D. G. Wansink

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Intracellular Distribution and Nuclear Activity of Antisense Oligonucleotides After Unassisted Uptake in Myoblasts and Differentiated Myotubes In Vitro

N. Datson, B. Wieringa, A. González-Barriga, 2017, Nucleic acid therapeutics.

Expanded CUG repeats in DMPK transcripts adopt diverse hairpin conformations without influencing the structure of the flanking sequences

B. Wieringa, D. G. Wansink, R. V. van Cruchten, 2019, RNA.

Deletion of the CTG Expansion in Myotonic Dystrophy Type 1 Reverses DMPK Aberrant Methylation in Human Embryonic Stem Cells but not Affected Myoblasts

R. Eiges, D. G. Wansink, F. Zahdeh, 2019, bioRxiv.

Antisense transcription of the myotonic dystrophy locus yields low-abundant RNAs with and without (CAG)n repeat

Eric T. Wang, E. Wang, S. V. van Heeringen, 2017, RNA biology.

Abnormal actomyosin assembly in proliferating and differentiating myoblasts upon expression of a cytosolic DMPK isoform.

H. Pluk, J. Fransen, B. Wieringa, 2011, Biochimica et biophysica acta.

Somatic expansion behaviour of the (CTG)n repeat in myotonic dystrophy knock-in mice is differentially affected by Msh3 and Msh6 mismatch-repair proteins.

M. Nelen, B. Wieringa, D. G. Wansink, 2002, Human molecular genetics.

Constitutive and regulated modes of splicing produce six major myotonic dystrophy protein kinase (DMPK) isoforms with distinct properties.

B. Wieringa, D. G. Wansink, G. Jansen, 2000, Human molecular genetics.

Transgenic overexpression of human DMPK accumulates into hypertrophic cardiomyopathy, myotonic myopathy and hypotension traits of myotonic dystrophy.

Santiago Reyes, Andre Terzic, J. Strommen, 2004, Human molecular genetics.

DMPK protein isoforms are differentially expressed in myogenic and neural cell lineages

Ralph J A Oude Ophuis, B. Wieringa, S. Mulders, 2009, Muscle & nerve.

Chromosome-wide nucleosome replacement and H3.3 incorporation during mammalian meiotic sex chromosome inactivation

L. Ramos, D. G. Wansink, P. Boer, 2007, Nature Genetics.

Human Male Meiotic Sex Chromosome Inactivation

L. Ramos, P. de Boer, D. G. Wansink, 2012, PloS one.

Cell Membrane Integrity in Myotonic Dystrophy Type 1: Implications for Therapy

B. Wieringa, A. González-Barriga, J. Kranzen, 2014, Neuromuscular Disorders.

Somatic CTG•CAG repeat instability in a mouse model for myotonic dystrophy type 1 is associated with changes in cell nuclearity and DNA ploidy

B. Wieringa, D. G. Wansink, W. J. van den Broek, 2007, BMC Molecular Biology.

Organization of (pre-)mRNA metabolism in the cell nucleus

L. Jong, D. G. Wansink, R. Driel, 2004, Molecular Biology Reports.

Fluorescent labeling of nascent RNA reveals transcription by RNA polymerase II in domains scattered throughout the nucleus

B. van Steensel, R. van Driel, W. Schul, 1993, The Journal of cell biology.

In vitro splicing of pre-mRNA containing bromouridine

L. Jong, D. G. Wansink, R. Nelissen, 1994, Molecular Biology Reports.

Ultrastructural localization of active genes in nuclei of A431 cells

R. van Driel, L. de Jong, O. Sibon, 1996, Journal of cellular biochemistry.

Mild impairment of motor nerve repair in mice lacking PTP-BL tyrosine phosphatase activity.

F. Oerlemans, B. Wieringa, G. Adema, 2004, Physiological genomics.

Fluorescent labeling of nascent RNA in the cell nucleus using 5-Bromouridine 5'-Triphosphate.

L. Jong, D. G. Wansink, A. Motley, 1994 .

Design and Analysis of Effects of Triplet Repeat Oligonucleotides in Cell Models for Myotonic Dystrophy

J. Fransen, B. Wieringa, A. González-Barriga, 2013, Molecular therapy. Nucleic acids.

248th ENMC International Workshop: Myotonic dystrophies: Molecular approaches for clinical purposes, framing a European molecular research network, Hoofddorp, the Netherlands, 11–13 October 2019

B. Engelen, B. Schoser, D. G. Wansink, 2020, Neuromuscular Disorders.

The nuclear concentration required for antisense oligonucleotide activity in myotonic dystrophy cells

M. Willemse, R. Brock, M. Hällbrink, 2019, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

In Vitro Synthesis and RNA Structure Probing of CUG Triplet Repeat RNA.

D. G. Wansink, R. V. van Cruchten, Remco T P van Cruchten, 2020, Methods in molecular biology.

Myotonic dystrophy type 2 (DM2) and related disorders Report of the 180th ENMC Workshop including guidelines on diagnostics and management 3–5 December 2010, Naarden, The Netherlands

G. Meola, G. Bassez, W. Kress, 2011, Neuromuscular Disorders.

Nuclear domains and the nuclear matrix.

B. van Steensel, R. van Driel, W. Schul, 1995, International review of cytology.

Localization of the glucocorticoid receptor in discrete clusters in the cell nucleus.

B. van Steensel, B. Steensel, L. Jong, 1995, Journal of cell science.

(CTG)n repeat-mediated dysregulation of MBNL1 and MBNL2 expression during myogenesis in DM1 occurs already at the myoblast stage

M. Willemse, D. G. Wansink, Remco T P van Cruchten, 2019, PloS one.

Trinucleotide-repeat expanded and normal DMPK transcripts contain unusually long poly(A) tails despite differential nuclear residence.

B. Wieringa, I. D. van Kessel, D. G. Wansink, 2017, Biochimica et biophysica acta. Gene regulatory mechanisms.

CRISPR/Cas9-Induced (CTG⋅CAG)n Repeat Instability in the Myotonic Dystrophy Type 1 Locus: Implications for Therapeutic Genome Editing

M. Willemse, B. Wieringa, V. Mouly, 2017, Molecular therapy : the journal of the American Society of Gene Therapy.

Triplet-repeat oligonucleotide-mediated reversal of RNA toxicity in myotonic dystrophy

B. Wieringa, D. Furling, T. M. Wheeler, 2009, Proceedings of the National Academy of Sciences.

Phosphorylation target site specificity for AGC kinases DMPK E and lats2

B. Wieringa, H. Venselaar, D. G. Wansink, 2012, Journal of cellular biochemistry.

Clinical improvement of DM1 patients reflected by reversal of disease-induced gene expression in blood

J. Glennon, S. Treweek, Hanns Lochmüller, 2022, BMC Medicine.

The mouse mismatch repair protein, MSH3, is a nucleoplasmic protein that aggregates into denser nuclear bodies under conditions of stress

D. G. Wansink, H. te Riele, I. Holt, 2011, Journal of cellular biochemistry.

Systemic cell therapy for muscular dystrophies

H. van Bokhoven, D. G. Wansink, B. van Engelen, 2020, Stem Cell Reviews and Reports.

Abnormalities in Skeletal Muscle Myogenesis, Growth, and Regeneration in Myotonic Dystrophy

B. Wieringa, D. G. Wansink, L. M. André, 2018, Front. Neurol..

CHAPTER 5 – Normal and Pathophysiological Significance of Myotonic Dystrophy Protein Kinase

B. Wieringa, D. G. Wansink, R. Herpen, 2006 .

Recovery in the Myogenic Program of Congenital Myotonic Dystrophy Myoblasts after Excision of the Expanded (CTG)n Repeat

M. Willemse, B. Wieringa, D. G. Wansink, 2019, International journal of molecular sciences.

A comprehensive atlas of fetal splicing patterns in the brain of adult myotonic dystrophy type 1 patients

Eric T. Wang, E. Wang, D. G. Wansink, 2021, bioRxiv.

CRISPR/Cas Applications in Myotonic Dystrophy: Expanding Opportunities

D. G. Wansink, Lise Ripken, C. R. M. Ausems, 2019, International journal of molecular sciences.

Intrinsic Myogenic Potential of Skeletal Muscle-Derived Pericytes from Patients with Myotonic Dystrophy Type 1

M. Willemse, H. van Bokhoven, D. G. Wansink, 2019, Molecular therapy. Methods & clinical development.

A low absolute number of expanded transcripts is involved in myotonic dystrophy type 1 manifestation in muscle

B. Wieringa, A. González-Barriga, D. G. Wansink, 2016, Human molecular genetics.

Divergent Mitochondrial and Endoplasmic Reticulum Association of DMPK Splice Isoforms Depends on Unique Sequence Arrangements in Tail Anchors

Ralph J A Oude Ophuis, J. Fransen, B. Wieringa, 2005, Molecular and Cellular Biology.

Molecular therapy in myotonic dystrophy: focus on RNA gain-of-function.

B. Wieringa, S. Mulders, D. G. Wansink, 2010, Human molecular genetics.

Transcription by RNA Polymerase II and Nuclear Architecture

L. Jong, D. G. Wansink, R. Driel, 1997 .

RNA polymerase II transcription is concentrated outside replication domains throughout S-phase.

J A Aten, J. Aten, R. van Driel, 1994, Journal of cell science.

E. Cuppen, B. Wieringa, D. G. Wansink, 2000, European journal of cell biology.

Transgenic mouse models for myotonic dystrophy type 1 (DM1)

B. Wieringa, D. G. Wansink, 2003, Cytogenetic and Genome Research.

A Tail-Anchored Myotonic Dystrophy Protein Kinase Isoform Induces Perinuclear Clustering of Mitochondria, Autophagy, and Apoptosis

Ralph J A Oude Ophuis, J. Fransen, B. Wieringa, 2009, PloS one.

Gene duplication and conversion events shaped three homologous, differentially expressed myosin regulatory light chain (MLC2) genes.

B. Wieringa, D. G. Wansink, Gijs J. Overheul, 2012, European journal of cell biology.

Alternative Splicing Controls Myotonic Dystrophy Protein Kinase Structure, Enzymatic Activity, and Subcellular Localization

B. Wieringa, B. Hemmings, D. G. Wansink, 2003, Molecular and Cellular Biology.

Coiled–coil interactions modulate multimerization, mitochondrial binding and kinase activity of myotonic dystrophy protein kinase splice isoforms

B. Wieringa, S. Mulders, D. G. Wansink, 2006, The FEBS journal.

Assisted delivery of antisense therapeutics in animal models of heritable neurodegenerative and neuromuscular disorders: a systematic review and meta-analysis

R. Brock, D. G. Wansink, J. van Luijk, 2018, Scientific Reports.

Block or degrade? Balancing on- and off-target effects of antisense strategies against transcripts with expanded triplet repeats in DM1

M. Willemse, D. G. Wansink, P. A. ’. 'T Hoen, 2023, Molecular therapy. Nucleic acids.

Fen1 does not control somatic hypermutability of the (CTG) n · (CAG) n repeat in a knock‐in mouse model for DM1

M. Nelen, B. Wieringa, D. G. Wansink, 2006, FEBS letters.

Certainty-based marking in a formative assessment improves student course appreciation but not summative examination scores

A. Cambi, H. Pluk, P. Klaren, 2019, BMC Medical Education.

UvA-DARE ( Digital Academic Repository ) RNA polymerase II transcription is concentrated outside replication domains throughout S-phase

L. Jong, D. G. Wansink, R. Driel, 1994 .

Advanced Fluorescence Imaging to Distinguish Between Intracellular Fractions of Antisense Oligonucleotides.

R. Brock, D. G. Wansink, M. L. van der Bent, 2020, Methods in molecular biology.

Nations Move to Ban POPs

D. G. Wansink, W. J. van den Broek, B. Wieringa, 1997, Environmental Health Perspectives.

CAG repeat instability in a mouse model for myotonic dystrophy type 1 is associated with changes in cell nuclearity and DNA ploidy

B. Wieringa, D. G. Wansink, W. V. D. Broek, 2007 .

Imaging of CPP Delivery Mechanisms of Oligonucleotides.

R. Brock, D. G. Wansink, A. H. van Asbeck, 2021, Methods in molecular biology.

Fluorescent labeling of nascent RNA reveals transcription by RNA polymerase II in domains scattered throughout the nucleus

B. Steensel, W. Schul, D. G. Wansink, 1993, The Journal of cell biology.

Differentiation shifts from a reversible to an irreversible heterochromatin state at the DM1 locus

Y. Buganim, Y. Drier, R. Eiges, 2024, Nature communications.