Keliang Liu

Liang Xu, Keliang Liu, Zeye Han, 2018, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

DNA Triplex-Based Complexes Display Anti-HIV-1-Cell Fusion Activity.

Tao Zhang, Liang Xu, Keliang Liu, 2015, Nucleic acid therapeutics.

DNA Duplexes with Hydrophobic Modifications Inhibit Fusion between HIV-1 and Cell Membranes

Wei Chen, Liang Xu, Keliang Liu, 2013, Antimicrobial Agents and Chemotherapy.

Covalent fusion inhibitors targeting HIV-1 gp41 deep pocket

L. Lai, Shuangyu Bi, Keliang Liu, 2012, Amino Acids.

Design and Biological Evaluation of m-Xylene Thioether-stapled Short Helical Peptides Targeting the HIV-1 gp41 Hexameric Coiled-Coil Fusion Complex.

Wei Xu, Lu Lu, Shibo Jiang, 2019, Journal of medicinal chemistry.

Improved Pharmacological and Structural Properties of HIV Fusion Inhibitor AP3 over Enfuvirtide: Highlighting Advantages of Artificial Peptide Strategy

Q. Wang, Rongguang Zhang, Lu Lu, 2015, Scientific Reports.

Zwitterionic polymeric micelles that undergo a pH-triggered positive charge for enhanced cellular uptake

Huiyan Jia, Youjia Cao, Keliang Liu, 2015 .

Interactions between different generation HIV‐1 fusion inhibitors and the putative mechanism underlying the synergistic anti‐HIV‐1 effect resulting from their combination

Liang Xu, Shibo Jiang, Keliang Liu, 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Site-specific Isopeptide Bridge Tethering of Chimeric gp41 N-terminal Heptad Repeat Helical Trimers for the Treatment of HIV-1 Infection

Lu Lu, Shibo Jiang, L. Ye, 2016, Scientific reports.

An effective conjugation strategy for designing short peptide-based HIV-1 fusion inhibitors.

Keliang Liu, Chao Wang, Yuxian He, 2016, Organic & biomolecular chemistry.

De novo design of isopeptide bond-tethered triple-stranded coiled coils with exceptional resistance to unfolding and proteolysis: implication for developing antiviral therapeutics† †Electronic supplementary information (ESI) available: General materials, methods and the details. See DOI: 10.1039/c5s

Lu Lu, Shibo Jiang, Keliang Liu, 2015, Chemical science.

An artificial peptide-based HIV-1 fusion inhibitor containing M-T hook structure exhibiting improved antiviral potency and drug resistance profile

Lu Lu, Shibo Jiang, Keliang Liu, 2015 .

A novel bispecific peptide HIV-1 fusion inhibitor targeting the N-terminal heptad repeat and fusion peptide domains in gp41

Lu Lu, Shibo Jiang, Keliang Liu, 2016, Amino Acids.

Artificial peptides conjugated with cholesterol and pocket-specific small molecules potently inhibit infection by laboratory-adapted and primary HIV-1 isolates and enfuvirtide-resistant HIV-1 strains.

Liang Xu, Lu Lu, Shibo Jiang, 2014, The Journal of antimicrobial chemotherapy.

Novel anti-HIV peptides containing multiple copies of artificially designed heptad repeat motifs

A. Debnath, Shibo Jiang, Keliang Liu, 2008, Biochemical and Biophysical Research Communications.

Synthesis, biophysical characterization, and anti-HIV-1 fusion activity of DNA helix-based inhibitors with a p-benzyloxyphenyl substituent at the 5'-nucleobase site.

Liang Xu, Keliang Liu, Zeye Han, 2018, Bioorganic & medicinal chemistry letters.

Design of highly potent HIV fusion inhibitors based on artificial peptide sequences.

Liang Xu, Lu Lu, Shibo Jiang, 2012, Chemical communications.

In vivo characterization of a novel GnRH (gonadotropin-releasing hormone) antagonist, LXT-101, in normal male rats

Keliang Liu, Wenxia Zhou, Yongxiang Zhang, 2006, Regulatory Peptides.

Fibre–type X–ray diffraction patterns from single crystals of triple helical DNA

K. Parris, V. Sasisekharan, Keliang Liu, 1994, Nature Structural Biology.

Enhanced cell uptake of superparamagnetic iron oxide nanoparticles through direct chemisorption of FITC-Tat-PEG₆₀₀-b-poly(glycerol monoacrylate).

Keliang Liu, Husheng Yan, Chenhong Wang, 2012, International journal of pharmaceutics.

Nanostructures from the self‐assembly of α‐helical peptide amphiphiles

Xin Ma, Qingbin Meng, Keliang Liu, 2014, Journal of peptide science : an official publication of the European Peptide Society.

Biocompatible superparamagnetic iron oxide nanoparticle dispersions stabilized with poly(ethylene glycol)-oligo(aspartic acid) hybrids.

Youjia Cao, Keliang Liu, M. Guo, 2007, Journal of biomedical materials research. Part A.

Design, synthesis, and activity evaluation of novel erythropoietin mimetic peptides.

Siliang Feng, Keliang Liu, Chenhong Wang, 2018, Bioorganic & medicinal chemistry letters.

A facile surfactant critical micelle concentration determination.

M. Gochin, Keliang Liu, Lifeng Cai, 2011, Chemical communications.

Covalent fusion inhibitors targeting HIV-1 gp41 deep pocket

L. Lai, Shuangyu Bi, Keliang Liu, 2013, Amino Acids.

Increase of anti-HIV activity of C-peptide fusion inhibitors using a bivalent drug design approach.

Keliang Liu, Lifeng Cai, Huifang Xue, 2013, Bioorganic & medicinal chemistry letters.

A structure-activity relationship study for 2'-deoxyadenosine analogs at A9 position in the catalytic core of 10-23 DNAzyme for rate enhancement.

Keliang Liu, Junlin He, M. Cheng, 2012, Nucleic acid therapeutics.

A novel strategy of chemical modification for rate enhancement of 10-23 DNAzyme: a combination of A9 position and 8-aza-7-deaza-2'-deoxyadenosine analogs.

Keliang Liu, Junlin He, M. Cheng, 2011, Organic & biomolecular chemistry.

Multifunctional superparamagnetic nanocarriers with folate-mediated and pH-responsive targeting properties for anticancer drug delivery.

Keliang Liu, Miao Guo, Keliang Liu, 2011, Biomaterials.

DNA duplex-supported artificial esterase mimicking by cooperative grafting functional groups.

Liang Xu, Keliang Liu, Junlin He, 2013, Biochemical and biophysical research communications.

Hydroxyl-Functionalized DNAs with Different Linkers and Their Complmentary Duplex Stability

Liang Xu, Keliang Liu, Junlin He, 2010, Nucleosides, nucleotides & nucleic acids.

Superparamagnetic iron oxide nanoparticles coated with a folate-conjugated polymer

Keliang Liu, Husheng Yan, Chenhong Wang, 2009 .

Heteromeric Assembled Polypeptidic Artificial Hydrolases with a Six‐Helical Bundle Scaffold

Shibo Jiang, Keliang Liu, Lifeng Cai, 2011, Chembiochem : a European journal of chemical biology.

Enhanced loading of doxorubicin into polymeric micelles by a combination of ionic bonding and hydrophobic effect, and the pH-sensitive and ligand-mediated delivery of loaded drug

Keliang Liu, M. Guo, Zhen-Ya Xu, 2013 .

Hydroxyl-Functionalized DNA: An Efficient Orthogonal Protecting Strategy and Duplex Stability

Liang Xu, Keliang Liu, Junlin He, 2009, Nucleosides, nucleotides & nucleic acids.

Site-directed PEGylations of Thymosin α 1 Analogs and Evaluation of Their Immunoactivity

Keliang Liu, Yongxiang Zhang, Xiaoyu Xu, 2009 .

NMR structure of a parallel-stranded DNA duplex at atomic resolution.

F. B. Howard, Keliang Liu, S. Bhaumik, 2002, Nucleic acids research.

Catalytic cleavage activities of 10-23 DNAzyme analogs functionalized with an amino group in its catalytic core

Keliang Liu, Junlin He, M. Cheng, 2012 .

Fe3O4 Nanoparticles coated with homopolymers of glycerol mono(meth)acrylate and their block copolymers

Keliang Liu, Husheng Yan, Yuanqin Liu, 2005 .

Enhanced gene transfection efficiency by use of peptide vectors containing laminin receptor-targeting sequence YIGSR.

Sen Yang, Zhao Meng, Ziyao Kang, 2018, Nanoscale.

Co‐administration of a charge‐conversional dendrimer enhances antitumor efficacy of conventional chemotherapy

Jun Cao, Keliang Liu, Husheng Yan, 2018, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Tunable self-assembled peptide amphiphile nanostructures.

Qingbin Meng, Qingbin Meng, Keliang Liu, 2012, Langmuir : the ACS journal of surfaces and colloids.

Morpholino-terminated dendrimer shows enhanced tumor pH-triggered cellular uptake, prolonged circulation time, and low cytotoxicity

Keliang Liu, Husheng Yan, Cuiping Yang, 2016 .

Hemiasterlin Analogues with Unnatural Amino Acids at the N-Terminal and Their Inhibitory Activity on Tumor Cells

Keliang Liu, Junlin He, Yongxiang Zhang, 2009, International Journal of Peptide Research and Therapeutics.

12 Multifunctional Magnetic Hybrid Nanoparticles as a Nanomedical Platform for Cancer-Targeted Imaging and Therapy

Keliang Liu, M. Guo, Husheng Yan, 2018 .

Sustained drug release and cancer treatment by an injectable and biodegradable cyanoacrylate-based local drug delivery system.

Keliang Liu, Shan Liu, Yongjia Tang, 2018, Journal of materials chemistry. B.

Biochemistry and biophysics of HIV-1 gp41 - membrane interactions and implications for HIV-1 envelope protein mediated viral-cell fusion and fusion inhibitor design.

M. Gochin, Keliang Liu, Lifeng Cai, 2011, Current topics in medicinal chemistry.

Peptide-based gene delivery vectors.

Ziyao Kang, Qingbin Meng, Keliang Liu, 2019, Journal of materials chemistry. B.

Precisely Designed Isopeptide Bridge-Crosslinking Endows Artificial Hydrolases with High Stability and Catalytic Activity under Extreme Denaturing Conditions.

Keliang Liu, Chao Wang, M. Cheng, 2017, Chemistry, an Asian journal.

Short cyclic peptides derived from the C-terminal sequence of α1-antitrypsin exhibit significant anti-HIV-1 activity.

Keliang Liu, Shuwen Liu, F. Yu, 2012, Bioorganic & medicinal chemistry letters.

Conjugation of a nonspecific antiviral sapogenin with a specific HIV fusion inhibitor: a promising strategy for discovering new antiviral therapeutics.

Lu Lu, Shibo Jiang, Qian Wang, 2014, Journal of medicinal chemistry.

Discovery of Hydrocarbon-Stapled Short α-Helical Peptides as Promising Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Fusion Inhibitors

Shibo Jiang, Keliang Liu, S. Xia, 2018, Journal of medicinal chemistry.

2-(4-Methylsulfonylaminophenyl) propanamide TRPV1 antagonists: Structure-activity relationships in the B and C-regions.

Vladimir A. Pavlyukovets, P. Blumberg, Keliang Liu, 2012, Bioorganic & medicinal chemistry.

Multilayer nanoparticles with a magnetite core and a polycation inner shell as pH-responsive carriers for drug delivery.

Youjia Cao, Keliang Liu, M. Guo, 2010, Nanoscale.

Design, synthesis, and biological evaluation of highly potent small molecule-peptide conjugates as new HIV-1 fusion inhibitors.

Liang Xu, Jinglai Li, Lu Lu, 2013, Journal of medicinal chemistry.

A cross-linking strategy provides a new generation of biodegradable and biocompatible cyanoacrylate medical adhesives.

Q. Meng, Qingbin Meng, Keliang Liu, 2016, Journal of materials chemistry. B.

A Drug Carrier for Sustained Zero-Order Release of Peptide Therapeutics

Yongjun Zhang, Ying Guan, Qingbin Meng, 2017, Scientific Reports.

De Novo Design of α-Helical Lipopeptides Targeting Viral Fusion Proteins: A Promising Strategy for Relatively Broad-Spectrum Antiviral Drug Discovery

Shibo Jiang, Keliang Liu, S. Xia, 2018, Journal of medicinal chemistry.

Supercoiling Structure-Based Design of a Trimeric Coiled-Coil Peptide with High Potency against HIV-1 and Human β-Coronavirus Infection

S. Huo, Lu Lu, Shibo Jiang, 2021, Journal of medicinal chemistry.

Hydrophobic mutations in buried polar residues enhance HIV-1 gp41 N-terminal heptad repeat–C-terminal heptad repeat interactions and C-peptides’ anti-HIV activity

Lu Lu, Shibo Jiang, Keliang Liu, 2014, AIDS.

Polyion complexes of a cationic antimicrobial peptide as a potential systemically administered antibiotic

Xiaoli Wei, Siliang Feng, Keliang Liu, 2019, International journal of pharmaceutics.

Rationally Designed Anti-HIV Peptides Containing Multifunctional Domains as Molecule Probes for Studying the Mechanisms of Action of the First and Second Generation HIV Fusion Inhibitors*

Shibo Jiang, Keliang Liu, Na Xue, 2008, Journal of Biological Chemistry.

Peptides and Peptidomimetics as Tools to Probe Protein-Protein Interactions – Disruption of HIV-1 gp41 Fusion Core and Fusion Inhibitor Design

Keliang Liu, Lifeng Cai, W. Shi, 2012 .

Using a bifunctional polymer for the functionalization of Fe3O4 nanoparticles

Siliang Feng, Keliang Liu, Husheng Yan, 2012 .

Cisplatin-loaded polymer/magnetite composite nanoparticles as multifunctional therapeutic nanomedicine

Keliang Liu, M. Guo, Husheng Yan, 2014, Chinese Journal of Polymer Science.

An effective strategy for recapitulating N-terminal heptad repeat trimers in enveloped virus surface glycoproteins for therapeutic applications† †Electronic supplementary information (ESI) available: General materials, methods, and the details. See DOI: 10.1039/c5sc04046a

Lu Lu, Shibo Jiang, Keliang Liu, 2015, Chemical science.

Multifunctional superparamagnetic nanocarriers with folate-mediated and pH-responsive targeting properties for anticancer drug delivery.

Keliang Liu, M. Guo, Husheng Yan, 2011, Biomaterials.

Hydrophobic mutations in buried polar residues enhance HIV-1 gp41 N-terminal heptad repeat–C-terminal heptad repeat interactions and C-peptides’ anti-HIV activity

Lu Lu, Shibo Jiang, Keliang Liu, 2014, AIDS.

Peptides and Peptidomimetics as Tools to Probe Protein-Protein Interactions – Disruption of HIV-1 gp41 Fusion Core and Fusion Inhibitor Design

Keliang Liu, Lifeng Cai, W. Shi, 2012 .

Peptide amphiphiles with multifunctional fragments promoting cellular uptake and endosomal escape as efficient gene vectors.

Liang Xu, Zhao Meng, Qingbin Meng, 2015, Journal of materials chemistry. B.

Design, synthesis, and evaluation of water-soluble morpholino-decorated paclitaxel prodrugs with remarkably decreased toxicity.

Siliang Feng, Keliang Liu, Chenhong Wang, 2016, Bioorganic & medicinal chemistry letters.

A novel strategy of chemical modification for rate enhancement of 10-23 DNAzyme: a combination of A9 position and 8-aza-7-deaza-2'-deoxyadenosine analogs.

Keliang Liu, Junlin He, M. Cheng, 2011, Organic & biomolecular chemistry.

Studies on the Effect of Thymine-Mercury-Thymine Stem as a Structural or Functional Motif in DNAzymes

Keliang Liu, Junlin He, Wei-Heng Rong, 2014, Nucleosides, nucleotides & nucleic acids.

d(TGGGAG) with 5'-nucleobase-attached large hydrophobic groups as potent inhibitors for HIV-1 envelop proteins mediated cell-cell fusion.

Liang Xu, Keliang Liu, Junlin He, 2011, Bioorganic & medicinal chemistry letters.