. Benito, C. Ortiz Mellet, 2001, The Journal of organic chemistry.

Mannose-coated polydiacetylene (PDA)-based nanomicelles: synthesis, interaction with concanavalin A and application in the water solubilization and delivery of hydrophobic molecules.

J. G. García Fernández, M. López-Lázaro, E. Romero-Ben, 2019, Journal of materials chemistry. B.

Tuning of glyconanomaterial shape and size for selective bacterial cell agglutination.

J. G. García Fernández, M. Assali, N. Khiar, 2016, Journal of materials chemistry. B.

Cyclodextrin-based facial amphiphiles: assessing the impact of the hydrophilic-lipophilic balance in the self-assembly, DNA complexation and gene delivery capabilities.

J. M. Benito, C. Di Giorgio, J. G. García Fernández, 2016, Organic & biomolecular chemistry.

Optimizing saccharide-directed molecular delivery to biological receptors: design, synthesis, and biological evaluation of glycodendrimer-cyclodextrin conjugates.

J. M. Benito, C. Ortiz Mellet, J. G. García Fernández, 2004, Journal of the American Chemical Society.

Trehalose- and glucose-derived glycoamphiphiles: small-molecule and nanoparticle Toll-like receptor 4 (TLR4) modulators.

J. L. Jiménez Blanco, C. Ortiz Mellet, J. G. García Fernández, 2014, Journal of medicinal chemistry.

Cyclotrehalins: cyclooligosaccharide receptors featuring a hydrophobic cavity.

J. L. Jiménez Blanco, J. M. Benito, C. Ortiz Mellet, 2002, Angewandte Chemie.

Regioselective sulfonylation at O-2 of cyclomaltoheptaose with 1-(p-tolylsulfonyl)-(1H)-1,2,4-triazole.

J. G. García Fernández, J. Defaye, I. Baussanne, 2003, Carbohydrate research.

Trehalose-based cyclodextrin analogs: cyclotrehalans (CTs)

J. L. Jiménez Blanco, J. M. Benito, C. Ortiz Mellet, 2007 .

Dynamic Control of the Self-Assembling Properties of Cyclodextrins by the Interplay of Aromatic and Host-Guest Interactions

J. M. Benito, T. Carmona, C. Przybylski, 2019, Front. Chem..

Carbohydrate supramolecular chemistry: beyond the multivalent effect.

M. González-Cuesta, C. Ortiz Mellet, J. G. García Fernández, 2020, Chemical communications.

The Impact of Heteromultivalency in Lectin Recognition and Glycosidase Inhibition: An Integrated Mechanistic Study.

C. Ortiz Mellet, J. G. García Fernández, F. Ortega-Caballero, 2017, Chemistry.

Dynamic self-assembly of polycationic clusters based on cyclodextrins for pH-sensitive DNA nanocondensation and delivery by component design.

F. Santoyo-González, J. M. Benito, C. Ortiz Mellet, 2014, Chemistry.

Size-tunable trehalose-based nanocavities: synthesis, structure, and inclusion properties of large-ring cyclotrehalans.

J. M. Benito, C. Ortiz Mellet, J. G. García Fernández, 2009, The Journal of organic chemistry.

Selective radical depolymerization of cellulose to glucose induced by high frequency ultrasound†

J. G. García Fernández, I. Capron, P. N. Amaniampong, 2020, Chemical science.

Protonic and thermal activation of sucrose and the oligosaccharide composition of caramel.

J. G. García Fernández, J. Defaye, 1994, Carbohydrate research.

Protonic reactivity of sucrose in anhydrous hydrogen fluoride.

J. G. García Fernández, J. Defaye, 1994, Carbohydrate research.

Synthesis of dispirodioxanyl pseudo-oligosaccharides by selective protonic activation of isomeric glycosylfructoses in anhydrous hydrogen fluoride.

J. G. García Fernández, J. Defaye, 1994, Carbohydrate research.

Synthesis, conformational analysis and in vivo assays of an anti-cancer vaccine that features an unnatural antigen based on an sp2-iminosugar fragment†

S. Nishimura, J. G. García Fernández, G. Bernardes, 2020, Chemical science.

Qualitative and quantitative evaluation of mono- and disaccharides in D-fructose, D-glucose and sucrose caramels by gas-liquid chromatography-mass spectrometry. Di-D-fructose dianhydrides as tracers of caramel authenticity.

J M García Fernández, A. Voilley, J. G. García Fernández, 1999, Journal of chromatography. A.

Castanospermine-trehazolin hybrids: a new family of glycomimetics with tuneable glycosidase inhibitory properties.

C. Ortiz Mellet, J. G. García Fernández, M. I. García-Moreno, 2002, Chemical communications.

Thiol-ene "Click" Synthesis and Pharmacological Evaluation of C-Glycoside sp2-Iminosugar Glycolipids

F. Gamarro, C. Ortiz Mellet, J. G. García Fernández, 2019, Molecules.

Fluorinated Chaperone-β-Cyclodextrin Formulations for β-Glucocerebrosidase Activity Enhancement in Neuronopathic Gaucher Disease.

K. Higaki, E. Nanba, J. M. Benito, 2017, Journal of medicinal chemistry.

pH-Responsive Pharmacological Chaperones for Rescuing Mutant Glycosidases.

Yoshiyuki Suzuki, K. Higaki, E. Nanba, 2015, Angewandte Chemie.

Cyclodextrin-mediated crystallization of acid β-glucosidase in complex with amphiphilic bicyclic nojirimycin analogues.

J. Sussman, I. Silman, J. M. Benito, 2011, Organic & biomolecular chemistry.

Fluorescent-tagged sp2-iminosugars with potent β-glucosidase inhibitory activity.

T. Wrodnigg, C. Ortiz Mellet, J. G. García Fernández, 2010, Bioorganic & medicinal chemistry.

Glycosidase inhibition by ring-modified castanospermine analogues: tackling enzyme selectivity by inhibitor tailoring.

J. Turkenburg, G. Davies, C. Ortiz Mellet, 2009, Organic & biomolecular chemistry.

6‐Amino‐6‐deoxy‐5,6‐di‐N‐(N′‐octyliminomethylidene)nojirimycin: Synthesis, Biological Evaluation, and Crystal Structure in Complex with Acid β‐Glucosidase

J. Sussman, I. Silman, C. Ortiz Mellet, 2009, Chembiochem : a European journal of chemical biology.

Synthesis and evaluation of calystegine B2 analogues as glycosidase inhibitors.

J. M. Benito, C. Ortiz Mellet, J. G. García Fernández, 2001, The Journal of organic chemistry.

Synthesis of glycosyl(thio)ureido sugars via carbodiimides and their conformational behaviour in water.

C. Ortiz Mellet, J. G. García Fernández, V. M. Díaz Pérez, 2000, Carbohydrate research.

Generalized anomeric effect in gem-diamines: stereoselective synthesis of alpha-N-linked disaccharide mimics.

C. Ortiz Mellet, J. G. García Fernández, M. Aguilar-Moncayo, 2009, Organic letters.

Rational design of cell active C2-modified DGJ analogues for the inhibition of human α-galactosidase A (GALA).

P. Gilormini, M. González-Cuesta, C. Ortiz Mellet, 2021, Organic & biomolecular chemistry.

Anti-Inflammatory (M2) Response Is Induced by a sp2-Iminosugar Glycolipid Sulfoxide in Diabetic Retinopathy

Á. Valverde, A. Campos-Caro, C. Ortiz Mellet, 2021, Frontiers in Immunology.

Construction of giant glycosidase inhibitors from iminosugar-substituted fullerene macromonomers.

C. Ortiz Mellet, J. G. García Fernández, P. Compain, 2017, Journal of materials chemistry. B.

Potent Glycosidase Inhibition with Heterovalent Fullerenes: Unveiling the Binding Modes Triggering Multivalent Inhibition.

C. Ortiz Mellet, J. G. García Fernández, J. Nierengarten, 2016, Chemistry.

Neuronopathic Gaucher's disease: induced pluripotent stem cells for disease modelling and testing chaperone activity of small compounds.

J. I. Izpisúa Belmonte, A. Ribes, C. Ortiz Mellet, 2013, Human molecular genetics.

Molecular Basis for β‐Glucosidase Inhibition by Ring‐Modified Calystegine Analogues

G. Davies, C. Ortiz Mellet, J. G. García Fernández, 2008, Chembiochem : a European journal of chemical biology.

Synthesis and biological evaluation of guanidine-type iminosugars.

J. G. García Fernández, M. I. García-Moreno, Paula Díaz-Pérez, 2008, The Journal of organic chemistry.

Mannobioside biomimetics that trigger DC-SIGN binding selectivity.

P. Nieto, J. Rojo, F. Fieschi, 2022, Chemical Communications.

Synthesis of 6,7-dideoxy-7-isothiocyanatoheptoses: stable fully unprotected monosaccharide isothiocyanates.

J. M. Benito, J. G. García Fernández, C. Oriz Mellet, 1999, Carbohydrate research.

A mild and efficient procedure to remove acetal and dithioacetal protecting groups in carbohydrate derivatives using 2,3-dichloro-5,6-dicyano-1,4-benzoquinone.

C. Ortiz Mellet, J. G. García Fernández, J. Fuentes, 1995, Carbohydrate research.

Multivalency in heterogeneous glycoenvironments: hetero-glycoclusters, -glycopolymers and -glycoassemblies.

J. L. Jiménez Blanco, C. Ortiz Mellet, J. G. García Fernández, 2013, Chemical Society reviews.

Glucosylenamines as glycosyl acceptors: synthesis of gentiobiosylenamines.

J. G. García Fernández, I. Robina, W. Moreda, 1992, Carbohydrate research.

Multimeric Lactoside “Click Clusters” as Tools to Investigate the Effect of Linker Length in Specific Interactions with Peanut Lectin, Galectin‐1, and ‐3

J. G. García Fernández, J. Kovensky, F. Dupradeau, 2010, Chembiochem : a European journal of chemical biology.

Synthesis of β-galactosylamides as ligands of the peanut lectin. Insights into the recognition process.

J. G. García Fernández, J. Kovensky, M. E. Cano, 2017, Carbohydrate research.

Novel Therapies for Orphan Diseases.

C. Ortiz Mellet, J. G. García Fernández, 2019, ACS medicinal chemistry letters.

Tuning the Topological Landscape of DNA-Cyclodextrin Nanocomplexes by Molecular Design.

Ana I. Carbajo‐Gordillo, J. M. Benito, C. Ortiz Mellet, 2020, Chemistry.

Rigid spacer-mediated synthesis of bis-spiroketal ring systems: stereoselective synthesis of nonsymmetrical spiro disaccharides.

J. G. García Fernández, P. Balbuena, M. I. García-Moreno, 2005, Organic letters.

Difructose dianhydrides (DFAs) and DFA-enriched products as functional foods.

J. G. García Fernández, C. Mellet, 2010, Topics in current chemistry.

Carbohydrate-derived spiroketals: stereoselective synthesis of di-D-fructose dianhydrides via intramolecular aglycon delivery.

C. Ortiz Mellet, J. G. García Fernández, E. Rubio, 2003, Organic letters.

Carbohydrate-derived spiroketals. Stereoselective synthesis of di-D-fructose dianhydrides by boron trifluoride promoted glycosylation-spiroketalization of acetal precursors.

J. M. Benito, C. Ortiz Mellet, J. G. García Fernández, 2001, Organic letters.

Cyclodextrin-Based Nanostructure Efficiently Delivers siRNA to Glioblastoma Cells Preferentially via Macropinocytosis

J. L. Jiménez Blanco, C. Ortiz Mellet, J. G. García Fernández, 2020, International journal of molecular sciences.

Synthesis, self-assembly and anticancer drug encapsulation and delivery properties of cyclodextrin-based giant amphiphiles.

F. Sansone, J. G. García Fernández, Laura Gallego-Yerga, 2021, Carbohydrate polymers.

Adsorption of difructose dianhydrides on hydrophobic Y-zeolites

J. G. García Fernández, C. Buttersack, Marta Gómez García, 2020 .

Probing the nature of the cluster effect observed with synthetic multivalent galactosides and peanut agglutinin lectin.

C. Ortiz Mellet, J. G. García Fernández, Laura Gallego-Yerga, 2013, Chemistry.

Structure and serological analysis of the Hafnia alvei 481-L O-specific polysaccharide containing phosphate in the backbone chain.

A. Gamian, E. Vinogradov, J. G. García Fernández, 2006, Carbohydrate research.

Fluoro-labelled sp2-iminoglycolipids with immunomodulatory properties.

J. G. García Fernández, J. Padrón, E. Sánchez-Fernández, 2023, European journal of medicinal chemistry.

Improved Magneto-Microfluidic Separation of Nanoparticles through Formation of the β-Cyclodextrin-Curcumin Inclusion Complex.

P. Kuzhir, J. G. García Fernández, G. Godeau, 2021, Langmuir : the ACS journal of surfaces and colloids.

Trehalose-based Siamese twin amphiphiles with tunable self-assembling, DNA nanocomplexing and gene delivery properties.

Ana I. Carbajo‐Gordillo, J. L. Jiménez Blanco, J. M. Benito, 2019, Chemical communications.

Targeted gene delivery by new folate-polycationic amphiphilic cyclodextrin-DNA nanocomplexes in vitro and in vivo.

C. Ortiz Mellet, J. G. García Fernández, Koldo Urbiola, 2013, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Modulation of microglia polarization dynamics during diabetic retinopathy in db/db mice.

Á. Valverde, R. Simó, C. Hernández, 2016, Biochimica et biophysica acta.

The o-xylylene protecting group as an element of conformational control of remote stereochemistry in the synthesis of spiroketals.

C. Ortiz Mellet, J. G. García Fernández, P. Balbuena, 2006, Chemical communications.

Early detection of learning difficulties using the BADyG-E2r Battery during primary education

J. G. García Fernández, Ignasi Navarro Soria, Cándido J. Inglés Saura, 2020, Psicologia, reflexao e critica : revista semestral do Departamento de Psicologia da UFRGS.

Amphiphilic oligoethyleneimine-β-cyclodextrin "click" clusters for enhanced DNA delivery.

J. L. Jiménez Blanco, C. Di Giorgio, J. G. García Fernández, 2013, The Journal of organic chemistry.

Rational design of cationic cyclooligosaccharides as efficient gene delivery systems.

Alejandro Díaz-Moscoso, A. Mazzaglia, N. Micali, 2008, Chemical communications.

Impact of Nonthermal Atmospheric Plasma on the Structure of Cellulose: Access to Soluble Branched Glucans.

François Jérôme, Abdellatif Barakat, Cédric Gaillard, 2016, Chemistry.

Synthesis of high-mannose oligosaccharide analogues through click chemistry: true functional mimics of their natural counterparts against lectins?

C. Ortiz Mellet, J. G. García Fernández, Alejandro Méndez‐Ardoy, 2015, Chemistry.

Plasmid-Templated Control of DNA-Cyclodextrin Nanoparticle Morphology through Molecular Vector Design for Effective Gene Delivery.

J. M. Benito, C. Ortiz Mellet, C. Tros de Ilarduya, 2018, Chemistry.

Correction to "Generalized Anomeric Effect in gem-Diamines: Stereoselective Synthesis of α-N-Linked Disaccharide Mimics".

C. Ortiz Mellet, J. G. García Fernández, M. Aguilar-Moncayo, 2016, Organic Letters.

Molecular basis of 1-deoxygalactonojirimycin arylthiourea binding to human α-galactosidase a: pharmacological chaperoning efficacy on Fabry disease mutants.

Yoshiyuki Suzuki, K. Higaki, E. Nanba, 2014, ACS chemical biology.

Bicyclic Derivatives of L‐Idonojirimycin as Pharmacological Chaperones for Neuronopathic Forms of Gaucher Disease

F. Sánchez-Jiménez, C. Ortiz Mellet, J. G. García Fernández, 2013, Chembiochem : a European journal of chemical biology.

Pseudoamide-type pyrrolidine and pyrrolizidine glycomimetics and their inhibitory activities against glycosidases.

J. G. García Fernández, M. I. García-Moreno, David Rodríguez-Lucena, 2004, The Journal of organic chemistry.

Serine-/Cysteine-Based sp2-Iminoglycolipids as Novel TLR4 Agonists: Evaluation of Their Adjuvancy and Immunotherapeutic Properties in a Murine Model of Asthma.

M. González-Cuesta, C. Ortiz Mellet, J. G. García Fernández, 2023, Journal of medicinal chemistry.

Cyclodextrin-scaffolded glycotransporters for gene delivery

J. M. Benito, C. Ortiz Mellet, J. G. García Fernández, 2013 .

Mechanocatalytic Depolymerization of Cellulose With Perfluorinated Sulfonic Acid Ionomers

C. Oldani, J. G. García Fernández, F. Jérôme, 2018, Front. Chem..

Synthesis and Comparative Glycosidase Inhibitory Properties of Reducing Castanospermine Analogues

C. Ortiz Mellet, J. G. García Fernández, M. I. García-Moreno, 2005 .

Click Synthesis of Size- and Shape-Tunable Star Polymers with Functional Macrocyclic Cores for Synergistic DNA Complexation and Delivery.

Ana I. Carbajo‐Gordillo, J. L. Jiménez Blanco, J. M. Benito, 2020, Biomacromolecules.

Reversible Light-Induced Dimerization of Secondary Face Azobenzene-Functionalized β-Cyclodextrin Derivatives

J. M. Benito, C. Ortiz Mellet, F. Mendicuti, 2023, The Journal of organic chemistry.

Synthesis and glycosidase inhibitory activity of isourea-type bicyclic sp2-iminosugars related to galactonojirimycin and allonojirimycin

C. Ortiz Mellet, J. G. García Fernández, C. O. Mellet, 2012 .

sp2-Iminosugars as chemical mimics for glycodrug design

J. G. García Fernández, C. O. Mellet, J. M. Fernandez, 2020 .

Microwave-assisted synthesis of prebiotic di-D-fructose dianhydride-enriched caramels.

Jean-Louis Havet, C. Porte, J. G. García Fernández, 2012, Food chemistry.

Catalyst-Free Synthesis of Alkylpolyglycosides Induced by High-Frequency Ultrasound.

D. Gigmes, C. Ortiz Mellet, J. G. García Fernández, 2018, ChemSusChem.

Inhibition of type 1 fimbriae-mediated Escherichia coli adhesion and biofilm formation by trimeric cluster thiomannosides conjugated to diamond nanoparticles.

R. Boukherroub, S. Szunerits, J. Ghigo, 2015, Nanoscale.

Conformationally-locked N-glycosides with selective β-glucosidase inhibitory activity: identification of a new non-iminosugar-type pharmacological chaperone for Gaucher disease.

Yoshiyuki Suzuki, K. Higaki, E. Nanba, 2012, Journal of medicinal chemistry.

Oligosaccharide tagged β-cyclodextrins: synthesis and biological affinity towards Concanavalin A

J. G. García Fernández, V. Moreau, F. Djedaïni-Pilard, 2007 .

Multimeric Lactoside “Click Clusters” as Tools to Investigate the Effect of Linker Length in Specific Interactions with Peanut Lectin, Galectin‐1, and ‐3

J. G. García Fernández, J. Kovensky, F. Dupradeau, 2010, Chembiochem : a European journal of chemical biology.

Influence of the macroring size on the self-association thermodynamics of cyclodextrins with a double-linked naphthalene at the secondary face.

J. M. Benito, C. Ortiz Mellet, F. Mendicuti, 2013, The journal of physical chemistry. B.