K. Shen

发表

KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1

Gregory A. Wyant, D. Sabatini, W. Frankel, 2017, Nature.

KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1

Gu, Gregory A. Wyant, D. Sabatini, 2017, Nature.

The CASTOR Proteins Are Arginine Sensors for the mTORC 1 Pathway Graphical

Steven P. Gygi, Tim Wang, Melanie P. Gygi, 2016 .

Sestrin2 is a leucine sensor for the mTORC1 pathway

D. Sabatini, J. Cantor, Lynne Chantranupong, 2016, Science.

Signal recognition particle: an essential protein-targeting machine.

Xin Zhang, K. Shen, S. Shan, 2013, Annual review of biochemistry.

Synergistic actions between the SRP RNA and translating ribosome allow efficient delivery of the correct cargos during cotranslational protein targeting.

Xin Zhang, K. Shen, S. Shan, 2011, RNA.

Transient tether between the SRP RNA and SRP receptor ensures efficient cargo delivery during cotranslational protein targeting

K. Shen, S. Shan, 2010, Proceedings of the National Academy of Sciences.

Sestrin 2 is a leucine sensor for the mTORC 1 pathway

D. Sabatini, Lynne Chantranupong, Rachel L. Wolfson, 2016 .

A New Crosslinking Assay to Study Guanine Nucleotide Binding in the Gtr Heterodimer of S. cerevisiae

K. Shen, Dylan Doxsey, Kristen Veinotte, 2022, Small GTPases.

The amino acid transporter SLC38A9 is a key component of a lysosomal membrane complex that signals arginine sufficiency to mTORC1

Gregory A. Wyant, B. Sabatini, D. Sabatini, 2015 .

Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant

Pardis C Sabeti, S. Schaffner, J. Luban, 2020, Cell.

Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant

Pardis C Sabeti, S. Schaffner, J. Luban, 2020, bioRxiv.

The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway

Gregory A. Wyant, S. Gygi, D. Sabatini, 2016, Cell.

Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism.

Zhiheng Yu, K. Shen, H. Chou, 2022, Molecular cell.

Arg-78 of Nprl2 catalyzes GATOR1-stimulated GTP hydrolysis by the Rag GTPases

D. Sabatini, X. Gu, K. Shen, 2019, The Journal of Biological Chemistry.

Architecture of the human GATOR1 and GATOR1–Rag GTPases complexes

D. Sabatini, E. Brignole, Rick Huang, 2018, Nature.

A diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity.

Andrew H. Beck, David M Sabatini, Andrew H Beck, 2014, Cancer discovery.

Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1

Gregory A. Wyant, B. Sabatini, D. Sabatini, 2015, Science.

Ragulator and SLC38A9 activate the Rag GTPases through noncanonical GEF mechanisms

D. Sabatini, K. Shen, 2018, Proceedings of the National Academy of Sciences.

C7orf59/LAMTOR4 phosphorylation and structural flexibility modulate Ragulator assembly

D. Sabatini, F. Gozzo, R. Aparício, 2019, FEBS open bio.

Cryo-EM Structure of the Human FLCN-FNIP2-Rag-Ragulator Complex

D. Sabatini, K. B. Rogala, Rick Huang, 2019, Cell.

Architecture of the human GATOR 1 and GATOR 1 – Rag GTPases complexes Citation

D. Sabatini, E. Brignole, Rick Huang, 2018 .

Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability.

D. Sabatini, K. Shen, Abigail Choe, 2017, Molecular cell.

Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability.

D. Sabatini, K. Shen, Abigail Choe, 2017, Molecular cell.

The structural basis of FtsY recruitment and GTPase activation by SRP RNA.

N. Ban, F. Voigts-Hoffmann, K. Shen, 2013, Molecular cell.

The Crystal Structure of the Signal Recognition Particle in Complex with Its Receptor

Jennifer A. Doudna, Kuang Shen, J. Doudna, 2011, Science.

Analyzing Single-Molecule Protein Transportation Experiments via Hierarchical Hidden Markov Models

Yang Chen, S C Kou, Kuang Shen, 2016, Journal of the American Statistical Association.

Conformational dynamics and allosteric modulation of the SARS-CoV-2 spike

James B. Munro, J. Luban, Yang Wang, 2021, bioRxiv.

Mechanism of an ATP-independent Protein Disaggregase

S. L. Mayo, Alex Nisthal, K. Shen, 2013, The Journal of Biological Chemistry.

Activated GTPase movement on an RNA scaffold drives cotranslational protein targeting

T. Ha, K. Shen, Sinan Arslan, 2012, Nature.

Ribosome profiling reveals novel regulation of C9ORF72 GGGGCC repeat-containing RNA translation

J. Richter, K. Shen, Botao Liu, 2021, RNA.

ATP-independent reversal of a membrane protein aggregate by a chloroplast SRP

Tony Z. Jia, S. Doniach, K. Shen, 2010, Nature Structural &Molecular Biology.

Conformational dynamics and allosteric modulation of the SARS-CoV-2 spike

James B. Munro, J. Luban, Yang Wang, 2022, eLife.

Two-step membrane binding by the bacterial SRP receptor enable efficient and accurate Co-translational protein targeting

Thomas F. Miller, J. Groves, K. Shen, 2017, eLife.

SecYEG activates GTPases to drive the completion of cotranslational protein targeting

K. Shen, F. Duong, Kush Dalal, 2013, The Journal of cell biology.

SARS-CoV-2 Spike protein variant D614G increases infectivity and retains sensitivity to antibodies that target the receptor binding domain

Pardis C Sabeti, S. Schaffner, J. Luban, 2020, bioRxiv.

S:D614G and S:H655Y are gateway mutations that act epistatically to promote SARS-CoV-2 variant fitness

James B. Munro, J. Luban, Xuping Xie, 2023, bioRxiv.

An interdomain hydrogen bond in the Rag GTPases maintains stable mTORC1 signaling in sensing amino acids

K. Shen, S. Egri, 2021, The Journal of biological chemistry.

SARS-CoV-2 Spike protein variant D614G increases infectivity and retains sensitivity to antibodies that target the receptor binding domain [preprint]

Pardis C Sabeti, S. Schaffner, J. Luban, 2020 .

Structure of the Schizosaccharomyces pombe Gtr-Lam complex reveals evolutionary divergence of mTORC1-dependent amino acid sensing

Jeng-Yih Chang, K. Shen, Chen Xu, 2023, Structure.

Redundant electrostatic interactions between GATOR1 and the Rag GTPase heterodimer drive efficient amino acid sensing in human cells

K. Shen, S. Egri, Dylan Doxsey, 2023, The Journal of biological chemistry.

Molecular Mechanism of GTPase Activation at the Signal Recognition Particle (SRP) RNA Distal End*

J. Feigon, K. Shen, Yaqiang Wang, 2013, The Journal of Biological Chemistry.

Detergent modulates the conformational equilibrium of SARS-CoV-2 Spike during cryo-EM structural determination

James B. Munro, J. Luban, K. Shen, 2023, Nature communications.