Y. Hamashima

发表

Rigorous control of vesicle‐forming lipid pKa by fluorine‐conjugated bioisosteres for gene‐silencing with siRNA

N. Oku, Ayaka Okamoto, Hiroyuki Koide, 2019, Journal of controlled release : official journal of the Controlled Release Society.

Practical synthesis of kainoids: a new chemical probe precursor and a fluorescent probe.

R. Sakai, Y. Hamashima, T. Asakawa, 2014, Organic letters.

Regio- and chemoselective Csp3–H arylation of benzylamines by single electron transfer/hydrogen atom transfer synergistic catalysis† †Electronic supplementary information (ESI) available: Experimental procedure, CV data, characterization data of products. See DOI: 10.1039/c8sc02965b

Yuji Kawato, H. Egami, Y. Hamashima, 2018, Chemical science.

Engineering of Lipid Nanoparticles by the Multifunctionalization of the Surface with Amino Acid Derivatives for the Neutralization of a Target Toxic Peptide

Kazuhiro Saito, N. Oku, Hiroyuki Koide, 2020, Advanced Functional Materials.

Sequestering and inhibiting a vascular endothelial growth factor in vivo by systemic administration of a synthetic polymer nanoparticle

Y. Miura, Y. Hoshino, N. Oku, 2019, Journal of controlled release : official journal of the Controlled Release Society.

Development of Catalytic Enantioselective Reactions via Palladium Enolates as Key Intermediates

M. Sodeoka, Y. Hamashima, 2005 .

Immobilization and reuse of Pd complexes in ionic liquid: efficient catalytic asymmetric fluorination and Michael reactions with beta-ketoesters.

M. Sodeoka, Y. Hamashima, H. Takano, 2003, Organic letters.

Acid-base catalysis of chiral Pd complexes: development of novel catalytic asymmetric reactions and their application to synthesis of drug candidates.

Y. Hamashima, 2006, Chemical & pharmaceutical bulletin.

Development of catalytic asymmetric reactions via chiral palladium enolates.

M. Sodeoka, Y. Hamashima, 2004, Chemical record.

Diastereo- and enantioselective conjugate addition of alpha-ketoesters to nitroalkenes catalyzed by a chiral Ni(OAc)(2) complex under mild conditions.

M. Sodeoka, D. Hashizume, Y. Hamashima, 2010, Journal of the American Chemical Society.

Design of synthetic polymer nanoparticles that inhibit glucose absorption from the intestine.

Y. Hoshino, N. Oku, Hiroyuki Koide, 2021, Biochemical and biophysical research communications.

Oxidative and Redox‐Neutral Approaches to Symmetrical Diamines and Diols by Single Electron Transfer/Hydrogen Atom Transfer Synergistic Catalysis

H. Egami, Y. Hamashima, Takafumi Ide, 2020 .

Benzylic C-H Trifluoromethylation via Photoenol.

Yuji Kawato, H. Egami, Y. Hamashima, 2017, Organic letters.

Dual catalysis with copper and rhenium for trifluoromethylation of propargylic alcohols: efficient synthesis of α-trifluoromethylated enones.

M. Sodeoka, H. Egami, Y. Hamashima, 2014, Chemistry.

Copper-catalyzed trifluoromethylation of allylsilanes.

M. Sodeoka, H. Egami, Y. Hamashima, 2012, Angewandte Chemie.

Structure Dependence in Asymmetric Deprotonative Fluorination and Fluorocyclization Reactions of Allylamine Derivatives with Linked Binaphthyl Dicarboxylate Phase-Transfer Catalyst.

H. Egami, Y. Hamashima, Tomoki Niwa, 2021, Journal of the American Chemical Society.

Dearomative enantio- and diastereoselective difluorination of resorcinol derivatives

H. Egami, Y. Hamashima, Minami Otsubo, 2021 .

Asymmetric Dearomative Fluorination of 2-Naphthols with Dicarboxylate Phase-Transfer Catalyst.

H. Egami, Y. Hamashima, Tomoki Niwa, 2020, Angewandte Chemie.

Asymmetric Dearomatizing Fluoroamidation of Indole Derivatives with Dianionic Phase-Transfer Catalyst.

H. Egami, Y. Hamashima, Minami Otsubo, 2020, Organic letters.

Asymmetric Dearomative Fluorination of 2‐Naphthols with a Dicarboxylate Phase‐Transfer Catalyst

H. Egami, Y. Hamashima, Tomoki Niwa, 2020, Angewandte Chemie.

Asymmetric Fluorolactonization with a Bifunctional Hydroxyl Carboxylate Catalyst.

D. Hashizume, Yuji Kawato, H. Egami, 2015, Journal of the American Chemical Society.

Catalytic asymmetric mono-fluorination of α-keto esters: synthesis of optically active β-fluoro-α-hydroxy and β-fluoro-α-amino acid derivatives.

M. Sodeoka, Y. Hamashima, Y. Kitamura, 2012, Angewandte Chemie.

Direct C2-trifluoromethylation of indole derivatives catalyzed by copper acetate

M. Sodeoka, H. Egami, Y. Hamashima, 2010 .

Benzylic C-H trifluoromethylation of phenol derivatives.

Yuji Kawato, H. Egami, Y. Hamashima, 2015, Chemical communications.

Syntheses of methylated catechins and theaflavins using 2-nitrobenzenesulfonyl group to protect and deactivate phenol

Y. Hamashima, T. Asakawa, T. Kan, 2016, The Journal of Antibiotics.

Total Syntheses of (+)-Sesamin and (+)-Sesaminol

Y. Hamashima, T. Asakawa, T. Kan, 2014 .

Enantioselective Bromocyclization of Allylic Amides Mediated by Phosphorus Catalysis

Yuji Kawato, Y. Hamashima, 2018, Synlett.

Development of Anionic Phase-Transfer Catalysts for Asymmetric Fluorinations

H. Egami, Y. Hamashima, 2022, Journal of Synthetic Organic Chemistry, Japan.

Enantioselective 5-exo-Fluorocyclization of Ene-Oximes

H. Egami, Y. Hamashima, Tomoki Niwa, 2019, Molecules.

Asymmetric Fluorination of Cyclic Tetrasubstituted Alkenes with a Pendant Amide Groups under Dianionic Phase-Transfer Catalysis.

H. Egami, Y. Hamashima, Tomoki Niwa, 2018, Chemical & pharmaceutical bulletin.

Pd(II)-Catalyzed asymmetric addition reactions of 1,3-dicarbonyl compounds: Mannich-type reactions with N-Boc imines and three-component aminomethylation.

M. Sodeoka, Y. Hamashima, Naoki Sasamoto, 2008, Chemistry, an Asian journal.

Benzylic C—H Trifluoromethylation of Phenol Derivatives.

Yuji Kawato, H. Egami, Y. Hamashima, 2016 .

Amine-salt-controlled, catalytic asymmetric conjugate addition of various amines and asymmetric protonation.

M. Sodeoka, Y. Hamashima, H. Somei, 2004, Organic letters.

Catalytic enantioselective fluorination of oxindoles.

M. Sodeoka, Y. Hamashima, Toshiaki Suzuki, 2005, Journal of the American Chemical Society.

Epipolythiodiketopiperazine Alkaloids: Total Syntheses and Biological Activities

M. Sodeoka, Y. Hamashima, E. Iwasa, 2011 .

Catch and release of alkyne-tagged molecules in water by a polymer-supported cobalt complex.

M. Sodeoka, H. Egami, Y. Hamashima, 2011, Organic & biomolecular chemistry.

Catalytic Enantioselective Michael Reaction of 1,3‐Dicarbonyl Compounds via Formation of Chiral Palladium Enolate

M. Sodeoka, Y. Hamashima, Takeyuki Suzuki, 2005 .

[Acid-base catalysis of chiral Pd complexes: development of novel asymmetric reactions].

Y. Hamashima, 2005, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

Chemoselective hydrogenation reaction of unsaturated bonds in the presence of an o-nitrobenzenesulfonyl group.

Y. Hamashima, H. Sajiki, T. Asakawa, 2013, Organic letters.

A new entry to Pd-H chemistry: catalytic asymmetric conjugate reduction of enones with EtOH and a highly enantioselective synthesis of warfarin.

M. Sodeoka, Y. Hamashima, Y. Tsuchiya, 2006, Organic letters.

Pd(II)-catalyzed asymmetric addition of malonates to dihydroisoquinolines.

M. Sodeoka, Y. Hamashima, Naoki Sasamoto, 2006, Journal of the American Chemical Society.

Concise synthesis of binaphthol-derived chiral dicarboxylic acids

Yuji Kawato, H. Egami, Y. Hamashima, 2015 .

Highly enantioselective fluorination reactions of β-ketoesters and β-ketophosphonates catalyzed by chiral palladium complexes

M. Sodeoka, Y. Hamashima, Toshiaki Suzuki, 2006 .

An efficient catalytic enantioselective fluorination of β-ketophosphonates using chiral palladium complexes

M. Sodeoka, Y. Hamashima, Toshiaki Suzuki, 2005 .

An efficient enantioselective fluorination of various beta-ketoesters catalyzed by chiral palladium complexes.

M. Sodeoka, Y. Hamashima, L. Tamás, 2002, Journal of the American Chemical Society.

Recent Advances in Catalytic Enantioselective Fluorination Reactions

M. Sodeoka, Y. Hamashima, Sylvain Lectard, 2010 .

Acid-base catalysis using chiral palladium complexes

M. Sodeoka, Y. Hamashima, 2006 .

Catalytic Enantioselective α‐Fluorination of Carbonyl Compounds Using Chiral Transition Metal Complexes

M. Sodeoka, Y. Hamashima, 2008 .

Synthesis of optically active heterocyclic compounds using Pd-catalyzed asymmetric reactions as a key step

M. Sodeoka, Y. Hamashima, 2008 .

Catalytic Enantioselective α-Fluorination of Carbonyl Compounds Using Chiral Transition Metal Complexes

M. Sodeoka, Y. Hamashima, 2007 .

Asymmetric fluorination of alpha-aryl acetic acid derivatives with the catalytic system NiCl2-Binap/R3SiOTf/2,6-lutidine.

M. Sodeoka, Y. Hamashima, Toshiaki Suzuki, 2007, Angewandte Chemie.

Enantioselective fluorination of tert-butoxycarbonyl lactones and lactams catalyzed by chiral Pd(II)-bisphosphine complexes.

M. Sodeoka, Y. Hamashima, Toshiaki Suzuki, 2007, The Journal of organic chemistry.

Stereocontrolled total synthesis of hedyotol A.

Y. Hamashima, T. Asakawa, T. Kan, 2014, Organic letters.

Scope and mechanism of tandem aza-Michael reaction/enantioselective protonation using a Pd-μ-hydroxo complex under mild conditions buffered with amine salts.

M. Sodeoka, Y. Hamashima, Shoko Suzuki, 2011, Chemistry, an Asian journal.

Development of Novel Asymmetric Reactions Based on Acid-base Catalysis of Late Transition Metal Complexes

M. Sodeoka, Y. Hamashima, 2011 .

Asymmetric conjugate addition of α-keto esters to nitroolefins catalyzed by chiral CuII hydroxo complexes

M. Sodeoka, Y. Hamashima, R. Shimizu, 2010 .

Chiral Pd aqua complex-catalyzed asymmetric C-C bond-forming reactions: a Brønsted acid-base cooperative system.

M. Sodeoka, Y. Hamashima, 2009, Chemical communications.

Catalytic enantioselective aldol-type reaction of beta-ketosters with acetals.

M. Sodeoka, D. Hashizume, Y. Hamashima, 2008, Angewandte Chemie.

Catalytic asymmetric conjugate reduction with ethanol: A more reactive system Pd(II)–iPr-DUPHOS complex with molecular sieves 4A

M. Sodeoka, D. Hashizume, Y. Hamashima, 2008 .

Catalytic Asymmetric Aldol Reactions of Enolizable Carbon Pronucleophiles with Formaldehyde and Ethyl Glyoxylate

M. Sodeoka, Y. Hamashima, I. Fukuchi, 2007 .

Total Synthesis of TAN1251C via Diastereoselective Construction of the Azaspiro Skeleton.

Y. Ishikawa, Y. Hamashima, T. Asakawa, 2017, Organic letters.

A Catalytic Asymmetric Strecker‐Type Reaction: Interesting Reactivity Difference between TMSCN and HCN

M. Kanai, Y. Hamashima, M. Shibasaki, 2000 .

Mechanistic studies on the catalytic asymmetric Mannich-type reaction with dihydroisoquinolines and development of oxidative Mannich-type reactions starting from tetrahydroisoquinolines.

M. Sodeoka, D. Hashizume, Y. Hamashima, 2008, The Journal of organic chemistry.

Total synthesis of (-)-lemonomycin.

Y. Hamashima, T. Asakawa, T. Kan, 2012, Chemistry.

Practical and Scalable Organic Reactions with Flow Microwave Apparatus.

H. Egami, Y. Hamashima, 2018, Chemical record.

Dual-Role Catalysis by Thiobenzoic Acid in Cα–H Arylation under Photoirradiation

H. Egami, Y. Hamashima, Yuta Ito, 2020, ACS Catalysis.

Photofluorination of Aliphatic C-H Bonds Promoted by the Phthalimide Group.

Yuji Kawato, H. Egami, Y. Hamashima, 2018, Organic letters.

Thiocyanation of Aromatic and Heteroaromatic Compounds with 1-Chloro-1,2-benziodoxol-3-(1H)-one and (Trimethylsilyl)isothiocyanate.

H. Egami, Y. Hamashima, Yuta Ito, 2019, Chemical & pharmaceutical bulletin.

A Catalytic Asymmetric Strecker-Type Reaction: Interesting Reactivity Difference Between Tms-CN and HCN.

M. Kanai, Y. Hamashima, M. Shibasaki, 2000 .

A New Bifunctional Asymmetric Catalysis: An Efficient Catalytic Asymmetric Cyanosilylation of Aldehydes

Y. Hamashima, M. Shibasaki, D. Sawada, 1999 .

Enantioselective bromocyclization of allylic amides catalyzed by BINAP derivatives.

Yuji Kawato, H. Egami, Y. Hamashima, 2015, Organic letters.

(E)-3-[4-(Pent-4-en-1-yloxy)phenyl]acrylicc Acid

T. Okamoto, H. Egami, Y. Hamashima, 2018 .

Ammonium Salt-Accelerated Hydrazinolysis of Unactivated Amides: Mechanistic Investigation and Application to a Microwave Flow Process

Y. Hamashima, S. Akai, Y. Shimizu, 2019, Organic Process Research & Development.

Development of a highly efficient single-mode microwave applicator with a resonant cavity and its application to continuous flow syntheses

T. Okamoto, H. Egami, Y. Hamashima, 2015 .

Advanced dress-up chiral columns: New removable chiral stationary phases for enantioseparation of chiral carboxylic acids.

Wei Zhang, Koichi Inoue, T. Toyo’oka, 2015, Analytica chimica acta.

Catalytic asymmetric addition of beta-ketoesters to various imines by using chiral palladium complexes.

M. Sodeoka, Y. Hamashima, H. Somei, 2005, Angewandte Chemie.

Total syntheses of chaetocin and ent-chaetocin

M. Sodeoka, D. Hashizume, Y. Hamashima, 2011 .

Total synthesis of (+)-chaetocin and its analogues: their histone methyltransferase G9a inhibitory activity.

M. Sodeoka, Minoru Yoshida, A. Ito, 2010, Journal of the American Chemical Society.

Direct generation of nucleophilic chiral palladium enolate from 1,3-dicarbonyl compounds: catalytic enantioselective Michael reaction with enones.

M. Sodeoka, Y. Hamashima, Daido Hotta, 2002, Journal of the American Chemical Society.

Switching enantiofacial selectivities using one chiral source: catalytic enantioselective synthesis of the key intermediate for (20S)-camptothecin family by (S)-selective cyanosilylation of ketones.

M. Kanai, Y. Hamashima, M. Shibasaki, 2001, Journal of the American Chemical Society.

Catalytic enantioselective cyanosilylation of ketones: improvement of enantioselectivity and catalyst turn-over by ligand tuning

M. Kanai, Y. Hamashima, M. Shibasaki, 2001 .

Catalytic Enantioselective Cyanosilylation of Ketones

Y. Hamashima, M. Shibasaki, and Motomu Kanai, 2000 .

A New Bifunctional Asymmetric Catalysis: An Efficient Catalytic Asymmetric Cyanosilylation of Aldehydes.

M. Kanai, Y. Hamashima, M. Shibasaki, 1999 .

Desymmetrization of Bisallylic Amides through Catalytic Enantioselective Bromocyclization with BINAP Monoxide.

Yuji Kawato, H. Egami, Y. Hamashima, 2017, Chemistry.

Highly enantioselective cyanosilylation of aldehydes catalyzed by a Lewis acid–Lewis base bifunctional catalyst

M. Kanai, Y. Hamashima, M. Shibasaki, 2001 .

Design of a new bifunctional asymmetric catalyst from carbohydrates: application to catalytic asymmetric cyanosilylation of aldehydes and acetophenone

M. Kanai, Y. Hamashima, M. Shibasaki, 2000 .

Asymmetric Fluorofunctionalizations with Carboxylate‐Based Phase‐Transfer Catalysts

H. Egami, Y. Hamashima, 2023, Chemical record.

Enantioselective Protonationin the Aza-Michael Reaction Using a Combination of ChiralPd-µ-Hydroxo Complex with an Amine Salt

M. Sodeoka, Y. Hamashima, Shoko Suzuki, 2009 .

Mechanistic Details of Asymmetric Bromocyclization with BINAP Monoxide: Identification of Chiral Proton-Bridged Bisphosphine Oxide Complex and Its Application to Parallel Kinetic Resolution.

Yuji Kawato, Y. Hamashima, Kohei Watanabe, 2022, Journal of the American Chemical Society.

4.11 C–C Bond-Forming Reactions via Transmetallation using Silyl Enol Ethers

M. Sodeoka, Y. Hamashima, 2012 .

Catalytic Asymmetric α-Chlorination of 3-Acyloxazolidin-2-one with a Trinary Catalytic System

M. Sodeoka, Y. Hamashima, T. Tsuchimoto, 2011 .

Stereocontrolled total synthesis of (+)-UCS1025A.

Y. Hamashima, T. Asakawa, T. Kan, 2012, Angewandte Chemie.

Highly Enantioselective Bromocyclization of Allylic Amides with a P/P=O Double-Site Lewis Base Catalyst.

Naoki Morita, Yuji Kawato, H. Egami, 2016, Chemistry.

Catalytic Enantioselective Aldol‐Type Reaction of β‐Ketoesters with Acetals.

M. Sodeoka, D. Hashizume, Y. Hamashima, 2008 .

Stereoselective construction of 2-vinyl 3-hydroxybenzopyran rings: total syntheses of teadenols A and B.

Y. Hamashima, T. Asakawa, T. Kan, 2016, Organic & biomolecular chemistry.

Catalytic desymmetrization of cyclohexadienes by asymmetric bromolactonization.

Y. Hamashima, T. Asakawa, T. Kan, 2012, Organic letters.

C-Alkylation of N-alkylamides with styrenes in air and scale-up using a microwave flow reactor.

T. Okamoto, H. Egami, Y. Hamashima, 2018, Organic & biomolecular chemistry.

Scalable Microwave-Assisted Johnson–Claisen Rearrangement with a Continuous Flow Microwave System

T. Okamoto, H. Egami, Y. Hamashima, 2018, Organic Process Research & Development.

A catalytic asymmetric strecker-type reaction promoted by Lewis acid-Lewis base bifunctional catalyst.

M. Kanai, Y. Hamashima, M. Shibasaki, 2000, Chemical & pharmaceutical bulletin.

Catalytic enantioselective fluorination of oxindoles.

M. Sodeoka, Y. Hamashima, Toshiaki Suzuki, 2005, Journal of the American Chemical Society.

Redox-neutral C–H cyanation of tetrahydroisoquinolines under photoredox catalysis

H. Egami, Y. Hamashima, Takafumi Ide, 2018, Tetrahedron Letters.

Amide-Ligand-Promoted Silver-Catalyzed C-H Fluorination via Radical/Polar Crossover.

Y. Hamashima, Y. Fujiwara, K. Yamashita, 2023, The Journal of organic chemistry.

Synthetic Study on Pactamycin: Stereoselective Synthesis of the Cyclopentane Core Framework.

Y. Hamashima, T. Asakawa, T. Kan, 2017, Organic letters.

Enhancement of target toxin neutralization effect in vivo by PEGylation of multifunctionalized lipid nanoparticles.

N. Oku, Hiroyuki Koide, H. Egami, 2021, Biochemical and biophysical research communications.

Unnatural enantiomer of chaetocin shows strong apoptosis-inducing activity through caspase-8/caspase-3 activation.

M. Sodeoka, Y. Hamashima, Y. Teng, 2010, Bioorganic & medicinal chemistry letters.

Synthesis of Theaflavins via Biomimetic Oxidative Coupling Reactions

Y. Hamashima, T. Asakawa, T. Kan, 2013, Synlett.

Difunctionalization of Alkenes Using 1-Chloro-1,2-benziodoxol-3-(1H)-one.

Yuji Kawato, H. Egami, Y. Hamashima, 2016, The Journal of organic chemistry.

Stereocontrolled Total Synthesis of Sphingofungin E

Y. Hamashima, T. Asakawa, T. Kan, 2013 .

Practical Total Syntheses of Acromelic Acids A and B.

Y. Hamashima, T. Asakawa, T. Kan, 2014, Chemical & pharmaceutical bulletin.

Stereocontrolled Total Synthesis of Sphingofungin E.

Y. Hamashima, T. Asakawa, T. Kan, 2014 .

Epidithiodiketopiperazine as a pharmacophore for protein lysine methyltransferase G9a inhibitors: reducing cytotoxicity by structural simplification.

M. Sodeoka, Minoru Yoshida, A. Ito, 2013, Bioorganic & medicinal chemistry letters.

2-[(Neopentyl glycolato)boryl]phenyl Triflates and Halides for Fluoride Ion-Mediated Generation of Functionalized Benzynes

Y. Hamashima, S. Akai, Takashi Ikawa, 2015 .

Design of Synthetic Polymer Nanoparticles Specifically Capturing Indole, a Small Toxic Molecule.

Y. Hoshino, N. Oku, Hiroyuki Koide, 2019, Biomacromolecules.

Practical synthesis of natural plant-growth regulator 2-azahypoxanthine, its derivatives, and biotin-labeled probes.

Y. Hamashima, T. Asakawa, T. Kan, 2014, Organic & biomolecular chemistry.

Dianionic Phase-Transfer Catalyst for Asymmetric Fluoro-cyclization.

Yuji Kawato, H. Egami, Y. Hamashima, 2018, Journal of the American Chemical Society.

18F-Labeled dihydromethidine: positron emission tomography radiotracer for imaging of reactive oxygen species in intact brain.

S. Nishiyama, H. Tsukada, H. Egami, 2020, Organic & biomolecular chemistry.

Enantioselective Allyl-, and Allenylboration of Aldehydes Catalyzed by Chiral Hydroxyl Carboxylic Acid

Yuji Kawato, H. Egami, Y. Hamashima, 2017, Synlett.

Synthesis and biological activities of chaetocin and its derivatives

M. Sodeoka, Y. Hamashima, Y. Teng, 2012 .

Enantioselective Synthesis of Bromodifluoromethyl-containing Oxazolines by Concerted Lewis/Brønsted Base Catalysis with Chiral Bisphosphine Oxide.

Y. Hamashima, K. Yamashita, Ryouichi Hirokawa, 2023, Chemistry - An Asian Journal.

Enantioselective Fluorination Reactions Catalyzed by Chiral Palladium Complexes

M. Sodeoka, Y. Hamashima, 2006 .

Catalytic asymmetric mono-fluorination of α-keto esters: synthesis of optically active β-fluoro-α-hydroxy and β-fluoro-α-amino acid derivatives.

M. Sodeoka, Y. Hamashima, Y. Kitamura, 2012, Angewandte Chemie.

Regio- and chemoselective Csp3–H arylation of benzylamines by single electron transfer/hydrogen atom transfer synergistic catalysis

Yuji Kawato, H. Egami, Y. Hamashima, 2018, Chemical science.

A Short-Step Asymmetric Synthesisof Dehydrodiconiferyl Alcohol via C-H InsertionReaction

Y. Hamashima, T. Asakawa, T. Kan, 2012 .

Stereocontrolled total synthesis of (+)-UCS1025A.

Y. Hamashima, T. Asakawa, T. Kan, 2012, Angewandte Chemie.

Practical total syntheses of acromelic acids A and B.

Y. Hamashima, T. Asakawa, T. Kan, 2014, Organic letters.