I. Kerr

发表

Application of fluorescence correlation spectroscopy to study substrate binding in styrene maleic acid lipid copolymer encapsulated ABCG2

Aaron J. Horsey, D. Briggs, N. Holliday, 2020, Biochimica et biophysica acta. Biomembranes.

Disruption of the Unique ABCG-Family NBD:NBD Interface Impacts Both Drug Transport and ATP Hydrolysis

D. Briggs, I. Kerr, P. Kapoor, 2020, International journal of molecular sciences.

Dimerization of ABCG2 Analysed by Bimolecular Fluorescence Complementation

D. Briggs, N. Holliday, I. Kerr, 2011, PloS one.

Heterologous Expression of a Membrane-Spanning Auxin Importer: Implications for Functional Analyses of Auxin Transporters

M. Bennett, I. Kerr, Ameena J. Haider, 2009, International journal of plant genomics.

Transbilayer pores formed by beta-barrels: molecular modeling of pore structures and properties.

M. Sansom, M. Sansom, I. Kerr, 1995, Biophysical journal.

Polymorphisms of the Multidrug Pump ABCG2: A Systematic Review of Their Effect on Protein Expression, Function, and Drug Pharmacokinetics

I. Kerr, P. Kapoor, N. Heyes, 2018, Drug Metabolism and Disposition.

8.8 Molecular Aspects of the Translocation Process by ABC Proteins

A. M. George, R. Callaghan, I. Kerr, 2012 .

The ABC Transporters: Structural Insights into Drug Transport

R. Callaghan, I. Kerr, R. Ford, 2009 .

Location of contact residues in pharmacologically distinct drug binding sites on P‐glycoprotein

A. M. George, R. Callaghan, I. Kerr, 2017, Biochemical pharmacology.

The auxin influx carrier LAX3 promotes lateral root emergence

Tom Beeckman, Ive De Smet, Kanu Patel, 2008, Nature Cell Biology.

The influenza A virus M2 channel: a molecular modeling and simulation study.

G. R. Smith, G R Smith, M. Sansom, 1997, Virology.

Influenza virus M2 protein: a molecular modelling study of the ion channel.

M. Sansom, I. Kerr, 1993, Protein engineering.

Hormone Transport

I. Kerr, D. Carrier, J. Twycross, 2008 .

Induction of a stress response in Lactococcus lactis is associated with a resistance to ribosomally active antibiotics

M. Ridley, R. Layfield, D. Briggs, 2011, The FEBS journal.

Single Molecule or Ensemble Fluorescence Microscopy Investigations of ABC Transporter Oligomerisation and Dynamics

N. Holliday, I. Kerr, Kelvin Wong, 2016 .

Long-term exposure to irinotecan reduces cell migration in glioma cells

D. Hussein, B. Coyle, I. Kerr, 2016, Journal of Neuro-Oncology.

Overcoming ABCG 2 ‐ mediated drug resistance with imidazo ‐ [ 1 , 2 ‐ b ] ‐ pyridazine ‐ based Pim 1 kinase inhibitors

S. Knapp, R. Callaghan, I. Kerr, 2019 .

Overcoming ABCG2-mediated drug resistance with imidazo-[1,2-b]-pyridazine-based Pim1 kinase inhibitors

S. Knapp, R. Callaghan, I. Kerr, 2015, Cancer Chemotherapy and Pharmacology.

Cellular Patterning of Arabidopsis Roots Under Low Phosphate Conditions

A. French, I. Kerr, L. Band, 2018, Front. Plant Sci..

Multiple drugbinding sites on the R482G isoform of the ABCG2 transporter

R. Callaghan, I. Kerr, R. Clark, 2006, British journal of pharmacology.

Mammalian ABCG-transporters, sterols and lipids: To bind perchance to transport ?

I. Gelissen, I. Kerr, Ella Hutchison, 2020, Biochimica et biophysica acta. Molecular and cell biology of lipids.

Vinca alkaloid binding to P-glycoprotein occurs in a processive manner.

R. Callaghan, D. Briggs, I. Kerr, 2022, Biochimica et biophysica acta. Biomembranes.

Improving the stability and function of purified ABCB1 and ABCA4: the influence of membrane lipids.

S. Prince, R. Callaghan, I. Kerr, 2014, Biochimica et biophysica acta.

BCRP-Breast Cancer Resistance Protein

I. Kerr, 2008 .

Sequence analysis of twin ATP binding cassette proteins involved in translational control, antibiotic resistance, and ribonuclease L inhibition.

I. Kerr, 2004, Biochemical and biophysical research communications.

Is ATP binding responsible for initiating drug translocation by the multidrug transporter ABCG2?

R. Callaghan, I. Kerr, C. McDevitt, 2008, The FEBS journal.

Structure-Function Analysis of the Presumptive Arabidopsis Auxin Permease AUX1 W

S. May, P. Millner, L. Williams, 2004 .

Alamethicin pyromellitate: an ion-activated channel-forming peptide.

B. Wallace, R. Epand, M. Sansom, 1994, Biochemistry.

The function of the pseudo phosphotransfer proteins has diverged between rice and Arabidopsis.

K. Ljung, J. Kieber, Dawei Xu, 2021, The Plant journal : for cell and molecular biology.

Intrinsic acyl-CoA thioesterase activity of a peroxisomal ATP binding cassette transporter is required for transport and metabolism of fatty acids

S. Baldwin, R. Wanders, F. Theodoulou, 2013, Proceedings of the National Academy of Sciences.

Analysis of the Sam50 translocase of Excavate organisms supports evolution of divergent organelles from a common endosymbiotic event

I. Kerr, K. Lawler, C. Kay, 2013, Bioscience reports.

ABCG subfamily (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

I. Kerr, 2019, IUPHAR/BPS Guide to Pharmacology CITE.

The Topography of Transmembrane Segment Six Is Altered during the Catalytic Cycle of P-glycoprotein*

K. Linton, R. Callaghan, I. Kerr, 2004, Journal of Biological Chemistry.

The translocation mechanism of P‐glycoprotein

R. Callaghan, I. Kerr, R. Ford, 2006, FEBS letters.

Packing interactions of aib‐containing helices: Molecular modeling of parallel dimers of simple hydrophobic helices and of alamethicin

J. Breed, M. Sansom, I. Kerr, 1995, Biopolymers.

Unraveling the Evolution of Auxin Signaling1[C][W]

Michael H. Wilson, G. Jürgens, R. Timme, 2010, Plant Physiology.

Y-Box Binding Protein-1: A Neglected Target in Pediatric Brain Tumors?

B. Coyle, I. Kerr, L. Taylor, 2020, Molecular Cancer Research.

High-Grade Gliomas

C. Q. Lee, David T. W. Jones, Michael D. Brooks, 2012, Oxford Medicine Online.

Pediatric brain tumor cancer stem cells: cell cycle dynamics, DNA repair, and etoposide extrusion

J. Lowe, D. Hussein, R. Grundy, 2010, Neuro-oncology.

ABC transporter research: going strong 40 years on

F. Theodoulou, I. Kerr, 2015, Biochemical Society transactions.

A selective biotinylated probe for V1a vasopressin receptors

J. Howl, I. Kerr, M. Wheatley, 1991, Molecular and Cellular Endocrinology.

Novel vasopressin receptor ligands.

J. Howl, I. Kerr, M. Wheatley, 1991, Biochemical Society transactions.

Identifying new biomarkers of aggressive Group 3 and SHH medulloblastoma using 3D hydrogel models, single cell RNA sequencing and 3D OrbiSIMS imaging

M. Alexander, A. Lourdusamy, D. Scurr, 2023, Acta Neuropathologica Communications.

Ion channels formed by HIV‐1 Vpu: a modelling and simulation study

M. Sansom, I. Kerr, A.L Grice, 1997, FEBS Letters.

ABCB1 inhibition provides a novel therapeutic target to block TWIST1-induced migration in medulloblastoma

S. Pfister, A. Korshunov, A. Lourdusamy, 2021, Neuro-oncology advances.

A role for ABCB1 in prognosis, invasion and drug resistance in ependymoma

Jo-Fen Liu, J. Kilday, R. Grundy, 2019, Scientific Reports.

Structure and association of ATP-binding cassette transporter nucleotide-binding domains.

I. Kerr, 2002, Biochimica et biophysica acta.

3D hydrogels reveal medulloblastoma subgroup differences and identify extracellular matrix subtypes that predict patient outcome

A. Lourdusamy, B. Coyle, I. Kerr, 2020, The Journal of pathology.

Parallel helix bundles and ion channels: molecular modeling via simulated annealing and restrained molecular dynamics.

M. Sansom, I. Kerr, O. Smart, 1994, Biophysical journal.

Annexins in human breast cancer: Possible predictors of pathological response to neoadjuvant chemotherapy.

R. Layfield, I. Kerr, O. Eremin, 2009, European journal of cancer.

Residues contributing to drug transport by ABCG2 are localised to multiple drug-binding pockets

D. Briggs, I. Kerr, P. Kapoor, 2018, The Biochemical journal.

Purification and structural analyses of ABCG2.

R. Callaghan, I. Kerr, C. McDevitt, 2009, Advanced drug delivery reviews.

Purification and 3D structural analysis of oligomeric human multidrug transporter ABCG2.

R. Callaghan, I. Kerr, C. McDevitt, 2006, Structure.

Picky ABCG5/G8 and promiscuous ABCG2 ‐ a tale of fatty diets and drug toxicity

K. Kuchler, T. Stockner, I. Kerr, 2020, FEBS letters.

Detergent free purification of ABC transporters

Mohammed Jamshad, I. Kerr, T. Knowles, 2015 .

Detergent-free purification of ABC (ATP-binding-cassette) transporters.

Mohammed Jamshad, I. Kerr, T. Knowles, 2014, The Biochemical journal.

Towards understanding promiscuity in multidrug efflux pumps.

P. Biggin, I. Kerr, A. Rothnie, 2014, Trends in biochemical sciences.

Identification of residues in ABCG2 affecting protein trafficking and drug transport, using co-evolutionary analysis of ABCG sequences

D. Briggs, I. Kerr, Megan H. Cox, 2015, Bioscience reports.

The multidrug transporter ABCG2: still more questions than answers

Aaron J. Horsey, I. Kerr, Megan H. Cox, 2016, Biochemical Society transactions.

Structure-based interpretation of the mutagenesis database for the nucleotide binding domains of P-glycoprotein.

I. Kerr, M. O’Mara, I D Kerr, 2008, Biochimica et biophysica acta.

Cross-linking, DEER-spectroscopy and molecular dynamics confirm the inward facing state of P-glycoprotein in a lipid membrane.

R. Callaghan, D. Briggs, I. Kerr, 2020, Journal of structural biology.

Transmembrane helix 12 modulates progression of the ATP catalytic cycle in ABCB1.

D. Tieleman, R. Callaghan, I. Kerr, 2009, Biochemistry.

Review/Drug Metabolism and Transport: P-glycoprotein: So Many Ways to Turn It On

R. Callaghan, I. Kerr, S. Potter, 2008 .

Cytosolic region of TM6 in P-glycoprotein: topographical analysis and functional perturbation by site directed labeling.

D. Tieleman, R. Callaghan, I. Kerr, 2008, Biochemistry.

An atomic detail model for the human ATP binding cassette transporter P‐glycoprotein derived from disulphide cross‐ linking and homology modeling

K. Linton, C. Higgins, M. Sansom, 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Analysis of Sequence Divergence in Mammalian ABCGs Predicts a Structural Network of Residues That Underlies Functional Divergence

T. Stockner, N. Holliday, S. Briddon, 2021, International journal of molecular sciences.

Multidrug efflux pumps: The structures of prokaryotic ATP‐binding cassette transporter efflux pumps and implications for our understanding of eukaryotic P‐glycoproteins and homologues

A. M. George, Peter M. S. Jones, I. Kerr, 2010, The FEBS journal.

Drug Resistance in Medulloblastoma Is Driven by YB-1, ABCB1 and a Seven-Gene Drug Signature

Gianpiero di Leva, B. Coyle, I. Kerr, 2023, Cancers.

The central cavity of ABCB1 undergoes alternating access during ATP hydrolysis

R. Callaghan, I. Kerr, C. McDevitt, 2014, The FEBS journal.

Overcoming multiple drug resistance mechanisms in medulloblastoma

S. Pfister, A. Korshunov, T. Bradshaw, 2014, Acta neuropathologica communications.

Repacking of the transmembrane domains of P‐glycoprotein during the transport ATPase cycle

K. Linton, C. Higgins, R. Callaghan, 2001, The EMBO journal.

Seven-helix bundles: molecular modeling via restrained molecular dynamics.

M. Sansom, J. Breed, I. Kerr, 1995, Biophysical journal.

Principles of membrane protein structure

M. Sansom, I. Kerr, 1995 .

The Binding of Auxin to the Arabidopsis Auxin Influx Transporter AUX11[OA]

M. Bennett, R. Callaghan, I. Kerr, 2008, Plant Physiology.

Principles of proteomics and its applications in cancer.

R. Layfield, I. Kerr, O. Eremin, 2007, The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland.

The ABCG family of membrane‐associated transporters: you don't have to be big to be mighty

I. Gelissen, I. Kerr, Ameena J. Haider, 2011, British journal of pharmacology.

Simulation studies on bacteriorhodopsin bundle of transmembrane α segments

M. Sansom, I. Kerr, H. Son, 2000, European Biophysics Journal.

The voltage-gated potassium channel: Sequence analysis and molecular modelling of the pore domain

M. Sansom, I. Kerr, K. M. Ranatunga, 1999 .

Molecular dynamics simulations of isolated transmembrane helices of potassium channels.

M. Sansom, I. Kerr, H. Son, 1998, Biopolymers.

New insight into the biochemical mechanisms regulating auxin transport in plants.

M. Bennett, I. Kerr, M. Bennett, 2007, The Biochemical journal.

Ion channels formed by amphipathic helical peptides

M. Sansom, I. Kerr, I. Mellor, 1991, European Biophysics Journal.

Localisation of a family of complex‐forming β‐barrels in the T. vaginalis hydrogenosomal membrane

I. Kerr, K. Lawler, S. Dyall, 2012, FEBS letters.

Water in channel-like cavities: structure and dynamics.

M. Sansom, J. Breed, I. Kerr, 1996, Biophysical journal.

Modelling membrane proteins using structural restraints

M. Sansom, I. Kerr, R. Sankararamakrishnan, 1995, Nature Structural Biology.

ABCG2: does resolving its structure elucidate the mechanism?

Aaron J. Horsey, I. Kerr, P. Kapoor, 2018, Biochemical Society transactions.

Transmembrane helix 12 plays a pivotal role in coupling energy provision and drug binding in ABCB1

R. Callaghan, I. Kerr, M. O’Mara, 2010, The FEBS journal.

Structure-Function Analysis of the Presumptive Arabidopsis Auxin Permease AUX 1

Alan Marchant, Richard Napier, Sean May, 2004 .

Proteomic profiling of MCF-7 breast cancer cells with chemoresistance to different types of anti-cancer drugs.

R. Layfield, I. Kerr, O. Eremin, 2007, International journal of oncology.

Structure-Function Analysis of the Presumptive Arabidopsis Auxin Permease AUX1w⃞

Alan Marchant, Richard Napier, Sean May, 2004, The Plant Cell Online.

ABCG subfamily in GtoPdb v.2023.1

I. Kerr, 2023, IUPHAR/BPS Guide to Pharmacology CITE.

Plasma membrane dynamics and tetrameric organisation of ABCG2 transporters in mammalian cells revealed by single particle imaging techniques.

N. Holliday, S. Briddon, I. Kerr, 2016, Biochimica et biophysica acta.

Extracellular Vesicles Potentiate Medulloblastoma Metastasis in an EMMPRIN and MMP-2 Dependent Manner

B. Coyle, I. Kerr, F. Linke, 2023, Cancers.

Cation selectivity in ion channels

M. Sansom, I. Kerr, 1995, Nature.

CHAPTER 4 – STRUCTURE OF ABC TRANSPORTERS

K. Linton, C. Higgins, I. Kerr, 2003 .

Nucleotide-dependent conformational changes in HisP: molecular dynamics simulations of an ABC transporter nucleotide-binding domain.

F. Ashcroft, M. Sansom, I. Kerr, 2004, Biophysical Journal.

Molecular dynamics simulations of water within models of ion channels.

M S Sansom, J. Breed, M. Sansom, 1996, Biophysical journal.

ABC proteins and antibiotic drug resistance: is it all about transport?

J. Cove, I. Kerr, E. Reynolds, 2005, Biochemical Society transactions.

Modelling the restoration of wild-type dynamic behaviour in DeltaF508-CFTR NBD1 by 8-cyclopentyl-1,3-dipropylxanthine.

Daniel J. Warner, C. Laughton, I. Kerr, 2007, Journal of molecular graphics & modelling.

A role for ABCB1 in prognosis, invasion and drug resistance in ependymoma

Jo-Fen Liu, J. Kilday, R. Grundy, 2019, Scientific Reports.

ABCB1 in children's brain tumours.

Beth Coyle, Maya Kessler, B. Coyle, 2015, Biochemical Society transactions.

BLBP Is Both a Marker for Poor Prognosis and a Potential Therapeutic Target in Paediatric Ependymoma

Jo-Fen Liu, R. Grundy, B. Coyle, 2021, Cancers.

In Vitro Fluorescence Resonance Energy Transfer-Based Assay Used to Determine the Rab27-Effector-Binding Affinity.

I. Kerr, Alistair N. Hume, Raghdan Z. Al-Saad, 2020, Assay and drug development technologies.

Ion channel formation by synthetic analogues of staphylococcal delta-toxin.

J. Rice, D. Fredkin, M. Sansom, 1995, Biochimica et biophysica acta.

Hydrophilic surface maps of channel-forming peptides: analysis of amphipathic helices

M. Sansom, I. Kerr, 2004, European Biophysics Journal.

Communication between the nucleotide binding domains of P-glycoprotein occurs via conformational changes that involve residue 508.

K. Linton, R. Callaghan, I. Kerr, 2003, Biochemistry.

The alpha-5 segment of Bacillus thuringiensis delta-endotoxin: in vitro activity, ion channel formation and molecular modelling.

Y. Shai, M. Sansom, E. Gazit, 1994, The Biochemical journal.

Residue G346 in transmembrane segment six is involved in inter-domain communication in P-glycoprotein.

D. Tieleman, R. Callaghan, I. Kerr, 2007, Biochemistry.

The coupling mechanism of P‐glycoprotein involves residue L339 in the sixth membrane spanning segment

R. Callaghan, I. Kerr, A. Rothnie, 2005, FEBS letters.

Studies of the pore-forming domain of a voltage-gated potassium channel protein.

M. Sansom, P. Haris, I. Kerr, 1994, Protein engineering.

A novel family of phospholipase D homologues that includes phospholipid synthases and putative endonucleases: Identification of duplicated repeats and potential active site residues

C P Ponting, C. Ponting, I. Kerr, 1996, Protein science : a publication of the Protein Society.

High grade gliomas

C. Q. Lee, David T. W. Jones, Michael D. Brooks, 2022, Progress in Brain Research.

The ATP-Binding Cassette Proteins of the Deep-Branching Protozoan Parasite Trichomonas vaginalis

I. Kerr, T. Self, K. Lawler, 2012, PLoS neglected tropical diseases.

Hormone Transport

I. Kerr, D. Carrier, J. Twycross, 2022 .

Definition of the domain boundaries is critical to the expression of the nucleotide-binding domains of P-glycoprotein

K. Linton, C. Higgins, R. Callaghan, 2003, European Biophysics Journal.

MBRS-21. EXTRACELLULAR VESICLES FROM METASTATIC MEDULLOBLASTOMA CELL LINES CARRY mRNAs KNOWN TO CORRELATE WITH METASTATIC DISEASE

B. Coyle, I. Kerr, F. Linke, 2018, Neuro-Oncology.

Alamethicin channels - modelling via restrained molecular dynamics simulations.

P. Biggin, J. Breed, M. Sansom, 1997, Biochimica et biophysica acta.

Molecular modelling of Staphylococcal δ-toxin ion channels by restrained molecular dynamics

J. Breed, M. Sansom, I. Kerr, 1996 .

Ion channel stability and hydrogen bonding. Molecular modelling of channels formed by synthetic alamethicin analogues.

J. Breed, M. Sansom, I. Kerr, 1997, Biochimica et biophysica acta.

The central cavity of ABCB1 undergoes alternating access during ATP hydrolysis

R. Callaghan, I. Kerr, C. McDevitt, 2014, The FEBS journal.

The multidrug transporter ABCG 2 : still more questions than answers

Aaron J. Horsey, I. Kerr, Megan H. Cox, 2016 .